Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	actin filament organization	KBTBD13 MAGEL2 DBN1 GPR65 CORO1C ARAP1 SVIL	3.48e-05	509	38	7	GO:0007015
GeneOntologyBiologicalProcess	supramolecular fiber organization	KBTBD13 MAGEL2 DBN1 GPR65 OCLN DSP CORO1C ARAP1 SVIL	4.63e-05	957	38	9	GO:0097435
GeneOntologyBiologicalProcess	positive regulation of cellular component organization	SETDB1 PTPN22 ICE1 MAGEL2 SHCBP1L DBN1 GPR65 OCLN CORO1C ARAP1	1.34e-04	1366	38	10	GO:0051130
GeneOntologyBiologicalProcess	regulation of actin filament-based process	MAGEL2 DBN1 GPR65 DSP ARAP1 SVIL	1.38e-04	438	38	6	GO:0032970
GeneOntologyBiologicalProcess	regulation of supramolecular fiber organization	MAGEL2 DBN1 GPR65 OCLN ARAP1 SVIL	1.38e-04	438	38	6	GO:1902903
GeneOntologyBiologicalProcess	actin filament-based process	KBTBD13 MAGEL2 DBN1 GPR65 DSP CORO1C ARAP1 SVIL	2.12e-04	912	38	8	GO:0030029
GeneOntologyBiologicalProcess	regulation of actin filament organization	MAGEL2 DBN1 GPR65 ARAP1 SVIL	2.13e-04	300	38	5	GO:0110053
GeneOntologyBiologicalProcess	regulation of cellular component biogenesis	SETDB1 PTPN22 ICE1 DBN1 GPR65 OCLN CORO1C ARAP1 SVIL	2.43e-04	1189	38	9	GO:0044087
Domain	-	DBN1 SVIL	1.03e-03	24	37	2	3.40.20.10
Domain	ADF-H/Gelsolin-like_dom	DBN1 SVIL	1.03e-03	24	37	2	IPR029006
Domain	Spectrin_repeat	TRIO DSP	1.50e-03	29	37	2	IPR002017
Domain	Spectrin/alpha-actinin	TRIO DSP	1.82e-03	32	37	2	IPR018159
Domain	SPEC	TRIO DSP	1.82e-03	32	37	2	SM00150
Domain	GDS_CDC24_CS	ALS2 TRIO	2.70e-03	39	37	2	IPR001331
Domain	BTB	KBTBD13 KLHL3 BTBD10	3.87e-03	160	37	3	PS50097
Domain	BTB	KBTBD13 KLHL3 BTBD10	5.38e-03	180	37	3	SM00225
Domain	BTB/POZ_dom	KBTBD13 KLHL3 BTBD10	5.80e-03	185	37	3	IPR000210
Domain	Kelch	KBTBD13 KLHL3	5.89e-03	58	37	2	SM00612
Domain	SKP1/BTB/POZ	KBTBD13 KLHL3 BTBD10	6.15e-03	189	37	3	IPR011333
Domain	Ig_I-set	CNTN3 SDK2 TRIO	6.24e-03	190	37	3	IPR013098
Domain	I-set	CNTN3 SDK2 TRIO	6.24e-03	190	37	3	PF07679
Domain	DH_1	ALS2 TRIO	6.91e-03	63	37	2	PS00741
Domain	DH_2	ALS2 TRIO	8.47e-03	70	37	2	PS50010
Domain	RhoGEF	ALS2 TRIO	8.47e-03	70	37	2	PF00621
Domain	Kelch_1	KBTBD13 KLHL3	8.47e-03	70	37	2	PF01344
Domain	Kelch_1	KBTBD13 KLHL3	8.47e-03	70	37	2	IPR006652
Domain	DH-domain	ALS2 TRIO	8.71e-03	71	37	2	IPR000219
Domain	-	ALS2 TRIO	8.71e-03	71	37	2	1.20.900.10
Domain	IGc2	CNTN3 SDK2 TRIO	1.12e-02	235	37	3	SM00408
Domain	Ig_sub2	CNTN3 SDK2 TRIO	1.12e-02	235	37	3	IPR003598
Pathway	REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS	OCLN DSP	1.70e-04	10	28	2	MM14956
Pathway	REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS	OCLN DSP	2.07e-04	11	28	2	M9990
Pubmed	NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.	DBN1 DSP CORO1C	2.72e-06	25	38	3	30309841
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	MARF1 EIF3B DBN1 DSP EIF4A2	1.15e-05	272	38	5	31010829
Pubmed	Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization.	OCLN DSP	1.74e-05	6	38	2	25617501
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	EIF3B MTAP DBN1 DSP SYAP1 CORO1C EIF4A2 SVIL	2.80e-05	1149	38	8	35446349
Pubmed	NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.	TRHDE EIF3B DBN1 DSP CORO1C	3.02e-05	333	38	5	32665550
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	TTC7A DBN1 OCLN ZFYVE16 SYAP1 SVIL	3.18e-05	565	38	6	25468996
Pubmed	Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths.	LAMB2 OCLN	3.24e-05	8	38	2	10482238
Pubmed	The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice.	OCLN DSP	4.16e-05	9	38	2	18703497
Pubmed	DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.	DBN1 DSP SVIL	4.57e-05	63	38	3	37052853
Pubmed	MEK kinase 1 regulates c-Jun phosphorylation in the control of corneal morphogenesis.	OCLN DSP	1.05e-04	14	38	2	14627958
Pubmed	Dual role of Fam208a during zygotic cleavage and early embryonic development.	SETDB1 SVIL	1.38e-04	16	38	2	34216590
Pubmed	Study of FOXO1-interacting proteins using TurboID-based proximity labeling technology.	DBN1 DSP CORO1C GPR179	1.42e-04	243	38	4	36964488
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	EIF3B MTAP DBN1 DSP SYAP1 SVIL	1.79e-04	774	38	6	15302935
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	OCLN ZFYVE16 SYAP1 SVIL	1.93e-04	263	38	4	34702444
Pubmed	Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier.	OCLN DSP	1.96e-04	19	38	2	18166659
Pubmed	Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.	PTPN22 ARAP1	2.18e-04	20	38	2	31591574
Pubmed	The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins.	SETDB1 GLI1	2.18e-04	20	38	2	14611647
Pubmed	New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity.	OCLN DSP	2.90e-04	23	38	2	18809908
Pubmed	Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor.	OCLN DSP	2.90e-04	23	38	2	19841136
Pubmed	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.	DBN1 CORO1C SVIL	2.95e-04	118	38	3	27377895
Pubmed	Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton's tyrosine kinase.	DBN1 CORO1C	3.16e-04	24	38	2	21080425
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	EIF3B DBN1 DSP CORO1C ZCCHC3	3.19e-04	551	38	5	34728620
Pubmed	Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.	OCLN DSP	3.43e-04	25	38	2	23132931
Pubmed	Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development.	OCLN DSP	3.43e-04	25	38	2	31410202
Pubmed	Epidermal development requires ninein for spindle orientation and cortical microtubule organization.	OCLN DSP	3.72e-04	26	38	2	30923192
Pubmed	αE-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation.	DSP GLI1	3.72e-04	26	38	2	28793255
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	EIF3B DBN1 DSP CORO1C ZCCHC3 SVIL BTBD10	3.74e-04	1257	38	7	36526897
Pubmed	Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.	LAMB2 DBN1 DSP	4.00e-04	131	38	3	28634551
Pubmed	Genomic architecture of Shh-dependent cochlear morphogenesis.	DSP GLI1	4.32e-04	28	38	2	31488567
Pubmed	TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.	EIF3B ZFYVE16	4.32e-04	28	38	2	29653964
Pubmed	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.	EIF3B ZFYVE16 CORO1C ZCCHC3	4.40e-04	327	38	4	15592455
Pubmed	The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.	EIF3B DBN1 CORO1C SVIL	4.45e-04	328	38	4	23398456
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	EIF3B TRIO CIAO1 SVIL	4.66e-04	332	38	4	37433992
Pubmed	Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.	LAMB2 MTAP DBN1 EIF4A2	5.15e-04	341	38	4	29791485
Pubmed	WNT5a-ROR Signaling Is Essential for Alveologenesis.	DBN1 GLI1	5.30e-04	31	38	2	32046118
Pubmed	Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate.	OCLN GLI1	5.30e-04	31	38	2	36362374
Pubmed	E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer via Destabilizing F-Actin Capping Protein CAPZA1.	DBN1 DSP	5.30e-04	31	38	2	33777788
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	LAMB2 EIF3B DBN1 DSP CORO1C SVIL	5.32e-04	949	38	6	36574265
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	EIF3B MTAP DBN1 CORO1C	5.32e-04	344	38	4	30333137
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	EIF3B DBN1 DSP CORO1C SVIL	5.71e-04	626	38	5	33644029
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	EXOG DBN1 TRIO CORO1C EIF4A2 SVIL	5.74e-04	963	38	6	28671696
Pubmed	Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia.	DBN1 CORO1C ZCCHC3	6.41e-04	154	38	3	36490346
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	DBN1 CORO1C SVIL	6.65e-04	156	38	3	29961565
Pubmed	Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z.	DBN1 DSP CORO1C	7.03e-04	159	38	3	34537242
Pubmed	Human transcription factor protein interaction networks.	MARF1 SETDB1 EIF3B DBN1 CORO1C ZCCHC3 SVIL	8.03e-04	1429	38	7	35140242
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PTPN22 TRIO ZFYVE16 DSP CORO1C SVIL	8.97e-04	1049	38	6	27880917
Pubmed	Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4.	DBN1 CORO1C	1.02e-03	43	38	2	30026490
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KBTBD13 KLHL3 BTBD10	1.40e-03	134	30	3	861
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	CNTN3 SDK2 TRIO	2.36e-03	161	30	3	593
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	MARF1 OCLN ZFYVE16	3.28e-03	181	30	3	694
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ALS2 TRIO	5.34e-03	66	30	2	722
Disease	polymyositis	PTPN22 SDK2	2.87e-04	20	37	2	EFO_0003063
Disease	gestational diabetes	HKDC1 ARAP1	3.81e-04	23	37	2	EFO_0004593
Disease	Crohn's disease (is_implicated_in)	PTPN22 OCLN	6.51e-04	30	37	2	DOID:8778 (is_implicated_in)
Disease	myositis	PTPN22 SDK2	1.10e-03	39	37	2	EFO_0000783

Protein segments in the cluster

Peptide	Gene	Start	Entry
VYCTGVSLLDEDVWE	TRHDE	856	Q9UKU6
VVLTDDDVVDWDEEY	BTBD10	311	Q9BSF8
WLEEAECRDQYSVIF	EIF3B	296	P55884
DNDREEDIYWECVLR	ALS2	1496	Q96Q42
DQCYDDIRVSRVTWD	CORO1C	21	Q9ULV4
YDCWKEHEEAVSVDR	MTAP	221	Q13126
GESCDELEEDWIREY	OCLN	406	Q16625
LELIWDVRCYQEDDS	PTPN22	206	Q9Y2R2
DYCAEDQTIESWREE	LEMD1	136	Q68G75
YLEALAECEWEDTDE	MAGEL2	1216	Q9UJ55
NDIRESSVEEDVEWY	GPR179	116	Q6PRD1
HWDDVVCESRYSEIE	LAMB2	196	P55268
KREPESVYETDCRWD	GLI1	226	P08151
YCRELTERFEDVWVV	EXOG	181	Q9Y2C4
AYEEVIREESAADWA	DBN1	16	Q16643
TCEEWIESEEDDYSL	ICE1	1231	Q9Y2F5
INDCEEEELLYDWSD	DSP	286	P15924
REEWKLDTLCDLYET	EIF4A2	256	Q14240
DWDVTEYGVCELIDI	MARF1	1211	Q9Y4F3
SVECYDFEEDRWDQI	KLHL3	316	Q9UH77
VERDYTIEDLEEWTE	SDK2	1156	Q58EX2
DVEIAVEDSLYWECR	CNTN3	326	Q9P232
EEEEENVQSEWRLYC	SVIL	1871	O95425
EYEVTEEDWETIYPC	RNF8	121	O76064
WREHCEDEETLCEYA	BMT2	61	Q1RMZ1
CIDDIWTRYDTEVDE	HKDC1	716	Q2TB90
DKAREDYSESIDWCI	PWWP3B	456	Q5H9M0
DWDDEESCENYTALI	SHCBP1L	266	Q9BZQ2
EYEVVTESEKRDENW	SYAP1	326	Q96A49
WEDIEDISCRDFIEE	SETDB1	321	Q15047
EKDYWTCFEVNEREE	ARAP1	1216	Q96P48
VWEVDEEDEYECVSV	CIAO1	131	O76071
DDTVKLYREEEDDWV	CIAO1	171	O76071
LYREEEDDWVCCATL	CIAO1	176	O76071
LRVYEEKREQEDCWE	ZCCHC3	226	Q9NUD5
TLCYLDEEEDAWRTL	KBTBD13	176	C9JR72
ECLEERCSWEEAREY	PRRG2	66	O14669
WEDETVVEYCDAEKS	GPR65	151	Q8IYL9
EREEEVITCFERASW	TTC7A	191	Q9ULT0
EEWIEIRVAFEDYIS	TRIO	211	O75962
VDLREYVDICWVDAE	ZFYVE16	1376	Q7Z3T8