Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainEGF_3

ADAM21 FBN2 GP2

2.89e-03235233PS50026
DomainEGF-like_dom

ADAM21 FBN2 GP2

3.40e-03249233IPR000742
DomainEGF_1

ADAM21 FBN2 GP2

3.64e-03255233PS00022
DomainEGF-like_CS

ADAM21 FBN2 GP2

3.88e-03261233IPR013032
DomainEGF_2

ADAM21 FBN2 GP2

4.05e-03265233PS01186
DomainTRYPSIN_SER

TMPRSS12 TMPRSS9

5.44e-0390232IPR033116
DomainTRYPSIN_HIS

TMPRSS12 TMPRSS9

7.07e-03103232IPR018114
DomainTRYPSIN_SER

TMPRSS12 TMPRSS9

7.47e-03106232PS00135
DomainTRYPSIN_HIS

TMPRSS12 TMPRSS9

7.61e-03107232PS00134
DomainPeptidase_S1A

TMPRSS12 TMPRSS9

8.45e-03113232IPR001314
DomainTRYPSIN_DOM

TMPRSS12 TMPRSS9

8.74e-03115232PS50240
DomainTryp_SPc

TMPRSS12 TMPRSS9

9.03e-03117232SM00020
DomainTrypsin

TMPRSS12 TMPRSS9

9.64e-03121232PF00089
DomainTrypsin_dom

TMPRSS12 TMPRSS9

9.64e-03121232IPR001254
DomainPeptidase_S1_PA

TMPRSS12 TMPRSS9

9.94e-03123232IPR009003
PathwayREACTOME_KERATAN_SULFATE_BIOSYNTHESIS

ACAN B3GNT3

6.37e-0428192M670
PathwayREACTOME_KERATAN_SULFATE_BIOSYNTHESIS

ACAN B3GNT3

6.37e-0428192MM14798
PathwayREACTOME_KERATAN_SULFATE_KERATIN_METABOLISM

ACAN B3GNT3

1.06e-0336192M690
PathwayREACTOME_KERATAN_SULFATE_KERATIN_METABOLISM

ACAN B3GNT3

1.06e-0336192MM14632
Pubmed

Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities.

ACAN FBN2

1.64e-05924215296947
Pubmed

Screening for premutation in the FMR1 gene in male patients suspected of spinocerebellar ataxia.

CACNA1A FMR1

2.05e-051024219235102
Pubmed

Genome-wide meta-analysis identifies new susceptibility loci for migraine.

TRMT9B NAXE FBN2

2.12e-057824323793025
Pubmed

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.

ACAN FBN2

6.94e-051824235503090
Pubmed

The Repeat Expansion Diseases: The dark side of DNA repair.

CACNA1A FMR1

1.14e-042324226002199
Pubmed

Adamts18 modulates the development of the aortic arch and common carotid artery.

ACAN FBN2

1.47e-042624234189436
Pubmed

Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.

ACAN FBN2

1.83e-042924221998595
Pubmed

Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis.

ACAN FBN2

3.50e-044024230578393
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

CACNA1A HNRNPL FBN2 B3GNT3

5.18e-0455224410737800
InteractionCACNB2 interactions

CACNA1A HNRNPL FMR1

2.59e-0623243int:CACNB2
InteractionTRMT9B interactions

TRMT9B HNRNPL

2.84e-057242int:TRMT9B
GeneFamilyProteases, serine

TMPRSS12 TMPRSS9

1.22e-0363152738
GeneFamilyRNA binding motif containing

HNRNPL RBMXL3

1.31e-02213152725
ToppCell18-Airway-Epithelial-Neuroendocrine|Airway / Age, Tissue, Lineage and Cell class

CACNA1A PRUNE2 SLC29A4 NAXE

2.51e-06189234144beb01b908f2cd0e04513fb84d817e0c3c124e
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|Fibroblasts / Location, Cell class and cell subclass

ACAN SLC29A4 FBN2

7.98e-051642339b4a6007abae992db871d9f6f731d5af724de30d
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRMT9B CACNA1A SLC29A4

8.13e-051652334b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1A TMPRSS12 SLC29A4

8.42e-05167233c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EECs|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRMT9B CACNA1A SLC29A4

9.03e-05171233dd37e1693a5cfc42e40992d504f92048a8038b52
ToppCellLV-13._Vascular_Smooth_Muscle|LV / Chamber and Cluster_Paper

CACNA1A PRUNE2 ACAN

9.03e-05171233e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRMT9B CACNA1A SLC29A4

9.35e-051732339a3500b06d00d1d4ee42910a3a73327b21beab52
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 FBN2 B3GNT3

9.84e-0517623333323c97afe509147956b8df9f92ca6b0537e604
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A PRUNE2 SLC29A4

1.02e-0417823330ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCelldroplet-Kidney-nan-21m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A PRUNE2 SLC29A4

1.03e-04179233b7281160c84dd053a2981c9c76ea6cc6d2592cd5
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRMT9B FBN2 B3GNT3

1.03e-0417923355bc69f107fc710db7617c428575792adfdbbcc1
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A PRUNE2 SLC29A4

1.03e-04179233f2e8fc975c30992611630197b79daaeef7c4211d
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A PRUNE2 SLC29A4

1.05e-041802339db9899ca42455310e9b63df523fe6c4780abfb7
ToppCell3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_mucus_secreting_cell-SMG_mucous-SMG_mucous_L.0.6.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYB5R2 B3GNT3 GP2

1.09e-041822336d7ba2e1f33aaa499a898ed9587197c0ee625e9a
ToppCellRA-13._Vascular_Smooth_Muscle|RA / Chamber and Cluster_Paper

TRMT9B CACNA1A PRUNE2

1.10e-04183233818fd886e0188091310825f9145fa53328f2c979
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRMT9B FBN2 B3GNT3

1.10e-0418323383592c332b1e82673f993d37c7f480befdc3dcda
ToppCellRA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

TRMT9B CACNA1A PRUNE2

1.10e-04183233cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell18-Distal-Epithelial-Neuroendocrine|Distal / Age, Tissue, Lineage and Cell class

CACNA1A PRUNE2 SLC29A4

1.14e-04185233f8fc7b12b4e18d23d84e95488be93c4352d325f3
ToppCell3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_mucus_secreting_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYB5R2 B3GNT3 GP2

1.14e-04185233d9039770226338fbc3fce92aa229fad96e16db8c
ToppCell3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_mucus_secreting_cell-SMG_mucous|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYB5R2 B3GNT3 GP2

1.14e-04185233b931ab35da10e6e3877071dce9b13fc0da63dc88
ToppCell5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMPRSS9 SLC29A4 GP2

1.16e-041862332fab7abed16a894afdd0207e86fc43a25a77fb9e
ToppCell5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMPRSS9 SLC29A4 GP2

1.16e-04186233ea2c8e0df038a00062d2098b4a9ac85141b9a728
ToppCell5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMPRSS9 SLC29A4 GP2

1.16e-04186233714765585a644bf9817ab6eb3001b43b3c2d2410
ToppCell15-Airway-Epithelial-Neuroendocrine|Airway / Age, Tissue, Lineage and Cell class

TRMT9B PRUNE2 SLC29A4

1.18e-04187233a7d2f30fe0f19e63d44603ece9890acd11b45e52
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1A SLC29A4 GP2

1.20e-041882331f912ea015f50570e848259d948a0ba682d64bb4
ToppCell21-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

CACNA1A PRUNE2 SLC29A4

1.20e-04188233e78d4f7a5d28c77503cb041ff585d13df4c88bd2
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1A SLC29A4 GP2

1.23e-0419023340d8b3403f4e38436b961cd3a2e69826cbae3042
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1A SLC29A4 GP2

1.23e-04190233f6cbf6d292f488ada5f7581e1dceba6198b933d1
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1A SLC29A4 GP2

1.23e-04190233a9a705455019e28d655636de73b07540798f82e6
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRMT9B PRUNE2 FBN2

1.23e-0419023359bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCellcellseq-Epithelial-Epithelial_Neuro-Secretory-PNEC-PNEC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SLC29A4 NAXE GP2

1.25e-04191233146cfd4daa2878536b4f381564c787919ad855a8
ToppCellcellseq-Epithelial-Epithelial_Neuro-Secretory-PNEC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SLC29A4 NAXE GP2

1.25e-0419123312ea07565dc0e62cade9fbab4a2d763e47a341e3
ToppCellcellseq-Epithelial-Epithelial_Neuro-Secretory|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SLC29A4 NAXE GP2

1.29e-0419323325b1e5a04724023918c8939109a92b35582d5e5c
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 FBN2 B3GNT3

1.31e-041942338ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Pulmonary_neuroendocrine|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CACNA1A PRUNE2 NAXE

1.31e-04194233ccff0b5814f5de2d42720018e7f5dc5dcdafb568
ToppCelldroplet-Limb_Muscle-MUSCLE-1m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACAN GORASP2 FBN2

1.33e-04195233fee9d13f48149cd5f921cfe4b8b3053cf6a6dbd2
ToppCell18-Airway|18 / Age, Tissue, Lineage and Cell class

ACAN LTB FBN2

1.39e-041982333cdfcc6445858c3c54058bbd90b20b88b1771cca
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Npnt_(Retrosplenial_areas,_layer_5,_Npnt+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

TMPRSS9 LTB

2.03e-0441232b1e70962de91a747ec718a3fad4247fd0cb7d9a8
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Npnt_(Retrosplenial_areas,_layer_5,_Npnt+)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

TMPRSS9 LTB

2.03e-044123216dbb13baa47c4db80ddd83ac36aad6c43b5461a
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Atp2b4-Inhibitory_Neuron.Gad1Gad2_Sst.Atp2b4_(Interneuron,_Olm)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

ADAM21 B3GNT3

2.55e-04462321259dca3ada3ba697ce50268163bd3b63e3c77bc
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Atp2b4|Hippocampus / BrainAtlas - Mouse McCarroll V32

ADAM21 B3GNT3

2.55e-0446232457e258b9b38e581b69ff92fc02d552c24d841cf
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Atp2b4-Inhibitory_Neuron.Gad1Gad2_Sst.Atp2b4_(Interneuron,_Olm)|Hippocampus / BrainAtlas - Mouse McCarroll V32

ADAM21 B3GNT3

2.55e-04462325c1cd6647dd412162273fa01a73f65d62d422038
DrugDoxazosin mesylate [77883-43-3]; Up 200; 7.4uM; MCF7; HT_HG-U133A

TRMT9B PRUNE2 ACAN GP2

3.99e-051942343363_UP
Drugestradiol; Down 200; 0.01uM; PC3; HT_HG-U133A

TRMT9B GAL3ST4 ACAN FBN2

4.07e-051952345910_DN
DrugFluvoxamine maleate [61718-82-9]; Up 200; 9.2uM; PC3; HT_HG-U133A

TRMT9B PRUNE2 ACAN ANGEL2

4.32e-051982343995_UP
Drug2-propylpentanoic acid; Up 200; 50uM; PC3; HT_HG-U133A

CACNA1A GAL3ST4 ANGEL2 GP2

4.32e-051982344446_UP
Diseasehearing loss

TMPRSS9 ACAN

1.25e-0367232EFO_0004238
Diseasemigraine disorder

TRMT9B CACNA1A FBN2

2.60e-03357233MONDO_0005277
Diseasesleep quality

FBN2 GP2

3.80e-03118232EFO_0005272

Protein segments in the cluster

PeptideGeneStartEntry
PPGPRHHGYYRGSDY

CACNA1A

2401

O00555
GWSPPYCQHRGYGGS

ADAM21

656

Q9UKJ8
PYRRGYLLYGPPGCG

BCS1L

221

Q9Y276
YGHCVVGRGRYPMFP

ANGEL2

11

Q5VTE6
RRQSGAHYGPFPGGF

ST13P5

271

Q8NFI4
FFRGPRGRLFYHGPG

CYB5R2

116

Q6BCY4
FTGRYHYLGGRFVPP

NAXE

251

Q8NCW5
GCGIGYGYLHRIPTR

GORASP2

191

Q9H8Y8
ACPGGYHVYRLEGTP

GP2

156

P55259
YPGPGGSYGFRLSCV

PDZD3

471

Q86UT5
NPRGFYRPGARGDHY

GAL3ST4

191

Q96RP7
GGVVFHYRPGPTRYS

ACAN

476

P16112
YRNRGHGRRGPGYTS

FMR1

476

Q06787
NERYPPYCGGGGFLL

B3GNT3

261

Q9Y2A9
GHRRGPSRYGPQYGH

HNRNPL

351

P14866
CPPGYYRVGQGHCVS

FBN2

2721

P35556
PYRRVISHGGYYGDG

PRUNE2

2901

Q8WUY3
FHGSGVGDPFGPRCY

SPRYD3

306

Q8NCJ5
HRYGGGGRYEEYRGP

RBMXL3

941

Q8N7X1
GYGCGRPHFPGVYTR

TMPRSS9

1031

Q7Z410
GITSYGHGCGRRGFP

TMPRSS12

286

Q86WS5
GRKRQCGYPERGHPY

TRMT9B

176

Q9P272
GRPGLGRGYGYRVHH

SLC29A4

271

Q7RTT9
GSPHRGPGCYFSDGY

PIFO

41

Q8TCI5
YCLVGYRGRAPPGGG

LTB

136

Q06643
GYILGIYRIPHGRGC

LIPK

56

Q5VXJ0