Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OPN1MW2 OR2T8 OR8A1 OR6B1 OR52R1 OPN1MW3 NPY6R OR7E24 OR2A12 OR2T33 MAS1 OR2T7 OR10AD1 MC2R OR56A5 MC5R OPN1LW OR5AK3P OR56A4 OR2T12 OPN1MW OR8D4 ADGRG4 CNR2 GPR179 HCRTR2 OR1D2

2.02e-188847327GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OPN1MW2 OR2T8 TGFBR1 OR8A1 OR6B1 OR52R1 OPN1MW3 NPY6R OR7E24 OR2A12 OR2T33 MAS1 OR2T7 OR10AD1 PKD1 MC2R OR56A5 MC5R OPN1LW OR5AK3P OR56A4 OR2T12 OPN1MW OR8D4 ADGRG4 CNR2 GPR179 HCRTR2 OR1D2

9.73e-1613537329GO:0004888
GeneOntologyMolecularFunctionolfactory receptor activity

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR2T7 OR10AD1 OR56A5 OR5AK3P OR56A4 OR2T12 OR8D4 OR1D2

3.74e-114317315GO:0004984
GeneOntologyMolecularFunctionG protein-coupled photoreceptor activity

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

2.18e-0715734GO:0008020
GeneOntologyMolecularFunctionphotoreceptor activity

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

3.77e-0717734GO:0009881
GeneOntologyMolecularFunctionG protein-coupled peptide receptor activity

NPY6R MAS1 MC2R MC5R HCRTR2

1.27e-04133735GO:0008528
GeneOntologyMolecularFunctionpeptide receptor activity

NPY6R MAS1 MC2R MC5R HCRTR2

1.62e-04140735GO:0001653
GeneOntologyMolecularFunctionsmall GTPase binding

DOCK1 EVI5 TBC1D13 GGA2 RHOBTB3 ECT2 FMNL1

1.71e-04321737GO:0031267
GeneOntologyMolecularFunctionprotein-cysteine S-myristoyltransferase activity

ZDHHC2 ZDHHC17

1.96e-046732GO:0019705
GeneOntologyMolecularFunctionmelanocortin receptor activity

MC2R MC5R

1.96e-046732GO:0004977
GeneOntologyMolecularFunctionprotein-cysteine S-stearoyltransferase activity

ZDHHC2 ZDHHC17

2.74e-047732GO:0140439
GeneOntologyMolecularFunctionGTPase binding

DOCK1 EVI5 TBC1D13 GGA2 RHOBTB3 ECT2 FMNL1

3.43e-04360737GO:0051020
GeneOntologyMolecularFunctionmyristoyltransferase activity

ZDHHC2 ZDHHC17

7.10e-0411732GO:0019107
GeneOntologyMolecularFunctionneuropeptide receptor activity

NPY6R MC2R HCRTR2

9.63e-0453733GO:0008188
GeneOntologyMolecularFunctionGTPase activator activity

DOCK1 EVI5 TBC1D13 HACD3 ECT2

3.56e-03279735GO:0005096
GeneOntologyMolecularFunctiontransforming growth factor beta binding

TGFBR1 TWSG1

4.05e-0326732GO:0050431
GeneOntologyMolecularFunctionprotein-cysteine S-palmitoyltransferase activity

ZDHHC2 ZDHHC17

4.05e-0326732GO:0019706
GeneOntologyMolecularFunctionprotein-cysteine S-acyltransferase activity

ZDHHC2 ZDHHC17

4.05e-0326732GO:0019707
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN4A

4.05e-0326732GO:0005248
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OPN1MW2 OR2T8 OR8A1 OR6B1 OR52R1 OPN1MW3 NPY6R OR7E24 OR2A12 OR2T33 RGS7BP MAS1 OR2T7 OR10AD1 MC2R OR56A5 MC5R OPN1LW OR5AK3P OR56A4 OR2T12 OPN1MW OR8D4 ADGRG4 CNR2 GPR179 HCRTR2 OR1D2

1.28e-1413957428GO:0007186
GeneOntologyBiologicalProcessdetection of stimulus

OPN1MW2 OR2T8 OR8A1 OR6B1 OR52R1 OPN1MW3 OR7E24 OR2A12 OR2T33 OR2T7 SCN1A OR10AD1 PKD1 OR56A5 OPN1LW OR5AK3P OR56A4 OR2T12 OPN1MW OR8D4 OR1D2

5.30e-147227421GO:0051606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR2T7 OR10AD1 OR56A5 OR5AK3P OR56A4 OR2T12 OR8D4 OR1D2

3.04e-114327415GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR2T7 OR10AD1 OR56A5 OR5AK3P OR56A4 OR2T12 OR8D4 OR1D2

8.52e-114657415GO:0007608
GeneOntologyBiologicalProcesssensory perception

OPN1MW2 OR2T8 OR8A1 OR6B1 OR52R1 OPN1MW3 OR7E24 OR2A12 OR2T33 OR2T7 SCN1A OR10AD1 OR56A5 OPN1LW OR5AK3P OR56A4 OR2T12 OPN1MW OR8D4 GPR179 OR1D2

9.63e-1110727421GO:0007600
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR2T7 OR10AD1 OR56A5 OR5AK3P OR56A4 OR2T12 OR8D4 OR1D2

1.53e-104857415GO:0050907
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR2T7 SCN1A OR10AD1 OR56A5 OR5AK3P OR56A4 OR2T12 OR8D4 OR1D2

1.95e-105827416GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR2T7 OR10AD1 OR56A5 OR5AK3P OR56A4 OR2T12 OR8D4 OR1D2

4.47e-105247415GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR2T7 OR10AD1 OR56A5 OR5AK3P OR56A4 OR2T12 OR8D4 OR1D2

8.06e-105477415GO:0007606
GeneOntologyBiologicalProcessdetection of external stimulus

OPN1MW2 OPN1MW3 SCN1A PKD1 OPN1LW OPN1MW

3.69e-05173746GO:0009581
GeneOntologyBiologicalProcessphototransduction

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

3.91e-0553744GO:0007602
GeneOntologyBiologicalProcessdetection of abiotic stimulus

OPN1MW2 OPN1MW3 SCN1A PKD1 OPN1LW OPN1MW

3.93e-05175746GO:0009582
GeneOntologyBiologicalProcesspositive regulation of cytokinesis

OPN1MW2 OPN1LW OPN1MW ECT2

4.53e-0555744GO:0032467
GeneOntologyBiologicalProcessdetection of visible light

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

5.22e-0557744GO:0009584
GeneOntologyBiologicalProcessdetection of light stimulus

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

1.69e-0477744GO:0009583
GeneOntologyBiologicalProcessregulation of cytokinesis

OPN1MW2 OPN1LW OPN1MW ECT2

4.44e-0499744GO:0032465
GeneOntologyBiologicalProcesspositive regulation of cell division

OPN1MW2 OPN1LW OPN1MW ECT2

5.35e-04104744GO:0051781
GeneOntologyBiologicalProcesspositive regulation of cell cycle

OPN1MW2 EIF4G1 OPN1LW PSMD10 OPN1MW ECT2 PGGT1B

6.39e-04407747GO:0045787
GeneOntologyBiologicalProcesscellular response to radiation

OPN1MW2 OPN1MW3 OPN1LW OPN1MW ECT2

6.66e-04194745GO:0071478
GeneOntologyCellularComponentphotoreceptor disc membrane

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

2.04e-0626744GO:0097381
HumanPhenoBlue cone monochromacy

OPN1LW OPN1MW

1.05e-052172HP:0007939
HumanPhenoCone monochromacy

OPN1LW OPN1MW

1.05e-052172HP:0011517
HumanPhenoReduced OCT-measured foveal thickness

OPN1LW OPN1MW

3.14e-053172HP:0030619
HumanPhenoAbnormal OCT-measured foveal thickness

OPN1LW OPN1MW

6.27e-054172HP:0030617
HumanPhenoAbnormal visual fixation

VPS13D OPN1LW OPN1MW

1.44e-0432173HP:0025404
DomainGPCR_Rhodpsn_7TM

OR2T8 OR8A1 OR6B1 OR52R1 OPN1MW3 OR7E24 OR2A12 OR2T33 MAS1 OR10AD1 MC2R OR56A5 MC5R OPN1LW OR56A4 OR2T12 OPN1MW OR8D4 CNR2 HCRTR2 OR1D2

1.76e-146706921IPR017452
Domain7tm_1

OR2T8 OR8A1 OR6B1 OR52R1 OPN1MW3 OR7E24 OR2A12 OR2T33 MAS1 OR10AD1 MC2R OR56A5 MC5R OPN1LW OR56A4 OR2T12 OPN1MW OR8D4 CNR2 HCRTR2 OR1D2

2.16e-146776921PF00001
DomainG_PROTEIN_RECEP_F1_1

OR2T8 OR8A1 OR6B1 OR52R1 OPN1MW3 OR7E24 OR2A12 OR2T33 MAS1 OR10AD1 MC2R OR56A5 MC5R OPN1LW OR56A4 OR2T12 OPN1MW OR8D4 CNR2 HCRTR2 OR1D2

2.71e-146856921PS00237
DomainG_PROTEIN_RECEP_F1_2

OR2T8 OR8A1 OR6B1 OR52R1 OPN1MW3 OR7E24 OR2A12 OR2T33 MAS1 OR10AD1 MC2R OR56A5 MC5R OPN1LW OR56A4 OR2T12 OPN1MW OR8D4 CNR2 HCRTR2 OR1D2

3.22e-146916921PS50262
DomainGPCR_Rhodpsn

OR2T8 OR8A1 OR6B1 OR52R1 OPN1MW3 OR7E24 OR2A12 OR2T33 MAS1 OR10AD1 MC2R OR56A5 MC5R OPN1LW OR56A4 OR2T12 OPN1MW OR8D4 CNR2 HCRTR2 OR1D2

3.31e-146926921IPR000276
DomainOlfact_rcpt

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR10AD1 OR56A5 OR56A4 OR2T12 OR8D4 OR1D2

1.73e-093936913IPR000725
DomainOpsin_red/grn

OPN1MW3 OPN1LW OPN1MW

4.83e-083693IPR000378
DomainARM-type_fold

DOCK1 NBEAL1 MROH2A UBR4 EIF4G1 USP24 VIRMA FMNL1 SDAD1

4.18e-06339699IPR016024
DomainOPSIN

OPN1MW3 OPN1LW OPN1MW

5.68e-0610693PS00238
DomainOpsin

OPN1MW3 OPN1LW OPN1MW

7.80e-0611693IPR001760
Domain7TM_GPCR_Srsx

OPN1MW3 MC2R MC5R CNR2 HCRTR2

5.87e-05112695SM01381
DomainMelcrt_ACTH_rcpt

MC2R MC5R

2.00e-046692IPR001671
DomainNa_channel_asu

SCN1A SCN4A

5.94e-0410692IPR001696
DomainNa_trans_assoc

SCN1A SCN4A

5.94e-0410692IPR010526
DomainNa_trans_assoc

SCN1A SCN4A

5.94e-0410692PF06512
Domainzf-DHHC

ZDHHC2 ZDHHC17

3.24e-0323692PF01529
DomainDHHC

ZDHHC2 ZDHHC17

3.82e-0325692PS50216
DomainZnf_DHHC_palmitoyltrfase

ZDHHC2 ZDHHC17

3.82e-0325692IPR001594
DomainGPS

PKD1 ADGRG4

6.99e-0334692SM00303
DomainGPS

PKD1 ADGRG4

7.40e-0335692PF01825
DomainGPS

PKD1 ADGRG4

7.81e-0336692PS50221
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR2T7 OR10AD1 OR56A5 OR56A4 OR2T12 OR8D4 OR1D2

2.52e-094176214M4072
PathwayREACTOME_SENSORY_PERCEPTION

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR2T7 OR10AD1 OR56A5 OPN1LW OR56A4 OR2T12 OPN1MW OR8D4 OR1D2

9.62e-096366216M41834
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR10AD1 OR56A5 OR56A4 OR2T12 OR8D4 OR1D2

1.07e-083896213M14091
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

OPN1MW2 OR8A1 OPN1MW3 NPY6R MAS1 MC2R MC5R OPN1LW CNR2

1.11e-07186629MM15994
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

OR6B1 NPY6R MAS1 MC2R MC5R OPN1LW OPN1MW CNR2 HCRTR2 OR1D2

1.77e-072606210M39397
PathwayREACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION

OPN1MW2 OPN1MW3 OPN1LW

4.47e-068623MM14880
PathwayWP_GPCRS_ODORANT

OPN1MW2 OR8A1 OPN1MW3 OR7E24 OPN1LW ADGRG4 GPR179

5.47e-06157627MM15872
PathwayREACTOME_OPSINS

OPN1MW2 OPN1MW3 OPN1LW

9.51e-0610623MM15063
PathwayWP_PEPTIDE_GPCRS

NPY6R MC2R MC5R HCRTR2

3.26e-0475624M39696
PathwayREACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION

OPN1LW OPN1MW

3.94e-047622M27157
PathwayREACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS

OPN1MW2 OPN1MW3 MC2R MC5R OPN1LW CNR2 HCRTR2

6.21e-04333627MM14963
PathwayREACTOME_OPSINS

OPN1LW OPN1MW

6.72e-049622M6285
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR10AD1 OR56A5 OR5AK3P OR56A4 OR2T12 OR8D4 OR1D2

1.83e-14340751411875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR10AD1 OR56A5 OR5AK3P OR56A4 OR2T12 OR8D4 OR1D2

1.83e-14340751411802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR10AD1 OR56A5 OR5AK3P OR56A4 OR2T12 OR8D4 OR1D2

2.06e-14343751432295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR2T8 OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR10AD1 OR56A5 OR5AK3P OR56A4 OR2T12 OR8D4 OR1D2

2.32e-14346751414611657
Pubmed

Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy.

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

1.99e-11475429386880
Pubmed

Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

9.95e-1157542937147
Pubmed

The human olfactory receptor gene family.

OR8A1 OR6B1 OR52R1 OR7E24 OR2A12 OR2T33 OR2T7 OR10AD1 OR56A4 OR2T12 OR8D4 OR1D2

1.91e-09541751214983052
Pubmed

Molecular determinants of human red/green color discrimination.

OPN1MW2 OPN1LW OPN1MW

9.63e-0937538185948
Pubmed

X-linked cone dystrophy caused by mutation of the red and green cone opsins.

OPN1MW2 OPN1LW OPN1MW

9.63e-09375320579627
Pubmed

Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375338410159
Pubmed

Chloride-dependent spectral tuning mechanism of L-group cone visual pigments.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375323350963
Pubmed

Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375320471354
Pubmed

Multiple hypothalamic cell populations encoding distinct visual information.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375321224225
Pubmed

Circadian Regulation of the Rod Contribution to Mesopic Vision in Mice.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375336216501
Pubmed

Spectral tuning of a circadian photopigment in a subterranean 'blind' mammal (Spalax ehrenbergi).

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375310567724
Pubmed

Extensive cone-dependent spectral opponency within a discrete zone of the lateral geniculate nucleus supporting mouse color vision.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375334111401
Pubmed

Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375314500905
Pubmed

Gene-based Therapy in a Mouse Model of Blue Cone Monochromacy.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375328751656
Pubmed

Rescue of M-cone Function in Aged Opn1mw-/- Mice, a Model for Late-Stage Blue Cone Monochromacy.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375331469404
Pubmed

The molecular genetics and evolution of red and green color vision in vertebrates.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375311545071
Pubmed

Mechanisms of spectral tuning in the mouse green cone pigment.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-0937539238068
Pubmed

Emergence of novel color vision in mice engineered to express a human cone photopigment.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375317379811
Pubmed

Co-expression of murine opsins facilitates identifying the site of cone adaptation.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-09375312511072
Pubmed

The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during early murine development.

OPN1MW2 OPN1MW3 OPN1LW

9.63e-0937537958444
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR2T8 OR8A1 OR6B1 OR7E24 OR2A12 OR2T7 OR10AD1 OR1D2

2.55e-0821975812213199
Pubmed

Visual responses in the dorsal lateral geniculate nucleus at early stages of retinal degeneration in rd1 PDE6β mice.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475331461375
Pubmed

Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-0847538088841
Pubmed

Modulation of Fast Narrowband Oscillations in the Mouse Retina and dLGN According to Background Light Intensity.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475328103478
Pubmed

Molecular biology of the visual pigments.

OPN1MW2 OPN1LW OPN1MW

3.85e-0847533303660
Pubmed

Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses to the Blue Colors Associated with Twilight.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475331846668
Pubmed

Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawn.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475326438865
Pubmed

Light/dark translocation of alphatransducin in mouse photoreceptor cells expressing G90D mutant opsin.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475317249565
Pubmed

Structural and functional rescue of cones carrying the most common cone opsin C203R missense mutation.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475338060327
Pubmed

Contribution of M-opsin-based color vision to refractive development in mice.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475334126082
Pubmed

Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475316567464
Pubmed

S-opsin knockout mice with the endogenous M-opsin gene replaced by an L-opsin variant.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475324801621
Pubmed

Melanopsin Contributions to the Representation of Images in the Early Visual System.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475328528909
Pubmed

Melanopsin-driven light adaptation in mouse vision.

OPN1MW2 OPN1MW3 OPN1LW

3.85e-08475325308073
Pubmed

Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.

OR2T8 OR7E24 OR2T7 OR2T12 OR1D2

5.21e-084675532126975
Pubmed

Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575336631163
Pubmed

Using Silent Substitution to Track the Mesopic Transition From Rod- to Cone-Based Vision in Mice.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575326818794
Pubmed

A common integration locus in type B retrovirus-induced thymic lymphomas.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-0857531333116
Pubmed

A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575322090509
Pubmed

Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575310723722
Pubmed

Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575327033727
Pubmed

Melanopsin-based brightness discrimination in mice and humans.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575322633808
Pubmed

The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575311055434
Pubmed

Enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor β2 and COUP-TFII.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575324058409
Pubmed

Variations in photoreceptor throughput to mouse visual cortex and the unique effects on tuning.

OPN1MW2 OPN1MW3 OPN1LW

9.60e-08575334099749
Pubmed

Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.

OPN1MW2 OPN1MW3 OPN1LW

1.92e-07675323288843
Pubmed

Reduced levels of dystrophin associated proteins in the brains of mice deficient for Dp71.

OPN1MW2 OPN1MW3 OPN1LW

1.92e-0767538872469
Pubmed

A thyroid hormone receptor that is required for the development of green cone photoreceptors.

OPN1MW2 OPN1MW3 OPN1LW

1.92e-07675311138006
Pubmed

Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase.

OPN1MW2 OPN1MW3 OPN1LW

1.92e-07675310395695
Pubmed

Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis.

OPN1MW2 OPN1MW3 OPN1LW

1.92e-07675317436273
Pubmed

Telomere-related markers for the pseudoautosomal region of the mouse genome.

OPN1MW2 OPN1MW3 OPN1LW

1.92e-0767531549575
Pubmed

Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-07775318974269
Pubmed

Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-0777538001979
Pubmed

NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-07775318199774
Pubmed

Mapping of the murine tbl1 gene reveals a new rearrangement between mouse and human X Chromosomes.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-0777539880679
Pubmed

Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-0777538378320
Pubmed

Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-07775330799247
Pubmed

Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-07775316574740
Pubmed

Rods progressively escape saturation to drive visual responses in daylight conditions.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-07775329180667
Pubmed

Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.

OPN1MW2 OPN1MW3 OPN1LW

3.35e-07775319332056
Pubmed

Localization of the mdx mutation within the mouse dystrophin gene.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-0787532903046
Pubmed

Genetic mapping on the mouse X chromosome of human cDNA clones for the fragile X and Hunter syndromes.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-0787531572654
Pubmed

Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875321813673
Pubmed

X-chromosome gene order in different Mus species crosses.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-0787533416629
Pubmed

The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875312651948
Pubmed

Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875331163126
Pubmed

Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875320203194
Pubmed

Tubby is required for trafficking G protein-coupled receptors to neuronal cilia.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875323351594
Pubmed

A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3).

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875310725384
Pubmed

Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875316043864
Pubmed

Nr2e3 functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates retinitis pigmentosa and enhanced S-cone syndrome models.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-07875333007388
Pubmed

Linkage of amelogenin (Amel) to the distal portion of the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

5.35e-0787531675194
Pubmed

Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-07975314742273
Pubmed

Feedback induction of a photoreceptor-specific isoform of retinoid-related orphan nuclear receptor β by the rod transcription factor NRL.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-07975325296752
Pubmed

Comparative mapping of the actin-binding protein 280 genes in human and mouse.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-0797538088838
Pubmed

ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-07975321850176
Pubmed

Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-07975328370415
Pubmed

IFT20 is required for opsin trafficking and photoreceptor outer segment development.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-07975321307337
Pubmed

Multilocus molecular mapping of the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-0797532906327
Pubmed

A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-07975327669145
Pubmed

Close linkage of the murine locus bare patches to the X-linked visual pigment gene: implications for mapping human X-linked dominant chondrodysplasia punctata.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-0797531973136
Pubmed

Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development.

OPN1MW2 OPN1MW3 OPN1LW

8.02e-07975312407160
Pubmed

Mapping of ornithine aminotransferase gene sequences to mouse chromosomes 7, X, and 3.

OPN1MW2 OPN1MW3 OPN1LW

1.14e-06107531349842
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

OPN1MW2 OPN1LW OPN1MW

1.14e-06107538857542
Pubmed

Linkage of a gene for neural cell adhesion molecule, L1 (CamL1) to the Rsvp region of the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

1.14e-06107531964443
Pubmed

Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye.

OPN1MW2 OPN1MW3 OPN1LW

1.14e-061075321148184
Pubmed

Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function.

OPN1MW2 OPN1MW3 OPN1LW

1.14e-061075331949211
Pubmed

Comparative mapping on the mouse and human X chromosomes of a human cDNA clone encoding the vasopressin renal-type receptor (AVP2R).

OPN1MW2 OPN1MW3 OPN1LW

1.14e-06107538449515
Pubmed

The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.

OPN1MW2 OPN1MW3 OPN1LW

1.14e-061075332236127
Pubmed

Physical mapping of the loci Gabra3, DXPas8, CamL1, and Rsvp in a region of the mouse X chromosome homologous to human Xq28.

OPN1MW2 OPN1MW3 OPN1LW

1.14e-06107531684949
Pubmed

Mapping of the phosphorylase kinase alpha subunit gene on the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

1.14e-06107531973380
Pubmed

Physical linkage of the A-raf-1, properdin, synapsin I, and TIMP genes on the human and mouse X chromosomes.

OPN1MW2 OPN1MW3 OPN1LW

1.57e-06117531572636
Pubmed

Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice.

OPN1MW2 OPN1MW3 OPN1LW

1.57e-061175324421398
Pubmed

Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

2.09e-06127531679744
Pubmed

The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors.

OPN1MW2 OPN1MW3 OPN1LW

2.09e-061275319812316
Pubmed

MAP4K4 is involved in the neuronal development of retinal photoreceptors.

OPN1MW2 OPN1MW3 OPN1LW

2.09e-061275337290629
Cytoband1q44

OR2T8 OR2T33 OR2T7 OR2T12

3.33e-051107541q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2T8 OR2T33 OR2T7 OR2T12

6.01e-05128754chr1q44
Cytoband18p11.2

MC2R MC5R

9.41e-05975218p11.2
CytobandEnsembl 112 genes in cytogenetic band chrXq28

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

4.23e-04213754chrXq28
Cytoband4p12

TEC TXK

4.91e-04207524p12
CytobandXq28

OPN1MW2 OPN1LW OPN1MW

3.05e-03176753Xq28
Cytoband7q35

OR6B1 OR2A12

3.70e-03557527q35
Cytoband11p15.4

OR52R1 OR56A5 OR56A4

4.37e-0320075311p15.4
CytobandEnsembl 112 genes in cytogenetic band chr18p11

MC2R MC5R TWSG1

5.00e-03210753chr18p11
CytobandEnsembl 112 genes in cytogenetic band chr7q35

OR6B1 OR2A12

5.28e-0366752chr7q35
GeneFamilyOpsin receptors

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

3.09e-0811584215
GeneFamilyOlfactory receptors, family 2

OR2T8 OR2A12 OR2T33 OR2T7 OR2T12

3.07e-05113585149
GeneFamilyMelanocortin receptors

MC2R MC5R

1.01e-045582236
GeneFamilyOlfactory receptors, family 56

OR56A5 OR56A4

3.59e-049582167
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN4A

3.59e-0495821203
GeneFamilyZinc fingers DHHC-type|Ankyrin repeat domain containing

ZDHHC2 ZDHHC17

2.67e-032458276
DrugA-26

MC2R MC5R OPN1LW OPN1MW

9.87e-0725704CID000037120
Diseaseblue cone monochromacy (implicated_via_orthology)

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

3.08e-114714DOID:0050679 (implicated_via_orthology)
DiseaseCone monochromatism

OPN1LW OPN1MW

5.71e-062712C0339537
DiseaseBLUE CONE MONOCHROMACY

OPN1LW OPN1MW

5.71e-062712303700
DiseaseCone monochromatism

OPN1LW OPN1MW

5.71e-062712cv:C0339537
Diseaseblue cone monochromacy (is_implicated_in)

OPN1LW OPN1MW

5.71e-062712DOID:0050679 (is_implicated_in)
DiseaseBORNHOLM EYE DISEASE

OPN1LW OPN1MW

5.71e-062712C3159311
DiseaseAchromatopsia incomplete, X-linked

OPN1LW OPN1MW

5.71e-062712C2931753
DiseaseRed-green dyschromatopsia

OPN1LW OPN1MW

5.71e-062712cv:C0155016
Diseasetyrosine-protein kinase TEC measurement

TEC TEC

3.41e-054712EFO_0020830
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN4A

2.54e-0410712DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN4A

2.54e-0410712DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN4A

3.71e-0412712DOID:0060170 (implicated_via_orthology)
Diseasecystathionine measurement

TEC TEC

9.51e-0419712EFO_0010474
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A CNR2

1.28e-0322712DOID:2030 (implicated_via_orthology)
Diseasehip bone mineral density, fat body mass

MC2R MC5R

1.28e-0322712EFO_0005409, EFO_0007702
Diseaselean mass-adjusted fat body mass, femoral neck bone mineral density

MC2R MC5R

1.93e-0327712EFO_0007785, EFO_0009890
DiseaseCone-Rod Dystrophy 2

OPN1LW OPN1MW

2.22e-0329712C3489532

Protein segments in the cluster

PeptideGeneStartEntry
MCTVVYFDDCMSIHQ

TWSG1

166

Q9GZX9
NLCVMDHFMKIFLYC

CFAP54

1606

Q96N23
YFCLIFLMNLSMFCT

ADGRG4

2901

Q8IZF6
ILVLAVLMLMYYCCR

ADAM19

711

Q9H013
ILVVGMDCEMHVYCQ

DMXL1

1226

Q9Y485
FAFCSMLCLINSMVN

CNR2

281

P34972
LEDMMLLFDCLSVCY

NBEAL1

1546

Q6ZS30
IQLQCCLEMYTTEML

RGS7BP

126

Q6MZT1
VTRMVVVMIFAYCVC

OPN1LW

266

P04000
VQSYMIVLMVTCCIT

OPN1MW3

216

P0DN78
LYCTSMMNLVLCFTG

ECT2

171

Q9H8V3
ICANVMEYCQSLMLQ

NUP205

1756

Q92621
VQSYMIVLMVTCCIT

OPN1MW2

216

P0DN77
CTFMVMAYDRYVAIC

OR56A4

116

Q8NGH8
VCVISECYMLAAMAC

OR8D4

106

Q8NGM9
FAITECLILVMMCYD

OR2A12

106

Q8NGT7
CLILVMMCYDRYVAI

OR2A12

111

Q8NGT7
HIVSFVCCMTQMYFV

OR10AD1

91

Q8NGE0
SVFENAMYICCVLML

OR2T12

191

Q8NG77
CLVTTMEYVMCIDRE

MAS1

161

P04201
MYFCQMLAVVETINA

HACD3

191

Q9P035
YKLFLMFCMAGLCLI

MGAT3

6

Q09327
CMLAIFLSMLVSYRC

GPR179

391

Q6PRD1
YETAMYVCCIMMLLI

OR2T7

186

P0C7T2
SVFENAMYICCVLML

OR2T8

191

A6NH00
ELGLCMYQFECMIQE

EVI5

286

O60447
YALTVLEMCMNHCGE

GGA2

81

Q9UJY4
SVFENAMYICCVLML

OR2T33

191

Q8NG76
DCYLLAIMAMDCYVA

OR5AK3P

111

Q8NH89
VQSYMIVLMVTCCIT

OPN1MW

216

P04001
CTFMIMAYDRYVAIC

OR56A5

116

P0C7T3
CFAQMYAIHCFVAME

OR56B2P

106

Q8NGI1
GVLMAMALDCYVAIC

OR52R1

116

Q8NGF1
CVMCIHFTIIYTLMD

NPY6R

86

Q99463
IFRYLPLQDIMCMEC

FBXO38

41

Q6PIJ6
CFFLVTYMAPLCLMV

HCRTR2

226

O43614
EMLVAYCMFQLECCV

DEFB134

46

Q4QY38
FVACMTAILRQMEDY

DOCK1

931

Q14185
FSVAYANMCRCLMAL

EIF4G1

811

Q04637
MYFFVCSLAVADMLV

MC5R

71

P33032
DVHVCIMCLRAIMNY

FMNL1

226

O95466
FLVFVIAECYMLTVM

OR8A1

121

Q8NGG7
CAVCLVTYMVMAAIL

PKD1

3081

P98161
MEGCVSNLMVCNLAY

PSMD10

1

O75832
AMCLLICAEMYQVSR

RHOBTB3

491

O94955
YIFCEMYVLLRMACS

OR1D2

176

P34982
YVSSCQDICLKMAFM

MROH2A

811

A6NES4
DMRFVYCASCICYML

PGGT1B

171

P53609
CIALMAVIGEYLCMR

SYS1

126

Q8N2H4
CLAVMTLMAAVYTIA

SLC35A1

16

P78382
ICIVLNTLFMAMEHY

SCN4A

586

P35499
LLSMCQDVCEGMEYL

TEC

466

P42680
VCIMMVVAAAYGCIY

LRTM2

321

Q8N967
MLLSVMAYDRFVAIC

OR7E24

131

Q6IFN5
FMARCLQVVMCHLFT

FBXL18

636

Q96ME1
DFQEYCVFLSCIAMM

S100A4

71

P26447
LAELVMFMAQISHCY

SDAD1

56

Q9NVU7
LCMIQLYFFIALMCT

OR6B1

96

O95007
ALMCTECVLLAAMAY

OR6B1

106

O95007
RILATRCMMQAVYFC

DIS3

741

Q9Y2L1
ICIVLNTLFMAMEHY

SCN1A

776

P35498
FVCISLMLMVYICHN

TGFBR1

136

P36897
CACYMSLFQVNGMLI

MC2R

251

Q01718
MIKIMQEYGEVTCCL

TMEM94

986

Q12767
RCIYQVSCMLCAESM

SPRED1

361

Q7Z699
FVVICCVMMVLLYFF

SPPL2A

226

Q8TCT8
YVMIAIFCIASAMSL

SPPL2A

246

Q8TCT8
NRFDFLLLVCCAMLM

TBC1D13

346

Q9NVG8
ISLCCMVVFTMAYIM

VSIG4

291

Q9Y279
DYEICIHTNSMCFTM

SNX10

31

Q9Y5X0
AVLLMCQMYQISCLG

ZDHHC17

546

Q8IUH5
MLLSVCQDICEGMEY

TXK

366

P42681
MALVCNVFDMLYQLA

USP24

1076

Q9UPU5
EQVVCLMAYHLLFAM

ZDHHC2

51

Q9UIJ5
MILECTCHIMSYLAD

UBR4

1591

Q5T4S7
ALFCAYMEAAISNIM

SLC14A2

376

Q15849
YNCLLTCVRTMMFLA

VIRMA

1341

Q69YN4
VYTCMCFLIDMVNVS

VPS13D

2281

Q5THJ4