Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-7 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-24

4.56e-09371347GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-7 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-24

5.55e-09381347GO:0070001
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8

6.17e-07111344GO:0004523
GeneOntologyMolecularFunctionacetylcholine receptor regulator activity

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

9.05e-07271345GO:0030548
GeneOntologyMolecularFunctionneurotransmitter receptor regulator activity

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

1.10e-06281345GO:0099602
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8

1.84e-06141344GO:0003964
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-7 ERVK-10 ERVK-8

1.06e-05211344GO:0035613
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-10 ERVK-8 DNA2

1.39e-05461345GO:0016893
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNA1A CACNA1B CACNA1E

2.41e-0591343GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNA1A CACNA1B CACNA1E

2.41e-0591343GO:0099626
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1A CACNA1B CACNA1E

1.02e-04141343GO:0008331
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-10 ERVK-8

1.08e-04371344GO:0016891
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8

1.20e-04381344GO:0034061
GeneOntologyMolecularFunctionglycogen phosphorylase activity

PYGB PYGM

1.34e-0431342GO:0008184
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ERVK-6 ERVK-7 ERVK-10 ERVK-8 DNA2 TOP3B DNMT3L CDK7

3.96e-042621348GO:0140097
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

ERVK-6 DIS3L2 POLR2B ERVK-7 ERVK-10 ERVK-8 DDX20 DNA2 TOP3B DDX4 MOV10 DNMT3L CDK7

4.07e-0464513413GO:0140640
GeneOntologyMolecularFunction1,4-alpha-oligoglucan phosphorylase activity

PYGB PYGM

4.41e-0451342GO:0004645
GeneOntologyMolecularFunctionhexosyltransferase activity

UGT1A6 UGGT1 GALNT9 PYGB PYGM UGT2B11 POFUT2

5.63e-042111347GO:0016758
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-6 POLR2B OAS3 ERVK-7 ERVK-10 ERVK-8

5.68e-041521346GO:0016779
GeneOntologyMolecularFunctionprotein kinase binding

IL12RB2 IL31RA COPB2 CEP192 SPDYE18 TRIM64C SPDYE2 FAM83G ZFYVE26 SPDYE5 PLD2 SPDYE2B SPDYE6 MAP3K2 SPDYE16

7.76e-0487313415GO:0019901
GeneOntologyMolecularFunctionhydrolase activity, acting on ester bonds

ERVK-6 PDE6A DIS3L2 ABHD12B ERVK-7 ERVK-10 LCAT INPP5F PTPRU ERVK-8 GPCPD1 PLD2 DNA2 PLCE1

1.07e-0380713414GO:0016788
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

EPHB3 ERVK-6 KALRN POLR2B CDK19 INSRR OAS3 ERVK-7 CHEK1 ERVK-10 MAP3K3 DGKK ERVK-8 MAP3K2 CDK7

1.59e-0393813415GO:0016772
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8

1.97e-03791344GO:0004521
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

ERVK-6 DIS3L2 POLR2B ERVK-7 ERVK-10 ERVK-8 DDX20 DDX4 MOV10

2.04e-034171349GO:0140098
GeneOntologyMolecularFunctionkinase binding

IL12RB2 IL31RA COPB2 CEP192 SPDYE18 TRIM64C SPDYE2 FAM83G ZFYVE26 SPDYE5 PLD2 SPDYE2B SPDYE6 MAP3K2 SPDYE16

2.18e-0396913415GO:0019900
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-6 DIS3L2 ERVK-7 ERVK-10 ERVK-8

2.25e-031361345GO:0004540
GeneOntologyMolecularFunctionendonuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8 DNA2

2.25e-031361345GO:0004519
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-6 USP29 ERVK-7 ERVK-9 ERVK-10 MEP1B ERVK-8 ERVK-19 ERVK-24

2.50e-034301349GO:0004175
GeneOntologyMolecularFunctiontransition metal ion binding

ERVK-6 DPYD MYCBP2 KDM5A KDM4C ERVK-7 ERVK-9 ERVK-10 TRIM64C HEPH MEP1B AHCY ERVK-8 ERVK-19 TADA2A DMD ERVK-24

2.55e-03118913417GO:0046914
GeneOntologyMolecularFunctionzinc ion binding

ERVK-6 MYCBP2 KDM5A KDM4C ERVK-7 ERVK-9 ERVK-10 TRIM64C MEP1B ERVK-8 ERVK-19 TADA2A DMD ERVK-24

2.67e-0389113414GO:0008270
GeneOntologyMolecularFunctionvinculin binding

SYNM DMD

3.32e-03131342GO:0017166
GeneOntologyMolecularFunctionglycosyltransferase activity

UGT1A6 UGGT1 GALNT9 PYGB PYGM UGT2B11 POFUT2

3.34e-032881347GO:0016757
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

4.42e-07251305GO:0045737
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein kinase activity

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

8.05e-07281305GO:1904031
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-7 ERVK-10 ERVK-8

1.03e-06131304GO:0015074
DomainSpy1

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

5.54e-09111255PF11357
DomainSpeedy

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

5.54e-09111255IPR020984
DomainCa_chan_IQ

CACNA1A CACNA1B CACNA1E

1.00e-0571253SM01062
DomainCa_chan_IQ

CACNA1A CACNA1B CACNA1E

1.00e-0571253PF08763
DomainVDCC_a1su_IQ

CACNA1A CACNA1B CACNA1E

1.00e-0571253IPR014873
DomainGPHH

CACNA1A CACNA1B CACNA1E

1.00e-0571253PF16905
DomainGPHH_dom

CACNA1A CACNA1B CACNA1E

1.00e-0571253IPR031649
DomainVDCCAlpha1

CACNA1A CACNA1B CACNA1E

3.39e-05101253IPR002077
DomainFN3

EPHB3 IL12RB2 FLNC IL31RA COL12A1 KALRN INSRR PTPRU

3.49e-051851258SM00060
DomainFilamin

FLNB FLNC MYCBP2

4.64e-05111253PF00630
DomainFILAMIN_REPEAT

FLNB FLNC MYCBP2

4.64e-05111253PS50194
DomainFilamin/ABP280_rpt

FLNB FLNC MYCBP2

4.64e-05111253IPR001298
DomainFilamin/ABP280_repeat-like

FLNB FLNC MYCBP2

4.64e-05111253IPR017868
DomainFN3_dom

EPHB3 IL12RB2 FLNC IL31RA COL12A1 KALRN INSRR PTPRU

8.25e-052091258IPR003961
DomainARM-type_fold

PDS5B RIPOR2 RTTN USP24 CSE1L NF1 PSME4 UPF2 EIF4G1 TNPO3

9.52e-0533912510IPR016024
Domainfn3

EPHB3 IL12RB2 IL31RA COL12A1 KALRN INSRR PTPRU

1.10e-041621257PF00041
DomainPHOSPHORYLASE

PYGB PYGM

1.33e-0431252PS00102
DomainGlycg_phsphrylas

PYGB PYGM

1.33e-0431252IPR011833
DomainGlyco_trans_35

PYGB PYGM

1.33e-0431252IPR000811
DomainPhosphorylase

PYGB PYGM

1.33e-0431252PF00343
Domain-

EPHB3 ILDR2 IL12RB2 FLNB FLNC IL31RA COL12A1 KALRN MYCBP2 INSRR PTPRU FAM187B GPCPD1 IGSF23

1.42e-04663125142.60.40.10
DomainIg-like_fold

EPHB3 ILDR2 IL12RB2 FLNB FLNC IL31RA COL12A1 KALRN MYCBP2 INSRR PTPRU FAM187B GPCPD1 IGSF23

2.72e-0470612514IPR013783
DomainFN3

EPHB3 IL12RB2 IL31RA COL12A1 KALRN INSRR PTPRU

3.88e-041991257PS50853
DomainGalactose-bd-like

EPHB3 MYCBP2 PTPRU MEP1B FBXO44

4.23e-04941255IPR008979
DomainACTININ_2

FLNB FLNC DMD

4.70e-04231253PS00020
DomainACTININ_1

FLNB FLNC DMD

4.70e-04231253PS00019
DomainActinin_actin-bd_CS

FLNB FLNC DMD

4.70e-04231253IPR001589
DomainSEC14

KALRN SEC14L3 NF1

6.04e-04251253SM00516
Domain-

PDS5B RIPOR2 RTTN CSE1L NF1 PSME4 TNPO3

7.43e-0422212571.25.10.10
DomainCRAL_TRIO

KALRN SEC14L3 NF1

7.61e-04271253PS50191
DomainCRAL-TRIO_dom

KALRN SEC14L3 NF1

8.48e-04281253IPR001251
DomainCH

FLNB FLNC SPEF2 DMD

1.46e-03731254PS50021
DomainCH-domain

FLNB FLNC SPEF2 DMD

1.61e-03751254IPR001715
DomainMIF4G

UPF2 EIF4G1

1.93e-03101252SM00543
DomainJmjN

KDM5A KDM4C

1.93e-03101252SM00545
DomainIG_FLMN

FLNB FLNC

1.93e-03101252SM00557
DomainMIF4G

UPF2 EIF4G1

1.93e-03101252PF02854
DomainJmjN

KDM5A KDM4C

1.93e-03101252PF02375
DomainMIF4G-like_typ-3

UPF2 EIF4G1

1.93e-03101252IPR003890
DomainJMJN

KDM5A KDM4C

1.93e-03101252PS51183
DomainJmjN

KDM5A KDM4C

1.93e-03101252IPR003349
DomainARM-like

PDS5B RIPOR2 RTTN CSE1L NF1 PSME4 TNPO3

2.29e-032701257IPR011989
DomainIL6Ra-bind

IL12RB2 IL31RA

2.35e-03111252PF09240
DomainTypeI_recpt_CBD

IL12RB2 IL31RA

2.35e-03111252IPR015321
PathwayREACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

CACNA1A CACNA1B CACNA1E

4.14e-0511913MM14498
PathwayREACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

CACNA1A CACNA1B CACNA1E

4.14e-0511913M26913
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1A CACNA1B CACNA1E

4.14e-0511913M47958
Pubmed

Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

9.80e-119134536272447
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7 ERVK-10 ERVK-24

2.11e-104134410469592
Pubmed

Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

9.89e-1013134515611625
Pubmed

Characterization of a new family of cyclin-dependent kinase activators.

SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16

4.70e-0917134515574121
Pubmed

The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.

CACNA1A CACNA1B CACNA1E

5.59e-083134338996073
Pubmed

Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.

CACNA1A CACNA1B CACNA1E

5.59e-083134324523520
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-7 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-24

8.34e-0894134721542922
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-9 ERVK-8 ERVK-19

1.02e-0712134414557543
Pubmed

Cerebellar granule cell signaling is indispensable for normal motor performance.

CACNA1A CACNA1B CACNA1E

2.23e-074134337141091
Pubmed

Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.

CACNA1A CACNA1B CACNA1E

2.23e-074134332616470
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-10 ERVK-19

2.23e-07413437983737
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

PDS5B FLNB FLNC DIS3L2 MYCBP2 POLR2B COPB2 OAS3 SLC3A2 CSE1L NF1 PELO PSME4 UPF2 WDR11 EIF4G1 AHCY PYGB DDX20 MOV10

2.59e-0713531342029467282
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

SAMD1 MYCBP2 UGGT1 POLR2B COPB2 SPCS2 SLC3A2 CSE1L PELO PSME4 WDR11 EIF4G1 AHCY PYGB DDX20 ALDH3A2 DNA2 GPAT4 WDR48

3.81e-0712571341937317656
Pubmed

Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.

CACNA1A CACNA1B CACNA1E

5.56e-07513438825650
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-7 ERVK-19

5.56e-075134312629516
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1A CACNA1B CACNA1E

5.56e-075134311296258
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1A CACNA1B CACNA1E

5.56e-075134315451373
Pubmed

An action potential initiation mechanism in distal axons for the control of dopamine release.

CACNA1A CACNA1B CACNA1E

1.11e-066134335324301
Pubmed

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.

CACNA1A CACNA1B CACNA1E

1.11e-066134312827191
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-9 ERVK-19

1.11e-066134315063128
Pubmed

Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.

CACNA1A CACNA1B CACNA1E

1.11e-06613439238069
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

PDS5B FLNB FLNC MYCBP2 UGGT1 COPB2 USP24 CSE1L NF1 EIF4G1 PYGB DDX20 MOV10

1.59e-066531341322586326
Pubmed

Rebuilding essential active zone functions within a synapse.

CACNA1A CACNA1B CACNA1E

1.94e-067134335176221
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

DRC7 FLNB FLNC SPCS2 SLC3A2 CHMP7 WDR11 EIF4G1 VPS13A AHCY ALDH3A2 GPAT4

2.22e-065681341237774976
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

PDS5B DENND4A MYCBP2 UGGT1 POLR2B CDK19 COPB2 SLC3A2 PELO UBAC1 EIF4G1 AHCY FAM83G PYGM DDX20 TNPO3 MOV10 MAP3K2

2.31e-0612841341817353931
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

RIPOR2 SYNM ALMS1 RALGPS1 ZFYVE26 DNAH9

3.25e-0610413469205841
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

FLNB FLNC DENND4A COL12A1 KALRN MYCBP2 KDM5A ALMS1 UPF2 PYGM PLCE1

3.85e-064971341123414517
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1A CACNA1B CACNA1E

4.62e-069134316382099
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DENND4A MYCBP2 KDM5A ARHGAP17 CEP192 CHEK1 INPP5F MAP3K3 NF1 ALMS1 EIF4G1 FAM83G TNPO3 MAP3K2

6.43e-068611341436931259
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

PDS5B CACNA1E FLNB FLNC DENND4A PDE6A KDM5A SPEF2 UGGT1 FER1L6 SLC3A2 DGKK EIF4G1 VPS13A DMD POFUT2 TOP3B RBBP9

1.13e-0514421341835575683
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

MYCBP2 UGGT1 POLR2B COPB2 TRIOBP CEP192 PTPRU SLC3A2 CSE1L WDR11 VPS13A DMD ALDH3A2 TOP3B WDR48

1.36e-0510491341527880917
Pubmed

The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation.

MAP3K3 MAP3K2

1.47e-052134221333552
Pubmed

Blocking the R-type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance.

CACNA1B CACNA1E

1.47e-052134215610184
Pubmed

Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.

CACNA1A CACNA1B

1.47e-052134223426690
Pubmed

Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase.

MAP3K3 MAP3K2

1.47e-05213428621389
Pubmed

NF1 mutation drives neuronal activity-dependent initiation of optic glioma.

NLGN3 NF1

1.47e-052134234040258
Pubmed

A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha.

FLNB FLNC

1.47e-05213429694715
Pubmed

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.

CACNA1A CACNA1B

1.47e-052134223376566
Pubmed

CaV 2.1 α1  subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.

CACNA1A CACNA1B

1.47e-052134238155373
Pubmed

MEKK2 mediates aberrant ERK activation in neurofibromatosis type I.

NF1 MAP3K2

1.47e-052134233177525
Pubmed

The Kelch-like protein 1 modulates P/Q-type calcium current density.

CACNA1A KLHL1

1.47e-052134217289272
Pubmed

Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.

CACNA1A CACNA1E

1.47e-052134216381801
Pubmed

N-type calcium current, Cav2.2, is enhanced in small-diameter sensory neurons isolated from Nf1+/- mice.

CACNA1B NF1

1.47e-052134224755485
Pubmed

The limits of promiscuity: isoform-specific dimerization of filamins.

FLNB FLNC

1.47e-052134212525170
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

1.47e-05213429060628
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

1.47e-05213429460924
Pubmed

Effects of ablation of N- and R-type Ca(2+) channels on pain transmission.

CACNA1B CACNA1E

1.47e-052134212074836
Pubmed

Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes.

PYGB PYGM

1.47e-052134225130497
Pubmed

Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.

CACNA1A CACNA1B

1.47e-052134215050706
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

RIPOR2 MYCBP2 USP24 ERVK-10 INPP5F PTPRU HEPH MAP3K3 SLC3A2 FAT1 NF1 RALGPS1 VPS13A FAM83G POFUT2 TOP3B

1.90e-0512151341615146197
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1A CACNA1B CACNA1E

2.46e-0515134320188150
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1A CACNA1B CACNA1E

2.46e-0515134324453333
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FLNC KALRN MYCBP2 RTTN ARHGAP17 CEP192 FAT1 PSME4 RALGPS1 EIF4G1 PYGB ZFYVE26 TOP3B TNPO3 GPAT4

2.49e-0511051341535748872
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

FLNC PDE6A KALRN UGGT1 POLR2B PSME4 FBXO44 DMD

2.50e-05304134832235678
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

FLNC COPB2 INPP5F NF1 PELO WDR11 DDX20 DMD

3.07e-05313134838270169
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

FLNB FLNC BAZ2B UGGT1 POLR2B CSE1L EIF4G1

3.73e-05235134730258100
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

SAMD1 FLNB MYCBP2 KDM5A USP24 CHEK1 INPP5F ALMS1 TADA2A

3.73e-05418134934709266
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-9 ERVK-10 ERVK-24

4.37e-0518134318664271
Pubmed

Evolution of the Cdk-activator Speedy/RINGO in vertebrates.

SPDYE2 SPDYE6

4.41e-053134222763696
Pubmed

Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors.

CACNA1A CACNA1B

4.41e-053134229466725
Pubmed

Identification of CAP as a costameric protein that interacts with filamin C.

FLNC DMD

4.41e-053134217898075
Pubmed

Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.

ERVK-6 ERVK-9

4.41e-05313429971820
Pubmed

Interactions of intermediate filament protein synemin with dystrophin and utrophin.

SYNM DMD

4.41e-053134216777071
Pubmed

Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact.

FLNB FLNC

4.41e-053134212393796
Pubmed

Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels.

CACNA1A CACNA1B

4.41e-053134229208674
Pubmed

Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.

CACNA1A CACNA1B

4.41e-053134226507659
Pubmed

Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.

FLNB FLNC

4.41e-053134211153914
Pubmed

Biomechanical Properties of the Sarcolemma and Costameres of Skeletal Muscle Lacking Desmin.

SYNM DMD

4.41e-053134234489727
Pubmed

Filamins as integrators of cell mechanics and signalling.

FLNB FLNC

4.41e-053134211252955
Pubmed

Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta.

MAP3K3 MAP3K2

4.41e-053134210085062
Pubmed

Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.

CACNA1A CACNA1B

4.41e-053134224394417
Pubmed

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism.

MAP3K3 MAP3K2

4.41e-053134214681216
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-19

4.41e-053134210516026
Pubmed

Effect of disulfidptosis-related genes SLC3A2, SLC7A11 and FLNB polymorphisms on risk of autoimmune thyroiditis in a Chinese population.

FLNB SLC3A2

4.41e-053134238316082
Pubmed

Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3.

MAP3K3 MAP3K2

4.41e-053134214661019
Pubmed

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

KLHL1 BAZ2B NLGN3 PLCE1 WDR48

5.09e-05103134510819331
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

DIS3L2 MYCBP2 WDR11 EIF4G1 DDX20 DNA2 TOP3B GPAT4 MOV10

8.04e-05462134931138677
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

FLNB FLNC SYNM INSRR TRIOBP ARHGAP17 EIF4G1 MAP3K2

8.19e-05360134833111431
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

DPYD DENND4A MYCBP2 CDCP1 FAT1 NF1 EIF4G1 DNAH9

8.35e-05361134826167880
Pubmed

The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.

FLNB FLNC

8.80e-054134211739414
Pubmed

Structural interaction and functional regulation of polycystin-2 by filamin.

FLNB FLNC

8.80e-054134222802962
Pubmed

The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels.

CACNA1A CACNA1B

8.80e-054134225483588
Pubmed

Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.

CACNA1A CACNA1B

8.80e-054134226283199
Pubmed

MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function.

MAP3K3 MAP3K2

8.80e-054134229662197
Pubmed

A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.

CACNA1A CACNA1B

8.80e-054134215728831
Pubmed

Allele-specific demethylation at an imprinted mammalian promoter.

INPP5F DNMT3L

8.80e-054134217942418
Pubmed

MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway.

MAP3K3 MAP3K2

8.80e-054134211073940
Pubmed

MORC1 represses transposable elements in the mouse male germline.

DDX4 DNMT3L

8.80e-054134225503965
Pubmed

Interactions of Rabconnectin-3 with Cav2 calcium channels.

CACNA1A CACNA1B

8.80e-054134231253182
Pubmed

G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.

CACNA1A CACNA1B

8.80e-054134215953418
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

CACNA1A CACNA1B CACNA1E KALRN USP24 NF1 NMT2 DDX20 TOP3B

9.92e-05475134931040226
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

KLHL10 KLHL1 INSRR CHEK1 FBXO9 TADA2A MAP3K2 CDK7

1.03e-04372134822939624
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

FLNB FLNC UGGT1 COPB2 SPCS2 CHEK1 PTPRU SLC3A2 CSE1L PLD2 DMD ALDH3A2 TNPO3

1.05e-049741341328675297
Pubmed

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

DPYD UGT1A6 SLC5A6 UGT2B11

1.26e-0466134419898482
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

FLNB FLNC UGGT1 COPB2 CSE1L ALMS1 EIF4G1 AHCY MOV10

1.33e-04494134926831064
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-7

1.46e-045134211401426
Pubmed

Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity.

FLNB FLNC

1.46e-045134212006559
Pubmed

Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development.

FLNB FLNC

1.46e-045134217360453
Pubmed

PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway.

MAP3K3 MAP3K2

1.46e-045134212912994
Pubmed

Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.

CACNA1A CACNA1B

1.46e-045134216787652
InteractionPPP1R3B interactions

PYGB PYGM TOP3B PLCE1

5.09e-06191254int:PPP1R3B
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE2 SPDYE5 SPDYE2B SPDYE6

2.52e-0712884756
GeneFamilyFibronectin type III domain containing

EPHB3 IL12RB2 IL31RA COL12A1 KALRN INSRR PTPRU

1.30e-05160887555
GeneFamilyGlycogen phosphorylases

PYGB PYGM

7.00e-053882437
GeneFamilyCalcium voltage-gated channel subunits

CACNA1A CACNA1B CACNA1E

2.67e-0426883253
GeneFamilyUPF1 like RNA helicases

DNA2 MOV10

1.25e-03118821169
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

PDS5B FLNB DPYD MYCBP2 KDM5A KDM4C BAZ2B POLR2B CDK19 USP24 INPP5F FAT1 CSE1L PSME4 UPF2 NMT2 VPS13A DMD PLCE1

2.84e-0885612619M4500
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

FLNB DPYD MYCBP2 KDM5A BAZ2B USP24 INPP5F FAT1 UPF2 NMT2 VPS13A

1.62e-0546612611M13522
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 COL12A1 KALRN FAT1 DGKK DMD DNAH9 PLCE1

5.59e-0818412682cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 COL12A1 KALRN FAT1 DGKK DMD DNAH9 PLCE1

5.59e-081841268ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 COL12A1 KALRN FAT1 DGKK DMD DNAH9 PLCE1

5.59e-0818412682b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

CACNA1A KLHL10 WDR64 PDE6A DMD DNAH9

7.09e-06163126619c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellE16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND4A RIPOR2 KALRN MFSD2B UNC13D VPS13A

1.13e-05177126684591e28482ab62a5ef41e61043eb64912766356
ToppCellE16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND4A RIPOR2 KALRN MFSD2B UNC13D VPS13A

1.13e-0517712664bc100062891d07cacd10ffba38966cc6302c92f
ToppCellE16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND4A RIPOR2 KALRN MFSD2B UNC13D VPS13A

1.13e-0517712669f3a2adb9cd4f0a059afc87b6e377a9702154bb1
ToppCell343B-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ZNF787 SPEF2 CEP192 PTPRU PSME4 MAP3K2

1.46e-0518512661b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCell343B-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ZNF787 SPEF2 CEP192 PTPRU PSME4 MAP3K2

1.46e-05185126602cbf492bc40abebaa93a3a208888afae72fbe06
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CACNA1B CACNA1E KLHL1 MYCBP2 USP29 PTPRU

1.60e-051881266b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons|GW26 / Sample Type, Dataset, Time_group, and Cell type.

CACNA1B CACNA1E RIPOR2 KALRN MYCBP2 NMT2

2.26e-052001266bad32a95b759fad509401b07bc96a56687c2a592
DrugAC1L2VU3

CACNA1A CACNA1B CACNA1E SYNM

4.14e-07121254CID000129572
DrugAC 110

CACNA1A CACNA1B CACNA1E

6.44e-0741253CID000022860
Drugpentasulfane

CACNA1A CACNA1B CACNA1E SYNM

1.50e-06161254CID000448216
DrugAC1LCUXJ

AHCY PYGB PYGM

1.60e-0651253CID000656425
DrugAC1O3M08

DPYD PYGB PYGM

1.60e-0651253CID006331955
DrugEdUMP

DPYD PYGB PYGM

3.19e-0661253CID003085112
Drug5'-deoxy-5'-chloroformycin

AHCY PYGB PYGM

3.19e-0661253CID000126430
Drug3,4-dihydroquinazoline

CACNA1A CACNA1B CACNA1E

3.19e-0661253CID000583065
Drugalpha-sialylcholesterol

CACNA1A CACNA1B CACNA1E

3.19e-0661253CID000133976
DrugAC1L3372

DPYD PYGB PYGM

5.56e-0671253CID000108025
DrugAPMPA

CACNA1A CACNA1B CACNA1E

5.56e-0671253CID000512300
Drugeuropium

POLR2B CDCP1 HEPH MAP3K3 ALMS1 MAP3K2

8.52e-06871256CID000023981
DrugThiamine hydrochloride [67-03-8]; Down 200; 11.8uM; MCF7; HT_HG-U133A

DENND4A KDM5A CDK19 CSE1L NF1 ALMS1 PLD2 WDR48

1.21e-0519412587479_DN
DrugPyrilamine maleate [59-33-6]; Down 200; 10uM; MCF7; HT_HG-U133A

DENND4A KDM5A BAZ2B NF1 TADA2A DNA2 MAP3K2 WDR48

1.21e-0519412583184_DN
Drug5'-methylthiotubercidin

AHCY PYGB PYGM

1.32e-0591253CID000188350
Drugeniluracil

CACNA1A CACNA1B CACNA1E DPYD

1.38e-05271254CID000043157
Drug2,6-dihydroxypyridine

DPYD PYGB PYGM

1.88e-05101253CID000069371
Drugleys

CACNA1A CACNA1B CACNA1E

2.58e-05111253CID000484683
Druggastrodin

CACNA1B PDS5B CACNA1E

2.58e-05111253CID000115067
Drugaristolactam AII

CACNA1B CACNA1E

2.99e-0521252CID000148657
Drugalkosin

CACNA1B CACNA1E

2.99e-0521252CID005488638
Drugnorcepharadione B

CACNA1B CACNA1E

2.99e-0521252CID000189168
Drugpiperolactam A

CACNA1B CACNA1E

2.99e-0521252CID003081016
Drugphenylurethane

SYNM PYGB PYGM

3.43e-05121253CID000007591
Drugpapaverine

CACNA1A CACNA1B CACNA1E PDE6A PLD2 DDX4 PLCE1

5.42e-051761257CID000004680
DrugL-BVAU

DPYD AHCY PYGB PYGM

5.53e-05381254CID000667554
DrugAC1Q69H9

DPYD PYGB PYGM

5.63e-05141253CID000001814
Drugbutamben

CACNA1A CACNA1B CACNA1E

7.00e-05151253CID000002482
Drugarabinosyladenine

CACNA1A CACNA1B CACNA1E POLR2B OAS3 NLRP14 NF1 UPF2 AHCY PYGB PYGM TADA2A PLD2 DDX4

7.77e-0576212514CID000000191
Drug5-methylthioribose-1-phosphate

AHCY PYGB PYGM

8.59e-05161253CID000000465
Drugfoscarnet

CACNA1A CACNA1B ERVK-6 CACNA1E COL12A1 POLR2B PSME4

8.78e-051901257CID000003414
Drug3,5-dimethylphenyl isocyanate

PYGB PYGM

8.94e-0531252CID000521488
Drug5'-deoxy-5'-fluoro-5'-(methylthio)adenosine

PYGB PYGM

8.94e-0531252CID000147839
DrugNSC758405

PYGB PYGM

8.94e-0531252CID000003201
Drug3,5-dinitrophenyl phosphate

PYGB PYGM

8.94e-0531252CID000151920
Drugpyridoxal phosphoglucose

PYGB PYGM

8.94e-0531252CID000196007
Drug5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone

PYGB PYGM

8.94e-0531252CID000093111
Drugadenosine-5'-chloromethylphosphonate

PYGB PYGM

8.94e-0531252CID000191554
Drughydan

PYGB PYGM

8.94e-0531252CID000008360
DrugEHMF

PYGB PYGM

8.94e-0531252CID000033931
Drugpyridoxal 5'-methylenephosphonate

PYGB PYGM

8.94e-0531252CID003082249
DrugPlp 5'-mpa

PYGB PYGM

8.94e-0531252CID003082151
Drugglucose-1,2-cyclic phosphate

PYGB PYGM

8.94e-0531252CID000191723
Drug3'-FFdUrd

PYGB PYGM

8.94e-0531252CID000072260
Drug2',3',4',5,5'-pentachloro-2-biphenylol

PYGB PYGM

8.94e-0531252CID000119518
DrugAC1L8XK3

PYGB PYGM

8.94e-0531252CID000409735
DrugN-acetyl-N'-beta-D-glucopyranosyl urea

PYGB PYGM

8.94e-0531252CID000446801
Drugriboflavin tetraacetate

PYGB PYGM

8.94e-0531252CID000094186
Drug2,5-dimethyl-3-furanone

PYGB PYGM

8.94e-0531252CID000085730
Drug3,5-dinitrophenol

PYGB PYGM

8.94e-0531252CID000011459
DrugSanguinarine [2447-54-3]; Down 200; 12uM; MCF7; HT_HG-U133A

FLNB CDK19 PTPRU ALMS1 NMT2 ZFYVE26 MAP3K2

9.07e-0519112574168_DN
Drughomonojirimycin

PYGB PYGM DMD

1.04e-04171253CID000159496
Drugfagomine

PYGB PYGM DMD

1.04e-04171253CID000072259
DrugTetramisole hydrochloride [16595-80-5]; Down 200; 16.6uM; MCF7; HT_HG-U133A

EPHB3 CDK19 TRIOBP MAP3K3 ALMS1 VPS13A TOP3B

1.10e-0419712572849_DN
DrugDiprophylline [479-18-5]; Down 200; 15.8uM; MCF7; HT_HG-U133A

KDM4C CDK19 TRIOBP NF1 FBXO9 ZFYVE26 ALDH3A2

1.10e-0419712575482_DN
DrugIvermectin [70288-86-7]; Down 200; 4.6uM; MCF7; HT_HG-U133A

EPHB3 PTPRU CHMP7 CSE1L RALGPS1 PLD2 WDR48

1.10e-0419712577206_DN
Drugmeprobamate

FLNB PTPRU MEP1B PYGB PYGM

1.25e-04881255CID000004064
Drughexachlorophene

CACNA1A CACNA1B CACNA1E UGGT1 SLC5A6

1.39e-04901255CID000003598
Drugpranidipine

CACNA1A CACNA1B CACNA1E

1.47e-04191253CID006436048
DrugN6-Me-dAdo

CACNA1A CACNA1B CACNA1E

1.47e-04191253CID000168948
Drugarabinosyluracil

ERVK-6 DPYD UGT1A6 NF1 UPF2 AHCY PYGB PYGM UGT2B11

1.51e-043541259CID000001177
DrugDantrolene-13C3

CACNA1A CACNA1B CACNA1E PYGB PYGM DMD

1.51e-041451256CID000002951
DrugDAPs

CACNA1A CACNA1B CACNA1E EIF4G1 DMD

1.55e-04921255CID000146339
Drugacyclonucleoside

AHCY PYGB PYGM

1.72e-04201253CID000466144
DrugNSC633770

DPYD PYGB PYGM WDR48

1.77e-04511254CID000003183
Drugtrifluorothymidine

SYNM AHCY PYGB PYGM

1.77e-04511254CID000006256
Druggalocitabine

PYGB PYGM

1.78e-0441252CID000065950
Drug5-deoxyribose-1-phosphate

PYGB PYGM

1.78e-0441252CID000135786
Drugingliforib

PYGB PYGM

1.78e-0441252CID006451325
Druguric acid riboside

PYGB PYGM

1.78e-0441252CID000164933
Drugpseudo-dl-glucose

PYGB PYGM

1.78e-0441252CID000125259
Drugpyridoxal diphosphate

PYGB PYGM

1.78e-0441252CID000125696
Drug2,5-anhydro-D-mannitol 1-phosphate

PYGB PYGM

1.78e-0441252CID000189134
DrugAC1LAMW2

PYGB PYGM

1.78e-0441252CID000491364
DrugFdUrd-C8

PYGB PYGM

1.78e-0441252CID000094262
DrugMem-CC

PYGB PYGM

1.78e-0441252CID003081269
DrugBCIp4A

PYGB PYGM

1.78e-0441252CID000192417
Drug3'-chloromethotrexate

PYGB PYGM

1.78e-0441252CID000097703
DrugADP beta S

CACNA1B CACNA1E PLD2 DDX4 PLCE1

1.89e-04961255CID005310996
DrugAC1L8YNX

AHCY PYGB PYGM

2.64e-04231253CID000410238
Drugalpha-conotoxin SI

CACNA1A CACNA1B CACNA1E

2.64e-04231253CID000163979
DrugLY320135

CACNA1A CACNA1B CACNA1E

2.64e-04231253CID005311257
Drugheptulose-2-P

PYGB PYGM

2.96e-0451252CID000124823
Drug6-FPLP

PYGB PYGM

2.96e-0451252CID000146246
Druggluconohydroximo-1,5-lactone

PYGB PYGM

2.96e-0451252CID009576855
DrugDHPBU

PYGB PYGM

2.96e-0451252CID000125914
Drugalmagel

CACNA1B CACNA1E

2.96e-0451252CID003080942
Drug5'-isobutylthioinosine

PYGB PYGM

2.96e-0451252CID003080910
DrugS 8510

CACNA1A CACNA1B

2.96e-0451252CID005488383
Drugindirubin-5-sulphonate

PYGB PYGM

2.96e-0451252CID005288641
Drug6-amino-5-bromouracil

PYGB PYGM

2.96e-0451252CID000080578
Drugetafenone

PYGB PYGM

2.96e-0451252CID000003275
DrugddEtUrd

PYGB PYGM

2.96e-0451252CID000451452
Drug5-trifluoromethyl-2'-deoxycytidine

PYGB PYGM

2.96e-0451252CID000125618
Drugm-anisidine

PYGB PYGM

2.96e-0451252CID000010824
Drug2-hydroxypropylphosphonate

PYGB PYGM

2.96e-0451252CID000441028
Drug6-FDPL

PYGB PYGM

2.96e-0451252CID000129578
Drug3'-O-methylpyridoxal 5'-phosphate

PYGB PYGM

2.96e-0451252CID003082179
DrugGlcMan

PYGB PYGM

2.96e-0451252CID000152120
DrugU66985

PYGB PYGM

2.96e-0451252CID000127224
Diseasefamilial hemiplegic migraine 1 (implicated_via_orthology)

CACNA1A CACNA1B CACNA1E

6.56e-0831203DOID:0111181 (implicated_via_orthology)
Diseasemigraine (implicated_via_orthology)

CACNA1A CACNA1B CACNA1E

2.62e-0741203DOID:6364 (implicated_via_orthology)
Diseasehereditary ataxia (implicated_via_orthology)

CACNA1A CACNA1B CACNA1E

2.27e-0671203DOID:0050951 (implicated_via_orthology)
Diseasemyofibrillar myopathy 5 (implicated_via_orthology)

FLNB FLNC

4.91e-0531202DOID:0080096 (implicated_via_orthology)
Diseasedistal muscular dystrophy 4 (implicated_via_orthology)

FLNB FLNC

4.91e-0531202DOID:0111190 (implicated_via_orthology)
Diseasestomach carcinoma (is_marker_for)

KDM5A KDM4C SLC3A2

1.25e-04241203DOID:5517 (is_marker_for)
DiseaseColorectal Carcinoma

FLNC DPYD KALRN PTPRU ITPRID1 FAT1 CSE1L NF1 EIF4G1 VPS13A DMD

1.42e-0470212011C0009402
DiseaseHOMA-IR

SPEF2 COPB2 PTPRU

3.27e-04331203EFO_0004501
DiseaseDevelopmental regression

CACNA1B SLC5A6

3.40e-0471202C1836830
Diseasecerebellar ataxia (implicated_via_orthology)

CACNA1A VPS13A

4.52e-0481202DOID:0050753 (implicated_via_orthology)
DiseaseParkinson's disease (implicated_via_orthology)

INSRR SPCS2 FBXO9 EIF4G1 VPS13A

4.66e-041571205DOID:14330 (implicated_via_orthology)
Diseasesystemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus

IL12RB2 FLNB TNPO3

4.99e-04381203EFO_0000685, EFO_0000717, EFO_0000783, MONDO_0007915
DiseaseIntellectual Disability

CACNA1B CACNA1E KDM5A RTTN MFSD2A NF1 SLC5A6 ALDH3A2

4.99e-044471208C3714756
Diseasecognitive function measurement, self reported educational attainment

CACNA1E DPYD DENND4A MYCBP2 TRIOBP CSE1L ALMS1

6.40e-043551207EFO_0004784, EFO_0008354
Diseaseautistic disorder (is_implicated_in)

KDM4C NLGN3 NF1

6.71e-04421203DOID:12849 (is_implicated_in)
Diseaseresponse to carboplatin, response to antineoplastic agent

FLNB SPEF2

7.23e-04101202GO_0097327, GO_0097328
Diseasealopecia areata (is_marker_for)

KDM5A KDM4C

7.23e-04101202DOID:986 (is_marker_for)
Diseasebiliary liver cirrhosis

IL12RB2 SPEF2 TNPO3

7.69e-04441203EFO_0004267
Diseasesleep disorder (implicated_via_orthology)

INSRR NF1

8.81e-04111202DOID:535 (implicated_via_orthology)
DiseaseDEAFNESS, AUTOSOMAL RECESSIVE (disorder)

TRIOBP TMEM132E

1.24e-03131202C1846647
Diseaseoptic cup area measurement

FLNB TRIOBP PLCE1

1.55e-03561203EFO_0006940
Diseasesystemic lupus erythematosus, COVID-19

IL12RB2 OAS3 SEC14L3

1.72e-03581203MONDO_0007915, MONDO_0100096
Diseasemacrophage inflammatory protein 1b measurement

CDCP1 TMEM132E TADA2A TOP3B

2.35e-031361204EFO_0008219
Diseasephosphatidylcholine 36:4 measurement

RIPOR2 UGT2B11

2.40e-03181202EFO_0010382
DiseaseAutosomal Recessive Primary Microcephaly

COPB2 MFSD2A

3.59e-03221202C3711387
Diseaseglaucoma

RIPOR2 KALRN TRIOBP PLCE1

3.67e-031541204MONDO_0005041

Protein segments in the cluster

PeptideGeneStartEntry
EWPPFEYMILATIIA

CACNA1A

96

O00555
DWEDIRKMPEYPTLQ

CDK19

266

Q9BWU1
WEAEINPHMSSYVPI

DDX4

6

Q9NQI0
IDWPPFEYMILATII

CACNA1E

86

Q15878
MAVPFVEDWDLVQTL

CHEK1

1

O14757
ESENPLEMFETVPVW

DNMT3L

171

Q9UJW3
PEGFPEDELMTWQFV

CDCP1

241

Q9H5V8
VDLHPTEPWMLASLY

COPB2

21

P35606
METHEDAWPFLLPVN

BAZ2B

2076

Q9UIF8
PVDAIVLEAPFTNMW

ABHD12B

236

Q7Z5M8
PFDEKMDPWLSELVE

ALMS1

2671

Q8TCU4
MDPWLSELVEPAFVP

ALMS1

2676

Q8TCU4
GEIDFMLENLPEWVT

ALDH3A2

66

P51648
LPEVDPETMQTSEAW

DPYD

461

Q12882
VVNLDVPLDWETYMH

DDX20

381

Q9UHI6
METPVTLINFWPVDS

DMD

3406

P11532
SVLVDWMIPDIPTDI

ANO2

921

Q9NQ90
LTLVWEPEDMEQEPA

DIS3L2

816

Q8IYB7
ITEWPPFEYMILATI

CACNA1B

91

Q00975
VTEALVSMIFPFHWP

DENND4A

431

Q7Z401
LWVPDEEVSPETMVK

PDS5B

811

Q9NTI5
WMVQLPDDPEHPDIF

RALGPS1

496

Q5JS13
DPITARESIWLPFME

RBBP9

46

O75884
SDWMPSVPLPDIQEF

FAT1

4386

Q14517
LSEIDWMNPIFVPEE

DGKK

1191

Q5KSL6
PAVVWIDSTLHQPMF

OR52W1

51

Q6IF63
EEWVVPYIEMDSPIL

LDOC1

101

O95751
PVMDEEEVAHWFLPR

NMT2

366

O60551
MIEWFPDVDSEPTTL

IL31RA

356

Q8NI17
WQLLPMPHAEYEVTR

ITPRID1

541

Q6ZRS4
MYIIPPQDWLDRGDE

GALNT9

301

Q9HCQ5
TPEEEPTGMLDVWYM

IL12RB2

316

Q99665
PWVTEEAYVPVSDMN

FLNB

1726

O75369
KEFFDVWPVLMGEVP

PDE6A

286

P16499
YWEELMDTTRPDIEV

FBXO44

146

Q9H4M3
WATEEPVVPVEPMES

FLNC

1766

Q14315
TYLWEMTSGVEEIPP

KALRN

1306

O60229
VVEMLTEKPPWAEFE

MAP3K2

551

Q9Y2U5
VLMEPDDWPYVVNIT

KDM4C

846

Q9H3R0
SPFWMENPYVKVDTI

EPHB3

146

P54753
LLLPWSMLPDVVDDF

MFSD2B

386

A6NFX1
PVHMVPTELVEKEFW

KDM5A

381

P29375
FTPLEDMIFLKWEEP

PTPRU

496

Q92729
AFLLPWSMLPDVIDD

MFSD2A

411

Q8NA29
HTAVPEVMLPVWFTA

NLGN3

111

Q9NZ94
DTEAWQFPVTLEPMP

ERVK-10

276

P87889
DTEAWQFPVTLEPMP

ERVK-19

276

Q9YNA8
DTEAWQFPVTLEPMP

ERVK-24

276

P63145
DTEAWQFPVTLEPMP

ERVK-6

276

Q7LDI9
DTEAWQFPVTLEPMP

ERVK-7

276

P63130
DTEAWQFPVTLEPMP

ERVK-8

276

P62685
DTEAWQFPVTLEPMP

ERVK-9

276

P63126
DTEAWQFPVTLELMP

HERVK_113

276

P62684
SVILQWVVTMDPEPV

IGSF23

66

A1L1A6
PDRWTEYSIQTMEPD

GPCPD1

211

Q9NPB8
YEPETNQWTLIAPMH

KLHL10

406

Q6JEL2
DVTHSTMNVFWEPVP

COL12A1

1576

Q99715
WYLPPMTREADEDAV

GPAT4

386

Q86UL3
MPDIIWVFPPQAEAE

FBXO9

1

Q9UK97
FETLGTPTEEQWPDM

CDK7

226

P50613
PPEWEEDEERMSFLF

CHMP7

21

Q8WUX9
PLVLLMEWPEATNFA

FRMPD3

466

Q5JV73
YPVLPHVQKSEEMWI

CCDC144B

266

Q3MJ40
APVMLWDESSFPDIP

SLC3A2

486

P08195
FDMPHSWVEQIEISP

DRC7

411

Q8IY82
AEDMEIDIPHVWLYL

EIF4G1

1326

Q04637
MYVPDEWEVPREQIS

INSRR

966

P14616
QDPEFLMIWVLFHSP

CEP192

1586

Q8TEP8
MAWPEDHVFISTPSF

LCAT

281

P04180
RYIEEPLEEAMPCWL

FAM187B

166

Q17R55
PWSKLVPQFEFDPEM

DNAH9

2431

Q9NYC9
YPVLPHVQKSEEMWI

CCDC144A

266

A2RUR9
VKPMDIEESIWSPRF

DNA2

256

P51530
PSDPVEWTVMDVVEY

SAMD1

456

Q6SPF0
VMAQIELWTHPDKYP

AHCY

366

P23526
MDIDHILDWQPPEVI

SEC14L3

66

Q9UDX4
EIGTPDVDFWIIPMI

INPP5F

221

Q9Y2H2
WPHTIPYVLEDSLEM

MEP1B

71

Q16820
TVVEMLTEKPPWAEY

MAP3K3

556

Q99759
VVLVIEDSWLHNPMY

OR5T3

76

Q8NGG3
VFSDQPWLEIPPFVM

OR2B2

16

Q9GZK3
VWTKDHPFPIDIDYM

UPF2

961

Q9HAU5
VDLEDWMDVSLVPAF

OAS3

136

Q9Y6K5
LQEPEAPEVMFELLW

FAM180B

41

Q6P0A1
NMFEYLPTWVEPDPE

FAM83G

406

A6ND36
DPVWHEQVIFKEMFP

FER1L6

301

Q2WGJ9
EPQHTIPDVFIWMLS

FER1L6

711

Q2WGJ9
EWFNFPSVPMKEEVL

RTTN

51

Q86VV8
EWVYVNEPVPEEMPL

SPEF2

1011

Q9C093
EEMPLFLVPYWELIE

SPEF2

1021

Q9C093
YDVLNAPLEMTVWVP

TMEM132E

521

Q6IEE7
PEIVIWAEHVENMPS

SYNM

321

O15061
YEIMTSDFPVLDPSW

TADA2A

61

O75478
LPEMVRFEPTWEELE

POFUT2

346

Q9Y2G5
RHYDLESVPMTWDPV

MOV10

356

Q9HCE1
PEEEIMQILSSWFPE

PLCE1

2086

Q9P212
LPEPLMTFNLYEEWT

ARHGAP17

331

Q68EM7
TVTMEDLIRPWFPEF

SLC5A6

376

Q9Y289
FPATFVTAEMVPWEP

HEPH

326

Q9BQS7
SQPSPILEFLEEWSM

POLR2B

536

P30876
FPECVRWMTIEFDPQ

MYCBP2

2041

O75592
VTLVPEEPEDMWHTY

PELO

16

Q9BRX2
LAPEPEETWVVEMLC

SPDYE2B

86

A6NHP3
EEEAPSWDELAVMIP

TRIOBP

161

Q9H2D6
LEITWYPFDVEDMTA

RIPOR2

311

Q9Y4F9
DTEAWQFPVTLEPMP

ERVK-9

276

P63128
EPFSLWVFPQEMVLE

CLUHP3

61

Q96NS8
GFTEVMPWQSVPLEE

TOP3B

451

O95985
EDFPQKWPDLLTEMV

CSE1L

121

P55060
NEMFGVWEPLLEPLE

VPS13A

1776

Q96RL7
LEYWPRTHVNPMDEE

WDR48

471

Q8TAF3
WVDTQVVLAMPYDTP

PYGM

216

P11217
EVEELDNWQPAVPLM

SPATS1

271

Q496A3
LPSFAVEIMPEWVFV

ILDR2

176

Q71H61
IVALIWDYMHPFPES

SPCS2

96

Q15005
LAPEPEETWVVEMLC

SPDYE16

46

A6NNV3
LAPEPEETWVVEMLC

SPDYE18

86

P0DV79
LAPEPEETWVVEMLC

SPDYE2

86

Q495Y8
LAPEPEETWVVEMLC

SPDYE5

86

A6NIY4
LAPEPEETWVVEMLC

SPDYE6

86

P0CI01
WLDTQVVLAMPYDTP

PYGB

216

P11216
QGVPWEYIPFEALIM

USP29

316

Q9HBJ7
PEEVFMAIRNPLEWH

NF1

2356

P21359
PLDRAVFWIEFVMPH

UGT2B11

456

O75310
ADLELPWRPLYDMVE

PSME4

136

Q14997
NPPWEVTEAVLFIMA

TNPO3

431

Q9Y5L0
EEPFMPAWEVVTSAI

ZNF773

71

Q6PK81
TMLEDEITWLDNFEP

USP24

1536

Q9UPU5
LAPEPEETWVVEMLC

nan

46

A6NJR5
VPQAMEWLIEHAEDP

UBAC1

221

Q9BSL1
VEPLDLAVFWVEFVM

UGT1A6

451

P19224
RELWETYHMPDVELL

TRIM64C

231

A6NLI5
RMDEQELTEPVWCPY

WDR11

831

Q9BZH6
FEDFIDRETTPRMPW

PLD2

526

O14939
SGDPIPMLQEDFWIS

ZFYVE26

936

Q68DK2
QLDWPDPEEAFMITV

UNC13D

646

Q70J99
TPESWMVESVRTPYD

UGGT1

1076

Q9NYU2
IYLMVIWELPDVVPF

WDR64

586

B1ANS9
PVDILIMDDDDVPSW

ZNF787

26

Q6DD87
ERYDPKTDTWTMVAP

KLHL1

671

Q9NR64
DWPSTEGPIEEIMYQ

NLRP14

236

Q86W24