Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Pept_S9A_N	PREPL PREP	2.61e-05	2	96	2	IPR023302
Domain	Peptidase_S9_N	PREPL PREP	2.61e-05	2	96	2	PF02897
Domain	Peptidase_S9A	PREPL PREP	2.61e-05	2	96	2	IPR002470
Domain	ARM-type_fold	DOCK11 DOCK8 NF1 PLAA PSME4 PIK3C2B PIK3CG ASPM UNC79	6.23e-05	339	96	9	IPR016024
Domain	PRO_ENDOPEP_SER	PREPL PREP	2.59e-04	5	96	2	PS00708
Domain	DUF3398	DOCK11 DOCK8	3.87e-04	6	96	2	PF11878
Domain	DOCK_C/D_N	DOCK11 DOCK8	3.87e-04	6	96	2	IPR021816
Domain	PI3K_Ras-bd_dom	PIK3C2B PIK3CG	5.40e-04	7	96	2	IPR000341
Domain	PI3K_rbd	PIK3C2B PIK3CG	5.40e-04	7	96	2	PF00794
Domain	PI3K_RBD	PIK3C2B PIK3CG	5.40e-04	7	96	2	PS51546
Domain	CHCR	VPS18 VPS39	5.40e-04	7	96	2	PS50236
Domain	PI3K_rbd	PIK3C2B PIK3CG	5.40e-04	7	96	2	SM00144
Domain	PI3K_C2_dom	PIK3C2B PIK3CG	7.17e-04	8	96	2	IPR002420
Domain	Clathrin_H-chain/VPS_repeat	VPS18 VPS39	7.17e-04	8	96	2	IPR000547
Domain	Gprotein_alpha_I	GNAT3 GNAT2	7.17e-04	8	96	2	IPR001408
Domain	PI3K_C2	PIK3C2B PIK3CG	7.17e-04	8	96	2	PF00792
Domain	PI3K_C2	PIK3C2B PIK3CG	7.17e-04	8	96	2	PS51547
Domain	PI3K_C2	PIK3C2B PIK3CG	7.17e-04	8	96	2	SM00142
Domain	PI3Ka	PIK3C2B PIK3CG	9.19e-04	9	96	2	PF00613
Domain	-	PIK3C2B PIK3CG	9.19e-04	9	96	2	1.25.40.70
Domain	PI3Ka	PIK3C2B PIK3CG	9.19e-04	9	96	2	SM00145
Domain	PIK_HELICAL	PIK3C2B PIK3CG	1.15e-03	10	96	2	PS51545
Domain	PI_Kinase	PIK3C2B PIK3CG	1.15e-03	10	96	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3C2B PIK3CG	1.15e-03	10	96	2	IPR001263
Domain	Peptidase_S9	PREPL PREP	1.40e-03	11	96	2	PF00326
Domain	DOCK_C	DOCK11 DOCK8	1.40e-03	11	96	2	IPR010703
Domain	DHR-1_domain	DOCK11 DOCK8	1.40e-03	11	96	2	IPR027007
Domain	DHR_2	DOCK11 DOCK8	1.40e-03	11	96	2	PS51651
Domain	DHR_1	DOCK11 DOCK8	1.40e-03	11	96	2	PS51650
Domain	DOCK-C2	DOCK11 DOCK8	1.40e-03	11	96	2	PF14429
Domain	DHR-2	DOCK11 DOCK8	1.40e-03	11	96	2	IPR027357
Domain	DHR-2	DOCK11 DOCK8	1.40e-03	11	96	2	PF06920
Domain	ZnF_UBP	HDAC6 USP39	1.40e-03	11	96	2	SM00290
Domain	Peptidase_S9	PREPL PREP	1.40e-03	11	96	2	IPR001375
Domain	DOCK	DOCK11 DOCK8	1.40e-03	11	96	2	IPR026791
Domain	RasGAP	RASA1 NF1	2.29e-03	14	96	2	SM00323
Domain	Znf_UBP	HDAC6 USP39	2.29e-03	14	96	2	IPR001607
Domain	zf-UBP	HDAC6 USP39	2.29e-03	14	96	2	PF02148
Domain	ZF_UBP	HDAC6 USP39	2.29e-03	14	96	2	PS50271
Domain	RasGAP_CS	RASA1 NF1	2.29e-03	14	96	2	IPR023152
Domain	Ubiquitin-rel_dom	GRB7 PTPN13 PIK3C2B PIK3CG FRMD5	2.61e-03	184	96	5	IPR029071
Domain	RasGAP	RASA1 NF1	2.63e-03	15	96	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA1 NF1	2.63e-03	15	96	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	RASA1 NF1	2.63e-03	15	96	2	PS50018
Domain	PI3/4_kinase_CS	PIK3C2B PIK3CG	2.63e-03	15	96	2	IPR018936
Domain	G-alpha	GNAT3 GNAT2	2.99e-03	16	96	2	PF00503
Domain	GproteinA_insert	GNAT3 GNAT2	2.99e-03	16	96	2	IPR011025
Domain	-	PIK3C2B PIK3CG	2.99e-03	16	96	2	1.10.1070.11
Domain	-	GNAT3 GNAT2	2.99e-03	16	96	2	1.10.400.10
Domain	PI3Kc	PIK3C2B PIK3CG	2.99e-03	16	96	2	SM00146
Domain	G_alpha	GNAT3 GNAT2	2.99e-03	16	96	2	SM00275
Domain	Gprotein_alpha_su	GNAT3 GNAT2	3.38e-03	17	96	2	IPR001019
Domain	PI3/4_kinase_cat_dom	PIK3C2B PIK3CG	3.79e-03	18	96	2	IPR000403
Domain	PI3_PI4_kinase	PIK3C2B PIK3CG	3.79e-03	18	96	2	PF00454
Domain	RasGAP_dom	RASA1 NF1	3.79e-03	18	96	2	IPR001936
Domain	PI3_4_KINASE_3	PIK3C2B PIK3CG	3.79e-03	18	96	2	PS50290
Domain	PI3_4_KINASE_1	PIK3C2B PIK3CG	3.79e-03	18	96	2	PS00915
Domain	PI3_4_KINASE_2	PIK3C2B PIK3CG	3.79e-03	18	96	2	PS00916
Domain	-	RASA1 KALRN DOCK11 GRB7 EXOC8 PTPN13 FRMD5	4.04e-03	391	96	7	2.30.29.30
Pathway	PID_EPHB_FWD_PATHWAY	RASA1 KALRN GRB7 SYNJ1 MAPK1	8.85e-07	40	63	5	M62
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	PTPN13 SYNJ1 PIK3C2B PIK3CG PIP4K2B	2.75e-06	50	63	5	MM14641
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	PTPN13 SYNJ1 PIK3C2B PIK3CG PIP4K2B	3.69e-06	53	63	5	M662
Pathway	REACTOME_PI_METABOLISM	PTPN13 SYNJ1 PIK3C2B PIK3CG PIP4K2B	2.34e-05	77	63	5	MM14590
Pathway	REACTOME_PI_METABOLISM	PTPN13 SYNJ1 PIK3C2B PIK3CG PIP4K2B	3.57e-05	84	63	5	M676
Pathway	KEGG_INOSITOL_PHOSPHATE_METABOLISM	SYNJ1 PIK3C2B PIK3CG PIP4K2B	9.69e-05	54	63	4	M3896
Pathway	PID_FCER1_PATHWAY	RASA1 PTPN13 MS4A2 MAPK1	1.46e-04	60	63	4	M7
Pathway	WP_EPO_RECEPTOR_SIGNALING	RASA1 PIK3CG MAPK1	2.06e-04	26	63	3	M39687
Pathway	WP_EPO_RECEPTOR_SIGNALING	RASA1 PIK3CG MAPK1	2.06e-04	26	63	3	MM15896
Pathway	REACTOME_PHOSPHOLIPID_METABOLISM	PTPN13 SYNJ1 PIK3C2B PIK3CG PLA2G4B PIP4K2B	2.35e-04	196	63	6	MM14591
Pathway	WP_RAC1PAK1P38MMP2_PATHWAY	RASA1 GRB7 NFKBIA MAPK1	2.38e-04	68	63	4	M39456
Pathway	WP_KIT_RECEPTOR_SIGNALING_PATHWAY	RASA1 GRB7 PIK3CG MAPK1	2.81e-04	71	63	4	MM15947
Pathway	BIOCARTA_SAM68_PATHWAY	RASA1 MAPK1	2.91e-04	6	63	2	MM1567
Pathway	BIOCARTA_SAM68_PATHWAY	RASA1 MAPK1	2.91e-04	6	63	2	M22052
Pathway	REACTOME_PHOSPHOLIPID_METABOLISM	PTPN13 SYNJ1 PIK3C2B PIK3CG PLA2G4B PIP4K2B	3.50e-04	211	63	6	M649
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	SYNJ1 PIK3C2B PIK3CG PIP4K2B	3.65e-04	76	63	4	M9052
Pathway	PID_SYNDECAN_2_PATHWAY	RASA1 NF1 MAPK1	4.22e-04	33	63	3	M240
Pathway	WP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION	PIK3CG NFKBIA MAPK1	4.22e-04	33	63	3	M39745
Pathway	BIOCARTA_MET_PATHWAY	RASA1 PIK3CG MAPK1	4.22e-04	33	63	3	M19358
Pathway	BIOCARTA_MET_PATHWAY	RASA1 PIK3CG MAPK1	4.22e-04	33	63	3	MM1494
Pathway	KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY	MS4A2 PIK3CG PLA2G4B MAPK1	4.23e-04	79	63	4	M11816
Pathway	WP_GLIOBLASTOMA_SIGNALING	NF1 PIK3C2B PIK3CG MAPK1	5.11e-04	83	63	4	M39637
Pathway	PID_RET_PATHWAY	RASA1 GRB7 MAPK1	6.93e-04	39	63	3	M82
Pathway	BIOCARTA_FCER1_PATHWAY	MS4A2 PIK3CG MAPK1	6.93e-04	39	63	3	MM1397
Pathway	BIOCARTA_FCER1_PATHWAY	MS4A2 PIK3CG MAPK1	6.93e-04	39	63	3	M1908
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SIFA_TO_TETHERING_OF_LATE_ENDOSOMES_AND_LYSOSOMES	VPS18 VPS39	6.93e-04	9	63	2	M47777
Pathway	WP_PDGF_PATHWAY	RASA1 NFKBIA MAPK1	7.47e-04	40	63	3	M39555
Pathway	BIOCARTA_TCR_PATHWAY	RASA1 PIK3CG NFKBIA	8.62e-04	42	63	3	MM1504
Pathway	KEGG_MEDICUS_REFERENCE_TETHERING_OF_LATE_ENDOSOMES_AND_LYSOSOMES	VPS18 VPS39	8.64e-04	10	63	2	M47776
Pathway	KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	PIK3CG PLA2G4B PIP4K2B MAPK1	8.85e-04	96	63	4	M16121
Pathway	REACTOME_SUMOYLATION	NUP85 XPC PGR NFKBIA SENP5	9.36e-04	169	63	5	MM14919
Pathway	BIOCARTA_TCR_PATHWAY	RASA1 PIK3CG NFKBIA	9.89e-04	44	63	3	M19784
Pathway	REACTOME_SARS_COV_2_MODULATES_AUTOPHAGY	VPS18 VPS39	1.05e-03	11	63	2	M45018
Pathway	REACTOME_FORMATION_OF_APOPTOSOME	UACA MAPK1	1.05e-03	11	63	2	M41721
Pathway	WP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY	PIK3C2B PIK3CG PIP4K2B	1.13e-03	46	63	3	M48317
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	ABCC1 DIS3L2 HDAC6 ABHD10 EXOC8 PSME4 PREP	8.58e-07	183	97	7	31932471
Pubmed	p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons.	NF1 PIK3CG MAPK1	3.41e-06	11	97	3	9852579
Pubmed	Defining the membrane proteome of NK cells.	ABCC1 EXOSC10 CHERP NUP85 DOCK8 HLA-DPB1 OPA1 EXOC8 NMD3 NF1 PREP PIK3CG HS2ST1 GOLGB1	4.48e-06	1168	97	14	19946888
Pubmed	RASA1 and NF1 are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non-Small Cell Lung Carcinomas Sensitive to MEK Inhibition.	RASA1 NF1	7.70e-06	2	97	2	29127119
Pubmed	Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing.	OPA1 PSME4	7.70e-06	2	97	2	33562813
Pubmed	Beta-hydroxy-beta-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways.	PIK3CG MAPK1	7.70e-06	2	97	2	19211028
Pubmed	Association of protein-tyrosine phosphatase PTP-BAS with the transcription-factor-inhibitory protein IkappaBalpha through interaction between the PDZ1 domain and ankyrin repeats.	PTPN13 NFKBIA	7.70e-06	2	97	2	9882613
Pubmed	Neurofibromatosis type I tumor suppressor neurofibromin regulates neuronal differentiation via its GTPase-activating protein function toward Ras.	RASA1 NF1	7.70e-06	2	97	2	12730209
Pubmed	Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: differences in asthma.	PIK3CG MAPK1	7.70e-06	2	97	2	18338817
Pubmed	Identification of IkappaBalpha as a substrate of Fas-associated phosphatase-1.	PTPN13 NFKBIA	7.70e-06	2	97	2	11106428
Pubmed	Abnormal circadian oscillation of hippocampal MAPK activity and power spectrums in NF1 mutant mice.	NF1 MAPK1	7.70e-06	2	97	2	28673309
Pubmed	Nuclear factor 1 synergizes with progesterone receptor on the mouse mammary tumor virus promoter wrapped around a histone H3/H4 tetramer by facilitating access to the central hormone-responsive elements.	PGR NF1	7.70e-06	2	97	2	19940123
Pubmed	Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5.	DUSP5 MAPK1	7.70e-06	2	97	2	15713638
Pubmed	HDAC6 mediates HIV-1 tat-induced proinflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes.	HDAC6 NFKBIA MAPK1	9.34e-06	15	97	3	26031809
Pubmed	HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex.	PIK3C2B PIK3CG MAPK1	9.34e-06	15	97	3	18854243
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	EXOSC10 HDAC6 VPS39 TBCCD1 PTPN13 PLAA PSME4 SYNJ1 MKLN1 MAPK1 GOLGB1 WDFY1 ZNF445	1.01e-05	1084	97	13	11544199
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	ABCC1 UACA OPA1 PTPN13 NF1	1.12e-05	104	97	5	31240132
Pubmed	Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice.	PIK3C2B PIK3CG MAPK1	1.15e-05	16	97	3	20019835
Pubmed	Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes.	PIK3C2B PIK3CG NFKBIA	1.39e-05	17	97	3	23251686
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	EXOSC10 NUP85 DUSP5 PREPL POF1B OPA1 EXOC8 TBCCD1 TRMT10C PREP UBAC2 MAPK1	1.75e-05	974	97	12	28675297
Pubmed	Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk.	NF1 MAPK1	2.31e-05	3	97	2	23221339
Pubmed	Direct effects of polymyxin B on human dendritic cells maturation. The role of IkappaB-alpha/NF-kappaB and ERK1/2 pathways and adhesion.	NFKBIA MAPK1	2.31e-05	3	97	2	15671028
Pubmed	Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex.	HDAC6 MKLN1	2.31e-05	3	97	2	28668087
Pubmed	Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.	RASA1 NF1	2.31e-05	3	97	2	26002977
Pubmed	USP39 Regulates NF-κB-Mediated Inflammatory Responses through Deubiquitinating K48-Linked IκBα.	NFKBIA USP39	2.31e-05	3	97	2	36651806
Pubmed	Immunoreactivity of progesterone receptor isoform B, nuclear factor kappaB, and IkappaBalpha in adenomyosis.	PGR NFKBIA	2.31e-05	3	97	2	19296948
Pubmed	Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein.	RASA1 NF1	2.31e-05	3	97	2	7477259
Pubmed	RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation.	PRDM1 RORC	2.31e-05	3	97	2	30478092
Pubmed	Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling.	RASA1 NFKBIA	2.31e-05	3	97	2	12151397
Pubmed	Prolongation of insulin-induced activation of mitogen-activated protein kinases ERK 1/2 and phosphatidylinositol 3-kinase by vanadyl sulfate, a protein tyrosine phosphatase inhibitor.	PIK3CG MAPK1	2.31e-05	3	97	2	14622970
Pubmed	Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration.	HDAC6 MAPK1	2.31e-05	3	97	2	24089523
Pubmed	LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.	DOCK8 LRCH1	2.31e-05	3	97	2	28028151
Pubmed	PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture.	PIK3CG MAPK1	2.31e-05	3	97	2	19457236
Pubmed	A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer.	RASA1 NF1	2.31e-05	3	97	2	28108518
Pubmed	Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells.	NFKBIA MAPK1	2.31e-05	3	97	2	15173174
Pubmed	Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations.	PIK3CG MAPK1	2.31e-05	3	97	2	19445727
Pubmed	Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis.	PIK3C2B PIK3CG	2.31e-05	3	97	2	23320105
Pubmed	Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia.	PIK3C2B PIK3CG MAPK1	3.58e-05	23	97	3	19047410
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	HDAC6 TTC28 DOCK11 DOCK8 LRCH1 KIAA1671 PTPN13 NF1	3.67e-05	446	97	8	24255178
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TTC28 VPS39 KIAA0232 LRCH1 SYNJ1 PCNX1	4.15e-05	225	97	6	12168954
Pubmed	DUSP5 functions as a feedback regulator of TNFα-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes.	DUSP5 MAPK1	4.60e-05	4	97	2	29018280
Pubmed	Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3.	PGR MAPK1	4.60e-05	4	97	2	17081988
Pubmed	The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression.	PGR MAPK1	4.60e-05	4	97	2	20418913
Pubmed	Lycium barbarum Polysaccharides Promote Maturity of Murine Dendritic Cells through Toll-Like Receptor 4-Erk1/2-Blimp1 Signaling Pathway.	PRDM1 MAPK1	4.60e-05	4	97	2	33344654
Pubmed	HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier.	ABCC1 MAPK1	4.60e-05	4	97	2	16395283
Pubmed	Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes.	RASA1 NF1	4.60e-05	4	97	2	11246230
Pubmed	Activation of ERK and NF-κB during HARE-Mediated Heparin Uptake Require Only One of the Four Endocytic Motifs.	STAB2 MAPK1	4.60e-05	4	97	2	27100626
Pubmed	Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways.	HDAC6 PLAA	4.60e-05	4	97	2	11689694
Pubmed	B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: a mechanism of antigen-triggering plasma cell differentiation.	PRDM1 MAPK1	4.60e-05	4	97	2	22593617
Pubmed	Blood vascular abnormalities in Rasa1(R780Q) knockin mice: implications for the pathogenesis of capillary malformation-arteriovenous malformation.	RASA1 MAPK1	4.60e-05	4	97	2	25283357
Pubmed	Serotonin activates MAP kinase and PI3K/Akt signaling pathways in prostate cancer cell lines.	PIK3CG MAPK1	4.60e-05	4	97	2	19926313
Pubmed	NF1 tumor suppressor protein and mRNA in skeletal tissues of developing and adult normal mouse and NF1-deficient embryos.	NF1 MAPK1	4.60e-05	4	97	2	15125795
Pubmed	Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway.	PIK3CG MAPK1	4.60e-05	4	97	2	17410437
Pubmed	Nuclear matrix-associated protein SMAR1 regulates alternative splicing via HDAC6-mediated deacetylation of Sam68.	HDAC6 MAPK1	4.60e-05	4	97	2	26080397
Pubmed	Mutational analysis of sites in the translational regulator, PHAS-I, that are selectively phosphorylated by mTOR.	RORC MAPK1	4.60e-05	4	97	2	10405182
Pubmed	Decreased phosphorylation of protein kinase B and extracellular signal-regulated kinase in neutrophils from patients with myelodysplasia.	PIK3CG MAPK1	4.60e-05	4	97	2	12529294
Pubmed	Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120.	PIK3C2B PIK3CG MAPK1	4.63e-05	25	97	3	15689238
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	ABCC1 XPC PGR PTPN13 PIK3CG NFKBIA ZNF624	5.93e-05	351	97	7	20453000
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	VPS18 UACA VPS39 LRCH1 NF1	5.94e-05	147	97	5	29576527
Pubmed	Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity.	HDAC6 MAPK1	7.66e-05	5	97	2	29259132
Pubmed	Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.	PIK3CG NFKBIA	7.66e-05	5	97	2	27076174
Pubmed	Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat.	GNAT3 GNAT2	7.66e-05	5	97	2	15886333
Pubmed	Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.	RASA1 MAPK1	7.66e-05	5	97	2	8618896
Pubmed	Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma.	PIK3CG MAPK1	7.66e-05	5	97	2	19588500
Pubmed	TCF-1 controls ILC2 and NKp46+RORγt+ innate lymphocyte differentiation and protection in intestinal inflammation.	PRDM1 RORC	7.66e-05	5	97	2	24038093
Pubmed	Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1.	PIK3CG NFKBIA	7.66e-05	5	97	2	18515365
Pubmed	Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems.	NF1 MAPK1	7.66e-05	5	97	2	7499408
Pubmed	Neurofibromatosis-1 heterozygosity impairs CNS neuronal morphology in a cAMP/PKA/ROCK-dependent manner.	NF1 MAPK1	7.66e-05	5	97	2	21903164
Pubmed	Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling.	PIK3CG MAPK1	7.66e-05	5	97	2	19855431
Pubmed	Interferon alpha induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin.	PIK3CG MAPK1	7.66e-05	5	97	2	17942603
Pubmed	The hyaluronan receptor for endocytosis mediates hyaluronan-dependent signal transduction via extracellular signal-regulated kinases.	STAB2 MAPK1	7.66e-05	5	97	2	18387958
Pubmed	Cl- -channel is essential for LDL-induced cell proliferation via the activation of Erk1/2 and PI3k/Akt and the upregulation of Egr-1 in human aortic smooth muscle cells.	PIK3CG MAPK1	7.66e-05	5	97	2	18711316
Pubmed	Caveolin-1 interferes cell growth of lung cancer NCI-H446 cell through the interactions with phospho-ERK1/2, estrogen receptor and progestin receptor.	PGR MAPK1	7.66e-05	5	97	2	22564243
Pubmed	Neurofibromatosis type 1 alternative splicing is a key regulator of Ras/ERK signaling and learning behaviors in mice.	NF1 MAPK1	7.66e-05	5	97	2	28934393
Pubmed	Mig-6 Mouse Model of Endometrial Cancer.	PGR MAPK1	7.66e-05	5	97	2	27910070
Pubmed	IL-27 triggers IL-10 production in Th17 cells via a c-Maf/RORγt/Blimp-1 signal to promote the progression of endometriosis.	PRDM1 RORC	7.66e-05	5	97	2	28300844
Pubmed	Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling.	HDAC6 PGR	7.66e-05	5	97	2	18316616
Pubmed	Nf1 has an essential role in endothelial cells.	NF1 MAPK1	7.66e-05	5	97	2	12469121
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	UACA KALRN DOCK11 PREPL OPA1 ITIH1 NF1 SYNJ1 MAPK1 UNC79 GOLGB1	7.88e-05	963	97	11	28671696
Pubmed	New gene functions in megakaryopoiesis and platelet formation.	KALRN DOCK8 KIAA0232 PIK3CG	8.02e-05	81	97	4	22139419
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	CHERP HDAC6 NUP85 UACA HAUS3 XPC POF1B PLAA ASPM GNAT3 USP39 GNAT2	9.02e-05	1155	97	12	20360068
Pubmed	The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.	VPS18 VPS39 MAPK1	1.08e-04	33	97	3	33452816
Pubmed	HIV-1 Tat dysregulation of lipopolysaccharide-induced cytokine responses: microbial interactions in HIV infection.	NFKBIA MAPK1	1.15e-04	6	97	2	19622906
Pubmed	IκB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia.	PIK3CG MAPK1	1.15e-04	6	97	2	20671123
Pubmed	Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells.	PRDM1 RORC	1.15e-04	6	97	2	30282028
Pubmed	ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cells.	DUSP5 MAPK1	1.15e-04	6	97	2	17131384
Pubmed	FGF8 morphogen gradients are differentially regulated by heparan sulphotransferases Hs2st and Hs6st1 in the developing brain.	HS2ST1 MAPK1	1.15e-04	6	97	2	29158323
Pubmed	Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA.	EXOSC10 DIS3L2	1.15e-04	6	97	2	23756462
Pubmed	APOBEC3 versus Retroviruses, Immunity versus Invasion: Clash of the Titans.	APOBEC3D ULBP1	1.15e-04	6	97	2	22720156
Pubmed	Mapping of the mouse corticotropin-releasing hormone receptor 2 gene (Crhr2) to chromosome 6.	SMARCAD1 USP39	1.15e-04	6	97	2	9383293
Pubmed	Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo.	RASA1 PIK3C2B	1.15e-04	6	97	2	8084603
Pubmed	DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.	PGR MAPK1	1.15e-04	6	97	2	22031296
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	VPS39 SPG11 LRCH1 PREPL PSME4 HS2ST1 PCNX1 ZC3H7B	1.20e-04	529	97	8	14621295
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TTC28 DOCK11 KIAA0232 KIAA1671 PTPN13 NF1 SYNJ1 PIK3C2B TSSK1B GOLGB1	1.48e-04	861	97	10	36931259
Pubmed	Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways.	PIK3CG MAPK1	1.60e-04	7	97	2	19609946
Pubmed	RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking.	VPS18 VPS39	1.60e-04	7	97	2	25445562
Pubmed	CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks.	PIK3C2B PIK3CG	1.60e-04	7	97	2	18755982
Pubmed	2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline.	HS2ST1 MAPK1	1.60e-04	7	97	2	26075383
Pubmed	Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling.	NF1 MAPK1	1.60e-04	7	97	2	20661302
Pubmed	Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma.	RASA1 MAPK1	1.60e-04	7	97	2	21292498
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	VPS18 VPS39 PLA2G4B FRMD5	2.77e-04	147	97	4	chr15q15
GeneFamily	Phosphatidylinositol 3-kinase subunits	PIK3C2B PIK3CG	3.09e-04	8	61	2	831
Coexpression	GSE45365_WT_VS_IFNAR_KO_BCELL_MCMV_INFECTION_UP	RASA1 UACA DOCK11 PLAA ZNF624 ZC3H7B GOLGB1	5.65e-06	184	97	7	M9988
Coexpression	GSE4142_NAIVE_VS_GC_BCELL_UP	RASA1 UMODL1 PIK3CG B4GALNT2 PHF14 RORC ALPK2	9.44e-06	199	97	7	M6375
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK11 DOCK8 ABCA13 PIK3C2B TLE3 PCNX1	2.34e-06	175	97	6	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2-Excitatory_Neuron.Slc17a7.Tac2.Htr2c_(Lateral_habenula)\|Thalamus / BrainAtlas - Mouse McCarroll V32	STAB2 NAA60 ABHD10 UMODL1 ANKRD61	2.56e-06	99	97	5	3dd31ed90bd1655cad954045afaef50de889008b
ToppCell	COVID-19-Heart-Lymph_EC\|Heart / Disease (COVID-19 only), tissue and cell type	STAB2 KALRN DOCK8 PKHD1L1 KIAA1671 GNAT3	2.67e-06	179	97	6	411620201a860716a8773b92f50f7b94ef34a586
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_4\|COVID-19_Convalescent / Disease condition and Cell class	MIER2 ABCC1 DUSP5 LRCH1 NF1 ZNF445	2.67e-06	179	97	6	366e4a31db9e80fd1770ac9f1ae148fefeb9f7df
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	STAB2 KALRN PKHD1L1 POF1B KIAA1671 GNAT3	3.23e-06	185	97	6	f9f48251bc33eb6bf2cff580d1a3207d21450aa0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RASA1 HAUS3 PRDM1 PTPN13 PCNX1	3.25e-05	167	97	5	83969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell	Tuft-tuft-4\|World / Class top	ANO4 C2orf69 KALRN PRDM1 GNAT3	3.95e-05	174	97	5	d6f306ebf66061bf9e9742000bfedce12d277452
ToppCell	Control-Neuronal_cells-Neuronal_cells\|Control / group, cell type (main and fine annotations)	STAB2 KALRN PKHD1L1 KIAA1671 GNAT3	4.17e-05	176	97	5	98c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCell	Control-Neuronal_cells\|Control / group, cell type (main and fine annotations)	STAB2 KALRN PKHD1L1 KIAA1671 GNAT3	4.17e-05	176	97	5	c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCell	COVID-19-Heart-Lymph_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	STAB2 KALRN PKHD1L1 POF1B GNAT3	4.28e-05	177	97	5	326fde0734ef0d7272693966d346ca479b9d8147
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_4\|Classical_Monocyte / Disease condition and Cell class	MIER2 DUSP5 LRCH1 NF1 ZNF445	4.52e-05	179	97	5	9d51318ac198a8801bd5c7031ebf2b0c74ffeeb6
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_memory-B_memory-0\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HLA-DPB1 PKHD1L1 TLE3 GNAT2 UNC79	4.52e-05	179	97	5	fce1ba53815145f6248d4e90aedca3dad84e33e4
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANO4 DOCK11 PRDM1 ASPM FRMD5	4.89e-05	182	97	5	a3c5c0eff527c8d3848acda14af8f9e99c69b0de
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	STAB2 DUSP5 PKHD1L1 KIAA1671 PIK3C2B	5.02e-05	183	97	5	bc98df870de65aff6dab295c24cbc199c7f2aa15
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 KALRN ABCA13 PKHD1L1 UNC79	5.15e-05	184	97	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 KALRN ABCA13 PKHD1L1 UNC79	5.15e-05	184	97	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 KALRN ABCA13 PKHD1L1 UNC79	5.15e-05	184	97	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID-19-Neuronal_cells-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	STAB2 KALRN PKHD1L1 KIAA1671 GNAT3	5.28e-05	185	97	5	4a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	STAB2 DOCK8 PKHD1L1 KIAA1671 GNAT3	5.28e-05	185	97	5	3be9e05b929ac4d956b1d53284072f668a6c1959
ToppCell	COVID-19-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	STAB2 KALRN PKHD1L1 KIAA1671 GNAT3	5.28e-05	185	97	5	36ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-lymphatic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	STAB2 DOCK8 PKHD1L1 KIAA1671 GNAT3	5.28e-05	185	97	5	c3dd64a726cb8a1fe048683c266b7532a714a52e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANO4 DOCK11 PRDM1 ASPM FRMD5	5.42e-05	186	97	5	6379609b7ace80683f5754b16aa77f11b43766ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TTC28 DOCK11 DOCK8 FRMD5 ALPK2	5.56e-05	187	97	5	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	Endothelial-endothelial_cell_of_lymph_vessel\|World / Lineage, Cell type, age group and donor	STAB2 KALRN PKHD1L1 KIAA1671 GNAT3	5.70e-05	188	97	5	80910dcbb51990f2baed240f319456c0d3fa2065
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel\|Children_(3_yrs) / Lineage, Cell type, age group and donor	STAB2 KALRN PKHD1L1 KIAA1671 GNAT3	5.70e-05	188	97	5	c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-Trm_Th1/Th17\|lymph-node_spleen / Manually curated celltypes from each tissue	DUSP5 PRDM1 PTPN13 NFKBIA RORC	5.70e-05	188	97	5	a20521198c6db17589535fb439533329582c9dd2
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	STAB2 KALRN PKHD1L1 KIAA1671 GNAT3	5.70e-05	188	97	5	2db80767903703e7e0a1a37c598f7877a909ee94
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	STAB2 KALRN DUSP5 PKHD1L1 KIAA1671	5.85e-05	189	97	5	0d18ea72bd58d32a8ab9a61cf97f5786642f804b
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	STAB2 KALRN DUSP5 PKHD1L1 KIAA1671	5.85e-05	189	97	5	55a1776a4ce049959b3f13a43744c7314bc1f00a
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANO4 DOCK11 PRDM1 ASPM FRMD5	5.99e-05	190	97	5	8c9c230a509afaeee50644153974a5642b01a2b8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMARCAD1 POF1B PSME4 B4GALNT2 GOLGB1	6.15e-05	191	97	5	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMARCAD1 POF1B PSME4 B4GALNT2 GOLGB1	6.15e-05	191	97	5	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	ILEUM-inflamed-(1)_T_cell-(1)_Th17_Trm\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DUSP5 PRDM1 PTPN13 NFKBIA ATF7IP2	6.30e-05	192	97	5	12f7ea575da5d650c740e6060f5dab0478e563dd
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANO4 DOCK11 PRDM1 ASPM FRMD5	6.46e-05	193	97	5	5581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MIER2 KALRN HLA-DPB1 DUSP5 PKHD1L1	6.61e-05	194	97	5	cf9cf115dbbb9997f7c303ae07f42f3d80ff9a21
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UACA GRB7 KIAA1671 PREP ASPM	6.61e-05	194	97	5	8ef0b71fef5b84cfd04973f891215333e7035d1d
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-Trm_Th1/Th17\|lymph-node_spleen / Manually curated celltypes from each tissue	DUSP5 PRDM1 PTPN13 NFKBIA RORC	6.78e-05	195	97	5	c60982804a74dbe6607c021799ca74af2204aba8
ToppCell	Control-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	ABCC1 RASA1 PRDM1 PTPN13 PCNX1	6.78e-05	195	97	5	6687e579582d7a239bee80846de0cf827a6f6a62
ToppCell	IPF-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	ABCC1 PRDM1 PTPN13 NFKBIA PCNX1	6.94e-05	196	97	5	6e70c48a63d9673eb16b0847c1bd88eecc2f7a3c
ToppCell	moderate-Lymphoid-Treg\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PRDM1 PTPN13 NFKBIA ATF7IP2 RORC	6.94e-05	196	97	5	9152f4a8a27ff4ee28f231c5ad00eb2edd9ea6da
ToppCell	Endothelial\|World / Lineage, Cell type, age group and donor	STAB2 UACA KALRN PKHD1L1 KIAA1671	6.94e-05	196	97	5	96c6d78482a130ce4e29f6629972a06d10d7530e
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-T_lymphocytic-type_I_NK_T_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DUSP5 PRDM1 PTPN13 NFKBIA PCNX1	7.11e-05	197	97	5	51340570667914bffec741c72a8d09cc46abb8e8
ToppCell	moderate-Epithelial-Squamous\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DUSP5 GRB7 PRDM1 RPTN NFKBIA	7.11e-05	197	97	5	2e13881f917d4f62a5b3e968e41c57e43300d988
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-Trm_Th1/Th17\|GI_small-bowel / Manually curated celltypes from each tissue	DUSP5 PTPN13 NFKBIA ATF7IP2 RORC	7.28e-05	198	97	5	f4fc0cac858fc6dcd779d7959ccec51f78ea8cc2
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STAB2 KALRN PKHD1L1 KIAA1671 GNAT3	7.28e-05	198	97	5	b3a020522e064bb61949d38e442f24026e339364
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STAB2 KALRN PKHD1L1 KIAA1671 GNAT3	7.28e-05	198	97	5	fc4b7c3ad52bc5c8b40fa04a156bfbb58afa2872
ToppCell	mild-MAIT\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PRDM1 NFKBIA ATF7IP2 RORC GOLGB1	7.46e-05	199	97	5	cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCell	severe-CD4+_Tcm\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DUSP5 HAUS3 PRDM1 NFKBIA ATF7IP2	7.64e-05	200	97	5	e83558090a079dd9e40e0d3b5d9917fbd2695ec4
Disease	hepatitis B (is_implicated_in)	DOCK8 HLA-DPB1 NFKBIA	2.18e-04	37	93	3	DOID:2043 (is_implicated_in)
Disease	eosinophil count	CHERP NAA60 UACA HLA-DPB1 KIAA0232 SLC9C1 TRMT10C PIK3C2B TLE3 NFKBIA PCNX1 UBAC2 ZC3H7B ALPK2	2.29e-04	1488	93	14	EFO_0004842
Disease	McCune Albright syndrome (implicated_via_orthology)	GNAT3 GNAT2	2.72e-04	8	93	2	DOID:1858 (implicated_via_orthology)
Disease	Basal cell carcinoma	RASA1 XPC	5.31e-04	11	93	2	C0007117
Disease	eosinophil percentage of leukocytes	NAA60 HLA-DPB1 TRMT10C PIK3C2B TLE3 NFKBIA UBAC2 ZC3H7B ALPK2	5.84e-04	746	93	9	EFO_0007991
Disease	Squamous cell carcinoma	RASA1 DOCK8 XPC MAPK1	6.50e-04	124	93	4	C0007137
Disease	childhood onset asthma	HLA-DPB1 NFKBIA MKLN1 UBAC2 PHF14 RORC	6.71e-04	334	93	6	MONDO_0005405
Disease	Asthma, Aspirin-Induced	HLA-DPB1 MS4A2	7.49e-04	13	93	2	C1319853
Disease	neutrophil percentage of granulocytes	SLC9C1 TRMT10C NFKBIA UBAC2 ZC3H7B	7.89e-04	228	93	5	EFO_0007994
Disease	eosinophil percentage of granulocytes	HLA-DPB1 TRMT10C NFKBIA UBAC2 ZC3H7B	8.86e-04	234	93	5	EFO_0007996
Disease	osteoarthritis, hip, osteoarthritis, knee	HLA-DPB1 ITIH1 NF1	1.00e-03	62	93	3	EFO_0004616, EFO_1000786
Disease	endometriosis (biomarker_via_orthology)	PGR NFKBIA	1.15e-03	16	93	2	DOID:289 (biomarker_via_orthology)
Disease	Colorectal Carcinoma	ABCC1 VPS18 KALRN ABCA13 NF1 B4GALNT2 ZNF624 FBXL2	1.70e-03	702	93	8	C0009402
Disease	Disease Exacerbation	ABCC1 ABCA13 XPC PREP	1.87e-03	165	93	4	C0235874
Disease	Noonan Syndrome	RASA1 NF1	2.59e-03	24	93	2	C0028326
Disease	feeling nervous measurement	ITIH1 NF1 ZC3H7B	2.65e-03	87	93	3	EFO_0009597
Disease	age at menopause	ZNF729 TTC28 OPA1 PGR PIK3CG	2.71e-03	302	93	5	EFO_0004704
Disease	atopic dermatitis (is_implicated_in)	DOCK8 MS4A2	3.04e-03	26	93	2	DOID:3310 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
HHLKILSPIYCAFQN	UMODL1	1071	Q5DID0
HQKYIRECLAQAIFH	ERICH3	61	Q5RHP9
NLKKSLAYIHIHSCQ	MS4A2	151	Q01362
HIFYFHFKNLLKACG	APOBEC3D	211	Q96AK3
HLHKFSCYDNFVKSN	C2orf69	156	Q8N8R5
FKLALHYFKNHLQCA	B4GALNT2	551	Q8NHY0
NQYIHVLHLSCCTKN	ALPK2	66	Q86TB3
CFYLAHELHLNLLNH	FBXO4	341	Q9UKT5
LQHHNLLVCHVTDFY	HLA-DPB1	136	P04440
ANQHCTVSDHLKLYF	ABCA13	4961	Q86UQ4
HLAAKYHKAQSLLCL	ANKRD61	81	A6NGH8
YHKAQSLLCLLRHGA	ANKRD61	86	A6NGH8
FEHLVFCIKHLISYL	ANO4	891	Q32M45
YCNALALRSHHFQKV	DIS3L2	796	Q8IYB7
YRAHLCTKHHLQFLQ	ASPM	2296	Q8IZT6
DGLNKTTACYHHLVL	RGS9BP	11	Q6ZS82
LLKLHYCRSNIIDHF	OR6C1	161	Q96RD1
LQKELHVVYALSHVC	RASA1	731	P20936
LKTQHLSNDHICYFL	MAPK1	116	P28482
KHIQNYCHELVSLNL	FBXL2	201	Q9UKC9
SLKLLAAHCFIQHQY	NRBP2	311	Q9NSY0
SLHLFNSICNHKYFS	GNAT3	246	A8MTJ3
AFASKHHVAKCQNYL	KIAA1671	1331	Q9BY89
KICDLLVANNHFAHF	ITIH1	266	P19827
HCKAIYLHVLTTNNT	NAA60	131	Q9H7X0
HCFSHPLLKTLEYNQ	PCNX1	1321	Q96RV3
HGLCISNNNLHKTYL	KIAA0232	446	Q92628
LDHCKLLQSHNLYFG	NUP85	381	Q9BW27
LCAIDIHNKTLYHIT	ERG28	66	Q9UKR5
LQYLHNCRVAHLDIK	KALRN	2791	O60229
FLLYVRVAHTSKCHQ	LMLN2	186	A0A1B0GTW7
LCHFVSLEILNLYHN	LRCH1	116	Q9Y2L9
LKATNYNGHTCLHLA	NFKBIA	176	P25963
VDKLLHLTHYNVCNN	PLA2G4B	746	P0C869
ATLLYIHKLCHVFFT	EXOC8	451	Q8IYI6
RKNTDLYHCLLEHLQ	POF1B	266	Q8WVV4
DQHLLLLCDTCKLHY	PHF14	736	O94880
GFVLSLCHLQKVKHY	GRB7	466	Q14451
CCQAYNLIRKHTHLF	PIK3C2B	1261	O00750
HDLVKQLHLYCLNTF	PGR	881	P06401
LCYLHDVKNILQLHD	PREP	351	P48147
YRRHFLKTALNHCNL	OPA1	841	O60313
DAKGQYLFDLLCHHL	FRMD5	36	Q7Z6J6
YLFDLLCHHLNLLEK	FRMD5	41	Q7Z6J6
LCHHLNLLEKDYFGI	FRMD5	46	Q7Z6J6
HSLDHLLKLYCNVDS	EXOSC10	401	Q01780
QHELHFQAATYLCLL	FMC1	56	Q96HJ9
CSDLLKAAHRYVLQH	KLHL17	206	Q6TDP4
LKLQDCYAQLSHAHV	BPIFC	156	Q8NFQ6
KFEFLQTICNHEHYI	DOCK11	1066	Q5JSL3
FLRILCSHEHYLNLN	DOCK8	1096	Q8NF50
YLINDVLHHCQRKQA	CHERP	216	Q8IWX8
CCTLHQLYLQIHSKF	C1orf112	271	Q9NSG2
QLAYICAQHQLIHLK	HAUS3	266	Q68CZ6
YHLFLCHENSNNKLI	ATF7IP2	611	Q5U623
CQAYVHHQALLDVKN	HDAC6	1186	Q9UBN7
AYHASKCEFLANLHI	DUSP5	191	Q16690
HNKLHGITFLTRNYC	LRRC72	76	A6NJI9
DLSNLHLNRHCEKIY	MIER2	206	Q8N344
SKICQYLLHLCSYQH	PTPN13	851	Q12923
LQTLVLHQYFHICFV	ABCC1	376	P33527
LNVIYHSELKHTNYC	SLC9C1	636	Q4G0N8
HVLCKQYRHINNFQL	SMARCAD1	831	Q9H4L7
HHVFLNLHTLKFYCL	USP39	161	Q53GS9
NQSLHLHLKHYGVNC	SYNJ1	161	O43426
AIRLCLKHFRQHNYT	MKLN1	176	Q9UL63
ICNKAFHQVYNLTFH	FEZF1	376	A0PJY2
HNILKKYHQFIVECH	PIP4K2B	161	P78356
KYHQFIVECHGNTLL	PIP4K2B	166	P78356
SLHLFNSICNHKFFA	GNAT2	246	P19087
LCAKNKYHVLHINTT	HS2ST1	96	Q7LGA3
QCHKNYIHLCSLKVH	PRDM1	691	O75626
NVQYSFIKEAEHHCL	ABHD10	216	Q9NUJ1
DICVKAYLALRHHTN	PIK3CG	1011	P48736
QFILYCLEHSLQHLL	SPG11	991	Q96JI7
CEKAFHYRSLLIQHQ	ZNF624	281	Q9P2J8
FYFHQHLCILKAKLG	SENP5	31	Q96HI0
QLQYNLELAFHHHLC	RORC	441	P51449
FKEAICSSLKAYNHH	VPS18	801	Q9P253
CSSLKAYNHHIQELQ	VPS18	806	Q9P253
ALNYSVCFHKDHNIE	PLAA	706	Q9Y263
HCLYQATCHSLLNKA	NF1	1366	P21359
YHVVACHQLLLENLK	STAB2	1661	Q8WWQ8
KDHCVLFLKHSNLLY	PREPL	356	Q4J6C6
KHCELNNHLYKDQFL	PKHD1L1	3886	Q86WI1
KHAECLLDLNSHSLY	UNQ9370/PRO34162	106	Q6UXP9
KQGYTLSCNLLHHLL	PSME4	711	Q14997
LHLHESCVLSLKFAY	TLE3	696	Q04726
HLAAKYGHALCLQKL	UACA	106	Q9BZF9
LHKTHLCIAQELSDY	TTC28	496	Q96AY4
AYHQRLHTQEKAFKC	ZNF445	501	P59923
KFHQLSLAIKYCHDL	TSSK1B	116	Q9BXA7
FLHYDCVNHKAKAFA	ULBP1	61	Q9BZM6
HVKIHRCNESFIYLL	TBCCD1	331	Q9NVR7
HCQKLFVYDLHAVKN	UBAC2	36	Q8NBM4
HKVHLLCLLANGFYR	XPC	206	Q01831
LVQACYHKLDNKSHG	RPTN	81	Q6XPR3
FHIYFCNLKIDGALH	TRMT10C	241	Q7L0Y3
LLLQGHHDKVQSLCY	WDFY1	236	Q8IWB7
HHIKNLYAFNLFCQK	VPS39	346	Q96JC1
AFIQCSYLIRHKTIH	ZNF729	1196	A6NN14
KNHLLKYSLAHAFCC	UNC79	1081	Q9P2D8
AKHSFYNNKCLVHIV	ZC3H7B	581	Q9UGR2
HHKINCFFYLEKQLC	UNQ6126/PRO20091	81	Q6UXV3
QHYGDLLNHCAVLEK	GOLGB1	3081	Q14789
DKQYFCRTHLGHLLN	NMD3	356	Q96D46