Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K4me/H3K4me2/H3K4me3 demethylase activity

KDM5C KDM5D

4.13e-066112GO:0034647
GeneOntologyMolecularFunctionhistone H3K4 demethylase activity

KDM5C KDM5D

7.71e-068112GO:0032453
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM5C KDM5D

1.03e-0428112GO:0141052
GeneOntologyMolecularFunctionhistone demethylase activity

KDM5C KDM5D

1.27e-0431112GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

KDM5C KDM5D

1.36e-0432112GO:0140457
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

KDM5C KDM5D NOS3

1.41e-04194113GO:0016705
GeneOntologyMolecularFunctiondemethylase activity

KDM5C KDM5D

2.58e-0444112GO:0032451
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

KDM5C KDM5D

5.63e-0465112GO:0016706
GeneOntologyMolecularFunctiondioxygenase activity

KDM5C KDM5D

1.27e-0398112GO:0051213
GeneOntologyMolecularFunctionbeta-catenin binding

FOXO1 NOS3

1.90e-03120112GO:0008013
GeneOntologyMolecularFunctionhistone modifying activity

KDM5C KDM5D

6.73e-03229112GO:0140993
GeneOntologyMolecularFunctiontranscription factor binding

KDM5C FOXO1 KDM5D

7.02e-03753113GO:0008134
GeneOntologyMolecularFunctionoxidoreductase activity

KDM5C KDM5D NOS3

7.37e-03766113GO:0016491
GeneOntologyBiologicalProcessnegative regulation of muscle adaptation

FOXO1 NOS3

2.70e-0515112GO:0014745
DomainLys_sp_deMease-like_dom

KDM5C KDM5D

1.89e-064112IPR013637
DomainPLU-1

KDM5C KDM5D

1.89e-064112PF08429
Domainzf-C5HC2

KDM5C KDM5D

3.15e-065112PF02928
DomainZnf_C5HC2

KDM5C KDM5D

3.15e-065112IPR004198
DomainJmjN

KDM5C KDM5D

1.42e-0510112PF02375
DomainJMJN

KDM5C KDM5D

1.42e-0510112PS51183
DomainJmjN

KDM5C KDM5D

1.42e-0510112IPR003349
DomainJmjN

KDM5C KDM5D

1.42e-0510112SM00545
DomainBRIGHT

KDM5C KDM5D

3.30e-0515112SM00501
Domain-

KDM5C KDM5D

3.30e-05151121.10.150.60
DomainARID

KDM5C KDM5D

3.30e-0515112PF01388
DomainARID_dom

KDM5C KDM5D

3.30e-0515112IPR001606
DomainARID

KDM5C KDM5D

3.30e-0515112PS51011
DomainJmjC

KDM5C KDM5D

8.64e-0524112PF02373
DomainJMJC

KDM5C KDM5D

1.55e-0432112PS51184
DomainJmjC_dom

KDM5C KDM5D

1.55e-0432112IPR003347
DomainJmjC

KDM5C KDM5D

1.65e-0433112SM00558
DomainZinc_finger_PHD-type_CS

KDM5C KDM5D

6.43e-0465112IPR019786
DomainPHD

KDM5C KDM5D

8.55e-0475112PF00628
DomainZnf_PHD-finger

KDM5C KDM5D

9.48e-0479112IPR019787
DomainPHD

KDM5C KDM5D

1.20e-0389112SM00249
DomainZnf_PHD

KDM5C KDM5D

1.25e-0391112IPR001965
DomainZF_PHD_2

KDM5C KDM5D

1.37e-0395112PS50016
DomainZF_PHD_1

KDM5C KDM5D

1.40e-0396112PS01359
DomainZnf_FYVE_PHD

KDM5C KDM5D

3.23e-03147112IPR011011
Domain-

KDM5C KDM5D

2.75e-024491123.30.40.10
DomainZnf_RING/FYVE/PHD

KDM5C KDM5D

2.86e-02459112IPR013083
PathwayREACTOME_HDMS_DEMETHYLATE_HISTONES

KDM5C KDM5D

1.82e-0429102MM14934
PathwayWP_PI3KAKTMTOR_SIGNALING_AND_THERAPEUTIC_OPPORTUNITIES_IN_PROSTATE_CANCER

FOXO1 NOS3

2.22e-0432102M39445
PathwayPID_ANGIOPOIETIN_RECEPTOR_PATHWAY

FOXO1 NOS3

5.23e-0449102M92
PathwayREACTOME_HDMS_DEMETHYLATE_HISTONES

KDM5C KDM5D

5.45e-0450102M27232
PathwayWP_AGERAGE_PATHWAY

FOXO1 NOS3

9.48e-0466102M39420
PathwayWP_LEPTIN_SIGNALING

FOXO1 NOS3

1.26e-0376102M39491
PathwayWP_EGFEGFR_SIGNALING

FOXO1 NOS3

5.56e-03162102M39334
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KDM5C KDM5D

6.46e-03175102MM14941
PathwayWP_OREXIN_RECEPTOR_PATHWAY

FOXO1 NOS3

8.36e-03200102M48048
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC4A9 MBTPS1 MCUB

1.29e-02736103M27287
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KDM5C KDM5D

1.51e-02272102M29619
PathwayWP_IL18_SIGNALING

MBTPS1 HSPB8

1.52e-02273102M39818
PathwayWP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING

FOXO1 NOS3

1.84e-02302102M39719
Pubmed

Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.

KDM5C KDM5D

9.09e-08211232081420
Pubmed

Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.

KDM5C KDM5D

9.09e-0821129060413
Pubmed

Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.

KDM5C KDM5D

9.09e-08211210441747
Pubmed

Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.

KDM5C KDM5D

9.09e-08211216416087
Pubmed

A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.

KDM5C KDM5D

9.09e-0821127524912
Pubmed

Identification of a mouse male-specific transplantation antigen, H-Y.

KDM5C KDM5D

2.73e-0731127544442
Pubmed

Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.

KDM5C KDM5D

5.45e-07411216541399
Pubmed

X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.

KDM5C KDM5D

5.45e-07411232732223
Pubmed

A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.

KDM5C KDM5D

5.45e-0741127951230
Pubmed

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

KDM5C KDM5D

5.45e-07411217320160
Pubmed

eNOS Regulates Lymphatic Valve Specification by Controlling β-Catenin Signaling During Embryogenesis in Mice.

FOXO1 NOS3

9.09e-07511237767708
Pubmed

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.

KDM5C KDM5D

7.08e-061311224619213
Pubmed

Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.

KDM5C KDM5D

7.08e-061311214660691
Pubmed

FOXO1-mediated activation of Akt plays a critical role in vascular homeostasis.

FOXO1 NOS3

8.26e-061411224874427
Pubmed

Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.

KDM5C KDM5D

9.53e-061511214762062
Pubmed

Sex differences in sex chromosome gene expression in mouse brain.

KDM5C KDM5D

1.39e-051811212023983
Pubmed

FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac.

FOXO1 NOS3

3.42e-052811235297995
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KDM5C KDM5D

4.78e-053311226864203
Pubmed

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

MBTPS1 FOXO1 NOS3

5.80e-0525011318660489
Pubmed

Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome.

FOXO1 NOS3

7.78e-054211229438518
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

KDM5C KRBA1 FOXO1 KDM5D

8.38e-0580811420412781
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

KDM5C KDM5D

1.06e-044911234368113
Pubmed

Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.

FOXO1 NOS3

1.15e-045111220682687
Pubmed

New nomenclature for chromatin-modifying enzymes.

KDM5C KDM5D

1.44e-045711218022353
Pubmed

Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.

FOXO1 KDM5D

1.59e-046011218023262
Cytoband7q36

KRBA1 NOS3

1.83e-05271127q36
CytobandEnsembl 112 genes in cytogenetic band chr7q36

KRBA1 NOS3

6.42e-04159112chr7q36
GeneFamilyAT-rich interaction domain containing

KDM5C KDM5D

1.35e-051572418
GeneFamilyPHD finger proteins|Lysine demethylases

KDM5C KDM5D

3.53e-052472485
GeneFamilyPHD finger proteins

KDM5C KDM5D

5.06e-04907288
ToppCell(2)_Fibroblasts-(23)_Fibro-4|World / Cell class and subclass of bone marrow stroma cells in homeostatis

HSPB8 FOXO1 MCUB

1.33e-05197113a183919023a4aca90a06be0e5e89c817b38c5574
ToppCellLPS_only-Endothelial-Endothelial-Vein|LPS_only / Treatment groups by lineage, cell group, cell type

HSPB8 FOXO1 NOS3

1.39e-05200113b036f5e22c95a3b14391785b6e91aa183b9bc9a8
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Vip_Itih5|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HSPB8 MCUB

3.57e-04116112605bd4fdf547cc41783e99cd78425760ef6461ef
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Akr1c18_Ntf3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC4A9 HSPB8

5.88e-041491121e77f03d2b32f366018fec3462d1b75f6e7febb9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A9 FOXO1

5.95e-0415011287968ce885a4959616f0321f58517fe8029ba1b1
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KDM5C KRBA1

6.19e-0415311292a5307b8e4dcf9ee42134b4c0645f9d488df61a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FOXO1 NOS3

6.35e-0415511259035d792c26d870a8b097939e97fa47859ba68c
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A9 FOXO1

6.52e-04157112c17c5c01fcb65c453690c265ec4f300ecdfefd34
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC4A9 NOS3

6.60e-0415811278b48b110b777bcc4c07cd23388bee911c0231d6
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCUB NOS3

6.60e-04158112e52eff2bd1e7e0ce9c278ed5109802865e0fe69c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCUB NOS3

6.60e-04158112a2efcc184ef13d81373e3690253ba35f6be09c5f
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCUB NOS3

6.60e-04158112ba9998cbf786c515d30fe42de02c7a246db1b6f9
ToppCelldroplet-Marrow-BM-30m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCUB PSD

6.94e-0416211275df7ff779a3b9159ba97d852da1f8df650b9ce5
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRSN2 PSD

7.19e-0416511202cd87dfa2ca40e13455a4b9308477e82f76289b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A9 FOXO1

7.19e-04165112dc570154baed59ed109e5369589448e075ba66a9
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRSN2 PSD

7.19e-041651126d8b5669eee9b0903c9260fea707d186c9d7fefa
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

7.28e-041661127a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HSPB8 NRSN2

7.28e-04166112006ced12f69ef13ddcba5a3891ddc7c18c384863
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HSPB8 NRSN2

7.28e-041661126bb3410e65c971acc458c472015afcec6de6e310
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

7.28e-04166112bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HSPB8 NRSN2

7.28e-04166112ac28c8cac1e94be0c47fb862c5809c92cdaa11f3
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

HSPB8 NRSN2

7.28e-04166112823ec03714884cb860a1260410feac8c536b6d06
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FOXO1 NOS3

7.28e-04166112f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCellfacs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A9 NOS3

7.46e-0416811206dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

KRBA1 PSD

7.46e-04168112ca94b29c1030484143a77f2df06dad74d2c6136e
ToppCellfacs-Heart-RA-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A9 NOS3

7.46e-041681121002f058a340763e3d8de0bd1f0547a903526ec6
ToppCellCOVID-19_Mild-PLT_2|World / Disease Group and Platelet Clusters

MCUB KDM5D

7.54e-041691126abfdc8b437f19c03b408bedc245059d28c6ba6a
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

7.54e-0416911258136b8a0bf2dab45c91a053ef7225ea49ccb871
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPB8 FOXO1

7.54e-041691122456b3e7776e8a2214972be1b4d66a3ca5480ae0
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

7.54e-0416911204c6ed38e1d1befba5ef5f37a3c1e045a0b163d6
ToppCellMild_COVID-19-Myeloid-MoAM5|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

HSPB8 NRSN2

7.63e-04170112b2daf46ab5a49590ede8f75e4240bfe6e9d8b764
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FOXO1 NOS3

7.72e-041711123112d15f2a28cf4a71992db4971d960716dc1264
ToppCellfacs-Heart-LV-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDM5D NOS3

7.81e-041721126ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCellfacs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDM5D NOS3

7.81e-04172112f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FOXO1 NOS3

7.90e-04173112b0ff9808e38cb64a734ced498cd0546728746cd5
ToppCellCOVID-19_Mild-PLT_2|COVID-19_Mild / Disease Group and Platelet Clusters

MCUB KDM5D

7.90e-04173112d11705e56b6b21eec963ea224717f27680c781ed
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FOXO1 NRSN2

7.99e-041741124a18b51501eaaeb7907e99316ba8ae15b2c7d529
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A9 FOXO1

7.99e-041741125f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

8.09e-041751122e54961846c65b185d9bd6e305dd81205579d890
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

8.09e-04175112efa6a05f7417d46141b6e635f258c126b7a03aa1
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A9 FOXO1

8.09e-0417511277c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A9 FOXO1

8.18e-041761126c7edf1cb38644500bce6c5a1dd90bbe17415cdb
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A9 FOXO1

8.18e-04176112c2c4306476989bc2fb30dab00250ef7915842f13
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

8.18e-0417611296779273b94345250cf53ba671203345b43d9e00
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

8.18e-0417611277516048aefbe1f48e825052756df0c310c1c486
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A9 FOXO1

8.18e-0417611225ebc8716aa44e44fce577701e3e82c6745a75ab
ToppCell3'-Adult-LargeIntestine-Hematopoietic-T_cells-SELL+_CD4_T|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KRBA1 MCUB

8.27e-04177112bb496fbec7cacc52847abe2b2714249c47879763
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FOXO1 NOS3

8.36e-041781120139b42494c1186390b12106dea7957e2b6717c2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A9 FOXO1

8.36e-0417811251d2188406f04329311b2efd1108fc36617a860e
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRSN2 PSD

8.46e-04179112a3922476f33d2e4137a12dbda21a1703dff79684
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A9 FOXO1

8.55e-04180112cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCUB NOS3

8.55e-041801129c47852c0a723e2f5cd6898afff4c31a0da06905
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCUB NOS3

8.55e-04180112499d5fe71e0dc20cffdf85e3b3f14eb4e83e3a3d
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCUB NOS3

8.55e-041801122405aa5699a8d8cf4c6b3dca07510e774728ac50
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

8.64e-041811124d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A9 FOXO1

8.64e-0418111230729f0364f719c044712a51453e22dc2c1a232b
ToppCelldroplet-Marrow-BM-1m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXO1 MCUB

8.64e-0418111289c551de26de047c316c91ac1d97bdf728a33d9e
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDM5D NOS3

8.64e-041811124ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPB8 PSD

8.74e-0418211237547b36264090b49a193a8ef3a8d88e647f0b79
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FOXO1 NOS3

8.74e-04182112345d0f9d5ee30434bc2aac17608ccdc9e61c8fa3
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

8.83e-041831123427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

8.83e-04183112fc9a7ba148c22d0c8a46f6bc56c772929ac496f7
ToppCellCOVID-CD4-naive_CD4|COVID / Condition, Cell_class and T cell subcluster

MCUB PSD

8.93e-0418411200db55970d336a301035efe43a4ab4db62627f38
ToppCellEndothelial-E|World / shred on cell class and cell subclass (v4)

FOXO1 NOS3

8.93e-04184112b4c561924c508536fd2112e91e32176b95fdf63a
ToppCellP28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FOXO1 NOS3

8.93e-041841128ed22b1af04a711203293e7a8b3df6fb9222fad5
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KRBA1 MCUB

9.03e-0418511287151ab95530e70d61328b336518df58db584acb
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXO1 NOS3

9.12e-041861122d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCellCOVID-19-kidney-CD-IC-B|kidney / Disease (COVID-19 only), tissue and cell type

SLC4A9 FOXO1

9.22e-04187112ce05b89860573fe0356102e2998d1ef6d1968034
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-bladder_mesenchymal_cell_(Scara5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPB8 MCUB

9.22e-041871127beba2a5d5978f2ae7d8bde10815705cf2572211
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FOXO1 NOS3

9.22e-04187112d6765854154557794815514c0aa355bc74b8523e
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPB8 PSD

9.22e-041871123912bbb610a4a84791e9bda92a2d57a52c31d29e
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FOXO1 NOS3

9.22e-0418711266ebe1788d51b3e17bec6cdb219f709756b4e530
ToppCellEndothelial-Endothelial-E|Endothelial / shred on cell class and cell subclass (v4)

FOXO1 NOS3

9.32e-041881122777eb7689b271c199021fe7d9db88ccebff14de
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FOXO1 NOS3

9.32e-041881125eb107122064f0a99dfd445cc87d3766f7257216
ToppCellP28-Endothelial-large_vessel_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FOXO1 NOS3

9.32e-04188112263169029293e005bcffd87db20221fdd2d3917e
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FOXO1 NOS3

9.32e-041881125bc1537e079c7435196c163bff5f639ea392a33a
ToppCell3'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPB8 PSD

9.42e-0418911263449d9f1e78ff2bc8786eb88a0d177fe30c7f4d
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FOXO1 NOS3

9.42e-04189112360f09f46231a83f99d8fa0158b72a38068e1642
ToppCell3'-Adult-LargeIntestine-Mesenchymal-myocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPB8 PSD

9.42e-04189112f7e2ee5047792ab9ef6472fa88e2d193cdea6fa0
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

9.42e-04189112d17e8467699c7ca7694a313c26111f085df5204e
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

9.42e-041891129da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

9.42e-04189112feedac2751ed770f80bc56fec31662b5b3826f58
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FOXO1 KDM5D

9.42e-04189112d05e043d0874b8563b9f5514f6c884b35c603e3a
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

9.52e-041901129b0ad888eb20acc011904d8593bc32bdef18d050
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPB8 PSD

9.52e-04190112990ac07f4b0a22041daac7502f74fafd6d258cba
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

9.52e-04190112d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCellGlobus_pallidus-Neuronal|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

NRSN2 PSD

9.52e-04190112416de85d8841dac883faa6f5339b2fb461a09e82
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPB8 PSD

9.52e-0419011239ecdf8815e235771132684dfc1aff1917e20965
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FOXO1 NOS3

9.52e-04190112e1b721bb74561fe51c53328a0394c9954e489049
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPB8 PSD

9.52e-04190112fc9bbe5e6e0ec3cfa47bf479d8b09a0fc53169cc
ToppCell(2)_Fibroblasts-(21)_Fibro-2|World / Cell class and subclass of bone marrow stroma cells in homeostatis

HSPB8 MCUB

9.62e-041911125ee353c79055c08e8a3e2b43a0345bceb09f3890
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

9.62e-04191112b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPB8 PSD

9.62e-04191112de2cd94ee88a7754f86d39469e38374d668210c7
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

9.62e-0419111227f23c2254b610abac1a88d0fecff305addde9da
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

9.62e-041911123307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCelldroplet-Lung-LUNG-1m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXO1 NOS3

9.62e-04191112c379a499dabf3c9ed80f47adbb2d949821c5b053
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

9.62e-0419111254bbccc554f43ba2ebdf9ea191b94c8f16081b53
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXO1 NOS3

9.62e-041911120e8a73f01e3ec95d242c09231bcf3790324d0a67
ToppCelldroplet-Lung-LUNG-1m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXO1 NOS3

9.62e-041911129fc674a58f20b47255e4457d5195c8cff17b0414
ToppCellP07-Endothelial-large_vessel_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FOXO1 NOS3

9.62e-04191112d162917816dd2e4767c97447c1cddae9397713ab
Drugnitroindole

HSPB8 NOS3

1.27e-064112CID000043297
Drugaminosteroid

MBTPS1 KDM5D

1.92e-0514112CID000040111
Drugcarbonyl sulfide

SLC4A9 KDM5C KDM5D

2.06e-05116113CID000010039
Drugspermine nitric oxide complex

FOXO1 NOS3

2.54e-0516112ctd:C091861
DrugDAF-2DA

KDM5D NOS3

5.34e-0523112CID006603693
DrugAZFd

KDM5C KDM5D

5.34e-0523112CID000196489
Drug2-phenylimidazole

MBTPS1 NOS3

5.82e-0524112CID000069591
DrugAC1NDZBN

MBTPS1 NOS3

7.40e-0527112CID004634037
Drugradicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT_HG-U133A

KDM5C FOXO1 NRSN2

9.70e-051951135579_DN
Drug2-propylpentanoic acid; Down 200; 200uM; MCF7; HT_HG-U133A

MBTPS1 KDM5C FOXO1

9.70e-051951131639_DN
DrugLY294002; Down 200; 10uM; PC3; HT_HG-U133A

MBTPS1 HSPB8 FOXO1

9.85e-051961135942_DN
DrugUrsolic acid [77-52-1]; Down 200; 8.8uM; PC3; HT_HG-U133A

MBTPS1 HSPB8 FOXO1

1.00e-041971132067_DN
DrugConvolamine hydrochloride [500-56-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A

KDM5C FOXO1 NRSN2

1.02e-041981132771_DN
Drugglabridin

MBTPS1 NOS3

1.90e-0443112CID000124052
DrugAC1MPVH8

MBTPS1 NOS3

1.90e-0443112CID003441849
DrugAC1L9LC0

SLC4A9 KDM5D

2.08e-0445112CID000447871
DrugBiM4

MBTPS1 PSD NOS3

2.91e-04283113CID000002399
Drugendotoxin, Escherichia coli

HSPB8 NOS3

3.22e-0456112ctd:C044101
Drugazafagomine

KDM5C KDM5D

3.34e-0457112CID011957435
Drug9,10-phenanthrenequinone

HSPB8 NOS3

3.82e-0461112CID000006763
DrugD2926_SIGMA

MBTPS1 NOS3

4.21e-0464112CID006400050
Drugnitrate

SLC4A9 KDM5D NOS3

4.61e-04331113CID000000943
DrugAM251

FOXO1 NOS3

5.03e-0470112CID000002125
Drugcysteic acid

SLC4A9 KDM5C

5.03e-0470112CID000025701
Drugcandesartan

FOXO1 NOS3

5.62e-0474112ctd:C081643
DrugAC1L1DXN

MBTPS1 NOS3

7.59e-0486112CID000002552
Drug2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

HSPB8 FOXO1 NOS3

8.00e-04400113ctd:C085911
DrugAC1L1BEQ

MBTPS1 NOS3

8.86e-0493112CID000001407
DrugLinoleic Acid

FOXO1 NOS3

1.00e-0399112ctd:D019787
Diseasesyndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)

KDM5C KDM5D

6.20e-074102DOID:0060809 (implicated_via_orthology)
Diseasesyndromic intellectual disability (implicated_via_orthology)

KDM5C KDM5D

1.24e-0516102DOID:0050888 (implicated_via_orthology)
Diseasealcohol use disorder (implicated_via_orthology)

KDM5C KDM5D PSD

3.30e-05195103DOID:1574 (implicated_via_orthology)
DiseasePulmonary Hypertension

FOXO1 NOS3

8.01e-0540102C0020542
Diseaseintellectual disability (implicated_via_orthology)

KDM5C KDM5D

2.83e-0475102DOID:1059 (implicated_via_orthology)
DiseaseProstatic Neoplasms

MBTPS1 FOXO1 NOS3

9.74e-04616103C0033578
DiseaseMalignant neoplasm of prostate

MBTPS1 FOXO1 NOS3

9.74e-04616103C0376358
Diseaseautism spectrum disorder (implicated_via_orthology)

KDM5C KDM5D

1.15e-03152102DOID:0060041 (implicated_via_orthology)
DiseaseEczema, allergic rhinitis

FOXO1 NOS3

2.29e-03215102EFO_0005854, HP_0000964

Protein segments in the cluster

PeptideGeneStartEntry
RWDPTARIPPPKCLP

SLC4A9

326

Q96Q91
PRPEPDLWKPLPQER

KRBA1

656

A5PL33
WPLPPPPQVLRVKLC

MCUB

26

Q9NWR8
PRPLPACPRLSWAKP

MBTPS1

921

Q14703
RTPPPFPGEPWKVCV

HSPB8

86

Q9UJY1
PPLPEIPRGIWRCPK

KDM5D

346

Q9BY66
EGPPVLCPRRPWPSL

NRSN2

46

Q9GZP1
PPGWVRDPRLPPCTL

NOS3

841

P29474
PLPRPRSCTWPLPRP

FOXO1

16

Q12778
ISPPRCPRRWLPEGP

PSD

16

A5PKW4
PPLPEIPKGVWRCPK

KDM5C

356

P41229