Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCB9 ABCA7 TAP2 ABCC6	6.41e-05	49	88	4	GO:0140359
GeneOntologyMolecularFunction	ABC-type peptide transporter activity	ABCB9 TAP2	1.15e-04	4	88	2	GO:0015440
GeneOntologyMolecularFunction	carnitine O-palmitoyltransferase activity	CPT1A CPT1B	1.15e-04	4	88	2	GO:0004095
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ATP2C1 ABCB9 ABCA7 TAP2 ABCC6	1.21e-04	109	88	5	GO:0042626
GeneOntologyMolecularFunction	O-palmitoyltransferase activity	CPT1A CPT1B	1.90e-04	5	88	2	GO:0016416
GeneOntologyMolecularFunction	carnitine O-acyltransferase activity	CPT1A CPT1B	2.85e-04	6	88	2	GO:0016406
GeneOntologyMolecularFunction	alkaline phosphatase activity	ALPI ALPG	2.85e-04	6	88	2	GO:0004035
GeneOntologyMolecularFunction	kainate selective glutamate receptor activity	GRIK3 GRIK5	2.85e-04	6	88	2	GO:0015277
GeneOntologyMolecularFunction	ATP-dependent activity	MYH7 ATP2C1 ABCB9 CLPB KIFC3 ARID1A ABCA7 TAP2 ABCC6 ACSL5	3.67e-04	614	88	10	GO:0140657
GeneOntologyMolecularFunction	peptide transmembrane transporter activity	ABCB9 TAP2	6.78e-04	9	88	2	GO:1904680
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ATP2C1 ABCB9 ABCA7 TAP2 ABCC6	1.15e-03	178	88	5	GO:0015399
Domain	ABC_transporter_CS	ABCB9 ABCA7 TAP2 ABCC6	4.49e-05	42	88	4	IPR017871
Domain	CPT_N	CPT1A CPT1B	6.56e-05	3	88	2	IPR032476
Domain	CPT_N	CPT1A CPT1B	6.56e-05	3	88	2	PF16484
Domain	ABC_tran	ABCB9 ABCA7 TAP2 ABCC6	7.64e-05	48	88	4	PF00005
Domain	ABC_TRANSPORTER_2	ABCB9 ABCA7 TAP2 ABCC6	7.64e-05	48	88	4	PS50893
Domain	ABC_TRANSPORTER_1	ABCB9 ABCA7 TAP2 ABCC6	8.29e-05	49	88	4	PS00211
Domain	ABC_transporter-like	ABCB9 ABCA7 TAP2 ABCC6	8.98e-05	50	88	4	IPR003439
Domain	Alk_phosphatase	ALPI ALPG	1.31e-04	4	88	2	PF00245
Domain	Alkaline_phosphatase_AS	ALPI ALPG	1.31e-04	4	88	2	IPR018299
Domain	Alkaline_phosphatase	ALPI ALPG	1.31e-04	4	88	2	IPR001952
Domain	alkPPc	ALPI ALPG	1.31e-04	4	88	2	SM00098
Domain	ALKALINE_PHOSPHATASE	ALPI ALPG	1.31e-04	4	88	2	PS00123
Domain	ABC_membrane	ABCB9 TAP2 ABCC6	1.90e-04	24	88	3	PF00664
Domain	ARM-type_fold	FOCAD CAND2 MROH6 HEATR5A HUWE1 LRBA ARID1A SPAG6	1.97e-04	339	88	8	IPR016024
Domain	ARM-like	CAND2 MROH6 HEATR5A HUWE1 LRBA ARID1A SPAG6	2.86e-04	270	88	7	IPR011989
Domain	ABC_TM1F	ABCB9 TAP2 ABCC6	3.04e-04	28	88	3	PS50929
Domain	ABC1_TM_dom	ABCB9 TAP2 ABCC6	3.04e-04	28	88	3	IPR011527
Domain	Carn_acyltransf	CPT1A CPT1B	4.54e-04	7	88	2	PF00755
Domain	ACYLTRANSF_C_1	CPT1A CPT1B	4.54e-04	7	88	2	PS00439
Domain	Carn_acyl_trans	CPT1A CPT1B	4.54e-04	7	88	2	IPR000542
Domain	ACYLTRANSF_C_2	CPT1A CPT1B	4.54e-04	7	88	2	PS00440
Domain	AAA+_ATPase	ABCB9 CLPB ABCA7 TAP2 ABCC6	5.96e-04	144	88	5	IPR003593
Domain	AAA	ABCB9 CLPB ABCA7 TAP2 ABCC6	5.96e-04	144	88	5	SM00382
Domain	-	CAND2 MROH6 HEATR5A LRBA ARID1A SPAG6	6.35e-04	222	88	6	1.25.10.10
Domain	Iontro_rcpt	GRIK3 GRIK5	3.20e-03	18	88	2	IPR001320
Domain	Lig_chan-Glu_bd	GRIK3 GRIK5	3.20e-03	18	88	2	PF10613
Domain	Iono_rcpt_met	GRIK3 GRIK5	3.20e-03	18	88	2	IPR001508
Domain	Glu/Gly-bd	GRIK3 GRIK5	3.20e-03	18	88	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIK3 GRIK5	3.20e-03	18	88	2	SM00918
Domain	Lig_chan	GRIK3 GRIK5	3.20e-03	18	88	2	PF00060
Domain	PBPe	GRIK3 GRIK5	3.20e-03	18	88	2	SM00079
Domain	Alkaline_phosphatase_core	ALPI ALPG	9.34e-03	31	88	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ALPI ALPG	9.34e-03	31	88	2	IPR017849
Domain	-	ALPI ALPG	9.34e-03	31	88	2	3.40.720.10
Pathway	KEGG_MEDICUS_REFERENCE_BETA_OXIDATION_ACYL_COA_SYNTHESIS	CPT1A CPT1B ACSL5	1.07e-05	11	58	3	M47626
Pathway	KEGG_ABC_TRANSPORTERS	ABCB9 ABCA7 TAP2 ABCC6	3.10e-05	44	58	4	M11911
Pathway	REACTOME_DIGESTION	SI ALPI ALPG	8.34e-05	21	58	3	MM15526
Pathway	REACTOME_DIGESTION_AND_ABSORPTION	SI ALPI ALPG	1.43e-04	25	58	3	MM15557
Pathway	WP_FATTY_ACID_BETAOXIDATION	CPT1A CPT1B ACSL5	3.61e-04	34	58	3	M39596
Pathway	WP_FATTY_ACID_BETAOXIDATION	CPT1A CPT1B ACSL5	3.61e-04	34	58	3	MM15937
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FOCAD TNRC18 MROH6 POLE ZNF335 SIPA1L3 SBF2 ULK1 KIFC3 HUWE1 LRBA ARID1A ABCA7 BAP1 CD276 FANCA	1.94e-08	1105	89	16	35748872
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HMBOX1 TNRC18 ATP2C1 PXDN MYT1 SIPA1L3 SBF2 SPACA6 HUWE1 LRBA CPT1A ARID1A MDM4 HNRNPL ITPK1	5.37e-06	1489	89	15	28611215
Pubmed	Variants within the muscle and liver isoforms of the carnitine palmitoyltransferase I (CPT1) gene interact with fat intake to modulate indices of obesity in French-Canadians.	CPT1A CPT1B	6.48e-06	2	89	2	17089095
Pubmed	Crystal structures of the glutamate receptor ion channel GluK3 and GluK5 amino-terminal domains.	GRIK3 GRIK5	6.48e-06	2	89	2	20951142
Pubmed	Identification and characterization of a TAP-family gene in the lamprey.	ABCB9 TAP2	6.48e-06	2	89	2	12679854
Pubmed	Evidence for a founder effect for pseudoxanthoma elasticum in the Afrikaner population of South Africa.	ABCC6 FANCA	6.48e-06	2	89	2	12384774
Pubmed	Expression and regulation of carnitine palmitoyltransferase-Ialpha and -Ibeta genes.	CPT1A CPT1B	6.48e-06	2	89	2	10408760
Pubmed	Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B).	CPT1A CPT1B	6.48e-06	2	89	2	9070950
Pubmed	Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis.	CPT1A CPT1B	6.48e-06	2	89	2	9013572
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	ATP2C1 RARS1 SPRING1 COX6C TMPO HUWE1 CPT1A ARID1A	7.73e-06	392	89	8	33144569
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	GDPD1 ATP2C1 RARS1 MGST3 AMOT PKM TMPO CDC20 TAP2 ABHD16A ACSL5 HNRNPL CD276	1.17e-05	1203	89	13	29180619
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	FOCAD RARS1 AMOT PKM TMPO GRIK5 HUWE1 CPT1B HNRNPL FANCA	1.91e-05	736	89	10	29676528
Pubmed	Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases.	ALPI ALPG	1.94e-05	3	89	2	3443302
Pubmed	Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues.	CPT1A CPT1B	1.94e-05	3	89	2	11023836
Pubmed	Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene.	CPT1A CPT1B	1.94e-05	3	89	2	8307575
Pubmed	Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.	ALPI ALPG	1.94e-05	3	89	2	19407215
Pubmed	Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes.	ALPI ALPG	1.94e-05	3	89	2	2286375
Pubmed	Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia.	GRIK3 GRIK5	1.94e-05	3	89	2	16325263
Pubmed	A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2.	ABCB9 TAP2	1.94e-05	3	89	2	11011155
Pubmed	Intestinal Alkaline Phosphatase Regulates Tight Junction Protein Levels.	ALPI ALPG	1.94e-05	3	89	2	27106638
Pubmed	Organic pyrophosphates as substrates for human alkaline phosphatases.	ALPI ALPG	1.94e-05	3	89	2	16742561
Pubmed	Detection of TAP family dimerizations by an in vivo assay in mammalian cells.	ABCB9 TAP2	1.94e-05	3	89	2	15518576
Pubmed	Effects of disruption of the embryonic alkaline phosphatase gene on preimplantation development of the mouse.	ALPI ALPG	1.94e-05	3	89	2	10767088
Pubmed	MUSEAP, a novel reporter gene for the study of long-term gene expression in immunocompetent mice.	ALPI ALPG	1.94e-05	3	89	2	11722850
Pubmed	Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels.	HMBOX1 SOCS1	1.94e-05	3	89	2	33388421
Pubmed	Hydrophobicity as a driver of MHC class I antigen processing.	ABCB9 TAP2	1.94e-05	3	89	2	21378750
Pubmed	A novel phosphatase upregulated in Akp3 knockout mice.	ALPI ALPG	1.94e-05	3	89	2	17901166
Pubmed	Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas.	ARID1A BAP1	1.94e-05	3	89	2	24185509
Pubmed	A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.	MYH7 PEG3 PKM CPT1B	2.56e-05	66	89	4	32212902
Pubmed	Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice.	SI ALPI ALPG	2.76e-05	23	89	3	24680895
Pubmed	Interactions between CD36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet.	ALPI ALPG	3.87e-05	4	89	2	21900644
Pubmed	Novel Role of the ALPI Gene Associated with Constipation Caused by Complement Component 3 Deficiency.	ALPI ALPG	3.87e-05	4	89	2	39273477
Pubmed	Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity.	CPT1A CPT1B	3.87e-05	4	89	2	11095714
Pubmed	Distribution of kainate receptor subunits at hippocampal mossy fiber synapses.	GRIK3 GRIK5	3.87e-05	4	89	2	12954862
Pubmed	The role of fatty acid β-oxidation in lymphangiogenesis.	FLT4 CPT1A	3.87e-05	4	89	2	28024299
Pubmed	Increased expression of carnitine palmitoyltransferase I gene is repressed by administering L-carnitine in the hearts of carnitine-deficient juvenile visceral steatosis mice.	CPT1A CPT1B	3.87e-05	4	89	2	8830050
Pubmed	Structural evidence of functional divergence in human alkaline phosphatases.	ALPI ALPG	3.87e-05	4	89	2	12372831
Pubmed	The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions.	CPT1A CPT1B	3.87e-05	4	89	2	26041663
Pubmed	Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool.	GRIK3 GRIK5	3.87e-05	4	89	2	15513934
Pubmed	Stage-specific expression patterns of alkaline phosphatase during development of the first arch skeleton in inbred C57BL/6 mouse embryos.	ALPI ALPG	3.87e-05	4	89	2	9061447
Pubmed	Haplotype analysis of carnitine transporters and left ventricular mass in human essential hypertension.	CPT1A CPT1B	3.87e-05	4	89	2	15647998
Pubmed	Dual LQT1 and HCM phenotypes associated with tetrad heterozygous mutations in KCNQ1, MYH7, MYLK2, and TMEM70 genes in a three-generation Chinese family.	MYH7 TMEM70	3.87e-05	4	89	2	25825456
Pubmed	Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses.	GRIK3 GRIK5	3.87e-05	4	89	2	19369569
Pubmed	Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.	ALPI ALPG	3.87e-05	4	89	2	9056646
Pubmed	Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction.	CPT1A CPT1B	3.87e-05	4	89	2	26253087
Pubmed	Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism.	PKM CPT1A CPT1B	4.53e-05	27	89	3	24086110
Pubmed	Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming.	MYH7 CPT1A CPT1B	5.07e-05	28	89	3	28159809
Pubmed	Developmental expression patterns of kainate receptors in the mouse spinal cord.	GRIK3 GRIK5	6.44e-05	5	89	2	23076118
Pubmed	Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.	GRIK3 GRIK5	6.44e-05	5	89	2	28228252
Pubmed	Development of laminar distributions of kainate receptors in the somatosensory cortex of mice.	GRIK3 GRIK5	6.44e-05	5	89	2	9593973
Pubmed	Determination of kainate receptor subunit ratios in mouse brain using novel chimeric protein standards.	GRIK3 GRIK5	6.44e-05	5	89	2	26448475
Pubmed	Kainate receptors: pharmacology, function and therapeutic potential.	GRIK3 GRIK5	6.44e-05	5	89	2	18793656
Pubmed	Central role of pyrophosphate in acellular cementum formation.	ALPI ALPG	6.44e-05	5	89	2	22675556
Pubmed	Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn.	GRIK3 GRIK5	6.44e-05	5	89	2	12223554
Pubmed	Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.	GRIK3 GRIK5	6.44e-05	5	89	2	9466455
Pubmed	Two alkaline phosphatase genes are expressed during early development in the mouse embryo.	ALPI ALPG	6.44e-05	5	89	2	2133555
Pubmed	Molecular determinants of kainate receptor trafficking.	GRIK3 GRIK5	6.44e-05	5	89	2	18358623
Pubmed	Germ cell nuclear antigen (GCNA1) expression does not require a gonadal environment or steroidogenic factor 1: examination of GCNA1 in ectopic germ cells and in Ftz-F1 null mice.	ALPI ALPG	6.44e-05	5	89	2	9291464
Pubmed	Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains.	GRIK3 GRIK5	6.44e-05	5	89	2	29058671
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	RARS1 TTC28 AMOT PKM TMPO HUWE1 LRBA ARID1A	8.44e-05	549	89	8	38280479
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FOCAD PXDN TTC28 PEG3 HEATR5A ULK1 RUBCN	8.62e-05	407	89	7	12693553
Pubmed	DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.	RARS1 PKM TMPO HUWE1 HNRNPL	8.98e-05	175	89	5	25756610
Pubmed	Hydrolysis and absorption of pantothenate and its coenzymes in the rat small intestine.	ALPI ALPG	9.65e-05	6	89	2	6619987
Pubmed	Dissection of the odontoblast differentiation process in vitro by a combination of FGF1, FGF2, and TGFbeta1.	ALPI ALPG	9.65e-05	6	89	2	10878613
Pubmed	Genomics of the human carnitine acyltransferase genes.	CPT1A CPT1B	9.65e-05	6	89	2	11001805
Pubmed	N-glycan content modulates kainate receptor functional properties.	GRIK3 GRIK5	9.65e-05	6	89	2	28714086
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	ATP2C1 PRR5L RARS1 ABCB9 CLPB KIFC3 MDM4 TAP2 RUBCN HNRNPL	1.29e-04	925	89	10	28986522
Pubmed	NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter.	PKM ULK1	1.35e-04	7	89	2	31959741
Pubmed	Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.	GRIK3 GRIK5	1.35e-04	7	89	2	17428973
Pubmed	Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters.	ALPI ALPG	1.35e-04	7	89	2	26831517
Pubmed	Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.	GRIK3 GRIK5	1.35e-04	7	89	2	19342380
Pubmed	The interplay of UBE2T and Mule in regulating Wnt/β-catenin activation to promote hepatocellular carcinoma progression.	HUWE1 FANCA	1.35e-04	7	89	2	33542213
Pubmed	HIV-1 Vpr enhances PPARβ/δ-mediated transcription, increases PDK4 expression, and reduces PDC activity.	CPT1A CPT1B	1.35e-04	7	89	2	23842279
Pubmed	Emilin1 deficiency causes structural and functional defects of lymphatic vasculature.	FLT4 MMRN2	1.35e-04	7	89	2	18411305
Pubmed	Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate.	GRIK3 GRIK5	1.35e-04	7	89	2	1310861
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	ABCB9 MGST3 ABCA7 TAP2 ABCC6	1.42e-04	193	89	5	19343046
Pubmed	Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia.	GRIK3 GRIK5	1.79e-04	8	89	2	19125103
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	PXDN RARS1 AMOT PKM TMPO HUWE1 CPT1A HNRNPL	1.80e-04	613	89	8	22268729
Pubmed	Defining the membrane proteome of NK cells.	GDPD1 ATP2C1 RARS1 MGST3 TMPO HUWE1 LRBA CPT1A TAP2 ACSL5 HNRNPL	1.95e-04	1168	89	11	19946888
Pubmed	Molecular enzymology of carnitine transfer and transport.	CPT1A CPT1B	2.30e-04	9	89	2	11257506
Pubmed	Expression of glutamate receptor subunit genes during development of the mouse retina.	GRIK3 GRIK5	2.30e-04	9	89	2	9051806
Pubmed	A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation.	ALPI ALPG	2.30e-04	9	89	2	21324897
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	FOCAD RARS1 AMOT PKM TMPO HUWE1	2.61e-04	344	89	6	36282215
Pubmed	NEDD4L-mediated Merlin ubiquitination facilitates Hippo pathway activation.	AMOT HUWE1	2.88e-04	10	89	2	33058421
Pubmed	STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I.	ULK1 RUBCN	2.88e-04	10	89	2	31696776
Pubmed	Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance.	MYH7 RTL1	2.88e-04	10	89	2	26487685
Pubmed	Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis.	ALPI ALPG	2.88e-04	10	89	2	37709732
Pubmed	LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease.	ULK1 RUBCN	2.88e-04	10	89	2	31257024
Pubmed	Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity.	SIPA1L3 TMPO TAP2	3.27e-04	52	89	3	23182705
Pubmed	IFN-λ derived from nonsusceptible enterocytes acts on tuft cells to limit persistent norovirus.	ALPI ALPG	3.51e-04	11	89	2	37703370
Pubmed	Genomic imprinting in Dicer1-hypomorphic mice.	RTL1 PEG3	3.51e-04	11	89	2	16575173
Pubmed	A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis.	ALPI ALPG	4.20e-04	12	89	2	27802136
Pubmed	TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors.	ALPI ALPG	4.20e-04	12	89	2	31289197
Pubmed	Temperature dependence of the control of energy homeostasis requires CART signaling.	CPT1A CPT1B	4.20e-04	12	89	2	27080622
Pubmed	Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.	AMOT HUWE1 ARID1A	4.29e-04	57	89	3	38223760
Pubmed	Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies.	KIAA1210 CAND2 RARS1 COX6C HUWE1	4.60e-04	249	89	5	30097533
Pubmed	Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex.	ARID1A FANCA	4.96e-04	13	89	2	11726552
Pubmed	IRGM governs the core autophagy machinery to conduct antimicrobial defense.	ULK1 RUBCN	4.96e-04	13	89	2	25891078
Pubmed	General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions.	ALPI ALPG	5.78e-04	14	89	2	36639541
Pubmed	Maternal diabetes causes coordinated down-regulation of genes involved with lipid metabolism in the murine fetal heart.	CPT1A CPT1B	5.78e-04	14	89	2	18502258
Interaction	RAD51D interactions	ATP2C1 SPRING1 KIFC3 HUWE1 TAP2 FANCA	6.00e-06	102	89	6	int:RAD51D
Interaction	GRIK1 interactions	SIPA1L3 GRIK3 GRIK5 HNRNPL	1.88e-05	36	89	4	int:GRIK1
Interaction	LHPP interactions	MYH7 PKM HMX2 HNRNPL	2.10e-05	37	89	4	int:LHPP
Cytoband	12q24.3	POLE ULK1	5.55e-05	6	89	2	12q24.3
GeneFamily	Alkaline phosphatases	ALPI ALPG	6.26e-05	4	59	2	1072
GeneFamily	Glutamate ionotropic receptor kainate type subunits	GRIK3 GRIK5	1.04e-04	5	59	2	1199
GeneFamily	ATP binding cassette subfamily B	ABCB9 TAP2	5.65e-04	11	59	2	806
ToppCell	facs-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGST3 COX6C PKM BAIAP2L2 ALPI	2.34e-05	172	88	5	87a30a219b0a6979abb5fba292a2d8ea946fd849
ToppCell	facs-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGST3 COX6C PKM BAIAP2L2 ALPI	2.34e-05	172	88	5	5030ac31709cac236bb58f4ef9d545d24690411a
ToppCell	droplet-Kidney-nan-3m-Hematologic-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMBOX1 CAND2 SOCS1 HUWE1 AQP9	2.98e-05	181	88	5	58d7e76dfaa818aeaef7f129c4472bf5b6563218
ToppCell	droplet-Kidney-nan-3m-Hematologic\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMBOX1 CAND2 SOCS1 HUWE1 AQP9	2.98e-05	181	88	5	5d76e99bf2b5b337041efd3cd33bebbb0637b64e
ToppCell	droplet-Kidney-nan-3m-Hematologic-leukocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMBOX1 CAND2 SOCS1 HUWE1 AQP9	2.98e-05	181	88	5	970fc90e27236ee30190f1a02f418a378919c60b
ToppCell	CV-Healthy-7\|CV / Virus stimulation, Condition and Cluster	GDPD1 ULK1 ABHD16A JHY FANCA	3.22e-05	184	88	5	0e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 MMRN2 SLC25A53 GRIK5 EBF4	3.40e-05	186	88	5	2cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	TNRC18 TTC28 SIPA1L3 ARID1A ABCC6	3.40e-05	186	88	5	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 MMRN2 SLC25A53 GRIK5 EBF4	3.40e-05	186	88	5	90d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	TNRC18 TTC28 SIPA1L3 ARID1A ABCC6	3.40e-05	186	88	5	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	HGD ADAMTS6 SBF2 LRBA ABCC6	3.48e-05	187	88	5	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TNRC18 ABCB9 SBF2 CDC20	3.80e-05	95	88	4	3d6b97576ce4e7a3e495cbc7246ea8c0b2a386f7
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGST3 PKM LRBA CPT1A BAIAP2L2	3.85e-05	191	88	5	297bc79adc5fef211497819b4861b52cd26ac754
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGST3 PKM LRBA CPT1A BAIAP2L2	3.85e-05	191	88	5	e1ec165ba6578cefd88895e7e183190e79f733a4
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 PEG3 COX6C PKM HUWE1	4.15e-05	194	88	5	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	5'-Adult-SmallIntestine-Epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MGST3 SI BAIAP2L2 ACSL5 ALPI	4.57e-05	198	88	5	8d629492d2199de8e036c19e9dacceb9c9e721a0
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYT1 TMPO GRIK3 HMX2 CDC20	4.57e-05	198	88	5	2ee8ac82ef1b8ebabc8dd824211bbb471f2af8ac
ToppCell	5'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MGST3 SI BAIAP2L2 ACSL5 ALPI	4.57e-05	198	88	5	6e6af8fad09f8e48b3f2ce463d5773b6a69864d1
ToppCell	5'-Adult-SmallIntestine\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MGST3 SI BAIAP2L2 ACSL5 ALPI	4.68e-05	199	88	5	a5fffe381be1ba7d192b68d1d3937ce47663658e
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	FOCAD TTC28 SIPA1L3 SBF2 LRBA	4.68e-05	199	88	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	5'-Adult-SmallIntestine-Epithelial-mature_enterocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MGST3 SI BAIAP2L2 ACSL5 ALPI	4.68e-05	199	88	5	01c2721bc82cd672e9477029b4a7ecc77e2f1b00
Disease	Intrahepatic Cholangiocarcinoma	PEG3 ARID1A BAP1	4.16e-05	24	83	3	C0345905
Disease	Extrahepatic Cholangiocarcinoma	PEG3 ARID1A BAP1	4.16e-05	24	83	3	C3805278
Disease	Cholangiocarcinoma	PEG3 ARID1A BAP1	5.32e-05	26	83	3	C0206698
Disease	leukemia	AQP9 BAP1 FANCA	5.07e-04	55	83	3	C0023418
Disease	Bladder Neoplasm	ARID1A MDM4 BAP1 FANCA	6.67e-04	140	83	4	C0005695
Disease	Malignant neoplasm of urinary bladder	ARID1A MDM4 BAP1 FANCA	6.85e-04	141	83	4	C0005684
Disease	thyroxine measurement, triiodothyronine measurement	RARS1 ABCB9	1.03e-03	17	83	2	EFO_0005130, EFO_0008392
Disease	alcoholic hepatitis (biomarker_via_orthology)	SOCS1 CPT1A	1.16e-03	18	83	2	DOID:12351 (biomarker_via_orthology)
Disease	intrahepatic cholangiocarcinoma (is_marker_for)	ARID1A BAP1	1.30e-03	19	83	2	DOID:4928 (is_marker_for)
Disease	Sarcoma	FLT4 MDM4	1.59e-03	21	83	2	C1261473
Disease	Nasopharyngeal carcinoma	ARID1A BAP1	1.74e-03	22	83	2	C2931822

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSLANAFADQVVATM	AQP9	156	O43315
MRHFALDAAATVAAQ	AMOT	691	Q4VCS5
MAQFAFESDLHSLLQ	CDC20	1	Q12834
FIAENETAVMHLQSA	CSRNP2	316	Q9H175
NEANAMDVVVQFAIH	ABHD16A	326	O95870
MAEAHQAVAFQFTVT	CPT1A	1	P50416
VIDDDIVNNMFFAHQ	BAP1	71	Q92560
SQMANEQGLFDVHSV	CD276	411	Q5ZPR3
NHLNTIANMAAAAQI	DACH2	341	Q96NX9
AVAAQMQHVAAFSLV	CELF6	271	Q96J87
AVISVLMHQFDDAVS	ATP2C1	91	P98194
EAAKLMAAHITANTN	ADAMTS6	426	Q9UKP5
HSMVAFVNRASNAIL	ABCA7	1481	Q8IZY2
AEQNAHMEAVLQRSA	RBFA	146	Q8N0V3
VHFFNREDAVAAMSV	RBM46	276	Q8TBY0
EIQLSHANRMAAEAQ	MYH7	1626	P12883
FNSLVAAMVIDHFSI	PCDHA6	281	Q9UN73
ETAVAMHVAANSIQN	ARID1A	896	O14497
SHEMAIVFNQEGLNA	ITPK1	166	Q13572
IMHASNNDVQASRAL	JHY	416	Q6NUN7
QIATHTAFVAKAMQA	TMPO	581	P42166
AAVLNNVAHTFGLMD	GMEB1	301	Q9Y692
AAQTLALAQDHSMDI	MDM4	116	O15151
STVFSQAIHFANLMV	SBF2	741	Q86WG5
LTAAVMEANQTGHEF	MMRN2	206	Q9H8L6
ESVNRLHAQMQAFVS	BAIAP2L2	156	Q6UXY1
LHAQMQAFVSESQRA	BAIAP2L2	161	Q6UXY1
AVEMAAVNHTILALA	HMBOX1	391	Q6NT76
AVMILQSEGHNIFAN	PDE11A	741	Q9HCR9
ELEAANMAHASAQTL	HMX2	211	A2RU54
VMDFVNSSDNVIFVH	LRBA	1341	P50851
AFIQTQQLHAAMADT	PKM	11	P14618
ENLENTMAAFQHAVK	GDPD1	51	Q8N9F7
AVAAAAHVSAQQVAM	MROH6	656	A6NGR9
FVEARAAVHGLSMQQ	POLE	371	Q07864
AASFIMVAHLAINVS	MGST3	16	O14880
VDLITNLDMAAFQSH	HUWE1	436	Q7Z6Z7
VMAESTIQSFDAINH	PEG3	801	Q9GZU2
RFVVAAGENMHQVAD	METTL7A	121	Q9H8H3
TVANAHSDIQLLAMA	PRR5L	291	Q6MZQ0
VQEQSFVAHVMAFAA	ALPI	471	P09923
VQEQTFIAHVMAFAA	ALPG	471	P10696
AHESAAMAASANIEN	TMEM123	26	Q8N131
NANSAHFDIALAQEM	HEATR5A	1236	Q86XA9
HIQDEVDFLFSMAAN	GLT6D1	161	Q7Z4J2
VLAVSDNMFVHNNSK	EBF4	226	Q9BQW3
QHADVARAMLSDFVQ	FANCA	226	O15360
NHMAVAFVLSLGVAA	COX6C	21	P09669
AMITHQNIVSNAAAF	ACSL5	271	Q9ULC5
AMAAVAGVALHSFVQ	ERVK-21	481	P61565
ALDMIFSAAQHSNAA	FGD2	276	Q7Z6J4
AVDRAITHLNNNFMF	HNRNPL	431	P14866
SVAAEAQVFMNPSHI	KIAA1210	686	Q9ULL0
FIMTSNVASDEIAQH	CLPB	491	Q9H078
RMLAAVGAAVQHVDN	HBM	61	Q6B0K9
QVMNAEEHAFRFSAN	GRIK3	51	Q13003
ALSAALMFDAVHVVV	GRIK5	301	Q16478
ALVNESDMHVAQLAV	CAND2	701	O75155
SDMHVAQLAVDFLAT	CAND2	706	O75155
AAFLLSDAHVTAMLQ	RUBCN	156	Q92622
DTFTQMTHALQELAA	SPACA6	81	W5XKT8
MAEAHQAVAFQFTVT	CPT1B	1	Q92523
QHGADMLAAISQVLN	FOCAD	601	Q5VW36
NFMVINSVAFDHADP	HGD	281	Q93099
IDQILNSFLAHFSMA	RTL1	1056	A6NKG5
GQSVHFQTIFAAAQM	RARS1	411	P54136
AAVAFQNLFMAVEDH	SPRING1	151	Q9H741
VDAGAVAHLAQMILN	SPAG6	206	O75602
FAVHTLVAENAMNAE	ABCC6	551	O95255
VYALVSAHLANIVMN	RHBDL3	281	P58872
FQKAQAISAFHEMIQ	IFNA16	71	P05015
AFARAQVEMKAVHEN	KIFC3	346	Q9BVG8
FHAVVAALEQMASEA	PIK3R6	226	Q5UE93
AHFDVQSMLFDLNEA	SIPA1L3	341	O60292
VMAAAQAAHADDFIQ	TAP2	576	Q03519
NAHGVFLLNSNAMDV	SI	1161	P14410
VVFRQQIHAMAVSEA	SLC25A53	51	Q5H9E4
MVAHNQVAADNAVST	SOCS1	1	O15524
MVVEAAQKANAHGFI	ABCB9	611	Q9NP78
GNFAATQMAVLAAQH	TNRC18	516	O15417
KERAAAAAAAAQMHA	SOGA3	266	Q5TF21
DVVFNAAHMLRQASL	TMTC2	746	Q8N394
QVSTMALHIAQADAE	FLT4	1201	P35916
MAHTVALDLAAINIQ	PXDN	1146	Q92626
TFVIEAMAAANAQLH	TMEM104	61	Q8NE00
LIFAFANAVGVAMHT	SLC12A3	221	P55017
EQHLSIAAQMNDLAA	TTC28	1061	Q96AY4
AMLAETSTVFHQNDV	TMEM70	186	Q9BUB7
HSAVTAVADAAMAQA	ZNF335	1296	Q9H4Z2
FSHAVQMVQSAALDE	ULK1	981	O75385
HVAAVAQMDFISKNF	TYW5	61	A2RUC4
MAAESDVLHFQFEQQ	ZBTB6	1	Q15916
QDAEAAHMAATAILN	MYT1	621	Q01538