Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inhibitory extracellular ligand-gated monoatomic ion channel activity	GABRB2 GLRA3 GLRA1	2.75e-05	8	160	3	GO:0005237
GeneOntologyBiologicalProcess	positive regulation of AMPA receptor activity	RELN SHANK3 NLGN3	4.36e-06	5	158	3	GO:2000969
GeneOntologyBiologicalProcess	NMDA glutamate receptor clustering	RELN NLGN1 SHANK3	8.67e-06	6	158	3	GO:0097114
GeneOntologyBiologicalProcess	positive regulation of excitatory postsynaptic potential	RELN NLGN1 SHANK3 NLGN3 NETO2	1.88e-05	43	158	5	GO:2000463
GeneOntologyBiologicalProcess	postsynaptic specialization assembly	RELN NLGN1 SHANK3 NLGN3 FGFR1	2.11e-05	44	158	5	GO:0098698
GeneOntologyBiologicalProcess	regulation of AMPA receptor activity	RELN NLGN1 SHANK3 NLGN3	3.70e-05	25	158	4	GO:2000311
GeneOntologyBiologicalProcess	regulation of nervous system process	RELN NLGN1 DICER1 SHANK3 NLGN3 NETO2 GLRA1 QKI	6.25e-05	175	158	8	GO:0031644
GeneOntologyBiologicalProcess	excitatory postsynaptic potential	RELN GLRA3 NLGN1 SHANK3 NLGN3 NETO2 GLRA1	6.51e-05	130	158	7	GO:0060079
GeneOntologyBiologicalProcess	regulation of postsynaptic membrane potential	GABRB2 RELN GLRA3 NLGN1 SHANK3 NLGN3 NETO2 GLRA1	7.61e-05	180	158	8	GO:0060078
GeneOntologyBiologicalProcess	postsynaptic density assembly	RELN NLGN1 SHANK3 FGFR1	1.29e-04	34	158	4	GO:0097107
GeneOntologyBiologicalProcess	chemical synaptic transmission, postsynaptic	RELN GLRA3 NLGN1 SHANK3 NLGN3 NETO2 GLRA1	1.41e-04	147	158	7	GO:0099565
GeneOntologyBiologicalProcess	modulation of excitatory postsynaptic potential	RELN NLGN1 SHANK3 NLGN3 NETO2	1.41e-04	65	158	5	GO:0098815
GeneOntologyBiologicalProcess	regulation of respiratory gaseous exchange by nervous system process	NLGN1 NLGN3 GLRA1	1.51e-04	14	158	3	GO:0002087
GeneOntologyCellularComponent	postsynaptic specialization	GABRB2 INPP4A GLRA3 TSC1 NLGN1 DICER1 SHANK3 PRR12 NLGN3 CELSR3 PTPRF NETO2 GLRA1 SCN8A BSN	7.82e-06	503	160	15	GO:0099572
GeneOntologyCellularComponent	postsynaptic specialization membrane	GABRB2 GLRA3 NLGN1 NLGN3 CELSR3 PTPRF NETO2 GLRA1 SCN8A	2.53e-05	201	160	9	GO:0099634
GeneOntologyCellularComponent	glutamatergic synapse	GABRB2 PRUNE2 VPS18 INPP4A DGKQ NLGN1 DICER1 SHANK3 PPM1H KIFAP3 NLGN3 CELSR3 PIAS3 NETO2 SCN8A FGFR1 BSN SEZ6L	5.63e-05	817	160	18	GO:0098978
GeneOntologyCellularComponent	inhibitory synapse	NLGN1 NLGN3 GLRA1 BSN	8.85e-05	31	160	4	GO:0060077
GeneOntologyCellularComponent	postsynapse	GABRB2 INPP4A GLRA3 DGKQ TSC1 NLGN1 DICER1 SHANK3 PRR12 KIFAP3 NLGN3 CELSR3 PTPRF PIAS3 NETO2 GLRA1 SCN8A FGFR1 BSN SEZ6L	1.04e-04	1018	160	20	GO:0098794
GeneOntologyCellularComponent	excitatory synapse	NLGN1 SHANK3 NLGN3 PTPRF SCN8A BSN	1.75e-04	107	160	6	GO:0060076
GeneOntologyCellularComponent	postsynaptic membrane	GABRB2 GLRA3 NLGN1 SHANK3 NLGN3 CELSR3 PTPRF NETO2 GLRA1 SCN8A SEZ6L	2.97e-04	405	160	11	GO:0045211
GeneOntologyCellularComponent	asymmetric synapse	INPP4A TSC1 NLGN1 DICER1 SHANK3 PRR12 NLGN3 CELSR3 PTPRF NETO2 SCN8A BSN	3.17e-04	477	160	12	GO:0032279
GeneOntologyCellularComponent	neuron to neuron synapse	INPP4A TSC1 NLGN1 DICER1 SHANK3 PRR12 NLGN3 CELSR3 PTPRF NETO2 SCN8A BSN	7.18e-04	523	160	12	GO:0098984
GeneOntologyCellularComponent	postsynaptic density	INPP4A TSC1 NLGN1 DICER1 SHANK3 PRR12 CELSR3 PTPRF NETO2 SCN8A BSN	7.28e-04	451	160	11	GO:0014069
GeneOntologyCellularComponent	chloride channel complex	GABRB2 GLRA3 CLCN2 GLRA1	9.52e-04	57	160	4	GO:0034707
Domain	Cadherin	PCDHGB5 PCDHGB1 CDHR5 FREM3 CELSR3 DCHS1 DSG4	7.34e-05	118	161	7	IPR002126
Domain	Serine_rich	CASS4 BCAR1	2.20e-04	3	161	2	IPR014928
Domain	Serine_rich	CASS4 BCAR1	2.20e-04	3	161	2	PF08824
Domain	AT_hook	PATZ1 PRR12 KMT2C	3.24e-04	16	161	3	PF02178
Domain	Cadherin_CS	PCDHGB5 PCDHGB1 CDHR5 CELSR3 DCHS1 DSG4	3.64e-04	109	161	6	IPR020894
Domain	HMGI_Y	PATZ1 KMT2C	4.38e-04	4	161	2	PS00354
Domain	CAS_DUF3513	CASS4 BCAR1	4.38e-04	4	161	2	IPR021901
Domain	Glycine_rcpt_A	GLRA3 GLRA1	4.38e-04	4	161	2	IPR008127
Domain	DUF3513	CASS4 BCAR1	4.38e-04	4	161	2	PF12026
Domain	CADHERIN_1	PCDHGB5 PCDHGB1 CDHR5 CELSR3 DCHS1 DSG4	4.42e-04	113	161	6	PS00232
Domain	CADHERIN_2	PCDHGB5 PCDHGB1 CDHR5 CELSR3 DCHS1 DSG4	4.63e-04	114	161	6	PS50268
Domain	-	PCDHGB5 PCDHGB1 CDHR5 CELSR3 DCHS1 DSG4	4.63e-04	114	161	6	2.60.40.60
Domain	CA	PCDHGB5 PCDHGB1 CDHR5 CELSR3 DCHS1 DSG4	4.85e-04	115	161	6	SM00112
Domain	Cadherin-like	PCDHGB5 PCDHGB1 CDHR5 CELSR3 DCHS1 DSG4	5.08e-04	116	161	6	IPR015919
Pathway	REACTOME_ASPIRIN_ADME	UGT2B7 UGT3A2 ABCC2 ACSM2A ACSM2B	3.56e-05	44	121	5	M45014
Pathway	REACTOME_ASPIRIN_ADME	UGT2B7 UGT3A2 ABCC2 ACSM2A ACSM2B	3.98e-05	45	121	5	MM15694
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SYNRG CEBPB DUSP5 HECTD4 RAPGEF1 DGKQ ATG2A MED13L ACOX3 PLEKHH3 GGT7 PRR12 PLEKHG1 KMT2C CELSR3 PTPRF SCN8A HELZ2 FGFR1 HCFC1	2.44e-07	1105	162	20	35748872
Pubmed	A census of human transcription factors: function, expression and evolution.	HHEX CEBPB PATZ1 FOSB IRF8 MEIS3 YY1 MLXIPL NFATC2 SP6 NKX2-5 DMRTA2 OLIG1 ZBED1 FOXL1 NPAS1 FOXC2	1.31e-06	908	162	17	19274049
Pubmed	Divergent hTAFII31-binding motifs hidden in activation domains.	CEBPB NFATC2 HCFC1	5.46e-06	8	162	3	10821850
Pubmed	NPAS1 represses the generation of specific subtypes of cortical interneurons.	RELN FGFR1 OLIG1 NPAS1	9.84e-06	29	162	4	25467980
Pubmed	SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome.	RASA1 BCAR1 SLAMF1 FGFR1	1.47e-05	32	162	4	22974441
Pubmed	The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse.	MTHFSD NKX2-5 FOXL1 FOXC2	1.47e-05	32	162	4	23369715
Pubmed	Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk.	RAPGEF1 BCAR1 FGFR1	1.59e-05	11	162	3	10464310
Pubmed	Behavioral phenotypes of genetic mouse models of autism.	NLGN1 SHANK3 NLGN3	1.59e-05	11	162	3	26403076
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PRUNE2 MIA3 RASA1 MID2 PCDHGB1 INPP4A HECTD4 L2HGDH MEIS3 WDR25 BCAR1 PPM1H LRCH3 KMT2C NLGN3 SLC19A1 KIAA1217 FOLH1B TANGO2 NLK	2.16e-05	1489	162	20	28611215
Pubmed	Characterization of the glycinergic input to bipolar cells of the mouse retina.	GLRA3 GLRA1	2.16e-05	2	162	2	16420443
Pubmed	Transmembrane tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas.	BCAR1 PTPRF	2.16e-05	2	162	2	10320483
Pubmed	Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3.	NLGN1 NLGN3	2.16e-05	2	162	2	35992071
Pubmed	Transcriptome profiling of mouse brains with qkI-deficient oligodendrocytes reveals major alternative splicing defects including self-splicing.	OLIG1 QKI	2.16e-05	2	162	2	28790308
Pubmed	Phosphorylation of α3 glycine receptors induces a conformational change in the glycine-binding site.	GLRA3 GLRA1	2.16e-05	2	162	2	23834509
Pubmed	MicroRNA-mediated control of oligodendrocyte differentiation.	DICER1 OLIG1	2.16e-05	2	162	2	20223198
Pubmed	Endothelial dysfunction in murine model of systemic sclerosis: tight-skin mice 1.	BLOC1S6 FBN1	2.16e-05	2	162	2	12485443
Pubmed	Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism.	NLGN1 NLGN3	2.16e-05	2	162	2	22983708
Pubmed	HDAC inhibitor trichostatin A suppresses osteoclastogenesis by upregulating the expression of C/EBP-β and MKP-1.	CEBPB DUSP1	2.16e-05	2	162	2	22172035
Pubmed	Pharmacogenetic impact of UDP-glucuronosyltransferase metabolic pathway and multidrug resistance-associated protein 2 transport pathway on mycophenolic acid in thoracic transplant recipients: an exploratory study.	UGT2B7 ABCC2	2.16e-05	2	162	2	20973683
Pubmed	Reduced susceptibility to induced seizures in the Neuroligin-3(R451C) mouse model of autism.	NLGN1 NLGN3	2.16e-05	2	162	2	25592157
Pubmed	Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.	ACSM2A ACSM2B	2.16e-05	2	162	2	19634011
Pubmed	Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia.	NLGN1 NLGN3	2.16e-05	2	162	2	11329178
Pubmed	Characterization of the neuroligin gene family expression and evolution in zebrafish.	NLGN1 NLGN3	2.16e-05	2	162	2	20034102
Pubmed	Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome.	FOXL1 FOXC2	2.16e-05	2	162	2	11078474
Pubmed	Identifying DUSP-1 and FOSB as hub genes in immunoglobulin A nephropathy by WGCNA and DEG screening and validation.	FOSB DUSP1	2.16e-05	2	162	2	35910761
Pubmed	Genetic polymorphisms of MRP2 and UGT2B7 and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid.	UGT2B7 ABCC2	2.16e-05	2	162	2	19730281
Pubmed	Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis.	STIM2 NFATC2	2.16e-05	2	162	2	31464639
Pubmed	Impact of UGT2B7 and ABCC2 genetic polymorphisms on mycophenolic acid metabolism in Chinese renal transplant recipients.	UGT2B7 ABCC2	2.16e-05	2	162	2	30345879
Pubmed	Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting.	GLRA3 GLRA1	2.16e-05	2	162	2	19959465
Pubmed	Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia.	DUSP1 DUSP5	2.16e-05	2	162	2	31330530
Pubmed	FOXC2 and CLIP4 : a potential biomarker for synchronous metastasis of ≤7-cm clear cell renal cell carcinomas.	CLIP4 FOXC2	2.16e-05	2	162	2	27283491
Pubmed	Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G.	RAPGEF1 BCAR1	2.16e-05	2	162	2	9748234
Pubmed	Noise-Induced Dysregulation of Quaking RNA Binding Proteins Contributes to Auditory Nerve Demyelination and Hearing Loss.	OLIG1 QKI	2.16e-05	2	162	2	29437856
Pubmed	CAS proteins in health and disease: an update.	CASS4 BCAR1	2.16e-05	2	162	2	24962474
Pubmed	The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.	ACSM2A ACSM2B	2.16e-05	2	162	2	16521160
Pubmed	Probing glycine receptor stoichiometry in superficial dorsal horn neurones using the spasmodic mouse.	GLRA3 GLRA1	2.16e-05	2	162	2	21486794
Pubmed	Early emphysema in the tight skin and pallid mice: roles of microfibril-associated glycoproteins, collagen, and mechanical forces.	BLOC1S6 FBN1	2.16e-05	2	162	2	16439805
Pubmed	Isoform-selective upregulation of mast cell chymase in the development of skin fibrosis in scleroderma model mice.	BLOC1S6 FBN1	2.16e-05	2	162	2	11168806
Pubmed	A negative feedback loop of transcription factors specifies alternative dendritic cell chromatin States.	CEBPB IRF8	2.16e-05	2	162	2	25453760
Pubmed	Induction of skin fibrosis and autoantibodies by infusion of immunocompetent cells from tight skin mice into C57BL/6 Pa/Pa mice.	BLOC1S6 FBN1	2.16e-05	2	162	2	8155252
Pubmed	The identification of C/EBPbeta as a transcription factor necessary for the induction of MAPK phosphatase-1 by toll-like receptor-4 ligand.	CEBPB DUSP1	2.16e-05	2	162	2	18761321
Pubmed	Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.	ACSM2A ACSM2B	2.16e-05	2	162	2	29948332
Pubmed	Effects of D-4F on vasodilation, oxidative stress, angiostatin, myocardial inflammation, and angiogenic potential in tight-skin mice.	BLOC1S6 FBN1	2.16e-05	2	162	2	17496220
Pubmed	Postsynaptic Neuroligin1 regulates presynaptic maturation.	CEBPB NLGN1	2.16e-05	2	162	2	19628693
Pubmed	Studies of the cellular immune response to heparan sulfate proteoglycan in the tight skin mouse.	BLOC1S6 FBN1	2.16e-05	2	162	2	8370075
Pubmed	YY1 Complex Promotes Quaking Expression via Super-Enhancer Binding during EMT of Hepatocellular Carcinoma.	YY1 QKI	2.16e-05	2	162	2	30760518
Pubmed	Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation.	NLGN1 FGFR1	2.16e-05	2	162	2	32324534
Pubmed	Advancing the understanding of autism disease mechanisms through genetics.	TSC1 SHANK3 NLGN3	2.74e-05	13	162	3	27050589
Pubmed	Translational animal models of autism and neurodevelopmental disorders.	NLGN1 SHANK3 NLGN3	3.48e-05	14	162	3	23226954
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	PRUNE2 ATG2A RAD54L2 BCAR1 LMTK3 OTUD7B PIAS3 NKX2-5 BSN NYAP1	3.66e-05	430	162	10	35044719
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	CEBPB FOSB IRF8 MEIS3 YY1 NFATC2 ZIC5 NKX2-5 DMRTA2 ZBED1 FOXC2	5.30e-05	544	162	11	28473536
Pubmed	Effects of Venlafaxine on the Size of Brain and Expression of SHANK3, TUBB5 and DDC Genes in BALB/c Mice.	DDC SHANK3	6.45e-05	3	162	2	37601086
Pubmed	Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties.	NLGN1 NLGN3	6.45e-05	3	162	2	28607166
Pubmed	Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3.	SLC39A4 SHANK3	6.45e-05	3	162	2	28345660
Pubmed	SCN1A, ABCC2 and UGT2B7 gene polymorphisms in association with individualized oxcarbazepine therapy.	UGT2B7 ABCC2	6.45e-05	3	162	2	25823783
Pubmed	Embryologic Origin Influences Smooth Muscle Cell Phenotypic Modulation Signatures in Murine Marfan Syndrome Aortic Aneurysm.	FBN1 NKX2-5	6.45e-05	3	162	2	35861960
Pubmed	A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML.	FLT3 FGFR1	6.45e-05	3	162	2	35906694
Pubmed	Acceleration of chronic myeloproliferation by enforced expression of Meis1 or Meis3 in Icsbp-deficient bone marrow cells.	IRF8 MEIS3	6.45e-05	3	162	2	18223676
Pubmed	The CCAAT/enhancer binding protein beta (C/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4.	CEBPB NFATC2	6.45e-05	3	162	2	20371871
Pubmed	Somatic Mutations and Intratumoral Heterogeneity of Cancer-Related Genes NLK, YY1 and PA2G4 in Gastric and Colorectal Cancers.	YY1 NLK	6.45e-05	3	162	2	31828582
Pubmed	Prenatal glucocorticoid exposure selectively impairs neuroligin 1-dependent neurogenesis by suppressing astrocytic FGF2-neuronal FGFR1 axis.	NLGN1 FGFR1	6.45e-05	3	162	2	35562616
Pubmed	YAP1 synergize with YY1 transcriptional co-repress DUSP1 to induce osimertinib resistant by activating the EGFR/MAPK pathway and abrogating autophagy in non-small cell lung cancer.	DUSP1 YY1	6.45e-05	3	162	2	37215986
Pubmed	Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals.	NLGN1 BSN	6.45e-05	3	162	2	34320240
Pubmed	Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits.	NLGN1 NLGN3	6.45e-05	3	162	2	29100073
Pubmed	Long noncoding RNA KB-1460A1.5 inhibits glioma tumorigenesis via miR-130a-3p/TSC1/mTOR/YY1 feedback loop.	TSC1 YY1	6.45e-05	3	162	2	34728310
Pubmed	C-440T/T-331C polymorphisms in the UGT1A9 gene affect the pharmacokinetics of mycophenolic acid in kidney transplantation.	UGT2B7 ABCC2	6.45e-05	3	162	2	17924828
Pubmed	Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses.	NLGN1 NLGN3	6.45e-05	3	162	2	35704570
Pubmed	TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1.	BLOC1S6 FBN1	6.45e-05	3	162	2	17884256
Pubmed	Lack of endothelial cell apoptosis in the dermis of tight skin 1 and tight skin 2 mice.	BLOC1S6 FBN1	6.45e-05	3	162	2	10088787
Pubmed	Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit.	GLRA3 GLRA1	6.45e-05	3	162	2	17154252
Pubmed	Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice.	GLRA3 GLRA1	6.45e-05	3	162	2	17920294
Pubmed	α-MSH and Foxc2 promote fatty acid oxidation through C/EBPβ negative transcription in mice adipose tissue.	CEBPB FOXC2	6.45e-05	3	162	2	27819350
Pubmed	Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses.	NLGN1 NLGN3	6.45e-05	3	162	2	26291161
Pubmed	Quaking Regulates Neurofascin 155 Expression for Myelin and Axoglial Junction Maintenance.	OLIG1 QKI	6.45e-05	3	162	2	27053216
Pubmed	Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses.	NLGN1 NLGN3	6.45e-05	3	162	2	17897391
Pubmed	Neuroligins determine synapse maturation and function.	NLGN1 NLGN3	6.45e-05	3	162	2	16982420
Pubmed	De novo SCN1A, SCN8A, and CLCN2 mutations in childhood absence epilepsy.	CLCN2 SCN8A	6.45e-05	3	162	2	31054517
Pubmed	Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.	UGT2B7 ABCC2	6.45e-05	3	162	2	17241877
Pubmed	Control of IL-17 receptor signaling and tissue inflammation by the p38α-MKP-1 signaling axis in a mouse model of multiple sclerosis.	DUSP1 IL17RA	6.45e-05	3	162	2	25737586
Pubmed	Impact of RFC1, MTHFR, and MTHFD1 polymorphism on unexplained pregnancy loss (UPL): comparative analysis of maternal and fetal components using mother-abortus paired samples.	MTHFD1 SLC19A1	6.45e-05	3	162	2	30388610
Pubmed	UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients.	UGT2B7 ABCC2	6.45e-05	3	162	2	23131697
Pubmed	CCAAT enhancer binding protein and nuclear factor of activated T cells regulate HIV-1 LTR via a novel conserved downstream site in cells of the monocyte-macrophage lineage.	CEBPB NFATC2	6.45e-05	3	162	2	24551078
Pubmed	YY1 Expression Is Sufficient for the Maintenance of Cardiac Progenitor Cell State.	YY1 NKX2-5	6.45e-05	3	162	2	28580685
Pubmed	Identification of de novo mutations and rare variants in hypoplastic left heart syndrome.	FOXL1 FOXC2	6.45e-05	3	162	2	21457232
Pubmed	Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP.	IRF8 NFATC2	6.45e-05	3	162	2	12876285
Pubmed	UGT1A9 -275T>A/-2152C>T polymorphisms correlate with low MPA exposure and acute rejection in MMF/tacrolimus-treated kidney transplant patients.	UGT2B7 ABCC2	6.45e-05	3	162	2	19494809
Pubmed	The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice.	FGFR1 NPAS1	6.45e-05	3	162	2	16172381
Pubmed	Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism.	NLGN1 NLGN3	6.45e-05	3	162	2	27217145
Pubmed	Validation of nasal potential difference measurements in gut-corrected CF knockout mice.	BLOC1S6 FBN1	6.45e-05	3	162	2	18458238
Pubmed	Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formation.	NKX2-5 FOXC2	6.45e-05	3	162	2	26299482
Pubmed	STIM2 promotes the invasion and metastasis of breast cancer cells through the NFAT1/TGF-β1 pathway.	STIM2 NFATC2	6.45e-05	3	162	2	35818214
Pubmed	Hearing and vision in neurological mutant mice: a method for their evaluation.	RELN QKI	6.45e-05	3	162	2	5957201
Pubmed	A scanning electron microscopic investigation of genetic emphysema in tight-skin, pallid, and beige mice, three different C57 BL/6J mutants.	BLOC1S6 FBN1	6.45e-05	3	162	2	8780155
Pubmed	Phosphorylated C/EBPβ influences a complex network involving YY1 and USF2 in lung epithelial cells.	CEBPB YY1	6.45e-05	3	162	2	23560079
Pubmed	Neutrophil lysosomal dysfunctions in mutant C57 Bl/6J mice: interstrain variations in content of lysosomal elastase, cathepsin G and their inhibitors.	BLOC1S6 FBN1	6.45e-05	3	162	2	8166647
Pubmed	Association between SNPs in genes involved in folate metabolism and preterm birth risk.	MTHFD1 SLC19A1	6.45e-05	3	162	2	25730024
Pubmed	Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development.	FOXL1 FOXC2	6.45e-05	3	162	2	8674414
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	PATZ1 RFC4 MEN1 KMT2C KIAA1217 HCFC1	6.59e-05	146	162	6	23892456
Pubmed	Loss of transforming growth factor-beta 2 leads to impairment of central synapse function.	NLGN1 NLGN3 GLRA1	7.69e-05	18	162	3	18854036
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	STIM2 UNC5B RAPGEF1 SHISA2 TSC1 CDHR5 LLGL1 CLCN2 PTPRF SLC19A1 ABCC2	7.90e-05	569	162	11	30639242
Cytoband	5q34	GABRB2 DUSP1 NKX2-5	1.95e-04	32	161	3	5q34
Cytoband	16q24.1	MTHFSD IRF8 FOXC2	2.14e-04	33	161	3	16q24.1
Cytoband	20q13.1	CEBPB SLC2A10	5.40e-04	10	161	2	20q13.1
GeneFamily	Cas scaffolding proteins	CASS4 BCAR1	2.43e-04	4	116	2	469
GeneFamily	HRAS like suppressor family	PLAAT1 PLAAT5	4.03e-04	5	116	2	1227
GeneFamily	Glycine receptors	GLRA3 GLRA1	4.03e-04	5	116	2	868
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	FLT3 LMTK3 FGFR1	2.14e-03	40	116	3	321
GeneFamily	MAP kinase phosphatases	DUSP1 DUSP5	2.16e-03	11	116	2	895
GeneFamily	UPF1 like RNA helicases	HELZ2 HELZ	2.16e-03	11	116	2	1169
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 RELN MIA3 INPP4A FOSB DUSP1 DUSP5 DDC MLXIPL PTPRF SEZ6L	1.16e-10	191	161	11	a251b134f67a0a1ef3a42f50042f128a17f20b22
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 RELN MIA3 INPP4A FOSB DUSP5 DDC MLXIPL PTPRF SEZ6L	2.09e-09	191	161	10	3387b95a3f2445c672d407922fdce3a91eabaef8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	2.96e-08	188	161	9	f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 RELN MIA3 INPP4A FOSB DDC MLXIPL PTPRF SEZ6L	2.96e-08	188	161	9	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	2.96e-08	188	161	9	0792432cd4c564dea1102241ea9884f7ced7658c
ToppCell	facs-Pancreas-Endocrine-24m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 RELN INPP4A FOSB DUSP1 DUSP5 DDC MLXIPL SEZ6L	3.10e-08	189	161	9	010fdd70e9d0e21b856306a29ff877776a480319
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma-early_osteoblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	MXRA5 COL12A1 UNC5B ITGA10 SHISA2 OLFML3 KIAA1217 FGFR1 FOXC2	3.71e-08	193	161	9	5e46a9f65e85aca78f825fdef88a95b97eec8743
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 NLGN1 MLXIPL ABCC2 ACSM2A ACSM2B	2.64e-07	176	161	8	1595dbeee336a81e581325d63208ec6262664ee9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 NLGN1 MLXIPL ABCC2 ACSM2A ACSM2B	2.75e-07	177	161	8	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	COVID-19-kidney-PCT-S1/S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 CDHR5 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	2.87e-07	178	161	8	23a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CAPN12 PRUNE2 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	3.13e-07	180	161	8	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	COVID-19-kidney-tDL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CAPN12 PRUNE2 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	3.13e-07	180	161	8	864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 NLGN1 DDC MLXIPL ACSM2A ACSM2B	3.40e-07	182	161	8	e1e58176f533092b6b974ca1ce8b02192a6e193d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 NLGN1 DDC MLXIPL ACSM2A ACSM2B	3.40e-07	182	161	8	57bb5a2da976464ba7c4460106bd9f692008ebd9
ToppCell	COVID-19-kidney-Mito-rich_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 CDHR5 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	3.85e-07	185	161	8	1bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 NLGN1 MLXIPL ABCC2 ACSM2A ACSM2B	4.02e-07	186	161	8	8287146f0ba415ea04475588117d4668ae00f75c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 NLGN1 MLXIPL ABCC2 ACSM2A ACSM2B	4.02e-07	186	161	8	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN FLT3 NETO2 KIAA1217 ST6GALNAC5 RNASET2 QKI NPAS1	4.18e-07	187	161	8	85f1678338a47d91e296f0620d4887f057eb7e70
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 NLGN1 MLXIPL ABCC2 ACSM2A ACSM2B	4.18e-07	187	161	8	1b82920588f9e26ef1db244d452736d75fcfd342
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 NLGN1 MLXIPL ABCC2 ACSM2A ACSM2B	4.18e-07	187	161	8	71eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	4.18e-07	187	161	8	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ITGA10 SHANK3 PPM1H PLEKHG1 ART1 KIAA1217 SP6 FOXL1	4.18e-07	187	161	8	97b2463fb37e7196dd2f92553acf8e7bc3ec40dd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	4.18e-07	187	161	8	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	COVID-19-kidney-Mito-rich_PCT\|kidney / Disease (COVID-19 only), tissue and cell type	PRUNE2 CDHR5 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	4.18e-07	187	161	8	738ec2611b4be6a08eedad16b57fba84e1f11fef
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 NLGN1 MLXIPL ABCC2 ACSM2A ACSM2B	4.18e-07	187	161	8	c1e4c0345f9bfa0538730bad5ff3fa5240168b25
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	4.53e-07	189	161	8	204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	4.53e-07	189	161	8	13fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	CAPN12 PRUNE2 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	4.53e-07	189	161	8	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN FLT3 NETO2 KIAA1217 ST6GALNAC5 RNASET2 QKI NPAS1	5.31e-07	193	161	8	d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN MIA3 DDC GIPR KMT2C MLXIPL PTPRF SEZ6L	5.74e-07	195	161	8	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	HHEX CEBPB FOSB IRF8 OLFML3 NFATC2 RNASET2 IL17RA	6.95e-07	200	161	8	fe22f7c97f4e37dfa7881d0f1d9245c1237d873b
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLT3 INPP4A DUSP5 IRF8 CDHR5 WDFY4 RNASET2	3.02e-06	171	161	7	4fd2c7977c512c51507f055fc74b111c0228ed8b
ToppCell	11.5-Airway-Epithelial-Basal_cell\|Airway / Age, Tissue, Lineage and Cell class	GABRB2 CAPN12 NPHS1 PCDHGB1 AP1M2 LMTK3 DMRTA2	3.14e-06	172	161	7	9d4d92e2d16dfc8a394f2641653bb97de20a2530
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL12A1 MEIS3 NLGN1 OLFML3 MLXIPL FBN1 FGFR1	3.14e-06	172	161	7	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	facs-Heart-RV-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN IRF8 AP1M2 WDR25 SLAMF1 LMBR1L SP6	3.14e-06	172	161	7	2dcc9d67d6ecc35940eabbc8ed528f5f884f6976
ToppCell	facs-Heart-RV-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN IRF8 AP1M2 WDR25 SLAMF1 LMBR1L SP6	3.14e-06	172	161	7	64d2edbd8e2640b76225597883b1a524e6b1dd3b
ToppCell	facs-Heart-RV-18m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN IRF8 AP1M2 WDR25 SLAMF1 LMBR1L SP6	3.14e-06	172	161	7	d061ea21bee179df5a525842e9a48621a8e1461b
ToppCell	Healthy/Control-MAIT\|Healthy/Control / Disease group and Cell class	FOSB DUSP1 DUSP5 ATG2A PRDM8 KIAA1217 NYAP1	3.26e-06	173	161	7	56247c1e07477a8922fe2e3950ae05e2217fd77c
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-epithelial_progenitor_cell-CLDN10+_cells\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GABRB2 NPHS1 HHEX RELN AP1M2 UGT2B7 PLAAT5	4.08e-06	179	161	7	7eca1e19ae6b5b1f18c721691dc3e860705628f2
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 NLGN1 MLXIPL ACSM2A ACSM2B	4.08e-06	179	161	7	d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 CDHR5 NLGN1 MLXIPL ABCC2 ACSM2A ACSM2B	4.24e-06	180	161	7	f8bdfd7bf7b3d52c659a29d8f5f80858e79da83e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CDHR5 NLGN1 DDC MLXIPL ABCC2 ACSM2A ACSM2B	4.24e-06	180	161	7	1363b3254470f6ff98630d1df83a1bdbacc137e0
ToppCell	facs-Marrow-B-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLAAT1 NLGN1 OLFML3 GGT7 MLXIPL NLGN3 OLIG1	4.24e-06	180	161	7	c54af6fb11484dacd3efa1f10a487376ff820a5e
ToppCell	facs-Marrow-B-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLAAT1 NLGN1 OLFML3 GGT7 MLXIPL NLGN3 OLIG1	4.24e-06	180	161	7	07ac979b21be2425294d9818c48b5a1e6f014c19
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 NLGN1 MLXIPL ACSM2A ACSM2B	4.56e-06	182	161	7	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 DDC MLXIPL ACSM2A ACSM2B	4.72e-06	183	161	7	d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRUNE2 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	4.72e-06	183	161	7	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 CDHR5 NLGN1 MLXIPL ACSM2A ACSM2B	4.90e-06	184	161	7	9434731f651820b05335085582960f08fbf895de
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-conventional_dendritic_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLT3 IRF8 WDFY4 BLOC1S6 NFATC2 CBX6 RNASET2	5.07e-06	185	161	7	209c7d769dd01c349f0a6d147ac9d6225a85160f
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLT3 IRF8 WDFY4 BLOC1S6 NFATC2 CBX6 RNASET2	5.07e-06	185	161	7	1f37191eeddaf95e1ad1a206fee86525a2e94e51
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)-DC1_L.1.2.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLT3 IRF8 WDFY4 BLOC1S6 NFATC2 CBX6 RNASET2	5.07e-06	185	161	7	70d3f804b43a8843c5af53aefe677fdfc8bb61ff
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL9L CEBPB DUSP1 DUSP5 SLC39A4 PTPRF CBX6	5.26e-06	186	161	7	bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 PRUNE2 NLGN1 MLXIPL UGT2B7 ACSM2A ACSM2B	5.26e-06	186	161	7	f28d72b47624b69a580b4429e2be560a26898591
ToppCell	COVID-19-kidney-tDL\|kidney / Disease (COVID-19 only), tissue and cell type	CAPN12 PRUNE2 NLGN1 UGT2B7 ABCC2 ACSM2A ACSM2B	5.44e-06	187	161	7	d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	6.25e-06	191	161	7	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 NLGN1 MLXIPL UGT2B7 ABCC2 ACSM2A ACSM2B	6.25e-06	191	161	7	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 MIA3 FOSB DDC MLXIPL PTPRF SEZ6L	6.47e-06	192	161	7	1304e69c92cef3bd8c82e3c035a7562f5440139a
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SLC25A20 SLC39A4 RFC4 DICER1 GGT7 CLIP4 PRR12	6.47e-06	192	161	7	efbd52b3d2b6d3fb9ed6bc3f36aca9f4f1fcbc49
ToppCell	P03-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CASS4 CEBPB FOSB IRF8 SHISA2 OLFML3 FBN1	6.47e-06	192	161	7	2802fae55683345ff94a1ecf73b6fbee4f17481e
ToppCell	P03-Mesenchymal-mesenchymal_fibroblast\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CASS4 CEBPB FOSB IRF8 SHISA2 OLFML3 FBN1	6.47e-06	192	161	7	e79f2253e084a9ab9afcaf7ec42a5012ade42d36
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN FLT3 NETO2 KIAA1217 ST6GALNAC5 RNASET2 NPAS1	6.69e-06	193	161	7	010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN FLT3 NETO2 KIAA1217 ST6GALNAC5 RNASET2 NPAS1	6.69e-06	193	161	7	3ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 MIA3 FOSB DDC MLXIPL PTPRF SEZ6L	6.92e-06	194	161	7	92b39a935e8c577eb1123d706d168fa13cf3344c
ToppCell	severe-B_intermediate\|World / disease stage, cell group and cell class	HHEX DUSP1 IRF8 WDFY4 PLEKHG1 RNASET2 NPAS1	7.16e-06	195	161	7	ce4bd004ceb05a269387adfed255d7fa393afcc6
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HHEX STIM2 FOSB DUSP1 IRF8 WDFY4 PLEKHG1	7.16e-06	195	161	7	481989d2e5bd2582da3d86b0155c4d6615317067
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HHEX STIM2 FOSB DUSP1 IRF8 WDFY4 PLEKHG1	7.16e-06	195	161	7	6108a27523d1b93a7fbe35cb95704a5ad9071e3c
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 MIA3 BCAR1 LMTK3 DDC MLXIPL SEZ6L	7.16e-06	195	161	7	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN MIA3 DDC KMT2C MLXIPL PTPRF SEZ6L	7.16e-06	195	161	7	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	facs-Lung-nan-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN MID2 UNC5B SHANK3 PLEKHG1 QKI FOXC2	7.16e-06	195	161	7	7f9b7f15006610ad591063d90e90367bd6083c7f
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 CDHR5 DDC MLXIPL UGT2B7 ACSM2A ACSM2B	7.40e-06	196	161	7	4ebcaac758ed01d918de9c1cd383a84457b615f3
ToppCell	severe-B_intermediate\|severe / disease stage, cell group and cell class	HHEX DUSP1 IRF8 WDFY4 PLEKHG1 RNASET2 NPAS1	7.40e-06	196	161	7	8f59e51ca50bef4753f67cd1efdb02665805a120
ToppCell	10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	MXRA5 COL12A1 UNC5B ITGA10 OLFML3 FBN1 FGFR1	7.65e-06	197	161	7	c165c6fd12dc649b39e920d8528e2eb65c61956b
ToppCell	11.5-Airway-Mesenchymal-Mesenchyme_SERPINF1-high\|Airway / Age, Tissue, Lineage and Cell class	MXRA5 COL12A1 OLFML3 PRDM8 FBN1 NKD2 FGFR1	7.65e-06	197	161	7	9a053a32ff9c3a85ef9a3382453acd619cc48546
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PDZD7 NLGN1 OLFML3 NLGN3 FBN1 NYAP1 PLAAT5	8.17e-06	199	161	7	45c3b853900d8c3d5965117d904e3714100138bc
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	MXRA5 COL12A1 UNC5B ITGA10 OLFML3 FGFR1 FOXC2	8.45e-06	200	161	7	3c898e81444b001835c3f1bbc68183078701b135
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN FLT3 NETO2 KIAA1217 RNASET2 QKI NPAS1	8.45e-06	200	161	7	347a510755374c6a66acee326565dfc447993f18
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal-BMP_responsible_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	HHEX CEBPB IRF8 OLFML3 NFATC2 RNASET2 IL17RA	8.45e-06	200	161	7	26251ed8c7fa7e87973d6f59bd398c88ad025395
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	MXRA5 COL12A1 UNC5B ITGA10 OLFML3 FGFR1 FOXC2	8.45e-06	200	161	7	3eca8ffeb41b664fbdbbd70b375c5d953503ab29
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PLAAT1 DDC CELSR3 OR2AT4 NETO2 NYAP1	1.31e-05	142	161	6	819e983688d126d89a71abc03d72525cc759a347
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Tacstd2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RELN NFATC2 NETO2 ST6GALNAC5 FAM181B NPAS1	1.36e-05	143	161	6	24fd24846fbef049af669a57d42fcc18928d2b27
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_26.46.91\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	OLFML3 GIPR PRDM8 NKD2 FOXL1 FOXC2	1.66e-05	148	161	6	df6bc387cad2f81520bd8bbd009c8e63225dbadb
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNRG GRWD1 ZBTB47 RAD54L2 PLEKHH3 METTL8	2.66e-05	161	161	6	9f02b94e29e60d50e92eaa748ebf0c36d3671bb3
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCDHGB1 BUD23 PRDM8 FBN1 FGFR1 METTL8	2.76e-05	162	161	6	56f1789e69a6cb29956e46aba92b290847327c1f
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-Trm_Th1/Th17\|bone_marrow / Manually curated celltypes from each tissue	FOSB DUSP1 DUSP5 MEIS3 SLAMF1 KIAA1217	2.86e-05	163	161	6	4d1fd0b1246833723b938eca0cb246e937380e12
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	MXRA5 COL12A1 SHISA2 KIAA1217 ST6GALNAC5 BSN	2.96e-05	164	161	6	9b4a6007abae992db871d9f6f731d5af724de30d
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DDC GIPR MLXIPL NOXO1 CELSR3 SP6	3.06e-05	165	161	6	4b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCell	356C-Myeloid-Dendritic-cDC1\|356C / Donor, Lineage, Cell class and subclass (all cells)	FLT3 IRF8 WDFY4 PPM1H BLOC1S6 CBX6	3.16e-05	166	161	6	0590e404f45afce90e20f93f90a3def83949c66b
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	FLT3 LMTK3 SHANK3 CLIP4 PRDM8 NYAP1	3.27e-05	167	161	6	9efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCell	Cerebellum-Neuronal-Inhibitory\|Cerebellum / BrainAtlas - Mouse McCarroll V32	FLT3 LMTK3 SHANK3 CLIP4 PRDM8 NYAP1	3.27e-05	167	161	6	904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCell	facs-Thymus-nan-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 PCDHGB1 IRF8 MMP20 WDFY4 PLD2	3.38e-05	168	161	6	d72cd8238fa793bb3e4add4c59eaaaadcea9930d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DDC MLXIPL ABCC2 ACSM2A ACSM2B	3.38e-05	168	161	6	fa0d251693935116adf633d02b7ec4a295100865
ToppCell	facs-Thymus-nan-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 PCDHGB1 IRF8 MMP20 WDFY4 PLD2	3.38e-05	168	161	6	c34c52165485f612add7a3e35a175d5a6e365e7c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SHANK3 SLC2A10 NETO2 SP6 DCHS1 FGFR1	3.38e-05	168	161	6	37249f38f8f04ec5743097259de67b106ca2b02f
ToppCell	facs-Thymus-nan-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 PCDHGB1 IRF8 MMP20 WDFY4 PLD2	3.38e-05	168	161	6	d2afc097ae1243574210be6a751685f949ea941a
ToppCell	Endothelial-B-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	RELN SHANK3 FBN1 ZIC5 ACSM2B FOXC2	3.50e-05	169	161	6	95c617143e1fbdd1d55a93ffdcc210e0be37cf2f
ToppCell	COVID-19-Heart-Adipocyte\|Heart / Disease (COVID-19 only), tissue and cell type	PRUNE2 PRR23C CLIP4 MLXIPL PTPRF PLAAT5	3.50e-05	169	161	6	bd39f85b48207955f80ca120a11e15a0124117b9
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLT3 INPP4A DUSP5 IRF8 CDHR5 WDFY4	3.62e-05	170	161	6	92e765ae0d3adb38d3b22fddb873fd5ccad3fd44
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLT3 INPP4A DUSP5 IRF8 CDHR5 WDFY4	3.62e-05	170	161	6	9f8b215caa1afa3cd7104c06fca7cfd790640f66
ToppCell	Healthy/Control-MAIT\|World / Disease group and Cell class	FOSB DUSP5 ATG2A PRDM8 KIAA1217 NYAP1	3.74e-05	171	161	6	61515114b17816a8f9ef6a57262eb9e977b6ede4
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D122\|Adult / Lineage, Cell type, age group and donor	ITGA10 SHANK3 PLEKHG1 NETO2 KIAA1217 SP6	3.74e-05	171	161	6	bd20e85d36fa9d7ddc8afef6a1dea75efc9ee1dc
Disease	Intellectual Disability	GABRB2 INPP4A L2HGDH MED13L YY1 SHANK3 PRR12 KMT2C RNASET2 SCN8A PJA1 QKI	5.30e-06	447	157	12	C3714756
Disease	mesangial proliferative glomerulonephritis (biomarker_via_orthology)	RAPGEF1 FBN1 FGFR1	8.12e-06	8	157	3	DOID:4783 (biomarker_via_orthology)
Disease	X-21319 measurement	ACSM2A ACSM2B	2.81e-05	2	157	2	EFO_0800807
Disease	hepatocyte growth factor-like protein measurement	SLC25A20 RAD54L2 CELSR3 BSN	4.95e-05	38	157	4	EFO_0008154
Disease	cleft lip (is_implicated_in)	MTHFD1 SLC19A1 FGFR1	6.42e-05	15	157	3	DOID:9296 (is_implicated_in)
Disease	Epilepsy, Cryptogenic	GABRB2 FOSB L2HGDH TSC1 SCN8A	7.85e-05	82	157	5	C0086237
Disease	Awakening Epilepsy	GABRB2 FOSB L2HGDH TSC1 SCN8A	7.85e-05	82	157	5	C0751111
Disease	Aura	GABRB2 FOSB L2HGDH TSC1 SCN8A	7.85e-05	82	157	5	C0236018
Disease	X-11478 measurement	ACSM2A ACSM2B	8.41e-05	3	157	2	EFO_0021242
Disease	dextro-looped transposition of the great arteries (is_implicated_in)	MED13L SLC19A1	8.41e-05	3	157	2	DOID:0060770 (is_implicated_in)
Disease	Profound Mental Retardation	INPP4A L2HGDH MED13L YY1 SHANK3 SCN8A	1.03e-04	139	157	6	C0020796
Disease	Mental Retardation, Psychosocial	INPP4A L2HGDH MED13L YY1 SHANK3 SCN8A	1.03e-04	139	157	6	C0025363
Disease	Mental deficiency	INPP4A L2HGDH MED13L YY1 SHANK3 SCN8A	1.03e-04	139	157	6	C0917816
Disease	obsolete_red blood cell distribution width	FLT3 PATZ1 DUSP1 HECTD4 AP1M2 FREM3 PPM1H PLEKHG1 MLXIPL NOXO1 NKD2 CBX6 SLC19A1 KIAA1217 THG1L HELZ2 FBXO7 CRYBG1 FGFR1	1.05e-04	1347	157	19	EFO_0005192
Disease	nervous system disorder	NFATC2 SLC19A1 SCN8A ABCC2	1.84e-04	53	157	4	C0027765
Disease	3-hydroxyhexanoate measurement	ACSM2A ACSM2B	2.78e-04	5	157	2	EFO_0800378
Disease	Epilepsy	GABRB2 FOSB L2HGDH TSC1 SCN8A	2.99e-04	109	157	5	C0014544
Disease	indoleacetoylcarnitine measurement	ACSM2A ACSM2B	4.16e-04	6	157	2	EFO_0800106
Disease	insulin measurement, glucose tolerance test	HHEX GIPR	4.16e-04	6	157	2	EFO_0004307, EFO_0004467
Disease	Autistic Disorder	RELN TSC1 NLGN1 WDFY4 SHANK3 NLGN3 SLC19A1	5.16e-04	261	157	7	C0004352
Disease	tumor necrosis factor ligand superfamily member 6, soluble form measurement	CELSR3 BSN	5.80e-04	7	157	2	EFO_0020797
Disease	myocardial infarction	MIA3 HECTD4 BCAR1 PLEKHG1 PRDM8 NKX2-5 QKI FOXL1	5.98e-04	350	157	8	EFO_0000612
Disease	coronary artery disease	MIA3 HECTD4 BCAR1 CHKB OTUD7B GGT7 PLEKHG1 GIPR PRDM8 GUCY1A2 KIAA1217 SP6 DLEC1 BSN SEZ6L FOXL1	6.57e-04	1194	157	16	EFO_0001645
Disease	Cleft Palate	MED13L SLC19A1 FGFR1 FOXC2	9.34e-04	81	157	4	C0008925
Disease	mitral valve prolapse (is_implicated_in)	FBN1 DCHS1	9.88e-04	9	157	2	DOID:988 (is_implicated_in)
Disease	Pituitary Adenoma	DICER1 MEN1	9.88e-04	9	157	2	C0032000
Disease	cholestasis (implicated_via_orthology)	VPS18 ABCC2	9.88e-04	9	157	2	DOID:13580 (implicated_via_orthology)
Disease	Bipolar Disorder	GABRB2 RELN NLGN1 DDC MTHFD1 PIP4K2A SCN8A FGFR1 SEZ6L	1.08e-03	477	157	9	C0005586
Disease	autistic disorder (is_implicated_in)	GABRB2 RELN NLGN3	1.46e-03	42	157	3	DOID:12849 (is_implicated_in)
Disease	Neurodevelopmental Disorders	GABRB2 MED13L KMT2C SCN8A	1.56e-03	93	157	4	C1535926
Disease	age at diagnosis, osteonecrosis	GABRB2 RELN QKI	1.67e-03	44	157	3	EFO_0004259, EFO_0004918
Disease	tetralogy of Fallot (is_implicated_in)	MTHFD1 NKX2-5	2.11e-03	13	157	2	DOID:6419 (is_implicated_in)
Disease	diastolic blood pressure, alcohol consumption measurement	HECTD4 PLEKHG1 PRDM8	3.00e-03	54	157	3	EFO_0006336, EFO_0007878
Disease	Antihypertensive use measurement	STIM2 NLGN1 OLFML3 PLEKHG1 PRDM8 NFATC2	3.03e-03	265	157	6	EFO_0009927
Disease	Antithrombotic agent use measurement	HECTD4 BCAR1 PRDM8	3.17e-03	55	157	3	EFO_0009925
Disease	Tetralogy of Fallot	NKX2-5 FOXC2	3.21e-03	16	157	2	C0039685
Disease	Beta blocking agent use measurement	PLEKHG1 PRDM8 NFATC2 SP6	3.27e-03	114	157	4	EFO_0009929
Disease	HMG CoA reductase inhibitor use measurement	MIA3 MLXIPL PRDM8 SP6 UGT2B7	3.48e-03	189	157	5	EFO_0009932
Disease	Familial Progressive Myoclonic Epilepsy	TSC1 PRDM8	3.63e-03	17	157	2	C0751777
Disease	Atypical Inclusion-Body Disease	TSC1 PRDM8	3.63e-03	17	157	2	C0751776
Disease	Myoclonic Epilepsies, Progressive	TSC1 PRDM8	3.63e-03	17	157	2	C0751778
Disease	Biotin-Responsive Encephalopathy	TSC1 PRDM8	3.63e-03	17	157	2	C0751780
Disease	May-White Syndrome	TSC1 PRDM8	3.63e-03	17	157	2	C0751782
Disease	Dentatorubral-Pallidoluysian Atrophy	TSC1 PRDM8	3.63e-03	17	157	2	C0751781
Disease	von Willebrand factor measurement, coronary artery disease	MIA3 HECTD4 PRDM8 TAB1	3.70e-03	118	157	4	EFO_0001645, EFO_0004629
Disease	Action Myoclonus-Renal Failure Syndrome	TSC1 PRDM8	4.07e-03	18	157	2	C0751779
Disease	hypertension, white matter hyperintensity measurement	PLEKHG1 FOXL1 FOXC2	4.44e-03	62	157	3	EFO_0000537, EFO_0005665
Disease	type 1 diabetes mellitus (biomarker_via_orthology)	DUSP1 YY1	4.53e-03	19	157	2	DOID:9744 (biomarker_via_orthology)
Disease	lymphocyte:monocyte ratio	FLT3 CEBPB IRF8 DDC IL17RA RBM34	4.54e-03	288	157	6	EFO_0600088
Disease	systolic blood pressure, alcohol drinking	HECTD4 PLEKHG1 PRDM8 FBN1	4.94e-03	128	157	4	EFO_0004329, EFO_0006335

Protein segments in the cluster

Peptide	Gene	Start	Entry
RRPEHGGPPELFYDE	BUD23	6	O43709
LFLPPGEGLFPGVID	BAAT	151	Q14032
EGRPPIGVKFEIPYF	AP1M2	371	Q9Y6Q5
LPEIPSYGFLVPRGT	CASS4	306	Q9NQ75
GPGLLLAAPAAPYDA	CBX6	256	O95503
ALLPEFPRGPLDAYR	ACOX3	11	O15254
GPNGRDPLLEVYDVP	BCAR1	276	P56945
PGPGTLYDVPRERVL	BCAR1	381	P56945
PIRPIGIFSGYVDNP	ACSM2A	416	Q08AH3
PELFKSYGIPAPRGV	SPATA5	376	Q8NB90
LFVGGLPPGLSPEEY	DGKQ	501	P52824
DRLLPRPGPYLGDQA	GIPR	191	P48546
YPAGGLLRSQVPPFD	RAD54L2	1426	Q9Y4B4
PLVLRPGPIYAEDGD	CDHR5	266	Q9HBB8
LGPQLYGVFPEGRLE	CHKB	131	Q9Y259
FPPYVLRPDDGGPRV	DICER1	611	Q9UPY3
LPDFPLEGNPLFGRY	CLIP4	6	Q8N3C7
GRQVYPDVEPGYLRP	DDC	26	P20711
GIIPPRPAYEVFGSV	DMRTA2	146	Q96SC8
ISVYLFPGERSGAPP	ATG2A	1311	Q2TAZ0
PGPIVVRDGYFSRPI	ATG2A	1386	Q2TAZ0
PDDGVRGSPPEDYRL	RBM34	21	P42696
EAPGFFLDLEPIPGA	NT5C	66	Q8TCD5
PYLPPLGAGLGTVDE	RASA1	141	P20936
TAAIVPPGPEAGLIY	QKI	271	Q96PU8
LRSYVAGAPGAPEPE	RAB42	26	Q8N4Z0
GYDARIRPNFKGPPV	GLRA3	56	O75311
VFPAEGLIPPYGLTA	OLFML3	256	Q9NRN5
DGFNVRVPLPGPLFD	INPP4A	766	Q96PE3
GLRPPGFDPYLQFLR	NUP205	726	Q92621
LQRLGPGPALPEAFY	NPAS1	556	Q99742
LDGRGRPLPEPYEAS	LLGL1	796	Q15334
PPGGLTYFPVADLSI	MEN1	71	O00255
FAPIPFGGIYLPLEV	OTUD7B	326	Q6GQQ9
IPAVRGDIPPGCAAY	HCFC1	71	P51610
PDPTGPGLDREQLYL	MUC16	13866	Q8WXI7
FTLPVPGFEGYREPL	NFATC2	151	Q13469
PGFEGYREPLCLSPA	NFATC2	156	Q13469
RIPGFPRYRLEGDPA	NPHS1	76	O60500
YVAFLPESRPLEGPL	DCHS1	2176	Q96JQ0
GDVPDLFGAAPRYPL	IL17RA	511	Q96F46
PDLPDYDRRPLGFGS	LRCH3	281	Q96II8
LGPRYAVFPKDQRGP	KMT2C	2451	Q8NEZ4
DRPLGKDGRAAVPYP	MED13L	841	Q71F56
QVYLPGRGPPLREGE	GRWD1	31	Q9BQ67
YVYSGPEGRQLIAPP	ERVS71-1	416	P61550
GCTPDPRIVPFRGDY	L2HGDH	271	Q9H9P8
APKLGPGRPRYSFLD	SLC2A10	206	O95528
PFYIEDILGRGPAAP	HHEX	31	Q03014
DGFALGRAPLAPPYA	LMTK3	26	Q96Q04
PRVPSAGADGPLALY	BSN	1616	Q9UPA5
GIDRPPYGVFTINPR	DSG4	91	Q86SJ6
AAPAPLLPVYELDGA	GGT7	456	Q9UJ14
LYGPEGLELVRFPPA	IRF8	241	Q02556
PAVFVLPGIPGLEAY	OR52B2	11	Q96RD2
PRVLYPALGPDGSAL	PCDHGB1	556	Q9Y5G3
PVPDSRGGFYLLPVN	PDZD7	666	Q9H5P4
AFIDPLGLPDRPFYR	FOLH1B	366	Q9HBA9
PPGKYPNGFRDVLRE	SLC25A20	241	O43772
YPGIVDGPAALASFP	MEIS3	11	Q99687
GYDIRLRPDFGGPPV	GABRB2	46	P47870
GSPEELLQIPGPFYF	ABCC2	1516	Q92887
AGRAGLVVPPLALPY	FOXC2	291	Q99958
GLFEPPPAVVGNLLY	FAM181B	306	A6NEQ2
LGVPYAAPPTGERRF	NLGN1	81	Q8N2Q7
LDIEPDRPIGYGAFG	NLK	136	Q9UBE8
PRVLYPALGPDGSAL	PCDHGB5	556	Q9Y5G0
GNYFDLPRIRLPPGI	HECTD4	861	Q9Y4D8
GAVGPPDALRPAKYL	OLIG1	206	Q8TAK6
SLPSLEEYEPRGPGR	HELZ	1741	P42694
YAGPEAAAPGLPELR	NKX2-5	56	P52952
VRDLPPTPAGEGYAV	NKD2	411	Q969F2
DRGFGGPYCVPVVPL	RELN	1786	P78509
YEEGPGPGPLAEVRD	FOSB	226	P53539
LGYIDLPPPRLGENG	PATZ1	321	Q9HBE1
PDQLRGDAYIPGGPL	OVOL3	21	O00110
GVPYAAPPIGEKRFL	NLGN3	71	Q9NZ94
IFSLGVNPYPGIPVD	FLT3	881	P36888
DSGILFRDPYFPAGP	CAPN12	41	Q6ZSI9
LFYAPAAGGPEELVP	COL12A1	1876	Q99715
TPLYDQGGPVEILPF	DUSP1	166	P28562
LGGSPYPGVPVEELF	FGFR1	696	P11362
PGIIGGEYDQRPTLP	FBXO7	441	Q9Y3I1
TPEYEELCPRGPGFA	FBN1	1001	P35555
RAIDFSPYLEPLGAP	CEBPB	71	P17676
DAYPPGVLPGVASVL	BCL9L	1291	Q86UU0
GALTRPPYCLEAGEP	BLOC1S6	11	Q9UL45
CGPPDDLPSGRVEYI	MASP2	366	O00187
RLFPGPPEAEFGYSV	ITGA10	31	O75578
YGPERPGLPLAFAPA	FOXL1	21	Q12952
GVPFILEPGEYPDLS	CRYBG1	1176	Q9Y4K1
TFPSGIIGRIPAYDP	CELSR3	1186	Q9NYQ7
DFSLVAPGLPPGRLY	HELZ2	206	Q9BYK8
DRLVELLVFYGPPFP	DLEC1	1301	Q9Y238
RPAYDQGGPVEILPF	DUSP5	171	Q16690
GLPYPFPDGILDVIL	METTL8	261	Q9H825
PGLPTRPCFYDIDLD	MTHFD1	911	P11586
LGRPATAYGFRPDEP	KIFAP3	771	Q92845
PLAPGEFDPNIDVYG	PIP4K2A	326	P48426
PPEEPNGLVRGYRVY	PTPRF	436	P10586
DGSPVFYLLGIPSLP	OR2AT4	11	A6NND4
PGPIYFLDPKVTRFG	ODF3L2	86	Q3SX64
GVPDVANYRLFPGEP	MMP20	101	O60882
YPLPEEAGEGRANGP	NYAP1	266	Q6ZVC0
PGICYFLEVRTGPKP	GUCY1A2	691	P33402
LGTEPDPALYLPARG	FREM3	36	P0C091
LEGADLPNLLFYGPP	RFC4	66	P35249
FRPVPLPSGEEGEYV	POLR3GL	46	Q9BT43
RDALPEGDASPLGPY	SEZ6L	31	Q9BYH1
PGPGYAPLREEAVRL	PLEKHH3	256	Q7Z736
LREPEHFLYGGDPPL	PRUNE2	2366	Q8WUY3
PPGEDGRVEPYVDFA	TAB1	471	Q15750
PPGDPGDKYSAFREL	SYNRG	531	Q9UMZ2
PFRPLGSLGPREYFI	MIA3	1841	Q5JRA6
AFGLDRLPLPVSGFP	LMBR1L	466	Q6UX01
GEDDNPPCPRLYGVL	NBPF15	581	Q8N660
PFYCGLIPPEFRGER	PNPLA5	151	Q7Z6Z6
PAPPIGGALLFALRY	PPP1R3E	226	Q9H7J1
GYDARIRPNFKGPPV	GLRA1	51	P23415
GVGPTRLYPAAADPL	PRDM8	531	Q9NQV8
GLPPGPVLEARYVAR	SLC39A4	81	Q6P5W5
LDPSEAGPPRYLGDR	SLAMF1	81	Q13291
ELVYARGDGPGAPRP	KIAA1217	286	Q5T5P2
GPDGSAVPIYVPFLI	SHISA2	106	Q6UWI4
PAGPRPLDGYLGVAD	ST6GALNAC5	71	Q9BVH7
DPDFTYLGGILNPIP	NETO2	161	Q8NC67
PLGPEVDFSQGYELP	SP6	56	Q3SY56
PEEGAVRLRPAGEPY	PRR12	1926	Q9ULL5
PIELLPLGYSEPAFG	MLXIPL	471	Q9NP71
PAPYLEEAAPGQGRE	NOXO1	216	Q8NFA2
LGRFALDFGLVPAPP	L3HYPDH	111	Q96EM0
PIRPIGIFSGYVENP	ACSM2B	416	Q68CK6
GPPSSRAAPELLEYG	CLCN2	51	P51788
YPPAFPLGADIQGLD	PIAS3	516	Q9Y6X2
RGLRVCEDGPVFYPP	RNASET2	236	O00584
PVVPRGGFDSPFYRD	TSC1	496	Q92574
EATDRFLPEGYPLPL	RAPGEF1	51	Q13905
YEPGAALGPLPYPER	SHANK3	871	Q9BYB0
GGSDLPLRFPYGRPE	PPM1H	31	Q9ULR3
PLRFPYGRPEFLGLS	PPM1H	36	Q9ULR3
SIPPYPIAGGVDDLD	STIM2	471	Q9P246
EDQPLLYPPGFDGRV	THG1L	146	Q9NWX6
LYPPGFDGRVVVYPS	THG1L	151	Q9NWX6
ILIPVPAPAGGDDDY	YY1	131	P25490
RPLYVLNEEGGPAPV	VPS18	191	Q9P253
GDLDPPVGFQLYPEI	ZNF747	311	Q9BV97
IRPGESFITPYLLGP	SLC19A1	41	P41440
SPPGEGAPLAADVYV	MTHFSD	296	Q2M296
NERSYPEGFGLEPKP	WDFY4	2071	Q6ZS81
PFIYGDIPQGLVAVP	SCN8A	66	Q9UQD0
DLLGVLPPGTYPSDF	UNC5B	501	Q8IZJ1
GDPLLGPPDIRGRAY	SLC35G6	91	P0C7Q6
ADTPGLPKIYAREGP	ZBTB47	146	Q9UFB7
YPGNPCPGDLIEVFR	PLAAT1	11	Q9HDD0
IYDTIGLPDPPSLGF	PLEKHG1	741	Q9ULL1
GAEGEYALRLPRIPP	PLAAT5	6	Q96KN8
RAPAPLYVGPGVSEF	WDR25	206	Q64LD2
GSLEFGLPIPLSYVP	UGT3A2	171	Q3SY77
GGYRPAEDKIFPVPE	ZBED1	511	O96006
LSGLPAPDFIDYPER	MID2	701	Q9UJV3
FPYPLLPNVDFVGGL	UGT2B7	266	P16662
LYDPEKGARSLAGPP	PJA1	151	Q8NG27
FSPYREGPIRGPCAL	PRR23C	186	Q6ZRP0
RVYVLLPLLPGFEGD	PLD2	676	O14939
SPDGGYIPRILFLDP	TXNDC12	106	O95881
YYGNRGEPDPIVLTP	TANGO2	136	Q6ICL3
LYGRAEPPFAPRSGD	ZIC5	296	Q96T25
PEGVVLPAPYYGNRI	MXRA5	2481	Q9NR99
GYSFFPGEEEVLIPP	ART1	231	P52961