Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	endopeptidase activity	RCE1 ERVK-6 HGFAC PRSS12 ERVK-7 LPA ADAMTS16 ERVK-8 ADAMTS18 HABP2 CAPN5 ERVK-25 MMP16	4.14e-07	430	105	13	GO:0004175
GeneOntologyMolecularFunction	peptidase activity	RCE1 ERVK-6 HGFAC PRSS12 ERVK-7 LPA ADAMTS16 ERVK-8 ADAMTS18 HABP2 CAPN5 ERVK-25 AGBL2 MMP16	8.35e-06	654	105	14	GO:0008233
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-7 ERVK-8	2.26e-05	11	105	3	GO:0004523
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-7 ERVK-8 ERVK-25	4.17e-05	37	105	4	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-7 ERVK-8 ERVK-25	4.64e-05	38	105	4	GO:0070001
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-7 ERVK-8	4.93e-05	14	105	3	GO:0003964
GeneOntologyMolecularFunction	anandamide 8,9 epoxidase activity	CYP2D7 CYP2D6	1.63e-04	4	105	2	GO:0062187
GeneOntologyMolecularFunction	anandamide 11,12 epoxidase activity	CYP2D7 CYP2D6	1.63e-04	4	105	2	GO:0062188
GeneOntologyMolecularFunction	steroid 21-monooxygenase activity	CYP2D7 CYP2D6	1.63e-04	4	105	2	GO:0004509
GeneOntologyMolecularFunction	progesterone 21-hydroxylase activity	CYP2D7 CYP2D6	1.63e-04	4	105	2	GO:0106309
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-7 ERVK-8	1.75e-04	21	105	3	GO:0035613
GeneOntologyMolecularFunction	anandamide 14,15 epoxidase activity	CYP2D7 CYP2D6	4.05e-04	6	105	2	GO:0062189
GeneOntologyMolecularFunction	anandamide epoxidase activity	CYP2D7 CYP2D6	4.05e-04	6	105	2	GO:0062186
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-8	9.64e-04	37	105	3	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-7 ERVK-8	1.04e-03	38	105	3	GO:0034061
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 NMNAT2 ERVK-7 PARP14 ERVK-8	1.25e-03	152	105	5	GO:0016779
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-8	1.82e-03	46	105	3	GO:0016893
GeneOntologyMolecularFunction	catecholamine binding	SLC6A3 ADRB2	2.06e-03	13	105	2	GO:1901338
GeneOntologyBiologicalProcess	nuclear export	ERVK-6 SMG1 MDM2 EIF6 MDN1 NUP155 LTV1 XPOT	4.78e-06	185	105	8	GO:0051168
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-7 ERVK-8	3.53e-05	13	105	3	GO:0015074
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection assembly	TMEM67 RAPGEF6 CFAP43 STIL DNAI3 DAW1 NEURL1 ADAMTS16 WRAP73 KCNQ1 FAM149B1 EMP1 OCLN	3.58e-05	670	105	13	GO:0120031
GeneOntologyBiologicalProcess	cell projection assembly	TMEM67 RAPGEF6 CFAP43 STIL DNAI3 DAW1 NEURL1 ADAMTS16 WRAP73 KCNQ1 FAM149B1 EMP1 OCLN	4.50e-05	685	105	13	GO:0030031
GeneOntologyBiologicalProcess	ribosomal subunit export from nucleus	EIF6 MDN1 LTV1	6.84e-05	16	105	3	GO:0000054
GeneOntologyBiologicalProcess	ribosome localization	EIF6 MDN1 LTV1	6.84e-05	16	105	3	GO:0033750
GeneOntologyBiologicalProcess	serotonin biosynthetic process from tryptophan	CYP2D7 CYP2D6	7.68e-05	3	105	2	GO:0006587
GeneOntologyBiologicalProcess	dopamine biosynthetic process	CYP2D7 CYP2D6 SLC6A3	8.28e-05	17	105	3	GO:0042416
GeneOntologyBiologicalProcess	aromatic amino acid metabolic process	CYP2D7 CYP2D6 SLC45A2 CARNMT1	8.78e-05	46	105	4	GO:0009072
GeneOntologyBiologicalProcess	cilium assembly	TMEM67 CFAP43 STIL DNAI3 DAW1 NEURL1 ADAMTS16 WRAP73 KCNQ1 FAM149B1	9.00e-05	444	105	10	GO:0060271
GeneOntologyBiologicalProcess	cilium organization	TMEM67 CFAP43 STIL DNAI3 DAW1 NEURL1 ADAMTS16 WRAP73 KCNQ1 FAM149B1	1.59e-04	476	105	10	GO:0044782
GeneOntologyBiologicalProcess	phenol-containing compound biosynthetic process	CYP2D7 CYP2D6 SLC6A3 SLC45A2	2.04e-04	57	105	4	GO:0046189
GeneOntologyCellularComponent	extracellular matrix	LAMB4 ADAMTSL1 FN1 EYS FGFBP3 LPA ADAMTS16 ADAMTS18 PZP MMP16 MUC2 TNXB	1.35e-04	656	107	12	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	LAMB4 ADAMTSL1 FN1 EYS FGFBP3 LPA ADAMTS16 ADAMTS18 PZP MMP16 MUC2 TNXB	1.39e-04	658	107	12	GO:0030312
Domain	Kringle-like	HGFAC FN1 PRSS12 LPA HABP2	7.88e-07	32	102	5	IPR013806
Domain	Kringle	HGFAC PRSS12 LPA HABP2	1.89e-06	17	102	4	IPR000001
Domain	Kringle_CS	HGFAC PRSS12 LPA HABP2	1.89e-06	17	102	4	IPR018056
Domain	KRINGLE_2	HGFAC PRSS12 LPA HABP2	1.89e-06	17	102	4	PS50070
Domain	Kringle	HGFAC PRSS12 LPA HABP2	1.89e-06	17	102	4	PF00051
Domain	KRINGLE_1	HGFAC PRSS12 LPA HABP2	1.89e-06	17	102	4	PS00021
Domain	KR	HGFAC PRSS12 LPA HABP2	1.89e-06	17	102	4	SM00130
Domain	PLAC	ADAMTSL1 ADAMTS16 ADAMTS18	5.51e-05	14	102	3	PF08686
Domain	-	CFAP43 SEC31B DNAI3 LYST SEMA4C FZR1 DAW1 WRAP73 WDFY3	8.74e-05	333	102	9	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	CFAP43 SEC31B DNAI3 LYST SEMA4C FZR1 DAW1 WRAP73 WDFY3	9.15e-05	335	102	9	IPR015943
Domain	WD40	CFAP43 SEC31B DNAI3 LYST FZR1 DAW1 WRAP73 WDFY3	1.11e-04	268	102	8	SM00320
Domain	WD40_repeat	CFAP43 SEC31B DNAI3 LYST FZR1 DAW1 WRAP73 WDFY3	1.23e-04	272	102	8	IPR001680
Domain	WD_REPEATS_1	CFAP43 SEC31B DNAI3 LYST FZR1 DAW1 WRAP73 WDFY3	1.43e-04	278	102	8	PS00678
Domain	PLAC	ADAMTSL1 ADAMTS16 ADAMTS18	1.44e-04	19	102	3	PS50900
Domain	PLAC	ADAMTSL1 ADAMTS16 ADAMTS18	1.44e-04	19	102	3	IPR010909
Domain	WD_REPEATS_2	CFAP43 SEC31B DNAI3 LYST FZR1 DAW1 WRAP73 WDFY3	1.46e-04	279	102	8	PS50082
Domain	WD_REPEATS_REGION	CFAP43 SEC31B DNAI3 LYST FZR1 DAW1 WRAP73 WDFY3	1.46e-04	279	102	8	PS50294
Domain	FN1_2	HGFAC FN1	1.76e-04	4	102	2	PS51091
Domain	fn1	HGFAC FN1	1.76e-04	4	102	2	PF00039
Domain	Fibronectin_type1	HGFAC FN1	1.76e-04	4	102	2	IPR000083
Domain	FN1	HGFAC FN1	1.76e-04	4	102	2	SM00058
Domain	FN1_1	HGFAC FN1	1.76e-04	4	102	2	PS01253
Domain	Peptidase_M12B_ADAM-TS	ADAMTSL1 ADAMTS16 ADAMTS18	2.94e-04	24	102	3	IPR013273
Domain	TSP_1	ADAMTSL1 THSD7A ADAMTS16 ADAMTS18	3.90e-04	63	102	4	PF00090
Domain	PH_BEACH	LYST WDFY3	4.37e-04	6	102	2	PF14844
Domain	TSP1	ADAMTSL1 THSD7A ADAMTS16 ADAMTS18	4.40e-04	65	102	4	SM00209
Domain	TSP1_rpt	ADAMTSL1 THSD7A ADAMTS16 ADAMTS18	4.40e-04	65	102	4	IPR000884
Domain	TSP1	ADAMTSL1 THSD7A ADAMTS16 ADAMTS18	4.40e-04	65	102	4	PS50092
Domain	WD40	SEC31B DNAI3 LYST FZR1 DAW1 WRAP73 WDFY3	5.48e-04	259	102	7	PF00400
Domain	EGF-like_CS	HGFAC LAMB4 FN1 EYS HABP2 TNXB SORL1	5.74e-04	261	102	7	IPR013032
Domain	PH-BEACH_dom	LYST WDFY3	8.09e-04	8	102	2	IPR023362
Domain	-	LYST WDFY3	8.09e-04	8	102	2	2.30.29.40
Domain	PH_BEACH	LYST WDFY3	8.09e-04	8	102	2	PS51783
Domain	BEACH_dom	LYST WDFY3	1.04e-03	9	102	2	IPR000409
Domain	BEACH	LYST WDFY3	1.04e-03	9	102	2	PS50197
Domain	Beach	LYST WDFY3	1.04e-03	9	102	2	PF02138
Domain	-	LYST WDFY3	1.04e-03	9	102	2	1.10.1540.10
Domain	Beach	LYST WDFY3	1.04e-03	9	102	2	SM01026
Domain	Sialidases	NEU3 SORL1	1.04e-03	9	102	2	IPR011040
Domain	WD40_repeat_dom	CFAP43 SEC31B DNAI3 LYST FZR1 DAW1 WDFY3	1.22e-03	297	102	7	IPR017986
Domain	CYSTEINE_SWITCH	ADAMTS16 ADAMTS18 MMP16	1.45e-03	41	102	3	PS00546
Domain	Pept_M10_metallopeptidase	ADAMTS16 ADAMTS18 MMP16	1.67e-03	43	102	3	IPR001818
Domain	6-blade_b-propeller_TolB-like	DAW1 WRAP73 SORL1	2.02e-03	46	102	3	IPR011042
Domain	WD40_repeat_CS	SEC31B LYST FZR1 DAW1 WDFY3	2.06e-03	164	102	5	IPR019775
Domain	-	HGFAC FN1	2.22e-03	13	102	2	2.10.10.10
Domain	TRYPSIN_HIS	HGFAC PRSS12 LPA HABP2	2.45e-03	103	102	4	IPR018114
Domain	FN_type2_col-bd	HGFAC FN1	2.57e-03	14	102	2	IPR000562
Domain	FN2_2	HGFAC FN1	2.57e-03	14	102	2	PS51092
Domain	EamA_dom	SLC35G2 SLC35G4	2.57e-03	14	102	2	IPR000620
Domain	EamA	SLC35G2 SLC35G4	2.57e-03	14	102	2	PF00892
Domain	fn2	HGFAC FN1	2.57e-03	14	102	2	PF00040
Domain	FN2_1	HGFAC FN1	2.57e-03	14	102	2	PS00023
Domain	FN2	HGFAC FN1	2.57e-03	14	102	2	SM00059
Domain	ARM-type_fold	SMG1 LYST TERB1 PDS5A WDFY3 TARBP1 XPOT	2.58e-03	339	102	7	IPR016024
Domain	TRYPSIN_SER	HGFAC PRSS12 LPA HABP2	2.72e-03	106	102	4	PS00135
Domain	EGF_1	HGFAC LAMB4 FN1 EYS HABP2 TNXB	2.76e-03	255	102	6	PS00022
Domain	TRYPSIN_HIS	HGFAC PRSS12 LPA HABP2	2.81e-03	107	102	4	PS00134
Domain	EGF_2	HGFAC LAMB4 EYS HABP2 TNXB SORL1	3.34e-03	265	102	6	PS01186
Domain	Peptidase_S1A	HGFAC PRSS12 LPA HABP2	3.42e-03	113	102	4	IPR001314
Domain	TRYPSIN_DOM	HGFAC PRSS12 LPA HABP2	3.65e-03	115	102	4	PS50240
Domain	ARM-like	SMG1 TERB1 PDS5A WDFY3 TARBP1 XPOT	3.65e-03	270	102	6	IPR011989
Domain	Tryp_SPc	HGFAC PRSS12 LPA HABP2	3.88e-03	117	102	4	SM00020
Domain	Trypsin	HGFAC PRSS12 LPA HABP2	4.37e-03	121	102	4	PF00089
Domain	Trypsin_dom	HGFAC PRSS12 LPA HABP2	4.37e-03	121	102	4	IPR001254
Domain	Peptidase_S1_PA	HGFAC PRSS12 LPA HABP2	4.63e-03	123	102	4	IPR009003
Domain	EGF	HGFAC EYS HABP2 TNXB	5.04e-03	126	102	4	PF00008
Domain	RasGEFN	RAPGEF6 KNDC1	5.26e-03	20	102	2	SM00229
Domain	Apc4_WD40_dom	FZR1 WRAP73	5.26e-03	20	102	2	IPR024977
Domain	ANAPC4_WD40	FZR1 WRAP73	5.26e-03	20	102	2	PF12894
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTSL1 THSD7A ADAMTS16 ADAMTS18	3.80e-05	39	69	4	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTSL1 THSD7A ADAMTS16 ADAMTS18	3.80e-05	39	69	4	MM15165
Pubmed	The DNA sequence and analysis of human chromosome 6.	ERVK-6 PDCD2 HTR1B CD164 LINC02901 NRN1 EYS MDN1 CRYBG1 KIF13A DSE HDAC2	5.64e-07	622	108	12	14574404
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	RCE1 LAMB4 FN1 RNF213 LINC02901 PARP14 ITGAE MDN1 PDS5A PWWP3B CFAP418 DSE	3.22e-06	736	108	12	29676528
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	SMG1 CTC1 RNF213 MDM2 LYST CRYBG1 ERVK-25 MUC2 TNXB ZNF639	9.01e-06	552	108	10	10737800
Pubmed	Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.	RNF213 OCLN	9.55e-06	2	108	2	18318008
Pubmed	A Selective Extracellular Matrix Proteomics Approach Identifies Fibronectin Proteolysis by A Disintegrin-like and Metalloprotease Domain with Thrombospondin Type 1 Motifs (ADAMTS16) and Its Impact on Spheroid Morphogenesis.	FN1 ADAMTS16	9.55e-06	2	108	2	29669734
Pubmed	Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.	CYP2D7 CYP2D6	9.55e-06	2	108	2	25808902
Pubmed	Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?	CYP2D7 CYP2D6	9.55e-06	2	108	2	11207030
Pubmed	Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.	CYP2D7 CYP2D6	9.55e-06	2	108	2	3123997
Pubmed	Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it.	FN1 LPA	9.55e-06	2	108	2	2531657
Pubmed	Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.	CYP2D7 CYP2D6	9.55e-06	2	108	2	11032406
Pubmed	Elements in the C terminus of apolipoprotein [a] responsible for the binding to the tenth type III module of human fibronectin.	FN1 LPA	9.55e-06	2	108	2	16150826
Pubmed	The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.	CYP2D7 CYP2D6	9.55e-06	2	108	2	19594327
Pubmed	Coding-noncoding gene expression in intrahepatic cholangiocarcinoma.	CYP2D7 CYP2D6	9.55e-06	2	108	2	26297049
Pubmed	Evaluation of ADAMTS12, ADAMTS16, ADAMTS18 and IL-33 serum levels in pre-eclampsia.	ADAMTS16 ADAMTS18	9.55e-06	2	108	2	26382559
Pubmed	A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.	CYP2D7 CYP2D6	9.55e-06	2	108	2	15051713
Pubmed	Novel interaction of apolipoprotein(a) with beta-2 glycoprotein I mediated by the kringle IV domain.	FN1 LPA	2.86e-05	3	108	2	9269765
Pubmed	Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens.	HTR1B SLC6A3	2.86e-05	3	108	2	35545050
Pubmed	Carvedilol pharmacokinetics and pharmacodynamics in relation to CYP2D6 and ADRB pharmacogenetics.	CYP2D6 ADRB2	2.86e-05	3	108	2	21599570
Pubmed	Neuritin affects the activity of neuralized-like 1 by promoting degradation and weakening its affinity for substrate.	NRN1 NEURL1	2.86e-05	3	108	2	37249336
Pubmed	Roles of HDAC2, eIF5, and eIF6 in Lung Cancer Tumorigenesis.	EIF6 HDAC2	2.86e-05	3	108	2	34403101
Pubmed	Expression of tenascin in developing and adult mouse lymphoid organs.	FN1 TNXB	2.86e-05	3	108	2	7687262
Pubmed	Lack of association between schizophrenia and polymorphisms in dopamine metabolism and transport genes.	CYP2D6 SLC6A3	2.86e-05	3	108	2	20041956
Pubmed	The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.	CYP2D7 CYP2D6	2.86e-05	3	108	2	2574001
Pubmed	Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction.	HTR1B SLC6A3	2.86e-05	3	108	2	34516792
Pubmed	Fibronectin 1 derived from tumor-associated macrophages and fibroblasts promotes metastasis through the JUN pathway in hepatocellular carcinoma.	FN1 KIF13A	2.86e-05	3	108	2	36461607
Pubmed	Identification of the primary gene defect at the cytochrome P450 CYP2D locus.	CYP2D7 CYP2D6	2.86e-05	3	108	2	1978251
Pubmed	ADAMTS18 regulates early branching morphogenesis of lacrimal gland and has a significant association with the risk of dry eye in mice.	FN1 ADAMTS18	5.71e-05	4	108	2	35240198
Pubmed	Intraocular pressure response to topical beta-blockers associated with an ADRB2 single-nucleotide polymorphism.	CYP2D6 ADRB2	5.71e-05	4	108	2	18625943
Pubmed	Selective inhibition of histone deacetylase 2 induces p53-dependent survivin downregulation through MDM2 proteasomal degradation.	MDM2 HDAC2	5.71e-05	4	108	2	25605253
Pubmed	Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.	MDM2 ADRB2	5.71e-05	4	108	2	11588219
Pubmed	Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18.	ADAMTS16 ADAMTS18	5.71e-05	4	108	2	16507336
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7	5.71e-05	4	108	2	10469592
Pubmed	Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.	HTR1B SLC6A3	5.71e-05	4	108	2	29949769
Pubmed	HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression.	MDM2 HDAC2	5.71e-05	4	108	2	30818224
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTSL1 THSD7A ADAMTS16 ADAMTS18	9.02e-05	75	108	4	20637190
Pubmed	Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorder.	HTR1B SLC6A3	9.50e-05	5	108	2	17501935
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-7	9.50e-05	5	108	2	12629516
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	9.50e-05	5	108	2	11401426
Pubmed	Investigation of parent-of-origin effects in ADHD candidate genes.	HTR1B SLC6A3	9.50e-05	5	108	2	17427194
Pubmed	Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development.	FN1 MDM2	9.50e-05	5	108	2	22821713
Pubmed	No preferential transmission of paternal alleles at risk genes in attention-deficit hyperactivity disorder.	HTR1B SLC6A3	9.50e-05	5	108	2	17325714
Pubmed	A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.	MDM2 ADRB2	9.50e-05	5	108	2	21857681
Pubmed	PARP-14 functions as a transcriptional switch for Stat6-dependent gene activation.	PARP14 HDAC2	9.50e-05	5	108	2	21081493
Pubmed	A unified taxonomy for ciliary dyneins.	DNAI3 DAW1	1.42e-04	6	108	2	21953912
Pubmed	Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.	MDM2 ADRB2	1.42e-04	6	108	2	18544533
Pubmed	Polymorphism of metabolic genes and susceptibility to occupational chronic manganism.	CYP2D7 CYP2D6	1.42e-04	6	108	2	12171760
Pubmed	Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestine.	CLDN15 OCLN	1.42e-04	6	108	2	16651389
Pubmed	Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon.	CYP2D6 NEU3 MUC2	1.48e-04	33	108	3	16618389
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TCAF1 THSD7A RNF213 SEMA4C ZBTB39 SSH1 ADAMTS16 PDS5A	1.57e-04	493	108	8	15368895
Pubmed	The human plasma proteome: a nonredundant list developed by combination of four separate sources.	HGFAC FN1 LPA HABP2 PZP	1.70e-04	165	108	5	14718574
Pubmed	No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs.	HTR1B SLC6A3	1.99e-04	7	108	2	28176268
Pubmed	Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.	ADAMTS16 ADAMTS18	1.99e-04	7	108	2	11867212
Pubmed	Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.	CYP2D7 CYP2D6	1.99e-04	7	108	2	30944282
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	FN1 ADAMTS16 ADAMTS18	2.10e-04	37	108	3	34323105
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-7 ERVK-8 ERVK-25	2.16e-04	94	108	4	21542922
Pubmed	Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population.	HTR1B SLC6A3	2.64e-04	8	108	2	19673036
Pubmed	Mice develop normally without tenascin.	FN1 TNXB	2.64e-04	8	108	2	1383086
Pubmed	Polymorphism in environment responsive genes and association with Parkinson disease.	CYP2D6 SLC6A3	2.64e-04	8	108	2	18327668
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	RNF213 MDN1 TARBP1 XPOT	3.18e-04	104	108	4	31240132
Pubmed	Genetic control of retinal ganglion cell projections.	LYST SLC45A2	3.39e-04	9	108	2	102659
Pubmed	Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering.	FLII OCLN	3.39e-04	9	108	2	24375017
Pubmed	The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.	SLC6A3 ADRB2	3.39e-04	9	108	2	16894395
Pubmed	SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families.	HTR1B SLC6A3	3.39e-04	9	108	2	18821566
Pubmed	Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.	CYP2D6 SLC6A3 ADRB2 KCNQ1	3.68e-04	108	108	4	19956635
Pubmed	Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects.	CYP2D6 KCNQ1	4.23e-04	10	108	2	21063774
Pubmed	Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.	HTR1B CYP2D6 SLC6A3	5.76e-04	52	108	3	18583979
Pubmed	EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins.	CLDN15 OCLN	6.18e-04	12	108	2	22819673
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8	6.18e-04	12	108	2	14557543
Pubmed	HDAC1 and HDAC2 orchestrate Wnt signaling to regulate neural progenitor transition during brain development.	OCLN HDAC2	7.29e-04	13	108	2	39224519
Pubmed	Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.	EYS CSMD1	7.29e-04	13	108	2	22993228
Pubmed	Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.	SLC6A3 ADRB2	7.29e-04	13	108	2	18937294
Pubmed	Extra-embryonic-specific imprinted expression is restricted to defined lineages in the post-implantation embryo.	LPA KCNQ1	7.29e-04	13	108	2	21354127
Pubmed	Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.	HGFAC FN1 PZP	8.34e-04	59	108	3	17330941
Pubmed	The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis.	HTR1B SLC6A3	8.48e-04	14	108	2	18937842
Pubmed	Deletion of astroglial connexins weakens the blood-brain barrier.	FN1 OCLN	8.48e-04	14	108	2	22472609
Pubmed	A case-control study of Parkinson's disease and tobacco use: gene-tobacco interactions.	CYP2D6 SLC6A3	8.48e-04	14	108	2	20461808
Pubmed	Membrane-type MMPs are indispensable for placental labyrinth formation and development.	FN1 MMP16	8.48e-04	14	108	2	20858856
Pubmed	The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.	FN1 OCLN	8.48e-04	14	108	2	22144466
Pubmed	The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice.	OCLN MUC2	8.48e-04	14	108	2	29361518
Pubmed	Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease.	ADAMTS16 ADAMTS18	8.48e-04	14	108	2	31242448
Pubmed	Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease.	MDM2 ADRB2 LPA	8.76e-04	60	108	3	12082592
Pubmed	Characterization of the piRNA complex from rat testes.	SEC31B ARFGAP2 CGRRF1 WDFY3	9.75e-04	140	108	4	16778019
Pubmed	Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.	CSMD1 MUC2	9.77e-04	15	108	2	23583980
Pubmed	Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia.	FN1 PRSS12	9.77e-04	15	108	2	23401504
Pubmed	Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.	NEURL1 KCNQ1	9.77e-04	15	108	2	20526338
Pubmed	The species-specific differences in the cAMP regulation of the tissue-type plasminogen activator gene between rat, mouse and human is caused by a one-nucleotide substitution in the cAMP-responsive element of the promoters.	ADAMTS16 ADAMTS18	9.77e-04	15	108	2	7543410
Pubmed	Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation.	FN1 ADAMTS16	9.77e-04	15	108	2	38018454
Pubmed	Gene-environment interactions in parkinsonism and Parkinson's disease: the Geoparkinson study.	CYP2D6 SLC6A3	9.77e-04	15	108	2	17449559
Pubmed	Many sequence variants affecting diversity of adult human height.	CD164 EIF6 KIF13A TNXB	1.05e-03	143	108	4	18391951
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	FN1 MDM2 FZR1 IL21 OCLN HDAC2	1.09e-03	371	108	6	25241761
Pubmed	Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.	NEURL1 CSMD1 MMP16	1.11e-03	65	108	3	23453885
Pubmed	The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors.	FN1 HABP2	1.11e-03	16	108	2	33454424
Pubmed	Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice.	FN1 OCLN	1.11e-03	16	108	2	11564885
Pubmed	ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.	ADAMTS16 ADAMTS18	1.11e-03	16	108	2	30579834
Pubmed	Physical and transcriptional map of the mouse Chromosome 10 proximal region syntenic to human 6q16-q21.	CD164 CRYBG1	1.11e-03	16	108	2	11707774
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	FLII RNF213 PARP14 EIF6 NUP155	1.13e-03	250	108	5	33536335
Pubmed	Screening E3 substrates using a live phage display library.	MDM2 PDS5A	1.26e-03	17	108	2	24124579
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	HGFAC FN1 HLA-DMB PZP TNXB	1.27e-03	257	108	5	16335952
Pubmed	HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway.	HLA-DMB LYST	1.42e-03	18	108	2	19620308
Pubmed	Candidate gene studies of ADHD: a meta-analytic review.	HTR1B SLC6A3	1.42e-03	18	108	2	19506906
GeneFamily	WD repeat domain containing	CFAP43 SEC31B DNAI3 LYST FZR1 DAW1 WRAP73 WDFY3	9.39e-06	262	72	8	362
GeneFamily	WD repeat domain containing\|BEACH domain containing	LYST WDFY3	5.53e-04	9	72	2	1230
Coexpression	NABA_MATRISOME	HGFAC LAMB4 ADAMTSL1 FN1 PRSS12 SEMA4C EYS FGFBP3 LPA ADAMTS16 ADAMTS18 HABP2 PZP MMP16 MUC2 TNXB	2.83e-06	1026	104	16	M5889
Coexpression	NABA_ECM_REGULATORS	ADAMTSL1 PRSS12 LPA ADAMTS16 ADAMTS18 HABP2 PZP MMP16	5.00e-06	238	104	8	M3468
Coexpression	NABA_ECM_REGULATORS	ADAMTSL1 PRSS12 LPA ADAMTS16 ADAMTS18 HABP2 PZP MMP16	5.65e-06	242	104	8	MM17062
Coexpression	NABA_MATRISOME_ASSOCIATED	HGFAC ADAMTSL1 PRSS12 SEMA4C FGFBP3 LPA ADAMTS16 ADAMTS18 HABP2 PZP MMP16 MUC2	3.68e-05	738	104	12	MM17058
Coexpression	NABA_MATRISOME_ASSOCIATED	HGFAC ADAMTSL1 PRSS12 SEMA4C FGFBP3 LPA ADAMTS16 ADAMTS18 HABP2 PZP MMP16 MUC2	4.36e-05	751	104	12	M5885
Coexpression	NABA_MATRISOME	HGFAC ADAMTSL1 FN1 PRSS12 SEMA4C FGFBP3 LPA ADAMTS16 ADAMTS18 HABP2 PZP MMP16 MUC2 TNXB	4.49e-05	1008	104	14	MM17056
Coexpression	GSE3565_DUSP1_VS_WT_SPLENOCYTES_POST_LPS_INJECTION_UP	GPR15 RAPGEF6 LYST MDN1 NUP155 LTV1	5.18e-05	165	104	6	M6332
Coexpression	GSE37532_TREG_VS_TCONV_CD4_TCELL_FROM_VISCERAL_ADIPOSE_TISSUE_DN	RNF213 STIL MDM2 CGRRF1 PWWP3B HDAC2	5.92e-05	169	104	6	M8937
Coexpression	PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_4	BRIP1 FN1 MSMB PWWP3B EMP1	7.20e-05	108	104	5	M2410
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D175\|Adult / Lineage, Cell type, age group and donor	THSD7A SLC35G2 SLC45A2 EMP1 CSMD1 MMP16	3.52e-06	175	104	6	0a65ddfa8c2e8efb5b5338cf07661cb78157a23c
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NMNAT2 GPR21 THSD7A CLDN15 CAPN5 OCLN	4.01e-06	179	104	6	a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TMEM67 CFAP43 DNAI3 KNDC1 AGBL2 PZP	4.84e-06	185	104	6	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD7A FN1 SLC35G2 SSH1 CSMD1 MMP16	5.47e-06	189	104	6	b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 THSD7A NEURL1 ADAMTS16 KCNQ1 CRYBG1	5.64e-06	190	104	6	b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 THSD7A CTC1 RNF213 SEC31B OCLN	6.17e-06	193	104	6	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	HTR1B PRSS12 ADAMTS18 MUC2 SORL1	6.32e-06	111	104	5	1847dde68d349114286bc3317be6339666df4aa2
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTSL1 THSD7A NRN1 ADAMTS18 EMP1 MMP16	6.74e-06	196	104	6	5609b2d93172a488b35d854298a3a4e504e17e28
ToppCell	Biopsy_Control_(H.)-Epithelial-Ciliated\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	TMEM67 PRSS12 CFAP43 DNAI3 DAW1 AGBL2	7.56e-06	200	104	6	9ae434c78e08adf95da49c85616e3ca72d1227bf
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CFAP43 DNAI3 DAW1 KNDC1 AGBL2 PZP	7.56e-06	200	104	6	31d75c26055177d656df1fbb10b764cebd61e122
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CFAP43 DNAI3 DAW1 KNDC1 AGBL2 PZP	7.56e-06	200	104	6	e1dce91c6c531bb212002a14705e496d77ad3490
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	FN1 PRSS12 DNAI3 LPA PZP TNXB	7.56e-06	200	104	6	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	Sepsis-ICU-SEP-Myeloid-cDC2\|ICU-SEP / Disease, condition lineage and cell class	HLA-DMB CGRRF1 KNDC1 KCNQ1 CFAP418 EMP1	7.56e-06	200	104	6	09d5c3a3d2b42b15c769dc2bc14b6c0d5cc38f91
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	BRIP1 SEC31B DAW1 SLC45A2 EMP1	1.58e-05	134	104	5	d29ac8152dc581c0da2430d06cd259ac0eded808
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	BRIP1 SEC31B DAW1 SLC45A2 EMP1	1.58e-05	134	104	5	459c39df15d3cf9144ce7827e8d14830d31353bb
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Apod_(Apod)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	BRIP1 SEC31B DAW1 SLC45A2 EMP1	1.58e-05	134	104	5	d065449ca3679e4818b74fb7302cc7f1ce62f691
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Apod_(Apod)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	BRIP1 SEC31B DAW1 SLC45A2 EMP1	1.58e-05	134	104	5	0be389f416818a22e80098dd809fdf45b14171e8
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Tox_(Neuron.Slc17a7.Syt6-Tox)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	IL21 SLC45A2 PZP MUC2	1.96e-05	68	104	4	b8d472ff47312a8cc8ba60809947c82f4054d8de
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Tox_(Neuron.Slc17a7.Syt6-Tox)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	IL21 SLC45A2 PZP MUC2	1.96e-05	68	104	4	94acd088e39a17cd573aa3ad533b6634e3b7018d
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Syt6\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	IL21 SLC45A2 PZP MUC2	1.96e-05	68	104	4	89929e9e3a119f6eafef37a401e8fe2bd972452b
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TCAF1 XKR9 LINC02901 NUP155 FAM149B1	2.99e-05	153	104	5	8bc09b8b1a32a8d7ac8201c626d2b306e7cc2972
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	SMG1 RAPGEF6 CTC1 RNF213 CRYBG1	3.28e-05	156	104	5	1545169694f686d28648a68b552c2ae606599d66
ToppCell	Ciliated_cells-B-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	CFAP43 DNAI3 DAW1 AGBL2 PZP	4.16e-05	164	104	5	0e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM67 CFAP43 SLC45A2 AGBL2 PZP	4.80e-05	169	104	5	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7A KCNQ1 PWWP3B MMP16 MUC2	4.94e-05	170	104	5	af8b56555cbd5a1016ab9ec2ce88225c58c89648
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7A KCNQ1 PWWP3B MMP16 MUC2	5.22e-05	172	104	5	9a1743abcd5fbd38253ea84d88ad716cfb71de36
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM67 PRSS12 CFAP43 DNAI3 KNDC1	6.30e-05	179	104	5	5e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NMNAT2 NRN1 EYS MMP16 TNXB	6.47e-05	180	104	5	25f8e82bbc1853cb7d072484e99369c72779dd1e
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM67 CFAP43 DNAI3 KNDC1 PZP	6.47e-05	180	104	5	92fb01b91261b3103454924cde56add337b41844
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NMNAT2 GPR21 THSD7A CLDN15 OCLN	6.64e-05	181	104	5	136b0c60680068838d184d32aa99d7bea8718dbc
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THSD7A NRN1 EYS EMP1 MMP16	6.64e-05	181	104	5	0ba91575fe8851788cebc4cf5a6d76680bf586c5
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 NRN1 LYST EMP1 MMP16	6.82e-05	182	104	5	d0e3663f7d39f22a3ebd7fde56ab3504773598f4
ToppCell	Ciliated_cells-B-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	TMEM67 PRSS12 CFAP43 DNAI3 DAW1	6.82e-05	182	104	5	e93968f800bfeb258e4e834fc8bf92d1cb72cd73
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NMNAT2 GPR21 THSD7A OCLN AGBL2	7.18e-05	184	104	5	f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NMNAT2 GPR21 THSD7A OCLN AGBL2	7.18e-05	184	104	5	8bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCell	normal_Pleural_Fluid-Myeloid_cells-Alveolar_Mac\|normal_Pleural_Fluid / Location, Cell class and cell subclass	FN1 NRN1 CGRRF1 EMP1 KIF13A	7.56e-05	186	104	5	3314def702fe6a5056d0dadbb3a587c5d1a16412
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ELAPOR2 NMNAT2 NRN1 MMP16 TNXB	7.75e-05	187	104	5	65d406122dffe18279f14a1ed35ba091730b97be
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ELAPOR2 NMNAT2 NRN1 MMP16 TNXB	7.75e-05	187	104	5	4c15c0ed41a55271fc793cb76fee97fa64190369
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ELAPOR2 NMNAT2 NRN1 MMP16 TNXB	7.75e-05	187	104	5	5274f2b302bbf7fed30c480af4f35058d2cf61e0
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 CLDN15 ADRB2 EMP1 TNXB	7.95e-05	188	104	5	a37edd8f9e4a4e336b5acbb0407d3d275975cee8
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP43 DNAI3 DAW1 KNDC1 AGBL2	8.15e-05	189	104	5	28c750ac56e3861fe7280e32839a4d8ce8bd8692
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP43 DNAI3 DAW1 KNDC1 AGBL2	8.15e-05	189	104	5	efee01edd171bf569267b672fab05c421de6c92d
ToppCell	facs-Lung-nan-3m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP43 DNAI3 DAW1 KNDC1 AGBL2	8.35e-05	190	104	5	e243b5fbb17b9ec3cc90bbe970c1d30b0fd1c2e1
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC35G2 NRN1 ADAMTS18 LTV1 EMP1	8.35e-05	190	104	5	a318d80dd5cc33d43048883b0e7844b5aa280aab
ToppCell	facs-Lung-nan-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP43 DNAI3 DAW1 KNDC1 AGBL2	8.35e-05	190	104	5	fe844559b95832845d2e8d3ab4b57e3d558bc372
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFAP43 DNAI3 DAW1 KNDC1 AGBL2	8.56e-05	191	104	5	649fcb62ad15de2f83e61591e43923a717664ae7
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFAP43 DNAI3 DAW1 KNDC1 AGBL2	8.56e-05	191	104	5	9621e22e14ea069f22713947c9faa2d882abe5fe
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SMG1 RAPGEF6 RNF213 CRYBG1 SORL1	8.77e-05	192	104	5	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	RV-10._Endothelium_II\|RV / Chamber and Cluster_Paper	ADAMTSL1 THSD7A FN1 PARP14 PWWP3B	8.99e-05	193	104	5	01c2df9206f1527c578e808978e58196c35e72f5
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 FN1 CD163L1 ADAMTS18 TNXB	8.99e-05	193	104	5	1f978e102a029a6beb10913052cd0a20c7253e8e
ToppCell	NS-critical-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TMEM67 CFAP43 DNAI3 DAW1 AGBL2	9.21e-05	194	104	5	1ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell	3'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 SLC35G2 NRN1 ADRB2 EMP1	9.44e-05	195	104	5	d46955155e5b22d00939eaf5edfb8ac217d06e46
ToppCell	moderate-Epithelial-Ciliated\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TMEM67 CFAP43 DNAI3 DAW1 AGBL2	9.44e-05	195	104	5	e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD7A FN1 CLDN15 NRN1 TNXB	9.67e-05	196	104	5	a20a56d8997d6db2a10046c8801c619a379de83c
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 CTC1 RNF213 SEMA4C PZP	9.90e-05	197	104	5	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	Parenchyma_Control_(B.)-Endothelial-TX-Endothelial-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	THSD7A NRN1 ADAMTS18 EMP1 MMP16	9.90e-05	197	104	5	f969685dee212f33a6f09e54c0cd1fd24ffef546
ToppCell	distal-Endothelial-Bronchial_Vessel_1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	THSD7A NRN1 ADAMTS18 EMP1 MMP16	9.90e-05	197	104	5	f45a93b5ad80a16b760acbaa6467648ffc05a0d3
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	THSD7A NRN1 ADAMTS18 EMP1 MMP16	9.90e-05	197	104	5	1a137af40697137bb9d2b5caf2b1ffda55f04461
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	THSD7A NRN1 ADAMTS18 EMP1 MMP16	9.90e-05	197	104	5	96d63a8d00583e2aa0a38412e2ae27e23f399493
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THSD7A FN1 SLC35G2 NRN1 EMP1	1.01e-04	198	104	5	8a55589b9244283e4b0b423a4a6d6202e8e0fec9
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THSD7A FN1 SLC35G2 NRN1 EMP1	1.01e-04	198	104	5	d1f54ed3ef5e05ebda7da999e172d168dc6802cd
ToppCell	5'-Adult-Distal_Rectal-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THSD7A FN1 SLC35G2 NRN1 EMP1	1.01e-04	198	104	5	8d6b0b9da7c1e64155cbcbb04ad38d129a29030c
ToppCell	Healthy_Control-Myeloid-Macrophages-FCN1+SPP1+\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	MDM2 LYST EMP1 DSE XPOT	1.01e-04	198	104	5	aa90326b82e21de37af5642df6a70a8b21af7f04
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THSD7A FN1 SLC35G2 NRN1 EMP1	1.01e-04	198	104	5	58508a8df2714d769f137794c29441a7bd38b350
ToppCell	distal-3-Endothelial-Bronchial_Vessel_1\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	THSD7A SLC35G2 NRN1 ADAMTS18 EMP1	1.01e-04	198	104	5	00fdee373eaa43c9ce897f2ba2ecbe94cedea93a
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MSMB CD163L1 NEURL1 EMP1 SORL1	1.04e-04	199	104	5	01d101b0fd5326947a9e5dddae6c2f93ab6e0a4d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD7A FN1 CLDN15 NRN1 TNXB	1.04e-04	199	104	5	f35e9c05d0a0339ff691b38564da7aad8e9218aa
ToppCell	3'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THSD7A FN1 SLC35G2 NRN1 EMP1	1.04e-04	199	104	5	0075bcc7d2a5031e76a24cb176e16ac998d846fd
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FN1 PRSS12 DNAI3 PZP TNXB	1.04e-04	199	104	5	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MSMB CD163L1 NEURL1 EMP1 SORL1	1.04e-04	199	104	5	6d439c0c5e6b72fcb8d4dc72e7445eb6a01fe095
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM67 PRSS12 CFAP43 DNAI3 DAW1	1.06e-04	200	104	5	cc906ff02fd335ff633b3b97afceb670494f910a
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM67 PRSS12 CFAP43 DNAI3 DAW1	1.06e-04	200	104	5	79e59ab31d3d3385b1b072dc75508af9546c2e1b
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM67 PRSS12 CFAP43 DNAI3 DAW1	1.06e-04	200	104	5	873def69bf55ccbfc944bc10c5afc06be019c312
Drug	methoxyphenamine	CYP2D7 CYP2D6 MSMB ADRB2	1.90e-07	12	103	4	CID000004117
Drug	paliperidone	HTR1B CYP2D7 CYP2D6 SLC6A3 IL21	2.66e-07	31	103	5	CID000115237
Drug	eptapirone	HTR1B CYP2D7 CYP2D6	8.93e-07	5	103	3	CID000208928
Drug	aripiprazole	HTR1B CYP2D7 CYP2D6 SLC6A3 ADRB2 IL21	1.25e-06	76	103	6	CID000060795
Drug	nitroguanidine	CYP2D7 CYP2D6 EMP1	1.78e-06	6	103	3	CID000011174
Drug	RI-331	ERVK-6 CYP2D7 CYP2D6 MDM2 HDAC2	2.27e-06	47	103	5	CID000160754
Drug	duloxetine	HTR1B CYP2D7 CYP2D6 SLC6A3 IL21	2.80e-06	49	103	5	CID000060834
Drug	mirtazapine	HTR1B CYP2D7 CYP2D6 SLC6A3 ADRB2	4.56e-06	54	103	5	CID000004205
Drug	phenmetrazine	CYP2D7 CYP2D6 SLC6A3	4.95e-06	8	103	3	CID000004762
Drug	beta-site	CYP2D7 CYP2D6 ADRB2	4.95e-06	8	103	3	CID000003914
Drug	DArT	PDCD2 SEMA4C FZR1 PZP	5.47e-06	26	103	4	CID000091734
Drug	AC1O3M98	CYP2D7 CYP2D6 EMP1	7.41e-06	9	103	3	CID006332100
Drug	MAMP	FLII HTR1B CYP2D7 CYP2D6 SLC6A3 ADRB2 CSMD1	8.35e-06	160	103	7	CID000001206
Drug	prochlorperazine	PDCD2 HTR1B CYP2D7 CYP2D6	8.60e-06	29	103	4	CID000004917
Drug	alprenolol	PDCD2 HTR1B CYP2D7 CYP2D6 ADRB2	1.06e-05	64	103	5	CID000002119
Drug	vindoline	CYP2D7 CYP2D6 SLC6A3	1.44e-05	11	103	3	CID000016596
Drug	(Z) Fluvoxamine	HTR1B CYP2D7 CYP2D6 SLC6A3 SLC45A2	1.53e-05	69	103	5	CID000003404
Drug	l-Lobeline	FLII CYP2D7 CYP2D6 SLC6A3	1.65e-05	34	103	4	CID000003945
Drug	2-Tbmbfd	CYP2D7 CYP2D6 SLC45A2	1.92e-05	12	103	3	CID000126928
Drug	atenolol	BRIP1 HTR1B CYP2D7 CYP2D6 ADRB2 LPA	1.96e-05	122	103	6	CID000002249
Drug	cupreidine	CYP2D7 CYP2D6	2.03e-05	2	103	2	CID000051196
Drug	a-40	MSMB LPA	2.03e-05	2	103	2	CID000200350
Drug	3-methoxyphenethylamine	CYP2D7 CYP2D6	2.03e-05	2	103	2	CID000074866
Drug	bisoprolol	PDCD2 CYP2D7 CYP2D6 ADRB2	2.33e-05	37	103	4	CID000002405
Drug	bergaptol	CYP2D7 CYP2D6 LYST	2.49e-05	13	103	3	CID005280371
Drug	almotriptan	HTR1B CYP2D7 CYP2D6 IL21	2.59e-05	38	103	4	CID000123606
Drug	Guanfacine hydrochloride [29110-48-3]; Up 200; 14.2uM; MCF7; HT_HG-U133A	LAMB4 SLC35G2 MDM2 FZR1 LPA WDFY3 AGBL2	3.00e-05	195	103	7	5256_UP
Drug	doxepin	CYP2D7 CYP2D6 NRN1 SLC6A3	3.18e-05	40	103	4	CID000003158
Drug	Sulfamethizole [144-82-1]; Up 200; 14.8uM; HL60; HT_HG-U133A	GPR15 THSD7A MDM2 SEMA4C FZR1 KCNQ1 MMP16	3.31e-05	198	103	7	2536_UP
Drug	desvenlafaxine	CYP2D7 CYP2D6 SLC6A3 IL21	3.52e-05	41	103	4	CID000125017
Drug	mianserin	HTR1B CYP2D7 CYP2D6 SLC6A3 ADRB2	4.73e-05	87	103	5	CID000004184
Drug	alpha-hydroxymetoprolol	PDCD2 CYP2D7 CYP2D6	4.82e-05	16	103	3	CID000114962
Drug	fluparoxan	HTR1B ADRB2 SLC45A2	4.82e-05	16	103	3	CID000072036
Drug	Kytril	FLII HTR1B CYP2D7 CYP2D6	5.10e-05	45	103	4	CID000003510
Drug	ipratropium bromide	HTR1B CYP2D7 CYP2D6 ADRB2	5.57e-05	46	103	4	CID000003746
Drug	bufuralol	CYP2D7 CYP2D6 ADRB2 SLC45A2	5.57e-05	46	103	4	CID000071733
Drug	bunitrolol	HTR1B CYP2D7 CYP2D6	5.84e-05	17	103	3	CID000002473
Drug	2,4,6-trimethylbenzaldoxime	CYP2D7 CYP2D6	6.06e-05	3	103	2	CID000283782
Drug	O-demethyl encainide	CYP2D7 CYP2D6	6.06e-05	3	103	2	CID000054736
Drug	chlorpromazine N-oxide	CYP2D7 CYP2D6	6.06e-05	3	103	2	CID000443037
Drug	Iodocyanopindolol	HTR1B ADRB2	6.06e-05	3	103	2	ctd:D020120
Drug	dermatan sulfate	FN1 HLA-DMB NEU3 LYST HABP2 TNXB DSE	6.46e-05	220	103	7	CID000032756
Drug	2cgu	CYP2D7 CYP2D6 FN1 SLC45A2	6.60e-05	48	103	4	CID003506204
Drug	sulfamethazine	GPR15 CYP2D7 CYP2D6 SLC45A2	6.60e-05	48	103	4	CID000005327
Drug	isoflavone	MDM2 LYST RRAGA LPA SLC45A2 MMP16	7.50e-05	155	103	6	CID000072304
Drug	sertindole	HTR1B CYP2D7 CYP2D6 HDAC2	7.75e-05	50	103	4	CID000060149
Drug	1-PP	HTR1B CYP2D7 CYP2D6	8.27e-05	19	103	3	CID000088747
Drug	m-tyramine	CYP2D7 CYP2D6 SLC6A3	8.27e-05	19	103	3	CID000011492
Drug	trazodone	HTR1B CYP2D7 CYP2D6 SLC6A3	8.38e-05	51	103	4	CID000005533
Drug	paraxanthine	CYP2D7 CYP2D6 SLC6A3 SLC45A2	9.75e-05	53	103	4	CID000004687
Drug	minaprine	BRIP1 HTR1B CYP2D7 CYP2D6	1.05e-04	54	103	4	CID000004199
Drug	chondroitin sulfate	FN1 NEU3 LYST ADAMTS16 ADAMTS18 HABP2 MMP16 TNXB DSE	1.09e-04	413	103	9	CID000024766
Drug	DAS-431	HTR1B SLC6A3 ADRB2	1.13e-04	21	103	3	CID000166543
Drug	theophylline	ERVK-6 HTR1B CYP2D7 CYP2D6 ADRB2 LPA HDAC2	1.14e-04	241	103	7	CID000002153
Drug	metoprolol	PDCD2 HTR1B CYP2D7 CYP2D6 ADRB2	1.16e-04	105	103	5	CID000004171
Drug	Pindolol	HTR1B ADRB2	1.21e-04	4	103	2	DB00960
Drug	desethylaprindine	CYP2D7 CYP2D6	1.21e-04	4	103	2	CID000162697
Drug	4,4'-difluorobenzophenone	CYP2D7 CYP2D6	1.21e-04	4	103	2	CID000009582
Drug	cyanopindolol	HTR1B ADRB2	1.21e-04	4	103	2	ctd:C047975
Drug	Z-10	CYP2D7 CYP2D6	1.21e-04	4	103	2	CID000477529
Drug	1-(1-phenylcyclohexyl)-4-piperidinol	CYP2D7 CYP2D6	1.21e-04	4	103	2	CID000098840
Drug	AC1L9N39	CYP2D7 CYP2D6 HLA-DMB	1.30e-04	22	103	3	CID000449406
Drug	acebutolol	CYP2D7 CYP2D6 ADRB2	1.30e-04	22	103	3	CID000001978
Drug	Propranolol	HTR1B CYP2D6 FN1 ADRB2 KCNQ1	1.38e-04	109	103	5	ctd:D011433
Drug	nortriptyline	CYP2D7 CYP2D6 SLC6A3 ADRB2	1.48e-04	59	103	4	CID000004543
Drug	perazine	PDCD2 CYP2D7 CYP2D6	1.49e-04	23	103	3	CID000004744
Drug	et E	PDCD2 LYST SLC6A3	1.49e-04	23	103	3	CID000090263
Drug	agomelatine	HTR1B IL21 SLC45A2	1.49e-04	23	103	3	CID000082148
Drug	carbamazepine	PDCD2 HTR1B CYP2D7 CYP2D6 SLC6A3 LPA	1.65e-04	179	103	6	CID000002554
Drug	compound 23	ERVK-6 CYP2D7 CYP2D6	1.70e-04	24	103	3	CID000447410
Drug	moclobemide	HTR1B CYP2D7 CYP2D6 ADRB2	1.80e-04	62	103	4	CID000004235
Drug	pindolol	HTR1B CYP2D7 CYP2D6 ADRB2	1.92e-04	63	103	4	CID000004828
Drug	Propranolol	HTR1B ADRB2	2.01e-04	5	103	2	DB00571
Drug	N-(2-amino-3-methyl-n-butyl)-3-((bis-4-fluorophenyl)methoxy)tropane	CYP2D6 SLC6A3	2.01e-04	5	103	2	ctd:C534983
Drug	fluorocarazolol	HTR1B ADRB2	2.01e-04	5	103	2	CID000133038
Drug	L-754,394	CYP2D7 CYP2D6	2.01e-04	5	103	2	CID005481990
Drug	aminopyrazine	ADRB2 TNXB	2.01e-04	5	103	2	CID000078747
Drug	4-hydroxyochratoxin A	CYP2D7 CYP2D6	2.01e-04	5	103	2	CID000114713
Drug	Koe 1801	CYP2D7 CYP2D6	2.01e-04	5	103	2	CID000129632
Drug	Bopindolol	HTR1B ADRB2	2.01e-04	5	103	2	DB08807
Drug	2Cmp	CYP2D7 CYP2D6	2.01e-04	5	103	2	CID000023392
Drug	oxosparteine	CYP2D7 CYP2D6	2.01e-04	5	103	2	CID000097492
Drug	threohydrobupropion	CYP2D7 CYP2D6	2.01e-04	5	103	2	CID000000445
Drug	fenproporex	CYP2D7 CYP2D6	2.01e-04	5	103	2	CID000061810
Drug	desipramine	HTR1B CYP2D7 CYP2D6 SLC6A3 ADRB2 SLC45A2	2.15e-04	188	103	6	CID000002995
Drug	alpha-methyldopamine	CYP2D7 CYP2D6 ADRB2	2.17e-04	26	103	3	CID000017005
Drug	citalopram	HTR1B CYP2D7 CYP2D6 SLC6A3 ADRB2	2.17e-04	120	103	5	CID000002771
Drug	3-isoreserpine	HTR1B FN1 SLC6A3 ADRB2 SLC45A2 SORL1	2.28e-04	190	103	6	CID000005052
Drug	mexiletine	HTR1B CYP2D7 CYP2D6 KCNQ1	2.30e-04	66	103	4	CID000004178
Drug	Amitryptiline hydrochloride [549-18-8]; Up 200; 12.8uM; PC3; HT_HG-U133A	GPR15 NEU3 FZR1 ADRB2 MUC2 ZNF639	2.41e-04	192	103	6	6353_UP
Drug	fluperlapine	FLII CYP2D7 CYP2D6	2.43e-04	27	103	3	CID000049381
Drug	sulfamethoxazole	CYP2D7 CYP2D6 EMP1	2.43e-04	27	103	3	CID000005329
Drug	Pyrilamine maleate [59-33-6]; Up 200; 10uM; PC3; HT_HG-U133A	LAMB4 HTR1B MDM2 FZR1 ADRB2 MMP16	2.55e-04	194	103	6	5869_UP
Drug	AC1NSKJI	HTR1B ADRB2 KCNQ1 PZP	2.58e-04	68	103	4	CID005311391
Drug	AC1L89QG	CYP2D7 CYP2D6 SLC6A3 DSE	2.58e-04	68	103	4	CID000323970
Drug	rapamycin; Up 200; 0.1uM; ssMCF7; HG-U133A	NMNAT2 GPR15 THSD7A FN1 SLC45A2 FAM149B1	2.62e-04	195	103	6	402_UP
Drug	Carbarsone [121-59-5]; Up 200; 15.4uM; PC3; HT_HG-U133A	FN1 PRSS12 NRN1 FZR1 MMP16 ZNF639	2.62e-04	195	103	6	3991_UP
Drug	Isometheptene mucate; Down 200; 8.2uM; PC3; HT_HG-U133A	CLDN15 MDM2 SEMA4C FZR1 MUC2 ZNF639	2.70e-04	196	103	6	5082_DN
Drug	Trimethoprim [738-70-5]; Up 200; 13.8uM; PC3; HT_HG-U133A	LAMB4 HTR1B MDM2 NEURL1 SLC45A2 MMP16	2.70e-04	196	103	6	3678_UP
Drug	Isocarboxazid [59-63-2]; Up 200; 17.2uM; HL60; HT_HG-U133A	FN1 FZR1 NEURL1 KCNQ1 EMP1 MMP16	2.70e-04	196	103	6	2562_UP
Disease	solanidine measurement	CYP2D7 CYP2D6	7.21e-05	4	103	2	EFO_0800966
Disease	Chediak-Higashi syndrome (implicated_via_orthology)	LYST WDFY3	7.21e-05	4	103	2	DOID:2935 (implicated_via_orthology)
Disease	TEMPS-A questionnaire	XKR9 CSMD1 SHISA6	8.98e-05	25	103	3	EFO_0004783
Disease	Amphetamine-Related Disorders	HTR1B CYP2D6 SLC6A3 CSMD1	1.41e-04	75	103	4	C0236733
Disease	Amphetamine Abuse	HTR1B CYP2D6 SLC6A3 CSMD1	1.41e-04	75	103	4	C0236807
Disease	Amphetamine Addiction	HTR1B CYP2D6 SLC6A3 CSMD1	1.41e-04	75	103	4	C0236804
Disease	melanoma	SLC35G2 MDM2 CD163L1 CRYBG1 SLC45A2 HDAC2	2.40e-04	248	103	6	C0025202
Disease	Tremor, Neonatal	CYP2D6 ADRB2	4.28e-04	9	103	2	C0235843
Disease	ulcerative colitis (biomarker_via_orthology)	ADRB2 MUC2	4.28e-04	9	103	2	DOID:8577 (biomarker_via_orthology)
Disease	Tremor, Perioral	CYP2D6 ADRB2	4.28e-04	9	103	2	C0235078
Disease	Nerve Tremors	CYP2D6 ADRB2	4.28e-04	9	103	2	C0235083
Disease	Tremor, Limb	CYP2D6 ADRB2	4.28e-04	9	103	2	C0235081
Disease	Tremor, Muscle	CYP2D6 ADRB2	4.28e-04	9	103	2	C0235082
Disease	Senile Tremor	CYP2D6 ADRB2	4.28e-04	9	103	2	C0149840
Disease	Pill Rolling Tremor	CYP2D6 ADRB2	4.28e-04	9	103	2	C0751564
Disease	Tremor, Semirhythmic	CYP2D6 ADRB2	4.28e-04	9	103	2	C0751565
Disease	Action Tremor	CYP2D6 ADRB2	4.28e-04	9	103	2	C0234376
Disease	Passive Tremor	CYP2D6 ADRB2	4.28e-04	9	103	2	C0234377
Disease	Static Tremor	CYP2D6 ADRB2	4.28e-04	9	103	2	C0234378
Disease	Resting Tremor	CYP2D6 ADRB2	4.28e-04	9	103	2	C0234379
Disease	Intermittent Tremor	CYP2D6 ADRB2	4.28e-04	9	103	2	C0234372
Disease	Fine Tremor	CYP2D6 ADRB2	4.28e-04	9	103	2	C0234373
Disease	Coarse Tremor	CYP2D6 ADRB2	4.28e-04	9	103	2	C0234374
Disease	Massive Tremor	CYP2D6 ADRB2	4.28e-04	9	103	2	C0234375
Disease	Persistent Tremor	CYP2D6 ADRB2	4.28e-04	9	103	2	C0234370
Disease	Continuous Tremor	CYP2D6 ADRB2	4.28e-04	9	103	2	C0234371
Disease	Darkness Tremor	CYP2D6 ADRB2	4.28e-04	9	103	2	C0234381
Disease	Involuntary Quiver	CYP2D6 ADRB2	4.28e-04	9	103	2	C1527384
Disease	Saturnine Tremor	CYP2D6 ADRB2	4.28e-04	9	103	2	C0040827
Disease	mean arterial pressure, response to high sodium diet	KCNQ1 CSMD1	5.33e-04	10	103	2	EFO_0005401, EFO_0006340
Disease	pneumonia (implicated_via_orthology)	ADRB2 MUC2	5.33e-04	10	103	2	DOID:552 (implicated_via_orthology)
Disease	Early Pregnancy Loss	FN1 CD164 HABP2 EMP1	5.88e-04	109	103	4	C3830362
Disease	Spontaneous abortion	FN1 CD164 HABP2 EMP1	5.88e-04	109	103	4	C0000786
Disease	Miscarriage	FN1 CD164 HABP2 EMP1	5.88e-04	109	103	4	C4552766
Disease	Abortion, Tubal	FN1 CD164 HABP2 EMP1	5.88e-04	109	103	4	C0000822
Disease	Tremor	CYP2D6 ADRB2	6.50e-04	11	103	2	C0040822
Disease	Intestinal Neoplasms	KCNQ1 MUC2	7.78e-04	12	103	2	C0021841
Disease	Intestinal Cancer	KCNQ1 MUC2	7.78e-04	12	103	2	C0346627
Disease	squamous cell carcinoma, multiple keratinocyte carcinoma susceptibility measurement, basal cell carcinoma	BRIP1 CSMD1	9.18e-04	13	103	2	EFO_0000707, EFO_0004193, EFO_0007932
Disease	Bardet-Biedl Syndrome	TMEM67 CFAP418	9.18e-04	13	103	2	C0752166
Disease	familial atrial fibrillation (is_implicated_in)	NUP155 KCNQ1	1.07e-03	14	103	2	DOID:0050650 (is_implicated_in)
Disease	unipolar depression, mood disorder	THSD7A ARFGAP2 EYS AGBL2	1.27e-03	134	103	4	EFO_0003761, EFO_0004247
Disease	Malignant neoplasm of breast	RCE1 BRIP1 CYP2D6 FN1 KBTBD8 MDM2 EIF6 SLC6A3 DAW1 OCLN SORL1	1.33e-03	1074	103	11	C0006142
Disease	cholangiocarcinoma (is_marker_for)	MDM2 ADRB2 MUC2	1.47e-03	64	103	3	DOID:4947 (is_marker_for)
Disease	plasma beta-amyloid 1-40 measurement	KCNQ1 PDS5A	1.59e-03	17	103	2	EFO_0005659
Disease	ischemia (biomarker_via_orthology)	HTR1B MUC2	1.78e-03	18	103	2	DOID:326 (biomarker_via_orthology)
Disease	serum alanine aminotransferase measurement, response to combination chemotherapy	PDCD2 HTR1B RNF213	1.99e-03	71	103	3	EFO_0004735, EFO_0007965
Disease	cholesteryl ester measurement	HGFAC SLC35G2 EYS LPA AGBL2	2.11e-03	257	103	5	EFO_0010351
Disease	freckles	EIF6 SLC45A2	2.20e-03	20	103	2	EFO_0003963
Disease	attention deficit hyperactivity disorder (is_implicated_in)	HTR1B SLC6A3	2.20e-03	20	103	2	DOID:1094 (is_implicated_in)
Disease	asthma (is_implicated_in)	CYP2D6 ADRB2 IL21 MUC2	2.27e-03	157	103	4	DOID:2841 (is_implicated_in)
Disease	lung cancer	BRIP1 CSMD1	2.43e-03	21	103	2	MONDO_0008903
Disease	monounsaturated fatty acids; 16:1, 18:1 measurement	HGFAC SEC31B LPA	2.60e-03	78	103	3	EFO_0022187
Disease	anxiety disorder (implicated_via_orthology)	HTR1B HDAC2	2.66e-03	22	103	2	DOID:2030 (implicated_via_orthology)
Disease	ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)	NUP155 KCNQ1	2.66e-03	22	103	2	C1843687
Disease	triacylglycerol 58:9 measurement	CSMD1 TNXB	2.66e-03	22	103	2	EFO_0010443
Disease	glomerular filtration rate, renal transplant outcome measurement, donor genotype effect measurement	EMP1 CSMD1	2.66e-03	22	103	2	EFO_0005199, EFO_0005208, EFO_0007892
Disease	Mood Disorders	HTR1B CYP2D6 SLC6A3 HDAC2	2.89e-03	168	103	4	C0525045
Disease	QRS duration, response to sulfonylurea	MDN1 CSMD1	2.91e-03	23	103	2	EFO_0005055, EFO_0007922
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	CYP2D7 CYP2D6	3.17e-03	24	103	2	EFO_0003761, EFO_0005658

Protein segments in the cluster

Peptide	Gene	Start	Entry
VCDFWLSSDITCCTA	HTR1B	121	P28222
SCCIPSTNLAYTAAW	ADGRF3	356	Q8IZF5
CEFWTSIDVLCVTAS	ADRB2	106	P07550
SNYASWEVAEICTLC	AKR7A2	171	O43488
WLEDCACVSKIYLNT	CFAP43	416	Q8NDM7
VNNCWLCISLSSSAY	nan	61	Q9N2K0
ANNCWLCISLSSSAY	nan	61	Q9N2J8
HYWQDCSSKNTLCSE	ERVK13-1	96	Q9NX77
CDWNTSDFCITPQIY	ERVK-8	551	Q902F8
YQWDSLTPLCQAVSC	CSMD1	2481	Q96PZ7
SLQLFWVCAYCTSIC	CTC1	1036	Q2NKJ3
FQEIYSECNTWDCIA	CARNMT1	296	Q8N4J0
SECNTWDCIATCFFI	CARNMT1	301	Q8N4J0
RTDCAYVVCASIWFI	GPR15	146	P49685
TRAYACQCSWRTIEE	CFAP418	176	Q96NL8
WASITYGVFLCIDCS	ARFGAP2	36	Q8N6H7
CWFVAACSSLASRES	CAPN5	81	O15484
ISCTGNESALWDCTY	CD163L1	436	Q9NR16
LVTCSADCTICFWDI	DNAI3	511	Q8IWG1
SYTWAIVRSECSVSC	ADAMTS16	871	Q8TE57
YTWSIVQSECSVSCG	ADAMTS18	876	Q8TE60
SYCICGNERQTLSWT	PZP	851	P20742
AWVKSYNICFELEDC	PDS5A	146	Q29RF7
CIAIFACVASTLAWD	OCLN	76	Q16625
YRNTCVEVSYIWECL	OVOS1	706	Q6IE37
WKNCTNISCSDSLSY	EMP1	41	P54849
LTETYCAEKWHSLCN	FGFBP3	236	Q8TAT2
VCDDGWTELNTYVVC	PRSS12	411	P56730
AASLIQTAWRCYAAE	KCNQ1	371	P51787
AFSEACWEVYVCSQH	MDN1	2386	Q9NU22
DTRCVYILDCWSDVF	FLII	771	Q13045
WCVAVYSLCFLATVA	MYADML2	196	A6NDP7
EKWDCESICSTYSNL	LTV1	346	Q96GA3
DQSFSYSCLCTLGWV	EYS	2951	Q5T1H1
VNTTCFWIECKDESY	CD164	76	Q04900
RVSLWTLCTATCGNY	ADAMTSL1	1671	Q8N6G6
VCEQFWCYSATLLLA	LINC02901	181	Q4VX62
TVCTWSQERACAYSS	ITGAE	1031	P38570
WVSVFSCLSLACSYV	RCE1	36	Q9Y256
DWGILAVFTCAESCS	PDCD2	311	Q16342
VNCSLSCTLEFYNWS	MUC2	4361	Q02817
SLEDWLCCEYLAEAT	PEAK3	446	Q6ZS72
CAEISSASFNWDCSL	DAW1	261	Q8N136
IDSCILLWLYSSCSQ	DSE	941	Q9UL01
NIKTVCTYWEDFHSC	NRN1	61	Q9NPD7
CTYWEDFHSCTVTAL	NRN1	66	Q9NPD7
EWQTDNCETCTCYET	MSMB	51	P08118
ALSWEYCRLEACESL	HGFAC	356	Q04756
CDWNTSDFCITPQIY	ERVK-7	1311	P63135
YFLWESAEACPLCTE	ELAPOR2	866	A8MWY0
CSTAACDREVSAWAT	NUP155	556	O75694
VECYDSRENCWTTVC	KBTBD8	411	Q8NFY9
VCCSLINWLEANAEY	BRIP1	441	Q9BX63
DWCAFCGLDTTSTEL	EIF6	201	P56537
VCGENVTCVEYAISW	PARP14	1431	Q460N5
GTCVYLWSACTSQVT	FZR1	206	Q9UM11
VKWEYCDVSACSAQD	HABP2	266	Q14520
TYCISFNKDLLTCWD	HLA-DMB	41	P28068
SCAVITGNWVYSEDC	KLRF2	171	D3W0D1
CDWNTSDFCITPQIY	ERVK-25	551	P61570
CDWNTSDFCITPQIY	ERVK-6	551	Q69384
WTCIAYSQLRDQCIV	FN1	506	P02751
QWVTEEAACLCAAFA	CYP2D6	151	P10635
DVETNCEWSAFSCFQ	IL21	66	Q9HBE4
CLTWTIQFPYDQDTC	AGBL2	376	Q5U5Z8
YCNLTRCSDAEWTAF	LPA	1011	P08519
VRWEYCNLTQCLVTE	LPA	1121	P08519
SCATDSLGVYNCWEF	CLDN15	51	P56746
YQVTSCAWVPDSCQL	LYST	3566	Q99698
LWSSDVICNCLQGYT	LAMB4	931	A4D0S4
CQEICWEPTSCQTSY	KRTAP13-2	56	Q52LG2
CVLQAWVEDCYAVDF	KNDC1	1321	Q76NI1
CDWNTSDFCITPQIY	HERVK_113	551	Q902F9
NGEVCWKTITDCVSY	ERMARD	41	Q5T6L9
CIEVFSDIQDCSSWS	CRYBG1	1036	Q9Y4K1
RCWTYETAVALDCEI	HDAC2	311	Q92769
WLAISNSFCNCVIYS	GPR21	291	Q99679
LTTDCLEDSLLTCYW	CGRRF1	86	Q99675
LEDSLLTCYWGCSVQ	CGRRF1	91	Q99675
CWGLCINSVFSSLYS	SLC45A2	371	Q9UMX9
LAYVFDSVWCKVVSC	FAM149B1	271	Q96BN6
ACWVYANLTSCQALG	TMEM67	236	Q5HYA8
CQYTFWDQCESTVAA	KIF13A	891	Q9H1H9
WSDEANCTAIYHTCE	SORL1	1186	Q92673
NQVLFCSETIARCWY	RAPGEF6	61	Q8TEU7
CQQDCIVSEFSAWSE	THSD7A	191	Q9UPZ6
EATCNLWCVYVHETV	TCAF1	776	Q9Y4C2
DYSESIDWCISLICD	PWWP3B	461	Q5H9M0
ETWSYLIAICVCSTA	SLC35G2	316	Q8TBE7
CECYISIADWAAVQE	SMG1	1191	Q96Q15
EISLADYWKCTSCNE	MDM2	296	Q00987
VAAAASAAVTYETCW	SHISA6	81	Q6ZSJ9
CKDYVSIFVCSDWQL	WRAP73	156	Q9P2S5
YVCSGSVERLVECWA	SEC31B	686	Q9NQW1
YCAWSVNTSRCVAVG	SEMA4C	516	Q9C0C4
WATYYESCISSEQSC	SSH1	206	Q8WYL5
QWVTEEAACLCAAFA	CYP2D7	151	A0A087X1C5
LCFIYSQDAGCSWSE	NEU3	126	Q9UQ49
TLCLESQVLSGYDWC	SLC35G4	146	P0C7Q5
LSQITAYCNSCWDTK	RNF213	971	Q63HN8
WACCLRYIFNSSVQE	STIL	276	Q15468
DHLYWCEQCDVQFSS	ZNF639	286	Q9UID6
TVYECLSEWGQILCA	WDFY3	3071	Q8IZQ1
LLWILCATVCGTEQY	MMP16	26	P51512
QWSDECTICYEHAVD	NEURL1	516	O76050
ECACFRTSIWDETLY	RRAGA	156	Q7L523
CEASVWIDAATQVCF	SLC6A3	306	Q01959
ACYCSTEVTQAIWDG	TBC1D23	206	Q9NUY8
ICWEGYVSEDCSIRT	TNXB	606	P22105
SVFSCSVCANSFVDW	ZBTB39	506	O15060
CTFAYCQEEIDVWTL	ZC3H7A	521	Q8IWR0
VTCQCLEVVGAYVSW	XPOT	201	O43592
FNTLISYCCQSWIVS	TARBP1	1036	Q13395
SYCCQSWIVSASNVS	TARBP1	1041	Q13395
QSYQLWSSVCSTLCV	TERB1	171	Q8NA31
SCCAISWSTVDYQVA	XKR9	171	Q5GH70
ECYQDTWQTTCSVLE	NMNAT2	86	Q9BZQ4