Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cholesterol O-acyltransferase activity	SOAT2 SOAT1	2.66e-05	3	60	2	GO:0034736
GeneOntologyMolecularFunction	sterol O-acyltransferase activity	SOAT2 SOAT1	2.66e-05	3	60	2	GO:0004772
GeneOntologyMolecularFunction	benzoate-CoA ligase activity	ACSM2A ACSM2B	2.66e-05	3	60	2	GO:0018858
GeneOntologyMolecularFunction	RNA transmembrane transporter activity	SIDT2 SIDT1	2.66e-05	3	60	2	GO:0051033
GeneOntologyMolecularFunction	nucleic acid transmembrane transporter activity	SIDT2 SIDT1	2.66e-05	3	60	2	GO:0051032
GeneOntologyMolecularFunction	tRNA (cytidine-3-)-methyltransferase activity	METTL2A METTL2B	5.31e-05	4	60	2	GO:0052735
GeneOntologyMolecularFunction	decanoate-CoA ligase activity	ACSM2A ACSM2B	5.31e-05	4	60	2	GO:0102391
GeneOntologyMolecularFunction	fatty-acyl-CoA synthase activity	ACSM2A ACSM2B	2.46e-04	8	60	2	GO:0004321
GeneOntologyMolecularFunction	alcohol binding	SIDT1 SOAT2 SOAT1 XPR1	2.51e-04	102	60	4	GO:0043178
GeneOntologyMolecularFunction	tRNA (cytidine) methyltransferase activity	METTL2A METTL2B	3.93e-04	10	60	2	GO:0016427
GeneOntologyMolecularFunction	medium-chain fatty acid-CoA ligase activity	ACSM2A ACSM2B	4.80e-04	11	60	2	GO:0031956
GeneOntologyMolecularFunction	steroid binding	CALB1 SIDT1 SOAT2 SOAT1	6.87e-04	133	60	4	GO:0005496
GeneOntologyMolecularFunction	cholesterol binding	SIDT1 SOAT2 SOAT1	7.08e-04	58	60	3	GO:0015485
GeneOntologyMolecularFunction	sterol binding	SIDT1 SOAT2 SOAT1	1.27e-03	71	60	3	GO:0032934
GeneOntologyMolecularFunction	vitamin binding	CALB1 AKR1B15 TTPA DDC	1.40e-03	161	60	4	GO:0019842
GeneOntologyMolecularFunction	C-acyltransferase activity	ACSM2A ACSM2B	1.80e-03	21	60	2	GO:0016408
GeneOntologyMolecularFunction	fatty-acyl-CoA binding	SOAT2 SOAT1	1.97e-03	22	60	2	GO:0000062
GeneOntologyMolecularFunction	fatty acid derivative binding	SOAT2 SOAT1	2.35e-03	24	60	2	GO:1901567
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSM2A ACSM2B	2.75e-03	26	60	2	GO:0015645
GeneOntologyMolecularFunction	acyl-CoA binding	SOAT2 SOAT1	2.75e-03	26	60	2	GO:0120227
GeneOntologyMolecularFunction	CoA-ligase activity	ACSM2A ACSM2B	2.97e-03	27	60	2	GO:0016405
GeneOntologyMolecularFunction	inward rectifier potassium channel activity	KCNJ4 KCNK6	3.19e-03	28	60	2	GO:0005242
GeneOntologyMolecularFunction	hexosyltransferase activity	LARGE2 B3GNT9 POFUT1 B3GNT3	3.72e-03	211	60	4	GO:0016758
GeneOntologyMolecularFunction	acid-thiol ligase activity	ACSM2A ACSM2B	3.90e-03	31	60	2	GO:0016878
GeneOntologyMolecularFunction	macromolecule transmembrane transporter activity	SIDT2 SIDT1	4.68e-03	34	60	2	GO:0022884
GeneOntologyMolecularFunction	tRNA methyltransferase activity	METTL2A METTL2B	4.68e-03	34	60	2	GO:0008175
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	ACSM2A SOAT2 SOAT1 ACSM2B	5.69e-03	238	60	4	GO:0016747
Domain	NECAP_PHear	NECAP2 NECAP1	9.48e-06	2	58	2	IPR012466
Domain	SID1_TM_fam	SIDT2 SIDT1	9.48e-06	2	58	2	IPR025958
Domain	SID-1_RNA_chan	SIDT2 SIDT1	9.48e-06	2	58	2	PF13965
Domain	Sterol_acyltranf_meta	SOAT2 SOAT1	9.48e-06	2	58	2	IPR030687
Domain	DUF1681	NECAP2 NECAP1	9.48e-06	2	58	2	PF07933
Domain	Oat_ACAT_DAG_ARE	SOAT2 SOAT1	2.84e-05	3	58	2	IPR014371
Domain	MeTrfase	METTL2A METTL2B	5.66e-05	4	58	2	IPR026113
Domain	TDE1/TMS	SERINC1 SERINC3	9.42e-05	5	58	2	IPR005016
Domain	Serinc	SERINC1 SERINC3	9.42e-05	5	58	2	PF03348
Domain	Methyltransf_12	METTL2A METTL2B	1.41e-04	6	58	2	PF08242
Domain	Methyltransf_12	METTL2A METTL2B	1.41e-04	6	58	2	IPR013217
Domain	MBOAT_fam	SOAT2 SOAT1	5.12e-04	11	58	2	IPR004299
Domain	MBOAT	SOAT2 SOAT1	5.12e-04	11	58	2	PF03062
Domain	Glyco_trans_31	B3GNT9 B3GNT3	1.11e-03	16	58	2	IPR002659
Domain	Galactosyl_T	B3GNT9 B3GNT3	1.11e-03	16	58	2	PF01762
Domain	AMP-bd_C	ACSM2A ACSM2B	1.25e-03	17	58	2	IPR025110
Domain	AMP-binding_C	ACSM2A ACSM2B	1.25e-03	17	58	2	PF13193
Domain	PH_dom-like	NECAP2 NBEAL2 ALS2 CDC42BPB RASAL2 NECAP1	2.02e-03	426	58	6	IPR011993
Domain	AMP-binding_CS	ACSM2A ACSM2B	2.94e-03	26	58	2	IPR020845
Domain	AMP_BINDING	ACSM2A ACSM2B	3.40e-03	28	58	2	PS00455
Domain	AMP-binding	ACSM2A ACSM2B	3.90e-03	30	58	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSM2A ACSM2B	3.90e-03	30	58	2	IPR000873
Pathway	REACTOME_CONJUGATION_OF_SALICYLATE_WITH_GLYCINE	ACSM2A ACSM2B	1.29e-04	6	42	2	MM14693
Pathway	REACTOME_AMINO_ACID_CONJUGATION	ACSM2A ACSM2B	1.80e-04	7	42	2	MM14598
Pathway	KEGG_TYROSINE_METABOLISM	TYR DDC METTL2B	2.60e-04	42	42	3	M16743
Pathway	REACTOME_SERINE_BIOSYNTHESIS	SERINC1 SERINC3	3.08e-04	9	42	2	M27959
Pathway	REACTOME_SERINE_BIOSYNTHESIS	SERINC1 SERINC3	3.08e-04	9	42	2	MM15707
Pathway	REACTOME_AMINO_ACID_CONJUGATION	ACSM2A ACSM2B	3.08e-04	9	42	2	M26968
Pathway	WP_DOPAMINE_METABOLISM	TYR DDC	6.62e-04	13	42	2	M39622
Pathway	WP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES	NECAP2 SERINC1 HEATR5A SOAT2 SOAT1 NECAP1	8.63e-04	381	42	6	M48063
Pathway	KEGG_STEROID_BIOSYNTHESIS	SOAT2 SOAT1	1.15e-03	17	42	2	M5872
Pathway	REACTOME_LDL_CLEARANCE	SOAT2 SOAT1	1.29e-03	18	42	2	MM15565
Pathway	REACTOME_LDL_CLEARANCE	SOAT2 SOAT1	1.43e-03	19	42	2	M27846
Pathway	REACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL	KCNJ4 KCNK6	1.43e-03	19	42	2	M27452
Pathway	REACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL	KCNJ4 KCNK6	1.43e-03	19	42	2	MM15194
Pubmed	Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.	ACSM2A ACSM2B	2.93e-06	2	60	2	19634011
Pubmed	The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.	ACSM2A ACSM2B	2.93e-06	2	60	2	16521160
Pubmed	Expression of two isozymes of acyl-coenzyme A: cholesterol acyltransferase-1 and -2 in clear cell type renal cell carcinoma.	SOAT2 SOAT1	2.93e-06	2	60	2	18269457
Pubmed	Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies.	SOAT2 SOAT1	2.93e-06	2	60	2	15992359
Pubmed	Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine.	SOAT2 SOAT1	2.93e-06	2	60	2	22811412
Pubmed	A novel family of mammalian transmembrane proteins involved in cholesterol transport.	SIDT2 SIDT1	2.93e-06	2	60	2	28785058
Pubmed	Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism.	SOAT2 SOAT1	2.93e-06	2	60	2	26982734
Pubmed	Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.	ACSM2A ACSM2B	2.93e-06	2	60	2	29948332
Pubmed	Quantitative analysis of the expression of ACAT genes in human tissues by real-time PCR.	SOAT2 SOAT1	2.93e-06	2	60	2	14729857
Pubmed	A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2.	SOAT2 SOAT1	2.93e-06	2	60	2	16647063
Pubmed	Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1.	SIDT2 SIDT1	2.93e-06	2	60	2	26067272
Pubmed	Identification of a ubiquitous family of membrane proteins and their expression in mouse brain.	SERINC1 SERINC3	2.93e-06	2	60	2	10637174
Pubmed	Organization of human ACAT-2 gene and its cell-type-specific promoter activity.	SOAT2 SOAT1	2.93e-06	2	60	2	11401500
Pubmed	Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT).	SOAT2 SOAT1	2.93e-06	2	60	2	18000807
Pubmed	The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (-77G-->A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects.	SOAT2 SOAT1	2.93e-06	2	60	2	15158756
Pubmed	Ability of serum to decrease cellular acylCoA:cholesterol acyl transferase activity predicts cardiovascular outcomes.	SOAT2 SOAT1	2.93e-06	2	60	2	16230498
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	B3GNT9 B3GNT3 KLHL8 CHI3L2 METTL2A MMP14 ACSM2A CDC42BPB METTL2B	4.28e-06	730	60	9	34857952
Pubmed	Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes.	SOAT2 SOAT1	8.77e-06	3	60	2	9756920
Pubmed	Dysregulated expression of sterol O-acyltransferase 1 (Soat1) in the hair shaft of Hoxc13 null mice.	TYR SOAT1	8.77e-06	3	60	2	26321246
Pubmed	DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification.	METTL2A METTL2B	8.77e-06	3	60	2	32427860
Pubmed	Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6.	METTL2A METTL2B	1.75e-05	4	60	2	34268557
Pubmed	ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.	SOAT2 SOAT1	1.75e-05	4	60	2	20133765
Pubmed	Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells.	SOAT2 SOAT1	1.75e-05	4	60	2	15308631
Pubmed	ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation.	SOAT2 SOAT1	1.75e-05	4	60	2	22669916
Pubmed	Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.	ACSM2A ACSM2B	1.75e-05	4	60	2	32830538
Pubmed	Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins.	METTL2A METTL2B	1.75e-05	4	60	2	11738826
Pubmed	Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif.	NECAP2 NECAP1	1.75e-05	4	60	2	14555962
Pubmed	Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase.	SOAT2 SOAT1	1.75e-05	4	60	2	22474282
Pubmed	Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans.	METTL2A METTL2B	2.92e-05	5	60	2	28655767
Pubmed	Generation of Cre transgenic mice with postnatal RPE-specific ocular expression.	TYR HEPH	2.92e-05	5	60	2	21212186
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ALS2 POFUT1 KLHL8 CDC42BPB HEPH	4.43e-05	225	60	5	12168954
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	B3GNT9 SIDT2 SERINC1 KRTDAP NBEAL2 B3GNT3 CLEC19A HEPH METTL2B	4.57e-05	985	60	9	12975309
Pubmed	ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization.	SOAT2 SOAT1	8.14e-05	8	60	2	9756919
Pubmed	Definition of the consensus motif recognized by gamma-adaptin ear domains.	NECAP2 NECAP1	1.05e-04	9	60	2	14665628
Pubmed	Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2.	CALB1 DDC	2.26e-04	13	60	2	16396906
Pubmed	Association study of the serotoninergic system in migraine in the Spanish population.	HTR1B DDC	4.40e-04	18	60	2	19455600
Pubmed	Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.	CALB1 METTL2A METTL2B	4.51e-04	86	60	3	19501082
Pubmed	Unravelling the complex genetics of cleft lip in the mouse model.	METTL2A METTL2B	4.91e-04	19	60	2	11353389
Pubmed	Pet-1 is required across different stages of life to regulate serotonergic function.	HTR1B DDC	5.45e-04	20	60	2	20818386
Pubmed	Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.	CALB1 DDC	5.45e-04	20	60	2	23637192
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NDST1 SUGP2 NBEAL2 RAPGEF1 DEPDC5 POFUT1 MMP14 CDC42BPB	5.99e-04	1105	60	8	35748872
Pubmed	Subtype specification of GABAergic amacrine cells by the orphan nuclear receptor Nr4a2/Nurr1.	CALB1 DDC	6.02e-04	21	60	2	19692620
Pubmed	Worldwide genetic variation in dopamine and serotonin pathway genes: implications for association studies.	HTR1B DDC	6.02e-04	21	60	2	18270970
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SUGP2 ALS2 HEATR5A ADGRL3 EPM2AIP1	6.90e-04	407	60	5	12693553
Pubmed	Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development.	TYR CALB1	7.23e-04	23	60	2	21937600
Pubmed	Fibroblast growth factor 2 regulates dopaminergic neuron development in vivo.	CALB1 DDC	7.88e-04	24	60	2	22537018
Pubmed	TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.	CALB1 KCNJ4	7.88e-04	24	60	2	24487590
Pubmed	Holoprosencephaly Overview	STIL STAG2	8.56e-04	25	60	2	20301702
Pubmed	Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.	ACSM2A ACSM2B	8.56e-04	25	60	2	19372376
Pubmed	Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions.	CALB1 CDC42BPB	1.07e-03	28	60	2	35942939
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	NECAP2 RAPGEF1 USP9Y NECAP1	1.17e-03	266	60	4	19380743
Pubmed	Activation of Wnt signaling reduces ipsilaterally projecting retinal ganglion cells in pigmented retina.	TYR CALB1	1.32e-03	31	60	2	30254141
Pubmed	Genetic associations of brain structural networks in schizophrenia: a preliminary study.	CLSTN2 DDC	1.32e-03	31	60	2	20691427
Pubmed	Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis.	CALB1 MMP14	1.32e-03	31	60	2	19898483
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	CCDC180 CDC42BPB STAG2	1.43e-03	128	60	3	23858473
Pubmed	Convergence of the insulin and serotonin programs in the pancreatic β-cell.	HTR1B DDC	1.58e-03	34	60	2	22013016
Pubmed	5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival.	HTR1B DDC	1.68e-03	35	60	2	28031476
Cytoband	16p12.3	CLEC19A ACSM2A ACSM2B	1.23e-05	34	60	3	16p12.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1q25	RASAL2 SOAT1 XPR1	1.39e-03	167	60	3	chr1q25
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	CLEC19A ACSM2A ACSM2B	1.51e-03	172	60	3	chr16p12
GeneFamily	Beta 3-glycosyltransferases	B3GNT9 B3GNT3	9.23e-04	24	34	2	426
GeneFamily	Acyl-CoA synthetase family	ACSM2A ACSM2B	1.08e-03	26	34	2	40
GeneFamily	Methyltransferase like	METTL2A METTL2B	1.75e-03	33	34	2	963
GeneFamily	Ubiquitin specific peptidases	USP53 USP9Y	4.96e-03	56	34	2	366
Coexpression	SANSOM_APC_TARGETS_REQUIRE_MYC	NBEAL2 SIDT1 SHPRH POFUT1 METTL2A METTL2B	1.48e-05	231	60	6	MM737
Coexpression	GSE10211_UV_INACT_SENDAI_VS_LIVE_SENDAI_VIRUS_TRACHEAL_EPITHELIAL_CELLS_UP	USP53 TTC7B SIDT1 HEATR5A EPM2AIP1	2.59e-05	152	60	5	M343
Coexpression	GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP	TTC7B NBEAL2 RAPGEF1 KCNK6 SOAT2	5.08e-05	175	60	5	M6690
Coexpression	GSE35825_UNTREATED_VS_IFNG_STIM_MACROPHAGE_DN	NDST1 NBEAL2 DEPDC5 SOAT1 XPR1	5.97e-05	181	60	5	M8662
Coexpression	GSE3982_BASOPHIL_VS_TH1_UP	IQCH SERINC1 SERINC3 HBZ STAG2	9.34e-05	199	60	5	M5564
Coexpression	GSE7460_CD8_TCELL_VS_CD4_TCELL_ACT_UP	NBEAL2 SIDT1 ALS2 DDC SOAT2	9.34e-05	199	60	5	M5687
Coexpression	GSE41867_NAIVE_VS_DAY15_LCMV_EFFECTOR_CD8_TCELL_DN	NDST1 SIDT2 CDC42BPB STAG2 NECAP1	9.56e-05	200	60	5	M9472
Coexpression	GSE2770_UNTREATED_VS_IL12_TREATED_ACT_CD4_TCELL_48H_UP	RAPGEF1 HEATR5A STIL STAG2 RASAL2	9.56e-05	200	60	5	M6044
Coexpression	GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_UP	NDST1 NECAP2 SERINC3 KCNK6 DDC	9.56e-05	200	60	5	M6947
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_500	USP53 ETNK2 AKR1B15 SERINC3 DEPDC5 MMP14 HBZ SOAT1	1.70e-05	403	60	8	gudmap_developingGonad_e12.5_epididymis_500
CoexpressionAtlas	dev gonad_e11.5_F_SupCellPrec_Sry_k-means-cluster#2_top-relative-expression-ranked_100	CALB1 ADGRL3 SOAT1	2.01e-05	19	60	3	gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_k2_100
CoexpressionAtlas	dev gonad_e11.5_F_GonMes_Sma_k-means-cluster#3_top-relative-expression-ranked_100	CALB1 ADGRL3 SOAT1	3.65e-05	23	60	3	gudmap_dev gonad_e11.5_F_GonMes_Sma_k3_100
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#1_top-relative-expression-ranked_100	CALB1 ADGRL3 SOAT1	4.72e-05	25	60	3	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k1_100
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_1000	USP53 CALB1 DDX25 SHPRH SERINC3 DEPDC5 HBZ RASAL2 SOAT1 EPM2AIP1	5.78e-05	776	60	10	gudmap_developingGonad_e14.5_ ovary_1000
CoexpressionAtlas	DevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000	USP53 B3GNT9 CALB1 SHPRH SERINC3 DEPDC5 MMP14 RASAL2 SOAT1 EPM2AIP1	7.07e-05	795	60	10	gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_top-relative-expression-ranked_1000	USP53 CALB1 SHPRH SERINC3 DEPDC5 MMP14 HBZ RASAL2 SOAT1 EPM2AIP1	7.76e-05	804	60	10	gudmap_developingGonad_e12.5_ovary_1000
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000	USP53 ETNK2 AKR1B15 SERINC3 DEPDC5 MMP14 HBZ RASAL2 SOAT1 EPM2AIP1	7.92e-05	806	60	10	gudmap_developingGonad_e12.5_epididymis_1000
CoexpressionAtlas	DevelopingGonad_e14.5_ testes_emap-6710_top-relative-expression-ranked_200	DDX25 SERINC3 MMP14 HBZ RASAL2	8.66e-05	159	60	5	gudmap_developingGonad_e14.5_ testes_200
CoexpressionAtlas	dev gonad_e11.5_F_SupCellPrec_Sry_k-means-cluster#3_top-relative-expression-ranked_200	CALB1 ADGRL3 SOAT1	9.11e-05	31	60	3	gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_k3_200
CoexpressionAtlas	DevelopingGonad_e14.5_ testes_emap-6710_top-relative-expression-ranked_500	DDX25 AKR1B15 SERINC3 USP9Y MMP14 HBZ RASAL2	1.54e-04	411	60	7	gudmap_developingGonad_e14.5_ testes_500
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#2_top-relative-expression-ranked_200	CALB1 ADGRL3 SOAT1	2.62e-04	44	60	3	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k2_200
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#3_top-relative-expression-ranked_500	ETNK2 AKR1B15 SERINC3 MMP14	3.05e-04	114	60	4	gudmap_developingGonad_e12.5_epididymis_k3_500
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TICRR B3GNT3 STIL TRAM2 CDC42BPB	4.68e-06	182	60	5	39f9b3eb22293cc27c6e175702c77d1eeb24fdc9
Drug	cyclandelate	HTR1B SOAT2 SOAT1	2.83e-06	11	60	3	CID000002893
Drug	DMPH4	TYR HTR1B DDC	2.83e-06	11	60	3	CID000073578
Drug	AC1Q6A3R	SOAT2 SOAT1	6.83e-06	2	60	2	CID000160583
Drug	gypsetin	SOAT2 SOAT1	6.83e-06	2	60	2	CID000160406
Drug	glisoprenin B	SOAT2 SOAT1	6.83e-06	2	60	2	CID006438769
Drug	NSC292654	SOAT2 SOAT1	6.83e-06	2	60	2	CID000325064
Drug	23-methyl-UDCA	SOAT2 SOAT1	6.83e-06	2	60	2	CID000196679
Drug	7,7-difluorocholestanol	SOAT2 SOAT1	6.83e-06	2	60	2	CID000196646
Drug	6,6-difluorocholestanol	SOAT2 SOAT1	6.83e-06	2	60	2	CID000196647
Drug	Aplus	SOAT2 SOAT1	6.83e-06	2	60	2	CID000028221
Drug	Ro 16-0521	SOAT2 SOAT1	6.83e-06	2	60	2	CID000065657
Drug	AC1NT076	SOAT2 SOAT1	6.83e-06	2	60	2	CID005321102
Drug	xymedon	SOAT2 SOAT1	6.83e-06	2	60	2	CID000121931
Drug	L-DOPA methyl ester	TYR HTR1B DDC	9.51e-06	16	60	3	CID000023497
Drug	Sulfaquinoxaline sodium salt [967-80-6]; Up 200; 12.4uM; HL60; HT_HG-U133A	NDST1 SIDT2 HTR1B CLSTN2 POFUT1 HEPH	1.28e-05	196	60	6	2528_UP
Drug	olean-12-ene	SOAT2 SOAT1	2.05e-05	3	60	2	CID000612780
Drug	Purpactin A	SOAT2 SOAT1	2.05e-05	3	60	2	CID000131673
Drug	glisoprenin A	SOAT2 SOAT1	2.05e-05	3	60	2	CID006438768
Drug	Nsc692258	SOAT2 SOAT1	2.05e-05	3	60	2	CID000469167
Drug	ethyl 6-chlorochroman-2-carboxylate	SOAT2 SOAT1	2.05e-05	3	60	2	CID000169516
Drug	zaragozic acid D3	SOAT2 SOAT1	2.05e-05	3	60	2	CID006475792
Drug	2-S-cysteinyldopa	TYR DDC	2.05e-05	3	60	2	CID000160007
Drug	5-OH-dopa	TYR DDC	2.05e-05	3	60	2	CID000161161
Drug	AC1NUTWC	ACSM2A ACSM2B	4.08e-05	4	60	2	CID005460914
Drug	Cgs-26214	SOAT2 SOAT1	4.08e-05	4	60	2	CID000133077
Drug	AC1L3QAA	SOAT2 SOAT1	4.08e-05	4	60	2	CID000093484
Drug	isochromophilone VII	SOAT2 SOAT1	4.08e-05	4	60	2	CID006443571
Drug	isochromophilone VIII	SOAT2 SOAT1	4.08e-05	4	60	2	CID006443572
Drug	Metergoline	HTR1B DDC	4.08e-05	4	60	2	ctd:D008711
Drug	acaterin	SOAT2 SOAT1	4.08e-05	4	60	2	CID000126830
Drug	acetic acids	TYR ACSM2A ACSM2B	5.44e-05	28	60	3	CID000031229
Drug	AC1L2WGH	TYR DDC	6.79e-05	5	60	2	CID000129916
Drug	v La	TYR DDC	6.79e-05	5	60	2	CID000160637
Drug	8-hydroxygenistein	TYR DDC	6.79e-05	5	60	2	CID005492944
Drug	N-beta-alanyldopamine	TYR DDC	6.79e-05	5	60	2	CID000162755
Drug	NSC-110264	SOAT2 SOAT1	6.79e-05	5	60	2	CID000269324
Drug	aminoparathion	TYR SERINC3	1.02e-04	6	60	2	CID000000220
Drug	butyl butyrate	CALB1 XPR1	1.02e-04	6	60	2	CID000007983
Drug	SCH 48461	SOAT2 SOAT1	1.02e-04	6	60	2	CID000132832
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A_EA	SERINC1 INPP5B SIDT1 SERINC3 POFUT1	1.15e-04	181	60	5	1077_UP
Drug	Equilin [474-86-2]; Up 200; 15uM; MCF7; HT_HG-U133A	NDST1 HTR1B DEPDC5 POFUT1 TTPA	1.52e-04	192	60	5	5620_UP
Drug	Graveoline [485-61-0]; Up 200; 14.4uM; PC3; HT_HG-U133A	USP53 B3GNT3 CHI3L2 ADGRL3 RASAL2	1.56e-04	193	60	5	4276_UP
Drug	alpha-Santonin [481-06-1]; Up 200; 16.2uM; PC3; HT_HG-U133A	SIDT2 B3GNT3 MMP14 ADGRL3 SOAT1	1.59e-04	194	60	5	4531_UP
Drug	haloperidol; Up 200; 10uM; MCF7; HT_HG-U133A	TMEM62 INPP5B POFUT1 B3GNT3 RASAL2	1.59e-04	194	60	5	1628_UP
Drug	Pilocarpine nitrate [148-72-1]; Up 200; 14.8uM; MCF7; HT_HG-U133A	TMEM62 ETNK2 CLSTN2 POFUT1 RASAL2	1.67e-04	196	60	5	5341_UP
Drug	(+/-)-blebbistatin; Down 200; 17uM; MCF7; HT_HG-U133A_EA	PIGN NDST1 NECAP2 POFUT1 TRAM2	1.67e-04	196	60	5	837_DN
Drug	Triprolidine hydrochloride [550-70-9]; Up 200; 12.8uM; MCF7; HT_HG-U133A	TMEM62 INPP5B B3GNT3 MMP14 SOAT1	1.67e-04	196	60	5	7408_UP
Drug	(-)-quinpirole hydrochloride; Up 200; 1uM; MCF7; HG-U133A	SIDT2 CHI3L2 CDC42BPB DDC SOAT1	1.71e-04	197	60	5	456_UP
Drug	alpha-Santonin [481-06-1]; Down 200; 16.2uM; MCF7; HT_HG-U133A	PIGN NDST1 SIDT2 POFUT1 SOAT2	1.71e-04	197	60	5	3877_DN
Drug	Diltiazem hydrochloride [33286-22-5]; Up 200; 8.8uM; MCF7; HT_HG-U133A	KCNJ4 INPP5B NBEAL2 DEPDC5 POFUT1	1.71e-04	197	60	5	1532_UP
Drug	Lidocaone hydrochloride [73-78-9]; Up 200; 14.8uM; MCF7; HT_HG-U133A	PIGN ETNK2 DEPDC5 POFUT1 B3GNT3	1.75e-04	198	60	5	1499_UP
Drug	Diflorasone Diacetate [33564-31-7]; Up 200; 8uM; MCF7; HT_HG-U133A	HTR1B CALB1 DEPDC5 POFUT1 TTPA	1.75e-04	198	60	5	4158_UP
Drug	Diprophylline [479-18-5]; Down 200; 15.8uM; MCF7; HT_HG-U133A	NDST1 SIDT2 TMEM62 SIDT1 CDC42BPB	1.75e-04	198	60	5	1689_DN
Drug	Quinidine hydrochloride monohydrate [6151-40-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A	SUGP2 CLSTN2 B3GNT3 TRAM2 RASAL2	1.75e-04	198	60	5	6267_UP
Drug	Chlorthalidone [77-36-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A	NDST1 INPP5B MMP14 SOAT2 RASAL2	1.79e-04	199	60	5	3198_UP
Drug	clozapine; Up 200; 10uM; MCF7; HT_HG-U133A_EA	SIDT2 ETNK2 POFUT1 B3GNT3 SOAT2	1.79e-04	199	60	5	1009_UP
Drug	Streptozotocin [18883-66-4]; Down 200; 15uM; PC3; HT_HG-U133A	SIDT2 TMEM62 INPP5B MMP14 SOAT1	1.79e-04	199	60	5	5836_DN
Drug	Simvastatin [79902-63-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	NDST1 SIDT2 B3GNT3 TRAM2 MMP14	1.84e-04	200	60	5	3340_DN
Drug	isobutyramide	TYR HBZ HEPH	1.86e-04	42	60	3	CID000068424
Drug	CP-113,818	SOAT2 SOAT1	1.89e-04	8	60	2	CID000164373
Drug	4-methylumbelliferyl elaidate	SOAT2 SOAT1	1.89e-04	8	60	2	CID000087585
Drug	vanillyl alcohol	TYR CALB1	1.89e-04	8	60	2	CID000062348
Drug	arjunolic acid	SOAT2 SOAT1	1.89e-04	8	60	2	CID000073641
Drug	Methyldopa	TYR DDC	1.89e-04	8	60	2	ctd:D008750
Drug	mecoprop	HTR1B SERINC3 CLSTN2	2.13e-04	44	60	3	CID000007153
Drug	benzyl benzoate	STAG2 XPR1	2.43e-04	9	60	2	CID000002345
Drug	cetyl ether	SOAT2 SOAT1	2.43e-04	9	60	2	CID000077757
Drug	phenacemide	KCNK6 SOAT1	2.43e-04	9	60	2	CID000004753
Drug	propanoyl	SOAT2 SOAT1	2.43e-04	9	60	2	CID000139982
Drug	AC1L2O7B	TYR DDC	2.43e-04	9	60	2	CID000125213
Drug	PD138142-15	SOAT2 SOAT1	2.43e-04	9	60	2	CID003025787
Drug	bromopropylate	SERINC3 CLSTN2	3.03e-04	10	60	2	CID000028936
Drug	N-methylisatoic anhydride	SOAT2 SOAT1	3.03e-04	10	60	2	CID000025160
Drug	6-hydroxydopa	TYR DDC	3.03e-04	10	60	2	CID000033755
Drug	AC1L9BFY	KCNJ4 SOAT1	3.03e-04	10	60	2	CID000441673
Drug	stearoylcarnitine	SOAT2 SOAT1	3.03e-04	10	60	2	CID000005282
Disease	X-21319 measurement	ACSM2A ACSM2B	4.07e-06	2	60	2	EFO_0800807
Disease	X-11478 measurement	ACSM2A ACSM2B	1.22e-05	3	60	2	EFO_0021242
Disease	3-hydroxyhexanoate measurement	ACSM2A ACSM2B	4.05e-05	5	60	2	EFO_0800378
Disease	indoleacetoylcarnitine measurement	ACSM2A ACSM2B	6.07e-05	6	60	2	EFO_0800106
Disease	cholesteryl ester 24:4 measurement	SOAT2 SOAT1	8.48e-05	7	60	2	EFO_0021447
Disease	cholesteryl ester 24:5 measurement	SOAT2 SOAT1	2.65e-04	12	60	2	EFO_0021448
Disease	nevus count, cutaneous melanoma	TYR TTC7B RAPGEF1	8.55e-04	91	60	3	EFO_0000389, EFO_0004632
Disease	nephrotic syndrome (biomarker_via_orthology)	DDC SOAT2	1.09e-03	24	60	2	DOID:1184 (biomarker_via_orthology)
Disease	azoospermia (implicated_via_orthology)	NDST1 CDC42BPB	1.38e-03	27	60	2	DOID:14227 (implicated_via_orthology)
Disease	anti-basement membrane glomerulonephritis (biomarker_via_orthology)	RAPGEF1 MMP14	1.71e-03	30	60	2	DOID:4780 (biomarker_via_orthology)
Disease	microcephaly (implicated_via_orthology)	ETNK2 STIL	1.94e-03	32	60	2	DOID:10907 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DHDLFSFADLIFGKW	TMEM62	296	Q0P6H9
KDACWFHLAIFDFFT	HTR1B	341	P28222
FSVNWFILFNDALVH	ALS2	931	Q96Q42
PAKFNFASDVLDHWA	ACSM2A	41	Q08AH3
AALLHFFFLAAFTWM	ADGRL3	931	Q9HAR2
FINLLSFDFHGSWEK	CHI3L2	206	Q15782
GFFEHLEKWFDQCSL	CCDC180	881	Q9P1Z9
FDQADTFRPAEFHWK	CLSTN2	431	Q9H4D0
VEFADSFNFNPHKWL	DDC	291	P20711
LLFSATFEDSVWHFA	DDX25	276	Q9UHL0
FFKGDKHWVFDEASL	MMP14	381	P50281
APDFLAFKEHFSLAW	IQCH	281	Q86VS3
FASDISELWALFAHF	LARGE2	206	Q8N3Y3
LFWCIAFFHGDLEAS	KCNJ4	76	P48050
IFAHLEEAWSFLDAF	KCNK6	191	Q9Y257
GNFSLNAAFEIKLHW	DEPDC5	1376	O75140
VQVNKFALASHFFWA	ETNK2	331	Q9NVF9
SFIFEANEAWKDFHG	KLHL8	41	Q9P2G9
SAFKADEFLNWHALF	KRTDAP	56	P60985
ENGFFKDRHWLFTEF	METTL2B	86	Q6P1Q9
KADNIFWGEHFEFFS	RASAL2	206	Q9UJF2
NFWLHKLVFVDAVAF	NDST1	286	P52848
FKKHAFFEGLNWENI	CDC42BPB	336	Q9Y5S2
ENGFFKDRHWLFTEF	METTL2A	86	Q96IZ6
ADFTAEAHAAWDKFL	HBZ	116	P02008
GAWLEKNFAAFFSHI	HEATR5A	316	Q86XA9
HFSDKQWLCDFGFLV	EPM2AIP1	371	Q7L775
ITASQFFEIWLHFDA	CALB1	11	P05937
GDILQWDFHDSFFNL	B3GNT3	171	Q9Y2A9
WDFHDSFFNLTLKQV	B3GNT3	176	Q9Y2A9
FFFHDTPKEEEWFKA	INPP5B	391	P32019
FWDQFHVSFNKSELF	POFUT1	151	Q9H488
FFAFLHCWLNAFAEM	SOAT1	381	P35610
DFFDDHDIWHFLSSI	SIDT2	791	Q8NBJ9
VEHDHETFWLFQFFL	TBC1D21	176	Q8IYX1
QHLLFNFHLWTLSDF	NBEAL2	1021	Q6ZNJ1
FFLLFSVVDENLSWH	HEPH	226	Q9BQS7
YHFDNSWKAFLGELT	SHPRH	106	Q149N8
VHNGFWFFKFAAAIA	SERINC1	121	Q9NRX5
FAFLHCWLNAFAEML	SOAT2	356	O75908
WRAFDFKEFSHLEDF	AKR1B15	296	C9JRZ8
FFNLTLKEIHFLAWA	B3GNT9	201	Q6UX72
PAKFNFASDVLDHWA	ACSM2B	41	Q68CK6
LWAAAFLTLHSAQAF	CLEC19A	6	Q6UXS0
AFHTKSSKWVFFDDA	USP53	306	Q70EK8
FHKVGFADFWLADQL	XPR1	386	Q9UBH6
FDLHWAAVTLANNFK	STIL	186	Q15468
ARVHWAFKFFDSQGA	TICRR	41	Q7Z2Z1
FFNDFSDHLAEEALW	RAPGEF1	1041	Q13905
AFHNAHDLSKWDLFA	STAG2	696	Q8N3U4
DFFDDHDIWHFLSAT	SIDT1	786	Q9NXL6
FADENNEKLFSAWAA	TRAM2	236	Q15035
LWFLHDQNSSAFKFY	SUGP2	816	Q8IX01
FLLHHAFVDSIFEQW	TYR	386	P14679
LDHLFDCFKASWTNA	USP9Y	466	O00507
AIFDLEGWQFSHAFQ	TTPA	156	P49638
TWVFDNVKDFFHHAR	PIGN	176	O95427
RAAVHNGFWFFKIAA	SERINC3	126	Q13530
KFAFEEFHLWYQFAL	TTC7B	391	Q86TV6
AFDFNVSLQDHFKWV	NECAP1	116	Q8NC96
FDFNVALQDHFKWVK	NECAP2	116	Q9NVZ3