Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	carboxylic acid transmembrane transport	LRP2 SLC7A5 SLC7A5P1 ITGB1 SLC7A5P2	2.74e-05	163	45	5	GO:1905039
GeneOntologyBiologicalProcess	immune response in gut-associated lymphoid tissue	TTLL1 ITGB7	2.78e-05	4	45	2	GO:0002387
GeneOntologyBiologicalProcess	organic acid transmembrane transport	LRP2 SLC7A5 SLC7A5P1 ITGB1 SLC7A5P2	3.08e-05	167	45	5	GO:1903825
GeneOntologyBiologicalProcess	L-alpha-amino acid transmembrane transport	SLC7A5 SLC7A5P1 ITGB1 SLC7A5P2	3.86e-05	87	45	4	GO:1902475
GeneOntologyBiologicalProcess	response to muscle activity	SLC7A5 ITGB1 ABCG8	5.54e-05	34	45	3	GO:0014850
GeneOntologyBiologicalProcess	brain development	LRP2 LAMB1 TTLL1 ABL2 ITGB1 CDK5R2 RAD1 TULP3 LARGE1	8.30e-05	859	45	9	GO:0007420
GeneOntologyBiologicalProcess	L-amino acid transport	SLC7A5 SLC7A5P1 ITGB1 SLC7A5P2	8.98e-05	108	45	4	GO:0015807
GeneOntologyBiologicalProcess	reactive gliosis	ITGB1 LARGE1	9.71e-05	7	45	2	GO:0150103
GeneOntologyBiologicalProcess	neural tube closure	LRP2 ABL2 GRHL3 TULP3	1.07e-04	113	45	4	GO:0001843
GeneOntologyBiologicalProcess	tube closure	LRP2 ABL2 GRHL3 TULP3	1.11e-04	114	45	4	GO:0060606
GeneOntologyBiologicalProcess	basement membrane organization	LAMB1 ITGB1 LARGE1	1.13e-04	43	45	3	GO:0071711
GeneOntologyBiologicalProcess	amino acid transmembrane transport	SLC7A5 SLC7A5P1 ITGB1 SLC7A5P2	1.35e-04	120	45	4	GO:0003333
GeneOntologyBiologicalProcess	primary neural tube formation	LRP2 ABL2 GRHL3 TULP3	1.35e-04	120	45	4	GO:0014020
GeneOntologyBiologicalProcess	head development	LRP2 LAMB1 TTLL1 ABL2 ITGB1 CDK5R2 RAD1 TULP3 LARGE1	1.39e-04	919	45	9	GO:0060322
GeneOntologyBiologicalProcess	embryo development ending in birth or egg hatching	LRP2 TTLL1 ABL2 SF3B1 GRHL3 ITGB1 CNOT2 KIF1B TULP3	1.51e-04	929	45	9	GO:0009792
GeneOntologyBiologicalProcess	integrin-mediated signaling pathway	LAMB1 DST ITGB1 ITGB7	1.53e-04	124	45	4	GO:0007229
GeneOntologyBiologicalProcess	central nervous system development	LRP2 LAMB1 TTLL1 ABL2 GRHL3 ITGB1 CDK5R2 RAD1 TULP3 LARGE1	2.06e-04	1197	45	10	GO:0007417
GeneOntologyBiologicalProcess	neural tube formation	LRP2 ABL2 GRHL3 TULP3	2.06e-04	134	45	4	GO:0001841
GeneOntologyBiologicalProcess	gliogenesis	LRP2 LAMB1 SLC7A5 ABL2 CDK5R2 LARGE1	3.45e-04	435	45	6	GO:0042063
GeneOntologyBiologicalProcess	mucociliary clearance	TTLL1 DNAH9	3.58e-04	13	45	2	GO:0120197
GeneOntologyBiologicalProcess	embryonic epithelial tube formation	LRP2 ABL2 GRHL3 TULP3	3.96e-04	159	45	4	GO:0001838
GeneOntologyBiologicalProcess	neural nucleus development	CDK5R2 RAD1 LARGE1	5.21e-04	72	45	3	GO:0048857
GeneOntologyBiologicalProcess	epithelial tube formation	LRP2 ABL2 GRHL3 TULP3	5.45e-04	173	45	4	GO:0072175
GeneOntologyBiologicalProcess	chordate embryonic development	LRP2 TTLL1 ABL2 SF3B1 GRHL3 ITGB1 CNOT2 TULP3	6.82e-04	906	45	8	GO:0043009
GeneOntologyBiologicalProcess	positive regulation of neural precursor cell proliferation	LRP2 DISP3 ITGB1	7.09e-04	80	45	3	GO:2000179
GeneOntologyBiologicalProcess	tube formation	LRP2 ABL2 GRHL3 TULP3	7.29e-04	187	45	4	GO:0035148
GeneOntologyBiologicalProcess	morphogenesis of embryonic epithelium	LRP2 ABL2 GRHL3 TULP3	7.74e-04	190	45	4	GO:0016331
GeneOntologyCellularComponent	protein kinase CK2 complex	CSNK2A3 CSNK2A1	2.71e-05	4	45	2	GO:0005956
GeneOntologyCellularComponent	hemidesmosome	DST ITGB1	2.46e-04	11	45	2	GO:0030056
GeneOntologyCellularComponent	protein complex involved in cell adhesion	LAMB1 ITGB1 ITGB7	2.79e-04	59	45	3	GO:0098636
GeneOntologyCellularComponent	cytoplasmic region	DST DNAH9 PCLO KIF1B TULP3	1.02e-03	360	45	5	GO:0099568
GeneOntologyCellularComponent	neuromuscular junction	ITGB1 PCLO LARGE1	1.80e-03	112	45	3	GO:0031594
GeneOntologyCellularComponent	growth cone	LRP2 CDK5R2 PCLO FRMD7	1.88e-03	245	45	4	GO:0030426
GeneOntologyCellularComponent	site of polarized growth	LRP2 CDK5R2 PCLO FRMD7	2.11e-03	253	45	4	GO:0030427
GeneOntologyCellularComponent	integrin complex	ITGB1 ITGB7	2.16e-03	32	45	2	GO:0008305
GeneOntologyCellularComponent	basement membrane	LAMB1 DST ITGB1	2.30e-03	122	45	3	GO:0005604
GeneOntologyCellularComponent	vacuolar membrane	LRP2 SLC7A5 ATP6V1B1 LPCAT1 PLEKHM2	4.52e-03	507	45	5	GO:0005774
GeneOntologyCellularComponent	serine/threonine protein kinase complex	CSNK2A3 CDK5R2 CSNK2A1	4.68e-03	157	45	3	GO:1902554
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	DST DNAH9 KIF1B TULP3	4.74e-03	317	45	4	GO:0032838
GeneOntologyCellularComponent	protein kinase complex	CSNK2A3 CDK5R2 CSNK2A1	5.84e-03	170	45	3	GO:1902911
GeneOntologyCellularComponent	ATPase dependent transmembrane transport complex	ATP6V1B1 ABCG8	6.26e-03	55	45	2	GO:0098533
MousePheno	abnormal brain size	CHSY1 DST ITGB1 SPIN4 CSNK2A1 KIF1B TULP3	3.32e-05	375	35	7	MP:0000771
MousePheno	spina bifida cystica	GRHL3 TULP3	6.06e-05	5	35	2	MP:0012547
Domain	Integrin_bsu_cyt_dom	ITGB1 ITGB7	7.72e-05	6	43	2	IPR014836
Domain	Integrin_b_cyt	ITGB1 ITGB7	7.72e-05	6	43	2	SM01241
Domain	Integrin_b_cyt	ITGB1 ITGB7	7.72e-05	6	43	2	PF08725
Domain	Integrin_bsu_tail	ITGB1 ITGB7	1.08e-04	7	43	2	IPR012896
Domain	Integrin_B_tail	ITGB1 ITGB7	1.08e-04	7	43	2	SM01242
Domain	Integrin_B_tail	ITGB1 ITGB7	1.08e-04	7	43	2	PF07965
Domain	INB	ITGB1 ITGB7	1.44e-04	8	43	2	SM00187
Domain	Integrin_beta	ITGB1 ITGB7	1.44e-04	8	43	2	PF00362
Domain	Integrin_bsu_VWA	ITGB1 ITGB7	1.44e-04	8	43	2	IPR002369
Domain	Integrin_bsu	ITGB1 ITGB7	1.84e-04	9	43	2	IPR015812
Domain	INTEGRIN_BETA	ITGB1 ITGB7	1.84e-04	9	43	2	PS00243
Domain	PSI_integrin	ITGB1 ITGB7	1.84e-04	9	43	2	PF17205
Domain	Integin_beta_N	ITGB1 ITGB7	1.84e-04	9	43	2	IPR033760
Domain	EGF_extracell	LRP2 ITGB1 ITGB7	3.55e-04	60	43	3	IPR013111
Domain	EGF_2	LRP2 ITGB1 ITGB7	3.55e-04	60	43	3	PF07974
Domain	ATPase_dyneun-rel_AAA	MDN1 DNAH9	4.63e-04	14	43	2	IPR011704
Domain	AAA_5	MDN1 DNAH9	4.63e-04	14	43	2	PF07728
Domain	-	MDN1 ITGB1 ITGB7	6.58e-04	74	43	3	3.40.50.410
Domain	VWFA	MDN1 ITGB1 ITGB7	8.87e-04	82	43	3	PS50234
Domain	VWA	MDN1 ITGB1 ITGB7	9.51e-04	84	43	3	SM00327
Domain	Integrin_dom	ITGB1 ITGB7	1.50e-03	25	43	2	IPR032695
Domain	VWF_A	MDN1 ITGB1 ITGB7	1.53e-03	99	43	3	IPR002035
Domain	EGF_1	LRP2 LAMB1 ITGB1 ITGB7	2.76e-03	255	43	4	PS00022
Domain	EGF-like_CS	LRP2 LAMB1 ITGB1 ITGB7	3.00e-03	261	43	4	IPR013032
Domain	PSI	ITGB1 ITGB7	4.61e-03	44	43	2	IPR016201
Domain	PSI	ITGB1 ITGB7	5.03e-03	46	43	2	SM00423
Domain	EF-hand_1	LPCAT1 DST RYR3	5.14e-03	152	43	3	PF00036
Domain	Kinase-like_dom	ABL2 DST CSNK2A3 CSNK2A1 SGK3	7.83e-03	542	43	5	IPR011009
Domain	Protein_kinase_ATP_BS	ABL2 CSNK2A3 CSNK2A1 SGK3	1.10e-02	379	43	4	IPR017441
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	HSD17B12 NUP188 CSNK2A3 CSNK2A1 RYR3 STOML2 DUT	1.91e-08	231	45	7	36597993
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	HSD17B12 LAMB1 SLC7A5 BCKDHA NUP188 MDN1 DST SF3B1 LMBRD2 ITGB1 STOML2 PSMB2 DUT	2.11e-08	1440	45	13	30833792
Pubmed	Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1.	SLC7A5 SLC7A5P1 SLC7A5P2	7.06e-08	7	45	3	12009310
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	HSD17B12 LAMB1 SLC7A5 LPCAT1 NUP188 SF3B1 ITGB1 STOML2 PSMB2	1.40e-07	657	45	9	36180527
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	HSD17B12 LPCAT1 NUP188 SF3B1 ITGB1 STOML2 PSMB2	8.98e-07	408	45	7	33766124
Pubmed	β1 integrin is critical for the maintenance of antigen-specific CD4 T cells in the bone marrow but not long-term immunological memory.	ITGB1 ITGB7	1.64e-06	2	45	2	21357540
Pubmed	β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation.	ABL2 ITGB1	1.64e-06	2	45	2	23552693
Pubmed	Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.	CSNK2A3 CSNK2A1	1.64e-06	2	45	2	14646071
Pubmed	Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase.	ABL2 ITGB1	1.64e-06	2	45	2	25694433
Pubmed	Assignment of casein kinase 2 alpha sequences to two different human chromosomes.	CSNK2A3 CSNK2A1	1.64e-06	2	45	2	1577469
Pubmed	Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.	CSNK2A3 CSNK2A1	1.64e-06	2	45	2	12860116
Pubmed	Adult murine hematopoiesis can proceed without beta1 and beta7 integrins.	ITGB1 ITGB7	1.64e-06	2	45	2	16735603
Pubmed	Molecular cloning of the human casein kinase II alpha subunit.	CSNK2A3 CSNK2A1	1.64e-06	2	45	2	2752008
Pubmed	Structure and sequence of an intronless gene for human casein kinase II-alpha subunit.	CSNK2A3 CSNK2A1	1.64e-06	2	45	2	8420794
Pubmed	Defining the membrane proteome of NK cells.	CHSY1 SLC7A5 LPCAT1 NUP188 MDN1 LMBRD2 ITGB1 ITGB7 CNOT2 PSMB2	1.92e-06	1168	45	10	19946888
Pubmed	Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.	CSNK2A3 CSNK2A1	4.91e-06	3	45	2	15684395
Pubmed	The pathophysiologic role of alpha 4 integrins in vivo.	ITGB1 ITGB7	4.91e-06	3	45	2	7525645
Pubmed	Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis.	LAMB1 ITGB1	4.91e-06	3	45	2	8951069
Pubmed	Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.	CSNK2A3 CSNK2A1	4.91e-06	3	45	2	2174700
Pubmed	Structure of three tandem filamin domains reveals auto-inhibition of ligand binding.	ITGB1 ITGB7	4.91e-06	3	45	2	17690686
Pubmed	Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit.	CSNK2A3 CSNK2A1	4.91e-06	3	45	2	1766873
Pubmed	Integrin α4β1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection.	ITGB1 ITGB7	4.91e-06	3	45	2	24659687
Pubmed	Dendritic cell immunization route determines integrin expression and lymphoid and nonlymphoid tissue distribution of CD8 T cells.	ITGB1 ITGB7	4.91e-06	3	45	2	17237400
Pubmed	Immunohistochemical localization of extracellular matrix proteins in developing lung tissues.	LAMB1 ITGB1	4.91e-06	3	45	2	17334455
Pubmed	Expression of murine beta 7, alpha 4, and beta 1 integrin genes by rodent mast cells.	ITGB1 ITGB7	4.91e-06	3	45	2	1381390
Pubmed	Crystallization and preliminary characterization of crystals of human protein kinase CK2.	CSNK2A3 CSNK2A1	4.91e-06	3	45	2	11092945
Pubmed	Control of alpha4beta7 integrin expression and CD4 T cell homing by the beta1 integrin subunit.	ITGB1 ITGB7	4.91e-06	3	45	2	20118278
Pubmed	Dominant Suppression of β1 Integrin by Ectopic CD98-ICD Inhibits Hepatocellular Carcinoma Progression.	SLC7A5 ITGB1	4.91e-06	3	45	2	27834933
Pubmed	Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylation.	ITGB1 ITGB7	4.91e-06	3	45	2	15225631
Pubmed	TMEM182 interacts with integrin beta 1 and regulates myoblast differentiation and muscle regeneration.	LAMB1 ITGB1	4.91e-06	3	45	2	34427057
Pubmed	Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.	CSNK2A3 CSNK2A1	4.91e-06	3	45	2	12102635
Pubmed	Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.	CSNK2A3 CSNK2A1	4.91e-06	3	45	2	20625391
Pubmed	A family of beta 7 integrins on human mucosal lymphocytes.	ITGB1 ITGB7	9.81e-06	4	45	2	1542691
Pubmed	Similar but nonidentical amino acid residues on vascular cell adhesion molecule-1 are involved in the interaction with alpha 4 beta 1 and alpha 4 beta 7 under different activity states.	ITGB1 ITGB7	9.81e-06	4	45	2	7594538
Pubmed	The alpha 1 beta 1 and alpha E beta 7 integrins define a subset of dendritic cells in peripheral lymph nodes with unique adhesive and antigen uptake properties.	ITGB1 ITGB7	9.81e-06	4	45	2	14688336
Pubmed	Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior.	ABL2 ITGB1	9.81e-06	4	45	2	22357865
Pubmed	Biologically-active laminin-111 fragment that modulates the epithelial-to-mesenchymal transition in embryonic stem cells.	LAMB1 ITGB1	9.81e-06	4	45	2	24706882
Pubmed	β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments.	ITGB1 ITGB7	9.81e-06	4	45	2	23708002
Pubmed	Reduced immunohistochemical expression of adhesion molecules in vitiligo skin biopsies.	LAMB1 ITGB1	9.81e-06	4	45	2	28214208
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	HSD17B12 SLC7A5 NUP188 MDN1 SF3B1 CSNK2A1 PCLO STOML2 PSMB2 DUT	1.11e-05	1425	45	10	30948266
Pubmed	ADAM2 interactions with mouse eggs and cell lines expressing α4/α9 (ITGA4/ITGA9) integrins: implications for integrin-based adhesion and fertilization.	ITGB1 ITGB7	1.63e-05	5	45	2	21060781
Pubmed	Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.	ITGB1 ITGB7	1.63e-05	5	45	2	19843520
Pubmed	Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality.	LAMB1 ITGB1	1.63e-05	5	45	2	7544312
Pubmed	Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development.	ABL2 GRHL3 RAD1	1.65e-05	38	45	3	29799838
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	LRP2 THUMPD1 HSD17B12 BCKDHA NUP188 MDN1 DST ITGB1 PCLO STOML2	1.69e-05	1496	45	10	32877691
Pubmed	Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.	HSD17B12 BCKDHA LPCAT1 TMEM87A STOML2 DUT	2.07e-05	438	45	6	32628020
Pubmed	Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins.	ITGB1 ITGB7	2.45e-05	6	45	2	14681217
Pubmed	Integrins as receptors for laminins.	LAMB1 ITGB1	2.45e-05	6	45	2	11054877
Pubmed	Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.	ITGB1 ITGB7	2.45e-05	6	45	2	19346499
Pubmed	Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth.	LAMB1 ITGB1	2.45e-05	6	45	2	19118221
Pubmed	Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations.	ITGB1 ITGB7	2.45e-05	6	45	2	24829201
Pubmed	Rapid leukocyte migration by integrin-independent flowing and squeezing.	ITGB1 ITGB7	2.45e-05	6	45	2	18451854
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	LAMB1 DST SF3B1 CSNK2A1 RYR3	3.28e-05	284	45	5	29459677
Pubmed	The primitive endoderm segregates from the epiblast in β1 integrin-deficient early mouse embryos.	LRP2 ITGB1	3.42e-05	7	45	2	24277939
Pubmed	A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.	CSNK2A3 CSNK2A1	3.42e-05	7	45	2	11239457
Pubmed	Differential expression of laminin chain-specific mRNA transcripts during mouse preimplantation embryo development.	LAMB1 ITGB1	3.42e-05	7	45	2	8722691
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	HSD17B12 SLC7A5 NUP188 MDN1 ITGB1 STOML2	3.62e-05	484	45	6	31995728
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	HSD17B12 SLC7A5 BCKDHA NUP188 MDN1 SF3B1 STOML2	3.79e-05	725	45	7	27025967
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	LAMB1 SPIN4 CSNK2A1 PCLO PSMB2 LARGE1	4.15e-05	496	45	6	31343991
Pubmed	Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.	CSNK2A1 RAD1	4.56e-05	8	45	2	20545769
Pubmed	p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.	CSNK2A3 CSNK2A1	4.56e-05	8	45	2	12393879
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	LAMB1 PCLO RYR3 LARGE1	7.18e-05	171	45	4	20201926
Pubmed	Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo.	LAMB1 ITGB1	7.32e-05	10	45	2	16554364
Pubmed	Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro.	LAMB1 ITGB1	7.32e-05	10	45	2	18590826
Pubmed	Integrin-Mediated Focal Anchorage Drives Epithelial Zippering during Mouse Neural Tube Closure.	GRHL3 ITGB1	7.32e-05	10	45	2	32049039
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	THUMPD1 LPCAT1 MDN1 SF3B1 KIF1B STOML2 DUT	7.55e-05	809	45	7	32129710
Pubmed	The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.	DST ITGB1	8.94e-05	11	45	2	10811835
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	HSD17B12 BCKDHA LPCAT1 SF3B1 ITGB1 KIF1B	9.20e-05	573	45	6	28330616
Pubmed	Alpha9 and beta8 integrin expression correlates with the merger of the developing mouse eyelids.	ITGB1 ITGB7	1.07e-04	12	45	2	10090148
Pubmed	Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.	ITGB1 ITGB7	1.07e-04	12	45	2	12606711
Pubmed	Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system.	ITGB1 SGK3	1.07e-04	12	45	2	24687281
Pubmed	CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow.	ITGB1 ITGB7	1.27e-04	13	45	2	18308860
Pubmed	Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.	LAMB1 ITGB1	1.47e-04	14	45	2	19783738
Pubmed	Laminin alpha5 chain is required for intestinal smooth muscle development.	LAMB1 ITGB1	1.70e-04	15	45	2	12921739
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	HSD17B12 LPCAT1 MDN1 ITGB1 STOML2 PSMB2	1.78e-04	647	45	6	26618866
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	HSD17B12 SLC7A5 BCKDHA NUP188 MDN1 SF3B1 STOML2 PSMB2	1.87e-04	1257	45	8	37317656
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NUP188 MDN1 DST SF3B1 CSNK2A1 STOML2	1.87e-04	653	45	6	22586326
Pubmed	Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling.	LAMB1 ITGB1	1.94e-04	16	45	2	17601529
Pubmed	Integrin requirement for hippocampal synaptic plasticity and spatial memory.	ITGB1 ITGB7	1.94e-04	16	45	2	12904471
Pubmed	Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling.	LAMB1 ITGB1	1.94e-04	16	45	2	35132078
Pubmed	Beta1-integrins are critical for cerebellar granule cell precursor proliferation.	LAMB1 ITGB1	2.20e-04	17	45	2	15056720
Pubmed	Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus.	LAMB1 ITGB1	2.20e-04	17	45	2	18082680
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	HSD17B12 LAMB1 NUP188 DST SF3B1 ITGB1 CSNK2A1 RAD1	2.31e-04	1297	45	8	33545068
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	DST SF3B1 KIF1B	2.35e-04	92	45	3	15840729
Pubmed	TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts.	LAMB1 ITGB1	2.47e-04	18	45	2	23041440
Pubmed	Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis.	LRP2 ATP6V1B1	2.76e-04	19	45	2	16177003
Pubmed	Generation of Distal Renal Segments Involves a Unique Population of Aqp2 + Progenitor Cells.	LRP2 ATP6V1B1	2.76e-04	19	45	2	34667084
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	HSD17B12 SLC7A5 NUP188 SF3B1 CSNK2A1 STOML2 PSMB2 DUT	2.81e-04	1335	45	8	29229926
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	NUP188 MDN1 SF3B1 ITGB1 CSNK2A1 PSMB2	2.87e-04	707	45	6	19738201
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	LRP2 ITGB1 ITGB7	3.09e-04	101	45	3	23382219
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	NUP188 MDN1 DST SF3B1 ITGB1 CSNK2A1 STOML2	3.21e-04	1024	45	7	24711643
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	THUMPD1 SLC7A5 LPCAT1 SF3B1 ITGB1 KIF1B STOML2 PSMB2	3.29e-04	1367	45	8	32687490
Pubmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.	SLC7A5 LPCAT1 ITGB1 TMEM87A TULP3	3.35e-04	467	45	5	30194290
Pubmed	The Wilms tumor gene, Wt1, maintains testicular cord integrity by regulating the expression of Col4a1 and Col4a2.	LAMB1 ITGB1	3.38e-04	21	45	2	23325811
Pubmed	SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.	MDN1 CSNK2A1	3.38e-04	21	45	2	37014752
Pubmed	Schwann cell myelination requires integration of laminin activities.	LAMB1 ITGB1	3.38e-04	21	45	2	22767514
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	PCLO KIF1B LARGE1	3.46e-04	105	45	3	9628581
Pubmed	Blood-Brain Barrier: From Physiology to Disease and Back.	LRP2 SLC7A5 ITGB1	3.46e-04	105	45	3	30280653
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	LRP2 NUP188 MDN1 DST CDK5R2 PCLO	3.55e-04	736	45	6	29676528
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	HSD17B12 BCKDHA ITGB1 CSNK2A1 STOML2 TULP3 PSMB2	3.71e-04	1049	45	7	27880917
Interaction	OBSL1 interactions	LAMB1 NUP188 MDN1 DST SF3B1 SPIN4 CSNK2A1 PCLO STOML2 TULP3 PSMB2	2.68e-06	902	44	11	int:OBSL1
Cytoband	5p13.2	LMBRD2 RAD1	4.29e-04	31	45	2	5p13.2
GeneFamily	CD molecules\|Integrin beta subunits	ITGB1 ITGB7	7.68e-05	9	27	2	1159
GeneFamily	EF-hand domain containing	LPCAT1 DST RYR3	4.14e-03	219	27	3	863
Coexpression	BENPORATH_NANOG_TARGETS	LRP2 HSD17B12 SLC7A5 BCKDHA SF3B1 SLC7A5P1 ITGB1 TMEM87A SLC7A5P2 RYR3 SGK3 LARGE1	7.02e-08	988	45	12	M6616
Coexpression	MITSIADES_RESPONSE_TO_APLIDIN_DN	LPCAT1 NUP188 MDN1 SF3B1 CSNK2A1 DUT	4.23e-06	250	45	6	M11318
Coexpression	GSE32423_CTRL_VS_IL7_IL4_MEMORY_CD8_TCELL_UP	THUMPD1 CHSY1 ITGB1 ITGB7 DUT	2.35e-05	200	45	5	M5087
Coexpression	BENPORATH_SOX2_TARGETS	LRP2 HSD17B12 SLC7A5 BCKDHA SLC7A5P1 SLC7A5P2 SGK3 LARGE1	3.14e-05	734	45	8	M3835
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 DISP3 DNAH9 PCLO RYR3	1.16e-06	184	45	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 DISP3 DNAH9 PCLO RYR3	1.16e-06	184	45	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 DISP3 DNAH9 PCLO RYR3	1.16e-06	184	45	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	DISP3 MDN1 DST KIF1B	2.10e-05	161	45	4	347edb0de10850b7d16c40945751033289289c9b
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 DNAH9 PCLO RYR3	2.54e-05	169	45	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 DNAH9 PCLO RYR3	2.78e-05	173	45	4	66f37c1437705734b20601656fa4aa1d92ca30be
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 DNAH9 PCLO RYR3	2.78e-05	173	45	4	649b08a409095592cccf31883be69c754411280d
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A5 DST ITGB1 TMEM87A	2.91e-05	175	45	4	1ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DISP3 GRHL3 CDK5R2 PCLO	3.18e-05	179	45	4	f2e8fc975c30992611630197b79daaeef7c4211d
ToppCell	10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-basophil\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SLC7A5 LMBRD2 ITGB7 RYR3	4.35e-05	194	45	4	5da8873cddff582e5693b32fd3aaebc102f65fc0
ToppCell	368C-Myeloid-Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SLC7A5 RBKS LPCAT1 ABL2	4.35e-05	194	45	4	f9b9cbd1a418a7cbd151c2425fda6b864db9aa82
ToppCell	368C-Myeloid-Monocyte-CD14+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SLC7A5 RBKS LPCAT1 ABL2	4.44e-05	195	45	4	8da933942e9033e18e25ab47831c269747b1c0b2
ToppCell	facs-Trachea-3m\|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DST SF3B1 ITGB1 CSNK2A1	4.62e-05	197	45	4	e77016d64b1cac9825fec7cfe5071f1567401187
ToppCell	facs-Trachea-nan-3m\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST SF3B1 ITGB1 CSNK2A1	4.62e-05	197	45	4	0353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCell	distal-3-Hematologic-Natural_Killer_T\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLC7A5 ITGB1 ITGB7 SLC7A5P2	4.71e-05	198	45	4	b5da18f2a3554dca36e88be3b96a89089c2f2e1d
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	HSD17B12 ATP6V1B1 DST PCLO	4.80e-05	199	45	4	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	(01)_IL1RL1+\|World / shred by cell type by condition	LAMB1 SLC7A5 DST ITGB1	4.89e-05	200	45	4	501420901bf3ec1b050e0d14596a9f9f3fdfc928
Disease	hepatocellular carcinoma (is_implicated_in)	SLC7A5 SF3B1 RYR3 KIF1B	1.53e-04	181	44	4	DOID:684 (is_implicated_in)
Disease	cancer (implicated_via_orthology)	DST ITGB1 ITGB7 DUT	6.79e-04	268	44	4	DOID:162 (implicated_via_orthology)
Disease	urate measurement, bone density	HSD17B12 ATP6V1B1 TTLL1 DNAH9 CSNK2A1	2.21e-03	619	44	5	EFO_0003923, EFO_0004531

Protein segments in the cluster

Peptide	Gene	Start	Entry
FMFLYYPPLDIDISY	DISP3	91	Q9P2K9
TEYMPYGNLLDYLRE	ABL2	361	P42684
SVMELDSYPLYAIYL	ABCG8	631	Q9H221
LYLAYSYMGNEISYP	CDK5R2	266	Q13319
CYQGYGYPLMLFLEE	RAD1	111	O60671
YPIDLYYLMDLSYSM	ITGB1	141	P05556
AFYLAYYPNLSLEDM	RBKS	276	Q9H477
EMYPAFAEEYLYPDQ	LPCAT1	481	Q8NF37
LSDIDFLPMYGLYEY	LARGE1	561	O95461
SYMEEFPFPYYIILR	MDN1	5556	Q9NU22
FLTRPGDYDELGYMF	MSS51	276	Q4VC12
MAGYLSPAAYLYVEE	DST	1	Q03001
PYGEKIYMTLSAYLE	KIF1B	1376	O60333
DYYALYGKEIRSPMA	FRMD7	661	Q6ZUT3
LYGGMLIEDYIYESL	PCLO	1946	Q9Y6V0
DYAYMLDVYGSLPAF	SLC7A5P1	116	Q8MH63
DYAYMLEVYGSLPAF	SLC7A5	116	Q01650
YLEFFIDNIPYSMEY	LAMB1	596	P07942
DYAYMLDVYGSLPAF	SLC7A5P2	116	Q9GIP4
DYPNRLLYFMDSYLD	LRP2	1606	P98164
YDLYSAYDYTIPPME	DUT	136	P33316
RAEGYPVDLYYLMDL	ITGB7	146	P26010
YFKGPELLVDYQMYD	CSNK2A3	196	Q8NEV1
SVAALSFLYDYYMGP	GRHL3	56	Q8TE85
MSYEYPEYFLDVPDL	HSD17B12	136	Q53GQ0
YFKGPELLVDYQMYD	CSNK2A1	196	P68400
PYDDLRYLFGEIMYG	DNAH9	4101	Q9NYC9
LYEMLYGLPPFYCRD	SGK3	351	Q96BR1
YRDYPLELFMAQCYG	BCKDHA	166	P12694
MPDYYKPQYLLDFED	PLEKHM2	166	Q8IWE5
GFPGYMYTDLATIYE	ATP6V1B1	316	P15313
VLSFIADGFYIYYPM	LMBRD2	521	Q68DH5
EGPALYYMDYLAALA	PSMB2	111	P49721
IEDLSGYMEYYLYIP	OSER1	266	Q9NX31
PMYGAEYILDLLLLY	CHSY1	441	Q86X52
EDLLFYLYYMNGGDV	CNOT2	441	Q9NZN8
DLYAFYPMLIRYVDN	RYR3	3261	Q15413
GYLIPLMDAEYANYY	SF3B1	751	O75533
YEKDPVLYMYTLLDD	SPIN4	156	Q56A73
VLYMYTLLDDYKDGD	SPIN4	161	Q56A73
EIIFLYYAYFEMAPS	NUP188	216	Q5SRE5
YYAYFEMAPSDLLVL	NUP188	221	Q5SRE5
YLRIMDPYKASYGVE	STOML2	106	Q9UJZ1
GLFPTYYMYLEKEEN	TULP3	216	O75386
AYSLLNEYGDDMYGP	THUMPD1	61	Q9NXG2
YLDFVPVTYMLPADY	TTLL1	106	O95922
YEYLTLEDYPLMIFF	TMEM87A	216	Q8NBN3