Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Neoplasm of the middle ear	FOCAD COG1 APC2	1.11e-05	12	20	3	HP:0100799
HumanPheno	Cholesteatoma	FOCAD COG1 APC2	1.11e-05	12	20	3	HP:0009797
Domain	ARM-type_fold	FOCAD PPP4R1 WAPL NBEAL1 MROH2A APC2 RTTN NUP188 AGBL1	4.22e-07	339	53	9	IPR016024
Domain	Myosin_N	MYH1 MYH4	8.10e-04	15	53	2	IPR004009
Domain	Myosin_N	MYH1 MYH4	8.10e-04	15	53	2	PF02736
Domain	ARM-like	PPP4R1 MROH2A APC2 RTTN AGBL1	9.91e-04	270	53	5	IPR011989
Domain	Myosin_tail_1	MYH1 MYH4	1.17e-03	18	53	2	PF01576
Domain	Myosin_tail	MYH1 MYH4	1.17e-03	18	53	2	IPR002928
Domain	Leu-rich_rpt_Cys-con_subtyp	RNH1 KDM2A	1.31e-03	19	53	2	IPR006553
Domain	Myosin-like_IQ_dom	MYH1 MYH4	1.31e-03	19	53	2	IPR027401
Domain	-	MYH1 MYH4	1.31e-03	19	53	2	4.10.270.10
Domain	LRR_CC	RNH1 KDM2A	1.31e-03	19	53	2	SM00367
Domain	ATPase_P-typ_transduc_dom_A	ATP11B TMEM94	4.94e-03	37	53	2	IPR008250
Domain	E1-E2_ATPase	ATP11B TMEM94	4.94e-03	37	53	2	PF00122
Domain	MYOSIN_MOTOR	MYH1 MYH4	5.20e-03	38	53	2	PS51456
Domain	Myosin_head	MYH1 MYH4	5.20e-03	38	53	2	PF00063
Domain	Myosin_head_motor_dom	MYH1 MYH4	5.20e-03	38	53	2	IPR001609
Domain	MYSc	MYH1 MYH4	5.20e-03	38	53	2	SM00242
Pubmed	Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains.	MYH1 MYH4	2.46e-06	2	55	2	11150240
Pubmed	Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice.	MYH1 MYH4	2.46e-06	2	55	2	11744674
Pubmed	Growth and muscle defects in mice lacking adult myosin heavy chain genes.	MYH1 MYH4	2.46e-06	2	55	2	9382868
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ZNF462 DYM ATP11B ARID5B HECTD4 ARHGEF38 KCNMA1 KDM2A RRBP1 MLPH LRCH3 PDZD2	2.88e-06	1489	55	12	28611215
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FOCAD TTYH1 PPP4R1 WAPL TXNDC15 COG1 APC2 ARID5B HECTD4 RRBP1 ANKRD6	4.51e-06	1285	55	11	35914814
Pubmed	Transition of myosin heavy chain isoforms in human laryngeal abductors following denervation.	MYH1 MYH4	7.36e-06	3	55	2	26059207
Pubmed	Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.	MYH1 MYH4	7.36e-06	3	55	2	36515178
Pubmed	Three linked myosin heavy chain genes clustered within 370 kb of each other show independent transcriptional and post-transcriptional regulation during differentiation of a mouse muscle cell line.	MYH1 MYH4	1.47e-05	4	55	2	1985022
Pubmed	Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.	MYH1 MYH4	1.47e-05	4	55	2	10388558
Pubmed	Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle.	MYH1 MYH4	1.47e-05	4	55	2	11029314
Pubmed	A human YAC transgene rescues craniofacial and neural tube development in PDGFRalpha knockout mice and uncovers a role for PDGFRalpha in prenatal lung growth.	MYH1 MYH4	1.47e-05	4	55	2	11023856
Pubmed	Modulation of skeletal muscle fiber type by mitogen-activated protein kinase signaling.	MYH1 MYH4	1.47e-05	4	55	2	18417546
Pubmed	Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation.	MYH1 MYH4	1.47e-05	4	55	2	12547197
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	WAPL ATP11B USP38 HECTD4 NUP188 RRBP1 CARNS1	1.95e-05	529	55	7	14621295
Pubmed	Characterization of long cDNA clones from human adult spleen.	KDM2A GRIP2 ATG16L2	1.97e-05	33	55	3	11214971
Pubmed	Detection of Gene and Protein Expression in Mouse Embryos and Tissue Sections.	MYH1 MYH4	2.45e-05	5	55	2	30737693
Pubmed	Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.	MYH1 MYH4	2.45e-05	5	55	2	3829126
Pubmed	Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.	MYH1 MYH4	2.45e-05	5	55	2	6196357
Pubmed	Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development.	MYH1 MYH4	2.45e-05	5	55	2	12919077
Pubmed	A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity.	MYH1 MYH4	3.67e-05	6	55	2	20417199
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH1 MYH4	3.67e-05	6	55	2	10077619
Pubmed	A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre.	MYH1 MYH4	3.67e-05	6	55	2	17559643
Pubmed	Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.	MYH1 MYH4	3.67e-05	6	55	2	1728586
Pubmed	Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.	MYH1 MYH4	3.67e-05	6	55	2	10588881
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH1 MYH4	5.13e-05	7	55	2	35210422
Pubmed	ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.	MYH1 MYH4	5.13e-05	7	55	2	29758057
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH1 MYH4	5.13e-05	7	55	2	16819597
Pubmed	Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.	MYH1 MYH4	6.83e-05	8	55	2	26993635
Pubmed	Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene.	MYH1 MYH4	6.83e-05	8	55	2	3864153
Pubmed	Long noncoding RNA lncMREF promotes myogenic differentiation and muscle regeneration by interacting with the Smarca5/p300 complex.	MYH1 MYH4	6.83e-05	8	55	2	36200826
Pubmed	Cell lineage- and expression-based inference of the roles of forkhead box transcription factor Foxc2 in craniofacial development.	MYH1 MYH4	6.83e-05	8	55	2	33667029
Pubmed	A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning.	MYH1 MYH4	6.83e-05	8	55	2	14667415
Pubmed	The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse.	MITF MLPH	8.78e-05	9	55	2	17247639
Pubmed	Discovery of tissue-specific exons using comprehensive human exon microarrays.	DYM ATP11B	8.78e-05	9	55	2	17456239
Pubmed	GASP-2 overexpressing mice exhibit a hypermuscular phenotype with contrasting molecular effects compared to GASP-1 transgenics.	MYH1 MYH4	8.78e-05	9	55	2	31960486
Pubmed	During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.	MYH1 MYH4	1.10e-04	10	55	2	19506036
Pubmed	Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.	MYH1 MYH4	1.34e-04	11	55	2	18310078
Pubmed	Extracellular matrix protein composition dynamically changes during murine forelimb development.	MYH1 MYH4	1.34e-04	11	55	2	38303699
Pubmed	The histone code reader Spin1 controls skeletal muscle development.	MYH1 MYH4	1.34e-04	11	55	2	29168801
Pubmed	Modulation of contractile protein gene expression in fetal murine crural muscles: emergence of muscle diversity.	MYH1 MYH4	1.34e-04	11	55	2	8136524
Pubmed	Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.	MYH1 MYH4	1.34e-04	11	55	2	16024798
Pubmed	TAF7L modulates brown adipose tissue formation.	MYH1 MYH4	1.89e-04	13	55	2	24876128
Pubmed	Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.	MYH1 MYH4	1.89e-04	13	55	2	8404542
Pubmed	Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy.	MYH1 MYH4	2.21e-04	14	55	2	24938781
Pubmed	Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice.	MYH1 MYH4	2.21e-04	14	55	2	27184118
Pubmed	Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation.	MYH1 MYH4	2.21e-04	14	55	2	33742095
Pubmed	Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.	MYH1 MYH4	2.54e-04	15	55	2	24852826
Pubmed	Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations.	MITF MLPH	2.54e-04	15	55	2	2379821
Pubmed	Iris phenotypes and pigment dispersion caused by genes influencing pigmentation.	MITF MLPH	2.54e-04	15	55	2	18715234
Pubmed	Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci.	MITF MLPH	2.54e-04	15	55	2	6696991
Pubmed	MusTRD can regulate postnatal fiber-specific expression.	MYH1 MYH4	2.90e-04	16	55	2	16494860
Pubmed	Linkage analyses using biochemical variants in mice. 3. Linkage relationships of eleven biochemical markers.	MITF MLPH	2.90e-04	16	55	2	5424503
Pubmed	A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.	MYH1 MYH4	2.90e-04	16	55	2	19922871
Pubmed	IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.	MYH1 MYH4	3.29e-04	17	55	2	22351927
Pubmed	Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis.	MYH1 MYH4	3.70e-04	18	55	2	25753484
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ZNF462 KDM2A GRIP2 RRBP1	4.49e-04	225	55	4	12168954
Pubmed	Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays.	MITF KCNMA1	4.58e-04	20	55	2	26341476
Pubmed	A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.	MYH1 MYH4	5.56e-04	22	55	2	24301466
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ATP11B KDM2A ANKRD6	5.75e-04	102	55	3	10231032
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	WAPL HECTD4 NUP188 RRBP1 LRCH3	6.55e-04	440	55	5	34244565
Pubmed	Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells.	NEDD9 TTYH1	7.79e-04	26	55	2	15890332
Pubmed	SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing.	MYH1 MYH4	7.79e-04	26	55	2	26586428
Pubmed	The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.	MRPL10 MRPL45	7.79e-04	26	55	2	11551941
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	FOCAD MYH1 MYH4 TM2D2 ARID5B NUP188	1.06e-03	736	55	6	29676528
Pubmed	Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism.	MYH1 MYH4	1.11e-03	31	55	2	30081710
Pubmed	Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.	MYH1 MYH4	1.11e-03	31	55	2	21985497
Pubmed	Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.	KCNMA1 KLHL32	1.18e-03	32	55	2	24954895
Pubmed	Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.	MYH1 MYH4	1.26e-03	33	55	2	32094117
Pubmed	Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.	CFI AGBL1	1.26e-03	33	55	2	24204828
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	WAPL RNH1 MRPL10 MRPL45 ECSIT	1.32e-03	515	55	5	31617661
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	WAPL ARID5B MRPL10 NUP188 ANKRD6 KLHL32 PARP12	1.54e-03	1084	55	7	11544199
Cytoband	11q13.2	KDM2A CARNS1	1.47e-03	47	55	2	11q13.2
GeneFamily	Myosin heavy chains	MYH1 MYH4	3.34e-04	15	33	2	1098
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	PPP4R1 NBEAL1 ARHGEF38 AGBL1 MLPH PDZD2	1.20e-07	188	55	6	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 ZNF462 MYH1 MYH4 GRM5	3.03e-06	182	55	5	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	MAL2 ARHGEF38 AGBL1 MLPH PDZD2	3.93e-06	192	55	5	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	critical-Lymphoid-NK\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ZNF462 MLIP MITF C10orf90 MLPH	4.03e-06	193	55	5	6be11fef87af04ee7a3cc223882ccd4077caded9
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MAL2 ARHGEF38 AGBL1 MLPH PDZD2	4.68e-06	199	55	5	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Mesenchymal-Mesoderm\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	HTR1D MLIP MLPH	1.53e-05	39	55	3	3479d255b87fa8042c51d80a3eb81a774850132e
ToppCell	TCGA-Uvea\|World / Sample_Type by Project: Shred V9	MLIP RTTN MITF C10orf90	2.78e-05	141	55	4	015451a83087f2705d3315ebc8f23797c6f10ed6
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage\|356C / Donor, Lineage, Cell class and subclass (all cells)	MITF KCNMA1 CARNS1 ZMYND12	4.79e-05	162	55	4	2f19539c455d1e5d514725845234c7547020e6ad
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	ZNF462 HECTD4 ARHGEF38 CFI	4.79e-05	162	55	4	2259e9536147e9cdee772e3a30ba7d104573262c
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ZNF462 HECTD4 ARHGEF38 CFI	5.26e-05	166	55	4	89e2b8453180983533faccb4275867861876d7ee
ToppCell	Control\|World / group, cell type (main and fine annotations)	NEDD9 AGBL1 MLPH PDZD2	5.51e-05	168	55	4	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MYH1 MYH4 ARHGEF38	6.21e-05	62	55	3	a20620a8869721ea62984c2022ee1b484b455824
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MYH1 MYH4 ARHGEF38	6.21e-05	62	55	3	ee694c06bcd924b4ddf744178ba3a99e04eed51b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 ZNF462 MYH1 MYH4	6.46e-05	175	55	4	284fdc7a9d303636a637041846850d19d114861a
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYH1 MLIP HHIPL2 KCNMA1	6.46e-05	175	55	4	f1394aacc8a94ca555dd19aaed5a18da99c6bf40
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYH1 MLIP HHIPL2 KCNMA1	6.46e-05	175	55	4	7bf1194d93fbe2dbf9d953e0a32b2a6d88251ed1
ToppCell	wk_15-18-Mesenchymal-Mesothelial-intermediate_mesothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFI CARNS1 MLPH PDZD2	7.05e-05	179	55	4	b1f085e4c8d65d5cdbfaf2db80343638abb08979
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet-BEST2+_Goblet_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAL2 HHIPL2 KCNMA1 MLPH	7.05e-05	179	55	4	c833ded1f9e87be2ba2037820d92a389560b711c
ToppCell	P28-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TTYH1 MLIP CARNS1 MLPH	7.21e-05	180	55	4	1e819c5c87704ec6535dfeaae56561895e239d07
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD9 MYH1 MYH4 GRM5	7.36e-05	181	55	4	6956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	ARHGEF38 AGBL1 MLPH PDZD2	7.85e-05	184	55	4	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGEF38 ANKRD6 AGBL1 MLPH	7.85e-05	184	55	4	102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTYH1 MLIP CARNS1 KLHL32	7.85e-05	184	55	4	9f8cd5ab5af6c35a1be25d70a125b9a3f4dd667a
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAL2 ARHGEF38 ANKRD6 AGBL1	8.01e-05	185	55	4	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	MLIP MITF GRIP2 PDZD2	8.01e-05	185	55	4	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MAL2 ARHGEF38 AGBL1 MLPH	8.18e-05	186	55	4	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	21-Trachea-Epithelial-Goblet-like_secretory\|Trachea / Age, Tissue, Lineage and Cell class	MAL2 RRBP1 CFI MLPH	8.18e-05	186	55	4	f8cddad28896f0edf10a8645fa49a011b22b120d
ToppCell	E12.5-Epithelial-epithelial_progenitor_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NEDD9 TTYH1 MAL2 CFI	8.35e-05	187	55	4	ab6f4d387218b4651fdadbf269806c1ddc96a1d2
ToppCell	droplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH1 KCNMA1 GRIP2 CARNS1	8.35e-05	187	55	4	2591fe1552cd10925ad1d8d1f062a057ce6bdad9
ToppCell	droplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH1 KCNMA1 GRIP2 CARNS1	8.35e-05	187	55	4	59313a47a6012b2413d7d3673bb05fb7e49fd88f
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARHGEF38 AGBL1 MLPH PDZD2	8.35e-05	187	55	4	5df9e1f5ca32217af255e76e6fb5afa346337811
ToppCell	343B-Lymphocytic-ILC-ILC-1\|343B / Donor, Lineage, Cell class and subclass (all cells)	DYM ATP11B ATG16L2 PARP12	8.52e-05	188	55	4	8f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ZNF462 RTTN MITF KCNMA1	8.52e-05	188	55	4	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	MAL2 ARHGEF38 MLPH PDZD2	8.52e-05	188	55	4	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	MLIP MITF GRIP2 PDZD2	8.70e-05	189	55	4	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	MLIP MITF GRIP2 PDZD2	8.88e-05	190	55	4	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	BL-critical-LOC-Epithelial-Secretory\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MAL2 CFI MLPH PDZD2	8.88e-05	190	55	4	f2abe4bc28e934287e2dcd7b9399d5af78c5c8cf
ToppCell	COVID-19-lung-AT2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MAL2 ARHGEF38 AGBL1 MLPH	8.88e-05	190	55	4	27a1a86620fe9b5ee930d388b32352206485e6d0
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	MLIP MITF GRIP2 PDZD2	8.88e-05	190	55	4	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	MLIP MITF GRIP2 PDZD2	9.06e-05	191	55	4	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MAL2 AGBL1 MLPH PDZD2	9.06e-05	191	55	4	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAL2 ARHGEF38 MLPH PDZD2	9.06e-05	191	55	4	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGEF38 AGBL1 MLPH PDZD2	9.06e-05	191	55	4	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	MAL2 ARHGEF38 AGBL1 MLPH	9.06e-05	191	55	4	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	18-Distal-Epithelial-Secretory_progenitor\|Distal / Age, Tissue, Lineage and Cell class	MAL2 ARHGEF38 CFI MLPH	9.25e-05	192	55	4	9fae988ecd2ef1231bfd42a678a4903517694cbe
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	ARHGEF38 AGBL1 MLPH PDZD2	9.25e-05	192	55	4	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARHGEF38 C10orf90 AGBL1 PDZD2	9.25e-05	192	55	4	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	ARHGEF38 AGBL1 MLPH PDZD2	9.25e-05	192	55	4	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2\|Adult / Lineage, Cell type, age group and donor	ARHGEF38 AGBL1 MLPH PDZD2	9.43e-05	193	55	4	738f4f0a9ddde2432b429ab46838e353b1790589
ToppCell	11.5-Airway-Epithelial-Bud_tip_progenitor\|Airway / Age, Tissue, Lineage and Cell class	TTYH1 MAL2 C10orf90 CFI	9.43e-05	193	55	4	f0a07bb221a497a9f7cc706045d5205269be4515
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGEF38 AGBL1 MLPH PDZD2	9.62e-05	194	55	4	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	18-Airway-Epithelial-Secretory_progenitor\|Airway / Age, Tissue, Lineage and Cell class	MAL2 ARHGEF38 CFI MLPH	9.62e-05	194	55	4	9a2efa50731135a178141aae55fa8b3e022c9904
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MAL2 ARHGEF38 MLPH PDZD2	9.62e-05	194	55	4	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MAL2 ARHGEF38 MLPH PDZD2	9.82e-05	195	55	4	9406866f99555198a9be311fbd65751b70f35446
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH4 WAPL KCNMA1 RRBP1	9.82e-05	195	55	4	5c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RNH1 C10orf90 CARNS1 KLHL32	1.00e-04	196	55	4	37a5f9f3988778655580bd0383811bb4930c1551
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF38 AGBL1 MLPH PDZD2	1.06e-04	199	55	4	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF38 AGBL1 MLPH PDZD2	1.06e-04	199	55	4	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	Biopsy_Other_PF-Epithelial-AT2\|Biopsy_Other_PF / Sample group, Lineage and Cell type	MAL2 ARHGEF38 MLPH PDZD2	1.06e-04	199	55	4	9a65acfe9bf500db72142469cf17bf0973540001
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZNF462 C10orf90 GRM5 PDZD2	1.06e-04	199	55	4	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF38 AGBL1 MLPH PDZD2	1.06e-04	199	55	4	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TTYH1 C10orf90 CARNS1 KLHL32	1.06e-04	199	55	4	6fb5f931e6217142de38c1fffc011e63bda4772b
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGEF38 CFI MLPH PDZD2	1.06e-04	199	55	4	2dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TTYH1 C10orf90 CARNS1 KLHL32	1.06e-04	199	55	4	5d2e85e40b6b52b1809e680b952913d77215b3d0
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TTYH1 C10orf90 CARNS1 KLHL32	1.06e-04	199	55	4	1bb5797e8e0552bf9b44bf4c958d1aa6dbe6c756
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TTYH1 C10orf90 CARNS1 KLHL32	1.06e-04	199	55	4	9dd4b17fb8c70ab9e126b23b72600463f3db832d
ToppCell	Bronchial-10x5prime-Epithelial-Epi_alveolar-AT2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MAL2 ARHGEF38 AGBL1 MLPH	1.08e-04	200	55	4	b535323e18d9fb0dde1e0026df142c831e48c29f
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF38 KCNMA1 RRBP1 MLPH	1.08e-04	200	55	4	0eb9ad8c0373bcc62029ec21c590ed03aaacd039
Disease	lean body mass	ZNF462 PPP4R1 APC2 KCNMA1 KDM2A ANKRD6	5.95e-05	379	53	6	EFO_0004995
Disease	generalized anxiety disorder (implicated_via_orthology)	ZNF462 HTR1D	8.80e-05	8	53	2	DOID:14320 (implicated_via_orthology)
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH1 MYH4	1.41e-04	10	53	2	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH1 MYH4	1.41e-04	10	53	2	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH1 MYH4	1.41e-04	10	53	2	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH1 MYH4	1.41e-04	10	53	2	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH1 MYH4	1.41e-04	10	53	2	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH1 MYH4	1.41e-04	10	53	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH1 MYH4	1.41e-04	10	53	2	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH1 MYH4	1.41e-04	10	53	2	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH1 MYH4	2.07e-04	12	53	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH1 MYH4	2.07e-04	12	53	2	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH1 MYH4	2.44e-04	13	53	2	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH1 MYH4	3.27e-04	15	53	2	DOID:0050646 (implicated_via_orthology)
Disease	myocardial infarction	NBEAL1 MITF HECTD4 PARP12 PDZD2	4.11e-04	350	53	5	EFO_0000612
Disease	Meckel syndrome type 1	TXNDC15 TCTN2	4.75e-04	18	53	2	C3714506
Disease	diet measurement, fasting blood insulin measurement	CFI AGBL1	7.15e-04	22	53	2	EFO_0004466, EFO_0008111
Disease	diet measurement, HOMA-IR	CFI AGBL1	7.82e-04	23	53	2	EFO_0004501, EFO_0008111
Disease	response to angiotensin-converting enzyme inhibitor, response to angiotensin receptor blocker, angioedema	KCNMA1 KDM2A	1.00e-03	26	53	2	EFO_0005325, EFO_0005532, EFO_0010735
Disease	forced expiratory volume, response to bronchodilator	WAPL SOHLH2 ARID5B ARHGEF38 KLHL32	1.21e-03	445	53	5	EFO_0004314, GO_0097366
Disease	Intellectual Disability	ZNF462 MTF1 TMEM94 APC2 RTTN	1.23e-03	447	53	5	C3714756
Disease	coronary artery disease	NEDD9 NBEAL1 MITF HECTD4 RRBP1 ANKRD6 ATG16L2 PARP12	1.23e-03	1194	53	8	EFO_0001645
Disease	Age related macular degeneration	CFI PARP12	1.33e-03	30	53	2	C0242383
Disease	Global developmental delay	ZNF462 TMEM94 APC2	1.78e-03	133	53	3	C0557874

Protein segments in the cluster

Peptide	Gene	Start	Entry
QLSSALLHANHTLST	TTYH1	121	Q9H313
LSDLSINSTECLHVH	CFI	171	P05156
TSLSLSHDQLHLLSC	ATG16L2	506	Q8NAA4
SHDQLHLLSCSRDNT	ATG16L2	511	Q8NAA4
HQILSQTSHDLNECS	NEDD9	496	Q14511
LSNALNSCHDFASHL	ARHGEF38	401	Q9NXL2
CLVSQHLQALSSTAS	CARNS1	741	A5YM72
SASCSHQLLAQAATL	AGBL1	1046	Q96MI9
HLACQNSHSQSTRVL	ANKRD6	146	Q9Y2G4
ENSHTLLSHNACNKL	MLIP	426	Q5VWP3
TLDLHSSLHQTCAEN	NBEAL1	496	Q6ZS30
LLSLSASHNQLSHTD	LRCH3	451	Q96II8
CNSSLTLKTHHVQDS	GRM5	381	P41594
SSNIHANHLSLDASS	KCNMA1	26	Q12791
CELASALSHLDASHL	PDZD2	1196	O15018
NNHLLALDHSNSDLS	DDIAS	201	Q8IXT1
SALAHALQSSRHDCD	MYH1	1331	P12882
SSILLAQSLQHCIHS	HECTD4	2501	Q9Y4D8
NCRNSHSLTTEHNLS	PARP12	111	Q9H0J9
CLQTLLQHLTSHSLT	APC2	626	O95996
LSRLDLSHCSHLTDQ	KDM2A	1066	Q9Y2K7
LSHCSHLTDQSSNLL	KDM2A	1071	Q9Y2K7
CHLHSLLQLDSSSSR	COG1	151	Q8WTW3
LEIINSCLTNSLHHN	DYM	536	Q7RTS9
SSLCSLNSSLHEGHS	HTR1D	251	P28221
AAATSLHDLHCNTTI	MAL2	121	Q969L2
EATSCSLHRSAHNAT	IL21R	61	Q9HBE5
HSNCHSAISLLTNDR	HHIPL2	141	Q6UWX4
SHATALATLRQCSHE	GRIP2	211	Q9C0E4
LHCSAAAHSSEQSLV	ECSIT	41	Q9BQ95
HLHLSTLSSSQSRAS	FOCAD	1336	Q5VW36
ELLSDTAHLNETHCA	MLPH	51	Q9BV36
LSSLLDLHASQTCSL	MROH2A	1021	A6NES4
HVLSSNESSLRSSNH	RTTN	186	Q86VV8
LLCTLSSESHQEAAS	PPP4R1	406	Q8TF05
CLNNSDHDRLHTLVT	MRPL45	151	Q9BRJ2
DTNHSLCLSDLSLLS	MTF1	331	Q14872
STLAHALQSARHDCD	MYH4	1331	Q9Y623
DDLCSSLSQTHHGQS	ARID5B	726	Q14865
HRSVLSLNLNCSSHR	C10orf90	286	Q96M02
LSHLNNLSHLTTSSS	ATP11B	456	Q9Y2G3
LLHCVSRSHSQNATA	TM2D2	26	Q9BX73
LCHTQSSHASLRADA	RRBP1	891	Q9P2E9
LQHHADLTCTTTLDL	MITF	436	O75030
LTCLTAQTHSLLQHQ	MRPL10	211	Q7Z7H8
SDHLCNIALQESHSA	TMEM94	606	Q12767
HFLALDASQHSSLST	TXNDC15	241	Q96J42
SHDILQHQDSNCSAT	TXLNGY	21	Q9BZA5
TLDDSQHHQNLSLCT	WAPL	706	Q7Z5K2
HAILNLCHETDLHSS	NUP188	741	Q5SRE5
SCSSLAATLLANHSL	RNH1	386	P13489
HQSEALALASSQSHL	USP38	876	Q8NB14
LKSTDCSNATHSLLH	ZMYND12	161	Q9H0C1
HCDSKLQSTAELTSH	ZNF462	1896	Q96JM2
HISSAALSLNSLHTV	SOHLH2	351	Q9NX45
SASHNSSCSAHLLIQ	TCTN2	126	Q96GX1
QRLCHSESHNDSVLA	KLHL32	16	Q96NJ5