Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	smooth endoplasmic reticulum	PDIA4 PSEN1 PGRMC1	1.61e-04	46	48	3	GO:0005790
Domain	HECT	UBE3C HERC1 UBE3A	4.46e-05	27	48	3	PF00632
Domain	HECTc	UBE3C HERC1 UBE3A	4.46e-05	27	48	3	SM00119
Domain	HECT_dom	UBE3C HERC1 UBE3A	4.46e-05	27	48	3	IPR000569
Domain	HECT	UBE3C HERC1 UBE3A	4.46e-05	27	48	3	PS50237
Domain	Cyt-b5	PGRMC1 PGRMC2	5.77e-04	14	48	2	PF00173
Domain	Cyt_B5-like_heme/steroid-bd	PGRMC1 PGRMC2	5.77e-04	14	48	2	IPR001199
Domain	Cyt-b5	PGRMC1 PGRMC2	5.77e-04	14	48	2	SM01117
Domain	-	PGRMC1 PGRMC2	5.77e-04	14	48	2	3.10.120.10
Domain	ZnF_U1	ZNF318 TUT7	2.51e-03	29	48	2	SM00451
Domain	Znf_U1	ZNF318 TUT7	2.51e-03	29	48	2	IPR003604
Pubmed	Human transcription factor protein interaction networks.	PDIA4 PWP1 RLF ZNF771 E2F3 RBM25 ZNF318 SUPT20H HERC1 EHMT2 PGRMC1 PURB SCAF4 BMS1	4.77e-09	1429	48	14	35140242
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PWP1 MCM2 MYOF RBM25 ZNF318 ABCF1 PGRMC1 FKBP5 PURB SCAF4	8.57e-08	774	48	10	15302935
Pubmed	Classic and non-classic progesterone receptors are both expressed in human spermatozoa.	PGRMC1 PGRMC2	1.87e-06	2	48	2	15702432
Pubmed	Expression patterns of progesterone receptor membrane components 1 and 2 in endometria from women with and without endometriosis.	PGRMC1 PGRMC2	1.87e-06	2	48	2	23793472
Pubmed	Changes in myometrial expression of progesterone receptor membrane components 1 and 2 are associated with human parturition at term.	PGRMC1 PGRMC2	1.87e-06	2	48	2	25266650
Pubmed	Myoferlin silencing inhibits VEGFR2-mediated proliferation of metastatic clear cell renal cell carcinoma.	MYOF KDR	1.87e-06	2	48	2	31477752
Pubmed	The role of progesterone receptor membrane component (PGRMC) in the endometrium.	PGRMC1 PGRMC2	1.87e-06	2	48	2	35526781
Pubmed	Cloning and tissue expression of two putative steroid membrane receptors.	PGRMC1 PGRMC2	1.87e-06	2	48	2	9705155
Pubmed	Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome.	PIEZO2 UBE3A	1.87e-06	2	48	2	36859399
Pubmed	PGRMC2 is an intracellular haem chaperone critical for adipocyte function.	PGRMC1 PGRMC2	1.87e-06	2	48	2	31748741
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	PDIA4 PWP1 MCM2 RBM25 ABCF1 UBE3C PURB SCAF4	2.88e-06	653	48	8	33742100
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PDIA4 PWP1 FRYL RBM25 ZNF318 ABCF1 TUT7 BMS1	2.88e-06	653	48	8	22586326
Pubmed	Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence.	PGRMC1 PGRMC2	5.59e-06	3	48	2	28005395
Pubmed	A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase.	PGRMC1 PGRMC2	5.59e-06	3	48	2	27599036
Pubmed	PGRMC1/2 promotes luteal vascularization and maintains the primordial follicles of mice.	PGRMC1 PGRMC2	5.59e-06	3	48	2	30306772
Pubmed	Progesterone protects ovarian cancer cells from cisplatin-induced inhibitory effects through progesterone receptor membrane component 1/2 as well as AKT signaling.	PGRMC1 PGRMC2	5.59e-06	3	48	2	23970345
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	PDIA4 TMOD1 ZNF318 UBE3C PSEN1 UBE3A TUT7 BMS1	8.25e-06	754	48	8	33060197
Pubmed	E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein.	HERC1 UBE3A	1.12e-05	4	48	2	24155239
Pubmed	Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.	PCSK5 KDR	1.12e-05	4	48	2	17242158
Pubmed	Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function.	MYOF KDR	1.12e-05	4	48	2	17702744
Pubmed	UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells.	MCM2 UBE3A	1.12e-05	4	48	2	37454373
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	PDIA4 CNDP2 MCM2 FRYL ABCF1 UBE3C HERC1 UBE3A FKBP5 PURB	2.43e-05	1455	48	10	22863883
Pubmed	A protein interaction landscape of breast cancer.	PWP1 E2F3 UBE3C PSEN1 MTF2 FKBP5 SCAF4	2.49e-05	634	48	7	34591612
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	PWP1 MCM2 ZNF318 ABCF1 TUT7 MAP3K4	3.10e-05	440	48	6	34244565
Pubmed	Abnormal blood vessel development in mice lacking presenilin-1.	KDR PSEN1	3.90e-05	7	48	2	12834865
Pubmed	Patterns of cell signaling pathway activation that characterize mammary development.	E2F3 MAP3K4	3.90e-05	7	48	2	18550711
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	TMOD1 HERC1 DNAJC14 PCLO BMS1	4.00e-05	277	48	5	30745168
Pubmed	Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense.	UBE3C UBE3A	5.19e-05	8	48	2	31812350
Pubmed	MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.	FRYL ZNF318 ABCF1 SCAF4	5.58e-05	150	48	4	22678362
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	ABCF1 SUPT20H HERC1 ARMH3 MAP3K4 SCAF4	6.10e-05	497	48	6	36774506
Pubmed	Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7.	UBE3C UBE3A	6.67e-05	9	48	2	9575161
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	PDIA4 MCM2 RBM25 ZNF318 ABCF1 PGRMC1 PGRMC2 SCAF4	7.29e-05	1024	48	8	24711643
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	PWP1 ZNF771 TMOD1 ABCF1 UBE3C TUT7 BMS1	7.75e-05	759	48	7	35915203
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	PWP1 TMOD1 RBM25 PGRMC1 PURB TUT7 PGRMC2 SCAF4 BMS1	9.37e-05	1371	48	9	36244648
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	PWP1 RBM25 ABCF1 PGRMC1 FKBP5 TUT7	1.03e-04	547	48	6	37267103
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	E2F3 ZNF318 SUPT20H SCAF4 BMS1	1.04e-04	339	48	5	30415952
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	MYOF RBM25 PGRMC1 PURB SCAF4	1.05e-04	340	48	5	24332808
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PWP1 RBM25 ABCF1 SUPT20H PGRMC1 PGRMC2 SCAF4 BMS1	1.07e-04	1082	48	8	38697112
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	PDIA4 PWP1 MCM2 ABCF1 BMS1	1.19e-04	349	48	5	25665578
Pubmed	Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.	RBM25 PSEN1	1.22e-04	12	48	2	7596406
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PDIA4 PWP1 MCM2 RBM25 ABCF1 UBE3C PGRMC1 PCLO BMS1	1.26e-04	1425	48	9	30948266
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	TMOD1 MCM2 MYOF UBE3C PGRMC1 FKBP5 PURB PGRMC2 BMS1	1.36e-04	1440	48	9	30833792
Pubmed	Pathway analysis in HEK 293T cells overexpressing HIV-1 tat and nucleocapsid.	PCSK5 KDR	1.44e-04	13	48	2	19884766
Pubmed	A conserved catalytic residue in the ubiquitin-conjugating enzyme family.	UBE3C UBE3A	1.44e-04	13	48	2	14517261
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	PDIA4 CNDP2 ABCF1 DNAJC14 EHMT2 PGRMC1 FKBP5 PGRMC2 BMS1	1.73e-04	1487	48	9	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RLF CNDP2 E2F3 INTU FRYL UBE3C TTLL3 GALNT11 FKBP5	1.75e-04	1489	48	9	28611215
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MYOF FRYL TUT7 BMS1	1.76e-04	202	48	4	33005030
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	PDIA4 UBE3C HERC1 EHMT2 PCLO PURB TUT7 PGRMC2 BMS1	1.81e-04	1496	48	9	32877691
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PWP1 MYOF ZNF318 ABCF1 SUPT20H EHMT2 PURB SCAF4 BMS1	1.82e-04	1497	48	9	31527615
Pubmed	Redundant role of protein kinase C delta and epsilon during mouse embryonic development.	MCM2 KDR	1.94e-04	15	48	2	25084151
Pubmed	A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.	UBE3C UBE3A	2.21e-04	16	48	2	22496338
Pubmed	Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.	RBM25 HERC1 UBE3A	2.25e-04	85	48	3	16051665
Pubmed	Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.	PDIA4 MCM2 RBM25 ABCF1 BMS1	2.32e-04	403	48	5	35253629
Pubmed	Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment.	KDR EHMT2	2.50e-04	17	48	2	20573702
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	PDIA4 MCM2 UBE3C PGRMC1 PURB PGRMC2	2.56e-04	647	48	6	26618866
Pubmed	A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.	MTF2 EHMT2	2.81e-04	18	48	2	29628311
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	UBE3C HERC1 UBE3A	3.12e-04	95	48	3	29643511
Pubmed	Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology.	RBM25 UBE3A	3.14e-04	19	48	2	34467244
Pubmed	Autoregulation of the 26S proteasome by in situ ubiquitination.	UBE3C UBE3A	3.14e-04	19	48	2	24743594
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	PDIA4 PWP1 MCM2 UBE3C PGRMC1 FKBP5 BMS1	3.58e-04	974	48	7	28675297
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	PWP1 MCM2 ABCF1 PSEN1	3.72e-04	246	48	4	15345747
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	MCM2 ABCF1 EHMT2 UBE3A FKBP5 MAP3K4	4.01e-04	704	48	6	29955894
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	PWP1 RBM25 ABCF1 PURB SCAF4 BMS1	4.29e-04	713	48	6	29802200
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	CNDP2 MCM2 RBM25 SUPT20H EHMT2 UBE3A FKBP5	4.55e-04	1014	48	7	32416067
Pubmed	Toward a complete human genome sequence.	PDIA4 FRYL RBM25 GALNT11 PCLO PURB	4.65e-04	724	48	6	9847074
Pubmed	HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development.	MCM2 KDR	5.05e-04	24	48	2	21149574
Pubmed	c-IAP1 binds and processes PCSK9 protein: linking the c-IAP1 in a TNF-α pathway to PCSK9-mediated LDLR degradation pathway.	PDIA4 PGRMC1	5.05e-04	24	48	2	23085658
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	PWP1 RBM25 ABCF1 UBE3C BMS1	5.45e-04	486	48	5	30940648
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	UBE3C HERC1	5.93e-04	26	48	2	26949039
Pubmed	Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation.	KDR EHMT2	5.93e-04	26	48	2	28087629
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	PWP1 ABCF1 PCLO PURB TUT7	5.97e-04	496	48	5	31343991
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	MYOF PGRMC1 UBE3A PCLO PGRMC2	6.14e-04	499	48	5	22810586
Pubmed	Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter.	PGRMC1 PGRMC2	6.40e-04	27	48	2	34709416
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	PDIA4 FRYL ZNF318 TTLL3 HERC1 PURB TUT7	6.76e-04	1084	48	7	11544199
Pubmed	Identification of novel transcription-regulating genes expressed during murine molar development.	MCM2 EHMT2	7.39e-04	29	48	2	22639370
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	PDIA4 RLF ZNF318 ABCF1 FKBP5 PURB SCAF4	7.49e-04	1103	48	7	34189442
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCSK5 MYOF FRYL UBE3C PGAP3 HERC1 DNAJC14	7.57e-04	1105	48	7	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF771 INTU RBM25 ZNF318 SUPT20H EHMT2 GRAP2	8.02e-04	1116	48	7	31753913
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	RBM25 ABCF1 PURB TUT7 SCAF4 BMS1	8.20e-04	807	48	6	22681889
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	FRYL RBM25 UBE3C MAP3K4 SCAF4	8.46e-04	536	48	5	15840001
Pubmed	Human chromosome 7: DNA sequence and biology.	PDIA4 UBE3C GALNT11 PCLO PURB	8.46e-04	536	48	5	12690205
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	FRYL RBM25 UBE3C MAP3K4 SCAF4	8.60e-04	538	48	5	10512203
Pubmed	Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.	KDR PSEN1	9.58e-04	33	48	2	16000382
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	MYOF PSEN1 PGRMC1 TUT7 PGRMC2 SCAF4	1.13e-03	859	48	6	31536960
Pubmed	Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).	MCM2 UBE3C	1.20e-03	37	48	2	7584028
Pubmed	Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.	RLF KDR	1.27e-03	38	48	2	29743679
Pubmed	Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis.	KDR PSEN1	1.27e-03	38	48	2	22783020
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	PDIA4 CNDP2 MCM2 MYOF	1.30e-03	344	48	4	30333137
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	FRYL ABCF1 BMS1	1.32e-03	156	48	3	22952844
Interaction	PSMD14 interactions	TMOD1 UBE3C HERC1 PSEN1 DNAJC14 EHMT2 UBE3A PCLO BMS1	3.61e-06	527	48	9	int:PSMD14
Cytoband	Ensembl 112 genes in cytogenetic band chr7q36	PDIA4 UBE3C GALNT11	6.29e-04	159	48	3	chr7q36
Cytoband	6p21.31	EHMT2 FKBP5	8.55e-04	41	48	2	6p21.31
Cytoband	Ensembl 112 genes in cytogenetic band chr6p21	ZNF318 ABCF1 EHMT2 FKBP5	1.89e-03	503	48	4	chr6p21
Cytoband	Ensembl 112 genes in cytogenetic band chr4q28	INTU PGRMC2	3.29e-03	81	48	2	chr4q28
Cytoband	14q24.3	RBM25 PSEN1	4.31e-03	93	48	2	14q24.3
GeneFamily	Membrane associated progesterone receptor family	PGRMC1 PGRMC2	2.05e-05	4	34	2	1282
CoexpressionAtlas	DevelopingGonad_e14.5_ testes_emap-6710_k-means-cluster#5_top-relative-expression-ranked_1000	PWP1 RBM25 ABCF1 MTF2 EHMT2 FKBP5 PURB	4.71e-05	429	48	7	gudmap_developingGonad_e14.5_ testes_1000_k5
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_1000	RLF PCSK5 KDR RBM25 PIEZO2 HERC1 MTF2 UBE3A PURB	6.61e-05	801	48	9	gudmap_developingGonad_e14.5_ epididymis_1000
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000	RLF PCSK5 KDR RBM25 ZNF318 ABCF1 HERC1 MTF2 PURB	6.93e-05	806	48	9	gudmap_developingGonad_e12.5_epididymis_1000
ToppCell	356C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CARD6 CHSY3 ZNF318 PROZ CCDC191	1.06e-06	169	48	5	0425d2580ed325178f522c0093ff4623de6ce7a8
ToppCell	356C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CARD6 CHSY3 ZNF318 PROZ CCDC191	1.06e-06	169	48	5	fec669968a77060bd77ee8695034e35a642c984f
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MCM2 ZNF318 DNAJC14 MAP3K4	8.00e-06	118	48	4	3b077ad5c68c01b3fcc93f203cb130bb90705af9
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MCM2 ZNF318 DNAJC14 MAP3K4	8.00e-06	118	48	4	08bdf7bc3c9dcbc0f690658fe14e6cc4b9581698
ToppCell	Control-B_naive-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ZNF318 ARMH3 CCDC191 TUT7	2.34e-05	155	48	4	0a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRYL PROZ HERC1 PCLO	3.68e-05	174	48	4	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 KDR CHSY3 PIEZO2	3.94e-05	177	48	4	c274fbdc141855ff4581d437d4997c64cc193278
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 KDR CHSY3 PIEZO2	3.94e-05	177	48	4	c8a51e480b978dc0ded85583261f2c892e085be8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 KDR CHSY3 PIEZO2	3.94e-05	177	48	4	f5e6df5cafd003bbfbb3b634ee58d0b1e2be5cc7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 KDR CHSY3 PIEZO2	4.39e-05	182	48	4	41b070085edba7a58b81c20aa4942d06f745acf8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 KDR CHSY3 PIEZO2	4.39e-05	182	48	4	5e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 KDR CHSY3 PIEZO2	4.39e-05	182	48	4	b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell	18-Distal-Epithelial-Epithelial\|Distal / Age, Tissue, Lineage and Cell class	TMOD1 TMEM169 SCGN PCLO	4.67e-05	185	48	4	d2a266724f3f70f746a78034f308d98f8b7a66e3
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 KDR CHSY3 PIEZO2	4.87e-05	187	48	4	65d406122dffe18279f14a1ed35ba091730b97be
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 KDR CHSY3 PIEZO2	4.87e-05	187	48	4	4c15c0ed41a55271fc793cb76fee97fa64190369
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 KDR CHSY3 PIEZO2	4.87e-05	187	48	4	5274f2b302bbf7fed30c480af4f35058d2cf61e0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 KDR CHSY3 PIEZO2	5.18e-05	190	48	4	876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 KDR CHSY3 PIEZO2	5.18e-05	190	48	4	be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 KDR CHSY3 PIEZO2	5.18e-05	190	48	4	09a8855901c3c9332dbaab3e40166485b696d0f1
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	MCM2 ZNF318 DNAJC14 MAP3K4	5.62e-05	194	48	4	4c40d6b50675eae52c419d69e719a9223df02ae3
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)\|356C / Donor, Lineage, Cell class and subclass (all cells)	MCM2 ZNF318 DNAJC14 MAP3K4	5.62e-05	194	48	4	99a90de637e3babec2131cdd9f05ea965d8a8f30
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FRYL RBM25 HERC1 MAP3K4	5.97e-05	197	48	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHSY3 HERC1 UBE3A PCLO	6.08e-05	198	48	4	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	CHSY3 HERC1 UBE3A PCLO	6.33e-05	200	48	4	48d801219bc771d6c7e151dc88ca4c179988de85
Computational	Neighborhood of DDB1	PDIA4 PWP1 MCM2 ABCF1 UBE3C BMS1	1.06e-04	246	34	6	MORF_DDB1
Drug	Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A	RLF E2F3 RBM25 MTF2 UBE3A TUT7 MAP3K4	8.92e-08	182	47	7	3887_DN
Disease	Schizoaffective disorder-bipolar type	PCLO PURB	2.81e-04	16	46	2	EFO_0009965
Disease	melanoma (is_marker_for)	KDR EHMT2	1.22e-03	33	46	2	DOID:1909 (is_marker_for)
Disease	lifestyle measurement, anxiety disorder measurement	INTU PIEZO2 ARMH3	1.28e-03	137	46	3	EFO_0007795, EFO_0010724
Disease	Nodular glomerulosclerosis	CNDP2 KDR	1.88e-03	41	46	2	C0017667
Disease	high grade glioma (is_marker_for)	E2F3 KDR	1.97e-03	42	46	2	DOID:3070 (is_marker_for)
Disease	Diabetic Nephropathy	CNDP2 KDR	2.16e-03	44	46	2	C0011881
Disease	ocular hypertension, response to triamcinolone acetonide	TTLL3 TUT7	2.67e-03	49	46	2	EFO_0006954, EFO_1001069

Protein segments in the cluster

Peptide	Gene	Start	Entry
YLEEEEDLEEEEYLG	ERICH6B	61	Q5W0A0
EDLEEEEYLGKEEYL	ERICH6B	66	Q5W0A0
DGDFEDYKREVLEAL	ABCF1	821	Q8NE71
LEYLEGKLESLDGEE	ARMH3	56	Q5T2E6
EDDSYLFDLDNKDGE	EHMT2	1081	Q96KQ7
KVLAEDEELYGDFED	BMS1	771	Q14692
VKDDEGKEDYQFDEL	MTF2	516	Q9Y483
LKEFLEDYDDDRDDP	RBM25	496	P49756
DDDYLDLEKIFSEDD	SERPIND1	76	P05546
ELDAYEAEGLALDDE	MCM2	86	P49736
EIELLDFKGEDLFED	FKBP5	131	Q13451
ELEEEYDDEESLKFP	DNAJC14	166	Q6Y2X3
LYDFNLDEELEIDLD	HERC1	2921	Q15751
DEDDEAFDESPELKY	PCLO	1631	Q9Y6V0
FKYGLLDDDDIDELE	PCSK5	1836	Q92824
DKEALKDEYDDLSDL	PGRMC1	131	O00264
DKDALRDEYDDLSDL	PGRMC2	161	O15173
KDFDFLDVELEDAEG	FRYL	2426	O94915
DDSDFDDLKGELDEY	GALNT11	191	Q8NCW6
KNGELFYLELSEDEE	INTU	61	Q9ULD6
EELDDSLYLGKEEYL	CARD6	201	Q9BX69
EEGISDLFDAYDLEK	E2F3	441	O00716
KFDDLCGYLEEEEES	CCDC191	136	Q8NCU4
ARALYDFEALEDDEL	GRAP2	276	O75791
ADEKGYIEEKELDAF	SCGN	26	O76038
AFDKKLLDRFDYDDE	SCAF4	256	O95104
LAKLIDDYGGEDDEL	PURB	186	Q96QR8
FLEDDSLYLLKESED	PGAP3	301	Q96FM1
EYEGDDTEGELKELE	MAP3K4	441	Q9Y6R4
EDDIDLLGEEFRKVY	MNS1	471	Q8NEH6
DEEEDEELTLKYGAK	PSEN1	66	P49768
AIADEEDYAGEVKDL	PDIA4	451	P13667
LEELFEGNLEKECYE	PROZ	46	P22891
DDDVYIKGDKLEEFL	CHSY3	261	Q70JA7
LYDDIDFDIEEFAKD	CNDP2	276	Q96KP4
TLDDDELAEYDLDKY	PWP1	86	Q13610
ELAEYDLDKYDEEGD	PWP1	91	Q13610
LLVKGEEDEGEEKYE	ZNF771	21	Q7L3S4
SLKDLLEYEGNVEDD	UBE3A	661	Q05086
VLESFLSDYDEGKED	RLF	506	Q13129
ELEKYRDLDEDEILG	TMOD1	6	P28289
YEEGELLEYLDAEEL	SUPT20H	106	Q8NEM7
GELELEEDLYAKLIF	PIEZO2	2721	Q9H5I5
LFDFDDLLKFDDLDG	TTLL3	86	Q9Y4R7
VEEEEAPEDLYKDFL	KDR	986	P35968
KEEEGDDFLDYPVDD	TMEM169	76	Q96HH4
ALSEEDDELGEAAKY	TUT7	891	Q5VYS8
DDELGEAAKYEDVKE	TUT7	896	Q5VYS8
IEDEEKFLYGDEEED	ZNF318	531	Q5VUA4
KFLYGDEEEDLKAES	ZNF318	536	Q5VUA4
LFLKSYEDDVEELGL	UBE3C	871	Q15386
DKFSLDDYLGFLELD	MYOF	1891	Q9NZM1