Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	CLOCK-BMAL transcription complex	PASD1 NPAS2	1.10e-04	5	70	2	GO:1990513
GeneOntologyCellularComponent	transcription regulator complex	MED25 POU2AF1 DAZAP2 BCL9 KLF4 SPEN SMAD2 PASD1 NPAS2	1.62e-04	596	70	9	GO:0005667
GeneOntologyCellularComponent	RNA polymerase II transcription regulator complex	MED25 POU2AF1 BCL9 SMAD2 PASD1 NPAS2	3.00e-04	272	70	6	GO:0090575
GeneOntologyCellularComponent	nuclear protein-containing complex	KMT2C RBBP5 DROSHA AHCTF1 BCL7C MED25 POU2AF1 BCL9 SNRPB2 RPA1 SMAD2 PASD1 NPAS2	5.80e-04	1377	70	13	GO:0140513
GeneOntologyCellularComponent	SCAR complex	WASF2 WASF3	7.14e-04	12	70	2	GO:0031209
GeneOntologyCellularComponent	MLL3/4 complex	KMT2C RBBP5	7.14e-04	12	70	2	GO:0044666
GeneOntologyCellularComponent	ESCRT I complex	VPS37C VPS37A	7.14e-04	12	70	2	GO:0000813
Domain	SCAR/WAVE_fam	WASF2 WASF3	4.14e-05	3	70	2	IPR028288
Domain	Mod_r	VPS37C VPS37A	8.27e-05	4	70	2	PF07200
Domain	Mod_r	VPS37C VPS37A	8.27e-05	4	70	2	IPR009851
Domain	VPS37_C	VPS37C VPS37A	8.27e-05	4	70	2	PS51314
Domain	Homeobox_antennapedia	HOXA4 HOXD4	8.92e-04	12	70	2	IPR017995
Domain	WH2	WASF2 WASF3	1.22e-03	14	70	2	SM00246
Domain	WH2	WASF2 WASF3	1.61e-03	16	70	2	PF02205
Domain	AT_hook	KMT2C AHCTF1	1.61e-03	16	70	2	PF02178
Domain	Homeobox_Antennapedia_CS	HOXA4 HOXD4	2.78e-03	21	70	2	IPR001827
Domain	WH2_dom	WASF2 WASF3	2.78e-03	21	70	2	IPR003124
Domain	WH2	WASF2 WASF3	3.62e-03	24	70	2	PS51082
Domain	ANTENNAPEDIA	HOXA4 HOXD4	3.62e-03	24	70	2	PS00032
Domain	AT_hook	KMT2C AHCTF1	4.57e-03	27	70	2	SM00384
Domain	AT_hook_DNA-bd_motif	KMT2C AHCTF1	4.57e-03	27	70	2	IPR017956
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TPST2 KMT2C ERBB2 C2CD3 MYO1E ZNF341 ANXA11 PKD1 ADGRB2 PAPLN BCL9 KLF4 WNK1 SPEN	3.63e-08	1105	70	14	35748872
Pubmed	Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor.	CD6 ALCAM	3.99e-06	2	70	2	16818773
Pubmed	Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens.	CD6 ALCAM	3.99e-06	2	70	2	16818742
Pubmed	High expression of the vacuole membrane protein 1 (VMP1) is a potential marker of poor prognosis in HER2 positive breast cancer.	VMP1 ERBB2	3.99e-06	2	70	2	31442252
Pubmed	Polymorphisms in the CD6-ALCAM axis may modulate psoriasis risk and outcomes.	CD6 ALCAM	3.99e-06	2	70	2	38580538
Pubmed	The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses.	CD6 ALCAM	3.99e-06	2	70	2	34981775
Pubmed	Critical Role of CD6highCD4+ T Cells in Driving Th1/Th17 Cell Immune Responses and Mucosal Inflammation in IBD.	CD6 ALCAM	3.99e-06	2	70	2	30395204
Pubmed	Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction.	CD6 ALCAM	3.99e-06	2	70	2	26146185
Pubmed	CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes.	CD6 ALCAM	3.99e-06	2	70	2	9436462
Pubmed	The Wiskott-Aldrich syndrome protein (WASP) family.	WASF2 WASF3	3.99e-06	2	70	2	11246027
Pubmed	Genetic variations in the host dependency factors ALCAM and TPST2 impact HIV-1 disease progression.	TPST2 ALCAM	3.99e-06	2	70	2	32287057
Pubmed	Clinical significance of CD166 and HER-2 in different types of gastric cancer.	ERBB2 ALCAM	3.99e-06	2	70	2	37537510
Pubmed	The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site.	CD6 ALCAM	3.99e-06	2	70	2	7543097
Pubmed	CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction.	CD6 ALCAM	3.99e-06	2	70	2	20726988
Pubmed	Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells.	CD6 ALCAM	3.99e-06	2	70	2	16352806
Pubmed	Relevance of CD6-mediated interactions in T cell activation and proliferation.	CD6 ALCAM	3.99e-06	2	70	2	15294938
Pubmed	Cellular signaling in macrophage migration and chemotaxis.	WASF2 WASF3	3.99e-06	2	70	2	11073096
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	HOXA4 HOXD4 IRF2BP1 TRPS1 POU2AF1 DAZAP2 NFKBIZ SPEN SMAD2 NPAS2	9.98e-06	877	70	10	20211142
Pubmed	WASF3 provides the conduit to facilitate invasion and metastasis in breast cancer cells through HER2/HER3 signaling.	ERBB2 WASF3	1.20e-05	3	70	2	26804171
Pubmed	Genomic organization and expression profile of the human and mouse WAVE gene family.	WASF2 WASF3	1.20e-05	3	70	2	12856283
Pubmed	TFG-1 function in protein secretion and oncogenesis.	SEC16B TFG	1.20e-05	3	70	2	21478858
Pubmed	Characterization of the WAVE1 knock-out mouse: implications for CNS development.	WASF2 WASF3	1.20e-05	3	70	2	12716942
Pubmed	Characterization of mouse ALCAM (CD166): the CD6-binding domain is conserved in different homologs and mediates cross-species binding.	CD6 ALCAM	1.20e-05	3	70	2	9209500
Pubmed	Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage.	WASF2 WASF3	1.20e-05	3	70	2	15670045
Pubmed	Gene variation impact on prostate cancer progression: Lymphocyte modulator, activation, and cell adhesion gene variant contribution.	CD6 ALCAM	1.20e-05	3	70	2	35767366
Pubmed	SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development.	WASF2 WASF3	1.20e-05	3	70	2	9732292
Pubmed	WAVE/Scars in platelets.	WASF2 WASF3	1.20e-05	3	70	2	15280206
Pubmed	Nuclear accumulation of an uncapped RNA produced by Drosha cleavage of a transcript encoding miR-10b and HOXD4.	HOXD4 DROSHA	1.20e-05	3	70	2	21991333
Pubmed	Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway.	WNK1 SMAD2	2.39e-05	4	70	2	17392271
Pubmed	Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion.	WASF2 WASF3	2.39e-05	4	70	2	19200726
Pubmed	Forward spreading in the establishment of a vertebrate Hox expression boundary: the expression domain separates into anterior and posterior zones, and the spread occurs across implanted glass barriers.	HOXA4 HOXD4	2.39e-05	4	70	2	7912569
Pubmed	The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery.	WASF2 WASF3	2.39e-05	4	70	2	17664349
Pubmed	Mouse homeo-genes within a subfamily, Hox-1.4, -2.6 and -5.1, display similar anteroposterior domains of expression in the embryo, but show stage- and tissue-dependent differences in their regulation.	HOXA4 HOXD4	2.39e-05	4	70	2	2576400
Pubmed	Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed.	HOXA4 HOXD4	2.39e-05	4	70	2	7628700
Pubmed	The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11.	ERBB2 RNF11	2.39e-05	4	70	2	18724389
Pubmed	Control of IFN-γ production and regulatory function by the inducible nuclear protein IκB-ζ in T cells.	NFKBIZ SMAD2	2.39e-05	4	70	2	26019294
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C RBBP5	2.39e-05	4	70	2	24081332
Pubmed	Modulation of CD6 function through interaction with Galectin-1 and -3.	CD6 ALCAM	2.39e-05	4	70	2	24945728
Pubmed	Functional proteomics mapping of a human signaling pathway.	IRF2BP1 ZNF341 DROSHA PKD1 DAZAP2 RNF216 RNF11 SMAD2	2.48e-05	591	70	8	15231748
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TMEM61 HSH2D BCL9 SHISA4 WNK1 SPEN RNF11	2.58e-05	430	70	7	35044719
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	VPS37C KL AHCTF1 ANXA11 PKD1 SLC35F6 ALCAM SPEN PLSCR1 RNF11	3.51e-05	1016	70	10	19056867
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	KMT2C IRF2BP1 MYO1E RC3H1 AHCTF1 BCL9 TFG	3.79e-05	457	70	7	32344865
Pubmed	WAVE2 is required for directed cell migration and cardiovascular development.	WASF2 WASF3	3.98e-05	5	70	2	12879075
Pubmed	Role of RbBP5 and H3K4me3 in the vicinity of Snail transcription start site during epithelial-mesenchymal transition in prostate cancer cell.	RBBP5 SMAD2	3.98e-05	5	70	2	27566588
Pubmed	Identification and characterization of a PDZ protein that interacts with activin type II receptors.	MAGI2 SMAD2	3.98e-05	5	70	2	10681527
Pubmed	Krüppel-like factors in hepatocellular carcinoma.	KLF17 KLF4	3.98e-05	5	70	2	25652467
Pubmed	The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.	HOXA4 HOXD4	3.98e-05	5	70	2	2569969
Pubmed	FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation.	WASF2 WASF3	3.98e-05	5	70	2	14697212
Pubmed	Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling.	ERBB2 SMAD2	3.98e-05	5	70	2	28650473
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	VMP1 RBBP5 WASF2 AHCTF1 TRPS1 GRINA	5.67e-05	332	70	6	37433992
Pubmed	HIV-1 Nef drives macrophages into hiding.	WASF2 WASF3	5.96e-05	6	70	2	25745180
Pubmed	Novel roles of Pkd2 in male reproductive system development.	PKD1 SMAD2	5.96e-05	6	70	2	24951251
Pubmed	HIV-1 reprograms the migration of macrophages.	WASF2 WASF3	5.96e-05	6	70	2	25527710
Pubmed	Interaction network of human early embryonic transcription factors.	KMT2C RBBP5 BCL7C TRPS1 BCL9 SPEN	7.71e-05	351	70	6	38297188
Pubmed	Sequence and embryonic expression of the murine Hox-3.5 gene.	HOXA4 HOXD4	8.33e-05	7	70	2	1363091
Pubmed	Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations.	HOXA4 HOXD4	8.33e-05	7	70	2	8660891
Pubmed	Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex.	KMT2C RBBP5	8.33e-05	7	70	2	26324722
Pubmed	Conservation and divergence of patterns of expression and lineage-specific transcripts in orthologues and paralogues of the mouse Hox-1.4 gene.	HOXA4 HOXD4	8.33e-05	7	70	2	7680626
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2C RBBP5	8.33e-05	7	70	2	30604749
Pubmed	Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.	VPS37C VPS37A	8.33e-05	7	70	2	15509564
Pubmed	The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex.	VPS37C VPS37A	8.33e-05	7	70	2	24284069
Pubmed	Pkd1 is required for male reproductive tract development.	PKD1 SMAD2	8.33e-05	7	70	2	23933588
Pubmed	Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.	WASF2 WASF3	1.11e-04	8	70	2	10381382
Pubmed	Hox genes regulate the onset of Tbx5 expression in the forelimb.	HOXA4 HOXD4	1.11e-04	8	70	2	22872086
Pubmed	Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling.	TMEM61 PKD1	1.11e-04	8	70	2	29716997
Pubmed	The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.	VPS37C VPS37A	1.11e-04	8	70	2	22405001
Pubmed	Retinoic acid regulates a subset of Cdx1 function in vivo.	HOXA4 HOXD4	1.11e-04	8	70	2	14660544
Pubmed	Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.	RC3H1 NFKBIZ	1.11e-04	8	70	2	25282160
Pubmed	Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex.	WASF2 WASF3	1.11e-04	8	70	2	11146629
Pubmed	Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling.	IRF2BP1 SMAD2	1.11e-04	8	70	2	18511908
Pubmed	Human transcription factor protein interaction networks.	KMT2C IRF2BP1 RBBP5 RC3H1 BCL7C TRPS1 ETV5 BCL9 KLF4 SPEN RPA1	1.26e-04	1429	70	11	35140242
Pubmed	Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.	KMT2C MED25 SMAD2	1.27e-04	48	70	3	27703004
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2C RBBP5	1.42e-04	9	70	2	22665483
Pubmed	Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding.	VPS37C VPS37A	1.42e-04	9	70	2	18005716
Pubmed	Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.	HOXA4 HOXD4	1.42e-04	9	70	2	12242306
Pubmed	UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.	VPS37C VPS37A	1.42e-04	9	70	2	21757351
Pubmed	Region-specific gastrointestinal Hox code during murine embryonal gut development.	HOXA4 HOXD4	1.42e-04	9	70	2	11869294
Pubmed	Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice.	HOXA4 HOXD4	1.42e-04	9	70	2	9043087
Pubmed	A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission.	VPS37C VPS37A	1.42e-04	9	70	2	32424346
Pubmed	Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code.	HOXA4 HOXD4	1.42e-04	9	70	2	10579975
Pubmed	Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2α phosphorylation via protein interactors and actin cytoskeleton.	WASF2 WASF3	1.42e-04	9	70	2	38981622
Pubmed	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.	ERBB2 ZNF341 DAZAP2 PLSCR1 APBB1IP NPAS2	1.61e-04	402	70	6	24722188
Pubmed	The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding.	VPS37C VPS37A	1.78e-04	10	70	2	15218037
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	VMP1 KMT2C RBBP5 DROSHA WASF2 AHCTF1 TRPS1 MED25 SLC35F6 KLF4 SPEN	1.89e-04	1497	70	11	31527615
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	RBBP5 BCL7C TRPS1 BCL9 KLF4	2.11e-04	268	70	5	33640491
Pubmed	Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies.	SEC16B ETV5	2.17e-04	11	70	2	19812171
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	AHCTF1 TRPS1 ETV5 NFKBIZ KLF17 KLF4 SMAD2 NPAS2	2.17e-04	808	70	8	20412781
Pubmed	A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.	KMT2C RBBP5 KLF4	2.58e-04	61	70	3	20305087
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2C RBBP5	2.60e-04	12	70	2	27563068
Pubmed	Expression of class I homeobox genes in fetal and adult murine skin.	HOXA4 HOXD4	2.60e-04	12	70	2	8105001
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KMT2C RBBP5	3.07e-04	13	70	2	21502505
Pubmed	Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome.	RNF11 SMAD2	3.07e-04	13	70	2	21574244
Pubmed	The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression.	HOXA4 HOXD4	3.07e-04	13	70	2	8887324
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	KMT2C RBBP5	3.07e-04	13	70	2	17761849
Pubmed	WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.	WASF2 WASF3	3.07e-04	13	70	2	16723544
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	KMT2C ZNF341 PPP4R2 AHCTF1 NFKBIZ KLF4 WNK1 RPA1 SMAD2	3.17e-04	1084	70	9	11544199
Pubmed	The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors.	KMT2C RBBP5	3.58e-04	14	70	2	19136632
Pubmed	Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.	SEC16B ETV5	3.58e-04	14	70	2	19851340
Pubmed	Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis.	ERBB2 ETV5	3.58e-04	14	70	2	14635793
Pubmed	Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1.	ERBB2 PKD1	3.58e-04	14	70	2	16400024
Interaction	PAX8 interactions	KMT2C IRF2BP1 RBBP5 BCL7C TRPS1 POU2AF1 BCL9	1.03e-07	111	69	7	int:PAX8
Interaction	HGS interactions	VMP1 VPS37C VPS37A MED25 POU2AF1 DAZAP2 PRR22 KLF4 TFG RNF11 SMAD2 NPAS2	1.89e-07	523	69	12	int:HGS
Interaction	CRX interactions	VPS37C KMT2C RBBP5 BCL7C TRPS1 BCL9 SPEN TFG NPAS2	2.04e-07	254	69	9	int:CRX
Interaction	SOX9 interactions	KMT2C BCL7C TRPS1 BCL9 SPEN SMAD2	9.98e-07	97	69	6	int:SOX9
Interaction	PEF1 interactions	VPS37C ANXA11 MED25 DAZAP2 RPA1 TFG	1.88e-06	108	69	6	int:PEF1
Interaction	TBXT interactions	KMT2C RBBP5 BCL7C TRPS1 BCL9 SPEN	2.85e-06	116	69	6	int:TBXT
Interaction	PAX9 interactions	VPS37C KMT2C IRF2BP1 TRPS1 BCL9 KLF4	5.51e-06	130	69	6	int:PAX9
Interaction	PDCD6 interactions	VPS37C DROSHA RC3H1 ANXA11 SHISA4 RPA1 TFG	6.23e-06	204	69	7	int:PDCD6
Interaction	NFIB interactions	KMT2C IRF2BP1 BCL7C TRPS1 BCL9 RPA1	9.16e-06	142	69	6	int:NFIB
Interaction	FAM168A interactions	VPS37C RC3H1 DAZAP2 RNF216 TFG PLSCR1	9.16e-06	142	69	6	int:FAM168A
Interaction	FOXI1 interactions	VPS37C KMT2C BCL7C TRPS1 BCL9	1.59e-05	92	69	5	int:FOXI1
Interaction	PLSCR1 interactions	PCED1A VPS37C ANXA11 DAZAP2 TFG PLSCR1	2.72e-05	172	69	6	int:PLSCR1
Interaction	TFG interactions	VPS37C ANXA11 MED25 POU2AF1 DAZAP2 TFG PLSCR1	2.85e-05	258	69	7	int:TFG
Interaction	TLX1 interactions	KMT2C IRF2BP1 BCL7C TRPS1 BCL9 RPA1	3.00e-05	175	69	6	int:TLX1
Interaction	POU2AF1 interactions	VPS37C POU2AF1 TFG SMAD2	4.04e-05	56	69	4	int:POU2AF1
Interaction	HNF4A interactions	KMT2C IRF2BP1 RBBP5 BCL7C TRPS1 SPEN SMAD2	4.28e-05	275	69	7	int:HNF4A
Interaction	TBR1 interactions	KMT2C RBBP5 BCL7C TRPS1 BCL9	4.28e-05	113	69	5	int:TBR1
Interaction	MYOD1 interactions	KMT2C RBBP5 BCL7C TRPS1 BCL9 SMAD2	5.33e-05	194	69	6	int:MYOD1
Interaction	GATA2 interactions	KMT2C RBBP5 BCL7C TRPS1 POU2AF1 BCL9	6.14e-05	199	69	6	int:GATA2
Interaction	UBE2V1 interactions	RC3H1 DAZAP2 SHISA4 RPA1 RNF11	6.67e-05	124	69	5	int:UBE2V1
Interaction	KMT2C interactions	KMT2C RBBP5 KLF4 RPA1 SMAD2	9.63e-05	134	69	5	int:KMT2C
Interaction	TOP3B interactions	TPST2 KMT2C ERBB2 C2CD3 MYO1E ZNF341 ANXA11 PKD1 ADGRB2 PAPLN BCL9 KLF4 WNK1 SPEN RPA1	1.09e-04	1470	69	15	int:TOP3B
Interaction	RUNX1 interactions	VPS37C RBBP5 PKD1 DAZAP2 SPEN RPA1 SMAD2	1.20e-04	324	69	7	int:RUNX1
Interaction	VPS37C interactions	VPS37C POU2AF1 DAZAP2 TFG PLSCR1	1.22e-04	141	69	5	int:VPS37C
Interaction	NFIX interactions	KMT2C IRF2BP1 RBBP5 BCL7C TRPS1 SPEN	1.27e-04	227	69	6	int:NFIX
Interaction	RAMAC interactions	VPS37C POU2AF1 DAZAP2 PLSCR1	1.80e-04	82	69	4	int:RAMAC
Interaction	GSC interactions	KMT2C TRPS1 BCL9 SMAD2	2.26e-04	87	69	4	int:GSC
GeneFamily	ESCRT-I	VPS37C VPS37A	2.77e-04	9	51	2	1116
GeneFamily	Wiskott-Aldrich Syndrome protein family	WASF2 WASF3	9.13e-04	16	51	2	14
GeneFamily	Zinc fingers C2H2-type\|Kruppel like factors	KLF17 KLF4	1.16e-03	18	51	2	624
Coexpression	GSE42021_TREG_PLN_VS_CD24LO_TREG_THYMUS_DN	MYO1E DROSHA TFG PLSCR1 CRH APBB1IP	1.47e-05	197	70	6	M9580
Coexpression	GSE339_EX_VIVO_VS_IN_CULTURE_CD4POS_DC_DN	HOXA4 TPST2 ANXA11 WNK1 PLSCR1 RNF11	1.60e-05	200	70	6	M5130
Coexpression	GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_DN	VPS37C MYO1E WASF2 AHCTF1 SLC35F6 RNF11	1.60e-05	200	70	6	M7080
Disease	visceral adipose tissue measurement	MAGI2 SEC16B NAALAD2 TRPS1 PKD1 ADGRB2 ALCAM WNK1	1.83e-05	481	70	8	EFO_0004765
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	MAGI2 SEC16B TRPS1 ALCAM MMP15 RPA1	2.28e-04	364	70	6	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	leukemia (implicated_via_orthology)	HOXA4 HOXD4	9.24e-04	19	70	2	DOID:1240 (implicated_via_orthology)
Disease	body fat percentage	MAGI2 SEC16B TRPS1 ALCAM MMP15 RPA1	1.06e-03	488	70	6	EFO_0007800
Disease	West Syndrome	MAGI2 CRH	1.48e-03	24	70	2	C0037769
Disease	Intrahepatic Cholangiocarcinoma	KMT2C ERBB2	1.48e-03	24	70	2	C0345905
Disease	stomach carcinoma (is_marker_for)	KMT2C ERBB2	1.48e-03	24	70	2	DOID:5517 (is_marker_for)
Disease	Extrahepatic Cholangiocarcinoma	KMT2C ERBB2	1.48e-03	24	70	2	C3805278
Disease	myeloperoxidase measurement	SMG8 HSH2D	1.74e-03	26	70	2	EFO_0005243
Disease	Cholangiocarcinoma	KMT2C ERBB2	1.74e-03	26	70	2	C0206698

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLGEPPPPQEANPVY	ADGRB2	1311	O60241
QPEYVNQPDVRPQPP	ERBB2	1136	P04626
QGVYNQPPPQPFPGD	CHRND	491	Q07001
TYPGQPPVPLPGQQQ	ANXA11	151	P50995
PPQQFQAQSSYPPGP	BEND4	76	Q6ZU67
LPPPDPNPPRAEFNY	APBB1IP	31	Q7Z5R6
PRGAAPPFEPAPYQQ	RC3H1	596	Q5TC82
GNPFIQPDSPAPNPF	RBSN	676	Q9H1K0
QQPGTLGYPQPPPAQ	NPAS2	786	Q99743
NFQPPPQPPSEEQFG	CD6	631	P30203
QPPGNPVYPQTLHLP	DAZAP2	16	Q15038
PELDPVYIPPQQPQP	KLF4	206	O43474
ENVNQAFTRPPPPYP	KMT2C	2426	Q8NEZ4
PPQSPAYEPNLFDGP	NFKBIZ	316	Q9BYH8
QSPFPPNPYGQPQVF	GRINA	106	Q7Z429
PNPYGQPQVFPGQDP	GRINA	111	Q7Z429
LDYRQPPGGDYQQPP	MAGI2	1096	Q86UL8
PPGGDYQQPPPLDYR	MAGI2	1101	Q86UL8
QLYGTPDGQPQPTQP	MMP15	301	P51511
QDINDNPPIFPLGPY	CDH24	141	Q86UP0
PGPAGFPVPNQPVYN	PLSCR1	56	O15162
LFPPLPQDTPFFPGQ	PCED1A	336	Q9H1Q7
PPVPPQYQVPGNLSA	MED25	266	Q71SY5
PPPPQGFKQEYHDPL	ETV5	256	P41161
PQPLDFFQPPPQSEQ	CRH	41	P06850
QLPEEYQQPPPFAPG	HSH2D	336	Q96JZ2
PEENPYGPPPDAVQT	RBBP5	411	Q15291
PPDPQAFQGPAAYQP	PASD1	736	Q8IV76
FQPPGLYPRPDFGEQ	HOXD4	46	P09016
LQYQPPAPALPGPQF	POU2AF1	191	Q16633
VPYNEGLGQPQVAPP	RPA1	116	P27694
YPVFEPVPPVPEAAQ	BCL7C	181	Q8WUZ0
PGPIVVPNFFLPPQQ	C2CD3	2271	Q4AC94
GFPQGFPPVQSPPQQ	BCL9	1136	O00512
FPPLPENQPLEGTFP	KL	506	Q9UEF7
QEGPFLPEQPGPAPQ	KLF17	246	Q5JT82
NRGVPPSYPPPEQFF	AHCTF1	456	Q8WYP5
PVYIVQDGPPQSPPN	EFNB3	321	Q15768
GNSTPNPQVPDYPPN	SNRPB2	136	P08579
PPPEEFLFYLPGQPE	ALCAM	276	Q13740
GYQQPPAPPTQHLPL	HOXA4	41	Q00056
PAEALPQQYPEPAPA	IRF2BP1	346	Q8IU81
EPRGPPNPNVEYIPF	PPP4R2	66	Q9NY27
QFQPPYNESFPVPDP	PKD1	1066	P98161
QAPPQPPAPLQDYGG	PRR14L	1791	Q5THK1
EPDQEPPPPYQEQVP	RNF11	31	Q9Y3C5
QVQPGPPPCPVFYPE	SMG8	926	Q8ND04
QPPVQYQYEPPSAPS	DROSHA	46	Q9NRR4
PYYPQPENPDSGGNI	XG	51	P55808
GPPQPQQLAPDFPLA	RNF165	41	Q6ZSG1
PVQPVYPYPQDPKAG	SHISA4	136	Q96DD7
EFPGPAFPRPEPQQG	RNF216	211	Q9NWF9
QPGQLAPPTEYPVPE	TMEM61	46	Q8N0U2
QFLLPYFPPEGPGPE	PRR22	141	Q8IZ63
DPYANPPNYGNPDPF	TPST2	326	O60704
VPGLPNPCQNYVPYP	TRPS1	1131	Q9UHF7
QPYPPLEVPNQCVEP	ZNF341	241	Q9BYN7
ENFPAPPPYPGESQT	SPEN	2231	Q96T58
LGPAPSLQQPPYQQP	PAPLN	606	O95428
AAHPPGVQPQQPPYT	TFG	216	Q92734
EPQSNYIPETPPPGY	SMAD2	211	Q15796
LQPVPPFGVPDFPQQ	SYCP2L	481	Q5T4T6
FQPFLPPPGQELGEP	SELENON	206	Q9NZV5
PAQIIEYYNPSGPPP	WASF3	331	Q9UPY6
DPQQPFNPLLFLPPA	SLC35F6	81	Q8N357
SPQQPFPLQPGSYPA	SEC16B	771	Q96JE7
NLPPPPAEFSYPVDN	WASF2	266	Q9Y6W5
FPPRLPPQYPGDSNI	WNK1	946	Q9H4A3
YPIQPQLPSFPGQPQ	VPS37C	311	A5D8V6
ASQGFPFLPPYPPQE	VPS37A	151	Q8NEZ2
NFPEPPYPDQIICPD	VMP1	156	Q96GC9
PPPDGYENVTNIVPP	NAALAD2	136	Q9Y3Q0
QNANYPVRAAPPPPG	MYO1E	946	Q12965