Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane transporter activity

ANO4 TMEM63C SLC35B2 SLC22A25 GJB7 COX4I2 NOX5 ANO6 SLC20A2 KCNJ3 SLC44A3 SLC22A10

1.28e-0711803212GO:0022857
GeneOntologyMolecularFunctiontransporter activity

ANO4 TMEM63C SLC35B2 SLC22A25 GJB7 COX4I2 NOX5 ANO6 SLC20A2 KCNJ3 SLC44A3 SLC22A10

3.35e-0712893212GO:0005215
GeneOntologyMolecularFunctionshort-chain fatty acid transmembrane transporter activity

SLC22A25 SLC22A10

2.48e-055322GO:0015636
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

ANO4 TMEM63C COX4I2 NOX5 ANO6 SLC20A2 KCNJ3

1.62e-04758327GO:0015318
GeneOntologyMolecularFunctionchannel activity

ANO4 TMEM63C GJB7 NOX5 ANO6 KCNJ3

1.63e-04525326GO:0015267
GeneOntologyMolecularFunctionsuperoxide-generating NAD(P)H oxidase activity

DUOX2 NOX5

1.63e-0412322GO:0016175
GeneOntologyMolecularFunctiontoxin transmembrane transporter activity

SLC22A25 SLC22A10

1.63e-0412322GO:0019534
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

ANO4 TMEM63C GJB7 NOX5 ANO6 KCNJ3

1.64e-04526326GO:0022803
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

ANO4 TMEM63C COX4I2 NOX5 ANO6 SLC20A2 KCNJ3

2.14e-04793327GO:0015075
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

ANO4 TMEM63C ANO6 KCNJ3

2.46e-04193324GO:0015276
GeneOntologyMolecularFunctionlipid transporter activity

ANO4 SLC22A25 ANO6 SLC22A10

2.61e-04196324GO:0005319
GeneOntologyMolecularFunctionligand-gated channel activity

ANO4 TMEM63C ANO6 KCNJ3

2.66e-04197324GO:0022834
GeneOntologyMolecularFunctionsodium-independent organic anion transmembrane transporter activity

SLC22A25 SLC22A10

3.75e-0418322GO:0015347
GeneOntologyMolecularFunctionintracellularly calcium-gated chloride channel activity

ANO4 ANO6

4.64e-0420322GO:0005229
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

DUOX2 NOX5

4.64e-0420322GO:0050664
GeneOntologyMolecularFunctionintracellularly calcium-gated channel activity

ANO4 ANO6

4.64e-0420322GO:0141147
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

TMEM63C COX4I2 NOX5 ANO6 SLC20A2 KCNJ3

5.72e-04664326GO:0008324
GeneOntologyMolecularFunctionfatty acid transmembrane transporter activity

SLC22A25 SLC22A10

6.16e-0423322GO:0015245
GeneOntologyMolecularFunctionphospholipid scramblase activity

ANO4 ANO6

6.16e-0423322GO:0017128
GeneOntologyMolecularFunctionmonoatomic ion channel activity

ANO4 TMEM63C NOX5 ANO6 KCNJ3

7.57e-04459325GO:0005216
GeneOntologyMolecularFunctioncalcium-activated cation channel activity

TMEM63C ANO6

8.52e-0427322GO:0005227
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC35B2 SLC22A25 COX4I2 SLC20A2 SLC22A10

9.00e-04477325GO:0022804
GeneOntologyMolecularFunctionbeta-catenin binding

CDH24 CDH20 CDH12

9.24e-04120323GO:0008013
GeneOntologyMolecularFunctioncalcium ion binding

CAPN13 DUOX2 CDH24 CDH20 NOX5 CDH12

1.07e-03749326GO:0005509
GeneOntologyMolecularFunctionmonoatomic ion-gated channel activity

TMEM63C ANO6

1.12e-0331322GO:0022839
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC35B2 SLC22A25 SLC20A2 SLC22A10

1.23e-03296324GO:0015291
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

TMEM63C ANO6 KCNJ3

1.44e-03140323GO:0099094
GeneOntologyMolecularFunctiongated channel activity

ANO4 TMEM63C ANO6 KCNJ3

1.91e-03334324GO:0022836
GeneOntologyMolecularFunctionmonoatomic cation channel activity

TMEM63C NOX5 ANO6 KCNJ3

2.10e-03343324GO:0005261
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

ANO4 ANO6 SLC20A2

2.55e-03171323GO:0015103
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

ANO4 ANO6

2.91e-0350322GO:0099095
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

TMEM63C COX4I2 NOX5 SLC20A2 KCNJ3

3.00e-03627325GO:0022890
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ANO4 ANO6

3.02e-0351322GO:0140303
GeneOntologyMolecularFunctionlipid transmembrane transporter activity

SLC22A25 SLC22A10

6.09e-0373322GO:0170055
GeneOntologyMolecularFunctionphospholipid transporter activity

ANO4 ANO6

6.25e-0374322GO:0005548
GeneOntologyMolecularFunctionchloride channel activity

ANO4 ANO6

8.36e-0386322GO:0005254
GeneOntologyMolecularFunctionmonocarboxylic acid transmembrane transporter activity

SLC22A25 SLC22A10

9.13e-0390322GO:0008028
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H

DUOX2 NOX5

1.01e-0295322GO:0016651
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC35B2 SLC22A25 SLC22A10

1.13e-02293323GO:0008514
GeneOntologyMolecularFunctionmonoatomic anion channel activity

ANO4 ANO6

1.18e-02103322GO:0005253
GeneOntologyMolecularFunctioncadherin binding

CDH24 CDH20 CDH12

1.67e-02339323GO:0045296
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

ANO4 ANO6

1.71e-02125322GO:0015108
GeneOntologyBiologicalProcesscalcium activated phosphatidylserine scrambling

ANO4 ANO6

1.22e-054302GO:0061589
GeneOntologyBiologicalProcessmonoatomic ion transport

ANO4 TMEM63C SLC22A25 COX4I2 NOX5 ANO6 SLC20A2 KCNJ3 HECW2 SLC22A10

1.46e-0513743010GO:0006811
GeneOntologyBiologicalProcesscalcium activated phospholipid scrambling

ANO4 ANO6

2.04e-055302GO:0061588
GeneOntologyBiologicalProcesscalcium activated phosphatidylcholine scrambling

ANO4 ANO6

2.04e-055302GO:0061590
GeneOntologyBiologicalProcesscalcium activated galactosylceramide scrambling

ANO4 ANO6

2.04e-055302GO:0061591
GeneOntologyBiologicalProcessendomembrane system organization

ANO4 ARFGEF1 HUWE1 NOX5 ANO6 YIPF4 FER1L4

4.00e-05672307GO:0010256
GeneOntologyBiologicalProcesscell-cell adhesion mediated by cadherin

CDH24 CDH20 CDH12

5.20e-0550303GO:0044331
GeneOntologyBiologicalProcesscalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

CDH24 CDH20 CDH12

6.19e-0553303GO:0016339
GeneOntologyBiologicalProcessadherens junction organization

CDH24 CDH20 CDH12

9.44e-0561303GO:0034332
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

ANO4 TMEM63C COX4I2 NOX5 ANO6 SLC20A2 KCNJ3 HECW2

1.43e-041115308GO:0034220
GeneOntologyBiologicalProcessplasma membrane organization

ANO4 NOX5 ANO6 FER1L4

1.52e-04188304GO:0007009
GeneOntologyBiologicalProcesspositive regulation of wound healing

ARFGEF1 DUOX2 ANO6

1.61e-0473303GO:0090303
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

TMEM63C COX4I2 NOX5 ANO6 SLC20A2 KCNJ3 HECW2

3.28e-04942307GO:0098655
GeneOntologyBiologicalProcesspositive regulation of response to wounding

ARFGEF1 DUOX2 ANO6

3.30e-0493303GO:1903036
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

ANO4 COX4I2 NOX5 ANO6 SLC20A2 KCNJ3 HECW2

5.21e-041017307GO:0098660
GeneOntologyBiologicalProcessplasma membrane phospholipid scrambling

ANO4 ANO6

6.50e-0426302GO:0017121
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

ANO4 ANO6 SLC20A2

9.57e-04134303GO:0098661
GeneOntologyBiologicalProcessmonoatomic cation transport

TMEM63C COX4I2 NOX5 ANO6 SLC20A2 KCNJ3 HECW2

1.12e-031157307GO:0006812
GeneOntologyBiologicalProcessbone mineralization

DUOX2 ANO6 SLC20A2

1.30e-03149303GO:0030282
GeneOntologyBiologicalProcessorganophosphate ester transport

ANO4 SLC35B2 ANO6

1.65e-03162303GO:0015748
GeneOntologyBiologicalProcessregulation of wound healing

ARFGEF1 DUOX2 ANO6

1.77e-03166303GO:0061041
GeneOntologyBiologicalProcessmembrane organization

ANO4 HUWE1 NOX5 ANO6 YIPF4 FER1L4

1.77e-03914306GO:0061024
GeneOntologyBiologicalProcesscell-cell junction assembly

CDH24 CDH20 CDH12

1.80e-03167303GO:0007043
GeneOntologyBiologicalProcessGolgi organization

ARFGEF1 HUWE1 YIPF4

1.83e-03168303GO:0007030
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

COX4I2 NOX5 ANO6 SLC20A2 KCNJ3 HECW2

1.85e-03922306GO:0098662
GeneOntologyCellularComponentcatenin complex

CDH24 CDH20 CDH12

1.57e-0532323GO:0016342
GeneOntologyCellularComponentplasma membrane protein complex

DUOX2 CDH24 GJB7 CDH20 NOX5 PSENEN KCNJ3 CDH12

1.80e-05785328GO:0098797
GeneOntologyCellularComponentmembrane protein complex

DUOX2 CDH24 GJB7 CDH20 COX4I2 NOX5 PSENEN ANO6 KCNJ3 CDH12

5.19e-0514983210GO:0098796
GeneOntologyCellularComponentNADPH oxidase complex

DUOX2 NOX5

3.42e-0418322GO:0043020
GeneOntologyCellularComponentextrinsic component of plasma membrane

CDH24 CDH20 CDH12

1.19e-03137323GO:0019897
GeneOntologyCellularComponentoxidoreductase complex

DUOX2 COX4I2 NOX5

1.89e-03161323GO:1990204
DomainCadherin_C

CDH24 CDH20 CDH12

9.29e-0625313PF01049
DomainCadherin_cytoplasmic-dom

CDH24 CDH20 CDH12

9.29e-0625313IPR000233
DomainCatenin_binding_dom

CDH24 CDH20 CDH12

1.47e-0529313IPR027397
Domain-

CDH24 CDH20 CDH12

1.47e-05293134.10.900.10
DomainAnoct_dimer

ANO4 ANO6

5.57e-057312PF16178
DomainNAD_binding_6

DUOX2 NOX5

5.57e-057312PF08030
DomainAnoct_dimer

ANO4 ANO6

5.57e-057312IPR032394
DomainFAD-bd_8

DUOX2 NOX5

5.57e-057312IPR013112
DomainFe_red_NAD-bd_6

DUOX2 NOX5

5.57e-057312IPR013121
DomainFAD_binding_8

DUOX2 NOX5

5.57e-057312PF08022
DomainAnoctamin

ANO4 ANO6

1.19e-0410312PF04547
DomainAnoctamin

ANO4 ANO6

1.19e-0410312IPR007632
DomainFe3_Rdtase_TM_dom

DUOX2 NOX5

1.74e-0412312IPR013130
DomainFerric_reduct

DUOX2 NOX5

1.74e-0412312PF01794
DomainFd_Rdtase_FAD-bd

DUOX2 NOX5

4.48e-0419312IPR017927
DomainFAD_FR

DUOX2 NOX5

4.48e-0419312PS51384
DomainRiboflavin_synthase-like_b-brl

DUOX2 NOX5

4.48e-0419312IPR017938
DomainCadherin_CS

CDH24 CDH20 CDH12

7.72e-04109313IPR020894
DomainCadherin

CDH24 CDH20 CDH12

8.57e-04113313PF00028
DomainCADHERIN_1

CDH24 CDH20 CDH12

8.57e-04113313PS00232
Domain-

CDH24 CDH20 CDH12

8.79e-041143132.60.40.60
DomainCADHERIN_2

CDH24 CDH20 CDH12

8.79e-04114313PS50268
DomainCA

CDH24 CDH20 CDH12

9.01e-04115313SM00112
DomainHECT

HUWE1 HECW2

9.12e-0427312PF00632
DomainHECTc

HUWE1 HECW2

9.12e-0427312SM00119
DomainHECT_dom

HUWE1 HECW2

9.12e-0427312IPR000569
DomainHECT

HUWE1 HECW2

9.12e-0427312PS50237
DomainCadherin-like

CDH24 CDH20 CDH12

9.24e-04116313IPR015919
DomainCadherin

CDH24 CDH20 CDH12

9.71e-04118313IPR002126
DomainEF_HAND_2

CAPN13 DUOX2 NOX5

6.50e-03231313PS50222
DomainMFS

SLC22A25 SLC22A10

7.22e-0377312IPR011701
DomainMFS_1

SLC22A25 SLC22A10

7.22e-0377312PF07690
Domain-

CAPN13 DUOX2 NOX5

9.08e-032613131.10.238.10
DomainEF-hand-dom_pair

CAPN13 DUOX2 NOX5

1.17e-02287313IPR011992
DomainMFS

SLC22A25 SLC22A10

1.38e-02108312PS50850
DomainMFS_dom

SLC22A25 SLC22A10

2.07e-02134312IPR020846
Pubmed

Comparative analysis of type II classic cadherin mRNA distribution patterns in the developing and adult mouse somatosensory cortex and hippocampus suggests significant functional redundancy.

CDH24 CDH20 CDH12

1.55e-071232322102170
Pubmed

Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse.

CDH24 CDH20 CDH12

3.19e-071532333833667
Pubmed

Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney.

SLC22A25 SLC22A10

2.46e-06332220332632
Pubmed

Identification of a novel murine organic anion transporter like protein 1 (OATLP1) expressed in the kidney.

SLC22A25 SLC22A10

2.46e-06332217079864
Pubmed

Characterization of mouse organic anion transporter 5 as a renal steroid sulfate transporter.

SLC22A25 SLC22A10

2.46e-06332216150593
Pubmed

Renal expression of organic anion transporter Oat5 in rats and mice exhibits the female-dominant sex differences.

SLC22A25 SLC22A10

2.46e-06332220865662
Pubmed

Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members.

SLC22A25 SLC22A10

4.92e-06432219417012
Pubmed

Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney.

SLC22A25 SLC22A10

4.92e-06432215068970
Pubmed

Identification and characterization of TMEM16E and TMEM16F genes in silico.

ANO4 ANO6

1.23e-05632215067359
Pubmed

ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.

ANO4 ANO6

1.72e-05732222075693
Pubmed

Anoctamins are a family of Ca2+-activated Cl- channels.

ANO4 ANO6

2.29e-05832222946059
Pubmed

Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.

ANO4 ANO6

3.67e-051032223532839
Pubmed

Structure and function of TMEM16 proteins (anoctamins).

ANO4 ANO6

3.67e-051032224692353
Pubmed

Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.

ANO4 ANO6

3.67e-051032219015192
Pubmed

Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa.

SLC22A25 SLC22A10

6.36e-051332215369770
Pubmed

Molecular physiology of renal organic anion transporters.

SLC22A25 SLC22A10

6.36e-051332216403838
Pubmed

Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys.

SLC22A25 SLC22A10

9.76e-051632219679677
Pubmed

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.

CDH24 CDH12

1.54e-04203227806582
Pubmed

Type II cadherins guide assembly of a direction-selective retinal circuit.

CDH24 CDH12

2.24e-042432225126785
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

HUWE1 HECW2

2.63e-042632226949039
Pubmed

Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring.

CDH20 CDH12

2.63e-042632239152101
Pubmed

Phrenic-specific transcriptional programs shape respiratory motor output.

CDH20 CDH12

2.84e-042732231944180
Pubmed

Motor neuron position and topographic order imposed by β- and γ-catenin activities.

CDH20 CDH12

3.28e-042932222036570
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

ARFGEF1 PTDSS2 HUWE1 OPN3 ANO6 YIPF4

3.65e-04106132633845483
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

ARFGEF1 PTDSS2 SLC35B2 ANO6 YIPF4 CLPTM1

7.02e-04120132635696571
Cytoband11q12.3

SLC22A25 SLC22A10

3.26e-043832211q12.3
GeneFamilyCD molecules|Type II classical cadherins

CDH24 CDH20 CDH12

5.83e-07132431186
GeneFamilyAnoctamins

ANO4 ANO6

7.55e-0510242865
GeneFamilySolute carriers

SLC35B2 SLC22A25 SLC20A2 SLC44A3 SLC22A10

1.46e-04395245752
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

SFI1 OPN3

2.38e-02181242694
GeneFamilyEF-hand domain containing

DUOX2 NOX5

3.38e-02219242863
Diseaseestrogen measurement

SLC22A25 SLC22A10

4.78e-0510312EFO_0011007
Diseaseandrosterone glucuronide measurement

SLC22A25 YIPF4

2.01e-0420312EFO_0800317
Diseasegranulocyte colony-stimulating factor measurement

ANO4 CLPTM1

5.87e-0434312EFO_0008142
Diseasepyruvate measurement

CAPN13 CDH20 CDH12

2.76e-03268313EFO_0010117
Diseaseneonatal abstinence syndrome

SLC22A25 CDH12

2.98e-0377312EFO_0005799
Diseasecreatinine measurement, glomerular filtration rate

PHTF2 CDH20

6.72e-03117312EFO_0004518, EFO_0005208
Diseaseenergy intake

PHTF2 CDH20

8.73e-03134312EFO_0003939
Diseaseobsolete_red blood cell distribution width

DUOX2 CDH24 HECW2 YIPF4 CLPTM1

1.24e-021347315EFO_0005192

Protein segments in the cluster

PeptideGeneStartEntry
FARWFSVPWKVIFVF

ARSH

186

Q5FYA8
FYRVANWLVERWHFI

PRMT9

141

Q6P2P2
KHWWQDLFRIVFRIF

ARFGEF1

1421

Q9Y6D6
FRFRFWQCGQWVEVV

CAPN13

126

Q6MZZ7
VWATVFLEFWKRRRA

ANO4

436

Q32M45
FIWINRDQRSFEWFV

NOX5

636

Q96PH1
GVWVTLFLEFWKRRQ

ANO6

386

Q4KMQ2
IVIRWFWAAVERFNN

HECW2

1476

Q9P2P5
SIRIQDGFIIFRWWK

KIAA1109

96

Q2LD37
WFVNPLKTFVFFIWR

FER1L4

1741

A9Z1Z3
FIWVTRTQRQFEWLA

DUOX2

1416

Q9NRD8
RTRRSWVWNQFFVIE

CDH24

41

Q86UP0
VRRFFWWARFIAINT

TMEM63C

401

Q9P1W3
WWARFIAINTFLFFL

TMEM63C

406

Q9P1W3
IQIQWFWRALRSFDQ

HUWE1

4276

Q7Z6Z7
YVWRSAVGFLFWVIV

PSENEN

56

Q9NZ42
IRVVHARVINFSWAW

OPN3

141

Q9H1Y3
ARVINFSWAWRAITY

OPN3

146

Q9H1Y3
VRRAWQRIISWVFFW

C7orf61

11

Q8IZ16
RTKRSWVWNQFFVLE

CDH20

56

Q9HBT6
GWIWLAVVFVFRLLV

GJB7

21

Q6PEY0
TFAILIFFWVLWVAV

SLC44A3

336

Q8N4M1
RVKRGWVWNQFFVLE

CDH12

51

P55289
VFFLFSRWLAESARW

SLC22A25

271

Q6T423
WRLFRNIFVAWFVTV

SLC20A2

616

Q08357
FFIGFAALVIWWQRV

COX4I2

111

Q96KJ9
QEQRATVRALWFWAF

SFI1

836

A8K8P3
IVRVVFFPFFFRWWL

PHTF2

116

Q8N3S3
VFFLLSRWLVESARW

SLC22A10

271

Q63ZE4
VLALTWTVWRFFLRD

PTDSS2

421

Q9BVG9
WTVWRFFLRDITLRY

PTDSS2

426

Q9BVG9
VFLWRTAAFWAFTVF

SHLD2

486

Q86V20
FRIFIIWAISSWFRR

CLPTM1

61

O96005
SLVVWSFREWIRKFN

TAS2R5

26

Q9NYW4
WTQLWFFRFVVNAAG

SLC35B2

31

Q8TB61
YGQFRVVSWIITIWI

YIPF4

131

Q9BSR8
RWNLFIFILTYTVAW

KCNJ3

81

P48549