Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF35 ZNF670 ZNF883 ZNF354B	2.89e-04	1412	39	10	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF35 ZNF670 ZNF883 ZNF354B	3.76e-04	1459	39	10	GO:0000977
GeneOntologyBiologicalProcess	negative regulation of catabolic process	TRIM39 ADRA1A RGP1 WDR6 ALK TENT2 TMEM132A LRRK2	9.44e-07	418	39	8	GO:0009895
GeneOntologyBiologicalProcess	thioester metabolic process	FITM2 PDHB TECR ACSS1	5.26e-05	109	39	4	GO:0035383
GeneOntologyBiologicalProcess	acyl-CoA metabolic process	FITM2 PDHB TECR ACSS1	5.26e-05	109	39	4	GO:0006637
GeneOntologyBiologicalProcess	thioester biosynthetic process	PDHB TECR ACSS1	1.08e-04	49	39	3	GO:0035384
GeneOntologyBiologicalProcess	acyl-CoA biosynthetic process	PDHB TECR ACSS1	1.08e-04	49	39	3	GO:0071616
GeneOntologyBiologicalProcess	purine nucleoside bisphosphate metabolic process	FITM2 PDHB TECR ACSS1	1.47e-04	142	39	4	GO:0034032
GeneOntologyBiologicalProcess	nucleoside bisphosphate metabolic process	FITM2 PDHB TECR ACSS1	1.47e-04	142	39	4	GO:0033865
GeneOntologyBiologicalProcess	ribonucleoside bisphosphate metabolic process	FITM2 PDHB TECR ACSS1	1.47e-04	142	39	4	GO:0033875
GeneOntologyBiologicalProcess	regulation of dopamine receptor signaling pathway	ALK LRRK2	1.90e-04	11	39	2	GO:0060159
GeneOntologyBiologicalProcess	ribonucleoside bisphosphate biosynthetic process	PDHB TECR ACSS1	2.08e-04	61	39	3	GO:0034030
GeneOntologyBiologicalProcess	purine nucleoside bisphosphate biosynthetic process	PDHB TECR ACSS1	2.08e-04	61	39	3	GO:0034033
GeneOntologyBiologicalProcess	nucleoside bisphosphate biosynthetic process	PDHB TECR ACSS1	2.08e-04	61	39	3	GO:0033866
GeneOntologyBiologicalProcess	fatty acid derivative metabolic process	FITM2 ALOX5 TECR	4.99e-04	82	39	3	GO:1901568
GeneOntologyCellularComponent	aminoacyl-tRNA synthetase multienzyme complex	AIMP2 QARS1	2.33e-04	12	40	2	GO:0017101
MousePheno	increased renal glomerulus apoptosis	CCNI LRRK2	6.95e-05	7	26	2	MP:0011369
Domain	zf-C2H2_6	ZNF8 ZNF320 ZNF680 ZNF354A ZNF560 ZNF670 ZNF883 ZNF354B	2.81e-07	314	40	8	PF13912
Domain	KRAB	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF670 ZNF354B	7.59e-07	358	40	8	PS50805
Domain	KRAB	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF670 ZNF354B	7.59e-07	358	40	8	PF01352
Domain	KRAB	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF670 ZNF354B	9.53e-07	369	40	8	SM00349
Domain	KRAB	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF670 ZNF354B	9.72e-07	370	40	8	IPR001909
Domain	-	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF35 ZNF670 ZNF883 ZNF354B	1.19e-06	679	40	10	3.30.160.60
Domain	zf-C2H2	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF35 ZNF670 ZNF883 ZNF354B	1.43e-06	693	40	10	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF35 ZNF670 ZNF883 ZNF354B	1.45e-06	694	40	10	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF35 ZNF670 ZNF883 ZNF354B	3.90e-06	775	40	10	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF35 ZNF670 ZNF883 ZNF354B	3.99e-06	777	40	10	PS00028
Domain	Znf_C2H2-like	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF35 ZNF670 ZNF883 ZNF354B	4.95e-06	796	40	10	IPR015880
Domain	Znf_C2H2	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF35 ZNF670 ZNF883 ZNF354B	5.47e-06	805	40	10	IPR007087
Domain	ZnF_C2H2	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF35 ZNF670 ZNF883 ZNF354B	5.65e-06	808	40	10	SM00355
Domain	ARM_REPEAT	JUP NEK10 ANKAR	8.51e-05	40	40	3	PS50176
Domain	zf-C2H2_11	ZNF354A ZNF354B	1.59e-04	9	40	2	PF16622
Domain	ARM-type_fold	JUP UPF2 NEK10 ANKAR LRRK2	7.47e-04	339	40	5	IPR016024
Domain	Quino_amine_DH_bsu	WDR6 LRRK2	1.01e-03	22	40	2	IPR011044
Domain	-	JUP NEK10 ANKAR LRRK2	1.27e-03	222	40	4	1.25.10.10
Domain	Arm	JUP ANKAR	2.00e-03	31	40	2	PF00514
Domain	ARM-like	JUP NEK10 ANKAR LRRK2	2.59e-03	270	40	4	IPR011989
Domain	ARM	JUP ANKAR	3.31e-03	40	40	2	SM00185
Domain	Armadillo	JUP ANKAR	4.55e-03	47	40	2	IPR000225
Domain	Quinoprotein_ADH-like_supfam	WDR6 PWP2	5.75e-03	53	40	2	IPR011047
Domain	Protein_kinase_ATP_BS	NEK10 ALK CDK3 LRRK2	8.57e-03	379	40	4	IPR017441
Domain	PROTEIN_KINASE_ATP	NEK10 ALK CDK3 LRRK2	1.64e-02	459	40	4	PS00107
Domain	PROTEIN_KINASE_TYR	NEK10 ALK	1.83e-02	97	40	2	PS00109
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF670 ZNF354B	1.48e-09	181	40	7	37372979
Pubmed	Characterization of the mouse Kid1 gene and identification of a highly related gene, Kid2.	ZNF354A ZNF354B	1.29e-06	2	40	2	10564808
Pubmed	Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents.	AIMP2 QARS1	3.60e-05	8	40	2	1651330
Pubmed	Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases.	AIMP2 QARS1	3.60e-05	8	40	2	10913161
Pubmed	The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase.	AIMP2 QARS1	5.77e-05	10	40	2	8188258
Pubmed	The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex.	AIMP2 QARS1	5.77e-05	10	40	2	16055448
Pubmed	The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function.	AIMP2 QARS1	5.77e-05	10	40	2	11714285
Pubmed	Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit.	AIMP2 QARS1	5.77e-05	10	40	2	8052601
Pubmed	Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer.	AIMP2 QARS1	5.77e-05	10	40	2	8078941
Pubmed	Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant.	AIMP2 QARS1	5.77e-05	10	40	2	9278442
Pubmed	Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells.	AIMP2 QARS1	7.05e-05	11	40	2	19289464
Pubmed	Expression of human aspartyl-tRNA synthetase in Escherichia coli. Functional analysis of the N-terminal putative amphiphilic helix.	AIMP2 QARS1	7.05e-05	11	40	2	8449960
Pubmed	Dissection of the structural organization of the aminoacyl-tRNA synthetase complex.	AIMP2 QARS1	7.05e-05	11	40	2	19131329
Pubmed	Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein.	AIMP2 QARS1	9.98e-05	13	40	2	9878398
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	AIMP2 ALOX5 SGSM2 PWP2	1.07e-04	214	40	4	22199357
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	AIMP2 UPF2 QARS1 PDHB TENT2 TECR ACSS1 PWP2	1.09e-04	1318	40	8	30463901
Pubmed	p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance.	AIMP2 QARS1	1.16e-04	14	40	2	12060739
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	JUP AIMP2 QARS1 PDHB WDR6 TECR	1.69e-04	725	40	6	27025967
Pubmed	Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.	AIMP2 QARS1 PDHB TECR	2.13e-04	256	40	4	35777956
Pubmed	Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis.	JUP WDR6 PWP2	3.35e-04	117	40	3	34662580
Pubmed	LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.	JUP ZNF354A AIMP2 QARS1 TECR	5.15e-04	580	40	5	35676659
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	JUP AIMP2 UPF2 QARS1 WDR6 TECR PWP2	5.19e-04	1257	40	7	36526897
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	AIMP2 QARS1 PDHB TECR PWP2	7.91e-04	638	40	5	33239621
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	AIMP2 UPF2 QARS1 PDHB TECR PWP2	7.95e-04	971	40	6	33306668
Pubmed	Association of gene polymorphisms with chronic kidney disease in Japanese individuals.	ALOX5 ACSS1	9.30e-04	39	40	2	19724895
Interaction	TRMT1 interactions	JUP AIMP2 QARS1 WDR6 PWP2	6.29e-06	140	38	5	int:TRMT1
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	ZNF35 QARS1 WDR6	2.64e-03	316	40	3	chr3p21
Cytoband	5q35.3	ZNF354A ZNF354B	3.14e-03	95	40	2	5q35.3
Cytoband	3p21.31	QARS1 WDR6	3.47e-03	100	40	2	3p21.31
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF8 ZNF74 ZNF320 ZNF680 ZNF354A ZNF560 ZNF35 ZNF670 ZNF883 ZNF354B	2.67e-07	718	32	10	28
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	JUP ANKAR	2.62e-03	43	32	2	409
Disease	Papillary Renal Cell Carcinoma	PDHB ALK ALOX5 LRRK2	2.22e-05	128	38	4	C1306837
Disease	Renal Cell Carcinoma	PDHB ALK ALOX5 LRRK2	2.22e-05	128	38	4	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	PDHB ALK ALOX5 LRRK2	2.22e-05	128	38	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	PDHB ALK ALOX5 LRRK2	2.22e-05	128	38	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	PDHB ALK ALOX5 LRRK2	2.22e-05	128	38	4	C1266044
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	PDHB ALK ALOX5 LRRK2	3.93e-05	148	38	4	C0279702
Disease	in situ carcinoma (is_marker_for)	ZNF354A ALOX5	3.34e-04	21	38	2	DOID:8719 (is_marker_for)
Disease	seminoma (is_marker_for)	JUP ZNF354A	3.67e-04	22	38	2	DOID:4440 (is_marker_for)
Disease	Ovarian Serous Adenocarcinoma	ALK LRRK2	4.02e-04	23	38	2	C1335177
Disease	Ovarian Mucinous Adenocarcinoma	NEK10 LRRK2	7.33e-04	31	38	2	C1335167
Disease	unipolar depression, sex interaction measurement	ADAM29 JUP	1.98e-03	51	38	2	EFO_0003761, EFO_0008343
Disease	pulmonary hypertension (biomarker_via_orthology)	ALOX5 GPR182	4.79e-03	80	38	2	DOID:6432 (biomarker_via_orthology)
Disease	cancer (implicated_via_orthology)	JUP ALK CDK3	4.94e-03	268	38	3	DOID:162 (implicated_via_orthology)
Disease	conotruncal heart malformations	ADAM29 ALK	9.50e-03	114	38	2	MONDO_0016581

Protein segments in the cluster

Peptide	Gene	Start	Entry
IDHICIHRHCVHITI	ADAM29	606	Q9UKF5
HCPTVQHVLVAHRTD	ACSS1	241	Q9NUB1
LVILSVACHRHLHSV	ADRA1A	46	P35348
LIHCRELVAHHLSTL	CCNI	236	Q14094
RHILTLVHKHFCTRL	TENT2	236	Q6PIY7
IFHHAALHNRVSIIC	ANKAR	536	Q7Z5J8
HITVVSHSRPVGHCL	PDHB	236	P11177
RNTVTCHHELAVLSH	NEK10	821	Q6ZWH5
LVVLCHLHHPSLISL	LRRK2	1921	Q5S007
HHVVSHFTCKILAVL	OR13J1	171	Q8NGT2
TARCTTSILHNLSHH	JUP	201	P14923
LLQGVSFCHSHRVIH	CDK3	111	Q00526
SVLHEVKTDRSHCLH	FITM2	171	Q8N6M3
RESHCSIHRHTVVKL	CENPM	106	Q9NSP4
SHTHVSVVISFCRHC	UPF2	301	Q9HAU5
THCLCDSIEHITHSL	QARS1	441	P47897
SLSHVAHLRICITHV	UBOX5	166	O94941
CLICAISHTHRAHTV	TRIM39	126	Q9HCM9
HHTTLITCHRAGLTE	TMEM132A	321	Q24JP5
HVHQTITHLLRTHLV	ALOX5	361	P09917
VSHVTHARHQESCLH	RGP1	281	Q92546
LDTVRSICHHSHKRL	ARHGAP17	36	Q68EM7
LTLHGTHISLHCHLV	GPR182	281	O15218
HCRHLSTVRTHLSAL	SGSM2	506	O43147
STVRTHLSALVHHSV	SGSM2	511	O43147
SSEHCTLAVSVHRHL	ALK	341	Q9UM73
LLCEHFRVLSTVHTH	AIMP2	141	Q13155
CFSHLIVHQRIHTAE	ZNF35	401	P13682
SCKSHLEIHRIIHTG	ZNF320	171	A2RRD8
LVSLVCRSVLHHFHF	PWP2	81	Q15269
SSRHTVVHLACICHS	TECR	121	Q9NZ01
SRLACHVMHLSSHRL	WDR6	826	Q9NNW5
SFCHSTHLTVHRRIH	ZNF8	321	P17098
CHSSLIVHQRIHTGE	ZNF74	511	Q16587
RSTHLTEHLKIHSCV	ZNF883	276	P0CG24
ALSSHSTLIIHERIH	ZNF354A	446	O60765
HSASLCKHLRTHTVE	ZNF354B	281	Q96LW1
ALSSHSTLIIHERIH	ZNF354B	446	Q96LW1
FCMLSHLTQHIRIHT	ZNF680	191	Q8NEM1
IISVHCMHILVRCSH	SLC36A4	101	Q6YBV0
FTCHSDLTNHVRIHT	ZNF560	721	Q96MR9
VFICHSALHRHILSH	ZNF670	111	Q9BS34