Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glutamate-gated calcium ion channel activity	GRIN2C GRIN2D	1.57e-04	8	48	2	GO:0022849
GeneOntologyMolecularFunction	NMDA glutamate receptor activity	GRIN2C GRIN2D	1.57e-04	8	48	2	GO:0004972
GeneOntologyBiologicalProcess	head development	SEMA6B CWH43 HTR6 SZT2 ARX EXT1 GRIN2C GRIN2D HERC1 AXIN1 SEZ6	7.96e-06	919	49	11	GO:0060322
GeneOntologyBiologicalProcess	brain development	SEMA6B CWH43 HTR6 SZT2 ARX EXT1 GRIN2C GRIN2D HERC1 SEZ6	2.79e-05	859	49	10	GO:0007420
GeneOntologyCellularComponent	NMDA selective glutamate receptor complex	GRIN2C GRIN2D	1.92e-04	9	49	2	GO:0017146
Domain	Glyco_trans_31	B3GNT4 B3GNT9	6.97e-04	16	46	2	IPR002659
Domain	Galactosyl_T	B3GNT4 B3GNT9	6.97e-04	16	46	2	PF01762
Domain	Iontro_rcpt	GRIN2C GRIN2D	8.85e-04	18	46	2	IPR001320
Domain	Lig_chan-Glu_bd	GRIN2C GRIN2D	8.85e-04	18	46	2	PF10613
Domain	Iono_rcpt_met	GRIN2C GRIN2D	8.85e-04	18	46	2	IPR001508
Domain	Glu/Gly-bd	GRIN2C GRIN2D	8.85e-04	18	46	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIN2C GRIN2D	8.85e-04	18	46	2	SM00918
Domain	Lig_chan	GRIN2C GRIN2D	8.85e-04	18	46	2	PF00060
Domain	PBPe	GRIN2C GRIN2D	8.85e-04	18	46	2	SM00079
Domain	Laminin_EGF	NTN5 MEGF10	3.35e-03	35	46	2	PF00053
Domain	EGF_Lam	NTN5 MEGF10	3.35e-03	35	46	2	SM00180
Domain	EGF_1	FBN1 ZAN NTN5 MEGF10	3.53e-03	255	46	4	PS00022
Domain	ANF_lig-bd_rcpt	GRIN2C GRIN2D	3.74e-03	37	46	2	IPR001828
Domain	ANF_receptor	GRIN2C GRIN2D	3.74e-03	37	46	2	PF01094
Domain	Laminin_EGF	NTN5 MEGF10	3.94e-03	38	46	2	IPR002049
Domain	EGF_2	FBN1 ZAN NTN5 MEGF10	4.05e-03	265	46	4	PS01186
Domain	Peripla_BP_I	GRIN2C GRIN2D	4.15e-03	39	46	2	IPR028082
Pathway	REACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS	GRIN2C GRIN2D	5.29e-05	5	33	2	MM15655
Pathway	KEGG_MEDICUS_REFERENCE_TRANSPORT_OF_CALCIUM	GRIN2C GRIN2D	5.29e-05	5	33	2	M47667
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PDYN_TO_TRANSPORT_OF_CALCIUM	GRIN2C GRIN2D	7.92e-05	6	33	2	M47668
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_LIGAND_GATED_CA2_CHANNEL	GRIN2C GRIN2D	3.46e-04	12	33	2	M47953
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_TRANSPORT_OF_CALCIUM	GRIN2C GRIN2D	5.47e-04	15	33	2	M47691
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_TRANSPORT_OF_CALCIUM	GRIN2C GRIN2D	7.94e-04	18	33	2	M47761
Pathway	WP_NRXN1_DELETION_SYNDROME	GRIN2C GRIN2D	7.94e-04	18	33	2	M48098
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TRANSPORT_OF_CALCIUM	GRIN2C GRIN2D	8.86e-04	19	33	2	M47677
Pathway	BIOCARTA_NOS1_PATHWAY	GRIN2C GRIN2D	9.83e-04	20	33	2	MM1445
Pathway	REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES	GRIN2C GRIN2D	9.83e-04	20	33	2	MM15485
Pathway	REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES	GRIN2C GRIN2D	1.09e-03	21	33	2	M27736
Pathway	BIOCARTA_NOS1_PATHWAY	GRIN2C GRIN2D	1.09e-03	21	33	2	M11650
Pathway	REACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION	GRIN2C GRIN2D	1.09e-03	21	33	2	M838
Pathway	REACTOME_NEGATIVE_REGULATION_OF_NMDA_RECEPTOR_MEDIATED_NEURONAL_TRANSMISSION	GRIN2C GRIN2D	1.09e-03	21	33	2	M27944
Pathway	REACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION	GRIN2C GRIN2D	1.19e-03	22	33	2	MM15104
Pathway	REACTOME_LONG_TERM_POTENTIATION	GRIN2C GRIN2D	1.30e-03	23	33	2	M27949
Pubmed	In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.	GRIN2C GRIN2D	2.19e-06	2	52	2	29651654
Pubmed	Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.	GRIN2C GRIN2D	2.19e-06	2	52	2	31110197
Pubmed	Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.	GRIN2C GRIN2D	2.19e-06	2	52	2	29317596
Pubmed	Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.	GRIN2C GRIN2D	2.19e-06	2	52	2	35057644
Pubmed	NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.	GRIN2C GRIN2D	2.19e-06	2	52	2	33766086
Pubmed	A mental retardation gene, motopsin/prss12, modulates cell morphology by interaction with seizure-related gene 6.	PRSS12 SEZ6	2.19e-06	2	52	2	23770366
Pubmed	NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback.	GRIN2C GRIN2D	2.19e-06	2	52	2	31786200
Pubmed	Auditory pathway and auditory brainstem response in mice lacking NMDA receptor epsilon 1 and epsilon 4 subunits.	GRIN2C GRIN2D	6.57e-06	3	52	2	9718984
Pubmed	Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens.	GRIN2C GRIN2D	6.57e-06	3	52	2	35867797
Pubmed	Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model.	GRIN2C GRIN2D	6.57e-06	3	52	2	33421565
Pubmed	Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels.	GRIN2C GRIN2D	6.57e-06	3	52	2	9480759
Pubmed	Functional correlation of NMDA receptor epsilon subunits expression with the properties of single-channel and synaptic currents in the developing cerebellum.	GRIN2C GRIN2D	1.31e-05	4	52	2	8699248
Pubmed	Role of the carboxy-terminal region of the GluR epsilon2 subunit in synaptic localization of the NMDA receptor channel.	GRIN2C GRIN2D	1.31e-05	4	52	2	9768843
Pubmed	Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.	GRIN2C GRIN2D	1.31e-05	4	52	2	36309015
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	QSOX1 TUT4 FBN1 ARX NR1D1 MEGF10 AXIN1	1.93e-05	560	52	7	21653829
Pubmed	Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.	GRIN2C GRIN2D	2.19e-05	5	52	2	26875626
Pubmed	Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.	GRIN2C GRIN2D	2.19e-05	5	52	2	26919761
Pubmed	Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem.	GRIN2C GRIN2D	2.19e-05	5	52	2	7518475
Pubmed	Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum.	GRIN2C GRIN2D	2.19e-05	5	52	2	7518474
Pubmed	Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit.	GRIN2C GRIN2D	2.19e-05	5	52	2	9147327
Pubmed	Differential distributions of the NMDA receptor channel subunit mRNAs in the mouse retina.	GRIN2C GRIN2D	2.19e-05	5	52	2	7510577
Pubmed	Neurotransmission and bipolar disorder: a systematic family-based association study.	GRIN2C GRIN2D	2.19e-05	5	52	2	18444252
Pubmed	Distinct gene expression of the N-methyl-D-aspartate receptor channel subunit in peripheral neurons of the mouse sensory ganglia and adrenal gland.	GRIN2C GRIN2D	2.19e-05	5	52	2	8015722
Pubmed	Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain.	GRIN2C GRIN2D	2.19e-05	5	52	2	15003177
Pubmed	GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions.	GRIN2C GRIN2D	2.19e-05	5	52	2	7723623
Pubmed	Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene.	GRIN2C GRIN2D	2.19e-05	5	52	2	8756432
Pubmed	Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor.	GRIN2C GRIN2D	2.19e-05	5	52	2	12082569
Pubmed	Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain.	GRIN2C GRIN2D	2.19e-05	5	52	2	21945132
Pubmed	Differential interaction of NMDA receptor subtypes with the post-synaptic density-95 family of membrane associated guanylate kinase proteins.	GRIN2C GRIN2D	2.19e-05	5	52	2	18233995
Pubmed	Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex.	GRIN2C GRIN2D	2.19e-05	5	52	2	11488959
Pubmed	Developmental changes in distribution of NMDA receptor channel subunit mRNAs.	GRIN2C GRIN2D	2.19e-05	5	52	2	1493227
Pubmed	N-methyl-D-aspartic acid receptor structure and function.	GRIN2C GRIN2D	2.19e-05	5	52	2	8036251
Pubmed	NMDA receptor activation by HIV-Tat protein is clade dependent.	GRIN2C GRIN2D	2.19e-05	5	52	2	19020013
Pubmed	Distinct spatiotemporal distributions of the N-methyl-D-aspartate receptor channel subunit mRNAs in the mouse cervical cord.	GRIN2C GRIN2D	2.19e-05	5	52	2	7929904
Pubmed	Cortical consequences of HIV-1 Tat exposure in rats are enhanced by chronic cocaine.	GRIN2C GRIN2D	3.28e-05	6	52	2	25760043
Pubmed	A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity.	GRIN2C GRIN2D	3.28e-05	6	52	2	23665428
Pubmed	Altered gene expression of the N-methyl-D-aspartate receptor channel subunits in Purkinje cells of the staggerer mutant mouse.	GRIN2C GRIN2D	3.28e-05	6	52	2	8996814
Pubmed	Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo.	GRIN2C GRIN2D	3.28e-05	6	52	2	9458051
Pubmed	NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit.	GRIN2C GRIN2D	3.28e-05	6	52	2	15317856
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA6B HIVEP2 SZT2 AOC2 GRIN2D HERC1 SRCAP HR NOD2	3.44e-05	1105	52	9	35748872
Pubmed	Early onset of NMDA receptor GluR epsilon 1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus.	GRIN2C GRIN2D	4.58e-05	7	52	2	12103442
Pubmed	Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures.	GRIN2C GRIN2D	4.58e-05	7	52	2	23267846
Pubmed	Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death.	GRIN2C GRIN2D	4.58e-05	7	52	2	19036954
Pubmed	Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.	GRIN2C GRIN2D	4.58e-05	7	52	2	22833210
Pubmed	HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors.	GRIN2C GRIN2D	4.58e-05	7	52	2	22940423
Pubmed	Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons.	GRIN2C GRIN2D	6.10e-05	8	52	2	8804048
Pubmed	HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes.	GRIN2C GRIN2D	6.10e-05	8	52	2	17360663
Pubmed	Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.	GRIN2C GRIN2D	6.10e-05	8	52	2	8724036
Pubmed	The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid.	GRIN2C GRIN2D	6.10e-05	8	52	2	8845955
Pubmed	Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.	GRIN2C GRIN2D	6.10e-05	8	52	2	8822372
Pubmed	Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.	GRIN2C GRIN2D	6.10e-05	8	52	2	21106831
Pubmed	HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons.	GRIN2C GRIN2D	6.10e-05	8	52	2	8563977
Pubmed	HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures.	GRIN2C GRIN2D	6.10e-05	8	52	2	8821747
Pubmed	Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures.	GRIN2C GRIN2D	6.10e-05	8	52	2	10448428
Pubmed	Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity.	GRIN2C GRIN2D	6.10e-05	8	52	2	7695237
Pubmed	Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.	GRIN2C GRIN2D	6.10e-05	8	52	2	8955056
Pubmed	Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system.	GRIN2C GRIN2D	6.10e-05	8	52	2	10555109
Pubmed	Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems.	GRIN2C GRIN2D	7.84e-05	9	52	2	17526495
Pubmed	D1/NMDA receptors and concurrent methamphetamine+ HIV-1 Tat neurotoxicity.	GRIN2C GRIN2D	7.84e-05	9	52	2	22552781
Pubmed	Activation of cannabinoid type 2 receptors inhibits HIV-1 envelope glycoprotein gp120-induced synapse loss.	GRIN2C GRIN2D	7.84e-05	9	52	2	21670103
Pubmed	Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS.	GRIN2C GRIN2D	7.84e-05	9	52	2	21491143
Pubmed	Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity.	GRIN2C GRIN2D	7.84e-05	9	52	2	16554481
Pubmed	PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.	GRIN2C GRIN2D	7.84e-05	9	52	2	9892651
Pubmed	N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons.	GRIN2C GRIN2D	9.79e-05	10	52	2	19332541
Pubmed	Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.	GRIN2C GRIN2D	1.20e-04	11	52	2	8581564
Pubmed	HIV-1 Tat-mediated apoptosis in human blood-retinal barrier-associated cells.	GRIN2C GRIN2D	1.20e-04	11	52	2	24739951
Pubmed	CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.	GRIN2C GRIN2D	1.20e-04	11	52	2	9647694
Pubmed	Effects of SDF-1alpha and gp120IIIB on apoptotic pathways in SK-N-SH neuroblastoma cells.	GRIN2C GRIN2D	1.20e-04	11	52	2	16481105
Pubmed	Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle.	GRIN2C GRIN2D	1.43e-04	12	52	2	12815021
Pubmed	Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.	GRIN2C GRIN2D	1.43e-04	12	52	2	11937501
Pubmed	Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation.	GRIN2C GRIN2D	1.43e-04	12	52	2	8665664
Pubmed	Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways.	GRIN2C GRIN2D	1.97e-04	14	52	2	15749123
Pubmed	Neurotoxicity of human immunodeficiency virus-1: viral proteins and axonal transport.	GRIN2C GRIN2D	2.27e-04	15	52	2	21948112
Pubmed	Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.	GRIN2C GRIN2D	2.27e-04	15	52	2	10479680
Pubmed	A genomic atlas of mouse hypothalamic development.	ARX NR1D1 AXIN1 SEZ6	2.54e-04	205	52	4	20436479
Pubmed	Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.	GRIN2C GRIN2D	2.94e-04	17	52	2	24086760
Pubmed	Gene structure and chromosomal localization of the mouse NMDA receptor channel subunits.	GRIN2C GRIN2D	3.30e-04	18	52	2	9011744
Pubmed	The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.	GRIN2C GRIN2D	4.52e-04	21	52	2	22114277
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIN2C GRIN2D	5.93e-04	24	52	2	35746896
Pubmed	Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.	DISP1 AXIN1	6.43e-04	25	52	2	29475039
Pubmed	Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.	GRIN2C GRIN2D	6.96e-04	26	52	2	9745929
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	HTR6 GRIN2C GRIN2D	7.45e-04	118	52	3	19156168
Pubmed	Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum.	GRIN2C GRIN2D	9.29e-04	30	52	2	18603407
Pubmed	ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.	FBN1 EXT1	9.29e-04	30	52	2	32882513
Pubmed	Role of Tat protein in HIV neuropathogenesis.	GRIN2C GRIN2D	1.12e-03	33	52	2	19526283
Pubmed	HIV-1 subtypes B and C Tat differentially impact synaptic plasticity expression and implicates HIV-associated neurocognitive disorders.	GRIN2C GRIN2D	1.49e-03	38	52	2	25613138
GeneFamily	Glutamate ionotropic receptor NMDA type subunits	GRIN2C GRIN2D	5.94e-05	7	31	2	1201
GeneFamily	Beta 3-glycosyltransferases	B3GNT4 B3GNT9	7.67e-04	24	31	2	426
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	B3GNT9 FBN1 PRSS12 ARX GASK1A	1.44e-06	169	51	5	335619507857383c3b0b507cdf05d786ed59e585
Drug	L-cycloserine	AOC2 SMPD1 GRIN2C GRIN2D	1.45e-05	66	51	4	CID000000401
Drug	cis-2,3-piperidine dicarboxylic acid	GRIN2C GRIN2D NOD2	4.12e-05	30	51	3	CID000001226
Drug	5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione	GRIN2C GRIN2D	4.90e-05	5	51	2	ctd:C498554
Drug	2-Aminoadipic Acid	GRIN2C GRIN2D	4.90e-05	5	51	2	ctd:D015074
Drug	(2S,3R)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid	GRIN2C GRIN2D	4.90e-05	5	51	2	ctd:C491996
Drug	SDZ EAA 494	GRIN2C GRIN2D	4.90e-05	5	51	2	ctd:C065286
Drug	Acetaminophen [103-90-2]; Down 200; 26.4uM; MCF7; HT_HG-U133A	TUT4 TTC28 PRR36 HR VEGFB	7.29e-05	194	51	5	5384_DN
Drug	Naphthols	GRIN2C GRIN2D	7.34e-05	6	51	2	ctd:D009284
Drug	Meperidine	GRIN2C GRIN2D	7.34e-05	6	51	2	DB00454
Drug	1,5-(diethylamino)piperidine	GRIN2C GRIN2D	7.34e-05	6	51	2	CID000004025
Drug	Tetracaone hydrochloride [136-47-0]; Up 200; 13.2uM; MCF7; HT_HG-U133A	SEMA6B B3GNT4 PRR36 SRCAP HR	7.84e-05	197	51	5	2888_UP
Drug	Benzylpenicillin sodium [69-57-8]; Down 200; 11.2uM; PC3; HT_HG-U133A	B3GNT4 FBN1 TTC28 SRCAP AXIN1	7.84e-05	197	51	5	4501_DN
Drug	6-Furfurylaminopurine [525-79-1]; Up 200; 18.6uM; MCF7; HT_HG-U133A	SEMA6B TUT4 PRR36 HR NOD2	8.03e-05	198	51	5	6073_UP
Drug	Streptozotocin [18883-66-4]; Up 200; 15uM; MCF7; HT_HG-U133A	B3GNT4 TUT4 PRR36 SZT2 SRCAP	8.22e-05	199	51	5	6098_UP
Drug	Sertaconazole nitrate [99592-39-9]; Up 200; 8uM; HL60; HT_HG-U133A	FBN1 GRIN2C SRCAP AXIN1 HR	8.42e-05	200	51	5	6128_UP
Drug	Pipemidic acid [51940-44-4]; Up 200; 13.2uM; MCF7; HT_HG-U133A	SEMA6B B3GNT4 CWH43 PRSS12 SRCAP	8.42e-05	200	51	5	6470_UP
Drug	Tropicamide [1508-75-4]; Up 200; 14uM; MCF7; HT_HG-U133A	FBN1 SMPD1 SRCAP AXIN1 HR	8.42e-05	200	51	5	3619_UP
Drug	Tenocyclidine	GRIN2C GRIN2D	1.03e-04	7	51	2	DB01520
Drug	3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid	GRIN2C GRIN2D	1.03e-04	7	51	2	ctd:C050592
Drug	tetrazol-5-yl)glycine	GRIN2C GRIN2D	1.03e-04	7	51	2	CID000126383
Drug	homoquinolinate	GRIN2C GRIN2D	1.03e-04	7	51	2	CID003080554
Drug	S)-piperazine-2-carboxylic acid	GRIN2C GRIN2D	1.03e-04	7	51	2	CID001502069
Drug	Oxadiazoles	CWH43 GRIN2C GRIN2D	1.31e-04	44	51	3	ctd:D010069
Drug	AC1L1JJR	HTR6 GRIN2C GRIN2D	1.31e-04	44	51	3	CID000005072
Drug	6-chloroquinoxaline-2,3-diol	GRIN2C GRIN2D	1.37e-04	8	51	2	CID000081143
Drug	ES-242-1	GRIN2C GRIN2D	1.37e-04	8	51	2	CID000131976
Drug	SDZ 220-581	GRIN2C GRIN2D	1.37e-04	8	51	2	CID000128019
Drug	3alpha5betaHS	GRIN2C GRIN2D	1.37e-04	8	51	2	CID000165024
Drug	neramexane	GRIN2C GRIN2D	1.37e-04	8	51	2	CID006433106
Drug	piperazine-2,3-dicarboxylic acid	GRIN2C GRIN2D	1.37e-04	8	51	2	CID000280973
Drug	L-687,414	GRIN2C GRIN2D	1.37e-04	8	51	2	CID000125556
Drug	Phenanthrenes	GRIN2C GRIN2D	1.75e-04	9	51	2	ctd:D010616
Drug	imipramine	HTR6 AOC2 SMPD1 GRIN2C GRIN2D	1.79e-04	235	51	5	CID000003696
Drug	1c88	GRIN2C GRIN2D HR NOD2	1.83e-04	126	51	4	CID000444766
Drug	M100907	HTR6 GRIN2C GRIN2D	2.04e-04	51	51	3	CID000060858
Drug	piperidine	HTR6 GRIN2C GRIN2D NOD2	2.06e-04	130	51	4	CID000008082
Disease	developmental disorder of mental health (implicated_via_orthology)	GRIN2C GRIN2D SRCAP	8.98e-05	49	52	3	DOID:0060037 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WHELGHARPPVPGQC	HTR6	166	P50406
FPHGPKPGSSHRPWQ	NT5C2	266	P49902
WAPAEAHPLSPQGHP	SMPD1	56	P17405
PAAHSPWACGPPHWG	ASB16-AS1	36	Q495Z4
LQPSPSFCLHHPWPD	DISP1	141	Q96F81
SHHDTWPPACPPLEP	QSOX1	156	O00391
WAVHPPAPAHPSLLD	IQCN	31	Q9H0B3
HCPSVSHRAQPWPHP	AOC2	36	O75106
QPCPPAHWGPNCIHT	MEGF10	701	Q96KG7
QAGHTPRPHPWGCPA	PRSS12	81	P56730
PLLRPPAHLHFFPHW	GPR137C	111	Q8N3F9
GRCHSAAWTAPPVPP	HERC1	4351	Q15751
LHHGPLCLGEPAPFW	HR	36	O43593
SPPGAALPHPHLLWR	OR2W5P	206	A6NFC9
HGPPRCSAAWKPPQL	KCNH4	796	Q9UQ05
PDIHPIGWCDVTGHP	L3MBTL4	346	Q8NA19
PHQGPWGAPSPQAHL	FAM83A	371	Q86UY5
WGAPSPQAHLSPRPH	FAM83A	376	Q86UY5
HPHPNTCPRLPACWL	KLLN	136	B2CW77
PFHPRVHWAAPPSLS	PANK2	6	Q9BZ23
PPTWPPGPAHHSCHQ	NR1D1	366	P20393
PGQAPCPGIHHTEWA	GASK1A	406	Q9UFP1
RKYSAPSHWCPPDPH	GSTT4	76	A0A1W2PR19
PSHWCPPDPHARARV	GSTT4	81	A0A1W2PR19
LHHPSPDHFWPRFPD	EXT1	46	Q16394
WAPPTPRHSRCPPNH	B3GNT4	66	Q9C0J1
HPWQGRCPPIPAHGK	LINC00315	46	P59091
AWGHPCEMCPAQPHP	FBN1	216	P35555
WPIPAPPGCLRSHQH	GAB4	206	Q2WGN9
HKLPPAPAWHHFPPR	AXIN1	436	O15169
ASPFPPHHPALDSAW	ARX	416	Q96QS3
LGAPHPPPRDHLIWS	IFITM5	26	A6NNB3
RPPVHQGHPSPRCAW	HES7	161	Q9BYE0
QVGSEPPCHPGHSWR	CROCCP3	201	Q8IVE0
PPCHPGHSWRKKSAP	CROCCP3	206	Q8IVE0
PRCPHCNDYWPHEIP	NSMCE1	226	Q8WV22
RWAVSGHPHPGPDPN	CWH43	221	Q9H720
LCGHTWGLPHAPPSP	SZT2	1346	Q5T011
WPWRPATPRHPHPCL	NTN5	196	Q8WTR8
ACHPAAWSRGPAPPL	PRR36	1156	Q9H6K5
HACHPPPWLAPRQAA	SRCAP	1991	Q6ZRS2
WRLLHGPHGPACAHP	B3GNT9	376	Q6UX72
GHPAPSPIWRHAALG	CLEC12B	31	Q2HXU8
PTPHPHPHALGPRAW	SEMA6B	721	Q9H3T3
GPRAWDHGHPLLPAS	SEMA6B	731	Q9H3T3
SPKLHGCWDPHSLHP	NOD2	116	Q9HC29
AHLWTHAPTRPYPCP	ZNF575	136	Q86XF7
VPGHPSHWSDPPPIC	SEZ6	881	Q53EL9
PHHRPQPRSVPGWDS	VEGFB	141	P49765
HDGAPPKAPPNGHWR	TTC28	2421	Q96AY4
RSGWHHGPPAVLPPL	HIVEP2	1116	P31629
PAPSWPIHGPVIHSA	TUT4	1501	Q5TAX3
PWEHAPRPHFPLVPA	TUT4	1581	Q5TAX3
APWPKPGCASPHGSH	UNQ6493/PRO21345	101	Q6UXR8
PGCASPHGSHWPSIL	UNQ6493/PRO21345	106	Q6UXR8
HPRLCLQWHPEPPLA	ZAN	2636	Q9Y493
KSLCPDTWPHWHGPP	MYO1H	646	Q8N1T3
HLPFCWGAVCPHLPP	GRIN2C	1156	Q14957
WGAVCPHLPPCASHG	GRIN2C	1161	Q14957
PHLPPCASHGSWLSG	GRIN2C	1166	Q14957
RCPHAAHWGPPLPTA	GRIN2D	1296	O15399