Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Wnt-protein binding	LRP6 LRP5 SFRP5	3.95e-05	34	39	3	GO:0017147
GeneOntologyMolecularFunction	histone H4K16 acetyltransferase activity	KAT7 KAT8	1.33e-04	9	39	2	GO:0046972
GeneOntologyMolecularFunction	histone H4K8 acetyltransferase activity	KAT7 KAT8	2.02e-04	11	39	2	GO:0043996
GeneOntologyMolecularFunction	histone H4K5 acetyltransferase activity	KAT7 KAT8	2.02e-04	11	39	2	GO:0043995
GeneOntologyMolecularFunction	toxin transmembrane transporter activity	LRP6 LRP5	2.42e-04	12	39	2	GO:0019534
GeneOntologyMolecularFunction	coreceptor activity	LRP6 LRP5 ERBB2	3.74e-04	72	39	3	GO:0015026
GeneOntologyMolecularFunction	Wnt receptor activity	LRP6 LRP5	4.96e-04	17	39	2	GO:0042813
GeneOntologyMolecularFunction	histone H4 acetyltransferase activity	KAT7 KAT8	9.16e-04	23	39	2	GO:0010485
GeneOntologyMolecularFunction	sulfur compound binding	CRISPLD2 BMP7 VTN ACACA	3.54e-03	323	39	4	GO:1901681
GeneOntologyMolecularFunction	histone acetyltransferase activity	KAT7 KAT8	4.46e-03	51	39	2	GO:0004402
GeneOntologyBiologicalProcess	negative regulation of Wnt signaling pathway, planar cell polarity pathway	LRP6 SFRP5	2.19e-05	4	40	2	GO:0141113
GeneOntologyBiologicalProcess	Norrin signaling pathway	LRP6 LRP5	3.65e-05	5	40	2	GO:0110135
GeneOntologyBiologicalProcess	establishment of blood-retinal barrier	LRP6 LRP5	5.47e-05	6	40	2	GO:1990963
GeneOntologyBiologicalProcess	primary neural tube formation	LRP6 BMP7 SFRP5 SEMA4C	8.47e-05	120	40	4	GO:0014020
GeneOntologyBiologicalProcess	neural tube formation	LRP6 BMP7 SFRP5 SEMA4C	1.30e-04	134	40	4	GO:0001841
GeneOntologyBiologicalProcess	pericardium morphogenesis	LRP6 BMP7	1.31e-04	9	40	2	GO:0003344
GeneOntologyBiologicalProcess	negative regulation of non-canonical Wnt signaling pathway	LRP6 SFRP5	1.31e-04	9	40	2	GO:2000051
GeneOntologyBiologicalProcess	negative regulation of morphogenesis of an epithelium	LRP6 BMP7	1.31e-04	9	40	2	GO:1905331
GeneOntologyBiologicalProcess	mesodermal cell migration	LRP6 LRP5	1.31e-04	9	40	2	GO:0008078
GeneOntologyBiologicalProcess	mesenchymal cell proliferation	LRP6 LRP5 BMP7	2.04e-04	59	40	3	GO:0010463
GeneOntologyBiologicalProcess	embryonic epithelial tube formation	LRP6 BMP7 SFRP5 SEMA4C	2.50e-04	159	40	4	GO:0001838
GeneOntologyBiologicalProcess	epithelial tube formation	LRP6 BMP7 SFRP5 SEMA4C	3.45e-04	173	40	4	GO:0072175
GeneOntologyBiologicalProcess	regulation of establishment of planar polarity involved in neural tube closure	LRP6 SFRP5	3.79e-04	15	40	2	GO:0090178
GeneOntologyBiologicalProcess	positive regulation of osteoblast proliferation	LRP5 HPSE	3.79e-04	15	40	2	GO:0033690
GeneOntologyBiologicalProcess	establishment of planar polarity involved in neural tube closure	LRP6 SFRP5	4.33e-04	16	40	2	GO:0090177
GeneOntologyBiologicalProcess	glomerulus development	MPV17 AMPD2 BMP7	4.47e-04	77	40	3	GO:0032835
GeneOntologyBiologicalProcess	tube formation	LRP6 BMP7 SFRP5 SEMA4C	4.63e-04	187	40	4	GO:0035148
GeneOntologyBiologicalProcess	morphogenesis of embryonic epithelium	LRP6 BMP7 SFRP5 SEMA4C	4.92e-04	190	40	4	GO:0016331
GeneOntologyBiologicalProcess	establishment of planar polarity of embryonic epithelium	LRP6 SFRP5	5.50e-04	18	40	2	GO:0042249
GeneOntologyBiologicalProcess	regulation of establishment of planar polarity	LRP6 SFRP5	6.14e-04	19	40	2	GO:0090175
GeneOntologyBiologicalProcess	convergent extension	LRP6 SFRP5	6.14e-04	19	40	2	GO:0060026
GeneOntologyBiologicalProcess	regulation of Wnt signaling pathway, planar cell polarity pathway	LRP6 SFRP5	6.14e-04	19	40	2	GO:2000095
GeneOntologyBiologicalProcess	establishment of blood-brain barrier	LRP6 LRP5	6.14e-04	19	40	2	GO:0060856
GeneOntologyBiologicalProcess	neural tube development	LRP6 BMP7 SFRP5 SEMA4C	6.19e-04	202	40	4	GO:0021915
GeneOntologyBiologicalProcess	cell migration involved in gastrulation	LRP6 LRP5	6.82e-04	20	40	2	GO:0042074
GeneOntologyBiologicalProcess	gastrulation	LRP6 LRP5 BMP7 VTN	7.42e-04	212	40	4	GO:0007369
GeneOntologyBiologicalProcess	cell migration in hindbrain	LRP6 SEMA4C	9.04e-04	23	40	2	GO:0021535
GeneOntologyCellularComponent	Wnt-Frizzled-LRP5/6 complex	LRP6 LRP5	3.56e-05	5	40	2	GO:1990851
GeneOntologyCellularComponent	Wnt signalosome	LRP6 LRP5	4.21e-04	16	40	2	GO:1990909
Domain	LRP5/6	LRP6 LRP5	4.25e-06	2	39	2	IPR017049
Domain	MOZ_SAS	KAT7 KAT8	4.23e-05	5	39	2	PF01853
Domain	HAT_MYST-type	KAT7 KAT8	4.23e-05	5	39	2	IPR002717
Domain	MYST_HAT	KAT7 KAT8	4.23e-05	5	39	2	PS51726
Domain	Abhydro_lipase	LIPF LIPJ	6.34e-05	6	39	2	PF04083
Domain	AB_hydrolase_lipase	LIPF LIPJ	6.34e-05	6	39	2	IPR006693
Domain	Lipase_euk	LIPF LIPJ	6.34e-05	6	39	2	IPR025483
Domain	Ldl_recept_b	LRP6 LRP5	3.81e-04	14	39	2	PF00058
Domain	LDLRB	LRP6 LRP5	3.81e-04	14	39	2	PS51120
Domain	LY	LRP6 LRP5	4.39e-04	15	39	2	SM00135
Domain	LDLR_classB_rpt	LRP6 LRP5	4.39e-04	15	39	2	IPR000033
Domain	Furin_repeat	ERBB2 PCSK4	6.36e-04	18	39	2	IPR006212
Domain	FU	ERBB2 PCSK4	6.36e-04	18	39	2	SM00261
Domain	Hemopexin-like_dom	MMP25 VTN	1.05e-03	23	39	2	IPR000585
Domain	Hemopexin-like_repeat	MMP25 VTN	1.05e-03	23	39	2	IPR018487
Domain	Hemopexin	MMP25 VTN	1.05e-03	23	39	2	PF00045
Domain	HEMOPEXIN	MMP25 VTN	1.05e-03	23	39	2	PS00024
Domain	-	MMP25 VTN	1.05e-03	23	39	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP25 VTN	1.05e-03	23	39	2	PS51642
Domain	HX	MMP25 VTN	1.05e-03	23	39	2	SM00120
Domain	LIPASE_SER	LIPF LIPJ	1.34e-03	26	39	2	PS00120
Domain	Abhydrolase_1	LIPF LIPJ	1.90e-03	31	39	2	PF00561
Domain	AB_hydrolase_1	LIPF LIPJ	2.15e-03	33	39	2	IPR000073
Domain	-	LRP6 LRP5	3.00e-03	39	39	2	2.120.10.30
Domain	LDLR_class-A_CS	LRP6 LRP5	3.15e-03	40	39	2	IPR023415
Domain	-	KAT7 KAT8	3.15e-03	40	39	2	3.40.630.30
Domain	Acyl_CoA_acyltransferase	KAT7 KAT8	3.97e-03	45	39	2	IPR016181
Domain	Ldl_recept_a	LRP6 LRP5	3.97e-03	45	39	2	PF00057
Domain	-	LRP6 LRP5	4.15e-03	46	39	2	4.10.400.10
Domain	6-blade_b-propeller_TolB-like	LRP6 LRP5	4.15e-03	46	39	2	IPR011042
Domain	LDLRA_1	LRP6 LRP5	4.51e-03	48	39	2	PS01209
Domain	LDLRA_2	LRP6 LRP5	4.70e-03	49	39	2	PS50068
Domain	LDrepeatLR_classA_rpt	LRP6 LRP5	4.70e-03	49	39	2	IPR002172
Domain	LDLa	LRP6 LRP5	4.70e-03	49	39	2	SM00192
Domain	Glycoside_hydrolase_SF	SI HPSE	5.47e-03	53	39	2	IPR017853
Pathway	WP_WNTBETACATENIN_SIGNALING_INHIBITORS_IN_CURRENT_AND_PAST_CLINICAL_TRIALS	LRP6 LRP5	5.96e-05	5	35	2	M48304
Pathway	REACTOME_SIGNALING_BY_RNF43_MUTANTS	LRP6 LRP5	1.66e-04	8	35	2	M27433
Pathway	REACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_WNT_LIGAND_ANTAGONISTS	LRP6 LRP5	1.66e-04	8	35	2	MM14976
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4	LRP6 LRP5	5.35e-04	14	35	2	M47834
Pathway	WP_BREAST_CANCER_PATHWAY	LRP6 LRP5 ERBB2 ARAF	5.51e-04	154	35	4	M39739
Pathway	REACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_WNT_LIGAND_ANTAGONISTS	LRP6 LRP5	6.16e-04	15	35	2	M27273
Pathway	KEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY	ERBB2 ARAF	7.03e-04	16	35	2	M47381
Pathway	WP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS	LRP6 LRP5 VTN	7.44e-04	72	35	3	M39403
Pathway	WP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS	LRP6 LRP5 VTN	7.74e-04	73	35	3	MM15906
Pubmed	Evidence against a human cell-specific role for LRP6 in anthrax toxin entry.	LRP6 LRP5	1.29e-06	2	40	2	18350154
Pubmed	Clinical Phenotype and Relevance of LRP5 and LRP6 Variants in Patients With Early-Onset Osteoporosis (EOOP).	LRP6 LRP5	1.29e-06	2	40	2	33118644
Pubmed	Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.	LRP6 LRP5	1.29e-06	2	40	2	21887268
Pubmed	PAR1&2 driven placenta EVT invasion act via LRP5/6 as coreceptors.	LRP6 LRP5	1.29e-06	2	40	2	33136328
Pubmed	Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population.	LRP6 LRP5	1.29e-06	2	40	2	18493104
Pubmed	LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.	LRP6 LRP5	1.29e-06	2	40	2	15084453
Pubmed	Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.	LRP6 LRP5	1.29e-06	2	40	2	30668923
Pubmed	Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.	LRP6 LRP5	1.29e-06	2	40	2	22433869
Pubmed	Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration.	LRP6 LRP5	1.29e-06	2	40	2	33164872
Pubmed	Epidermal growth factor-induced heparanase nucleolar localization augments DNA topoisomerase I activity in brain metastatic breast cancer.	ERBB2 HPSE	1.29e-06	2	40	2	20164500
Pubmed	LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.	LRP6 LRP5	1.29e-06	2	40	2	25902418
Pubmed	Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.	LRP6 LRP5	1.29e-06	2	40	2	25802278
Pubmed	[Correlation between lymph-node metastasis and combined expression of Hpa and C-erbB-2 of invasive ductal breast carcinoma].	ERBB2 HPSE	1.29e-06	2	40	2	18390199
Pubmed	The involvement of the canonical Wnt-signaling receptor LRP5 and LRP6 gene variants with ADHD and sexual dimorphism: Association study and meta-analysis.	LRP6 LRP5	1.29e-06	2	40	2	30474181
Pubmed	In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions.	LRP6 LRP5	1.29e-06	2	40	2	36552732
Pubmed	Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes.	LRP6 LRP5	1.29e-06	2	40	2	25783012
Pubmed	Gene targeting approaches in mice: assessing the roles of LRP5 and LRP6 in osteoblasts.	LRP6 LRP5	1.29e-06	2	40	2	19147944
Pubmed	Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.	LRP6 LRP5	1.29e-06	2	40	2	15537447
Pubmed	Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina.	LRP6 LRP5	1.29e-06	2	40	2	33545636
Pubmed	LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin.	LRP6 LRP5	1.29e-06	2	40	2	17335347
Pubmed	Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density.	LRP6 LRP5	1.29e-06	2	40	2	12579474
Pubmed	The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development.	LRP6 LRP5	1.29e-06	2	40	2	19503830
Pubmed	LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.	LRP6 LRP5	1.29e-06	2	40	2	37202775
Pubmed	Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication.	LRP6 LRP5	1.29e-06	2	40	2	20926594
Pubmed	Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men.	LRP6 LRP5	1.29e-06	2	40	2	16355283
Pubmed	Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo.	LRP6 LRP5	1.29e-06	2	40	2	28425175
Pubmed	Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon.	LRP6 LRP5	3.87e-06	3	40	2	29602775
Pubmed	Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6.	LRP6 LRP5	3.87e-06	3	40	2	24412065
Pubmed	LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children.	LRP6 LRP5	3.87e-06	3	40	2	18721193
Pubmed	tPA regulates neurite outgrowth by phosphorylation of LRP5/6 in neural progenitor cells.	LRP6 LRP5	3.87e-06	3	40	2	23925701
Pubmed	Structural insight into the mechanisms of Wnt signaling antagonism by Dkk.	LRP6 LRP5	3.87e-06	3	40	2	18524778
Pubmed	Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.	LRP6 LRP5	3.87e-06	3	40	2	25710911
Pubmed	The structural basis of DKK-mediated inhibition of Wnt/LRP signaling.	LRP6 LRP5	3.87e-06	3	40	2	22589387
Pubmed	Wnt co-receptor LRP5/6 overexpression confers protection against hydrogen peroxide-induced neurotoxicity and reduces tau phosphorylation in SH-SY5Y cells.	LRP6 LRP5	3.87e-06	3	40	2	25959626
Pubmed	Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-catenin.	LRP6 LRP5	3.87e-06	3	40	2	27803037
Pubmed	Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.	LRP6 LRP5	3.87e-06	3	40	2	21397183
Pubmed	Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.	LRP6 LRP5	3.87e-06	3	40	2	22000856
Pubmed	Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts.	LRP6 LRP5	3.87e-06	3	40	2	18406176
Pubmed	Molecular simulation analysis of the structure complex of C2 domains of DKK family members and β-propeller domains of LRP5/6: explaining why DKK3 does not bind to LRP5/6.	LRP6 LRP5	3.87e-06	3	40	2	24743782
Pubmed	Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway.	LRP6 LRP5	3.87e-06	3	40	2	33650028
Pubmed	Lrp5 and Lrp6 play compensatory roles in mouse intestinal development.	LRP6 LRP5	3.87e-06	3	40	2	21866564
Pubmed	Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.	LRP6 LRP5	3.87e-06	3	40	2	30664649
Pubmed	Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation.	LRP6 LRP5	3.87e-06	3	40	2	22576936
Pubmed	Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease.	LRP6 LRP5	3.87e-06	3	40	2	25009587
Pubmed	TRAP1 Regulates Wnt/β-Catenin Pathway through LRP5/6 Receptors Expression Modulation.	LRP6 LRP5	3.87e-06	3	40	2	33065966
Pubmed	Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.	LRP6 LRP5	7.73e-06	4	40	2	22696217
Pubmed	Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function.	LRP6 LRP5	7.73e-06	4	40	2	21471202
Pubmed	Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin.	LRP6 LRP5	7.73e-06	4	40	2	26772978
Pubmed	The Wnt-β-Catenin-IL-10 Signaling Axis in Intestinal APCs Protects Mice from Colitis-Associated Colon Cancer in Response to Gut Microbiota.	LRP6 LRP5	7.73e-06	4	40	2	32917787
Pubmed	Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.	LRP6 LRP5	7.73e-06	4	40	2	29176883
Pubmed	Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.	LRP6 LRP5	7.73e-06	4	40	2	17002572
Pubmed	Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway.	LRP6 LRP5	7.73e-06	4	40	2	30361437
Pubmed	Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins.	LRP6 LRP5	7.73e-06	4	40	2	15064719
Pubmed	Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma.	LRP6 LRP5	7.73e-06	4	40	2	20846389
Pubmed	Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism.	LRP6 LRP5	7.73e-06	4	40	2	18502762
Pubmed	Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow.	LRP6 LRP5	7.73e-06	4	40	2	11433302
Pubmed	SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.	LRP6 LRP5	7.73e-06	4	40	2	15908424
Pubmed	Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition.	LRP6 LRP5	7.73e-06	4	40	2	23675479
Pubmed	Shh Plays an Inhibitory Role in Cusp Patterning by Regulation of Sostdc1.	LRP6 LRP5	7.73e-06	4	40	2	30325689
Pubmed	Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.	LRP6 LRP5	7.73e-06	4	40	2	31452509
Pubmed	Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation.	LRP6 LRP5	7.73e-06	4	40	2	18762581
Pubmed	The role of Lrp5/6 in cardiac valve disease: experimental hypercholesterolemia in the ApoE-/- /Lrp5-/- mice.	LRP6 LRP5	7.73e-06	4	40	2	21678468
Pubmed	Critical Endothelial Regulation by LRP5 during Retinal Vascular Development.	LRP6 LRP5	7.73e-06	4	40	2	27031698
Pubmed	Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.	ERBB2 ACACA	7.73e-06	4	40	2	17631500
Pubmed	Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.	LRP6 LRP5 ERBB2	8.23e-06	34	40	3	23293290
Pubmed	Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replication.	KAT7 KAT8	1.29e-05	5	40	2	17182677
Pubmed	Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling.	LRP6 LRP5	1.29e-05	5	40	2	24692544
Pubmed	Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.	LRP6 LRP5	1.29e-05	5	40	2	11448771
Pubmed	Analysis of association of LRP5, LRP6, SOST, DKK1, and CTNNB1 genes with bone mineral density in a Slovenian population.	LRP6 LRP5	1.29e-05	5	40	2	19898734
Pubmed	Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells.	LRP6 LRP5	1.29e-05	5	40	2	16805831
Pubmed	β-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation!	LRP6 LRP5	1.29e-05	5	40	2	24700412
Pubmed	TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer.	LRP6 LRP5	1.29e-05	5	40	2	31262711
Pubmed	The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage.	LRP6 LRP5	1.29e-05	5	40	2	19672307
Pubmed	Role and Regulation of p65/β-Catenin Association During Liver Injury and Regeneration: A "Complex" Relationship.	LRP6 LRP5	1.29e-05	5	40	2	28474571
Pubmed	Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation.	LRP6 LRP5	1.29e-05	5	40	2	16513652
Pubmed	Wnt/β-catenin signaling modulates corneal epithelium stratification via inhibition of Bmp4 during mouse development.	LRP6 LRP5	1.29e-05	5	40	2	26443636
Pubmed	Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation.	LRP6 LRP5	1.29e-05	5	40	2	27821587
Pubmed	A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.	LRP6 LRP5	1.29e-05	5	40	2	12121999
Pubmed	Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling.	LRP6 LRP5	1.29e-05	5	40	2	19107203
Pubmed	LDL-receptor-related proteins in Wnt signal transduction.	LRP6 LRP5	1.29e-05	5	40	2	11029007
Pubmed	Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling.	ERBB2 NRCAM	1.93e-05	6	40	2	23897819
Pubmed	N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation.	LRP6 LRP5	1.93e-05	6	40	2	19075000
Pubmed	Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer.	LRP6 LRP5	1.93e-05	6	40	2	27045006
Pubmed	Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function.	LRP6 LRP5	1.93e-05	6	40	2	37091972
Pubmed	Sfrp4 repression of the Ror2/Jnk cascade in osteoclasts protects cortical bone from excessive endosteal resorption.	LRP6 LRP5	1.93e-05	6	40	2	31239337
Pubmed	Novel lethal mouse mutants produced in balancer chromosome screens.	LRP6 ERBB2	1.93e-05	6	40	2	16466971
Pubmed	Macrophage Wnt7b is critical for kidney repair and regeneration.	LRP6 LRP5	1.93e-05	6	40	2	20160075
Pubmed	Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.	LRP6 LRP5 SFRP5	2.50e-05	49	40	3	19562671
Pubmed	Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.	LRP6 LRP5	2.70e-05	7	40	2	12857724
Pubmed	Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations.	LRP6 LRP5	2.70e-05	7	40	2	30713111
Pubmed	RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.	LRP6 LRP5	2.70e-05	7	40	2	34847079
Pubmed	Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase.	LRP6 LRP5	2.70e-05	7	40	2	28966723
Pubmed	The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo.	LRP6 LRP5	2.70e-05	7	40	2	19056682
Pubmed	Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.	LRP6 LRP5	2.70e-05	7	40	2	15923619
Pubmed	DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.	LRP6 LRP5	2.70e-05	7	40	2	29431745
Pubmed	Gut-liver axis calibrates intestinal stem cell fitness.	LRP6 LRP5	3.60e-05	8	40	2	38280375
Pubmed	Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.	LRP6 LRP5	3.60e-05	8	40	2	20093360
Pubmed	SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation.	LRP6 LRP5	3.60e-05	8	40	2	32820125
Pubmed	hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1.	KAT7 KAT8	3.60e-05	8	40	2	24126058
Pubmed	Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.	LRP6 LRP5	3.60e-05	8	40	2	15035989
Interaction	ODAPH interactions	LARGE2 LRP5 ACACA KIAA0232	2.14e-06	49	38	4	int:ODAPH
Cytoband	10q23.31	LIPF LIPJ	4.08e-04	34	40	2	10q23.31
GeneFamily	Low density lipoprotein receptors	LRP6 LRP5	1.79e-04	13	28	2	634
GeneFamily	Zinc fingers C2HC-type\|PHD finger proteins\|Lysine acetyltransferases	KAT7 KAT8	2.74e-04	16	28	2	66
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	KAT7 KAT8	3.10e-04	17	28	2	486
GeneFamily	Lipases\|Arylacetamide deacetylase family	LIPF LIPJ	5.24e-04	22	28	2	464
Coexpression	GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_UP	CRISPLD2 AMPD2 ANPEP HPSE ARAF	1.27e-05	199	40	5	M5357
Coexpression	YOSHIMURA_MAPK8_TARGETS_UP	SI BMP7 ERBB2 VTN CHKB NRCAM FOXA3 PCSK4 KRT36 ARAF	1.66e-05	1281	40	10	M1884
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Hs3st6\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BMP7 VTN OMD ANPEP	4.50e-06	123	40	4	64a2d7e40d9c948a9ccaf61c465fb2207e0b7ab8
ToppCell	primary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Col15a1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BMP7 VTN OMD ANPEP	7.96e-06	142	40	4	f4e4cde228149d5a536fbf0517ed71d81e296faf
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	MMP25 BMP7 OMD ANPEP	1.07e-05	153	40	4	e9c6fb5c41adb6595c66c3a917fe455348279e54
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	MMP25 BMP7 OMD ANPEP	1.07e-05	153	40	4	b8b5ff7d2feea3e3a352fb5530e49f639fe1ff88
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP\|Thalamus / BrainAtlas - Mouse McCarroll V32	MMP25 BMP7 OMD ANPEP	1.07e-05	153	40	4	2513edfae62a44e51d3556675a096723194c966c
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Col15a1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BMP7 VTN OMD ANPEP	1.24e-05	159	40	4	34c90711c5857cf6ada7b3acff99f1d48c7caf29
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP\|Hippocampus / BrainAtlas - Mouse McCarroll V32	BMP7 VTN OMD ANPEP	1.54e-05	168	40	4	26aa96b2b547d11941cb803995ea3d302ee0518c
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BMP7 VTN OMD ANPEP	1.54e-05	168	40	4	9930bd63b60c03f0152838a79eef77da1c2dd8e5
ToppCell	healthy_donor-Myeloid-Monocytic-Neutrophil\|healthy_donor / Disease condition, Lineage, Cell class and subclass	MMP25 CRISPLD2 NCF4 ANPEP	1.54e-05	168	40	4	04259f5a9b067cd1b5619e34591e4b2fccc18535
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LIPF LARGE2 BMP7 NRCAM	1.62e-05	170	40	4	2d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LIPF LARGE2 BMP7 NRCAM	1.62e-05	170	40	4	0cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BMP7 VTN OMD ANPEP	1.65e-05	171	40	4	2e43fb129ee9bdc3b31febc43c10f959bf0f4a7d
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BMP7 VTN OMD ANPEP	1.65e-05	171	40	4	e219a1aa59a96e4bc3e2eacf985679174a51de41
ToppCell	primary_visual_cortex-Non-neuronal-leptomeningeal_cell\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BMP7 VTN OMD ANPEP	1.77e-05	174	40	4	2891ab2fd05eb4bbd239d1a2865f21ef7f2df39e
ToppCell	primary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BMP7 VTN OMD ANPEP	1.77e-05	174	40	4	eade55f86ef1f7a5355ad65cec3aa6bfc5d3c62d
ToppCell	primary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BMP7 VTN OMD ANPEP	1.89e-05	177	40	4	599cf7f5b774e197a1b43c98e4b9a8c1a618f38a
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CRISPLD2 BMP7 OMD KRT36	2.07e-05	181	40	4	6730e249cac55ae892cc567d9211615882f3dab4
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CRISPLD2 BMP7 OMD KRT36	2.07e-05	181	40	4	3462aa1c08fbaf613b6278ab2c7a5a0940bf537d
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ERBB2 SFRP5 ACACA KIAA0232	2.40e-05	188	40	4	c2febf9fd4632af1f922067c3a30e5c50f75f480
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDIT4L CRISPLD2 VTN ANPEP	2.55e-05	191	40	4	cb75e6c36dbe2e091e407d691c063ec7c4fd5f90
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDIT4L CRISPLD2 VTN ANPEP	2.55e-05	191	40	4	b2cffea7860dd590b505ee0ebd51aa1978cb5e64
ToppCell	Hippocampus-Endothelial\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CRISPLD2 VTN OMD ANPEP	2.60e-05	192	40	4	36deadab892d3e639a71f33697bb2d3cbbaa5372
ToppCell	mild-Lymphocytic-CD4_T_cells_2\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MMP25 CRISPLD2 NCF4 ANPEP	2.60e-05	192	40	4	4cd8f572e067bf5fe22f62fa868d7d332f097a8c
ToppCell	PBMC-Severe-cDC_0\|Severe / Compartment, Disease Groups and Clusters	CRISPLD2 ANPEP HPSE KIAA0232	2.60e-05	192	40	4	4f4774b925058191673b4ba4b4d05b8b37f61795
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDIT4L CRISPLD2 VTN ANPEP	2.60e-05	192	40	4	e5117cdb8af220f60bd1410262078c0306667b4a
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRISPLD2 AMPD2 NDUFB9 KIAA0232	2.66e-05	193	40	4	fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCell	Control-CD8+_T_naive\|Control / Disease condition and Cell class	NBEA SFRP5 NRCAM RIC3	2.66e-05	193	40	4	627d345baf1940218c61907305705298e473dbab
ToppCell	severe-Myeloid-Neutrophils_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MMP25 CRISPLD2 NCF4 ANPEP	2.66e-05	193	40	4	f4d43dfbf4115dd0f843ea5cf08049220342a047
ToppCell	control-Myeloid-Neutrophils_3\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MMP25 CRISPLD2 NCF4 ANPEP	2.66e-05	193	40	4	56daf3c59a124dd068af5409113913d9ee81a454
ToppCell	control-Lymphocytic-CD4_T_cells_2\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MMP25 CRISPLD2 NCF4 ANPEP	2.71e-05	194	40	4	c2ae2ea848d78725455dcb6be9f1d8933745fa80
ToppCell	control-Myeloid-Neutrophils_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MMP25 CRISPLD2 NCF4 ANPEP	2.71e-05	194	40	4	2218e6677dc6781a6e4ef3a315f2298cc2cd9df2
ToppCell	severe-Myeloid-Neutrophils_3\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MMP25 CRISPLD2 NCF4 ANPEP	2.71e-05	194	40	4	1f8edab1c8ba48bc0114429ea47aab378b5830b7
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Pcdh11x\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MMP25 SFRP5 HPSE	2.74e-05	65	40	3	d90513969c0147c48403ce0155580a97f44ba716
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Pcdh11x-Inhibitory_Neuron.Gad1Gad2_Sst.Pcdh11x_(Interneuron,_OLM4_(Dentate_enriched?))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MMP25 SFRP5 HPSE	2.74e-05	65	40	3	d6ad7b63bc09fdc05a1245bf66d3c5a46e622ba5
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Pcdh11x-Inhibitory_Neuron.Gad1Gad2_Sst.Pcdh11x_(Interneuron,_OLM4_(Dentate_enriched?))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MMP25 SFRP5 HPSE	2.74e-05	65	40	3	f7f4560363bacad033154a402d7593aa5ebfb2e7
ToppCell	(3)_Chondrocytes-(30)_Chondro\|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis	DDIT4L SFRP5 OMD NRCAM	2.77e-05	195	40	4	f5597d3ed37770c6fa2b339f98a80ac7ecd4f9ff
ToppCell	mild-Myeloid-Neutrophils_3\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MMP25 CRISPLD2 NCF4 ANPEP	2.77e-05	195	40	4	a1cfed0092debcc003eff6a62508556b7664d5e1
ToppCell	mild-Myeloid-Neutrophils_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MMP25 CRISPLD2 NCF4 ANPEP	2.82e-05	196	40	4	9c351306b6aae68ed47d4cb1911957bf67f9e1ae
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CRISPLD2 BMP7 SFRP5 NRCAM	2.82e-05	196	40	4	671c380b58d7f634b4fbec38c357d357ea4f3535
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CRISPLD2 BMP7 SFRP5 NRCAM	2.82e-05	196	40	4	f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCell	3'-Adult-SmallIntestine\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SI SFRP5 ANPEP RIC3	2.88e-05	197	40	4	1614bc5f41fd2c8385e58ed6b87ef1536421f29a
ToppCell	(3)_Chondrocytes-(30)_Chondro\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	DDIT4L BMP7 SFRP5 OMD	2.88e-05	197	40	4	a07ab2564ca7d577fd47f444dd7b0c25556e9fc4
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SI VTN ANPEP FOXA3	2.94e-05	198	40	4	8fbc461315986e357a0961a261ed10880637d6ad
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SI SFRP5 ANPEP FOXA3	3.05e-05	200	40	4	eef5f6bd9ff5d985def8befcf45786234317f144
ToppCell	Substantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DDIT4L VTN ANPEP	1.70e-04	120	40	3	3e1ae5a5422729d484a90d72f779833fe3473fa8
ToppCell	Substantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DDIT4L VTN ANPEP	1.70e-04	120	40	3	24d5e86931a857bb87684392172bf04294a1a46a
ToppCell	Substantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DDIT4L VTN ANPEP	1.70e-04	120	40	3	e60b74758c8290919b326904ad841962256b72ec
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Agt_(Agt)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	BMP7 OMD ANPEP	2.41e-04	135	40	3	4cb399620aa9edc2ca59e4df76ab7011ceb58db9
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	BMP7 OMD ANPEP	2.41e-04	135	40	3	6bd2a0bfd8d20950f1b66810668682dc055a0ada
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	BMP7 OMD ANPEP	2.41e-04	135	40	3	7e3559ed0fef7916d1938b4e1a9fa4456a60e3d3
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Agt_(Agt)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	BMP7 OMD ANPEP	2.41e-04	135	40	3	97989546826bf3739e1b86a10832a457fd37c5d2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DDIT4L OMD L3MBTL2	3.34e-04	151	40	3	ea62e92ccb984f44559b434f35c1c4450767c8f1
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CRISPLD2 CHKB NRCAM	3.41e-04	152	40	3	621e9b33cd3bb1c7b7d0633069f286b203e3d9c0
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	BMP7 OMD ANPEP	3.47e-04	153	40	3	151c469b26f9adf04dd6f117f03bef760cc3d45d
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	BMP7 OMD ANPEP	3.54e-04	154	40	3	65dbb60f636562eeba3dafadae9c0c7db2b27476
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACA L3MBTL2 KIAA0232	3.82e-04	158	40	3	1d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALG8 NCF4 HPSE	3.82e-04	158	40	3	ad1040bce6ad655c2502d9abb02507ecff177f83
ToppCell	Healthy/Control-CD8+_T_naive\|World / Disease group and Cell class	SFRP5 NRCAM RIC3	3.82e-04	158	40	3	70680b29428b6bf882b1fae36f924b775961176b
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALG8 NCF4 HPSE	3.82e-04	158	40	3	ac7aef01eda1dca80d6c5b508649fcad55803a67
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	BMP7 VTN OMD	3.89e-04	159	40	3	cb2470b288c13e454a2a80115b0d5613b3f718e6
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	BMP7 OMD ANPEP	3.89e-04	159	40	3	92049a8d8fc9997d8d0d76500c72596a9b2394e0
ToppCell	Healthy/Control-CD8+_T_naive\|Healthy/Control / Disease group and Cell class	SFRP5 NRCAM RIC3	3.96e-04	160	40	3	e1386c21fcbbf57fa32d8bdfba3cb1887477ff73
ToppCell	Healthy_donor-CD8+_T_naive\|World / disease group, cell group and cell class (v2)	SFRP5 NRCAM RIC3	4.03e-04	161	40	3	8a61395af33132783a0a37956c6f821aba5d3b1e
ToppCell	TCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Seminoma-_NOS-5\|TCGA-Testes / Sample_Type by Project: Shred V9	DDIT4L NRCAM L3MBTL2	4.18e-04	163	40	3	80bc3732afd8501938753120b8403098c7c5e928
ToppCell	TCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Seminoma-_NOS\|TCGA-Testes / Sample_Type by Project: Shred V9	DDIT4L NRCAM L3MBTL2	4.18e-04	163	40	3	67551fefe22bd5b8178fa248fed2a6c17b19fb0f
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3\|Striatum / BrainAtlas - Mouse McCarroll V32	CRISPLD2 VTN OMD	4.25e-04	164	40	3	e24b06a14565f7798ac50c2fe3f34d4547b9000e
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CRISPLD2 BMP7 OMD	4.33e-04	165	40	3	570483b43ccb5831feec9337b4664814431d40b1
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CRISPLD2 BMP7 OMD	4.33e-04	165	40	3	2026a9a07f4d314cc05c167e491312b373468e46
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	BMP7 VTN SFRP5	4.33e-04	165	40	3	5e7ee76f3dcddbd1b560bacd043f9001b0c18b5f
ToppCell	Control-Myeloid-MoAM1,_IL1R2\|Control / Condition, Lineage and Cell class	MMP25 CRISPLD2 HPSE	4.49e-04	167	40	3	ab6029ba037b6a499da8758864c44e174cde5587
ToppCell	Adult-Mesenchymal-myofibroblast_cell\|Adult / Lineage, Cell type, age group and donor	OMD NRCAM SEMA4C	4.49e-04	167	40	3	d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCell	Control-Myeloid-MoAM1,_IL1R2\|Myeloid / Condition, Lineage and Cell class	MMP25 CRISPLD2 HPSE	4.49e-04	167	40	3	6e5140527437193f441ca96893b9a00d346614f3
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DDIT4L OMD FOXA3	4.49e-04	167	40	3	102b3d160a44c8623fab1fd10e9054178c42a78b
ToppCell	ASK428-Immune-Mast_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	NBEA SFRP5 NRCAM	4.56e-04	168	40	3	c399fcb4d1d0be48026c2ecabc34a5935e7adf73
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	OMD FOXA3 PCSK4	4.64e-04	169	40	3	58e22f9119240664515fe91ca53812611a8f17d6
ToppCell	Healthy_donor-CD8+_T_naive\|Healthy_donor / disease group, cell group and cell class (v2)	SFRP5 NRCAM RIC3	4.64e-04	169	40	3	66216758e581365f10c2a66714d83a606ad23af0
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SFRP5 OMD ANPEP	4.64e-04	169	40	3	031465190cd3623a25ef2b868daab8d932c8ff08
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SFRP5 OMD ANPEP	4.81e-04	171	40	3	15cb4670ff4234ac46aea8a5911138d6913c4482
ToppCell	COVID-19-kidney-PEC\|kidney / Disease (COVID-19 only), tissue and cell type	CRISPLD2 BMP7 SACS	4.89e-04	172	40	3	36a96714a0eb6ac438648135336c9791881ddadb
ToppCell	droplet-Liver-nan-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDIT4L LRP6 RIC3	4.89e-04	172	40	3	1f335ccb92b22d0412954e8fc3af212f96410b67
ToppCell	droplet-Liver-nan-3m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDIT4L LRP6 RIC3	4.89e-04	172	40	3	bb96c896d125e10b71e94e2bdad243899045af5c
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRISPLD2 VTN ANPEP	4.97e-04	173	40	3	2acd0693a2dfe04e3c1b2125ea63efe92d13150b
ToppCell	11.5-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	DDIT4L SFRP5 RIC3	4.97e-04	173	40	3	6989c9cebcd81eccceac7e5a86152676ee959386
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRISPLD2 VTN ANPEP	4.97e-04	173	40	3	2415b6ff49f334da570577d4e93484d024a3dbd5
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DDIT4L CRISPLD2 SACS	5.23e-04	176	40	3	4ed73c73972334f6dc4229920205547823252fa0
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DDIT4L OMD FOXA3	5.23e-04	176	40	3	77c3da2eaa072a6baefb5087fd07ec18c5e271cd
ToppCell	droplet-Kidney-nan-18m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRISPLD2 NBEA SFRP5	5.23e-04	176	40	3	533d544852038c0612aacf87f4b1c88ff7aace82
ToppCell	343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	CRISPLD2 OMD NRCAM	5.23e-04	176	40	3	2e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell	343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|343B / Donor, Lineage, Cell class and subclass (all cells)	CRISPLD2 OMD NRCAM	5.23e-04	176	40	3	f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CRISPLD2 NBEA OMD	5.31e-04	177	40	3	bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell	droplet-Fat-SCAT-30m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP5 OMD NRCAM	5.40e-04	178	40	3	5cf12927f0756c4d8a289fe4308d736382e6212e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRISPLD2 VTN ANPEP	5.40e-04	178	40	3	7467e5ab2fcb39cc4a2c7dd69722c91def3b6aea
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	BMP7 OMD ANPEP	5.40e-04	178	40	3	cda7695411655bd6d0ba69e5041ca7530a9dad3a
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	VTN FOXA3 RIC3	5.49e-04	179	40	3	06f92c884189197c86793191c05f65e34925c097
ToppCell	normal_Pleural_Fluid-Myeloid_cells-CD141+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	DDIT4L OMD ANPEP	5.58e-04	180	40	3	a0b35067b6f2dbd8145da8bab760e9f650f045b0
ToppCell	Neuroendocrine-neuroendo-1\|World / Class top	VTN SFRP5 CHKB	5.58e-04	180	40	3	50fdd182a083380899b5943cb5f55ffd77e2a7d4
ToppCell	facs-SCAT\|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP7 HPSE KRT36	5.58e-04	180	40	3	6c70b6b7480507fa94625013222ad338ee7dd1d9
ToppCell	Mesenchymal_cells-Stromal_fibro.\|Mesenchymal_cells / Lineage and Cell class	CRISPLD2 BMP7 VTN	5.67e-04	181	40	3	f8d914fdc06aaa75a4dc9158daf574ca28fa5432
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic-Megakaryocytic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRP5 SFRP5 PCSK4	5.67e-04	181	40	3	14c2dd946e89ba578711c2d25935b6b3d319b701
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRP5 SFRP5 PCSK4	5.67e-04	181	40	3	9dc0563453e24c9d1d975e2e0e1e272487e19908
Drug	NSC90351	SI ANPEP	8.57e-06	3	39	2	CID000259791
Drug	AC1L1COZ	KAT7 ACACA CHKB KAT8	1.69e-05	90	39	4	CID000001996
Drug	Methacycline hydrochloride [3963-95-9]; Up 200; 8.4uM; HL60; HT_HG-U133A	MMP25 BMP7 NBEA KAT8 SEMA4C	2.14e-05	198	39	5	2901_UP
Drug	fredericamycin A	ACACA ARAF	2.85e-05	5	39	2	CID005384075
Drug	R1128C	ACACA ARAF	2.85e-05	5	39	2	CID000195787
Disease	choline/ethanolamine kinase measurement	VTN CHKB	1.02e-05	4	39	2	EFO_0021935
Disease	polycystic liver disease (is_implicated_in)	LRP5 ALG8	1.70e-05	5	39	2	DOID:0050770 (is_implicated_in)
Disease	Polycystic liver disease	LRP5 ALG8	1.70e-05	5	39	2	C0158683
Disease	growth/differentiation factor 5 measurement	VTN ANPEP	2.54e-05	6	39	2	EFO_0020429
Disease	Mammary Carcinoma, Human	ERBB2 SFRP5 NRCAM HPSE ARAF	6.11e-04	525	39	5	C4704874
Disease	Mammary Neoplasms, Human	ERBB2 SFRP5 NRCAM HPSE ARAF	6.11e-04	525	39	5	C1257931
Disease	Mammary Neoplasms	ERBB2 SFRP5 NRCAM HPSE ARAF	6.22e-04	527	39	5	C1458155
Disease	Breast Carcinoma	ERBB2 SFRP5 NRCAM HPSE ARAF	6.83e-04	538	39	5	C0678222
Disease	fatty liver disease (implicated_via_orthology)	LRP6 ACACA	7.73e-04	31	39	2	DOID:9452 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
AFDNLYYWDQDPPER	ERBB2	1216	P04626
VAWVDPEDPYKGYRY	ACACA	1736	Q13085
DFDYWDYVVPEPNLN	DDIT4L	31	Q96D03
YVEYLGADYAEPTWN	ANPEP	416	P15144
EAWVEEDNPPYAYYL	AMPD2	646	Q01433
YDYTHEEWPFYKARP	CHKB	286	Q9Y259
DWIIAPEGYAAYYCE	BMP7	346	P18075
APYRVQWAANYEPYV	LARGE2	606	Q8N3Y3
YWRYDEAAARPDPGY	MMP25	436	Q9NPA2
ELDTWYHSPYPEEYA	KAT7	346	O95251
DQVAMPYQWEYPYLL	JAGN1	66	Q8N5M9
WEYEGPEHVNFYVEY	NRCAM	1086	Q92823
EYDQWVDCESPDIYP	L3MBTL2	576	Q969R5
NYEIDAWYFSPFPED	KAT8	186	Q9H7Z6
IISYWGYPDEEYDIV	LIPJ	6	Q5W064
IAIDYDPLEGYVYWT	LRP5	376	O75197
YWGYPNEEYEVVTED	LIPF	41	P07098
PDLWANYDPLASYDF	PCSK4	166	Q6UW60
YKEEPLWYTEPIAEY	KIAA0232	396	Q92628
WYDEVKDYTYPYPSE	CRISPLD2	131	Q9H0B8
PEEDDPTNWLRCYYY	NCF4	231	Q15080
DYDPVEGYIYWTDDE	LRP6	366	O75581
APYMEDWEGYPEETY	RIC3	216	Q7Z5B4
DWEGYPEETYPIYDL	RIC3	221	Q7Z5B4
YHLVDENFDPLPDYW	HPSE	391	Q9Y251
YRDSGYYWEVPPSEV	ARAF	296	P10398
DPYDLYFYAPDTWVP	GFY	461	I3L273
ELMDYTYYAVWPDPD	SACS	1936	Q9NZJ4
QEWYEFQIPYICPDY	KRT36	126	O76013
YENDDQLLWDPEYLP	MIER1	206	Q8N108
QYETYQWDEDYDQEP	OMD	21	Q99983
PARCEEYDYYGWQAE	SFRP5	26	Q5T4F7
REGIDPTPYYWYTDQ	NARS1	491	O43776
EAEEEFWYRQHPQPY	NDUFB9	66	Q9Y6M9
DLAEWSYYPEAGEVY	FOXA3	11	P55318
RYETWEDDQSPPYHY	NBEA	2361	Q8NFP9
DYPDALITNYYLWPA	MPV17	126	P39210
DTVSAYIPDAIWYDY	SI	751	P14410
PDEKLWDPVGYYYSD	SEMA4C	726	Q9C0C4
YYEATSEWTLDYPPF	ALG8	56	Q9BVK2
QYWRFEDGVLDPDYP	VTN	226	P04004