Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2	1.09e-04	4	86	2	GO:0005219
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR2	2.72e-04	6	86	2	GO:0048763
MousePheno	abnormal orientation of outer hair cell stereociliary bundles	CELSR1 MYO7A CDH23 LRP6	6.01e-06	24	71	4	MP:0004491
MousePheno	abnormal orientation of cochlear hair cell stereociliary bundles	CELSR1 MYO7A CDH23 LRP6	2.84e-05	35	71	4	MP:0004522
Domain	Ryanrecept_TM4-6	RYR1 RYR2	5.98e-05	3	84	2	IPR009460
Domain	RyR	RYR1 RYR2	5.98e-05	3	84	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR2	5.98e-05	3	84	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR2	5.98e-05	3	84	2	PF06459
Domain	Ryan_recept	RYR1 RYR2	5.98e-05	3	84	2	IPR013333
Domain	CA	FREM2 CELSR1 CELSR3 CDH23 CDHR5	1.70e-04	115	84	5	SM00112
Domain	Cadherin	FREM2 CELSR1 CELSR3 CDH23 CDHR5	1.92e-04	118	84	5	IPR002126
Domain	RIH_assoc	RYR1 RYR2	2.96e-04	6	84	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR2	2.96e-04	6	84	2	IPR013662
Domain	RIH_dom	RYR1 RYR2	2.96e-04	6	84	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR2	2.96e-04	6	84	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2	2.96e-04	6	84	2	IPR015925
Domain	-	RYR1 RYR2	2.96e-04	6	84	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR2	2.96e-04	6	84	2	PF01365
Domain	Ins145_P3_rec	RYR1 RYR2	2.96e-04	6	84	2	PF08709
Domain	ConA-like_dom	CELSR1 CELSR3 NBEAL2 MDGA1 RYR1 RYR2	4.61e-04	219	84	6	IPR013320
Domain	DHC_N1	DYNC2H1 DYNC1H1	5.50e-04	8	84	2	PF08385
Domain	Dynein_heavy_dom-1	DYNC2H1 DYNC1H1	5.50e-04	8	84	2	IPR013594
Domain	SOCS_box	NEURL2 ASB16 SOCS1	6.61e-04	38	84	3	PF07525
Domain	SOCS_box	NEURL2 ASB16 SOCS1	7.14e-04	39	84	3	SM00969
Domain	SOCS	NEURL2 ASB16 SOCS1	7.14e-04	39	84	3	PS50225
Domain	SOCS_box	NEURL2 ASB16 SOCS1	7.14e-04	39	84	3	IPR001496
Domain	MIR	RYR1 RYR2	8.79e-04	10	84	2	PS50919
Domain	MIR	RYR1 RYR2	8.79e-04	10	84	2	PF02815
Domain	MIR	RYR1 RYR2	8.79e-04	10	84	2	SM00472
Domain	MIR_motif	RYR1 RYR2	8.79e-04	10	84	2	IPR016093
Domain	GAIN_dom_N	CELSR1 CELSR3	1.07e-03	11	84	2	IPR032471
Domain	GAIN	CELSR1 CELSR3	1.07e-03	11	84	2	PF16489
Domain	ARM-like	NBEAL2 AP5Z1 EFR3B UTP20 ATAD2 EFR3A	1.37e-03	270	84	6	IPR011989
Domain	Cadherin_CS	CELSR1 CELSR3 CDH23 CDHR5	1.48e-03	109	84	4	IPR020894
Domain	CADHERIN_1	CELSR1 CELSR3 CDH23 CDHR5	1.69e-03	113	84	4	PS00232
Domain	CADHERIN_2	CELSR1 CELSR3 CDH23 CDHR5	1.74e-03	114	84	4	PS50268
Domain	-	CELSR1 CELSR3 CDH23 CDHR5	1.74e-03	114	84	4	2.60.40.60
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DYNC1H1	1.76e-03	14	84	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DYNC1H1	1.76e-03	14	84	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DYNC1H1	1.76e-03	14	84	2	IPR013602
Domain	DHC_N2	DYNC2H1 DYNC1H1	1.76e-03	14	84	2	PF08393
Domain	MT	DYNC2H1 DYNC1H1	1.76e-03	14	84	2	PF12777
Domain	AAA_8	DYNC2H1 DYNC1H1	1.76e-03	14	84	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 DYNC1H1	1.76e-03	14	84	2	IPR011704
Domain	AAA_5	DYNC2H1 DYNC1H1	1.76e-03	14	84	2	PF07728
Domain	Cadherin-like	CELSR1 CELSR3 CDH23 CDHR5	1.86e-03	116	84	4	IPR015919
Domain	DHC_fam	DYNC2H1 DYNC1H1	2.02e-03	15	84	2	IPR026983
Domain	Dynein_heavy_dom	DYNC2H1 DYNC1H1	2.02e-03	15	84	2	IPR004273
Domain	Dynein_heavy	DYNC2H1 DYNC1H1	2.02e-03	15	84	2	PF03028
Domain	-	AP5Z1 EFR3B UTP20 ATAD2 EFR3A	3.27e-03	222	84	5	1.25.10.10
Domain	ARM-type_fold	ZBTB7C UPF2 NBEAL2 EFR3B UTP20 EFR3A	4.24e-03	339	84	6	IPR016024
Domain	HormR	CELSR1 CELSR3	5.61e-03	25	84	2	SM00008
Domain	-	KLHL2 KLHL21	6.52e-03	27	84	2	2.130.10.80
Domain	HRM	CELSR1 CELSR3	7.00e-03	28	84	2	PF02793
Domain	EGF_LAM_2	CELSR1 CELSR3	8.01e-03	30	84	2	PS50027
Domain	EGF_LAM_1	CELSR1 CELSR3	8.01e-03	30	84	2	PS01248
Domain	BTB	KCTD12 KLHL2 ZBTB7C KLHL21	8.85e-03	180	84	4	SM00225
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KCTD12 FAM20C CELSR1 PLOD3 CELSR3 MYO7A PTPRS VPS39 PLEKHO2 KLHL21 NBEAL2 NLRX1 USP40 GTF2IRD1 STK11IP PRAG1 TTC38 DYNC1H1 RYR1 ARAP1 SMG6	3.00e-13	1105	87	21	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CELSR3 GTF3C2 VPS39 KLHL21 NBEAL2 AP5Z1 EFR3B ANKIB1 DICER1 ARAP1 SMG6 EFR3A	8.54e-09	529	87	12	14621295
Pubmed	Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.	CELSR1 CELSR3 MDGA1 SSPOP	4.88e-08	15	87	4	20473291
Pubmed	Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.	FREM2 CELSR1 CELSR3 PTPRS DYNC1H1	7.45e-07	67	87	5	21875946
Pubmed	A non-autonomous function of the core PCP protein VANGL2 directs peripheral axon turning in the developing cochlea.	CELSR1 CELSR3 MYO7A	5.39e-06	14	87	3	29784671
Pubmed	Mutation analysis of the MYO7A and CDH23 genes in Japanese patients with Usher syndrome type 1.	MYO7A CDH23	6.19e-06	2	87	2	20844544
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	6.19e-06	2	87	2	17259277
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	6.19e-06	2	87	2	14722100
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	6.19e-06	2	87	2	26009179
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	6.19e-06	2	87	2	32899693
Pubmed	Progressive hearing loss and increased susceptibility to noise-induced hearing loss in mice carrying a Cdh23 but not a Myo7a mutation.	MYO7A CDH23	6.19e-06	2	87	2	14648237
Pubmed	Inhibition of microtubules and dynein rescues human immunodeficiency virus type 1 from owl monkey TRIMCyp-mediated restriction in a cellular context-specific fashion.	DYNC2H1 DYNC1H1	6.19e-06	2	87	2	25502651
Pubmed	[Usher type I syndrome in children: genotype/phenotype correlation and cochlear implant benefits].	MYO7A CDH23	6.19e-06	2	87	2	18323324
Pubmed	Genetic analysis of the cytoplasmic dynein subunit families.	DYNC2H1 DYNC1H1	6.19e-06	2	87	2	16440056
Pubmed	Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration.	MYO7A CDH23	6.19e-06	2	87	2	14609561
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	6.19e-06	2	87	2	30542613
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	6.19e-06	2	87	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	6.19e-06	2	87	2	11673493
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	6.19e-06	2	87	2	11673462
Pubmed	Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant mice.	MYO7A CDH23	6.19e-06	2	87	2	12121736
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	6.19e-06	2	87	2	25370123
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	6.19e-06	2	87	2	15033925
Pubmed	Activation of OX40 augments Th17 cytokine expression and antigen-specific uveitis.	CAMP TNFRSF4	6.19e-06	2	87	2	20952591
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	6.19e-06	2	87	2	18618700
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2	1.85e-05	3	87	2	18403125
Pubmed	EFR3s are palmitoylated plasma membrane proteins that control responsiveness to G-protein-coupled receptors.	EFR3B EFR3A	1.85e-05	3	87	2	25380825
Pubmed	Genetic analysis through OtoSeq of Pakistani families segregating prelingual hearing loss.	MYO7A CDH23	1.85e-05	3	87	2	23770805
Pubmed	Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice.	MYO7A CDH23	1.85e-05	3	87	2	17050716
Pubmed	Recombinant human cytoplasmic dynein heavy chain 1 and 2: observation of dynein-2 motor activity in vitro.	DYNC2H1 DYNC1H1	1.85e-05	3	87	2	21723285
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR2	1.85e-05	3	87	2	18434746
Pubmed	Survey of the frequency of USH1 gene mutations in a cohort of Usher patients shows the importance of cadherin 23 and protocadherin 15 genes and establishes a detection rate of above 90%.	MYO7A CDH23	1.85e-05	3	87	2	16679490
Pubmed	UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2.	UPF2 SMG6	1.85e-05	3	87	2	38709891
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR2	1.85e-05	3	87	2	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR2	1.85e-05	3	87	2	7876312
Pubmed	Differential distribution of harmonin isoforms and their possible role in Usher-1 protein complexes in mammalian photoreceptor cells.	MYO7A CDH23	1.85e-05	3	87	2	14578428
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR2	1.85e-05	3	87	2	21881589
Pubmed	Cytoplasmic dynein promotes HIV-1 uncoating.	DYNC2H1 DYNC1H1	1.85e-05	3	87	2	25375884
Pubmed	Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.	RYR1 RYR2	1.85e-05	3	87	2	24123915
Pubmed	Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids.	MYO7A CDH23	1.85e-05	3	87	2	20639393
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR2	1.85e-05	3	87	2	12213830
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	RYR1 RYR2	1.85e-05	3	87	2	23278119
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR2	1.85e-05	3	87	2	9242641
Pubmed	Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.	DYNC2H1 DYNC1H1	1.85e-05	3	87	2	8666668
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR2	1.85e-05	3	87	2	22948152
Pubmed	Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.	RYR1 RYR2	1.85e-05	3	87	2	23454728
Pubmed	The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development.	CELSR1 CELSR3	1.85e-05	3	87	2	11677057
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR2	1.85e-05	3	87	2	10788707
Pubmed	The anatomy and development of the mutants pirouette, shaker-1 and waltzer in the mouse.	MYO7A CDH23	1.85e-05	3	87	2	13336002
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR2	1.85e-05	3	87	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR2	1.85e-05	3	87	2	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR2	1.85e-05	3	87	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR2	1.85e-05	3	87	2	11159936
Pubmed	Pathogenic variants of DYNC2H1, KIAA0556, and PTPN11 associated with hypothalamic hamartoma.	DYNC2H1 KATNIP	1.85e-05	3	87	2	31197031
Pubmed	Intracellular calcium release channel expression during embryogenesis.	RYR1 RYR2	1.85e-05	3	87	2	9986730
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR2	1.85e-05	3	87	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR2	1.85e-05	3	87	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR2	1.85e-05	3	87	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR2	1.85e-05	3	87	2	7635066
Pubmed	Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells.	MYO7A CDH23	3.70e-05	4	87	2	16481439
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR2	3.70e-05	4	87	2	18206662
Pubmed	Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons.	RYR1 RYR2	3.70e-05	4	87	2	22504960
Pubmed	Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.	RYR1 RYR2	3.70e-05	4	87	2	23992453
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR2	3.70e-05	4	87	2	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR2	3.70e-05	4	87	2	9384575
Pubmed	The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.	CELSR1 CELSR3	3.70e-05	4	87	2	37224017
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR2	3.70e-05	4	87	2	9607712
Pubmed	S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.	RYR1 RYR2	3.70e-05	4	87	2	27226555
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR1 RYR2	3.70e-05	4	87	2	19120137
Pubmed	Developmental expression profiles of Celsr (Flamingo) genes in the mouse.	CELSR1 CELSR3	3.70e-05	4	87	2	11850187
Pubmed	FKBP binding characteristics of cardiac microsomes from diverse vertebrates.	RYR1 RYR2	3.70e-05	4	87	2	11237759
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR2	3.70e-05	4	87	2	23482488
Pubmed	Critical synergy of CD30 and OX40 signals in CD4 T cell homeostasis and Th1 immunity to Salmonella.	IGHM TNFRSF4	3.70e-05	4	87	2	18292503
Pubmed	Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.	CELSR1 CELSR3 LRP6	3.77e-05	26	87	3	37228654
Pubmed	Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin.	MYO7A CDH23	6.16e-05	5	87	2	12588794
Pubmed	Interactions in the network of Usher syndrome type 1 proteins.	MYO7A CDH23	6.16e-05	5	87	2	15590703
Pubmed	The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane.	EFR3B EFR3A	6.16e-05	5	87	2	26571211
Pubmed	Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape.	MYO7A CDH23	6.16e-05	5	87	2	20332152
Pubmed	Characterization of Usher syndrome type I gene mutations in an Usher syndrome patient population.	MYO7A CDH23	6.16e-05	5	87	2	15660226
Pubmed	Usher I syndrome: unravelling the mechanisms that underlie the cohesion of the growing hair bundle in inner ear sensory cells.	MYO7A CDH23	6.16e-05	5	87	2	16219682
Pubmed	Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.	RYR1 RYR2	6.16e-05	5	87	2	22939628
Pubmed	Intracellular calcium-release channels: regulators of cell life and death.	RYR1 RYR2	6.16e-05	5	87	2	9124414
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR2	6.16e-05	5	87	2	23918386
Pubmed	Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes.	MYO7A CDH23	6.16e-05	5	87	2	22381527
Pubmed	Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation.	IGHM TNFRSF4	6.16e-05	5	87	2	21856952
Pubmed	CD4+ T cell help has an epitope-dependent impact on CD8+ T cell memory inflation during murine cytomegalovirus infection.	IGHM TNFRSF4	6.16e-05	5	87	2	19692644
Pubmed	The circulating microRNome demonstrates distinct lymphocyte subset-dependent signatures.	IGHM DICER1	6.16e-05	5	87	2	26639063
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR2	6.16e-05	5	87	2	19011160
Pubmed	Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle.	MYO7A CDH23	6.16e-05	5	87	2	12485990
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR2	9.22e-05	6	87	2	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR2	9.22e-05	6	87	2	26025922
Pubmed	Impact of the Usher syndrome on olfaction.	MYO7A CDH23	9.22e-05	6	87	2	26620972
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR2	9.22e-05	6	87	2	23463619
Pubmed	T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation.	IGHM TNFRSF4	9.22e-05	6	87	2	12538659
Pubmed	Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.	UPF2 SMG6	9.22e-05	6	87	2	25770585
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR2	9.22e-05	6	87	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR2	9.22e-05	6	87	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR2	9.22e-05	6	87	2	25966694
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR2	9.22e-05	6	87	2	19009018
Pubmed	Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.	UPF2 SMG6	9.22e-05	6	87	2	12554878
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR2	9.22e-05	6	87	2	16844763
Interaction	TOP3B interactions	KCTD12 FAM20C CELSR1 PLOD3 CELSR3 UPF2 MYO7A PTPRS VPS39 PLEKHO2 KLHL21 NBEAL2 NLRX1 USP40 GTF2IRD1 STK11IP PRAG1 TTC38 DYNC1H1 RYR1 ARAP1 SMG6	1.20e-07	1470	85	22	int:TOP3B
Interaction	DKKL1 interactions	FREM2 CELSR1 KIDINS220 CELSR3 LRP6 GTF2IRD1	7.48e-06	111	85	6	int:DKKL1
Interaction	PCDHGB1 interactions	FREM2 CELSR1 CELSR3 PTPRS NLRX1	1.84e-05	77	85	5	int:PCDHGB1
Interaction	TNNI2 interactions	UPF2 KLHL21 EFCAB2 RYR1	2.40e-05	40	85	4	int:TNNI2
Interaction	RYK interactions	FREM2 CELSR1 KIDINS220 SELENBP1 CELSR3 PTPRS DYNC1H1	3.18e-05	212	85	7	int:RYK
Interaction	CTSG interactions	FREM2 CELSR1 ELOA2 CAMP LRP6	5.10e-05	95	85	5	int:CTSG
Interaction	DCANP1 interactions	FREM2 CELSR1 CELSR3	6.68e-05	19	85	3	int:DCANP1
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR3	2.07e-05	3	48	2	913
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2	2.07e-05	3	48	2	287
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR3	2.07e-05	3	48	2	1189
GeneFamily	Ankyrin repeat domain containing	KIDINS220 ASB16 TRPC4 ANKIB1 ARAP1	4.41e-04	242	48	5	403
GeneFamily	Dyneins, cytoplasmic	DYNC2H1 DYNC1H1	5.28e-04	13	48	2	538
GeneFamily	Cadherin related	CDH23 CDHR5	9.15e-04	17	48	2	24
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL2 ZBTB7C KLHL21	5.40e-03	134	48	3	861
GeneFamily	Kelch like\|BTB domain containing	KLHL2 KLHL21	5.55e-03	42	48	2	617
GeneFamily	Ubiquitin specific peptidases	USP2 USP40	9.70e-03	56	48	2	366
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Astrocyte\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	USP2 FREM2 ZNF219 PLEKHO2 KLHL21 EFCAB2 CDH23	1.34e-07	200	87	7	b9bd6c4381c92bfc1bfff9aa778a62a41d08f1ef
ToppCell	facs-GAT-Fat-3m\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCTD12 PLOD3 KIDINS220 PTPRS LRP6 ARAP1	1.99e-06	190	87	6	1d92be1b41cff59e834a9d28868f554bd1f3e471
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	USP2 FREM2 EFCAB2 CDH23 ME1 RYR1	2.68e-06	200	87	6	be1abe5bb1ce4e7dfec63af4ed0fc5b96bf77866
ToppCell	CV-Healthy-3\|Healthy / Virus stimulation, Condition and Cluster	RCCD1 PLEKHO2 KLHL21 CDH23 SOCS1	1.30e-05	154	87	5	26bf81a86700db7e65c2384ffe94ed4253ea4047
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-neuroepithelial-like_cells\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	FAM156A KLHL2 PLOD3 RCCD1 SHISA7	1.92e-05	167	87	5	e488d9c7cf4355959e3833de3bd496c13fc11b1b
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RCCD1 NBEAL2 SSPOP NCCRP1 RYR1	2.03e-05	169	87	5	46f0f0de9a0894c454f93032e7a7a800f47c8276
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RCCD1 NBEAL2 SSPOP NCCRP1 RYR1	2.03e-05	169	87	5	9c9bb1b32fc6e22359424a262178906c3954415d
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	USP2 ZDHHC11B CELSR1 KLHL21 ADAMTS15	2.15e-05	171	87	5	1854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCTD12 PLOD3 AJM1 CAMP TNFRSF4	2.47e-05	176	87	5	8e89471f838ea81235256cc2470f1c12c9b75f8a
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D175\|Adult / Lineage, Cell type, age group and donor	FAM20C NEURL2 MYO7A ME1 RYR1	3.13e-05	185	87	5	ab5704b96f1d368911308797d10c7c52766ab134
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC6A1 ZBTB7C KCNT2 PZP RYR2	3.65e-05	191	87	5	08042952431ca1a6fd7dfc13f36eb28643979598
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC6A1 ZBTB7C KCNT2 PZP RYR2	3.65e-05	191	87	5	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	Tracheal-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC6A1 USP2 INAFM1 ADAMTS15 LRRC61	4.22e-05	197	87	5	06e17c9ad53463eee1007280b3f3e8b0cf446cdc
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	ZNF219 MYO7A DYNC2H1 PZP RYR2	4.33e-05	198	87	5	0c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCell	Transverse-Macrophage-LYVE1_Macrophage\|Transverse / Region, Cell class and subclass	FAM156A KCTD12 FAM20C MYO7A ME1	4.43e-05	199	87	5	facf79c256db5ae57bdb613e86ec90616a6f67ca
ToppCell	Transverse-(6)_Macrophage-(61)_LYVE1_Macrophage\|Transverse / shred on region, Cell_type, and subtype	FAM156A KCTD12 FAM20C MYO7A ME1	4.43e-05	199	87	5	dcc2a7f4d1fa30aaaad655dd59c5a2b039d264bf
ToppCell	Transverse-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	FAM156A NEURL2 GTF3C2 NBEAL2 ME1	4.43e-05	199	87	5	fd75dccb37d96448edf72b7d042b06833d4ead24
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SLC6A1 ZBTB7C KCNT2 PZP RYR2	4.54e-05	200	87	5	9169a9ec8e9ab95d90a64c5a19ac666a5cf82313
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2\|Control_saline / Treatment groups by lineage, cell group, cell type	KCNT2 LRP6 PZP MDGA1 RYR2	4.54e-05	200	87	5	bc8949eb34482aca166c4602ff6ab876cb4c2c3c
Drug	Clemizole hydrochloride [1163-36-6]; Down 200; 11uM; MCF7; HT_HG-U133A	NR2C1 PTPRS PLEKHO2 LRP6 TTC38 RYR2 ARAP1	9.84e-06	197	86	7	2301_DN
Drug	Homatropine hydrobromide (R,S) [51-56-9]; Up 200; 11.2uM; PC3; HT_HG-U133A	TNK1 KIDINS220 SELENBP1 LRRC61 ASPSCR1 TTC38 TOR1AIP1	1.02e-05	198	86	7	1806_UP
Drug	Maprotiline hydrochloride [10347-81-6]; Down 200; 12.8uM; PC3; HT_HG-U133A	KCTD12 ZNF219 CELSR3 PLEKHO2 NBEAL2 ASPSCR1 RYR2	1.09e-05	200	86	7	6676_DN
Drug	2-hydroxycarbazole	RYR1 RYR2	4.22e-05	3	86	2	CID000093551
Drug	cis-diammineplatinum(II	RYR1 RYR2	4.22e-05	3	86	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR2	4.22e-05	3	86	2	CID002750949
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR2	4.22e-05	3	86	2	CID005748312
Drug	8N3-cADPR	RYR1 RYR2	4.22e-05	3	86	2	CID000127713
Drug	aminodantrolene	RYR1 RYR2	4.22e-05	3	86	2	CID009570289
Drug	Methiothepin maleate [19728-88-2]; Up 200; 8.4uM; MCF7; HT_HG-U133A	MYO7A PLEKHO2 NBEAL2 AP5Z1 ASPSCR1 ME1	8.19e-05	189	86	6	5413_UP
Drug	PCB74	RYR1 RYR2	8.42e-05	4	86	2	CID000036218
Drug	148504-47-6	RYR1 RYR2	8.42e-05	4	86	2	CID006444275
Drug	SC 38249	RYR1 RYR2	8.42e-05	4	86	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR2	8.42e-05	4	86	2	CID000035682
Drug	clozapine; Down 200; 10uM; HL60; HT_HG-U133A	ZNF219 MYO7A LRP6 ASPSCR1 RYR2 ARAP1	8.93e-05	192	86	6	6188_DN
Drug	ICI 182,780; Up 200; 1uM; MCF7; HT_HG-U133A	AP5Z1 NLRX1 LRRC61 GTF2IRD1 ARAP1 SMG6	9.73e-05	195	86	6	1630_UP
Drug	Acetylsalicylsalicylic acid [530-75-6]; Down 200; 13.4uM; MCF7; HT_HG-U133A	NR2C1 NLRX1 LRP6 LRRC61 ASPSCR1 TTC38	9.73e-05	195	86	6	2223_DN
Drug	Cefamandole sodium salt [30034-03-8]; Down 200; 8.2uM; MCF7; HT_HG-U133A	ZNF219 ELOA2 AP5Z1 LRP6 TTC38 SMG6	1.00e-04	196	86	6	4718_DN
Drug	Florfenicol [73231-34-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	NR2C1 PLEKHO2 KLHL21 LRP6 LRRC61 ARAP1	1.00e-04	196	86	6	6460_DN
Drug	Hydroflumethiazide [135-09-1]; Up 200; 12uM; MCF7; HT_HG-U133A	KCTD12 NR2C1 GTF3C2 LRRC61 RYR2 ARAP1	1.00e-04	196	86	6	1687_UP
Drug	Diethylcarbamazine citrate [1642-54-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A	TNK1 ZNF219 KIDINS220 CELSR3 PLEKHO2 RYR2	1.03e-04	197	86	6	7425_DN
Drug	Spiramycin [8025-81-8]; Down 200; 4.8uM; HL60; HT_HG-U133A	NR2C1 ELOA2 CELSR3 EFCAB2 RYR2 ARAP1	1.03e-04	197	86	6	2558_DN
Drug	Mephenesin [59-47-2]; Down 200; 22uM; MCF7; HT_HG-U133A	CELSR3 PTPRS PLEKHO2 LRP6 RYR2 ARAP1	1.03e-04	197	86	6	2304_DN
Drug	Isocarboxazid [59-63-2]; Up 200; 17.2uM; MCF7; HT_HG-U133A	CELSR1 NLRX1 LRP6 DICER1 RYR1 RYR2	1.06e-04	198	86	6	3424_UP
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; MCF7; HT_HG-U133A	USP2 VPS39 LRP6 SOCS1 LRRC61 TTC38	1.06e-04	198	86	6	6031_DN
Drug	Diphenylpyraline hydrochloride [132-18-3]; Down 200; 12.6uM; MCF7; HT_HG-U133A	KCTD12 PLEKHO2 KLHL21 NLRX1 LRP6 TTC38	1.09e-04	199	86	6	4765_DN
Drug	wortmannin from Penicillium funiculosum; Down 200; 0.01uM; MCF7; HT_HG-U133A	KLHL21 NBEAL2 LRP6 UTP20 LRRC61 ASPSCR1	1.12e-04	200	86	6	7002_DN
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2	2.28e-05	3	82	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2	2.28e-05	3	82	2	DOID:8545 (implicated_via_orthology)
Disease	Usher syndrome, type 1A	MYO7A CDH23	7.59e-05	5	82	2	C2931205
Disease	USHER SYNDROME, TYPE IB (disorder)	MYO7A CDH23	7.59e-05	5	82	2	C1848638
Disease	USHER SYNDROME, TYPE IA, FORMERLY	MYO7A CDH23	7.59e-05	5	82	2	C1848639
Disease	USHER SYNDROME, TYPE I, FRENCH VARIETY, FORMERLY	MYO7A CDH23	7.59e-05	5	82	2	C1848640
Disease	Usher syndrome type 1	MYO7A CDH23	7.59e-05	5	82	2	cv:C1568247
Disease	Usher Syndrome, Type I	MYO7A CDH23	1.14e-04	6	82	2	C1568247
Disease	Hereditary retinal dystrophy	MYO7A CDH23	1.59e-04	7	82	2	C0154860
Disease	Usher syndrome	MYO7A CDH23	1.59e-04	7	82	2	cv:C0271097
Disease	Ciliopathies	MYO7A DYNC2H1 CDH23 NODAL	2.56e-04	110	82	4	C4277690
Disease	complement factor H-like 1 protein measurement	FREM2 KCNT2	1.70e-03	22	82	2	EFO_0600092
Disease	waist-hip ratio	SPATA17 KIDINS220 ZBTB7C KCNT2 DYNC2H1 PTPRS EFR3B ASPSCR1 ACTRT2 SMG6	2.09e-03	1226	82	10	EFO_0004343
Disease	migraine disorder, pulse pressure measurement	DYNC2H1 SMG6	2.37e-03	26	82	2	EFO_0005763, MONDO_0005277

Protein segments in the cluster

Peptide	Gene	Start	Entry
RPDLEIYKPGLSRLR	SMG6	46	Q86US8
LPDRILDAPEIRNDY	CDC20	171	Q12834
ERYPKVALRVLFPDR	ASPSCR1	386	Q9BZE9
SRLLRYQPLERLPLA	AURKC	271	Q9UQB9
LSRRPEEVLREYKLP	ACTRT2	231	Q8TDY3
RREPAYPALRALANE	AJM1	131	C9J069
LPPLLRDYLLLRVEG	ASB16	436	Q96NS5
KREPYEGLRPQDLRR	ANKIB1	221	Q9P2G1
LLPPRERLREVAFEY	AP5Z1	286	O43299
LEYNPDRDPGDRLIR	ATAD2	1061	Q6PL18
TLGQLLPERYDPDRR	CELSR1	2346	Q9NYQ6
NRPALRLDRPLDFYE	CDHR5	181	Q9HBB8
LPDELNFRRRKLYPP	DICER1	781	Q9UPY3
NRPLDRERIPEYKLT	CDH23	1911	Q9H251
NPENPRIARRDYDLL	CDH23	1931	Q9H251
ALRPRYKRLVDNIFP	EFR3A	11	Q14156
NPAILRALDPYKPRR	ADAMTS15	181	Q8TE58
LDPRRDYATAVPRLL	TFAP2E	126	Q6VUC0
YRPLAPELRARQLEL	RCCD1	151	A6NED2
IPLIYLENPRRNRIA	PZP	161	P20742
PDDTYRLSRLLLRLP	NR2C1	541	P13056
PRELGDRARLVSPLY	MDGA1	811	Q8NFP4
QRLLLLDYPPDRVTL	PLOD3	316	O60568
EQYLRLPDAPEQRLR	ELOA2	606	Q8IYF1
LERKYRPIPEDVLLR	EFCAB2	221	Q5VUJ9
LLLRNPKDGRLLYRP	KIDINS220	386	Q9ULH0
VPLPEGLLRQRYREE	FAM156A	56	Q8NDB6
ELLKDPLYIGLRQRR	ME1	201	P48163
LPCLEYLRLRDPLAR	LRRC61	121	Q9BV99
YLRLRDPLARLSNPL	LRRC61	126	Q9BV99
YLRAQLLPQPARRLD	KATNIP	1366	O60303
PSRDRVRLQLRYDAP	FREM2	146	Q5SZK8
LLRRPLYRNLLRSPN	NCCRP1	96	Q6ZVX7
LRPRYKRLVDNIFPE	EFR3B	11	Q9Y2G0
LLRAAPLLLYANRRD	LRP6	16	O75581
PLLLYANRRDLRLVD	LRP6	21	O75581
EYPLDIPLNTRRLFL	LRRC52	46	Q8N7C0
LPPRYRFRDLLLGDQ	KCNT2	11	Q6UVM3
FRRALQRPDDRIPFL	NLRX1	16	Q86UT6
YELNVLPPTARRSRL	NEURL2	176	Q9BR09
LRIQPLRTPRDENVY	PTPRS	91	Q13332
IFVLEYQRLPRRPGE	NPC1L1	716	Q9UHC9
GVEPVLYPLLRRDLV	DYNC2H1	3331	Q8NCM8
LYPLLRRDLVAQGPR	DYNC2H1	3336	Q8NCM8
EQLERLPLARLLRYL	KLHL21	171	Q9UJP4
LPLARLLRYLRDDGL	KLHL21	176	Q9UJP4
VYLLPPAREQLNLRE	IGHM	331	P01871
PVLYQPHLEALDRRL	FAM20C	536	Q8IXL6
SDANLYRLLDLDPRP	CAMP	51	P49913
YDPVLNPVLNREVRR	DYNC1H1	3641	Q14204
YALRIRAQDAGRPPL	CELSR3	616	Q9NYQ7
RASVVPLPYERLLRE	GTF2IRD1	146	Q9UHL9
RNPRLVPYRLLDEAT	RYR1	1016	P21817
NRRNPRLVPYTLLDD	RYR2	1026	Q92736
LRDLQLVLPDYFPER	KCTD12	96	Q96CX2
LVLPDYFPERSRLQR	KCTD12	101	Q96CX2
DLLPQDAPGYRQRLR	NOA1	251	Q8NC60
VPRQRLDLLPFYARL	UPF2	611	Q9HAU5
QLQLPLSRRRRYSDP	INAFM1	106	C9JVW0
PVLYCLLRREPRQAL	RXFP4	306	Q8TDU9
ICPDRQLRRYLVLEP	STK11IP	621	Q8N1F8
LEQRYRPLEPTLRVA	SPATA17	251	Q96L03
PHVLPYRENLQRLLE	UTP20	966	O75691
EYPRLLRNRRELFIA	SLC6A1	411	P30531
YRLDPESPVRILNLR	SSPOP	5106	A2VEC9
SLYRDPLPRADIIRS	NODAL	46	Q96S42
PLVRTLLDRAYEPLG	NBEAL2	1666	Q6ZNJ1
DEAYLKRRPLELPRG	SHISA7	331	A6NL88
DLRQYDISDPQRPRL	SELENBP1	331	Q13228
LARIPLNPVLRDYLS	SOCS1	191	O15524
KRSPRPQDLIRLYDI	SRP68	416	Q9UHB9
RYRELLVRLPPVNRA	ARAP1	1066	Q96P48
ILAGPDAYRDLPRLL	CDK5RAP1	201	Q96SZ6
LRAGQYPRALELLLR	SNX20	196	Q7Z614
YPRALELLLRVLPLQ	SNX20	201	Q7Z614
KQPPERELSRLRRLY	MRPS18B	206	Q9Y676
SEDLVIRLRRPPLRY	TOR1AIP1	186	Q5JTV8
RYPRKRNSLIELPDD	UBR1	1586	Q8IWV7
QLRERDYRQEDLPPL	PRAG1	1276	Q86YV5
ALYLLRRDQRLPPDA	TNFRSF4	236	P43489
PDRVLELLLPIRYRI	TTC38	391	Q5R3I4
LRENLYPKANIPDRR	ZBTB7C	231	A1YPR0
GVPPYLILQRLEDRA	TNK1	326	Q13470
RPVERRFPIYKADLI	GTF3C2	746	Q8WUA4
HPLQPRERLYRAQLE	PLEKHO2	401	Q8TD55
RGSPVERLYLPRNEL	TPTE2P1	36	Q5T6R2
LVNPRVLRTDPRYED	ZDHHC11B	196	P0C7U3
LLDYDRGRPLLRPDI	USP2	71	O75604
PGRLLRTDRQPLREY	USP40	1031	Q9NVE5
ERREPPSLLGYLSLR	ZNF219	371	Q9P2Y4
NAPYRDRIPLRIVRA	TRPC4	11	Q9UBN4
LPRYVEIRTFEPRLL	VPS39	261	Q96JC1
RLPLLPREYLVQRVE	KLHL2	246	O95198
LERLLNLVPTYIPDR	MYO7A	1406	Q13402