Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ALOXE3 ALOX12B	9.86e-05	25	12	2	GO:0016702
GeneOntologyMolecularFunction	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	ALOXE3 ALOX12B	1.07e-04	26	12	2	GO:0016701
GeneOntologyMolecularFunction	cholesterol binding	OSBPL6 TSPO	5.37e-04	58	12	2	GO:0015485
GeneOntologyMolecularFunction	sterol binding	OSBPL6 TSPO	8.04e-04	71	12	2	GO:0032934
GeneOntologyMolecularFunction	dioxygenase activity	ALOXE3 ALOX12B	1.52e-03	98	12	2	GO:0051213
GeneOntologyMolecularFunction	alcohol binding	OSBPL6 TSPO	1.65e-03	102	12	2	GO:0043178
GeneOntologyMolecularFunction	hormone binding	TSPO PDE3A	1.68e-03	103	12	2	GO:0042562
GeneOntologyMolecularFunction	steroid binding	OSBPL6 TSPO	2.78e-03	133	12	2	GO:0005496
GeneOntologyMolecularFunction	iron ion binding	ALOXE3 ALOX12B	4.29e-03	166	12	2	GO:0005506
GeneOntologyMolecularFunction	transmembrane transporter binding	TSPO KCND3	4.60e-03	172	12	2	GO:0044325
GeneOntologyMolecularFunction	isomerase activity	ALOXE3 ALOX12B	5.70e-03	192	12	2	GO:0016853
GeneOntologyMolecularFunction	lyase activity	ALOXE3 ALOX12B	6.90e-03	212	12	2	GO:0016829
GeneOntologyBiologicalProcess	hepoxilin metabolic process	ALOXE3 ALOX12B	7.23e-06	8	11	2	GO:0051121
GeneOntologyBiologicalProcess	hepoxilin biosynthetic process	ALOXE3 ALOX12B	7.23e-06	8	11	2	GO:0051122
GeneOntologyBiologicalProcess	lipoxygenase pathway	ALOXE3 ALOX12B	1.42e-05	11	11	2	GO:0019372
GeneOntologyBiologicalProcess	linoleic acid metabolic process	ALOXE3 ALOX12B	6.50e-05	23	11	2	GO:0043651
GeneOntologyBiologicalProcess	long-chain fatty acid biosynthetic process	ALOXE3 ALOX12B	1.04e-04	29	11	2	GO:0042759
GeneOntologyBiologicalProcess	establishment of skin barrier	ALOXE3 ALOX12B	2.10e-04	41	11	2	GO:0061436
GeneOntologyBiologicalProcess	monocarboxylic acid biosynthetic process	ALOXE3 OSBPL6 ALOX12B	3.03e-04	260	11	3	GO:0072330
GeneOntologyBiologicalProcess	arachidonate metabolic process	ALOXE3 ALOX12B	5.78e-04	68	11	2	GO:0019369
GeneOntologyBiologicalProcess	lipid biosynthetic process	ALOXE3 OSBPL6 ALOX12B TSPO	6.33e-04	813	11	4	GO:0008610
GeneOntologyBiologicalProcess	ceramide biosynthetic process	ALOXE3 ALOX12B	6.66e-04	73	11	2	GO:0046513
GeneOntologyBiologicalProcess	bicellular tight junction assembly	ALOXE3 ALOX12B	8.19e-04	81	11	2	GO:0070830
GeneOntologyBiologicalProcess	regulation of cholesterol transport	OSBPL6 TSPO	8.59e-04	83	11	2	GO:0032374
GeneOntologyBiologicalProcess	regulation of sterol transport	OSBPL6 TSPO	8.59e-04	83	11	2	GO:0032371
GeneOntologyBiologicalProcess	carboxylic acid biosynthetic process	ALOXE3 OSBPL6 ALOX12B	8.76e-04	374	11	3	GO:0046394
GeneOntologyBiologicalProcess	organic acid biosynthetic process	ALOXE3 OSBPL6 ALOX12B	8.96e-04	377	11	3	GO:0016053
GeneOntologyBiologicalProcess	tight junction assembly	ALOXE3 ALOX12B	9.65e-04	88	11	2	GO:0120192
GeneOntologyBiologicalProcess	apical junction assembly	ALOXE3 ALOX12B	1.01e-03	90	11	2	GO:0043297
GeneOntologyBiologicalProcess	tight junction organization	ALOXE3 ALOX12B	1.10e-03	94	11	2	GO:0120193
GeneOntologyBiologicalProcess	ceramide metabolic process	ALOXE3 ALOX12B	1.58e-03	113	11	2	GO:0006672
GeneOntologyBiologicalProcess	sphingolipid biosynthetic process	ALOXE3 ALOX12B	1.70e-03	117	11	2	GO:0030148
GeneOntologyBiologicalProcess	long-chain fatty acid metabolic process	ALOXE3 ALOX12B	1.90e-03	124	11	2	GO:0001676
GeneOntologyBiologicalProcess	unsaturated fatty acid metabolic process	ALOXE3 ALOX12B	2.03e-03	128	11	2	GO:0033559
GeneOntologyBiologicalProcess	lipid oxidation	ALOXE3 ALOX12B	2.06e-03	129	11	2	GO:0034440
GeneOntologyBiologicalProcess	cholesterol transport	OSBPL6 TSPO	2.22e-03	134	11	2	GO:0030301
GeneOntologyBiologicalProcess	sterol transport	OSBPL6 TSPO	2.38e-03	139	11	2	GO:0015918
GeneOntologyBiologicalProcess	icosanoid metabolic process	ALOXE3 ALOX12B	2.49e-03	142	11	2	GO:0006690
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	ALOXE3 ALOX12B	3.03e-03	157	11	2	GO:0046467
GeneOntologyBiologicalProcess	skin epidermis development	ALOXE3 ALOX12B	3.38e-03	166	11	2	GO:0098773
GeneOntologyBiologicalProcess	cell-cell junction assembly	ALOXE3 ALOX12B	3.42e-03	167	11	2	GO:0007043
GeneOntologyBiologicalProcess	amide biosynthetic process	ALOXE3 ALOX12B	3.62e-03	172	11	2	GO:0043604
GeneOntologyBiologicalProcess	sphingolipid metabolic process	ALOXE3 ALOX12B	3.79e-03	176	11	2	GO:0006665
GeneOntologyBiologicalProcess	regulation of lipid transport	OSBPL6 TSPO	3.91e-03	179	11	2	GO:0032368
GeneOntologyBiologicalProcess	olefinic compound metabolic process	ALOXE3 ALOX12B	3.96e-03	180	11	2	GO:0120254
GeneOntologyBiologicalProcess	regulation of organelle organization	TSPO PDE3A MAGEL2 NAF1	4.07e-03	1342	11	4	GO:0033043
GeneOntologyBiologicalProcess	fatty acid biosynthetic process	ALOXE3 ALOX12B	4.44e-03	191	11	2	GO:0006633
GeneOntologyBiologicalProcess	small molecule biosynthetic process	ALOXE3 OSBPL6 ALOX12B	4.75e-03	676	11	3	GO:0044283
GeneOntologyBiologicalProcess	steroid biosynthetic process	OSBPL6 TSPO	5.29e-03	209	11	2	GO:0006694
GeneOntologyBiologicalProcess	lipid modification	ALOXE3 ALOX12B	5.54e-03	214	11	2	GO:0030258
GeneOntologyBiologicalProcess	regulation of lipid localization	OSBPL6 TSPO	5.59e-03	215	11	2	GO:1905952
GeneOntologyBiologicalProcess	RNA localization	NAF1 MX2	5.69e-03	217	11	2	GO:0006403
GeneOntologyCellularComponent	perinuclear endoplasmic reticulum	OSBPL6 KCND3	1.22e-04	29	12	2	GO:0097038
HumanPheno	Intellectual disability, borderline	ALOXE3 ALOX12B MAGEL2	3.61e-06	25	7	3	HP:0006889
HumanPheno	Palmar hyperlinearity	ALOXE3 ALOX12B	3.39e-05	7	7	2	HP:0033252
HumanPheno	Thin nail	ALOXE3 ALOX12B	1.92e-04	16	7	2	HP:0001816
Domain	LIPOXYGENASE_1	ALOXE3 ALOX12B	5.67e-06	6	12	2	PS00711
Domain	LipOase_C	ALOXE3 ALOX12B	5.67e-06	6	12	2	IPR013819
Domain	LIPOXYGENASE_2	ALOXE3 ALOX12B	5.67e-06	6	12	2	PS00081
Domain	LipOase	ALOXE3 ALOX12B	5.67e-06	6	12	2	IPR000907
Domain	Lipoxygenase	ALOXE3 ALOX12B	5.67e-06	6	12	2	PF00305
Domain	LIPOXYGENASE_3	ALOXE3 ALOX12B	5.67e-06	6	12	2	PS51393
Domain	LipOase_Fe_BS	ALOXE3 ALOX12B	5.67e-06	6	12	2	IPR020833
Domain	LipOase_CS	ALOXE3 ALOX12B	5.67e-06	6	12	2	IPR020834
Domain	LipOase_mml	ALOXE3 ALOX12B	5.67e-06	6	12	2	IPR001885
Domain	LH2	ALOXE3 ALOX12B	5.76e-05	18	12	2	SM00308
Domain	PLAT	ALOXE3 ALOX12B	7.89e-05	21	12	2	PS50095
Domain	PLAT/LH2_dom	ALOXE3 ALOX12B	7.89e-05	21	12	2	IPR001024
Domain	-	ALOXE3 ALOX12B	7.89e-05	21	12	2	2.60.60.20
Domain	PLAT	ALOXE3 ALOX12B	7.89e-05	21	12	2	PF01477
Pathway	REACTOME_SYNTHESIS_OF_12_EICOSATETRAENOIC_ACID_DERIVATIVES	ALOXE3 ALOX12B	1.16e-05	7	11	2	M27139
Pathway	REACTOME_SYNTHESIS_OF_12_EICOSATETRAENOIC_ACID_DERIVATIVES	ALOXE3 ALOX12B	1.16e-05	7	11	2	MM14860
Pathway	WP_OCTADECANOID_FORMATION_FROM_LINOLEIC_ACID	ALOXE3 ALOX12B	3.64e-05	12	11	2	M48064
Pathway	WP_NOCGMPPKG_MEDIATED_NEUROPROTECTION	TSPO PDE3A	5.87e-04	47	11	2	M39531
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	ALOXE3 ALOX12B	9.24e-04	59	11	2	M27140
Pathway	REACTOME_METABOLISM_OF_LIPIDS	ALOXE3 OSBPL6 ALOX12B TSPO	9.55e-04	620	11	4	MM15193
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	ALOXE3 ALOX12B	9.88e-04	61	11	2	MM14861
Pathway	REACTOME_METABOLISM_OF_LIPIDS	ALOXE3 OSBPL6 ALOX12B TSPO	2.01e-03	757	11	4	M27451
Pathway	WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES	OSBPL6 TSPO	3.23e-03	111	11	2	M48065
Pathway	REACTOME_METABOLISM_OF_STEROIDS	OSBPL6 TSPO	4.14e-03	126	11	2	MM15553
Pathway	REACTOME_METABOLISM_OF_STEROIDS	OSBPL6 TSPO	6.11e-03	154	11	2	M27832
Pathway	REACTOME_FATTY_ACID_METABOLISM	ALOXE3 ALOX12B	7.40e-03	170	11	2	MM15573
Pathway	REACTOME_FATTY_ACID_METABOLISM	ALOXE3 ALOX12B	7.92e-03	176	11	2	M27854
Pubmed	12R-lipoxygenase deficiency disrupts epidermal barrier function.	ALOXE3 ALOX12B	1.09e-07	2	12	2	17403930
Pubmed	Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.	ALOXE3 ALOX12B	1.09e-07	2	12	2	11773004
Pubmed	Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.	ALOXE3 ALOX12B	1.09e-07	2	12	2	15629692
Pubmed	Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope.	ALOXE3 ALOX12B	1.09e-07	2	12	2	21558561
Pubmed	Meta-Analysis of Mutations in ALOX12B or ALOXE3 Identified in a Large Cohort of 224 Patients.	ALOXE3 ALOX12B	1.09e-07	2	12	2	33435499
Pubmed	Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B.	ALOXE3 ALOX12B	1.09e-07	2	12	2	19131948
Pubmed	The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier.	ALOXE3 ALOX12B	1.09e-07	2	12	2	24021977
Pubmed	Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.	ALOXE3 ALOX12B	3.27e-07	3	12	2	17139268
Pubmed	Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation.	ALOXE3 ALOX12B	3.27e-07	3	12	2	22832496
Pubmed	cDNA cloning, genomic structure, and chromosomal localization of a novel murine epidermis-type lipoxygenase.	ALOXE3 ALOX12B	3.27e-07	3	12	2	10366447
Pubmed	Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients.	ALOXE3 ALOX12B	3.27e-07	3	12	2	19890349
Pubmed	The role of lipoxygenases in epidermis.	ALOXE3 ALOX12B	3.27e-07	3	12	2	23954555
Pubmed	A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression.	ALOXE3 ALOX12B	6.55e-07	4	12	2	11350124
Pubmed	The expression of epidermal lipoxygenases and transglutaminase-1 is perturbed by NIPAL4 mutations: indications of a common metabolic pathway essential for skin barrier homeostasis.	ALOXE3 ALOX12B	6.55e-07	4	12	2	22622417
Pubmed	Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha.	ALOXE3 ALOX12B	1.09e-06	5	12	2	17436029
Pubmed	Autosomal Recessive Congenital Ichthyosis	ALOXE3 ALOX12B	8.49e-06	13	12	2	20301593
Pubmed	PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier.	ALOXE3 ALOX12B	1.86e-05	19	12	2	28369476
Pubmed	Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation.	ALOXE3 ALOX12B	3.26e-05	25	12	2	19092943
Interaction	CCDC27 interactions	ALOXE3 ALOX12B	3.40e-05	15	12	2	int:CCDC27
Interaction	ZNF154 interactions	ALOXE3 ALOX12B	1.22e-04	28	12	2	int:ZNF154
Interaction	B3GALNT1 interactions	ALOXE3 ALOX12B	1.40e-04	30	12	2	int:B3GALNT1
Interaction	SFR1 interactions	ALOXE3 ALOX12B	2.14e-04	37	12	2	int:SFR1
Interaction	IFNA4 interactions	ALOXE3 ALOX12B	2.63e-04	41	12	2	int:IFNA4
Interaction	GALNT9 interactions	ALOXE3 ALOX12B	3.17e-04	45	12	2	int:GALNT9
Cytoband	17p13.1	ALOXE3 ALOX12B	4.25e-04	118	12	2	17p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2q31	OSBPL6 HOXD8	9.62e-04	178	12	2	chr2q31
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	ALOXE3 ALOX12B	3.56e-03	346	12	2	chr17p13
GeneFamily	Arachidonate lipoxygenases	ALOXE3 ALOX12B	2.57e-06	6	8	2	407
Coexpression	MIKKELSEN_ES_HCP_WITH_H3K27ME3	ALOX12B HOXD8 KCND3	7.74e-07	41	12	3	M2000
Coexpression	MIKKELSEN_ES_HCP_WITH_H3K27ME3	ALOX12B HOXD8 KCND3	8.33e-07	42	12	3	MM1275
Coexpression	GSE28737_WT_VS_BCL6_KO_MARGINAL_ZONE_BCELL_UP	TSPO PDE3A PADI1 MX2	1.52e-06	199	12	4	M9345
Coexpression	TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP	OSBPL6 PDE3A MX2	7.03e-05	183	12	3	M6670
Coexpression	GSE369_PRE_VS_POST_IL6_INJECTION_IFNG_KO_LIVER_DN	OSBPL6 HOXD8 MX2	9.15e-05	200	12	3	M5975
Coexpression	GSE34156_NOD2_LIGAND_VS_TLR1_TLR2_LIGAND_6H_TREATED_MONOCYTE_UP	MAGEL2 KCND3 MX2	9.15e-05	200	12	3	M8690
Coexpression	GSE9650_GP33_VS_GP276_LCMV_SPECIFIC_EXHAUSTED_CD8_TCELL_UP	ALOXE3 MAGEL2 PADI1	9.15e-05	200	12	3	M5842
ToppCell	COVID-19-Heart-CM_4\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OSBPL6 PDE3A KCND3	1.42e-05	183	12	3	2902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Efna5_(Deep_layer_pyramidal_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ALOX12B PADI1	9.26e-05	54	12	2	13431c23a110070a11de41773233a8d6583d902c
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Efna5_(Deep_layer_pyramidal_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ALOX12B PADI1	9.26e-05	54	12	2	cd64ee5c47df5dba0cea954cb115a8de0efb55d1
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Pdyn_(Striatum,_patch_dSPNs)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ALOX12B HOXD8	9.61e-05	55	12	2	21a72cc6f12889509dbfaa9929be48d00f5f6345
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Pdyn_(Striatum,_patch_dSPNs)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ALOX12B HOXD8	9.61e-05	55	12	2	6575ee5274f1044e17f4a5204375acc82ef16182
ToppCell	Entopeduncular-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Excitatory_Neuron.Slc17a6.Pitx2_(Subthalamic_Nucleus_(STN),_maybe_ENT_as_well)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ALOX12B PADI1	1.30e-04	64	12	2	ce0c117d29057640f2be09c3a4cde7733bf2f5ac
ToppCell	Entopeduncular-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ALOX12B PADI1	1.30e-04	64	12	2	5bfbacbd39dd176a29703e2a99644b465a50c655
ToppCell	Entopeduncular-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ALOX12B PADI1	1.30e-04	64	12	2	f56966e8f54db8f973533166e0ae4dd829a390c9
ToppCell	Entopeduncular-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Excitatory_Neuron.Slc17a6.Pitx2_(Subthalamic_Nucleus_(STN),_maybe_ENT_as_well)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ALOX12B PADI1	1.30e-04	64	12	2	77fcb80a2c56aef754dd5eb327a39c698766ebcf
ToppCell	droplet-Large_Intestine-COLON_-_"PROM_Tm"-30m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALOXE3 HOXD8	2.81e-04	94	12	2	2fb80a08f823295fa4c3e6494bf020e5b4052f0f
ToppCell	droplet-Large_Intestine-COLON_-_"PROM_Tm"-30m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALOXE3 HOXD8	2.81e-04	94	12	2	d25f096626af873f724a8cd6454ed56e33fd9854
ToppCell	primary_visual_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Cytl1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	HOXD8 TSPO	5.12e-04	127	12	2	eee8e4a83f7de46807440d202d46eee7dd722001
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ALOX12B HSFY1	5.53e-04	132	12	2	182973660929fe4174e0354c85863a25518c18c1
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE3A PADI1	5.87e-04	136	12	2	88b5c839d0446c6d6b7e81fc4d48f5e7e96eea11
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PDE3A PADI1	5.87e-04	136	12	2	27a41463e6f16deb5b1d4f17fefded9959038c07
ToppCell	facs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI1 MX2	6.31e-04	141	12	2	4aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCell	facs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI1 MX2	6.31e-04	141	12	2	e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCell	facs-Heart-Unknown-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI1 MX2	6.39e-04	142	12	2	759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCell	E16.5-samps-Mesenchymal-Pericyte-pericyte_A\|E16.5-samps / Age Group, Lineage, Cell class and subclass	PDE3A MAGEL2	6.94e-04	148	12	2	c87fe2373418ec0cfe37279003d1c4df4c0d0aac
ToppCell	E16.5-samps-Mesenchymal-Pericyte\|E16.5-samps / Age Group, Lineage, Cell class and subclass	PDE3A MAGEL2	6.94e-04	148	12	2	e697a7fb037873c9b11703d1bf836a69fc276e23
ToppCell	ileum-BEST4+_Enterocytes\|ileum / shred on tissue and cell subclass	TSPO PDE3A	7.51e-04	154	12	2	608e9c982125e0c2c15b86b1920813845a0db81f
ToppCell	COVID-19-Mast_cells-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	OSBPL6 PDE3A	7.71e-04	156	12	2	bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	ALOX12B KCND3	7.71e-04	156	12	2	ffb9249a115ce31f50b99a7a3d40bf48b9d7f2b0
ToppCell	COVID-19-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	OSBPL6 PDE3A	7.71e-04	156	12	2	159504d43421ee83b9ab484816333ae549c9c2fd
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_OPC-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ALOXE3 HOXD8	7.71e-04	156	12	2	27590a4d2b419644966f0037c67c761fc275e0aa
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TSPO PDE3A	7.90e-04	158	12	2	08806240228c5b780f5aef92ce2c278ae4d797cc
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell-SMC-SMC_Acta2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TSPO PDE3A	7.90e-04	158	12	2	496b6988f7b3439968351840ae22f56ffa1643f1
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell-SMC\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TSPO PDE3A	7.90e-04	158	12	2	5b3d30f92b619f14a7b48502170000fa5783358a
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	OSBPL6 PDE3A	8.00e-04	159	12	2	7b6370c9567da7d40541c6e243efa704ed7e90ae
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic-mast_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	OSBPL6 PDE3A	8.00e-04	159	12	2	ecd1daa33549541aee3bf4e139ab6732efc8e74c
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI1 MX2	8.20e-04	161	12	2	ed93cb6c133855a5c244821e1a260aae8ab4df9a
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI1 MX2	8.20e-04	161	12	2	0089d7bb305c592392791862a3341fc92af8f3e2
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	OSBPL6 PDE3A	8.41e-04	163	12	2	51dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCell	E18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_B\|E18.5-samps / Age Group, Lineage, Cell class and subclass	ALOXE3 MX2	8.41e-04	163	12	2	d6f9b7280c44d120df5a72dfc2ebb26ffbb5752b
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALOXE3 NAF1	8.41e-04	163	12	2	953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell-SMC\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TSPO PDE3A	8.51e-04	164	12	2	9eed945e9b0c1ee5fc62724ac2bbbed4267b0678
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell-SMC-SMC_Acta2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TSPO PDE3A	8.51e-04	164	12	2	f510f20e37e31b486cdd0e3f597ce4ff00877c5d
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TSPO PDE3A	8.51e-04	164	12	2	5c932a462cbf81d029c8d11ec3aea3191529527b
ToppCell	LPS_only-Epithelial_airway-Club_cells-Airway\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ALOX12B PADI1	8.51e-04	164	12	2	b1243b10591e1e15a94952e39ffbf382eae6aae8
ToppCell	LPS_only-Epithelial_airway\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ALOX12B PADI1	8.51e-04	164	12	2	56e6934e6c7503a300d7be06762d45a1d6f1ae0f
ToppCell	LPS_only-Epithelial_airway-Club_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ALOX12B PADI1	8.51e-04	164	12	2	c5b2001280a43da855017361a3f6071a0e492848
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HOXD8 TSPO	8.61e-04	165	12	2	50f1fa7434ebb777e15d5273d1ff41070cff6db3
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TSPO NAF1	8.61e-04	165	12	2	8a278e72a9a779152de78b6bd55567d82941c5aa
ToppCell	TCGA-Head_and_Esophagus\|World / Sample_Type by Project: Shred V9	ALOXE3 ALOX12B	9.35e-04	172	12	2	eb18aa179db1818f408c38e442ecfed8582d7dbc
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3-6_VIP_KCTD13\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE3A MAGEL2	9.46e-04	173	12	2	90e3b9ea3d5f565cfc669e33c4d805b2940a09b3
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HOXD8 TSPO	9.46e-04	173	12	2	a8ee017938dd4705361e6fd9a17061ab927027f4
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HOXD8 TSPO	9.46e-04	173	12	2	c1e443c611e6f88ccbba6c019895437aa986414b
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial-club_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OSBPL6 PADI1	9.57e-04	174	12	2	46838b4bb9b4d8ce5e1c608a700e7f393bc52658
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial-club_cell-club_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OSBPL6 PADI1	9.57e-04	174	12	2	103594eeb600eb5bc9cbf09a65b286b3a3a18cdc
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Smooth_muscle_cells\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	PDE3A KCND3	9.68e-04	175	12	2	fed9e4120c758fdcc23bb248d1801002b0e0d485
ToppCell	droplet-Spleen-nan-3m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI1 MX2	9.68e-04	175	12	2	21bc0e59a9509d38751ce6aad2325f341bc70eff
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_Erythro-Mega-Megakaryocyte_early\|lymph-node_spleen / Manually curated celltypes from each tissue	PDE3A KCND3	9.79e-04	176	12	2	50fe3fd862dd6a6550ebb8c27f337cde468efedc
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-nan\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXD8 TSPO	1.00e-03	178	12	2	0f85602f652235b19d208e837896f32081052d3d
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TSPO MX2	1.01e-03	179	12	2	3d3716078afdb9a89ddfadb3197cd1b52fa770be
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-Microfold_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ALOX12B TSPO	1.01e-03	179	12	2	c7d7a66fca6a41de0af3cc2b75a29a54456842cd
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-suprabasal_interpapillary\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALOXE3 ALOX12B	1.02e-03	180	12	2	18bf8561ad3aa9787d2a8ef942a96f641734c608
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OSBPL6 HOXD8	1.06e-03	183	12	2	2d0d3b486498a7903fa9a1f48b189291da49c430
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_prolif-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TSPO MAGEL2	1.07e-03	184	12	2	65b00145cb7da7d64eb6765569573c1a902a1036
ToppCell	IPF-Myeloid-Mast\|Myeloid / Disease state, Lineage and Cell class	OSBPL6 PDE3A	1.07e-03	184	12	2	7326a16d7d3ae41b8c9d2beaec7f977b374f3469
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A KCND3	1.07e-03	184	12	2	e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell	IPF-Myeloid-Mast\|World / Disease state, Lineage and Cell class	OSBPL6 PDE3A	1.07e-03	184	12	2	7aefa182acad5a53c730945fec85329d7168606a
ToppCell	367C-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PDE3A MX2	1.08e-03	185	12	2	b57dae20c21f984edd2acee4344d86f033108ebf
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXD8 TSPO	1.08e-03	185	12	2	241ea1e178fffef9e7df971de739e794332d5173
ToppCell	367C-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PDE3A MX2	1.08e-03	185	12	2	d3b054d203e575c1bb5455aa7a2e551a0957a760
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TSPO MX2	1.09e-03	186	12	2	e4de270d38bbed022f545bd0bbaa9599e707ec87
ToppCell	droplet-Tongue-nan-24m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALOX12B PADI1	1.09e-03	186	12	2	18c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCell	COPD-Myeloid-Mast\|COPD / Disease state, Lineage and Cell class	OSBPL6 PDE3A	1.09e-03	186	12	2	def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TSPO KCND3	1.10e-03	187	12	2	3912bbb610a4a84791e9bda92a2d57a52c31d29e
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma-6\|TCGA-Skin / Sample_Type by Project: Shred V9	ALOXE3 ALOX12B	1.10e-03	187	12	2	2ca7928baf0c5e61f7294ed05e6e6f0e0adf9d3f
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	OSBPL6 PDE3A	1.10e-03	187	12	2	fa01a61bfd13feb033ba1e35cf513707b1bff8c8
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	OSBPL6 PDE3A	1.12e-03	188	12	2	ccddc08121caff958a2b6f9e278a018858af6b4d
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	PDE3A KCND3	1.13e-03	189	12	2	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-classical_monocyte-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TSPO MX2	1.13e-03	189	12	2	cce6602ad68c177985a5e43cfb2776d615cfbca0
ToppCell	TCGA-Skin-Primary_Tumor\|TCGA-Skin / Sample_Type by Project: Shred V9	ALOXE3 ALOX12B	1.14e-03	190	12	2	e2b26a03c6ab24d9b0f4150c47597be37767d86e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A KCND3	1.14e-03	190	12	2	efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	PDE3A KCND3	1.14e-03	190	12	2	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TSPO KCND3	1.14e-03	190	12	2	e102622f05c7f3e1bd8b224ea159d57033793ee0
ToppCell	COVID-19-Heart-CM_4\|Heart / Disease (COVID-19 only), tissue and cell type	OSBPL6 KCND3	1.14e-03	190	12	2	3729648a17093b438398b82e32bbccc3af7b8c5d
ToppCell	COPD-Myeloid-Mast\|Myeloid / Disease state, Lineage and Cell class	OSBPL6 PDE3A	1.14e-03	190	12	2	379dbac19110b76079a7a53209569e060a852acb
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	PDE3A KCND3	1.14e-03	190	12	2	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	ALOXE3 ALOX12B	1.14e-03	190	12	2	3188c7bd225cbcf46a21e2fb784336cdd9665995
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	ALOXE3 ALOX12B	1.14e-03	190	12	2	01fb45add4661bc86cd0a34fac35177907152dbb
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	PDE3A KCND3	1.15e-03	191	12	2	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	OSBPL6 PDE3A	1.16e-03	192	12	2	5000440dc1ed17e7474d340921bdff945646f27e
ToppCell	CV-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	TSPO MX2	1.16e-03	192	12	2	2a2052b44e8f679ef484f03ba4fb37b0ec841b88
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALOX12B PADI1	1.16e-03	192	12	2	c7185fbc56ffd4c62db47fc240b3207ef65db40e
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	OSBPL6 PDE3A	1.16e-03	192	12	2	55f95454399fd533df75db06584eaa48d6ee3830
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HOXD8 PADI1	1.17e-03	193	12	2	264785a88583fd4bbb2ed2e9a7a78bbed539e0ed
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TSPO KCND3	1.17e-03	193	12	2	173f1d83133f5ffa88e2a75d28835ad7acd2aa90
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TSPO KCND3	1.17e-03	193	12	2	b1893193766ae41bf2ab6ed4083285c9c814e608
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Monocytes\|metastatic_Lymph_Node / Location, Cell class and cell subclass	TSPO NAF1	1.17e-03	193	12	2	e67e960a5312ed73c5169795cb282e431866b9c1
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALOX12B PADI1	1.17e-03	193	12	2	55eab7d2574e9cc2ed8f08e0a7ca7cbf90fb5818
ToppCell	Monocytes-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	TSPO MX2	1.19e-03	194	12	2	ed14fbb3b4622798f8e02dc91bbe464a6fed8310
ToppCell	11.5-Distal-Mesenchymal-Pericyte\|Distal / Age, Tissue, Lineage and Cell class	OSBPL6 PDE3A	1.19e-03	194	12	2	08701590496cf85ff790e54a81493c61177e76ff
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TSPO KCND3	1.19e-03	194	12	2	bea369e9a7018d862e4d7f1c9ec2de50f3fd38ec
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A KCND3	1.19e-03	194	12	2	c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	PDE3A KCND3	1.20e-03	195	12	2	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	facs-Lung-nan-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXD8 PDE3A	1.20e-03	195	12	2	7f9b7f15006610ad591063d90e90367bd6083c7f
ToppCell	metastatic_Brain-Myeloid_cells-Monocytes\|metastatic_Brain / Location, Cell class and cell subclass	TSPO NAF1	1.20e-03	195	12	2	dfc24ee09bdc20d8a38feb8a4cc5f6b54a032981
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A KCND3	1.20e-03	195	12	2	3c3703f092b6fc1b7333426fb5e2823bfb74bb57
Drug	ketoprofen	ALOXE3 ALOX12B TSPO	4.58e-06	64	12	3	CID000003825
Drug	12-IODE	ALOXE3 ALOX12B	5.34e-06	7	12	2	CID006450050
Drug	BN 52021	ALOXE3 ALOX12B TSPO	6.81e-06	73	12	3	CID000065243
Drug	colneleic acid	ALOXE3 ALOX12B	7.12e-06	8	12	2	CID006441681
Drug	htyA	ALOXE3 ALOX12B	7.12e-06	8	12	2	CID000152267
Drug	14,15-leukotriene A4	ALOXE3 ALOX12B	9.15e-06	9	12	2	CID006439604
Drug	ODYA	ALOXE3 ALOX12B	9.15e-06	9	12	2	CID000001931
Drug	octadeca-9,12-dien-1-ol	ALOXE3 ALOX12B	9.15e-06	9	12	2	CID000068168
Drug	8,15-diHPETE	ALOXE3 ALOX12B	9.15e-06	9	12	2	CID005283181
Drug	13-hydroxylinoleic acid	ALOXE3 ALOX12B	9.15e-06	9	12	2	CID006438633
Drug	AC1NSXHC	ALOXE3 ALOX12B	9.15e-06	9	12	2	CID005371969
Drug	U-66,855	ALOXE3 ALOX12B	9.15e-06	9	12	2	CID000127235
Drug	AC1L1IMV	ALOXE3 ALOX12B KCND3	1.12e-05	86	12	3	CID000004646
Drug	9-HPODE	ALOXE3 ALOX12B	1.14e-05	10	12	2	CID000001928
Drug	1,4-pentadiene	ALOXE3 ALOX12B	1.14e-05	10	12	2	CID000011587
Drug	acetone phenylhydrazone	ALOXE3 ALOX12B	1.40e-05	11	12	2	CID000066026
Drug	Ity A	ALOXE3 ALOX12B	1.40e-05	11	12	2	CID000188274
Drug	nonenal	ALOXE3 ALOX12B	1.68e-05	12	12	2	CID003015503
Drug	9-HETE	ALOXE3 ALOX12B	1.98e-05	13	12	2	CID000001926
Drug	AC1NR1Q2	ALOXE3 ALOX12B	1.98e-05	13	12	2	CID005283190
Drug	AC1L1BGZ	ALOXE3 ALOX12B	1.98e-05	13	12	2	CID000001435
Drug	ICI207968	ALOXE3 ALOX12B	1.98e-05	13	12	2	CID000129095
Drug	AC1O4E1A	ALOXE3 ALOX12B	1.98e-05	13	12	2	CID006365736
Drug	oxphaman	ALOXE3 ALOX12B	2.31e-05	14	12	2	CID005464022
Drug	AC1NR1LB	ALOXE3 ALOX12B	2.31e-05	14	12	2	CID005283131
Drug	timegadine	ALOXE3 ALOX12B	2.31e-05	14	12	2	CID000068902
Drug	5-HEPE	ALOXE3 ALOX12B	2.31e-05	14	12	2	CID000001766
Drug	17-HdoHE	ALOXE3 ALOX12B	2.31e-05	14	12	2	CID006439179
Drug	8(S),15(S)-diHETE	ALOXE3 ALOX12B	2.66e-05	15	12	2	CID000001897
Drug	8R-HpETE	ALOXE3 ALOX12B	2.66e-05	15	12	2	CID005283170
Drug	Hex-3-enyl acetate	ALOXE3 ALOX12B	2.66e-05	15	12	2	CID000015574
Drug	13-HpOTrE	ALOXE3 ALOX12B	2.66e-05	15	12	2	CID005282866
Drug	eye gene	ALOXE3 ALOX12B PDE3A KCND3	3.03e-05	369	12	4	CID000004782
Drug	hex-3-enal	ALOXE3 ALOX12B	3.04e-05	16	12	2	CID000023234
Drug	AC1NR1M2	ALOXE3 ALOX12B	3.04e-05	16	12	2	CID005283140
Drug	12R-HETrE	ALOXE3 ALOX12B	3.04e-05	16	12	2	CID005283149
Drug	peroxylinolenic acid	ALOXE3 ALOX12B	3.04e-05	16	12	2	CID006439905
Drug	ETYA	ALOXE3 ALOX12B KCND3	3.19e-05	122	12	3	CID000001780
Drug	5,15-diHETE	ALOXE3 ALOX12B	3.45e-05	17	12	2	CID005283158
Drug	cirsiliol	ALOXE3 ALOX12B	3.45e-05	17	12	2	CID000160237
Drug	FPL 57231	ALOXE3 ALOX12B	3.88e-05	18	12	2	CID000122212
Drug	3-nonenal	ALOXE3 ALOX12B	3.88e-05	18	12	2	CID005283336
Drug	BW540C	ALOXE3 ALOX12B	3.88e-05	18	12	2	CID000134372
Drug	AC1O5PL5	ALOXE3 ALOX12B	3.88e-05	18	12	2	CID006438380
Drug	L-651,392	ALOXE3 ALOX12B	4.81e-05	20	12	2	CID000122182
Drug	TMK777	ALOXE3 ALOX12B	4.81e-05	20	12	2	CID006438911
Drug	AC1L2P35	ALOXE3 ALOX12B	4.81e-05	20	12	2	CID000125736
Drug	AC1O5S1P	ALOXE3 ALOX12B	5.32e-05	21	12	2	CID006439617
Drug	AC1NRAUB	ALOXE3 ALOX12B	5.32e-05	21	12	2	CID005288098
Drug	20-carboxyleukotriene B4	ALOXE3 ALOX12B	5.32e-05	21	12	2	CID000001588
Drug	5,8,11-eicosatrienoic acid	ALOXE3 ALOX12B	5.85e-05	22	12	2	CID000004028
Drug	CGS 8515	ALOXE3 ALOX12B	5.85e-05	22	12	2	CID000163944
Drug	diethylcarbamazine	ALOXE3 ALOX12B	5.85e-05	22	12	2	CID000003052
Drug	BM 13.177	ALOXE3 ALOX12B	5.85e-05	22	12	2	CID000051550
Drug	L-656,224	ALOXE3 ALOX12B	6.40e-05	23	12	2	CID000128132
Drug	AC1NSYHD	ALOXE3 ALOX12B	6.40e-05	23	12	2	CID005319705
Drug	octadecadienoic acid	ALOXE3 ALOX12B	6.40e-05	23	12	2	CID005312457
Drug	13-hydroperoxylinoleic acid	ALOXE3 ALOX12B	7.59e-05	25	12	2	CID006438144
Drug	pinolenic acid	ALOXE3 ALOX12B	7.59e-05	25	12	2	CID005312493
Drug	AC1L3X17	ALOXE3 ALOX12B	7.59e-05	25	12	2	CID000123644
Drug	8-HETE	ALOXE3 ALOX12B	8.22e-05	26	12	2	CID000001898
Drug	AC1L3WDO	ALOXE3 ALOX12B	8.22e-05	26	12	2	CID000123344
Drug	lithium dimer	ALOXE3 ALOX12B	8.22e-05	26	12	2	CID000139759
Drug	11-HETE	ALOXE3 ALOX12B	8.22e-05	26	12	2	CID000001406
Drug	20-hydroxyleukotriene B4	ALOXE3 ALOX12B	8.22e-05	26	12	2	CID000001589
Drug	hematoporphyrin	TSPO MX2	8.87e-05	27	12	2	CID000011103
Drug	SC-41930	ALOXE3 ALOX12B	8.87e-05	27	12	2	CID000114999
Drug	Bhpp	ALOXE3 ALOX12B	8.87e-05	27	12	2	CID000164136
Drug	BW A4C	ALOXE3 ALOX12B	8.87e-05	27	12	2	CID006438354
Drug	L-649,923	ALOXE3 ALOX12B	9.55e-05	28	12	2	CID000119331
Drug	AC1L1G9E	ALOXE3 ALOX12B	9.55e-05	28	12	2	CID000003586
Drug	13-epi-12-oxo-phytodienoic acid	ALOXE3 ALOX12B	1.03e-04	29	12	2	CID000188366
Drug	nafazatrom	ALOXE3 ALOX12B	1.03e-04	29	12	2	CID000042923
Drug	1wbv	ALOXE3 ALOX12B	1.10e-04	30	12	2	CID005326870
Drug	12-hydroxyheptadecatrienoic acid	ALOXE3 ALOX12B	1.17e-04	31	12	2	CID000001414
Drug	Gliclazide [21187-98-4]; Up 200; 12.4uM; PC3; HT_HG-U133A	ALOX12B PADI1 KCND3	1.33e-04	197	12	3	5089_UP
Drug	(Z)-7-[(1R,2R,3R)-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dienyl]-3-methyl-5-oxocyclopentyl]hept-5-enoic acid	ALOXE3 ALOX12B	1.33e-04	33	12	2	CID009548573
Drug	U-62066 [87151-85-7]; Up 200; 1uM; PC3; HT_HG-U133A	ALOXE3 ALOX12B KCND3	1.35e-04	198	12	3	4553_UP
Drug	ICI 198,615	ALOXE3 ALOX12B	1.42e-04	34	12	2	CID000115219
Drug	diclofenac	ALOXE3 ALOX12B TSPO	1.58e-04	209	12	3	CID000003032
Drug	tsuwabukinonol	ALOXE3 ALOX12B	1.68e-04	37	12	2	CID006440419
Drug	sIL-4R	ALOXE3 ALOX12B	1.68e-04	37	12	2	CID000059757
Drug	11,14,15-THET	ALOXE3 ALOX12B	1.87e-04	39	12	2	CID006439531
Drug	tricarbon	ALOXE3 ALOX12B	1.87e-04	39	12	2	CID006432003
Drug	REV 5901	ALOXE3 ALOX12B	1.87e-04	39	12	2	CID000005059
Drug	benoxaprofen	ALOXE3 ALOX12B	2.06e-04	41	12	2	CID000039941
Drug	AC1L1H1K	ALOXE3 ALOX12B	2.06e-04	41	12	2	CID000003935
Drug	11,12,15-trihydroxyeicosatrienoic acid	ALOXE3 ALOX12B	2.17e-04	42	12	2	CID006439610
Drug	AC1MRR4N	ALOXE3 ALOX12B	2.27e-04	43	12	2	CID003522488
Drug	12-HPETE	ALOXE3 ALOX12B	2.27e-04	43	12	2	CID000001415
Drug	BAY X 1005	ALOXE3 ALOX12B	2.27e-04	43	12	2	CID000123723
Drug	AC1L1JAX	ALOXE3 ALOX12B	2.38e-04	44	12	2	CID000004958
Drug	amsacrine	TSPO MX2	2.49e-04	45	12	2	CID000002179
Drug	VML 295	ALOXE3 ALOX12B	2.49e-04	45	12	2	CID000177941
Drug	phenidone	ALOXE3 ALOX12B	2.60e-04	46	12	2	CID000007090
Drug	8-isoprostaglandin E1	ALOXE3 ALOX12B PDE3A	2.71e-04	251	12	3	CID000000214
Drug	hexanal	ALOXE3 ALOX12B	2.72e-04	47	12	2	CID000006184
Drug	AC1L1DS5	ALOX12B PDE3A	2.83e-04	48	12	2	CID000002483
Drug	5-ASA	ALOXE3 ALOX12B	3.08e-04	50	12	2	CID000004075
Drug	AC1L1C7C	ALOXE3 ALOX12B	3.08e-04	50	12	2	CID000001772
Disease	ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL, NONBULLOUS, 1	ALOXE3 ALOX12B	1.26e-07	2	11	2	C1855792
Disease	Autosomal recessive congenital ichthyosis 2	ALOXE3 ALOX12B	1.26e-07	2	11	2	cv:C3888093
Disease	ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 2	ALOXE3 ALOX12B	1.26e-07	2	11	2	242100
Disease	Self-Healing Collodion Baby	ALOXE3 ALOX12B	3.79e-07	3	11	2	C1855789
Disease	Ichthyosis Congenita I	ALOXE3 ALOX12B	7.58e-07	4	11	2	C4551630
Disease	Harlequin Fetus	ALOXE3 ALOX12B	7.58e-07	4	11	2	C0239849
Disease	Collodion Fetus	ALOXE3 ALOX12B	7.58e-07	4	11	2	C3543867
Disease	Ichthyosis Congenita II	ALOXE3 ALOX12B	7.58e-07	4	11	2	C3536797
Disease	Congenital ichthyosis	ALOXE3 ALOX12B	1.26e-06	5	11	2	C0020758
Disease	Congenital ichthyosis of skin	ALOXE3 ALOX12B	6.94e-06	11	11	2	cv:C0020758
Disease	Congenital Nonbullous Ichthyosiform Erythroderma	ALOXE3 ALOX12B	6.94e-06	11	11	2	C0079154
Disease	melanoma	OSBPL6 MX2	9.70e-04	126	11	2	EFO_0000756
Disease	lung adenocarcinoma	PDE3A NAF1	1.84e-03	174	11	2	EFO_0000571
Disease	neuritic plaque measurement	OSBPL6 KCND3	7.15e-03	349	11	2	EFO_0006798
Disease	Myopia	OSBPL6 PDE3A	8.64e-03	385	11	2	HP_0000545
Disease	PR interval	PDE3A KCND3	1.40e-02	495	11	2	EFO_0004462
Disease	electrocardiography	OSBPL6 KCND3	1.59e-02	530	11	2	EFO_0004327
Disease	QT interval	OSBPL6 PDE3A	1.61e-02	534	11	2	EFO_0004682

Protein segments in the cluster

Peptide	Gene	Start	Entry
MAPWIMTPNTQPPEE	PADI1	291	Q9ULC6
AIGWMPVANCPMPLA	KCND3	16	Q9UK17
NMLPAGNPWLQMPTI	HSFY1	361	Q96LI6
AQPMAPPAQPMASWA	MAGEL2	316	Q9UJ55
SPSQMFPWMRPQAAP	HOXD8	181	P13378
WMPNAPSSMRQPPPQ	ALOXE3	601	Q9BYJ1
APSSSPDSWNNPVMM	PDE3A	471	Q14432
MDGKMQPNSFPWQSP	OSBPL6	216	Q9BZF3
WMPNFPASMRNPPIQ	ALOX12B	591	O75342
MAPPWVPAMGFTLAP	TSPO	1	P30536
MLPEQGPQPSTMPLW	UNQ6126/PRO20091	1	Q6UXV3
FGTVPPQMMFPPNWQ	MX2	36	P20592
PVNMGWATPNMAAHP	NAF1	446	Q96HR8