Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR52N1 OR10Z1

5.80e-094318814GO:0004984
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR1 ITPR2 ITPR3

8.27e-083883GO:0005220
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR52R1 OR2AK2 CALCR OR2B2 OR2T27 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 ADGRF1 GPR162 OR56B4 OR13J1 OR52N1 OR10Z1

2.63e-078848817GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR52R1 OR2AK2 CALCR OR2B2 OR2T27 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 ADGRF1 GPR162 OR56B4 OR13J1 OR52N1 OR10Z1 TMEM63A

2.07e-0513538818GO:0004888
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

ITPR1 ITPR2 ITPR3

2.91e-0514883GO:0070679
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

ITPR1 ITPR2 ITPR3

6.43e-0518883GO:0015278
GeneOntologyMolecularFunctionligand-gated calcium channel activity

ITPR1 ITPR2 ITPR3

3.40e-0431883GO:0099604
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

ITPR1 ITPR2 ITPR3

4.10e-0433883GO:0005217
GeneOntologyMolecularFunctionsmall GTPase binding

TNPO1 TNPO2 FARP1 LRRK2 FGD1 RIC1 FGD3

5.42e-04321887GO:0031267
GeneOntologyMolecularFunctionGTPase binding

TNPO1 TNPO2 FARP1 LRRK2 FGD1 RIC1 FGD3

1.06e-03360887GO:0051020
GeneOntologyMolecularFunctionalcohol binding

SOAT1 ITPR1 ITPR2 ITPR3

1.08e-03102884GO:0043178
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR52N1 OR10Z1

3.98e-094328814GO:0050911
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR52N1 OR10Z1 ITPR3

9.96e-095478815GO:0007606
GeneOntologyBiologicalProcesssensory perception of smell

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR52N1 OR10Z1

1.01e-084658814GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR52N1 OR10Z1

1.72e-084858814GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR52N1 OR10Z1

4.51e-085248814GO:0009593
GeneOntologyBiologicalProcesssensory perception

GJA3 OR52R1 MYO3A GJB2 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR1E3 OR8H1 SLC24A1 OR5K1 OR2B6 OR56B4 OR13J1 OR52N1 OR10Z1 ITPR3

9.94e-0810728819GO:0007600
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR52N1 OR10Z1

1.64e-075828814GO:0050906
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR52R1 OR2AK2 CALCR OR2B2 OR2T27 OR9Q1 LRRK2 OR1E1 ARHGEF12 OR1E3 OR8H1 OR5K1 OR2B6 ADGRF1 GPR162 OR56B4 OR13J1 OR52N1 OR10Z1 ITPR1 ITPR3

2.91e-0713958821GO:0007186
GeneOntologyBiologicalProcessdetection of stimulus

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR52N1 OR10Z1

2.14e-067228814GO:0051606
GeneOntologyCellularComponentplatelet dense tubular network membrane

ITPR1 ITPR2 ITPR3

6.15e-069893GO:0031095
GeneOntologyCellularComponentplatelet dense tubular network

ITPR1 ITPR2 ITPR3

1.20e-0511893GO:0031094
MousePhenomyelofibrosis

CLCN7 NBEAL2 ESR2

1.18e-0510663MP:0011747
DomainOlfact_rcpt

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR52N1 OR10Z1

2.82e-083938613IPR000725
DomainInsP3_rcpt-bd

ITPR1 ITPR2 ITPR3

9.43e-083863IPR000493
DomainARM-type_fold

TNPO1 NBEAL1 TNPO2 NBEAL2 MROH2B LRRK2 CAB39L HEATR1 WDFY4 ITPR1 ITPR2

4.35e-073398611IPR016024
DomainRIH_assoc

ITPR1 ITPR2 ITPR3

1.87e-066863PF08454
DomainRIH_assoc-dom

ITPR1 ITPR2 ITPR3

1.87e-066863IPR013662
DomainRIH_dom

ITPR1 ITPR2 ITPR3

1.87e-066863IPR000699
DomainIns145_P3_rcpt

ITPR1 ITPR2 ITPR3

1.87e-066863IPR014821
DomainRyanodine_recept-rel

ITPR1 ITPR2 ITPR3

1.87e-066863IPR015925
Domain-

ITPR1 ITPR2 ITPR3

1.87e-0668631.25.10.30
DomainRYDR_ITPR

ITPR1 ITPR2 ITPR3

1.87e-066863PF01365
DomainIns145_P3_rec

ITPR1 ITPR2 ITPR3

1.87e-066863PF08709
DomainGPCR_Rhodpsn_7TM

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR8H1 OR5K1 OR2B6 GPR162 OR56B4 OR13J1 OR52N1 OR10Z1

2.13e-066708614IPR017452
Domain7tm_1

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR8H1 OR5K1 OR2B6 GPR162 OR56B4 OR13J1 OR52N1 OR10Z1

2.40e-066778614PF00001
DomainG_PROTEIN_RECEP_F1_1

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR8H1 OR5K1 OR2B6 GPR162 OR56B4 OR13J1 OR52N1 OR10Z1

2.75e-066858614PS00237
DomainG_PROTEIN_RECEP_F1_2

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR8H1 OR5K1 OR2B6 GPR162 OR56B4 OR13J1 OR52N1 OR10Z1

3.05e-066918614PS50262
DomainGPCR_Rhodpsn

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR8H1 OR5K1 OR2B6 GPR162 OR56B4 OR13J1 OR52N1 OR10Z1

3.10e-066928614IPR000276
DomainPH-BEACH_dom

NBEAL1 NBEAL2 WDFY4

5.19e-068863IPR023362
Domain-

NBEAL1 NBEAL2 WDFY4

5.19e-0688632.30.29.40
DomainPH_BEACH

NBEAL1 NBEAL2 WDFY4

5.19e-068863PS51783
DomainBEACH_dom

NBEAL1 NBEAL2 WDFY4

7.76e-069863IPR000409
DomainBEACH

NBEAL1 NBEAL2 WDFY4

7.76e-069863PS50197
DomainBeach

NBEAL1 NBEAL2 WDFY4

7.76e-069863PF02138
Domain-

NBEAL1 NBEAL2 WDFY4

7.76e-0698631.10.1540.10
DomainBeach

NBEAL1 NBEAL2 WDFY4

7.76e-069863SM01026
DomainMIR

ITPR1 ITPR2 ITPR3

1.11e-0510863PS50919
DomainMIR

ITPR1 ITPR2 ITPR3

1.11e-0510863PF02815
DomainMIR

ITPR1 ITPR2 ITPR3

1.11e-0510863SM00472
DomainMIR_motif

ITPR1 ITPR2 ITPR3

1.11e-0510863IPR016093
DomainPH_dom-like

FRMD6 NBEAL1 FARP1 NBEAL2 MTMR2 ARHGEF12 FGD1 WDFY4 CIT FGD3

2.59e-054268610IPR011993
DomainARM-like

TNPO1 TNPO2 NBEAL2 MROH2B LRRK2 CAB39L HEATR1 WDFY4

3.44e-05270868IPR011989
Domain-

TNPO1 TNPO2 MROH2B LRRK2 CAB39L HEATR1 WDFY4

7.39e-052228671.25.10.10
DomainDUF4704

NBEAL1 NBEAL2

2.08e-045862IPR031570
DomainDUF4704

NBEAL1 NBEAL2

2.08e-045862PF15787
DomainRhoGEF

FARP1 ARHGEF12 FGD1 FGD3

2.73e-0468864SM00325
DomainRhoGEF

FARP1 ARHGEF12 FGD1 FGD3

3.05e-0470864PF00621
DomainHEAT_REPEAT

TNPO1 TNPO2 MROH2B HEATR1

3.05e-0470864PS50077
DomainDH_2

FARP1 ARHGEF12 FGD1 FGD3

3.05e-0470864PS50010
DomainPH_BEACH

NBEAL1 NBEAL2

3.11e-046862PF14844
DomainDH-domain

FARP1 ARHGEF12 FGD1 FGD3

3.22e-0471864IPR000219
Domain-

FARP1 ARHGEF12 FGD1 FGD3

3.22e-04718641.20.900.10
DomainDHC_N1

DNAH10 DYNC2H1

5.76e-048862PF08385
DomainDynein_heavy_dom-1

DNAH10 DYNC2H1

5.76e-048862IPR013594
DomainGDS_CDC24_CS

FARP1 ARHGEF12 FGD1

7.64e-0439863IPR001331
DomainHEAT

TNPO1 TNPO2 HEATR1

1.40e-0348863PF02985
DomainDynein_heavy_chain_D4_dom

DNAH10 DYNC2H1

1.84e-0314862IPR024317
DomainDynein_HC_stalk

DNAH10 DYNC2H1

1.84e-0314862IPR024743
DomainDynein_heavy_dom-2

DNAH10 DYNC2H1

1.84e-0314862IPR013602
DomainDHC_N2

DNAH10 DYNC2H1

1.84e-0314862PF08393
DomainIMPORTIN_B_NT

TNPO1 TNPO2

1.84e-0314862PS50166
DomainMT

DNAH10 DYNC2H1

1.84e-0314862PF12777
DomainAAA_8

DNAH10 DYNC2H1

1.84e-0314862PF12780
DomainATPase_dyneun-rel_AAA

DNAH10 DYNC2H1

1.84e-0314862IPR011704
DomainAAA_5

DNAH10 DYNC2H1

1.84e-0314862PF07728
DomainDHC_fam

DNAH10 DYNC2H1

2.12e-0315862IPR026983
DomainIBN_N

TNPO1 TNPO2

2.12e-0315862PF03810
DomainDynein_heavy_dom

DNAH10 DYNC2H1

2.12e-0315862IPR004273
DomainDynein_heavy

DNAH10 DYNC2H1

2.12e-0315862PF03028
Domain-

FRMD6 FARP1 MTMR2 ARHGEF12 FGD1 CIT FGD3

2.17e-033918672.30.29.30
DomainIBN_N

TNPO1 TNPO2

2.41e-0316862SM00913
DomainHEAT

TNPO1 TNPO2 HEATR1

2.42e-0358863IPR000357
DomainImportin-beta_N

TNPO1 TNPO2

2.72e-0317862IPR001494
DomainDH_1

FARP1 ARHGEF12 FGD1

3.07e-0363863PS00741
DomainCONNEXINS_1

GJA3 GJB2

3.41e-0319862PS00407
DomainCONNEXINS_2

GJA3 GJB2

3.77e-0320862PS00408
DomainConnexin

GJA3 GJB2

3.77e-0320862IPR000500
DomainConnexin_CCC

GJA3 GJB2

3.77e-0320862IPR019570
DomainConnexin_N

GJA3 GJB2

3.77e-0320862IPR013092
DomainConnexin

GJA3 GJB2

3.77e-0320862PF00029
DomainConnexin_CCC

GJA3 GJB2

3.77e-0320862SM01089
DomainConnexin_CS

GJA3 GJB2

3.77e-0320862IPR017990
DomainCNX

GJA3 GJB2

3.77e-0320862SM00037
PathwayREACTOME_SENSORY_PERCEPTION

OR52R1 MYO3A OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR1E3 OR8H1 SLC24A1 OR5K1 OR2B6 OR56B4 OR13J1 OR52N1 OR10Z1 ITPR3

1.43e-086367217M41834
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR52N1 OR10Z1

1.98e-084177214M4072
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR52R1 OR2AK2 OR2B2 OR2T27 OR9Q1 OR1E1 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR52N1 OR10Z1

7.14e-083897213M14091
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.27e-065723M49000
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

2.53e-066723M47960
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.05e-059723M47852
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.49e-0510723M47661
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

2.05e-0511723M49033
PathwayREACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION

ITPR1 ITPR2 ITPR3

2.05e-0511723M27466
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

3.52e-0513723M47696
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

3.52e-0513723M47751
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

3.52e-0513723M47656
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2 ITPR3

3.52e-0513723MM14553
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2 ITPR3

6.82e-0516723M26945
PathwayREACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION

ITPR1 ITPR2 ITPR3

1.17e-0419723M27423
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.17e-0419723M47760
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.17e-0419723M47733
PathwayWP_GPCRS_OTHER

CALCR OR1E1 OR1E3 OR2B6 GPR162

1.29e-0496725MM15939
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.37e-0420723M47688
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.59e-0421723M47689
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.83e-0422723M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.83e-0422723M47675
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

2.10e-0423723M47676
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR2 ITPR3

2.71e-0425723MM14511
PathwayREACTOME_CA2_PATHWAY

AGO3 ITPR1 ITPR2 ITPR3

2.79e-0462724M27321
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR2 ITPR3

3.42e-0427723M12123
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

3.42e-0427723MM15053
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

3.82e-0428723M924
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR1 ITPR2 ITPR3

5.70e-0432723MM14983
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

ITPR1 ITPR2 ITPR3

8.08e-0436723M1315
PathwayWP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION

ITPR1 ITPR2 ITPR3

8.08e-0436723M39831
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

GJA3 GJB2 ITPR1 ITPR2 ITPR3

9.19e-04147725MM15854
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

GJA3 GJB2 ITPR1 ITPR2 ITPR3

1.04e-03151725M39329
PathwayREACTOME_DAG_AND_IP3_SIGNALING

ITPR1 ITPR2 ITPR3

1.18e-0341723M512
PathwayWP_GPCRS_ODORANT

OR1E1 OR1E3 OR2B6 ADGRF1 GPR162

1.23e-03157725MM15872
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR1 ITPR2 ITPR3

1.27e-0342723M791
PathwayREACTOME_CDC42_GTPASE_CYCLE

FARP1 ARHGEF12 FGD1 FGD3

1.35e-0394724MM15598
PathwayWP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS

ITPR1 ITPR2 ITPR3

1.46e-0344723M39845
PathwaySIG_CHEMOTAXIS

ITPR1 ITPR2 ITPR3

1.55e-0345723M5193
PathwaySIG_BCR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.66e-0346723M8626
PathwayREACTOME_RHO_GTPASE_CYCLE

DLG5 KIDINS220 FARP1 GPS1 ARHGEF12 FGD1 CIT FGD3

2.03e-03450728M27078
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

2.11e-0350723M47951
PathwayREACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK

ARHGEF12 FGD1 FGD3

2.36e-0352723MM14743
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

ITPR1 ITPR2 ITPR3

2.49e-0353723MM15716
PathwayREACTOME_ION_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

2.63e-0354723M27460
PathwayREACTOME_ION_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

2.63e-0354723MM15202
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

ITPR1 ITPR2 ITPR3

2.63e-0354723M26911
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

2.77e-0355723M47952
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

ARHGEF12 ITPR1 ITPR2 ITPR3

2.82e-03115724M9387
PathwayREACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK

ARHGEF12 FGD1 FGD3

3.38e-0359723M11215
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR52R1 OR2AK2 OR2B2 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR10Z1

8.69e-11340901211875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR52R1 OR2AK2 OR2B2 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR10Z1

8.69e-11340901211802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR52R1 OR2AK2 OR2B2 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR10Z1

9.61e-11343901232295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR52R1 OR2AK2 OR2B2 OR9Q1 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR10Z1

1.06e-10346901214611657
Pubmed

The human olfactory receptor gene family.

OR52R1 OR2AK2 OR2B2 OR2T27 OR1E1 OR1E3 OR8H1 OR5K1 OR2B6 OR56B4 OR13J1 OR52N1 OR10Z1

1.49e-09541901314983052
Pubmed

Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

ITPR1 ITPR2 ITPR3

1.68e-08390310874040
Pubmed

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

ITPR1 ITPR2 ITPR3

1.68e-0839039808793
Pubmed

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

ITPR1 ITPR2 ITPR3

1.68e-08390320395455
Pubmed

Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.

ITPR1 ITPR2 ITPR3

1.68e-08390317437169
Pubmed

Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.

ITPR1 ITPR2 ITPR3

1.68e-08390318194433
Pubmed

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.

ITPR1 ITPR2 ITPR3

1.68e-08390318547250
Pubmed

Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.

ITPR1 ITPR2 ITPR3

1.68e-08390336350267
Pubmed

IP3 receptors regulate vascular smooth muscle contractility and hypertension.

ITPR1 ITPR2 ITPR3

1.68e-08390327777977
Pubmed

The versatility and universality of calcium signalling.

ITPR1 ITPR2 ITPR3

1.68e-08390311413485
Pubmed

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

1.68e-08390326009177
Pubmed

Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.

ITPR1 ITPR2 ITPR3

1.68e-08390317581770
Pubmed

Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.

ITPR1 ITPR2 ITPR3

1.68e-08390318241669
Pubmed

Receptor-activated single channels in intact human platelets.

ITPR1 ITPR2 ITPR3

1.68e-0839031693919
Pubmed

Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.

ITPR1 ITPR2 ITPR3

1.68e-08390319068129
Pubmed

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

ITPR1 ITPR2 ITPR3

1.68e-08390323955339
Pubmed

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

ITPR1 ITPR2 ITPR3

1.68e-08390331979185
Pubmed

Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.

ITPR1 ITPR2 ITPR3

1.68e-08390324904548
Pubmed

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

1.68e-08390317327232
Pubmed

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.

ITPR1 ITPR2 ITPR3

1.68e-08390316014380
Pubmed

Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.

ITPR1 ITPR2 ITPR3

1.68e-08390317890015
Pubmed

Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

ITPR1 ITPR2 ITPR3

1.68e-08390323983250
Pubmed

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.

ITPR1 ITPR2 ITPR3

1.68e-0839039858485
Pubmed

Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.

ITPR1 ITPR2 ITPR3

1.68e-08390320427533
Pubmed

Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.

ITPR1 ITPR2 ITPR3

6.69e-08490325215520
Pubmed

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.

ITPR1 ITPR2 ITPR3

6.69e-08490321424589
Pubmed

Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.

ITPR1 ITPR2 ITPR3

6.69e-08490328615414
Pubmed

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.

ITPR1 ITPR2 ITPR3

6.69e-08490310828023
Pubmed

IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.

ITPR1 ITPR2 ITPR3

6.69e-08490328419336
Pubmed

Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

6.69e-08490311163362
Pubmed

IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.

ITPR1 ITPR2 ITPR3

6.69e-08490335494252
Pubmed

InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.

ITPR1 ITPR2 ITPR3

1.67e-07590321568942
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

ITPR1 ITPR2 ITPR3

3.33e-07690323463619
Pubmed

Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.

ITPR1 ITPR2 ITPR3

3.33e-07690321762810
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

ITPR1 ITPR2 ITPR3

3.33e-07690320519450
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

ITPR1 ITPR2 ITPR3

3.33e-07690325966694
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

ITPR1 ITPR2 ITPR3

3.33e-07690316844763
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

ITPR1 ITPR2 ITPR3

5.82e-07790311860456
Pubmed

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

ITPR1 ITPR2 ITPR3

5.82e-07790322495310
Pubmed

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.

ITPR1 ITPR2 ITPR3

1.39e-06990325737585
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR2AK2 OR2B2 OR1E1 OR1E3 OR56B4

1.45e-067490515081110
Pubmed

Defining the membrane proteome of NK cells.

KIDINS220 AGO3 CLCN7 NBEAL2 MARCHF6 HEATR1 ATG9A CIT CNOT1 MFSD5 CDKAL1 ITPR1 ITPR2 ITPR3

1.80e-061168901419946888
Pubmed

Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.

ITPR1 ITPR2 ITPR3

2.72e-061190327514653
Pubmed

Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.

ITPR1 ITPR2 ITPR3

5.97e-061490334630045
Pubmed

Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.

OR1E1 OR1E3 OR2B6

5.97e-06149037528109
Pubmed

Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field.

ITPR1 ITPR3 TBX5

5.97e-061490321382375
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

TNPO1 DLG5 KIDINS220 CLCN7 DYNC2H1 FARP1 HEATR1 COASY DDHD2 CDKAL1 SOAT1 ITPR1 ITPR2 ITPR3 HELLS

6.09e-061487901533957083
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

KIDINS220 CLCN7 ATG9A RIC1 CDKAL1 SOAT1 ITPR1 ITPR2 ITPR3

6.56e-0650490934432599
Pubmed

Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.

ITPR2 ITPR3

6.62e-0629029065779
Pubmed

Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.

ITPR2 ITPR3

6.62e-06290217496801
Pubmed

Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor.

ITPR1 ITPR3

6.62e-0629028663526
Pubmed

The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.

ITPR1 ITPR3

6.62e-06290215890645
Pubmed

Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.

ITPR2 ITPR3

6.62e-06290224901844
Pubmed

Transportin-1 and Transportin-2: protein nuclear import and beyond.

TNPO1 TNPO2

6.62e-06290224780099
Pubmed

Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.

ITPR2 ITPR3

6.62e-06290233854148
Pubmed

An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.

ITPR1 ITPR2

6.62e-06290218708078
Pubmed

Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.

ITPR1 ITPR2

6.62e-06290215201137
Pubmed

Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.

ITPR2 ITPR3

6.62e-06290219528657
Pubmed

Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.

ITPR2 ITPR3

6.62e-0629028063813
Pubmed

Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

6.62e-0629028081734
Pubmed

Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.

ITPR1 ITPR2

6.62e-06290223582047
Pubmed

Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.

ITPR1 ITPR3

6.62e-0629021374893
Pubmed

Discs large 5 is required for polarization of citron kinase in mitotic neural precursors.

DLG5 CIT

6.62e-06290220436275
Pubmed

IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.

ITPR2 ITPR3

6.62e-06290216195467
Pubmed

Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.

ITPR2 ITPR3

6.62e-06290215632133
Pubmed

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.

ITPR1 ITPR3

6.62e-06290220813840
Pubmed

Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.

ITPR2 ITPR3

6.62e-06290215713744
Pubmed

Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.

ITPR1 ITPR3

6.62e-0629027559486
Pubmed

Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.

ITPR1 ITPR3

6.62e-06290220843799
Pubmed

Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.

ITPR1 ITPR2

6.62e-06290219120126
Pubmed

The potential prognostic value of connexin 26 and 46 expression in neoadjuvant-treated breast cancer.

GJA3 GJB2

6.62e-06290223374644
Pubmed

Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins.

TNPO1 TNPO2

6.62e-0629029298975
Pubmed

Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling.

ITPR1 ITPR3

6.62e-06290214707143
Pubmed

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.

ITPR1 ITPR2 ITPR3

7.45e-061590328578927
Pubmed

Olfactory receptors and signalling elements in the Grueneberg ganglion.

OR1E1 OR1E3 OR8H1

1.11e-051790316805845
Pubmed

Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.

ITPR2 ITPR3

1.98e-05390221435446
Pubmed

Physical mapping confirms that sheep chromosome 10 has extensive conserved synteny with cattle chromosome 12 and human chromosome 13.

GJA3 GJB2

1.98e-0539028856922
Pubmed

Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney.

ITPR1 ITPR3

1.98e-05390222992961
Pubmed

An Escherichia coli-Based Assay to Assess the Function of Recombinant Human Hemichannels.

GJA3 GJB2

1.98e-05390227789753
Pubmed

Assignment of connexin 26 (GJB2) and 46 (GJA3) genes to human chromosome 13q11-->q12 and mouse chromosome 14D1-E1 by in situ hybridization.

GJA3 GJB2

1.98e-0539028978770
Pubmed

Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.

ITPR1 ITPR3

1.98e-05390212032348
Pubmed

Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability.

ITPR1 ITPR2

1.98e-05390232320395
Pubmed

Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins.

GJA3 GJB2

1.98e-05390227143357
Pubmed

Ubiquitination and proteasomal degradation of endogenous and exogenous inositol 1,4,5-trisphosphate receptors in alpha T3-1 anterior pituitary cells.

ITPR1 ITPR3

1.98e-05390212421829
Pubmed

Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.

ITPR1 ITPR2

1.98e-05390223223241
Pubmed

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.

TNPO1 TNPO2

1.98e-05390220606625
Pubmed

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.

ITPR1 ITPR3

1.98e-05390218250332
Pubmed

Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells.

KIDINS220 ITPR3

1.98e-05390218539593
Pubmed

Involvement of transportin 2-mediated HuR import in muscle cell differentiation.

TNPO1 TNPO2

1.98e-05390217475777
Pubmed

The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity.

ITPR1 ITPR2 ITPR3

2.49e-052290311696558
Pubmed

Tagging genes with cassette-exchange sites.

TNPO2 MARCHF6 ARHGEF12 SIK1 MED23 CIT CDKAL1

2.72e-0533590715741177
Pubmed

Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

ITPR1 ITPR2 ITPR3

3.26e-052490310843712
Pubmed

Distribution of genes for gap junction membrane channel proteins on human and mouse chromosomes.

GJA3 GJB2

3.96e-0549021849321
Pubmed

Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor.

ITPR2 ITPR3

3.96e-05490217925404
Pubmed

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.

ITPR1 ITPR2

3.96e-05490221818117
Pubmed

IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis.

ITPR2 ITPR3

3.96e-05490226193638
InteractionIRAG1 interactions

USP25 ITPR1 ITPR2 ITPR3

2.24e-0714804int:IRAG1
InteractionCDC42 interactions

DLG5 KIDINS220 AGO3 CLCN7 DYNC2H1 FARP1 ESR2 LRRK2 ARHGEF12 FGD1 HEATR1 CIT CNOT1 CDKAL1 SOAT1 FGD3 ITPR1 ITPR2 ITPR3

7.30e-0713238019int:CDC42
InteractionNUP155 interactions

TNPO1 KIDINS220 CLCN7 NBEAL1 CIT CNOT1 CDKAL1 SOAT1 ITPR1 ITPR2 ITPR3

2.80e-064778011int:NUP155
InteractionTRPC1 interactions

CIT ITPR1 ITPR2 ITPR3

5.07e-0629804int:TRPC1
InteractionB3GAT1 interactions

CLCN7 TNPO2 FARP1 RIC1 CDKAL1 SOAT1 ITPR1 ITPR2 ITPR3

1.83e-05377809int:B3GAT1
InteractionCCR6 interactions

DYM MFSD5 ITPR2 TMEM63A ITPR3

2.78e-0589805int:CCR6
InteractionRAB29 interactions

LRRK2 ATG9A ITPR1 ITPR2 ITPR3

2.78e-0589805int:RAB29
InteractionMYO6 interactions

MYO3A FBXO22 CLCN7 ESR2 CHEK2 USP25 ARHGEF12 WDFY4 CIT

2.81e-05398809int:MYO6
InteractionTESPA1 interactions

ITPR1 ITPR2 ITPR3

3.25e-0516803int:TESPA1
InteractionCD40 interactions

TNPO1 DYM TNPO2 NBEAL2 HEATR1 MFSD5

3.28e-05153806int:CD40
InteractionCAPZA2 interactions

FARP1 ESR2 LRRK2 ATF3 CIT CNOT1 ITPR1 ITPR2 ITPR3

5.12e-05430809int:CAPZA2
InteractionFBXO22 interactions

FBXO22 NBEAL2 GPS1 CHEK2 SIK1 MORC2 CIT CNOT1 RIC1 HELLS

5.37e-055408010int:FBXO22
InteractionGJD3 interactions

DLG5 KIDINS220 CLCN7 RIC1 CDKAL1 SOAT1 ITPR1 ITPR2 ITPR3

7.77e-05454809int:GJD3
InteractionGPR182 interactions

DYM KIDINS220 NBEAL2 CHEK2 HEATR1 MED23 GPAT2 SOAT1 HELLS

7.90e-05455809int:GPR182
InteractionSHISAL1 interactions

SLC41A2 GJB2 GIMAP5 MFSD5

9.48e-0560804int:SHISAL1
InteractionELOVL5 interactions

CLCN7 DDHD2 RIC1 CDKAL1 SOAT1 ITPR1 ITPR2 ITPR3

9.80e-05364808int:ELOVL5
InteractionTRPC4 interactions

ITPR1 ITPR2 ITPR3

1.01e-0423803int:TRPC4
InteractionRHOC interactions

DLG5 KIDINS220 CLCN7 FARP1 ESR2 ARHGEF12 CIT CDKAL1 SOAT1 ITPR1

1.03e-045848010int:RHOC
InteractionGJB3 interactions

GJA3 GJB2 GIMAP5

1.15e-0424803int:GJB3
InteractionTNRC6A interactions

TNPO1 DLG5 AGO3 TNPO2 ESR2 MED23 CNOT1

1.24e-04280807int:TNRC6A
InteractionRASEF interactions

ITPR1 ITPR2 ITPR3

1.30e-0425803int:RASEF
InteractionTRPC2 interactions

ITPR1 ITPR3

1.54e-045802int:TRPC2
InteractionSORT1 interactions

ESR2 MARCHF6 CD70 MORC2 WDFY4 B4GALT4

1.79e-04208806int:SORT1
InteractionMYH9 interactions

TNPO1 AGO3 ESR2 GPS1 LRRK2 USP25 ATG9A WDFY4 CIT ITPR2 ITPR3

1.86e-047548011int:MYH9
InteractionBBOX1 interactions

ITPR1 ITPR2 ITPR3

2.04e-0429803int:BBOX1
InteractionC3orf52 interactions

KIDINS220 CLCN7 ATG9A CDKAL1 ITPR2 TMEM63A ITPR3

2.10e-04305807int:C3orf52
InteractionMYL12B interactions

MYO3A ESR2 LRRK2 WDFY4 CIT

2.23e-04138805int:MYL12B
InteractionMROH2B interactions

MROH2B CIT

2.31e-046802int:MROH2B
InteractionNUP98 interactions

TNPO1 TNPO2 ESR2 CD70 CIT TBX5

2.42e-04220806int:NUP98
InteractionRHOA interactions

DLG5 KIDINS220 CLCN7 FARP1 LRRK2 ARHGEF12 HEATR1 ATG9A CIT CDKAL1 SOAT1 ITPR1 ITPR2 ITPR3

2.43e-0411998014int:RHOA
InteractionLYPD3 interactions

CLCN7 TNPO2 ESR2 CHEK2 HELLS

2.46e-04141805int:LYPD3
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR1 ITPR2 ITPR3

5.80e-083713297
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEAL1 NBEAL2 WDFY4

4.79e-0697131230
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

FARP1 ARHGEF12 FGD1 FGD3

1.31e-0466714722
GeneFamilyOlfactory receptors, family 2

OR2AK2 OR2B2 OR2T27 OR2B6

1.02e-03113714149
GeneFamilyArmadillo repeat containing|Importins

TNPO1 TNPO2

2.23e-0318712596
GeneFamilyGap junction proteins

GJA3 GJB2

3.34e-0322712314
ToppCellBAL-Control-Lymphocyte-B-B_cell|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ESR2 LRRK2 CD70 PABPC1L ATF3 ITPR3

2.28e-06190896da7341a8a423e5fe4d8e733d8e50c10a3318ac1c
ToppCellBAL-Control-Lymphocyte-B-B_cell-B_cell|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ESR2 LRRK2 CD70 PABPC1L ATF3 ITPR3

2.28e-0619089642312f7d79fe889397d32910b625793e2535cc26
ToppCellBAL-Control-Lymphocyte-B-B_cell-B_cell-B_activate-7|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ESR2 LRRK2 CD70 PABPC1L ATF3 ITPR3

2.28e-06190896682418a7a2096743112eae3790d40e7e600612c0
DrugPiribedil hydrochloride [78213-63-5]; Down 200; 12uM; MCF7; HT_HG-U133A

DLG5 KIDINS220 COQ4 NBEAL2 ATF3 TMEM63A ITPR3

1.16e-051958973512_DN
DrugLisuride (S)(-) [18016-80-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A

CALCR MARCHF6 FGD1 SLC24A1 OR2B6 CDKAL1 TBX5

1.16e-051958975028_UP
DrugVerapamyl hydrochloride [152-11-4]; Up 200; 8.2uM; MCF7; HT_HG-U133A

CALCR CLCN7 TNPO2 NBEAL2 OR2B6 MASP2 TMEM63A

1.28e-051988975387_UP
Drugadenophostin A

ITPR2 ITPR3

1.51e-052892ctd:C085029
DrugIsocaffeine

ITPR1 ITPR3

1.51e-052892CID000001326
Drugadenophostin B

ITPR1 ITPR3

1.51e-052892CID000656722
Drugbenzene 1,2,4-trisphosphate

ITPR1 ITPR3

1.51e-052892CID000192376
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR1 ITPR2 ITPR3

5.16e-0612863DOID:1441 (implicated_via_orthology)
DiseaseAnoxic Encephalopathy

ITPR1 ITPR2

8.40e-062862C0003132
DiseaseBrain Hypoxia

ITPR1 ITPR2

8.40e-062862C1527348
DiseaseAnoxia of brain

ITPR1 ITPR2

8.40e-062862C0995195
DiseaseHypoxic Brain Damage

ITPR1 ITPR2

8.40e-062862C1140716
Diseaseintellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies (implicated_via_orthology)

TNPO1 TNPO2

8.40e-062862DOID:0081262 (implicated_via_orthology)
DiseaseCharcot-Marie-Tooth disease (implicated_via_orthology)

MTMR2 FGD1 FGD3

4.63e-0524863DOID:10595 (implicated_via_orthology)
DiseaseCharcot-Marie-Tooth disease type 4H (implicated_via_orthology)

FGD1 FGD3

5.02e-054862DOID:0110192 (implicated_via_orthology)
DiseaseX-linked Aarskog syndrome (implicated_via_orthology)

FGD1 FGD3

5.02e-054862DOID:6683 (implicated_via_orthology)
Diseaseresponse to methotrexate, drug-induced liver injury

MYO3A FARP1 ARHGEF12

5.92e-0526863EFO_0004228, GO_0031427
Diseaseobesity (implicated_via_orthology)

DNAH10 ESR2 ITPR1 ITPR2 ITPR3

4.23e-04215865DOID:9970 (implicated_via_orthology)
Diseasecutaneous Leishmaniasis

DYM CALCR

9.81e-0416862EFO_0005046
Diseasereceptive language perception

TNPO1 TBX5

1.39e-0319862EFO_0005686
DiseaseOvarian Serous Adenocarcinoma

MYO3A LRRK2

2.04e-0323862C1335177

Protein segments in the cluster

PeptideGeneStartEntry
VEYISAHPHILFMLL

CAB39L

116

Q9H9S4
RYLPTDTLLNHMLIH

ADNP

496

Q9H2P0
IIHMLREYLERLGQH

ANKRD54

241

Q6NXT1
ILVPHRNREKHLMYL

B4GALT4

126

O60513
LLAYRIILVFHHMAQ

ADGRF1

681

Q5T601
HLLYIIHGPVMAALV

CALCR

296

P30988
YYILLHIMLGEILRH

APOBEC3G

181

Q9HC16
TPALLVAMHVAYRRH

GJB2

86

P29033
HAVDVVLRHLPSMKY

AGO3

161

Q9H9G7
MLLAVQYLHENGIIH

CHEK2

331

O96017
LRIHRDGIYMVHIQV

CD70

96

P32970
HELLPNHLMETLYSR

C6orf201

6

Q7Z4U5
YLAELILAVHSVHLM

CIT

201

O14578
LAHEYPDLVHKVIMI

ABHD8

261

Q96I13
IPEDLHRHYIQTMQE

ARHGEF12

456

Q9NZN5
MHYLIRVEPFTTLHI

NBEAL1

2106

Q6ZS30
YFPHVLELMLHEVLE

RIC1

856

Q4ADV7
TFLRVLIHLIMHDYP

ITPR2

1056

Q14571
LRVLIHLTMHDYAPL

ITPR3

1056

Q14573
ELENVRILPHTVLYM

FBXO22

91

Q8NEZ5
IHLIRLNTRLHTPMY

OR2AK2

61

Q8NG84
ICRPLHYSVIMHQRL

OR2B6

126

P58173
IILILMDHQLHAPMY

OR9Q1

46

Q8NGQ5
VLHMLHQILTPFLLR

HELLS

436

Q9NRZ9
HDYMRNIVHLPVFLN

KIDINS220

831

Q9ULH0
PVYDLLLEMLNAHVL

ESR2

486

Q92731
IYQLMLHSLDPLREV

SLC24A1

671

O60721
RHMLFPPLERVHYLQ

GPR162

391

Q16538
LRVLLHLTMHDYPPL

ITPR1

1071

Q14643
LYDMHIQLQSVPFLH

CLCN7

601

P51798
NLLLDMYLAPHVRTL

GPS1

351

Q13098
RMHHIQPHYRVQLLS

MED23

611

Q9ULK4
IILHNPKLMVHYQPV

DDHD2

161

O94830
ERLHHMHIYPIVIFI

DLG5

1826

Q8TDM6
HVPLLIVLDSYMRVA

LRRK2

61

Q5S007
QEMIHLPIYRHLRRF

MARCHF6

466

O60337
NHVLYPVASMRHLEL

MTMR2

561

Q13614
HHMLEPVQRVPRYEL

FGD3

291

Q5JSP0
IILIHIDSRLHTPMY

OR2T27

46

Q8NH04
ICQPLRYHVLMSHRL

OR13J1

126

Q8NGT2
QMIGERLYPLIHDVH

PABPC1L

546

Q4VXU2
LIYILLKHMVDRHNL

TMEM63A

636

O94886
PQEERHDVIALYHRM

MMEL1

321

Q495T6
VALIFTHRRLHTPMY

OR5K1

46

Q8NHB7
VLYIDPRMRIFIHGH

MORC2

246

Q9Y6X9
IIAIRLDSHLHTPMY

OR10Z1

46

Q8NGY1
ALLRVKHLMLLHYEI

GIMAP5

271

Q96F15
VIRIDHTLHEPMYLF

OR52R1

51

Q8NGF1
LHEPMYHLLGILAVV

OR56B4

61

Q8NH76
HRLYMNLQPVLRHIR

FRMD6

321

Q96NE9
DHYPESRMLHLLDII

DYNC2H1

241

Q8NCM8
DMENLVLPILEILYH

DYM

371

Q7RTS9
FLLRPLHRLMHYKQV

FARP1

681

Q9Y4F1
YLLLAQEHLRHFLEM

FAM83C

201

Q9BQN1
HLEEMAKILNHPRVY

CDKAL1

301

Q5VV42
QLLRVILAHIHYMPD

ATG9A

436

Q7Z3C6
LVVLPYQMLLHAATR

DDX11L8

366

A8MPP1
ELYRQILLLMHLLPQ

GPAT2

586

Q6NUI2
IQRYREVHDMLHTLL

COQ4

156

Q9Y3A0
HLIYMLNLHRPTCIV

ATF3

141

P18847
LARNLMYVDIPIVDH

MASP2

581

O00187
LLHYMLPHLVVSIIH

HEATR1

346

Q9H583
IYLGHVLHIVRMEEK

GJA3

91

Q9Y6H8
IAYEVMRHPLIKDEH

DNAH10

1031

Q8IVF4
RYHLQPMHLLSLAVL

MFSD5

306

Q6N075
IVLIRLDSHLHMPMY

OR1E3

46

Q8WZA6
ICRPLHYSIIMHQRL

OR2B2

126

Q9GZK3
LPRHMQEALRRLHYV

IL4I1

336

Q96RQ9
ILIIRLDLQLHTPMY

OR8H1

46

Q8NGG4
IVLIRLDSHLHTPMY

OR1E1

46

P30953
IPLHIHIIMANLYLL

OR52N1

271

Q8NH53
HPDINRAHLFLLLMV

RTL1

401

A6NKG5
LLLMVRVNPYHSVAV

RTL1

411

A6NKG5
DHIRTIYHMFIALLI

SOAT1

136

P35610
IILNSMHKYQPRLHI

TBX5

171

Q99593
EDPQLHAQAYVRLHM

NBEAL2

1591

Q6ZNJ1
HHMLEPVQRIPRYEL

FGD1

511

P98174
IYREVQLMKLLNHPH

SIK1B

71

A0A0B4J2F2
IYREVQLMKLLNHPH

SIK1

71

P57059
VIPGHLIFLYTIHLM

SLC41A2

476

Q96JW4
LLEILGTIYHHMPVL

MROH2B

1046

Q7Z745
MLHEYLVNHLPLAVN

CILP

1041

O75339
RLVNHTLYVHLQPGM

COASY

31

Q13057
HHMTELPLRFLYIAL

LINC02915

56

Q8N8G6
QQLPYHRIFIMLLLE

CNOT1

1986

A5YKK6
LLLVLHYFVELLSHM

TRAM1L1

221

Q8N609
EPRTHHPYLLEMLLA

NUFIP1

446

Q9UHK0
HPYLLEMLLAPDIRH

NUFIP1

451

Q9UHK0
DRLIPHMHSIIQYML

TNPO2

246

O14787
IMVRLLPRLYHEDHP

WDFY4

836

Q6ZS81
MIQVPYRLHAVLVHE

USP25

586

Q9UHP3
DRLLPHMHNIVEYML

TNPO1

256

Q92973
LIRHQIKYLGLMEHL

MYO1H

611

Q8N1T3
LIAYILHEALMGLQH

MYO3A

126

Q8NEV4