Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of nuclear pore

NUP214 NUP58 POM121 POM121C POM121B

9.81e-1025385GO:0017056
GeneOntologyMolecularFunctionnuclear localization sequence binding

NUP214 NUP58 POM121 POM121C POM121B

1.49e-0927385GO:0008139
GeneOntologyMolecularFunctionsignal sequence binding

NUP214 NUP58 POM121 POM121C POM121B

4.19e-0851385GO:0005048
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD1 RGPD2 RGPD8

7.09e-0620383GO:0061665
GeneOntologyMolecularFunctionSUMO transferase activity

RGPD1 RGPD2 RGPD8

4.35e-0536383GO:0019789
GeneOntologyMolecularFunctiondisaccharide binding

LGALS9C LGALS9B

7.36e-057382GO:0048030
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD1 RGPD2 RGPD8

1.17e-0450383GO:0003755
GeneOntologyMolecularFunctiongalactoside binding

LGALS9C LGALS9B

1.26e-049382GO:0016936
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD1 RGPD2 RGPD8

1.39e-0453383GO:0016859
GeneOntologyMolecularFunctionnuclear export signal receptor activity

NUP214 NUP42

2.30e-0412382GO:0005049
GeneOntologyMolecularFunctionpeptide binding

NUP214 NUP58 POM121 POM121C POM121B

3.24e-04318385GO:0042277
GeneOntologyMolecularFunctionoligosaccharide binding

LGALS9C LGALS9B

6.56e-0420382GO:0070492
GeneOntologyMolecularFunctionnucleocytoplasmic carrier activity

NUP214 NUP42

1.69e-0332382GO:0140142
GeneOntologyBiologicalProcessmRNA transport

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

5.78e-12145399GO:0051028
GeneOntologyBiologicalProcessRNA transport

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

3.15e-11175399GO:0050658
GeneOntologyBiologicalProcessnucleic acid transport

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

3.15e-11175399GO:0050657
GeneOntologyBiologicalProcessestablishment of RNA localization

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

3.68e-11178399GO:0051236
GeneOntologyBiologicalProcessRNA localization

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

2.16e-10217399GO:0006403
GeneOntologyBiologicalProcessnucleobase-containing compound transport

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

7.28e-10249399GO:0015931
GeneOntologyBiologicalProcessnuclear export

RGPD1 RGPD2 NUP214 NUP42 POM121 RGPD8 POM121C POM121B

1.75e-09185398GO:0051168
GeneOntologyBiologicalProcessprotein import into nucleus

RGPD1 RGPD2 NUP214 NUP58 POM121 RGPD8 POM121C POM121B

2.65e-09195398GO:0006606
GeneOntologyBiologicalProcessimport into nucleus

RGPD1 RGPD2 NUP214 NUP58 POM121 RGPD8 POM121C POM121B

3.36e-09201398GO:0051170
GeneOntologyBiologicalProcessprotein localization to nucleus

RGPD1 DNAJB6 RGPD2 NUP214 NUP58 POM121 RGPD8 POM121C POM121B

1.91e-08362399GO:0034504
GeneOntologyBiologicalProcessnuclear transport

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

2.77e-08378399GO:0051169
GeneOntologyBiologicalProcessnucleocytoplasmic transport

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

2.77e-08378399GO:0006913
GeneOntologyBiologicalProcessestablishment of protein localization to organelle

RGPD1 LHCGR RGPD2 EPS15 NUP214 NUP58 POM121 RGPD8 POM121C POM121B

2.86e-085153910GO:0072594
GeneOntologyBiologicalProcessprotein localization to organelle

RGPD1 DNAJB6 LHCGR RGPD2 EPS15 NUP214 NUP58 POM121 RGPD8 POM121C POM121B RAB33B

4.67e-0710913912GO:0033365
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD1 RGPD2 RGPD8

5.21e-079393GO:0033133
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD1 RGPD2 RGPD8

7.43e-0710393GO:1903301
GeneOntologyBiologicalProcessintracellular protein transport

RGPD1 LHCGR RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

8.23e-077403910GO:0006886
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD1 RGPD2 RGPD8

1.76e-0613393GO:0033131
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD1 RGPD2 RGPD8

2.24e-0614393GO:1903299
GeneOntologyBiologicalProcessnuclear pore organization

POM121 POM121C POM121B

5.00e-0618393GO:0006999
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD1 RGPD2 RGPD8

6.97e-0620393GO:0006607
GeneOntologyBiologicalProcessintracellular transport

RGPD1 LHCGR RGPD2 EPS15 EPS15L1 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

1.26e-0514963912GO:0046907
GeneOntologyBiologicalProcessnegative regulation of natural killer cell degranulation

LGALS9C LGALS9B

2.09e-054392GO:0043322
GeneOntologyBiologicalProcessRNA export from nucleus

NUP214 POM121 POM121C POM121B

3.20e-0596394GO:0006405
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

RGPD1 RGPD2 RGPD8

5.04e-0538393GO:0000413
GeneOntologyBiologicalProcessnegative regulation of exocytosis

LGALS9C LGALS9B RAB33B

8.39e-0545393GO:0045920
GeneOntologyBiologicalProcessregulation of natural killer cell degranulation

LGALS9C LGALS9B

9.68e-058392GO:0043321
GeneOntologyBiologicalProcesslymphocyte activation involved in immune response

MUC19 LGALS9C KMT2A LGALS9B SLC15A4

1.05e-04251395GO:0002285
GeneOntologyBiologicalProcessregulation of carbohydrate biosynthetic process

RGPD1 LHCGR RGPD2 RGPD8

1.11e-04132394GO:0043255
GeneOntologyBiologicalProcesspeptidyl-proline modification

RGPD1 RGPD2 RGPD8

1.45e-0454393GO:0018208
GeneOntologyBiologicalProcessregulation of gluconeogenesis

RGPD1 RGPD2 RGPD8

3.27e-0471393GO:0006111
GeneOntologyBiologicalProcessnegative regulation of natural killer cell activation

LGALS9C LGALS9B

3.60e-0415392GO:0032815
GeneOntologyBiologicalProcessnegative regulation of CD4-positive, alpha-beta T cell proliferation

LGALS9C LGALS9B

3.60e-0415392GO:2000562
GeneOntologyBiologicalProcessnegative regulation of leukocyte degranulation

LGALS9C LGALS9B

4.65e-0417392GO:0043301
GeneOntologyBiologicalProcessnatural killer cell degranulation

LGALS9C LGALS9B

5.23e-0418392GO:0043320
GeneOntologyBiologicalProcessleukocyte activation involved in immune response

MUC19 LGALS9C KMT2A LGALS9B SLC15A4

5.64e-04361395GO:0002366
GeneOntologyBiologicalProcessnegative regulation of alpha-beta T cell proliferation

LGALS9C LGALS9B

5.84e-0419392GO:0046642
GeneOntologyBiologicalProcesspositive regulation of defense response to bacterium

LGALS9C LGALS9B

5.84e-0419392GO:1900426
GeneOntologyBiologicalProcesscell activation involved in immune response

MUC19 LGALS9C KMT2A LGALS9B SLC15A4

5.93e-04365395GO:0002263
GeneOntologyBiologicalProcessregulation of T cell chemotaxis

LGALS9C LGALS9B

6.48e-0420392GO:0010819
GeneOntologyBiologicalProcessregulation of natural killer cell differentiation

LGALS9C LGALS9B

7.15e-0421392GO:0032823
GeneOntologyBiologicalProcessclathrin coat assembly

EPS15 CLINT1

8.60e-0423392GO:0048268
GeneOntologyBiologicalProcessregulation of carbohydrate metabolic process

RGPD1 LHCGR RGPD2 RGPD8

9.27e-04231394GO:0006109
GeneOntologyBiologicalProcessregulation of defense response to bacterium

LGALS9C LGALS9B

1.10e-0326392GO:1900424
GeneOntologyBiologicalProcessprotein folding

RGPD1 DNAJB6 RGPD2 RGPD8

1.17e-03246394GO:0006457
GeneOntologyBiologicalProcesscarbohydrate biosynthetic process

RGPD1 LHCGR RGPD2 RGPD8

1.19e-03247394GO:0016051
GeneOntologyBiologicalProcessgluconeogenesis

RGPD1 RGPD2 RGPD8

1.20e-03111393GO:0006094
GeneOntologyBiologicalProcessregulation of CD4-positive, alpha-beta T cell proliferation

LGALS9C LGALS9B

1.28e-0328392GO:2000561
GeneOntologyBiologicalProcesshexose biosynthetic process

RGPD1 RGPD2 RGPD8

1.33e-03115393GO:0019319
GeneOntologyBiologicalProcessCD4-positive, alpha-beta T cell proliferation

LGALS9C LGALS9B

1.47e-0330392GO:0035739
GeneOntologyBiologicalProcessmonosaccharide biosynthetic process

RGPD1 RGPD2 RGPD8

1.54e-03121393GO:0046364
GeneOntologyBiologicalProcessregulation of lymphocyte chemotaxis

LGALS9C LGALS9B

1.56e-0331392GO:1901623
GeneOntologyBiologicalProcesspositive regulation of regulatory T cell differentiation

LGALS9C LGALS9B

1.56e-0331392GO:0045591
GeneOntologyBiologicalProcesspositive regulation of interleukin-6 production

LGALS9C NCL LGALS9B

1.58e-03122393GO:0032755
GeneOntologyBiologicalProcessnegative regulation of regulated secretory pathway

LGALS9C LGALS9B

1.67e-0332392GO:1903306
GeneOntologyBiologicalProcessT cell chemotaxis

LGALS9C LGALS9B

1.77e-0333392GO:0010818
GeneOntologyBiologicalProcesspositive regulation of tumor necrosis factor production

LGALS9C NCL LGALS9B

2.02e-03133393GO:0032760
GeneOntologyBiologicalProcessregulation of glucose metabolic process

RGPD1 RGPD2 RGPD8

2.07e-03134393GO:0010906
GeneOntologyBiologicalProcesspositive regulation of tumor necrosis factor superfamily cytokine production

LGALS9C NCL LGALS9B

2.20e-03137393GO:1903557
GeneOntologyBiologicalProcessregulation of T cell differentiation in thymus

LGALS9C LGALS9B

2.23e-0337392GO:0033081
GeneOntologyBiologicalProcessnatural killer cell differentiation

LGALS9C LGALS9B

2.35e-0338392GO:0001779
GeneOntologyBiologicalProcessorganism emergence from protective structure

CMTM3 PEMT

2.47e-0339392GO:0071684
GeneOntologyBiologicalProcesshatching

CMTM3 PEMT

2.47e-0339392GO:0035188
GeneOntologyBiologicalProcessblastocyst hatching

CMTM3 PEMT

2.47e-0339392GO:0001835
GeneOntologyBiologicalProcessnegative regulation of natural killer cell mediated cytotoxicity

LGALS9C LGALS9B

2.60e-0340392GO:0045953
GeneOntologyBiologicalProcessnegative regulation of CD4-positive, alpha-beta T cell activation

LGALS9C LGALS9B

2.60e-0340392GO:2000515
GeneOntologyBiologicalProcesspositive regulation of T cell migration

LGALS9C LGALS9B

2.73e-0341392GO:2000406
GeneOntologyBiologicalProcessnegative regulation of natural killer cell mediated immunity

LGALS9C LGALS9B

2.73e-0341392GO:0002716
GeneOntologyBiologicalProcessnatural killer cell activation involved in immune response

LGALS9C LGALS9B

2.86e-0342392GO:0002323
GeneOntologyBiologicalProcesspositive regulation of macrophage activation

LGALS9C LGALS9B

2.86e-0342392GO:0043032
GeneOntologyBiologicalProcesspositive regulation of SMAD protein signal transduction

LGALS9C LGALS9B

3.00e-0343392GO:0060391
GeneOntologyBiologicalProcessCD4-positive, alpha-beta T cell activation

LGALS9C KMT2A LGALS9B

3.01e-03153393GO:0035710
GeneOntologyBiologicalProcesspositive regulation of oxidoreductase activity

LGALS9C LGALS9B

3.42e-0346392GO:0051353
GeneOntologyBiologicalProcessnegative regulation of leukocyte mediated cytotoxicity

LGALS9C LGALS9B

3.57e-0347392GO:0001911
GeneOntologyBiologicalProcessregulation of T-helper 17 type immune response

LGALS9C LGALS9B

3.57e-0347392GO:2000316
GeneOntologyBiologicalProcesspositive regulation of interleukin-10 production

LGALS9C LGALS9B

3.72e-0348392GO:0032733
GeneOntologyBiologicalProcesspositive regulation of lymphocyte migration

LGALS9C LGALS9B

3.87e-0349392GO:2000403
GeneOntologyBiologicalProcessregulation of regulatory T cell differentiation

LGALS9C LGALS9B

3.87e-0349392GO:0045589
GeneOntologyBiologicalProcessresponse to transforming growth factor beta

LGALS9C KMT2A MXRA5 LGALS9B

3.91e-03343394GO:0071559
GeneOntologyBiologicalProcessnucleus organization

POM121 POM121C POM121B

4.04e-03170393GO:0006997
GeneOntologyCellularComponentnuclear pore

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

1.45e-13101389GO:0005643
GeneOntologyCellularComponentnuclear membrane

RGPD1 RGPD2 CMTM3 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

9.67e-09349389GO:0031965
GeneOntologyCellularComponentnuclear envelope

RGPD1 RGPD2 CMTM3 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

4.23e-085603810GO:0005635
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD1 RGPD2 RGPD8

3.08e-078383GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD1 RGPD2 RGPD8

6.59e-0710383GO:0044614
GeneOntologyCellularComponentannulate lamellae

RGPD1 RGPD2 RGPD8

1.99e-0614383GO:0005642
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD1 RGPD2 RGPD8

4.44e-0618383GO:0044615
GeneOntologyCellularComponentorganelle envelope

RGPD1 RGPD2 CMTM3 NUP214 NUP42 NUP58 POM121 RGPD8 PEMT POM121C POM121B TMEM126B

5.29e-0614353812GO:0031967
GeneOntologyCellularComponentnuclear inclusion body

RGPD1 RGPD2 RGPD8

6.18e-0620383GO:0042405
GeneOntologyCellularComponentSUMO ligase complex

RGPD1 RGPD2 RGPD8

7.21e-0621383GO:0106068
GeneOntologyCellularComponentinclusion body

RGPD1 RGPD2 EPS15 RGPD8

2.12e-0590384GO:0016234
GeneOntologyCellularComponentnuclear protein-containing complex

RGPD1 KMT2A RGPD2 NCL NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

2.24e-0513773811GO:0140513
GeneOntologyCellularComponentclathrin coat

EPS15 EPS15L1 CLINT1

1.44e-0456383GO:0030118
GeneOntologyCellularComponentclathrin coat of coated pit

EPS15 EPS15L1

6.61e-0421382GO:0030132
GeneOntologyCellularComponentmembrane coat

EPS15 EPS15L1 CLINT1

9.40e-04106383GO:0030117
GeneOntologyCellularComponentcoated membrane

EPS15 EPS15L1 CLINT1

9.40e-04106383GO:0048475
GeneOntologyCellularComponentclathrin vesicle coat

EPS15 CLINT1

2.17e-0338382GO:0030125
GeneOntologyCellularComponentendosome

LHCGR EPS15 NCL CLINT1 SLC15A4 SLC2A2 RAB33B

4.57e-031167387GO:0005768
GeneOntologyCellularComponentvesicle coat

EPS15 CLINT1

6.60e-0367382GO:0030120
MousePhenoelevated level of mitotic sister chromatid exchange

RGPD1 RGPD2 RGPD8

5.98e-0616323MP:0003701
MousePhenoabnormal morula morphology

RGPD1 RGPD2 RGPD8

2.73e-0526323MP:0012058
MousePhenodecreased tumor latency

RGPD1 RGPD2 RGPD8

4.24e-0530323MP:0010308
MousePhenofailure of blastocyst formation

RGPD1 RGPD2 RGPD8

4.69e-0531323MP:0012129
MousePhenoabnormal tumor latency

RGPD1 RGPD2 RGPD8

6.21e-0534323MP:0010307
MousePhenoenlarged epididymis

RGPD1 LHCGR RGPD2 RGPD8

7.31e-0599324MP:0004931
MousePhenoembryonic lethality before implantation, complete penetrance

RGPD1 KMT2A RGPD2 NUP214 RGPD8

9.00e-05203325MP:0011094
MousePhenoabnormal blastocyst formation

RGPD1 RGPD2 RGPD8

9.42e-0539323MP:0012128
MousePhenoembryonic lethality before implantation

RGPD1 KMT2A RGPD2 NUP214 RGPD8

2.05e-04242325MP:0006204
MousePhenoaneuploidy

RGPD1 RGPD2 RGPD8

3.58e-0461323MP:0004024
MousePhenodecreased susceptibility to diet-induced obesity

RGPD1 RGPD2 RGPD8 TMEM126B

4.63e-04160324MP:0005659
MousePhenoabnormal epididymis size

RGPD1 LHCGR RGPD2 RGPD8

5.32e-04166324MP:0004926
MousePhenoincreased hepatocellular carcinoma incidence

RGPD1 RGPD2 RGPD8

5.37e-0470323MP:0003331
MousePhenoenhanced humoral immune response

LGALS9C LGALS9B

6.76e-0417322MP:0020155
MousePhenoincreased lung carcinoma incidence

RGPD1 RGPD2 RGPD8

7.38e-0478323MP:0008714
MousePhenodecreased susceptibility to weight gain

RGPD1 RGPD2 RGPD8 TMEM126B

8.15e-04186324MP:0010182
MousePhenoincreased T-helper 1 cell number

LGALS9C LGALS9B

8.47e-0419322MP:0008086
DomainGCC2_Rab_bind

RGPD1 RGPD2 RGPD8

2.29e-077363IPR032023
DomainRab_bind

RGPD1 RGPD2 RGPD8

2.29e-077363PF16704
Domain-

RGPD1 RGPD2 RGPD8

7.82e-07103631.10.220.60
DomainGRIP

RGPD1 RGPD2 RGPD8

1.07e-0611363PF01465
DomainGrip

RGPD1 RGPD2 RGPD8

1.07e-0611363SM00755
DomainRan_BP1

RGPD1 RGPD2 RGPD8

1.43e-0612363PF00638
DomainGRIP_dom

RGPD1 RGPD2 RGPD8

1.43e-0612363IPR000237
DomainGRIP

RGPD1 RGPD2 RGPD8

1.43e-0612363PS50913
DomainRANBD1

RGPD1 RGPD2 RGPD8

1.43e-0612363PS50196
DomainRanBD

RGPD1 RGPD2 RGPD8

1.86e-0613363SM00160
DomainRan_bind_dom

RGPD1 RGPD2 RGPD8

1.86e-0613363IPR000156
DomainDUF4704

NBEAL1 NBEAL2

3.60e-055362PF15787
DomainDUF4704

NBEAL1 NBEAL2

3.60e-055362IPR031570
DomainPH_BEACH

NBEAL1 NBEAL2

5.39e-056362PF14844
DomainPH-BEACH_dom

NBEAL1 NBEAL2

1.00e-048362IPR023362
DomainPH_BEACH

NBEAL1 NBEAL2

1.00e-048362PS51783
Domain-

NBEAL1 NBEAL2

1.00e-0483622.30.29.40
DomainBeach

NBEAL1 NBEAL2

1.29e-049362PF02138
Domain-

NBEAL1 NBEAL2

1.29e-0493621.10.1540.10
DomainBEACH_dom

NBEAL1 NBEAL2

1.29e-049362IPR000409
DomainBeach

NBEAL1 NBEAL2

1.29e-049362SM01026
DomainBEACH

NBEAL1 NBEAL2

1.29e-049362PS50197
DomainPH_dom-like

RGPD1 RGPD2 RGPD8 NBEAL1 NBEAL2 FRMD3

1.48e-04426366IPR011993
DomainEF-hand_4

EPS15 EPS15L1

1.61e-0410362PF12763
DomainEH

EPS15 EPS15L1

1.97e-0411362PS50031
DomainEH

EPS15 EPS15L1

1.97e-0411362SM00027
DomainEH_dom

EPS15 EPS15L1

1.97e-0411362IPR000261
DomainGal-bind_lectin

LGALS9C LGALS9B

3.73e-0415362SM00908
DomainGALECTIN

LGALS9C LGALS9B

3.73e-0415362PS51304
DomainGalectin_CRD

LGALS9C LGALS9B

3.73e-0415362IPR001079
DomainGal-bind_lectin

LGALS9C LGALS9B

3.73e-0415362PF00337
DomainGLECT

LGALS9C LGALS9B

3.73e-0415362SM00276
Domain-

LGALS9C LGALS9B NBEAL1

8.06e-04953632.60.120.200
DomainConA-like_dom

LGALS9C LGALS9B NBEAL1 NBEAL2

8.07e-04219364IPR013320
DomainWD40

WDR90 NUP214 NBEAL1 NBEAL2

1.70e-03268364SM00320
DomainWD40_repeat

WDR90 NUP214 NBEAL1 NBEAL2

1.80e-03272364IPR001680
DomainTPR

RGPD1 RGPD2 RGPD8

1.95e-03129363SM00028
DomainTPR_repeat

RGPD1 RGPD2 RGPD8

2.12e-03133363IPR019734
DomainMFS_dom

SLC15A4 SLC2A2 SLC22A15

2.17e-03134363IPR020846
DomainSugar_tr

SLC2A2 SLC22A15

2.18e-0336362PF00083
DomainMFS_sugar_transport-like

SLC2A2 SLC22A15

2.18e-0336362IPR005828
DomainTPR-contain_dom

RGPD1 RGPD2 RGPD8

2.99e-03150363IPR013026
Domain-

WDR90 NUP214 NBEAL1 NBEAL2

3.73e-033333642.130.10.10
DomainWD40/YVTN_repeat-like_dom

WDR90 NUP214 NBEAL1 NBEAL2

3.81e-03335364IPR015943
DomainTPR

RGPD1 RGPD2 RGPD8

3.90e-03165363PS50005
DomainTPR_REGION

RGPD1 RGPD2 RGPD8

3.90e-03165363PS50293
Domain-

RGPD1 RGPD2 RGPD8 FRMD3

6.56e-033913642.30.29.30
Domain-

RGPD1 RGPD2 RGPD8

7.32e-032073631.25.40.10
DomainRRM_1

RBM14 NCL RBFOX3

7.42e-03208363PF00076
DomainRRM

RBM14 NCL RBFOX3

8.33e-03217363SM00360
DomainRRM_dom

RBM14 NCL RBFOX3

9.42e-03227363IPR000504
DomainRRM

RBM14 NCL RBFOX3

9.76e-03230363PS50102
DomainTPR-like_helical_dom

RGPD1 RGPD2 RGPD8

1.01e-02233363IPR011990
DomainTPR_1

RGPD1 RGPD8

1.30e-0290362PF00515
DomainTPR_1

RGPD1 RGPD8

1.30e-0290362IPR001440
DomainNucleotide-bd_a/b_plait

RBM14 NCL RBFOX3

1.33e-02258363IPR012677
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

8.73e-1740319MM14945
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

1.12e-1641319MM15200
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

1.42e-1642319MM15039
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

1.79e-1643319MM14609
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

RGPD1 DNAJB6 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

2.97e-16733110MM14948
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

4.31e-1647319MM14939
PathwayREACTOME_GENE_SILENCING_BY_RNA

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

6.48e-1649319MM14837
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

7.89e-1650319MM14610
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

9.57e-1651319MM15151
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

1.99e-1555319MM14917
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

3.32e-1558319MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

3.32e-1558319MM14736
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

RGPD1 DNAJB6 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

3.36e-15923110MM14951
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

9.86e-1565319MM15147
PathwayREACTOME_GLUCOSE_METABOLISM

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

8.82e-1482319MM15394
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

1.10e-1384319MM14929
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

1.38e-1386319MM15413
PathwayREACTOME_MITOTIC_PROPHASE

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

1.86e-12114319MM15361
PathwayREACTOME_SUMOYLATION

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

6.64e-11169319MM14919
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

4.37e-09271319MM15406
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

5.30e-09277319MM15414
PathwayREACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN

NUP214 NUP42 NUP58 POM121 POM121C

7.08e-0932315M29579
PathwayREACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS

NUP214 NUP42 NUP58 POM121 POM121C

8.33e-0933315M27016
PathwayREACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN

NUP214 NUP42 NUP58 POM121 POM121C

9.75e-0934315M27041
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

NUP214 NUP42 NUP58 POM121 POM121C

1.14e-0835315M27320
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

NUP214 NUP42 NUP58 POM121 POM121C

1.32e-0836315M26974
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

NUP214 NUP42 NUP58 POM121 POM121C

1.32e-0836315M27245
PathwayREACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS

NUP214 NUP42 NUP58 POM121 POM121C

1.52e-0837315M1029
PathwayREACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS

NUP214 NUP42 NUP58 POM121 POM121C

1.52e-0837315M27038
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

NUP214 NUP42 NUP58 POM121 POM121C

2.00e-0839315M27238
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

DNAJB6 NUP214 NUP42 NUP58 POM121 POM121C

2.11e-0882316M27250
PathwayREACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS

NUP214 NUP42 NUP58 POM121 POM121C

2.60e-0841315M29574
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

NUP214 NUP42 NUP58 POM121 POM121C

3.33e-0843315M26975
PathwayREACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS

NUP214 NUP42 NUP58 POM121 POM121C

3.75e-0844315M109
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

NUP214 NUP42 NUP58 POM121 POM121C

4.72e-0846315M27397
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

NUP214 NUP42 NUP58 POM121 POM121C

5.27e-0847315M27395
PathwayREACTOME_SLC_TRANSPORTER_DISORDERS

NUP214 NUP42 NUP58 POM121 POM121C SLC2A2

6.58e-0899316M27474
PathwayREACTOME_CELLULAR_RESPONSES_TO_STIMULI

RGPD1 DNAJB6 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

7.17e-085053110MM15548
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

DNAJB6 NUP214 NUP42 NUP58 POM121 POM121C

7.41e-08101316M27253
PathwayREACTOME_M_PHASE

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

9.53e-08387319MM15364
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

NUP214 NUP42 NUP58 POM121 POM121C

9.77e-0853315M27212
PathwayREACTOME_SNRNP_ASSEMBLY

NUP214 NUP42 NUP58 POM121 POM121C

1.07e-0754315M29594
PathwayREACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS

NUP214 NUP42 NUP58 POM121 POM121C

1.69e-0759315M27606
PathwayREACTOME_METABOLISM_OF_RNA

RGPD1 RGPD2 NCL NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

4.29e-076123110MM15547
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

NUP214 NUP42 NUP58 POM121 POM121C

4.31e-0771315M27394
PathwayREACTOME_ISG15_ANTIVIRAL_MECHANISM

NUP214 NUP42 NUP58 POM121 POM121C

5.31e-0774315M48006
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

NUP214 NUP42 NUP58 POM121 POM121C

6.48e-0777315M27226
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

NUP214 NUP42 NUP58 POM121 POM121C

1.00e-0684315M725
PathwayREACTOME_GLUCOSE_METABOLISM

NUP214 NUP42 NUP58 POM121 POM121C

1.06e-0685315M1870
PathwayREACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS

NUP214 NUP42 NUP58 POM121 POM121C SLC2A2

2.04e-06177316M27476
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

NUP214 NUP42 NUP58 POM121 POM121C

3.18e-06106315M27458
PathwayREACTOME_CELL_CYCLE

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

3.91e-06603319MM14635
PathwayREACTOME_TRNA_PROCESSING

NUP214 NUP42 NUP58 POM121 POM121C

3.99e-06111315M27684
PathwayREACTOME_HCMV_LATE_EVENTS

NUP214 NUP42 NUP58 POM121 POM121C

4.95e-06116315M29806
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

RBM14 RGPD1 KMT2A RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

6.04e-0610223111MM15436
PathwayREACTOME_SARS_COV_2_ACTIVATES_MODULATES_INNATE_AND_ADAPTIVE_IMMUNE_RESPONSES

NUP214 NUP42 NUP58 POM121 POM121C

7.43e-06126315M45009
PathwayBIOCARTA_RANBP2_PATHWAY

RGPD1 RGPD2 RGPD8

7.68e-0618313MM1549
PathwayREACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS

NUP214 NUP42 NUP58 POM121 POM121C

8.98e-06131315M5283
PathwayREACTOME_MITOTIC_METAPHASE_AND_ANAPHASE

RGPD1 RGPD2 POM121 RGPD8 POM121C POM121B

1.02e-05234316MM14898
PathwayREACTOME_HCMV_EARLY_EVENTS

NUP214 NUP42 NUP58 POM121 POM121C

1.16e-05138315M29805
PathwayREACTOME_GENE_SILENCING_BY_RNA

NUP214 NUP42 NUP58 POM121 POM121C

1.20e-05139315M715
PathwayREACTOME_MITOTIC_PROPHASE

NUP214 NUP42 NUP58 POM121 POM121C

1.33e-05142315M27660
PathwayREACTOME_HIV_LIFE_CYCLE

NUP214 NUP42 NUP58 POM121 POM121C

1.68e-05149315M4076
PathwayREACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES

NUP214 NUP42 NUP58 POM121 POM121C

1.79e-05151315M550
PathwayREACTOME_POSTMITOTIC_NUCLEAR_PORE_COMPLEX_NPC_REFORMATION

POM121 POM121C POM121B

1.89e-0524313MM15658
PathwayREACTOME_INFLUENZA_INFECTION

NUP214 NUP42 NUP58 POM121 POM121C

2.16e-05157315M4669
PathwayREACTOME_HCMV_INFECTION

NUP214 NUP42 NUP58 POM121 POM121C

2.51e-05162315M29804
PathwayKEGG_MEDICUS_REFERENCE_NUCLEAR_EXPORT_OF_MRNA

NUP214 NUP58 POM121

3.76e-0530313M47752
PathwayREACTOME_SUMOYLATION

NUP214 NUP42 NUP58 POM121 POM121C

5.26e-05189315M27214
PathwayREACTOME_SARS_COV_2_HOST_INTERACTIONS

NUP214 NUP42 NUP58 POM121 POM121C

7.56e-05204315M45011
PathwayWP_PRADERWILLI_AND_ANGELMAN_SYNDROME

NUP214 NUP42 NUP58 POM121

9.06e-05109314M39542
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

RGPD1 MUC19 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B RAB33B

1.07e-0413893111MM15307
PathwayREACTOME_HIV_INFECTION

NUP214 NUP42 NUP58 POM121 POM121C

1.36e-04231315M12469
PathwayREACTOME_INTERFERON_SIGNALING

NUP214 NUP42 NUP58 POM121 POM121C

2.95e-04273315M983
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

NUP214 NUP42 NUP58 POM121 POM121C

3.49e-04283315M13087
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

NUP214 NUP42 NUP58 POM121 POM121C

3.78e-04288315M16864
PathwayREACTOME_NUCLEAR_ENVELOPE_NE_REASSEMBLY

POM121 POM121C POM121B

4.38e-0468313MM14921
PathwayREACTOME_SARS_COV_2_INFECTION

NUP214 NUP42 NUP58 POM121 POM121C

4.49e-04299315M41727
PathwayREACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES

RGPD1 RGPD2 RGPD8

1.35e-03100313MM14561
PathwayREACTOME_POSTMITOTIC_NUCLEAR_PORE_COMPLEX_NPC_REFORMATION

NUP58 POM121

1.59e-0327312M29807
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC6A11 SLC15A4 SLC2A2 SLC22A15

1.74e-03238314MM15076
PathwayREACTOME_M_PHASE

NUP214 NUP42 NUP58 POM121 POM121C

1.99e-03417315M27662
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC6A11 SLC15A4 SLC2A2 SLC22A15

2.05e-03249314M5988
PathwayREACTOME_EGFR_DOWNREGULATION

EPS15 EPS15L1

2.09e-0331312MM14705
PathwayREACTOME_EGFR_DOWNREGULATION

EPS15 EPS15L1

2.09e-0331312M16597
PathwayREACTOME_MITOTIC_SPINDLE_CHECKPOINT

RGPD1 RGPD2 RGPD8

2.11e-03117313MM15387
PathwayREACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION

RGPD1 RGPD2 RGPD8

2.79e-03129313MM14894
PathwayREACTOME_SARS_COV_INFECTIONS

NUP214 NUP42 NUP58 POM121 POM121C

3.38e-03471315M39009
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

RGPD1 RGPD2 RGPD8

3.59e-03141313MM15266
PathwayREACTOME_METABOLISM_OF_RNA

NCL NUP214 NUP42 NUP58 POM121 POM121C

4.40e-03724316M16843
PathwayREACTOME_SIGNALING_BY_EGFR

EPS15 EPS15L1

5.16e-0349312MM14695
PathwayREACTOME_SIGNALING_BY_EGFR

EPS15 EPS15L1

6.01e-0353312M27039
PathwayREACTOME_CELL_CYCLE_MITOTIC

NUP214 NUP42 NUP58 POM121 POM121C

7.06e-03561315M5336
PathwayREACTOME_INFECTIOUS_DISEASE

EPS15 NCL NUP214 NUP42 NUP58 POM121 POM121C

7.86e-031081317M27548
PathwayREACTOME_CELLULAR_RESPONSES_TO_STIMULI

DNAJB6 NUP214 NUP42 NUP58 POM121 POM121C

8.39e-03828316M27827
PathwayREACTOME_SEPARATION_OF_SISTER_CHROMATIDS

RGPD1 RGPD2 RGPD8

8.57e-03193313MM14890
PathwayREACTOME_MITOTIC_PROMETAPHASE

RGPD1 RGPD2 RGPD8

9.70e-03202313MM15362
PathwayREACTOME_VIRAL_INFECTION_PATHWAYS

NCL NUP214 NUP42 NUP58 POM121 POM121C

1.16e-02888316M48034
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

RGPD1 RGPD2 NUP214 NUP42 NUP58 POM121 RGPD8 POM121C POM121B

1.65e-193839912791264
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD1 RGPD2 NUP214 POM121 RGPD8 POM121C POM121B

8.06e-181539714697343
Pubmed

POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation.

POM121 POM121C POM121B

1.30e-09339330802453
Pubmed

Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.

POM121 POM121C POM121B

1.30e-09339335507432
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

RBM14 RGPD1 DNAJB6 LGALS9C RGPD2 EPS15L1 NCL CLINT1 RGPD8 LGALS9B

3.90e-09701391030196744
Pubmed

Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes.

POM121 POM121C POM121B

5.21e-09439317900573
Pubmed

The glucose transporter 2 regulates CD8+ T cell function via environment sensing.

LGALS9C LGALS9B SLC2A2

1.30e-08539337884694
Pubmed

Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1.

NUP214 NUP42 NUP58 POM121

1.98e-082639412228227
Pubmed

Integrated structural analysis of the human nuclear pore complex scaffold.

NUP214 NUP42 NUP58 POM121

3.62e-083039424315095
Pubmed

The Structure Inventory of the Nuclear Pore Complex.

NUP214 NUP42 NUP58 POM121

3.62e-083039427016207
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

RGPD1 KMT2A RGPD2 NCL RGPD8

4.43e-088639537253089
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD1 RGPD2 RGPD8

4.55e-08739330944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD1 RGPD2 RGPD8

4.55e-08739338838144
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD1 RGPD2 RGPD8

4.55e-08739321205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD1 RGPD2 RGPD8

4.55e-08739318949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD1 RGPD2 RGPD8

4.55e-08739325187515
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD1 RGPD2 RGPD8

4.55e-0873939037092
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD1 RGPD2 RGPD8

4.55e-08739323536549
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD1 RGPD2 RGPD8

4.55e-0873938603673
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD1 RGPD2 RGPD8

4.55e-0873937559465
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD1 RGPD2 RGPD8

4.55e-08739315710750
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD1 RGPD2 RGPD8

4.55e-08739326632511
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD1 RGPD2 RGPD8

4.55e-08739317372272
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD1 RGPD2 RGPD8

4.55e-08739324403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD1 RGPD2 RGPD8

4.55e-08739323818861
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD1 RGPD2 RGPD8

4.55e-08739338657106
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD1 RGPD2 RGPD8

4.55e-08739311353387
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD1 RGPD2 RGPD8

4.55e-08739312191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD1 RGPD2 RGPD8

4.55e-08739322821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD1 RGPD2 RGPD8

4.55e-08739320682751
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD1 RGPD2 RGPD8

7.27e-08839322262462
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD1 RGPD2 RGPD8

7.27e-08839321670213
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD1 RGPD2 RGPD8

7.27e-08839328745977
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD1 RGPD2 RGPD8

7.27e-08839327412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD1 RGPD2 RGPD8

7.27e-08839321310149
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD1 RGPD2 RGPD8

1.09e-0793939733766
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD1 RGPD2 RGPD8

1.09e-07939328100513
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD1 RGPD2 RGPD8

1.09e-07939318394993
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD1 RGPD2 RGPD8

1.09e-07939328877029
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD1 RGPD2 RGPD8

1.09e-07939311553612
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD1 RGPD2 RGPD8

1.09e-07939317887960
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD1 RGPD2 RGPD8

1.09e-07939310601307
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD1 RGPD2 RGPD8

1.56e-071039327160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD1 RGPD2 RGPD8

1.56e-071039316332688
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD1 RGPD2 RGPD8

1.56e-07103938857542
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD1 RGPD2 RGPD8

1.56e-071039321859863
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD1 RGPD2 RGPD8

2.14e-071139335771867
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD1 RGPD2 RGPD8

2.14e-071139317069463
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD1 RGPD2 RGPD8

2.14e-071139334110283
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD1 RGPD2 RGPD8

3.70e-071339331427429
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

EPS15 WDR90 CLINT1 NUP214 POM121 POM121C TRO

4.60e-0743039735044719
Pubmed

Probing nuclear pore complex architecture with proximity-dependent biotinylation.

NUP214 NUP42 NUP58 POM121

1.72e-067739424927568
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD1 RGPD2 RGPD8

1.98e-062239327717094
Pubmed

Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.

NUP214 NUP42 NUP58

2.95e-062539310601273
Pubmed

Crystal structure of the galectin-9 N-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition.

LGALS9C LGALS9B

3.67e-06339216990264
Pubmed

Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17-IgA Axis.

LGALS9C LGALS9B

3.67e-06339229458010
Pubmed

Structural analysis of the human galectin-9 N-terminal carbohydrate recognition domain reveals unexpected properties that differ from the mouse orthologue.

LGALS9C LGALS9B

3.67e-06339218005988
Pubmed

Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3.

LGALS9C LGALS9B

3.67e-06339223585851
Pubmed

Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice.

LGALS9C LGALS9B

3.67e-06339224477688
Pubmed

Galectin-9 is a high affinity IgE-binding lectin with anti-allergic effect by blocking IgE-antigen complex formation.

LGALS9C LGALS9B

3.67e-06339219776007
Pubmed

A unique role for galectin-9 in angiogenesis and inflammatory arthritis.

LGALS9C LGALS9B

3.67e-06339229433546
Pubmed

Cooperative Interactions of Oligosaccharide and Peptide Moieties of a Glycopeptide Derived from IgE with Galectin-9.

LGALS9C LGALS9B

3.67e-06339226582205
Pubmed

Oncogenic miR-93-5p/Gal-9 axis drives CD8 (+) T-cell inactivation and is a therapeutic target for hepatocellular carcinoma immunotherapy.

LGALS9C LGALS9B

3.67e-06339237105392
Pubmed

Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin.

LGALS9C LGALS9B

3.67e-0633929153289
Pubmed

Galectin-9 regulates follicular helper T cells to inhibit humoral autoimmunity-induced pulmonary fibrosis.

LGALS9C LGALS9B

3.67e-06339233316546
Pubmed

Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice.

LGALS9C LGALS9B

3.67e-06339218974023
Pubmed

Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin.

LGALS9C LGALS9B

3.67e-0633929038233
Pubmed

Cell surface galectin-9 expressing Th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion.

LGALS9C LGALS9B

3.67e-06339223144904
Pubmed

Impaired Gal-9 Dysregulates the PBMC-Induced Th1/Th2 Imbalance in Abortion-Prone Matings.

LGALS9C LGALS9B

3.67e-06339229651447
Pubmed

Galectin-9/Tim-3 pathway mediates dopaminergic neurodegeneration in MPTP-induced mouse model of Parkinson's disease.

LGALS9C LGALS9B

3.67e-06339236479526
Pubmed

Protective effect of Galectin-9 in murine model of lung emphysema: Involvement of neutrophil migration and MMP-9 production.

LGALS9C LGALS9B

3.67e-06339228704475
Pubmed

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins.

EPS15 EPS15L1

3.67e-06339211919637
Pubmed

The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity.

LGALS9C LGALS9B

3.67e-06339221146220
Pubmed

Profiling Lgals9 splice variant expression at the fetal-maternal interface: implications in normal and pathological human pregnancy.

LGALS9C LGALS9B

3.67e-06339223242525
Pubmed

Galectin-9 in allergic airway inflammation and hyper-responsiveness in mice.

LGALS9C LGALS9B

3.67e-06339219851072
Pubmed

The Role of Galectin-9 as Mediator of Atopic Dermatitis: Effect on Keratinocytes.

LGALS9C LGALS9B

3.67e-06339233923930
Pubmed

Alarmin function of galectin-9 in murine respiratory tularemia.

LGALS9C LGALS9B

3.67e-06339225898318
Pubmed

Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells.

LGALS9C LGALS9B

3.67e-06339231937306
Pubmed

Intestinal epithelial cells express galectin-9 in patients with food allergy that plays a critical role in sustaining allergic status in mouse intestine.

LGALS9C LGALS9B

3.67e-06339221426359
Pubmed

Intracellular Galectin-9 Enhances Proximal TCR Signaling and Potentiates Autoimmune Diseases.

LGALS9C LGALS9B

3.67e-06339231969388
Pubmed

Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.

LGALS9C LGALS9B

3.67e-06339223836896
Pubmed

Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis.

LGALS9C LGALS9B

3.67e-06339218282810
Pubmed

Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia.

LGALS9C LGALS9B

3.67e-06339235241678
Pubmed

Sequence and mapping of galectin-5, a beta-galactoside-binding lectin, found in rat erythrocytes.

LGALS9C LGALS9B

3.67e-0633927890611
Pubmed

Differential patterns of expression of Eps15 and Eps15R during mouse embryogenesis.

EPS15 EPS15L1

3.67e-06339210906484
Pubmed

Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner.

LGALS9C LGALS9B

3.67e-06339222341088
Pubmed

Regulation of M1‑type and M2‑type macrophage polarization in RAW264.7 cells by Galectin‑9.

LGALS9C LGALS9B

3.67e-06339228990062
Pubmed

Galectin-9 Is a Novel Regulator of Epithelial Restitution.

LGALS9C LGALS9B

3.67e-06339232380082
Pubmed

Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations.

LGALS9C LGALS9B

3.67e-06339224083426
Pubmed

Galectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts.

LGALS9C LGALS9B

3.67e-06339223667648
Pubmed

Galectin-9 in synergy with NF-κB inhibition restores immune regulatory capability in dendritic cells of subjects with food allergy.

LGALS9C LGALS9B

3.67e-06339237279535
Pubmed

Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices.

LGALS9C LGALS9B

3.67e-06339218579572
Pubmed

The protective function of galectin-9 in liver ischemia and reperfusion injury in mice.

LGALS9C LGALS9B

3.67e-06339225931247
Pubmed

Possible regulatory role of galectin-9 on Ascaris suum-induced eosinophilic lung inflammation in mice.

LGALS9C LGALS9B

3.67e-06339222627368
Pubmed

Regulatory T Cell-Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9.

LGALS9C LGALS9B

3.67e-06339228877989
Pubmed

Galectin-9 is required for endometrial regenerative cells to induce long-term cardiac allograft survival in mice.

LGALS9C LGALS9B

3.67e-06339233153471
Pubmed

Galectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages.

LGALS9C LGALS9B

3.67e-06339219800850
Pubmed

T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses.

LGALS9C LGALS9B

3.67e-06339222052881
Pubmed

Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes.

LGALS9C LGALS9B

3.67e-06339217560833
Pubmed

The effect of Toxoplasma gondii infection on galectin-9 expression in decidual macrophages contributing to dysfunction of decidual NK cells during pregnancy.

LGALS9C LGALS9B

3.67e-06339238987795
InteractionRAN interactions

RGPD1 KMT2A RGPD2 NCL NUP214 NUP42 NUP58 RGPD8

2.36e-06475388int:RAN
InteractionNUP107 interactions

RGPD1 NUP214 NUP42 NUP58 RGPD8 POM121C

3.35e-06221386int:NUP107
InteractionNXF2 interactions

NUP214 NUP42 RGPD8 TRO

6.70e-0665384int:NXF2
InteractionDPPA3 interactions

RGPD1 NUP214 NUP58 POM121C

7.56e-0667384int:DPPA3
InteractionRGPD4 interactions

RGPD1 RGPD2 RGPD8

9.29e-0622383int:RGPD4
InteractionRGPD2 interactions

RGPD1 RGPD2 RGPD8

1.75e-0527383int:RGPD2
InteractionNUP43 interactions

RBM14 MUC19 KMT2A NUP214 NUP42 POM121 RGPD8 POM121C

1.76e-05625388int:NUP43
InteractionNUP155 interactions

RGPD1 NUP214 NUP42 NUP58 POM121 POM121C NBEAL1

2.66e-05477387int:NUP155
InteractionNUP153 interactions

NUP214 NUP42 POM121 RGPD8 POM121C

5.08e-05216385int:NUP153
InteractionKPNB1 interactions

RGPD1 NCL NUP214 NUP42 POM121 RGPD8 POM121C

6.13e-05544387int:KPNB1
InteractionRGPD3 interactions

RGPD1 RGPD2 RGPD8

9.47e-0547383int:RGPD3
InteractionRGPD1 interactions

RGPD1 RGPD2 RGPD8

1.07e-0449383int:RGPD1
InteractionNUP35 interactions

RBM14 NUP214 NUP42 NUP58 POM121 POM121C

1.31e-04424386int:NUP35
InteractionNUP42 interactions

NCL NUP214 NUP42 NUP58

1.74e-04149384int:NUP42
InteractionGLE1 interactions

NUP214 NUP42 NUP58 POM121C

1.79e-04150384int:GLE1
Cytoband7q11.23

POM121 POM121C POM121B

7.91e-05973937q11.23
Cytoband17p11.2

LGALS9C PEMT LGALS9B

3.40e-0415939317p11.2
CytobandEnsembl 112 genes in cytogenetic band chr17p11

LGALS9C PEMT LGALS9B

6.92e-04203393chr17p11
CytobandEnsembl 112 genes in cytogenetic band chr2p11

RGPD1 IGKV6D-41 RGPD2

7.96e-04213393chr2p11
Cytoband2p11.2

RGPD1 RGPD2

1.37e-03643922p11.2
CytobandEnsembl 112 genes in cytogenetic band chr7q11

POM121 POM121C POM121B

1.59e-03271393chr7q11
GeneFamilyNucleoporins

NUP214 NUP58 POM121

2.65e-05323331051
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEAL1 NBEAL2

1.15e-0493321230
GeneFamilyGalectins

LGALS9C LGALS9B

3.34e-0415332629
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD1 RGPD2 RGPD8

1.19e-03115333769
GeneFamilySolute carriers

SLC6A11 SLC15A4 SLC2A2 SLC22A15

5.56e-03395334752
GeneFamilyRNA binding motif containing

RBM14 NCL RBFOX3

6.78e-03213333725
GeneFamilyWD repeat domain containing

WDR90 NBEAL1 NBEAL2

1.19e-02262333362
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP

RGPD1 RGPD2 RGPD8

1.49e-0533383MM477
CoexpressionTABULA_MURIS_SENIS_TRACHEA_GRANULOCYTE_AGEING

RGPD1 RGPD2 RGPD8

3.33e-0543383MM3857
CoexpressionICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_DN

POM121 POM121C POM121B

4.09e-0546383MM1256
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_7DY_NEGATIVE

RBM14 RGPD1 RGPD2 CLINT1 NUP58 RGPD8

5.73e-05474386M40991
Diseasealcohol and nicotine codependence

RGPD1 RGPD2

1.12e-0413362EFO_0004776
DiseaseL2 Acute Lymphoblastic Leukemia

KMT2A NUP214

1.71e-0350362C0023453
DiseaseChildhood Acute Lymphoblastic Leukemia

KMT2A NUP214

1.85e-0352362C0023452
DiseasePrecursor Cell Lymphoblastic Leukemia Lymphoma

KMT2A NUP214

2.53e-0361362C1961102
DiseaseEpstein-Barr virus infection

DNAJB6 SLC22A15

2.96e-0366362EFO_0000769
Diseasebody weight

RGPD1 LHCGR PEMT POM121C NBEAL1 SLC2A2

3.90e-031261366EFO_0004338
Diseaseacute myeloid leukemia (is_implicated_in)

KMT2A NUP214

4.74e-0384362DOID:9119 (is_implicated_in)
Diseaseserum gamma-glutamyl transferase measurement

KMT2A POM121 POM121C NBEAL2 SLC2A2

4.79e-03914365EFO_0004532
Diseasephosphatidylcholine measurement

RBFOX3 PEMT FRMD3

4.98e-03284363EFO_0010226
Diseasetrait in response to apixaban

SLC15A4 TRO

8.70e-03115362OBA_2050328

Protein segments in the cluster

PeptideGeneStartEntry
GSGSFNSAEGFADFS

EPS15L1

731

Q9UBC2
SFFTGSGMGFEAFIT

NBEAL1

621

Q6ZS30
GDTAFPGTGGFSATF

RBM14

171

Q96PK6
ASFSSSGAVSGASGF

RAB33B

11

Q9H082
PFAFGNSSATGSLFG

RGPD8

1556

O14715
GSKGFGFVTFETSSD

RBFOX3

136

A6NFN3
GSGCSTAGFFTVFAS

LHCGR

436

P22888
GFADFGSAAASGSFP

CLINT1

346

Q14677
GSSFFFAGTVVTTIG

KCNK16

96

Q96T55
RFSGSGSGTDFTFTI

IGKV6D-41

81

A0A0C4DH26
SGTRFAVDFQTGFSG

LGALS9C

41

Q6DKI2
SGTRFAVDFQTGFSG

LGALS9B

41

Q3B8N2
AGFSSSGASLDVGFG

MUC19

196

Q7Z5P9
VSSFAVGGMTASFFG

SLC2A2

101

P11168
TSGFSFCQASGFGSS

NUP214

1831

P35658
GAKTFGGFASSSFGE

NUP214

1926

P35658
TAAASAGGFGFGSSS

NUP214

2016

P35658
AGGFGFGSSSNTTSF

NUP214

2021

P35658
TGSSKGFGFVDFNSE

NCL

606

P19338
FSFKTNSGFAAASSG

NUP42

246

O15504
NSGFAAASSGSPAGF

NUP42

251

O15504
FGGSTAVFSFGAATS

POM121C

1036

A8CG34
AVFSFGAATSSGFGA

POM121C

1041

A8CG34
SATTGAFSFGAGQSG

POM121C

1101

A8CG34
AFSFGAGQSGSTATS

POM121C

1106

A8CG34
FGGSTAVFSFGAATS

POM121B

641

A6NF01
AVFSFGAATSSGFGA

POM121B

646

A6NF01
SATTGAFSFGAGQSG

POM121B

706

A6NF01
AFSFGAGQSGSTATS

POM121B

711

A6NF01
SSFFALGFAGTFLGD

PEMT

106

Q9UBM1
FGSSFTFGNSAAPAA

POM121

991

Q96HA1
ASSQPAFGGSTAVFF

POM121

1051

Q96HA1
AFGGSTAVFFGAATS

POM121

1056

Q96HA1
TAVFFGAATSSGFGA

POM121

1061

Q96HA1
AFSFGAGQSGSTATS

POM121

1126

Q96HA1
TGTTTFLGFTAAGFV

FRMD3

231

A2A2Y4
GTGSFFSAFSGFPSF

DNAJB6

136

O75190
FSAFSGFPSFGSGFS

DNAJB6

141

O75190
GFPSFGSGFSSFDTG

DNAJB6

146

O75190
GSGFSSFDTGFTSFG

DNAJB6

151

O75190
SFDTGFTSFGSLGHG

DNAJB6

156

O75190
AQGGSFWSITSFGTF

FSCN3

431

Q9NQT6
VGFASGFSASGTAAS

KMT2A

661

Q03164
FASVFGNESFGGGFA

EPS15

711

P42566
VSAASSFFFSGVFVG

SLC22A15

111

Q8IZD6
LFFFFSGVGSFVGSG

SLC15A4

491

Q8N697
LSAGFGSSSTSGFNF

NUP58

541

Q9BVL2
PFAFGNSSATGSLFG

RGPD1

1541

P0DJD0
ATFGTTAGFSGIFSN

TMEM126B

76

Q8IUX1
AFGNSSATGSLFGFS

RGPD2

1551

P0DJD1
TSSGSGFEAFFTAAG

NBEAL2

636

Q6ZNJ1
DGASKAAGVFGFFAT

CMTM3

126

Q96MX0
TFFCGFSSGAVRSFS

WDR90

756

Q96KV7
VGVVGRSASFAGFSS

RIPOR3

16

Q96MK2
GAFSTSAGFGGALST

TRO

1101

Q12816
NASFGSTLGTSAGFS

TRO

1296

Q12816
NSGTSFVAGFAIFSV

SLC6A11

341

P48066
SGSFHQSSSKFFAGG

MXRA5

1826

Q9NR99