Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of skin epidermis	KRT81 KRT83 KRT84 KRT85 KRT86	6.52e-06	43	123	5	GO:0030280
GeneOntologyMolecularFunction	RNA polymerase III cis-regulatory region sequence-specific DNA binding	GTF3C5 MTOR SNAPC4	7.84e-06	7	123	3	GO:0000992
GeneOntologyMolecularFunction	RNA polymerase III transcription regulatory region sequence-specific DNA binding	GTF3C5 MTOR SNAPC4	1.25e-05	8	123	3	GO:0001016
GeneOntologyMolecularFunction	RNA polymerase III general transcription initiation factor activity	GTF3C5 GTF3C3 SNAPC4	6.24e-05	13	123	3	GO:0000995
GeneOntologyMolecularFunction	5S rDNA binding	GTF3C5 MTOR	1.12e-04	3	123	2	GO:0080084
GeneOntologyMolecularFunction	RNA polymerase III type 2 promoter sequence-specific DNA binding	GTF3C5 MTOR	1.12e-04	3	123	2	GO:0001003
GeneOntologyMolecularFunction	RNA polymerase III type 1 promoter sequence-specific DNA binding	GTF3C5 MTOR	1.12e-04	3	123	2	GO:0001002
GeneOntologyMolecularFunction	protein serine kinase activity	HIPK3 CAMKK2 LATS2 MTOR ULK4 ATM PRKG1 MAP2K5 ULK2	4.19e-04	363	123	9	GO:0106310
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	HJV HIPK3 CAMKK2 LATS2 MTOR ULK4 ATM PRKG1 MAP2K5 ULK2	4.43e-04	446	123	10	GO:0004674
GeneOntologyMolecularFunction	RNA polymerase III type 3 promoter sequence-specific DNA binding	MTOR SNAPC4	5.55e-04	6	123	2	GO:0001006
GeneOntologyMolecularFunction	chromo shadow domain binding	ATRX NIPBL	5.55e-04	6	123	2	GO:0070087
GeneOntologyMolecularFunction	protein kinase activity	HJV IRAK2 HIPK3 CAMKK2 LATS2 MTOR ULK4 ATM PRKG1 MAP2K5 ULK2	1.21e-03	600	123	11	GO:0004672
GeneOntologyBiologicalProcess	intermediate filament organization	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	1.18e-08	75	119	8	GO:0045109
GeneOntologyBiologicalProcess	intermediate filament cytoskeleton organization	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	1.07e-07	99	119	8	GO:0045104
GeneOntologyBiologicalProcess	intermediate filament-based process	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	1.16e-07	100	119	8	GO:0045103
GeneOntologyBiologicalProcess	skin development	KRT9 KRT14 KRT17 KRT81 ENPP1 KRT83 KRT84 KRT85 KRT86 DICER1 LATS2 SOS1	1.71e-06	373	119	12	GO:0043588
GeneOntologyBiologicalProcess	keratinization	KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	1.12e-05	87	119	6	GO:0031424
GeneOntologyBiologicalProcess	keratinocyte differentiation	KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86 LATS2	1.41e-05	189	119	8	GO:0030216
GeneOntologyBiologicalProcess	multicellular organism growth	OTOA ATRX ENPP1 DICER1 KMT2C MTOR ATM NIPBL SOS1	1.44e-05	249	119	9	GO:0035264
GeneOntologyBiologicalProcess	molting cycle	KRT14 KRT17 KRT83 KRT84 DICER1 NIPBL SOS1	2.65e-05	150	119	7	GO:0042303
GeneOntologyBiologicalProcess	hair cycle	KRT14 KRT17 KRT83 KRT84 DICER1 NIPBL SOS1	2.65e-05	150	119	7	GO:0042633
GeneOntologyBiologicalProcess	transcription by RNA polymerase III	POLR2E GTF3C5 GTF3C3 MTOR SNAPC4	3.16e-05	63	119	5	GO:0006383
GeneOntologyBiologicalProcess	tRNA transcription by RNA polymerase III	POLR2E GTF3C5 GTF3C3	3.97e-05	12	119	3	GO:0042797
GeneOntologyBiologicalProcess	tRNA transcription	POLR2E GTF3C5 GTF3C3	5.13e-05	13	119	3	GO:0009304
GeneOntologyBiologicalProcess	epidermis development	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86 DICER1 LATS2 SOS1	7.44e-05	461	119	11	GO:0008544
GeneOntologyBiologicalProcess	post-embryonic forelimb morphogenesis	ATRX ENPP1	9.86e-05	3	119	2	GO:0035128
GeneOntologyBiologicalProcess	post-embryonic development	ATRX SZT2 ENPP1 DICER1 MTOR ATM	1.33e-04	135	119	6	GO:0009791
GeneOntologyBiologicalProcess	rRNA transcription	POLR2E GTF3C5 GTF3C3 MTOR	1.43e-04	46	119	4	GO:0009303
GeneOntologyBiologicalProcess	oligodendrocyte differentiation	ENPP1 DICER1 PTPRJ MTOR ULK4 EXOC4	1.44e-04	137	119	6	GO:0048709
GeneOntologyBiologicalProcess	developmental growth	OTOA ATRX ENPP1 SPG11 NCAPG2 DICER1 KMT2C SLC39A12 LATS2 MTOR ATM PRKG1 ULK2 NIPBL SOS1	2.40e-04	911	119	15	GO:0048589
GeneOntologyBiologicalProcess	epidermal cell differentiation	KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86 LATS2	2.45e-04	284	119	8	GO:0009913
GeneOntologyBiologicalProcess	growth	OTOA KRT17 ATRX ENPP1 SPG11 NCAPG2 DICER1 KMT2C SLC39A12 LATS2 PTPRJ MTOR ATM PRKG1 MAP2K5 ULK2 NIPBL SOS1	2.51e-04	1235	119	18	GO:0040007
GeneOntologyBiologicalProcess	post-embryonic limb morphogenesis	ATRX ENPP1	3.26e-04	5	119	2	GO:0035127
GeneOntologyBiologicalProcess	post-embryonic appendage morphogenesis	ATRX ENPP1	3.26e-04	5	119	2	GO:0035120
GeneOntologyBiologicalProcess	DNA repair	RNASEH2B ATRX RTEL1 USP44 MLH3 ABRAXAS1 KLHL15 TERB1 ATM ASCC3 NIPBL VCPIP1	3.70e-04	648	119	12	GO:0006281
GeneOntologyBiologicalProcess	walking behavior	KLHL1 ENPP1 SPG11 ULK4	4.00e-04	60	119	4	GO:0090659
GeneOntologyCellularComponent	keratin filament	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	1.00e-07	97	122	8	GO:0045095
GeneOntologyCellularComponent	intermediate filament	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	5.69e-05	227	122	8	GO:0005882
GeneOntologyCellularComponent	polymeric cytoskeletal fiber	KRT9 KRT14 KRT17 EFCAB6 KRT81 KRT83 KRT84 KRT85 KRT86 LRRC49 ARFGEF2 HOOK3 KIF15 DNAI2 CEP57 MX2	6.90e-05	899	122	16	GO:0099513
GeneOntologyCellularComponent	intermediate filament cytoskeleton	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	1.58e-04	263	122	8	GO:0045111
GeneOntologyCellularComponent	integrator complex	INTS13 INTS15 NIPBL	2.39e-04	21	122	3	GO:0032039
GeneOntologyCellularComponent	supramolecular fiber	CAB39 KRT9 KRT14 KRT17 EFCAB6 KRT81 KRT83 KRT84 KRT85 KRT86 LRRC49 ARFGEF2 HOOK3 KIF15 DNAI2 CEP57 MX2	4.95e-04	1179	122	17	GO:0099512
GeneOntologyCellularComponent	transcription factor TFIIIC complex	GTF3C5 GTF3C3	4.99e-04	6	122	2	GO:0000127
GeneOntologyCellularComponent	supramolecular polymer	CAB39 KRT9 KRT14 KRT17 EFCAB6 KRT81 KRT83 KRT84 KRT85 KRT86 LRRC49 ARFGEF2 HOOK3 KIF15 DNAI2 CEP57 MX2	5.34e-04	1187	122	17	GO:0099081
GeneOntologyCellularComponent	RNA polymerase III transcription regulator complex	GTF3C5 GTF3C3	1.18e-03	9	122	2	GO:0090576
HumanPheno	Perifollicular hyperkeratosis	KRT81 KRT83 KRT86	5.00e-06	4	56	3	HP:0007468
HumanPheno	Abnormal perifollicular morphology	KRT81 KRT83 KRT86	2.46e-05	6	56	3	HP:0031285
HumanPheno	Palmoplantar hyperkeratosis	KRT9 KRT14 KRT17 RTEL1 ENPP1 KRT83 KRT85 AP1B1	6.96e-05	129	56	8	HP:0000972
HumanPheno	Palmar hyperkeratosis	KRT9 KRT14 KRT17 RTEL1 ENPP1 KRT83 KRT85 AP1B1	7.76e-05	131	56	8	HP:0010765
HumanPheno	Plantar hyperkeratosis	KRT9 KRT14 KRT17 RTEL1 ENPP1 KRT83 KRT85 AP1B1	8.20e-05	132	56	8	HP:0007556
HumanPheno	Abnormality of the plantar skin of foot	KRT9 KRT14 KRT17 RTEL1 ENPP1 KRT83 KRT85 AP1B1 MTOR	8.53e-05	171	56	9	HP:0100872
MousePheno	abnormal cell nucleus morphology	KRT17 RTEL1 USP44 LATS2 ABRAXAS1 ATM CEP57 NIPBL VCPIP1	5.61e-06	184	98	9	MP:0003111
MousePheno	abnormal chromosome morphology	RTEL1 USP44 LATS2 ATM CEP57 NIPBL VCPIP1	2.87e-05	126	98	7	MP:0003702
Domain	ARM-type_fold	IPO5 CAB39 IPO8 IPO7 ARMC3 UBR4 MROH5 ARFGEF2 PSMD1 NCAPG2 AP1B1 AP2B1 MTOR LTN1 TERB1 ULK4 ATM NIPBL TARBP1	6.49e-13	339	121	19	IPR016024
Domain	ARM-like	IPO5 CAB39 IPO8 IPO7 ARMC3 MROH5 ARFGEF2 PSMD1 NCAPG2 AP1B1 AP2B1 MTOR LTN1 TERB1 ULK4 NIPBL TARBP1	1.83e-12	270	121	17	IPR011989
Domain	-	IPO5 CAB39 IPO8 IPO7 ARMC3 MROH5 ARFGEF2 PSMD1 NCAPG2 AP1B1 AP2B1 MTOR TERB1 ULK4 NIPBL	1.48e-11	222	121	15	1.25.10.10
Domain	Intermediate_filament_CS	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	7.06e-09	63	121	8	IPR018039
Domain	Filament	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	1.86e-08	71	121	8	SM01391
Domain	IF	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	2.08e-08	72	121	8	PS00226
Domain	Filament	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	2.32e-08	73	121	8	PF00038
Domain	IF	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	3.21e-08	76	121	8	IPR001664
Domain	Keratin_2_head	KRT81 KRT83 KRT84 KRT85 KRT86	4.04e-07	24	121	5	IPR032444
Domain	Keratin_2_head	KRT81 KRT83 KRT84 KRT85 KRT86	4.04e-07	24	121	5	PF16208
Domain	Keratin_II	KRT81 KRT83 KRT84 KRT85 KRT86	6.20e-07	26	121	5	IPR003054
Domain	Clathrin_b-adaptin_app_Ig-like	AP1B1 AP2B1	4.16e-05	2	121	2	IPR013037
Domain	-	AP1B1 AP2B1	4.16e-05	2	121	2	2.60.40.1150
Domain	HEAT_REPEAT	IPO5 NCAPG2 MTOR ULK4 NIPBL	9.08e-05	70	121	5	PS50077
Domain	IMPORTIN_B_NT	IPO5 IPO8 IPO7	9.16e-05	14	121	3	PS50166
Domain	AP_complex_bsu_1_2_4	AP1B1 AP2B1	1.24e-04	3	121	2	IPR016342
Domain	Cse1	IPO8 IPO7	1.24e-04	3	121	2	PF08506
Domain	Cse1	IPO8 IPO7	1.24e-04	3	121	2	IPR013713
Domain	B2-adapt-app_C	AP1B1 AP2B1	1.24e-04	3	121	2	PF09066
Domain	Importin-beta_N	IPO5 IPO8 IPO7	1.69e-04	17	121	3	IPR001494
Domain	Keratin_I	KRT9 KRT14 KRT17 KRT84	1.86e-04	44	121	4	IPR002957
Domain	B2-adapt-app_C	AP1B1 AP2B1	2.48e-04	4	121	2	SM01020
Domain	B-adaptin_app_sub_C	AP1B1 AP2B1	2.48e-04	4	121	2	IPR015151
Domain	AP_beta	AP1B1 AP2B1	4.11e-04	5	121	2	IPR026739
Domain	FATC	MTOR ATM	4.11e-04	5	121	2	PF02260
Domain	HEAT	IPO5 NCAPG2 MTOR NIPBL	5.43e-04	58	121	4	IPR000357
Domain	FAT	MTOR ATM	6.14e-04	6	121	2	PS51189
Domain	FATC	MTOR ATM	6.14e-04	6	121	2	PS51190
Domain	FAT	MTOR ATM	6.14e-04	6	121	2	PF02259
Domain	PIK-rel_kinase_FAT	MTOR ATM	6.14e-04	6	121	2	IPR003151
Domain	FATC_dom	MTOR ATM	6.14e-04	6	121	2	IPR003152
Domain	PIK_FAT	MTOR ATM	6.14e-04	6	121	2	IPR014009
Domain	Beta2_adaptin/TBP_C_dom	AP1B1 AP2B1	6.14e-04	6	121	2	IPR012295
Domain	FATC	MTOR ATM	6.14e-04	6	121	2	SM01343
Domain	-	AP1B1 AP2B1	6.14e-04	6	121	2	3.30.310.10
Domain	Kinase-like_dom	IRAK2 HIPK3 CAMKK2 LATS2 MTOR ULK4 ATM PRKG1 MAP2K5 ULK2 SOS1	7.98e-04	542	121	11	IPR011009
Domain	Coatomer/calthrin_app_sub_C	AP1B1 AP2B1	1.14e-03	8	121	2	IPR009028
Domain	Alpha_adaptinC2	AP1B1 AP2B1	1.45e-03	9	121	2	PF02883
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP1B1 AP2B1	1.45e-03	9	121	2	IPR008152
Domain	Alpha_adaptinC2	AP1B1 AP2B1	1.45e-03	9	121	2	SM00809
Domain	ARM	ARMC3 AP1B1 AP2B1	2.20e-03	40	121	3	SM00185
Domain	PROTEIN_KINASE_ST	IRAK2 HIPK3 CAMKK2 LATS2 ULK4 PRKG1 MAP2K5 ULK2	2.48e-03	362	121	8	PS00108
Domain	Coatomer/clathrin_app_Ig-like	AP1B1 AP2B1	2.63e-03	12	121	2	IPR013041
Domain	Pkinase	IRAK2 HIPK3 CAMKK2 LATS2 ULK4 PRKG1 MAP2K5 ULK2	3.39e-03	381	121	8	PF00069
Domain	Armadillo	ARMC3 AP1B1 AP2B1	3.49e-03	47	121	3	IPR000225
Domain	Clathrin/coatomer_adapt-like_N	AP1B1 AP2B1	4.14e-03	15	121	2	IPR002553
Domain	PI3/4_kinase_CS	MTOR ATM	4.14e-03	15	121	2	IPR018936
Domain	Adaptin_N	AP1B1 AP2B1	4.14e-03	15	121	2	PF01602
Domain	IBN_N	IPO8 IPO7	4.14e-03	15	121	2	PF03810
Domain	-	MTOR ATM	4.71e-03	16	121	2	1.10.1070.11
Domain	IBN_N	IPO8 IPO7	4.71e-03	16	121	2	SM00913
Domain	PI3Kc	MTOR ATM	4.71e-03	16	121	2	SM00146
Domain	PI3_PI4_kinase	MTOR ATM	5.95e-03	18	121	2	PF00454
Domain	PI3_4_KINASE_1	MTOR ATM	5.95e-03	18	121	2	PS00915
Domain	PI3_4_KINASE_2	MTOR ATM	5.95e-03	18	121	2	PS00916
Domain	PI3/4_kinase_cat_dom	MTOR ATM	5.95e-03	18	121	2	IPR000403
Domain	PI3_4_KINASE_3	MTOR ATM	5.95e-03	18	121	2	PS50290
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	7.13e-08	87	89	8	MM15351
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	1.50e-06	129	89	8	M27649
Pathway	REACTOME_KERATINIZATION	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	5.38e-06	153	89	8	MM15343
Pathway	REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION	POLR2E GTF3C5 GTF3C3 SNAPC4	5.96e-05	34	89	4	MM15435
Pathway	REACTOME_KERATINIZATION	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	6.71e-05	217	89	8	M27640
Pathway	REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION	POLR2E GTF3C5 GTF3C3 SNAPC4	1.26e-04	41	89	4	M739
Pubmed	New consensus nomenclature for mammalian keratins.	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	6.40e-11	63	123	8	16831889
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86 UBR4 AP1B1 AP2B1 SOS1	2.12e-10	266	123	12	19380743
Pubmed	Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain.	KRT81 KRT83 KRT84 KRT85 KRT86	3.96e-10	12	123	5	10692104
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	IPO5 IPO8 IPO7 KRT86 NCAPG2 AP2B1 MTOR LTN1 EXOC4 SOS1	1.14e-09	183	123	10	23956138
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	IPO5 CUL2 KIAA0930 IPO7 KRT17 KRT81 KRT84 KRT85 POLR2E USP25 PSMD1 DICER1 USP44 AP2B1 ABRAXAS1 KLHL15 ASCC3 TARBP1 VCPIP1	2.75e-09	1005	123	19	19615732
Pubmed	Novel KRT83 and KRT86 mutations associated with monilethrix.	KRT81 KRT83 KRT86	4.32e-08	3	123	3	25557232
Pubmed	Structure and site of expression of a murine type II hair keratin.	KRT81 KRT83 KRT86	4.32e-08	3	123	3	1372089
Pubmed	Transient expression of mouse hair keratins in transfected HeLa cells: interactions between "hard" and "soft" keratins.	KRT81 KRT83 KRT86	4.32e-08	3	123	3	1712823
Pubmed	Sequences and differential expression of three novel human type-II hair keratins.	KRT83 KRT85 KRT86	4.32e-08	3	123	3	9084137
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	IPO5 KRT9 KRT14 IPO7 ARFGEF2 DICER1 MTOR LTN1 ASCC3	4.68e-08	202	123	9	33005030
Pubmed	Defining the membrane proteome of NK cells.	IPO5 ACAP1 KRT9 IPO7 LSG1 UBR4 ARFGEF2 PSMD1 ERGIC2 CCDC77 NCAPG2 KIF15 AP2B1 MTOR ENTPD1 EXOC2 ASCC3 EXOC4	1.63e-07	1168	123	18	19946888
Pubmed	Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle.	KRT14 KRT81 KRT86	1.72e-07	4	123	3	9457912
Pubmed	Keratins of the human hair follicle.	KRT81 KRT83 KRT86	1.72e-07	4	123	3	15797458
Pubmed	ATM binds to beta-adaptin in cytoplasmic vesicles.	AP1B1 AP2B1 ATM	1.72e-07	4	123	3	9707615
Pubmed	Hague (Hag). A new mouse hair mutation with an unstable semidominant allele.	KRT81 KRT84 KRT85 KRT86	2.62e-07	16	123	4	12399393
Pubmed	Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis.	KRT14 KRT81 KRT85 KRT86	5.54e-07	19	123	4	27234308
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	IPO5 CUL2 TBC1D9B IPO8 IPO7 PPFIBP1 UBR4 POLR2E PSMD1 NCAPG2 DICER1 HOOK3 AP2B1 MTOR LTN1 ATM EXOC2 ASCC3 EXOC4	7.59e-07	1440	123	19	30833792
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	IPO5 CUL2 IPO7 PSMD1 GTF3C5 THOC5 AP1B1 AP2B1 INTS13 LTN1 EXOC2 EXOC4	7.69e-07	560	123	12	35241646
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KRT14 KRT17 ATRX ARMC3 LSG1 KRT84 UBR4 SANBR PSMD1 SPG11 CCDC77 TNRC18 LATS2 AP2B1 ATM PLCH1 DTHD1 CEP57 NIPBL	7.74e-07	1442	123	19	35575683
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	GCFC2 IPO8 PPFIBP1 UBR4 PSMD1 CCDC77 THOC5 WTAP KMT2C TNRC18 INTS15 POC5 TARBP1	1.08e-06	689	123	13	36543142
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CUL2 IPO8 IPO7 ATRX LSG1 PPFIBP1 UBR4 SPG11 FASTKD2 CCDC77 NCAPG2 DICER1 GTF3C3 THOC5 CAMKK2 ATM ASCC3 PLCH1 EXOC4	1.22e-06	1487	123	19	33957083
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	ATRX RTEL1 CCDC77 NCAPG2 MLH3 AP1B1 AP2B1 NIPBL	1.33e-06	222	123	8	37071664
Pubmed	Functional proteomics mapping of a human signaling pathway.	ATRX KRT81 UBR4 USP25 ARFGEF2 PSMD1 EPG5 HIPK3 RLF AP1B1 ASCC3 VCPIP1	1.35e-06	591	123	12	15231748
Pubmed	Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.	IPO5 IPO8 IPO7	1.50e-06	7	123	3	11682607
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	ARFGEF2 NCAPG2 LTN1 ATM EXOC2 TARBP1	1.98e-06	104	123	6	31240132
Pubmed	Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.	IPO5 IPO8 IPO7	2.39e-06	8	123	3	27114554
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	IPO8 MTOR ATM EXOC2	2.45e-06	27	123	4	23027611
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	LRRC49 UBR4 PSMD1 GTF3C5 GTF3C3 RLF KIF15 ASCC3 EXOC4 VCPIP1	2.53e-06	418	123	10	34709266
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	IPO5 IPO8 IPO7 UBR4 PSMD1 GTF3C5 GTF3C3 AP1B1 AP2B1 MTOR ASCC3 EXOC4	2.96e-06	638	123	12	33239621
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	IPO5 ATRX PPFIBP1 KRT83 UBR4 USP25 ARFGEF2 PSMD1 AP2B1 SH3D19 ATM RAPGEF2 NIPBL TARBP1 EXOC4 VCPIP1 SOS1	2.97e-06	1285	123	17	35914814
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CUL2 SAMD9 ATRX LSG1 ENPP1 PPFIBP1 ERGIC2 NCAPG2 DICER1 AP1B1 PLCH1 EXOC4	3.58e-06	650	123	12	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IPO5 IPO7 UBR4 PSMD1 DICER1 GTF3C3 AP1B1 AP2B1 MTOR ATM ASCC3 NIPBL	3.75e-06	653	123	12	22586326
Pubmed	Network organization of the human autophagy system.	IPO5 CUL2 CAB39 ENPP1 KRT85 GTF3C3 CAMKK2 MTOR SNAPC4 ULK2	3.75e-06	437	123	10	20562859
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	IPO5 RNASEH2B CUL2 IPO7 KRT17 UBR4 POLR2E USP25 ARFGEF2 PSMD1 NIF3L1 UNC13D KIF15 AP1B1 AP2B1 MTOR INTS13 VCPIP1	3.77e-06	1455	123	18	22863883
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	IPO8 ATRX SZT2 LSG1 POTEG HIPK3 SLC39A12 AP1B1 ENTPD1 ULK4 IL17RD	4.53e-06	552	123	11	10737800
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	IPO5 CUL2 KRT9 KRT14 IPO7 PSMD1 NCAPG2 AP1B1 AP2B1 INTS13	4.95e-06	451	123	10	36168627
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	TBC1D9B IPO7 UBR4 POLR2E PSMD1 NCAPG2 GTF3C3 AP1B1 MTOR B3GNT2 ASCC3 TARBP1 EXOC4 VCPIP1	6.52e-06	942	123	14	31073040
Pubmed	Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.	KRT9 KRT14 KRT17 RTEL1 KRT83 KRT85 SOS1	6.86e-06	197	123	7	23686814
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	IPO5 IPO7 ATRX ARFGEF2 PSMD1 AP1B1 INTS13 ATM EXOC2 NIPBL EXOC4	7.46e-06	582	123	11	20467437
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	CUL2 UBR4 USP25 PSMD1 ERGIC2 KIF15 AP2B1 ABRAXAS1 ASCC3 VCPIP1	8.69e-06	481	123	10	28190767
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	CAB39 TBC1D9B UBR4 ARFGEF2 GTF3C5 GTF3C3 AP1B1 MTOR	9.07e-06	288	123	8	23383273
Pubmed	LncRNA DUXAP9-206 directly binds with Cbl-b to augment EGFR signaling and promotes non-small cell lung cancer progression.	SAMD9 ULK4 ULK2	9.28e-06	12	123	3	30515972
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	IPO5 CUL2 IPO8 IPO7 UBR4 PSMD1 NCAPG2 DICER1 AP1B1 AP2B1 MTOR LTN1 ASCC3 VCPIP1	9.49e-06	974	123	14	28675297
Pubmed	A human MAP kinase interactome.	KRT14 KRT17 PSMD1 HIPK3 KMT2C AP2B1 SH3D19 RAPGEF2 MAP2K5 SOS1	9.50e-06	486	123	10	20936779
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	KRT9 KRT14 SAMD9 IPO7 KRT17 LSG1 PPFIBP1 KRT84 KRT85 POLR2E GTF3C5 GTF3C3 THOC5 WTAP AP2B1 ASCC3	9.65e-06	1257	123	16	36526897
Pubmed	Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.	CUL2 KRT9 KRT14 KRT17 KRT81 KRT84 KRT85 KRT86 AP2B1 EXOC4	9.85e-06	488	123	10	31324722
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	IPO5 KRT9 KRT14 IPO7 KRT17 LSG1 PPFIBP1 KRT85 UBR4 POLR2E PSMD1 AP1B1 AP2B1 EXOC2 NIPBL TARBP1 VCPIP1	1.05e-05	1415	123	17	28515276
Pubmed	BerEp4, cytokeratin 14, and cytokeratin 17 immunohistochemical staining aid in differentiation of basaloid squamous cell carcinoma from basal cell carcinoma with squamous metaplasia.	KRT14 KRT17	1.24e-05	2	123	2	24168496
Pubmed	A missense mutation in the type II hair keratin hHb3 is associated with monilethrix.	KRT83 KRT86	1.24e-05	2	123	2	15744029
Pubmed	Protein-altering germline mutations implicate novel genes related to lung cancer development.	KIAA0930 ATM	1.24e-05	2	123	2	32393777
Pubmed	Loss of ATRX suppresses ATM dependent DNA damage repair by modulating H3K9me3 to enhance temozolomide sensitivity in glioma.	ATRX ATM	1.24e-05	2	123	2	29378238
Pubmed	Three cDNA sequences of mouse type I keratins. Cellular localization of the mRNAs in normal and hyperproliferative tissues.	KRT14 KRT17	1.24e-05	2	123	2	2433272
Pubmed	A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1.	KRT81 KRT86	1.24e-05	2	123	2	9665406
Pubmed	An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.	THOC5 ATM	1.24e-05	2	123	2	21937706
Pubmed	A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix.	KRT81 KRT86	1.24e-05	2	123	2	9402962
Pubmed	Saikosaponin-d inhibits proliferation by up-regulating autophagy via the CaMKKβ-AMPK-mTOR pathway in ADPKD cells.	CAMKK2 MTOR	1.24e-05	2	123	2	29675630
Pubmed	Regulation of canonical transient receptor potential isoform 3 (TRPC3) channel by protein kinase G.	TRPC3 PRKG1	1.24e-05	2	123	2	14983059
Pubmed	E-NTPDase and E-ADA activities are altered in lymphocytes of patients with indeterminate form of Chagas' disease.	ENPP1 ENTPD1	1.24e-05	2	123	2	22846899
Pubmed	Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin.	KRT14 KRT17	1.24e-05	2	123	2	20871598
Pubmed	Screening diagnostic biomarkers of OSCC via an LCM-based proteomic approach.	KRT14 KRT17	1.24e-05	2	123	2	30066921
Pubmed	NPP1 is responsible for potent extracellular ATP hydrolysis as NTPDase1 in primary cultured murine microglia.	ENPP1 ENTPD1	1.24e-05	2	123	2	29516286
Pubmed	Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.	IPO5 KRT9 KRT14 KRT17 UBR4	1.26e-05	84	123	5	29563501
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	HJV IPO5 RNASEH2B CAB39 ATRX SZT2 UBR4 UNC13D SPG11 NCAPG2 DICER1 RLF KMT2C ULK2 NIPBL SOS1	1.88e-05	1327	123	16	32694731
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	TBC1D9B IPO8 IPO7 UBR4 POLR2E PSMD1 AP1B1 MTOR LTN1 MX2 EXOC4	1.99e-05	647	123	11	26618866
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	GCFC2 ATRX ARFGEF2 PSMD1 WTAP FAM13A ATM EXOC2 SNAPC4 NIPBL VCPIP1 SOS1	2.05e-05	774	123	12	15302935
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	CAB39 ATRX PPFIBP1 POLR2E DICER1 HIPK3 CAMKK2 LATS2 AP1B1 AP2B1 PRKG1 MAP2K5 SOS1	2.15e-05	910	123	13	36736316
Pubmed	DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.	KRT9 KRT14 KRT17 KRT83 KRT84 KRT85 AP2B1	2.33e-05	238	123	7	35864588
Pubmed	Comprehensive analysis of keratin gene clusters in humans and rodents.	KRT81 KRT83 KRT86	2.34e-05	16	123	3	15085952
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	IPO7 LSG1 UBR4 POLR2E PSMD1 FASTKD2 NCAPG2 GTF3C5 GTF3C3 RLF AP2B1 LTN1 EXOC2 ASCC3 NIPBL EXOC4	2.38e-05	1353	123	16	29467282
Pubmed	Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.	KRT9 KRT81 KRT83 KRT85 KRT86	2.41e-05	96	123	5	23580065
Pubmed	Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.	IPO5 IPO7 GTF3C5 KMT2C	2.57e-05	48	123	4	27703004
Pubmed	Dlx3 is a crucial regulator of hair follicle differentiation and cycling.	KRT14 KRT17 KRT85	3.39e-05	18	123	3	18684741
Pubmed	Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β).	CAMKK2 MTOR	3.71e-05	3	123	2	23027865
Pubmed	Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production.	DICER1 TARBP1	3.71e-05	3	123	2	17360756
Pubmed	Immunohistochemical staining patterns of cytokeratins 13, 14, and 17 in oral epithelial dysplasia including orthokeratotic dysplasia.	KRT14 KRT17	3.71e-05	3	123	2	24471966
Pubmed	Characterization of the TRBP domain required for dicer interaction and function in RNA interference.	DICER1 TARBP1	3.71e-05	3	123	2	19422693
Pubmed	Protein kinase C can inhibit TRPC3 channels indirectly via stimulating protein kinase G.	TRPC3 PRKG1	3.71e-05	3	123	2	16331690
Pubmed	Ileal neuroendocrine tumors show elevated activation of mammalian target of rapamycin complex.	ATRX MTOR	3.71e-05	3	123	2	25439321
Pubmed	Sequence data and chromosomal localization of human type I and type II hair keratin genes.	KRT81 KRT86	3.71e-05	3	123	2	7556444
Pubmed	ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis.	MTOR ATM	3.71e-05	3	123	2	22362778
Pubmed	Preferential utilization of Imp7/8 in nuclear import of Smads.	IPO8 IPO7	3.71e-05	3	123	2	18519565
Pubmed	Keratin 16 expression defines a subset of epithelial cells during skin morphogenesis and the hair cycle.	KRT14 KRT17	3.71e-05	3	123	2	12445204
Pubmed	Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling.	MTOR ATM	3.71e-05	3	123	2	21641396
Pubmed	ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.	MTOR ATM	3.71e-05	3	123	2	20160076
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KIAA0930 TBC1D9B SZT2 UBR4 ARFGEF2 PCNX2 KMT2C TNRC18 LATS2 MTOR ULK4 SNAPC4 IL17RD ULK2	3.81e-05	1105	123	14	35748872
Pubmed	PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.	KRT81 KRT83 KRT86	4.01e-05	19	123	3	21285247
Pubmed	Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.	KRT14 KRT17 KRT84 KRT86 THOC5	4.06e-05	107	123	5	32989256
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	CUL2 UBR4 USP25 ERGIC2 NCAPG2 GTF3C3 AP2B1 ABRAXAS1 ASCC3 MAP2K5	6.00e-05	604	123	10	38803224
Pubmed	C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.	IPO5 IPO8 IPO7 PSMD1 AP1B1	6.75e-05	119	123	5	35776542
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIAA0930 TBC1D9B RTEL1 PPFIBP1 THOC5 TNRC18 LTN1 PLCH1 EXOC4	6.78e-05	493	123	9	15368895
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	KRT14 KRT17 KRT81 KRT83 KRT85 KRT86 VCPIP1	7.13e-05	284	123	7	29459677
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	IPO5 KRT14 IPO7 KRT17 KRT84 KRT86 POLR2E PSMD1 DICER1 GTF3C5 HOOK3 ASCC3 NIPBL	7.17e-05	1024	123	13	24711643
Pubmed	An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation.	EXOC2 EXOC4	7.41e-05	4	123	2	19885391
Pubmed	Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.	EXOC2 EXOC4	7.41e-05	4	123	2	26350970
Pubmed	Transcriptional activation of a subset of hair keratin genes by the NF-kappaB effector p65/RelA.	KRT81 KRT85	7.41e-05	4	123	2	18021261
Pubmed	The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone.	TRPC3 PRKG1	7.41e-05	4	123	2	23832809
Pubmed	Elevated HMGN4 expression potentiates thyroid tumorigenesis.	ATRX ATM	7.41e-05	4	123	2	28186538
Pubmed	ZER1 Contributes to the Carcinogenic Activity of High-Risk HPV E7 Proteins.	CUL2 UBR4	7.41e-05	4	123	2	36346242
Pubmed	Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex.	EXOC2 EXOC4	7.41e-05	4	123	2	20579884
Pubmed	Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism.	AP1B1 AP2B1	7.41e-05	4	123	2	7534311
Interaction	GPR17 interactions	TBC1D9B IPO8 PPFIBP1 ARFGEF2 SPG11 HOOK3 MTOR LTN1 ATM EXOC2 TARBP1 EXOC4	1.53e-07	283	122	12	int:GPR17
Interaction	COMTD1 interactions	CAB39 TBC1D9B IPO8 IPO7 PPFIBP1 NCAPG2 HOOK3 MTOR EXOC2 EXOC4	3.89e-07	200	122	10	int:COMTD1
Interaction	P2RY6 interactions	IPO5 TBC1D9B IPO8 IPO7 UBR4 POLR2E PSMD1 DICER1 PTPRJ MTOR LTN1 EXOC2 EXOC4	6.19e-07	385	122	13	int:P2RY6
Interaction	KRT19 interactions	KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86 CCDC77 HOOK3 KIF15 EXOC4	1.18e-06	282	122	11	int:KRT19
Interaction	FPR1 interactions	TBC1D9B IPO8 ARFGEF2 SPG11 ERGIC2 MTOR ATM EXOC2	3.16e-06	147	122	8	int:FPR1
Interaction	KRT16 interactions	CUL2 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86 ARFGEF2 WTAP	3.20e-06	197	122	9	int:KRT16
Interaction	KRT27 interactions	CUL2 KRT17 KRT81 KRT83 KRT85 KRT86 HOOK3 CCBE1 EXOC4	3.92e-06	202	122	9	int:KRT27
Interaction	LRRC31 interactions	IPO5 KRT9 KRT14 IPO7 ARFGEF2 DICER1 MTOR LTN1 ASCC3	4.43e-06	205	122	9	int:LRRC31
Interaction	CFTR interactions	IPO5 CUL2 KRT9 TBC1D9B KRT14 IPO8 IPO7 KRT17 KRT81 KRT84 KRT85 KRT86 UBR4 POLR2E PSMD1 FASTKD2 AP1B1 AP2B1 MTOR ABRAXAS1 LTN1 PRKG1 MX2 EXOC4	7.69e-06	1480	122	24	int:CFTR
Interaction	TNFSF13B interactions	IPO8 IPO7 PPFIBP1 NCAPG2 HOOK3 MTOR EXOC2	8.01e-06	119	122	7	int:TNFSF13B
Interaction	OFD1 interactions	IPO5 KRT81 KRT83 KRT86 POLR2E CCDC77 LATS2 AP2B1 POC5 SNAPC4 EXOC4	8.61e-06	347	122	11	int:OFD1
Interaction	KRT76 interactions	CUL2 KRT14 KRT17 KRT84 KRT86 TSGA10	1.20e-05	84	122	6	int:KRT76
Interaction	PCM1 interactions	IPO5 KRT14 KRT81 KRT83 KRT86 LRRC49 CCDC77 HOOK3 LATS2 KIF15 POC5 EXOC4	1.31e-05	434	122	12	int:PCM1
Interaction	EFNA4 interactions	KRT9 KRT14 KRT17 KRT83 KRT85 NR6A1 ATM TARBP1 SOS1	1.52e-05	239	122	9	int:EFNA4
Interaction	IQCB1 interactions	CAB39 KRT9 KRT14 IPO7 KRT17 ARFGEF2 IRAK2 LATS2 LTN1 SNAPC4 EXOC4	1.57e-05	370	122	11	int:IQCB1
Interaction	TRIM52 interactions	CUL2 RTEL1 NCAPG2 GTF3C3 HOOK3 ASCC3 SNAPC4	1.66e-05	133	122	7	int:TRIM52
Interaction	GPR182 interactions	IPO8 ARFGEF2 SPG11 ERGIC2 ACY1 NCAPG2 MTOR LTN1 ATM EXOC2 TARBP1 EXOC4	2.09e-05	455	122	12	int:GPR182
Interaction	KRT14 interactions	CUL2 KRT14 KRT17 KRT81 KRT84 KRT85 KRT86 WTAP	2.24e-05	192	122	8	int:KRT14
Interaction	VIM interactions	TBC1D9B KRT14 GCFC2 KRT17 KRT84 UBR4 TSGA10 PSMD1 NIF3L1 THOC5 WTAP CAMKK2 KIF15 B3GNT2 ASCC3 MAP2K5	2.81e-05	804	122	16	int:VIM
Interaction	KRT37 interactions	KRT81 KRT83 KRT85 KRT86 HOOK3 VCPIP1	3.26e-05	100	122	6	int:KRT37
Interaction	SLX4 interactions	IPO8 IPO7 ATRX RTEL1 CCDC77 NCAPG2 GTF3C5 GTF3C3 MLH3 AP1B1 AP2B1 ASCC3 NIPBL	4.40e-05	572	122	13	int:SLX4
Interaction	DUXAP9 interactions	SAMD9 ULK4 ULK2	4.58e-05	12	122	3	int:DUXAP9
Interaction	VCP interactions	IPO5 CUL2 CAB39 KRT9 TBC1D9B KRT14 IPO7 KRT17 ATRX KRT81 PPFIBP1 UBR4 ARFGEF2 PSMD1 DICER1 GTF3C5 GTF3C3 AP1B1 AP2B1 MTOR ANXA10 VCPIP1	4.61e-05	1435	122	22	int:VCP
Interaction	NPTN interactions	GCFC2 IPO8 ARFGEF2 SPG11 MTOR LTN1 ATM EXOC2 TARBP1	4.98e-05	278	122	9	int:NPTN
Interaction	MTMR4 interactions	CUL2 NCAPG2 HIPK3 HOOK3 AP1B1 AP2B1 EXOC4	5.02e-05	158	122	7	int:MTMR4
Interaction	KRT25 interactions	KRT81 KRT83 KRT85 KRT86	5.79e-05	35	122	4	int:KRT25
Interaction	EPS15 interactions	KRT9 KRT14 KRT17 KRT83 KRT85 KRT86 AP1B1 AP2B1	5.89e-05	220	122	8	int:EPS15
Interaction	SIGLECL1 interactions	TBC1D9B IPO8 IPO7 ARFGEF2 AP1B1 LTN1	6.48e-05	113	122	6	int:SIGLECL1
Interaction	KRT13 interactions	CUL2 KRT17 KRT81 KRT85 HOOK3 CEP57	7.50e-05	116	122	6	int:KRT13
Interaction	KRT8 interactions	KRT14 IPO8 KRT17 LSG1 KRT84 LRRC49 UBR4 CCDC77 KIF15 LTN1 CEP57	7.72e-05	441	122	11	int:KRT8
Interaction	KRT36 interactions	KRT81 KRT83 KRT85 KRT86 CCBE1	8.64e-05	74	122	5	int:KRT36
Interaction	ZUP1 interactions	IPO5 KRT9 KRT14 KRT17 SZT2 UBR4 MTOR	9.22e-05	174	122	7	int:ZUP1
Interaction	KRT15 interactions	KRT81 KRT83 KRT84 KRT85 KRT86 NIF3L1 CEP57	1.06e-04	178	122	7	int:KRT15
Interaction	GRB2 interactions	ACAP1 KRT9 KRT14 KRT17 KRT81 KRT83 KRT85 KRT86 UBR4 NIF3L1 HIPK3 PTPRJ AP2B1 SH3D19 SOS1	1.08e-04	806	122	15	int:GRB2
Interaction	DUSP2 interactions	IPO5 UBR4 DICER1 LTN1 ASCC3	1.33e-04	81	122	5	int:DUSP2
Interaction	CIB2 interactions	RTEL1 GTF3C5 GTF3C3 B3GNT2 ASCC3	1.33e-04	81	122	5	int:CIB2
Interaction	PNKD interactions	IPO8 IPO7 PPFIBP1 NR6A1 DICER1 AP1B1	1.53e-04	132	122	6	int:PNKD
Interaction	CDX2 interactions	IPO8 IPO7 ATRX THOC5 ATM	1.76e-04	86	122	5	int:CDX2
Interaction	SQSTM1 interactions	IPO5 CUL2 IPO7 ENPP1 NIF3L1 FASTKD2 CCDC77 GTF3C3 AP2B1 MTOR B3GNT2 DNAI2 ULK4 ASCC3 RAPGEF2 MAP2K5 ULK2 NIPBL EXOC4	1.95e-04	1257	122	19	int:SQSTM1
Interaction	LEFTY1 interactions	WTAP MTOR	2.16e-04	4	122	2	int:LEFTY1
Interaction	IMPDH2 interactions	IPO5 CUL2 LRRC49 UBR4 PSMD1 KIF15 INTS13 SH3D19 ASCC3 EXOC4	2.40e-04	420	122	10	int:IMPDH2
Interaction	TPGS2 interactions	LRRC49 UBR4 LTN1	2.66e-04	21	122	3	int:TPGS2
Interaction	KIR2DL4 interactions	TBC1D9B IPO8 IPO7 LTN1 EXOC2	2.67e-04	94	122	5	int:KIR2DL4
Interaction	CTDP1 interactions	POLR2E ARFGEF2 NCAPG2 LTN1 ATM EXOC2 TARBP1	2.69e-04	207	122	7	int:CTDP1
Interaction	OPALIN interactions	IPO8 ARFGEF2 NCAPG2 MTOR LTN1 ATM TARBP1	2.85e-04	209	122	7	int:OPALIN
Interaction	IFFO1 interactions	ACAP1 KRT81 KRT86 LATS2	3.20e-04	54	122	4	int:IFFO1
Interaction	NICN1 interactions	LRRC49 SANBR LTN1	3.51e-04	23	122	3	int:NICN1
Interaction	H3C1 interactions	IPO5 RNASEH2B ATRX CDIN1 UBR4 GTF3C5 GTF3C3 RLF KMT2C TNRC18 PIEZO2 AP2B1 ATM NIPBL TARBP1	3.59e-04	901	122	15	int:H3C1
Interaction	SSX2IP interactions	IPO8 IPO7 LRRC49 NIF3L1 HOOK3 LATS2 POC5 VCPIP1	3.72e-04	288	122	8	int:SSX2IP
Interaction	C9orf78 interactions	IPO5 CUL2 IPO7 PSMD1 GTF3C5 THOC5 AP1B1 AP2B1 INTS13 LTN1 EXOC2 EXOC4	3.85e-04	620	122	12	int:C9orf78
Interaction	UBC interactions	CUL2 UBR4 USP25 PSMD1 USP44 KIF15 AP2B1 ABRAXAS1 ASCC3 VCPIP1	3.86e-04	446	122	10	int:UBC
Interaction	SASS6 interactions	RTEL1 KRT83 LRRC49 UBR4 CCDC77 TARBP1	4.18e-04	159	122	6	int:SASS6
Interaction	HTR6 interactions	IPO8 MTOR ATM EXOC2	4.21e-04	58	122	4	int:HTR6
Interaction	KRT6A interactions	CUL2 KRT14 KRT17 KRT84 TSGA10 WTAP	4.32e-04	160	122	6	int:KRT6A
Interaction	KRT39 interactions	KRT81 KRT83 KRT85 KRT86	4.50e-04	59	122	4	int:KRT39
Interaction	BSG interactions	IPO5 GCFC2 IPO8 IPO7 ARFGEF2 NCAPG2 AP2B1 MTOR ATM EXOC2 TARBP1 EXOC4	4.51e-04	631	122	12	int:BSG
Interaction	CEP128 interactions	IPO8 LRRC49 CCDC77 LATS2 AP2B1 POC5 ASCC3 EXOC4	4.57e-04	297	122	8	int:CEP128
Interaction	GPR45 interactions	TBC1D9B IPO8 SPG11 ERGIC2 NCAPG2 MTOR ATM EXOC2	4.88e-04	300	122	8	int:GPR45
Cytoband	12q13	KRT81 KRT83 KRT84 KRT85 KRT86	1.44e-06	71	123	5	12q13
Cytoband	Ensembl 112 genes in cytogenetic band chr12p11	IPO8 PPFIBP1 ERGIC2 INTS13	8.40e-05	85	123	4	chr12p11
GeneFamily	Keratins, type II	KRT81 KRT83 KRT84 KRT85 KRT86	8.62e-08	27	76	5	609
GeneFamily	X-linked mental retardation\|RNA helicases	ATRX DICER1 ASCC3	1.15e-05	11	76	3	1168
GeneFamily	Armadillo repeat containing\|Importins	IPO5 IPO8 IPO7	5.57e-05	18	76	3	596
GeneFamily	Keratins, type I	KRT9 KRT14 KRT17	2.17e-04	28	76	3	608
GeneFamily	Exocyst complex	EXOC2 EXOC4	6.16e-04	9	76	2	1055
GeneFamily	DNA helicases	RTEL1 ASCC3	2.28e-03	17	76	2	1167
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	GCFC2 IPO8 IPO7 ATRX RTEL1 LRRC49 SANBR TSGA10 ARFGEF2 CCDC77 DICER1 HOOK3 KIF15 INTS13 CCBE1 ABRAXAS1 ATM RAPGEF2 CEP57 NIPBL SOS1	5.37e-06	1257	118	21	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1	CAB39 IPO7 EFCAB6 ATRX CDIN1 USP25 FASTKD2 RLF KIF15 RAPGEF2 CEP57 NIPBL	1.20e-05	469	118	12	Facebase_RNAseq_e8.5_Floor Plate_2500_K1
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500	GCFC2 IPO8 IPO7 ATRX RTEL1 LRRC49 SANBR TSGA10 ARFGEF2 CCDC77 DICER1 HOOK3 KIF15 INTS13 CCBE1 ABRAXAS1 ATM RAPGEF2 CEP57 NIPBL SOS1	4.99e-05	1459	118	21	facebase_RNAseq_e10.5_Emin_LatNas_2500
ToppCell	droplet-Tongue-nan-24m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT81 ENPP1 KRT83 KRT84 KRT85 KRT86 CAMKK2	1.64e-08	104	123	7	a4ae3cae44aac8b6e0d14896f9acab44f0cc97c4
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PPFIBP1 TRPC3 PIEZO2 FAM13A CCBE1 SH3D19 PRKG1	9.06e-07	187	123	7	a9316e2818217ec5feae9cf8816f7249803caee6
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	EFCAB6 ARMC3 TSGA10 DNAI2 ULK4 PLCH1 DTHD1	1.12e-06	193	123	7	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACAP1 KRT81 ENPP1 KRT83 KRT86 UNC13D ENTPD1	1.12e-06	193	123	7	afdf92ecace145407d57192dde5d0dac0bc37ee9
ToppCell	NS-critical-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	EFCAB6 ARMC3 LRRC49 DYDC2 DNAI2 PLCH1 DTHD1	1.16e-06	194	123	7	1ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFCAB6 ARMC3 SANBR TSGA10 DNAI2 ULK4 DTHD1	1.16e-06	194	123	7	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	control-Neutrophil\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	KIAA0930 UBR4 HIPK3 TNRC18 CAMKK2 FAM13A ENTPD1	1.42e-06	200	123	7	b5d197472799cc61d7497faed91ac2564ae4930a
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Lymphocytic-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GCFC2 RTEL1 TRPC3 UNC13D ULK4 PRKG1	6.62e-06	165	123	6	475905d608fac628960188ae4a18010b8097417e
ToppCell	droplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT14 KRT17 ENPP1 ACY1 CCBE1 ANXA10	6.62e-06	165	123	6	622aca1d49bd8c917b131e4f4959d9dba411d22b
ToppCell	droplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT14 KRT17 ENPP1 ACY1 CCBE1 ANXA10	7.09e-06	167	123	6	3c06894fc6177f3c204094719904da42f08b9af8
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFCAB6 ARMC3 LRRC9 DNAI2 ULK4 DTHD1	7.59e-06	169	123	6	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Otx2_(ventral_lateral_geniculate_nucleus,_magnocellular_part_(VLGMC)?)--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	DNHD1 MROH5 KIF15 CCBE1 TERB1	1.09e-05	105	123	5	c7528276fee8f6d2cb4639069bc87413b0288025
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Otx2_(ventral_lateral_geniculate_nucleus,_magnocellular_part_(VLGMC)?)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	DNHD1 MROH5 KIF15 CCBE1 TERB1	1.09e-05	105	123	5	7bcf3345a21a1ade717128be127e9fe12ae40011
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Otx2_(ventral_lateral_geniculate_nucleus,_magnocellular_part_(VLGMC)?)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	DNHD1 MROH5 KIF15 CCBE1 TERB1	1.09e-05	105	123	5	62e89b92bb8c5187ab0205aebd018b4178710bb0
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACAP1 KRT81 ENPP1 KRT86 UNC13D ENTPD1	1.35e-05	187	123	6	42b20d7f0a4f9195b3d71dc0e089b5e0914ebcbb
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	EPG5 RLF KMT2C FAM13A RAPGEF2 NIPBL	1.39e-05	188	123	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-keratinocyte\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT14 KRT17 KRT81 KRT84 KRT85 KRT86	1.43e-05	189	123	6	7ee9b00a8bd46f2da9218623bb2617b2e585f9d5
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	EFCAB6 ARMC3 DNAI2 ULK4 PLCH1 DTHD1	1.43e-05	189	123	6	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAB39 ATRX UBR4 ITGA9 PIEZO2 ENTPD1	1.57e-05	192	123	6	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	NR6A1 PTPRJ PRKG1 RAPGEF2 EXOC4 SOS1	1.76e-05	196	123	6	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFCAB6 SANBR TSGA10 LRRC9 ULK4 DTHD1	1.81e-05	197	123	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	systemic_lupus_erythematosus-treated\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ACAP1 SAMD9 ATRX ERGIC2 ATM MX2	1.87e-05	198	123	6	8165ff735095c52994fb5057d89be93cc378b7da
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	USP25 KMT2C PTPRJ RAPGEF2 EXOC4 SOS1	1.92e-05	199	123	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	EFCAB6 ARMC3 ADCY2 DYDC2 LRRC9 DTHD1	1.97e-05	200	123	6	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	LPS_IL1RA-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	EFCAB6 ARMC3 ADCY2 DYDC2 DNAI2 DTHD1	1.97e-05	200	123	6	4992dbf0514d674017315dbd20d91dfec0c608e9
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SAMD9 ATRX KMT2C ATM NIPBL MX2	1.97e-05	200	123	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	(08)_PNEC-(2)_48hpi\|(08)_PNEC / shred by cell type and Timepoint	KRT17 ENPP1 PPFIBP1 PCNX2 INTS15	4.68e-05	142	123	5	e95d34170f5053678e0dd9793e68d93c03b05822
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-valve_cells\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HJV ENPP1 AIPL1 PRKG1 DTHD1	6.66e-05	153	123	5	1440f2716fea74e2c3eb2924eba3d63ebd08c997
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells-Ciliated\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARMC3 ADCY2 DYDC2 LRRC9 DTHD1	6.87e-05	154	123	5	9ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARMC3 ADCY2 DYDC2 LRRC9 DTHD1	6.87e-05	154	123	5	58072ce422d09f2de602580325eaac6c4ec6c136
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARMC3 ADCY2 DYDC2 LRRC9 DTHD1	7.09e-05	155	123	5	5f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARMC3 ADCY2 DYDC2 LRRC9 DTHD1	7.09e-05	155	123	5	0944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell	390C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DNHD1 C8orf48 MLH3 PTPRJ SOS1	8.73e-05	162	123	5	45be019b50e3727fc9d3fad2ff78e74e4f2d746b
ToppCell	390C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DNHD1 C8orf48 MLH3 PTPRJ SOS1	8.73e-05	162	123	5	fbb0cc2b1434a340dc35058b77c73ea61004c252
ToppCell	390C-Lymphocytic-ILC\|390C / Donor, Lineage, Cell class and subclass (all cells)	ENPP1 KRT85 KRT86 INTS13 SOS1	9.25e-05	164	123	5	b0fc63b72162b5cc4d1e0a271a12f3d3ab29398f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SAMD9 KLHL1 ENPP1 CCBE1 MX2	9.52e-05	165	123	5	7978eefcfc40175e933f7a8b64a5dd1c661dd1ac
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-ILC3\|GI_small-bowel / Manually curated celltypes from each tissue	ENPP1 KRT83 KRT86 LATS2 PRKG1	9.79e-05	166	123	5	773673a5d0430640439845b264740bfbbdad0cb2
ToppCell	Ionocyte-iono-3\|World / Class top	DNHD1 RTEL1 ENTPD1 POC5 PLCH1	9.79e-05	166	123	5	9c4a780f8af46d7552077c7a0ae0ab1b2413e5d4
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like\|GI_small-bowel / Manually curated celltypes from each tissue	ENPP1 KRT83 KRT86 LATS2 PRKG1	1.01e-04	167	123	5	3ae46c6363da76c8e1f5579e6027bf88ed637a44
ToppCell	10x5'-Lung-Lymphocytic_T_CD4/8-lo-Trm_Tgd\|Lung / Manually curated celltypes from each tissue	DNHD1 KRT81 KRT86 SH3D19 TARBP1	1.01e-04	167	123	5	dcbcc658082910838c8082d71a64917055086cc4
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	GTF3C3 CCDC7 KIF15 SNAPC4 ULK2	1.04e-04	168	123	5	8697b40b2ec2cce68ef3beb4792eb3eff29be053
ToppCell	3'_v3-Lung-Myeloid_Mac-Intestinal_macrophages\|Lung / Manually curated celltypes from each tissue	ITGA9 ADCY2 AP1B1 ENTPD1 PLCH1	1.06e-04	169	123	5	241644823e6f949aaf4c671d4579721d7ef6b0e5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KLHL1 CDIN1 ITGA9 KIF15 SLC13A5	1.13e-04	171	123	5	c2dbc439af28d4fabb24d57685b75b2e588819b0
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT14 KRT17 ENPP1 NR6A1 IL17RD	1.13e-04	171	123	5	121e63ca281ad765d76c2afb3b4d441329b47f81
ToppCell	T_cells-CD56_bright_CD16-_NK_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	KRT81 KRT86 IRAK2 AIPL1 PRKG1	1.16e-04	172	123	5	980e8b9e1ceeb0dec9eb9ef95c139e5ffe99b6e4
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SAMD9 KRT17 ENPP1 C8orf48 CCBE1	1.22e-04	174	123	5	912a9e892b29d945666fc37c986009c97c668ac8
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ARMC3 DYDC2 DNAI2 ULK4 PLCH1	1.22e-04	174	123	5	f41d05a3703d7092bd3c4a97c15ae13069aaa4ad
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ENPP1 KRT86 IRAK2 UNC13D B3GNT2	1.22e-04	174	123	5	c0204a0d0a979a489e8d30dc5396e99da14c119c
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ARMC3 DYDC2 DNAI2 ULK4 PLCH1	1.25e-04	175	123	5	c01a15b2084da4a18f8ff3623f44eb9dfe499f10
ToppCell	LPS-IL1RA+antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA9 FAM13A CCBE1 SH3D19 EXOC4	1.32e-04	177	123	5	b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IPO5 GTF3C3 INTS13 PLCH1 MX2	1.32e-04	177	123	5	2dd6dd5193bda9ba1c6b299ec47890fdc92f88b1
ToppCell	droplet-Limb_Muscle-nan-21m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR6A1 MTOR DNAI2 ULK4 EXOC2	1.32e-04	177	123	5	291231b1520c135e92739e201495fe1935efa927
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_C\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RTEL1 ENPP1 PPFIBP1 KRT86 LATS2	1.36e-04	178	123	5	50bb1f2c6a8d050ff2af217fd76c3b1b7b4a4a69
ToppCell	FF-Differ-KC\|World / shred by cell class for mouse tongue	KRT81 KRT83 KRT84 KRT85 KRT86	1.39e-04	179	123	5	1526a130565a97c291a25a7a988089bffc1515c1
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACAP1 KRT81 KRT83 KRT86 USP44	1.43e-04	180	123	5	ca7c316027e31559103b2cab1a2c0de993e42e95
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-T_cells\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACAP1 KRT81 KRT83 KRT86 USP44	1.43e-04	180	123	5	eb26ba86fba26899e54c448afc25382ddc853013
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-NK_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACAP1 KRT81 KRT83 KRT86 DTHD1	1.51e-04	182	123	5	feda21c92d30848de70c8b404eaabbca3f5e894d
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPC3 KIF15 KLHL15 DNAI2 PRKG1	1.51e-04	182	123	5	c84f44391932080df31c8765e363c3dff64b2bd1
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACAP1 KRT81 ENPP1 KRT83 KRT86	1.54e-04	183	123	5	d4a558bc0b8e11be195a7da1468ab38eb477117d
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA EFCAB6 PIEZO2 CCBE1 PLCH1	1.58e-04	184	123	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	343B-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TBC1D9B USP25 EPG5 ULK2 VCPIP1	1.58e-04	184	123	5	2c2125b8030af83f7a6d59a7102d4de8e0ac1988
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA EFCAB6 PIEZO2 CCBE1 PLCH1	1.58e-04	184	123	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA EFCAB6 PIEZO2 CCBE1 PLCH1	1.58e-04	184	123	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ACAP1 SAMD9 ERGIC2 FAM13A ATM	1.63e-04	185	123	5	406b52516b26e9fe2c9e768950af447ec7ad5f3e
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	EFCAB6 ARMC3 LRRC49 DYDC2 DNAI2	1.63e-04	185	123	5	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ACAP1 SAMD9 ERGIC2 FAM13A ATM	1.63e-04	185	123	5	f2ebd099c8dfcfaca4298bcdd618c50701a9c2c8
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACAP1 KRT81 KRT83 KRT86 UNC13D	1.63e-04	185	123	5	e1fd66f4295056807aa29c0e4ce6b1a79cc8dfcf
ToppCell	Ciliated_cells-B-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	EFCAB6 ARMC3 DYDC2 DNAI2 DTHD1	1.67e-04	186	123	5	f72267d533fd0c5280d9741ceee3dd116300a7e4
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	PIEZO2 CCBE1 SH3D19 ULK4 PRKG1	1.71e-04	187	123	5	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ITGA9 PTPRJ PRKG1 PLCH1 IL17RD	1.71e-04	187	123	5	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-T_cells-gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACAP1 KRT81 KRT83 KRT86 ENTPD1	1.80e-04	189	123	5	5c85656f555d91ecc9540faa67717694a4aef92f
ToppCell	droplet-Tongue-nan-3m-Epithelial-filiform\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT81 KRT83 KRT84 KRT85 KRT86	1.84e-04	190	123	5	251e3a33041023bfc4b547c7eb68cfb8f421636f
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACAP1 KRT81 ENPP1 KRT83 KRT86	1.84e-04	190	123	5	af39d2a46d9502cec69a69b7e8ffef78fc8311c3
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EFCAB6 ARMC3 DYDC2 DNAI2 DTHD1	1.88e-04	191	123	5	e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EFCAB6 ARMC3 DYDC2 DNAI2 DTHD1	1.88e-04	191	123	5	9d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EFCAB6 ARMC3 DYDC2 DNAI2 DTHD1	1.88e-04	191	123	5	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	droplet-Tongue-Unstain-18m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT14 KRT17 KRT81 KRT84 KRT86	1.93e-04	192	123	5	45ff9555f9a9fccc650885956005b2e5b4820a56
ToppCell	droplet-Tongue-Unstain\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT14 KRT17 KRT81 KRT84 KRT86	1.93e-04	192	123	5	0f0fae7e1177609eff82fa4452042306297a7103
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3\|lymph-node_spleen / Manually curated celltypes from each tissue	KRT81 ENPP1 KRT86 LRRC49 PRKG1	1.93e-04	192	123	5	e16035b3328f9b1b2e28d234c62ba88387540550
ToppCell	droplet-Tongue-Unstain-18m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT14 KRT17 KRT81 KRT84 KRT86	1.93e-04	192	123	5	b198e42a962c4e24ea9faad867ca1255316a5d99
ToppCell	IPF-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	ARMC3 DYDC2 DNAI2 PLCH1 DTHD1	1.93e-04	192	123	5	d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRJ SH3D19 PRKG1 RAPGEF2 EXOC4	1.93e-04	192	123	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	EFCAB6 ARMC3 DNAI2 ULK4 DTHD1	1.98e-04	193	123	5	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PIEZO2 CCBE1 SH3D19 ULK4 PRKG1	1.98e-04	193	123	5	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	T_cells-CD56_bright_CD16-_NK_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	KRT81 ENPP1 PPFIBP1 KRT86 PRKG1	1.98e-04	193	123	5	826457e2aafdb61ead8a0a44d8cf9088d310684b
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PIEZO2 LATS2 CCBE1 SH3D19 PRKG1	1.98e-04	193	123	5	cf3cbf79ccd34ddcf06ec6194a18a7afd7f91f39
ToppCell	ASK440-Epithelial-Ciliated\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	ARMC3 TSGA10 DYDC2 DNAI2 DTHD1	1.98e-04	193	123	5	a0baa8be6f590b2031fede22be588715ae458e93
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PPFIBP1 TRPC3 PIEZO2 CCBE1 PRKG1	2.03e-04	194	123	5	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	IPO5 KRT81 KRT86 UBR4 NCAPG2	2.03e-04	194	123	5	5031f324628ff12a33e84cc52157be4786e0961d
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADCY2 PIEZO2 CCBE1 SH3D19 PRKG1	2.03e-04	194	123	5	99577a5a631e607b5abe7a1b0d8d6a5eabe50196
ToppCell	Control-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	ARMC3 DYDC2 DNAI2 PLCH1 DTHD1	2.03e-04	194	123	5	958e648138676d46698090b4046cb484083ae449
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TRPC3 PIEZO2 CCBE1 SH3D19 PRKG1	2.03e-04	194	123	5	a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADCY2 PIEZO2 CCBE1 SH3D19 PRKG1	2.07e-04	195	123	5	70387a62f121f8c374dba1aca9ab65cfed6a0b10
ToppCell	IPF-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	PPFIBP1 NR6A1 ITGA9 PIEZO2 PRKG1	2.07e-04	195	123	5	de88e9d22044b4b3e29676ad02b3e9299cc920ad
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PPFIBP1 TRPC3 PIEZO2 CCBE1 PRKG1	2.07e-04	195	123	5	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	Control_saline-Epithelial_airway-airway_epithelial-Ciliated\|Control_saline / Treatment groups by lineage, cell group, cell type	ARMC3 ADCY2 LRRC9 DNAI2 DTHD1	2.07e-04	195	123	5	60067b5359174f0d1a8b5748bfc0690762e9e740
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADCY2 PIEZO2 CCBE1 ENTPD1 PRKG1	2.07e-04	195	123	5	f5e91ce20a7ce528dc4c1a968c7bf096bf45c528
ToppCell	Severe-NK\|Severe / Disease group and Cell class	SAMD9 KRT81 KRT86 LATS2 MX2	2.12e-04	196	123	5	66130d38b67e51e2385de8a89227759fd137999c
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	IPO5 ARFGEF2 AP1B1 ENTPD1 TARBP1	2.12e-04	196	123	5	09d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCell	Severe-NK\|World / Disease group and Cell class	SAMD9 KRT81 KRT86 LATS2 MX2	2.18e-04	197	123	5	1e5fb79385657a467c2d9f942d8cafb8ef7826c9
Computational	Genes in the cancer module 68.	KRT14 KRT17 KRT85 KRT86	2.09e-05	26	69	4	MODULE_68
Computational	Keratin.	KRT14 KRT17 KRT85 KRT86	2.09e-05	26	69	4	MODULE_298
Drug	al-Badry	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86 POLR2E	2.88e-07	165	123	9	CID000004545
Drug	teleocidin B	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	3.54e-07	123	123	8	CID000072425
Drug	sulfur mustard	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	5.40e-07	130	123	8	CID000010461
Drug	homocysteine thiolactone	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	5.73e-07	131	123	8	CID000107712
Drug	pyriproxyfen	HJV KRT81 KRT83 KRT86	6.63e-06	23	123	4	CID000091753
Drug	AC1L9MJT	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86	9.95e-06	192	123	8	CID000448959
Drug	Buflomedil hydrochloride [35543-24-9]; Up 200; 11.6uM; HL60; HT_HG-U133A	TSGA10 THOC5 CAMKK2 ENTPD1 DNAI2 SNAPC4 RAPGEF2 VCPIP1	1.16e-05	196	123	8	1338_UP
Drug	Pipemidic acid [51940-44-4]; Down 200; 13.2uM; HL60; HT_HG-U133A	ACAP1 FASTKD2 THOC5 HIPK3 AP1B1 MAP2K5 NIPBL VCPIP1	1.16e-05	196	123	8	3093_DN
Drug	S-(+)-ibuprofen [51146-56-6]; Down 200; 19.4uM; MCF7; HT_HG-U133A	KIAA0930 IPO8 RTEL1 ENTPD1 ATM PLCH1 MAP2K5 VCPIP1	1.16e-05	196	123	8	6471_DN
Drug	1-2q	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86 ATM	2.81e-05	289	123	9	CID000011820
Drug	melicopicine	KRT81 KRT83	2.89e-05	2	123	2	CID000101253
Drug	tebuquine	KRT81 KRT83	2.89e-05	2	123	2	CID000071991
Drug	3,5-di-O-galloylquinic acid	KRT81 KRT83	2.89e-05	2	123	2	CID000460896
Drug	Velcade (bortezomib	KRT9 KRT14 KRT17 KRT81 KRT83 KRT84 KRT85 KRT86 PSMD1 MTOR	3.67e-05	374	123	10	CID000093860
Drug	Metaproterenol sulfate, orciprenaline sulfate [5874-97-5]; Up 200; 7.6uM; HL60; HT_HG-U133A	RTEL1 PPFIBP1 HIPK3 FAM13A ENTPD1 DNAI2 MX2	4.72e-05	175	123	7	2485_UP
Drug	Hb 7	KRT81 KRT83 KRT85	5.36e-05	14	123	3	CID000128180
Drug	CP-9	KRT81 KRT83 SOS1	6.68e-05	15	123	3	CID000452634
Drug	Diphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A	IPO5 SAMD9 ATRX ATM RAPGEF2 CEP57 VCPIP1	8.19e-05	191	123	7	6020_DN
Drug	Astemizole [68844-77-9]; Down 200; 8.8uM; HL60; HG-U133A	KIAA0930 PSMD1 CAMKK2 AP2B1 ATM SNAPC4 RAPGEF2	8.47e-05	192	123	7	1365_DN
Drug	sulfonamide-3	KRT81 KRT83	8.65e-05	3	123	2	CID009847197
Drug	tulipanin	ITGA9 MTOR	8.65e-05	3	123	2	CID000192918
Drug	Tiaprofenic acid [33005-95-7]; Down 200; 15.4uM; MCF7; HT_HG-U133A	IPO5 SAMD9 ATRX KRT83 GTF3C5 MAP2K5 MX2	9.03e-05	194	123	7	4171_DN
Drug	Cyanocobalamin [68-19-9]; Down 200; 3uM; PC3; HT_HG-U133A	GTF3C5 THOC5 CAMKK2 B3GNT2 PLCH1 MAP2K5 SOS1	9.03e-05	194	123	7	4572_DN
Drug	Biperiden hydrochloride [1235-82-1]; Up 200; 11.4uM; MCF7; HT_HG-U133A	SAMD9 IPO8 KRT83 HIPK3 PRDM12 PLCH1 MAP2K5	9.33e-05	195	123	7	3321_UP
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; PC3; HT_HG-U133A	IPO5 SAMD9 RTEL1 ARFGEF2 GTF3C5 AP2B1 VCPIP1	9.63e-05	196	123	7	6559_UP
Drug	Chenodiol [474-25-9]; Up 200; 10.2uM; PC3; HT_HG-U133A	GCFC2 THOC5 HIPK3 ENTPD1 ATM SNAPC4 PLCH1	9.63e-05	196	123	7	7310_UP
Drug	Chloroquine diphosphate [50-63-5]; Up 200; 7.8uM; PC3; HT_HG-U133A	RNASEH2B IPO8 SZT2 THOC5 B3GNT2 INTS15 ANXA10	9.63e-05	196	123	7	7251_UP
Drug	UTP-NA	ENPP1 POLR2E ADCY2 GTF3C5 GTF3C3 CAMKK2 ENTPD1 SNAPC4 PLCH1 MAP2K5	9.64e-05	420	123	10	CID000001181
Drug	CQ-S	KRT81 KRT83 B3GNT2	9.90e-05	17	123	3	CID000072462
Drug	Proadifen hydrochloride [62-68-0]; Down 200; 10.2uM; MCF7; HT_HG-U133A	CUL2 GTF3C5 HIPK3 CAMKK2 AP1B1 MAP2K5 VCPIP1	1.03e-04	198	123	7	3446_DN
Drug	Phentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; HL60; HT_HG-U133A	ACAP1 DICER1 MTOR INTS15 ATM MAP2K5 NIPBL	1.03e-04	198	123	7	2362_DN
Drug	Carbetapentane citrate [23142-01-0]; Down 200; 7.6uM; MCF7; HT_HG-U133A	ATRX ARFGEF2 PCNX2 MTOR B3GNT2 CEP57 NIPBL	1.03e-04	198	123	7	2623_DN
Drug	Ioxaglic acid [59017-64-0]; Up 200; 3.2uM; HL60; HT_HG-U133A	SZT2 RTEL1 TSGA10 FASTKD2 MLH3 FAM13A ENTPD1	1.06e-04	199	123	7	2966_UP
Drug	Antipyrine, 4-hydroxy [1672-63-5]; Up 200; 19.6uM; PC3; HG-U133A	IPO5 TBC1D9B RTEL1 ENPP1 MLH3 NIPBL TARBP1	1.06e-04	199	123	7	1915_UP
Drug	Drofenine hydrochloride [548-66-3]; Down 200; 11.4uM; PC3; HT_HG-U133A	TBC1D9B IPO8 PCNX2 AP2B1 B3GNT2 ANXA10 NIPBL	1.09e-04	200	123	7	7129_DN
Drug	Pentoxifylline [6493-05-6]; Up 200; 14.4uM; PC3; HT_HG-U133A	IPO5 KIAA0930 KRT9 TBC1D9B FASTKD2 PCNX2 MAP2K5	1.09e-04	200	123	7	2127_UP
Drug	ATBI	KRT81 KRT83 KRT86	1.18e-04	18	123	3	CID000505862
Disease	MONILETHRIX	KRT81 KRT83 KRT86	6.73e-08	3	121	3	158000
Disease	Beaded hair	KRT81 KRT83 KRT86	6.73e-08	3	121	3	cv:C0546966
Disease	monilethrix (is_implicated_in)	KRT81 KRT83 KRT86	6.73e-08	3	121	3	DOID:0050472 (is_implicated_in)
Disease	Monilethrix	KRT81 KRT83 KRT86	2.68e-07	4	121	3	C0546966
Disease	Malignant neoplasm of breast	NPBWR1 ACAP1 TBC1D9B KRT14 UBR4 ARFGEF2 ACY1 ITGA9 THOC5 EPG5 SLC39A12 HOOK3 MTOR ABRAXAS1 ATM NIPBL	8.44e-06	1074	121	16	C0006142
Disease	Intellectual Disability	RNASEH2B ACY1 GTF3C3 KMT2C AP1B1 MTOR CCBE1 KLHL15 ENTPD1 ASCC3	1.63e-05	447	121	10	C3714756
Disease	hair disease (is_implicated_in)	KRT81 KRT86	1.67e-05	2	121	2	DOID:421 (is_implicated_in)
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	MLH3 PTPRJ ATM	6.21e-05	19	121	3	C1333991
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	MLH3 PTPRJ ATM	6.21e-05	19	121	3	C2936783
Disease	cancer (implicated_via_orthology)	IPO5 CAB39 ACAP1 LATS2 MTOR ATM NIPBL	1.23e-04	268	121	7	DOID:162 (implicated_via_orthology)
Disease	aggressive behavior	SAMD9 ARFGEF2 HIPK3	1.45e-04	25	121	3	EFO_0003015
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	MLH3 PTPRJ ATM	1.63e-04	26	121	3	C0009405
Disease	Hereditary non-polyposis colorectal cancer syndrome	MLH3 PTPRJ ATM	1.83e-04	27	121	3	C1112155
Disease	lung small cell carcinoma (is_implicated_in)	ATRX MTOR ATM	2.04e-04	28	121	3	DOID:5409 (is_implicated_in)
Disease	Hereditary Nonpolyposis Colorectal Cancer	MLH3 PTPRJ ATM	2.27e-04	29	121	3	C1333990
Disease	female breast cancer (is_implicated_in)	RTEL1 ATM	4.59e-04	8	121	2	DOID:0050671 (is_implicated_in)
Disease	nevus count, cutaneous melanoma	KIAA0930 RTEL1 ATM MX2	5.46e-04	91	121	4	EFO_0000389, EFO_0004632
Disease	Adenoid Cystic Carcinoma	ATRX KMT2C ATM IL17RD	7.79e-04	100	121	4	C0010606
Disease	brain volume measurement	TBC1D9B SZT2 RTEL1 KRT86 LRRC49 SLC39A12 PTPRJ CCBE1 EXOC2	7.93e-04	595	121	9	EFO_0006930
Disease	Hamman-Rich syndrome	RTEL1 FAM13A	1.47e-03	14	121	2	C0085786
Disease	Kartagener syndrome (implicated_via_orthology)	AP1B1 DNAI2	1.47e-03	14	121	2	DOID:0050144 (implicated_via_orthology)
Disease	cutaneous melanoma	KIAA0930 RTEL1 ATM MX2	1.58e-03	121	121	4	EFO_0000389
Disease	colorectal cancer (is_implicated_in)	DICER1 MLH3 PTPRJ ATM	1.58e-03	121	121	4	DOID:9256 (is_implicated_in)
Disease	Adenocarcinoma of lung (disorder)	IPO5 IRAK2 LATS2 ATM SOS1	1.63e-03	206	121	5	C0152013
Disease	idiopathic pulmonary fibrosis	RTEL1 FAM13A KIF15	1.67e-03	57	121	3	EFO_0000768
Disease	Neoplasm of uncertain or unknown behavior of bladder	MTOR ATM	1.69e-03	15	121	2	C0496930
Disease	Benign neoplasm of bladder	MTOR ATM	1.69e-03	15	121	2	C0154017
Disease	Carcinoma in situ of bladder	MTOR ATM	1.69e-03	15	121	2	C0154091
Disease	Keratoderma, Palmoplantar	KRT9 KRT14	1.93e-03	16	121	2	C4551675
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	MTOR ATM	1.93e-03	16	121	2	C0334634
Disease	Carcinoma of bladder	MTOR ATM	2.44e-03	18	121	2	C0699885
Disease	ascending aortic diameter	UNC13D PIEZO2 ENTPD1 ULK4	2.69e-03	140	121	4	EFO_0021787
Disease	primary ciliary dyskinesia (implicated_via_orthology)	AP1B1 DNAI2	2.72e-03	19	121	2	DOID:9562 (implicated_via_orthology)
Disease	diet measurement, HOMA-B	KLHL1 PCNX2	2.72e-03	19	121	2	EFO_0004469, EFO_0008111
Disease	Usual Interstitial Pneumonia	RTEL1 FAM13A	2.72e-03	19	121	2	C4721509
Disease	Hamman-Rich Disease	RTEL1 FAM13A	2.72e-03	19	121	2	C4721508
Disease	Familial Idiopathic Pulmonary Fibrosis	RTEL1 FAM13A	3.02e-03	20	121	2	C4721952
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	DNHD1 ACY1 MTOR ATM	3.28e-03	148	121	4	C0279702
Disease	advanced glycosylation end product-specific receptor ligand measurement	OR14J1 FAM13A	3.33e-03	21	121	2	EFO_0010762
Disease	Idiopathic Pulmonary Fibrosis	RTEL1 FAM13A	3.33e-03	21	121	2	C1800706
Disease	hair colour measurement	KIAA0930 KRT17 KRT86 UNC13D NR6A1 EPG5 FAM13A EXOC2	3.91e-03	615	121	8	EFO_0007822
Disease	Immunologic Deficiency Syndromes	EPG5 ATM	3.99e-03	23	121	2	C0021051

Protein segments in the cluster

Peptide	Gene	Start	Entry
NEMYASLQEELKSIC	ABRAXAS1	216	Q6UWZ7
AFQLMQEDCIQKLLY	EPG5	1176	Q9HCE0
EKMINTLILNYCQCL	AIPL1	226	Q9NZN9
QMILCNKSYQQLRLV	ANXA10	196	Q9UJ72
NCMQTDNLELKKLVY	AP2B1	56	P63010
QVLLDAEYKQMQCDF	CCDC7	296	Q96M83
INIDITVAMKCQYVG	ERGIC2	76	Q96RQ1
EMFINAIKQYLCVAL	ARFGEF2	426	Q9Y6D5
AENKCNLLEKQLEYM	CEP57	136	Q86XR8
EKKLSNMYQEQCISL	CCDC77	356	Q9BR77
TVEYICTQQNILFML	CAB39	116	Q9Y376
KLMCELGNVIINQIY	ACAP1	471	Q15027
NCMQTDNLELKKLVY	AP1B1	56	Q10567
VKKNSMECIYNLVQD	ARMC3	166	Q5W041
YMICQSLISVLEEQI	DNHD1	526	Q96M86
QVLIMTCYVALNVLK	DICER1	146	Q9UPY3
IMEHCIKQNNAIDIY	DNAI2	116	Q9GZS0
NMQECIDQKVYQAEV	HJV	226	Q6ZVN8
LMQIQKCELVLIHTY	INTS13	196	Q9NVM9
VLNCQKTIYNLVDME	INTS13	491	Q9NVM9
ELQLLEIMCNYFQEQ	INTS15	71	Q96N11
VKVLCLNYNHIESIM	LRRC9	1141	Q6ZRR7
CEILQKMNITYDNLR	LTN1	1051	O94822
DEELNALQSYCTMKI	C8orf48	116	Q96LL4
DATVAQVLLYQMIKC	OTOA	356	Q7RTW8
VCIQISNDYEAKVAM	POC5	311	Q8NA72
NVYAIIMLTKCVEQG	PTPRJ	1131	Q12913
QAKQDMARQLCEYQE	KRT84	436	Q9NSB2
LIEDYRIKQQQQCAM	KMT2C	3261	Q8NEZ4
LFTVMCRKKQQENIY	IL17RD	316	Q8NFM7
ACLQDSYDNLQEIMK	KIF15	861	Q9NS87
CYVKEMDANKENVIL	LSG1	196	Q9H089
VENVMAKEICQKYLE	IRAK2	446	O43187
ECQNQEYSLLLSIKM	KRT9	431	P35527
LCEAEQEQMRKILYQ	LATS2	636	Q9NRM7
LNMDCIIAEIKAQYD	KRT85	286	P78386
QCLNRYKKMQDTVVL	PPFIBP1	331	Q86W92
TEMLKQEEYQIQQNC	DYDC2	71	Q96IM9
QLRCEMEQQNQEYKI	KRT14	386	P02533
NLELSQIQEIVDCMY	PRKG1	106	Q13976
QKAKQDMACLIREYQ	KRT86	376	O43790
LNLILQKLDYMVTCA	KIAA0930	106	Q6ICG6
ELYQQLNDLEACVMQ	IFNA1;	111	P01562
QINTFCTYLLEQIDM	PCNX2	971	A6NKB5
NIMQVFIYCLEQLST	EXOC2	661	Q96KP1
DDLTNVIQKMICEYS	IPO7	556	O95373
VLQQVDNKFIACLMS	MLH3	1191	Q9UHC1
QKQIMSELEILYKCD	MAP2K5	206	Q13163
QMLKLACSYEFINEI	OR14J1	181	Q9UGF5
YIQMVTALVLQLIQC	NIPBL	1486	Q6KC79
IEIRNKNSYMKLCLQ	LRRC49	666	Q8IUZ0
NIEVYNLMCDLLNLT	ENPP1	566	P22413
MTYIKCARNEQEQNL	PRDM12	161	Q9H4Q4
QKVNEIGIYLTDCME	ENTPD1	96	P49961
AVNCEQKQEYIQAIM	HOOK3	126	Q86VS8
QQHYLDVIKRMLVQC	IPO5	166	O00410
CNKIMAKILENYNTL	FAM13A	216	O94988
DYQLVQHEVLCSMKN	HIPK3	181	Q9H422
QVTEKLQLTYMEETC	ITGA9	541	Q13797
SDQFLNMVCVKLQEY	EXOC4	601	Q96A65
KCQELLNYIMDTVKD	ATM	116	Q13315
LMELALQQTYQDTCN	ADCY2	211	Q08462
YNDVLTKQQMLISCV	ATRX	2391	P46100
QAAMYVQLIEVVKFC	KLHL15	106	Q96M94
LRCEMEQQNQEYKIL	KRT17	356	Q04695
MKIYVENLIDCLNEK	GCFC2	326	P16383
TNYISICKMQEVLEE	EFCAB6	981	Q5THR3
MILTKAQYDEIAQCL	CDIN1	1	Q9Y2V0
TCKEFYQMKQTVLQL	CCBE1	201	Q6UXH8
RIMEFIKENCYQVLT	GIMD1	201	P0DJR0
LLQESNCSQYMEKVL	CUL2	226	Q13617
YRDIMVKVCDINLQS	DTHD1	251	Q6ZMT9
MQDCVQLNQYTLKDE	CAMKK2	156	Q96RR4
EMQECTTQIQYLKQV	WTAP	86	Q15007
QILDSRQVCVQYMKD	SLC13A5	71	Q86YT5
YIIHQEEICSSKLNM	SLC39A12	121	Q504Y0
QKAKQDMACLIREYQ	KRT83	381	P78385
ELMCKLIVAIDQYNT	NPBWR1	106	P48145
ELYQQLNDLEACVMQ	IFNA6	111	P05013
NDDVTNVIQKMICEY	IPO8	556	O15397
NVIQKMICEYSQEVA	IPO8	561	O15397
MEEITQQQLVHDKYC	MTOR	286	P42345
QLCSFQVIKDIMQQL	MROH5	716	Q6ZUA9
QLKVSNEEYACMKAI	NR6A1	381	Q15406
QQEYMTKVLECLQQK	RTEL1	21	Q9NZ71
CLFEDKVATMLQQQY	SZT2	191	Q5T011
TIKVYCQRMQEENIT	POLR2E	86	P19388
VLVMLKQTENNYLEC	SH3D19	441	Q5HYK7
TMKCIVNEYTFLLEQ	SAMD9	1361	Q5K651
IMINILQSCKDLQYH	FASTKD2	381	Q9NYY8
LVKEDNLLMAYQICF	PSMD1	236	Q99460
LNCTQKALMQVVDFL	NIF3L1	211	Q9GZT8
EFLKMDSLVEQCIQY	SANBR	236	Q6NSI8
QYVEELILQLLNMLC	SOS1	46	Q07889
MSLEQDNIKQAIFCY	GTF3C3	226	Q9Y5Q9
KMNQEQFIELCKTLY	TBC1D9B	1021	Q66K14
KNKNNICSYVDLMLV	B3GNT2	361	Q9NY97
AQDMKCVSIQYLEAV	ACY1	111	Q03154
QLNNMDEVCYENVLK	ASCC3	696	Q8N3C0
MQVICQSQLEIYKTI	CHST4	246	Q8NCG5
IKDMLLECFININYI	NCAPG2	206	Q86XI2
LKLMLQQCKTQYELG	SPG11	1606	Q96JI7
YCRILNQVEKNMQKV	RAPGEF2	231	Q9Y4G8
CLVVGLEQYEQMLKT	TNRC18	2921	O15417
LEQQMENLVVCVKYG	RLF	1581	Q13129
YLFNMCLQQLFEVKV	RNASEH2B	51	Q5TBB1
CVIIVCKMLYQLQTI	PIEZO2	991	Q9H5I5
CLMYINDKAQFLIQE	USP25	651	Q9UHP3
QEQAEKEMYSLCLLA	VCPIP1	886	Q96JH7
MNNVTTDYCLDIIKK	PLCH1	246	Q4KWH8
YELQLTQEKIMCLDE	TSGA10	226	Q9BZW7
AEKLIYNCAVEMVQS	ULK2	961	Q8IYT8
CLQLNMVYQEVIQEK	SNAPC4	86	Q5SXM2
MFYQLCDLNVEELQK	GTF3C5	406	Q9Y5Q8
QCYLLQTAMNLLDVE	TARBP1	531	Q13395
KYTCQELQRLMAEIQ	THOC5	56	Q13769
TIVQKCLEIYDMIGQ	UBR4	376	Q5T4S7
NVICQLLSDYKEKQM	POTEG	351	Q6S5H5
LNLLLECLKYQMDNA	TERB1	16	Q8NA31
KFLEVELCYMNTNLV	UNC13D	796	Q70J99
VTDTVVYQMNECQEK	USP44	326	Q9H0E7
MLEESKTLNVNCVDY	TRPC3	46	Q13507
LVACKDSNMELLYEQ	ULK4	1061	Q96C45
KMESYLKQQQLCDVI	KLHL1	201	Q9NR64
QKAKQDMACLIREYQ	KRT81	376	Q14533
QMVFCQDQIYSVVLK	MX2	576	P20592