Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ceramide-1-phosphate phosphatase activity	PLPP1 PLPP2	2.93e-05	3	63	2	GO:0106235
GeneOntologyMolecularFunction	cholesterol-protein transferase activity	SHH IHH	2.93e-05	3	63	2	GO:0140853
GeneOntologyMolecularFunction	sphingosine-1-phosphate phosphatase activity	PLPP1 PLPP2	2.04e-04	7	63	2	GO:0042392
GeneOntologyMolecularFunction	patched binding	SHH IHH	2.71e-04	8	63	2	GO:0005113
GeneOntologyBiologicalProcess	phospholipid dephosphorylation	PLPP1 PLPP2 MTMR3 INPP5J	9.18e-06	44	62	4	GO:0046839
GeneOntologyBiologicalProcess	intein-mediated protein splicing	SHH IHH	2.66e-05	3	62	2	GO:0016539
GeneOntologyBiologicalProcess	protein splicing	SHH IHH	2.66e-05	3	62	2	GO:0030908
HumanPheno	Abnormal circulating follicle-stimulating hormone concentration	GCNA ERCC6 PIK3CA ZFPM2 MAP3K1	7.16e-05	89	26	5	HP:0030346
HumanPheno	Azoospermia	GCNA FLT4 ERCC6 TRIM32 PIK3CA FDFT1 DHCR7 PRMT7 KAT6B CPLANE1 NDUFB7 ZFPM2 MAP3K1 WDR62 ZNF513	1.19e-04	1157	26	15	HP:0000027
HumanPheno	Elevated circulating follicle stimulating hormone level	GCNA ERCC6 ZFPM2 MAP3K1	1.52e-04	55	26	4	HP:0008232
HumanPheno	Abnormal spermatogenesis	GCNA FLT4 ERCC6 TRIM32 PIK3CA FDFT1 DHCR7 PRMT7 KAT6B CPLANE1 NDUFB7 ZFPM2 MAP3K1 WDR62 ZNF513	1.68e-04	1190	26	15	HP:0008669
HumanPheno	Cryptorchidism	FLT4 ERCC6 TRIM32 FDFT1 DHCR7 PRMT7 KAT6B CPLANE1 NDUFB7 ZFPM2 MAP3K1 WDR62	1.85e-04	780	26	12	HP:0000028
HumanPheno	Brachydactyly	FLT4 TRIM32 PIK3CA DHCR7 SHH IHH PRMT7 KAT6B CPLANE1 ZFPM2 RYR3	2.22e-04	670	26	11	HP:0001156
HumanPheno	Short digit	FLT4 TRIM32 PIK3CA DHCR7 SHH IHH PRMT7 KAT6B CPLANE1 ZFPM2 RYR3	2.28e-04	672	26	11	HP:0011927
HumanPheno	Abnormality of the lower urinary tract	FLT4 ERCC6 TRIM32 PIK3CA FDFT1 DHCR7 PRMT7 KAT6B NDUFB7 ZFPM2 MAP3K1 WDR62 SLC3A1	2.46e-04	937	26	13	HP:0010936
HumanPheno	Deviation of the hand or of fingers of the hand	FLT4 TRIM32 PIK3CA DHCR7 SHH IHH KAT6B CPLANE1 ZFPM2 RYR3	2.61e-04	564	26	10	HP:0009484
HumanPheno	Abnormal male internal genitalia morphology	GCNA FLT4 ERCC6 TRIM32 PIK3CA FDFT1 DHCR7 PRMT7 KAT6B CPLANE1 NDUFB7 ZFPM2 MAP3K1 WDR62 ZNF513	2.82e-04	1243	26	15	HP:0000022
HumanPheno	Renal hypoplasia/aplasia	NADSYN1 ERCC6 PIK3CA DHCR7 SHH PRMT7 CPLANE1 WDR62	2.85e-04	359	26	8	HP:0008678
HumanPheno	Abnormal long bone morphology	NADSYN1 ERCC6 FDFT1 DHCR7 SNX10 SHH IHH PRMT7 KAT6B CPLANE1 WDR62 CRTAP	3.04e-04	821	26	12	HP:0011314
HumanPheno	Abnormal knee morphology	ERCC6 PIK3CA FDFT1 SHH IHH PRMT7 KAT6B WDR62	3.13e-04	364	26	8	HP:0034669
HumanPheno	Decreased serum testosterone concentration	GCNA PIK3CA ZFPM2 MAP3K1	3.29e-04	67	26	4	HP:0040171
HumanPheno	Functional abnormality of male internal genitalia	GCNA FLT4 ERCC6 TRIM32 PIK3CA FDFT1 DHCR7 PRMT7 KAT6B CPLANE1 NDUFB7 ZFPM2 MAP3K1 WDR62 ZNF513	3.61e-04	1269	26	15	HP:0000025
HumanPheno	Abnormality of the male genitalia	GCNA FLT4 ERCC6 TRIM32 PIK3CA FDFT1 DHCR7 SHH PRMT7 KAT6B CPLANE1 NDUFB7 ZFPM2 MAP3K1 WDR62 ZNF513	3.86e-04	1437	26	16	HP:0010461
HumanPheno	Clitoral hypertrophy	DHCR7 KAT6B ZFPM2 MAP3K1	3.89e-04	70	26	4	HP:0008665
HumanPheno	Abnormal size of the clitoris	DHCR7 KAT6B ZFPM2 MAP3K1	3.89e-04	70	26	4	HP:0040252
HumanPheno	Increased size of the clitoris	DHCR7 KAT6B ZFPM2 MAP3K1	3.89e-04	70	26	4	HP:0040253
HumanPheno	Decreased circulating androgen concentration	GCNA PIK3CA ZFPM2 MAP3K1	3.89e-04	70	26	4	HP:0030349
HumanPheno	Abnormal circulating gonadotropin concentration	GCNA ERCC6 PIK3CA ZFPM2 MAP3K1	3.99e-04	128	26	5	HP:0030338
HumanPheno	Abnormal testis morphology	FLT4 ERCC6 TRIM32 PIK3CA FDFT1 DHCR7 PRMT7 KAT6B CPLANE1 NDUFB7 ZFPM2 MAP3K1 WDR62 ZNF513	4.07e-04	1129	26	14	HP:0000035
HumanPheno	Gray matter heterotopia	PIK3CA DHCR7 KAT6B CPLANE1 WDR62	4.13e-04	129	26	5	HP:0002282
HumanPheno	Non-obstructive azoospermia	FLT4 ERCC6 TRIM32 PIK3CA FDFT1 DHCR7 PRMT7 KAT6B CPLANE1 NDUFB7 ZFPM2 MAP3K1 WDR62 ZNF513	4.19e-04	1132	26	14	HP:0011961
HumanPheno	Renal agenesis	NADSYN1 ERCC6 DHCR7 SHH CPLANE1 WDR62	5.13e-04	209	26	6	HP:0000104
HumanPheno	Abnormal morphology of the great vessels	FLT4 NADSYN1 ERCC6 PIK3CA DHCR7 SNX10 SHH KAT6B CPLANE1 ZFPM2 CRTAP	5.15e-04	736	26	11	HP:0030962
HumanPheno	Abnormal male reproductive system physiology	GCNA FLT4 ERCC6 TRIM32 PIK3CA FDFT1 DHCR7 PRMT7 KAT6B CPLANE1 NDUFB7 ZFPM2 MAP3K1 WDR62 ZNF513	5.43e-04	1314	26	15	HP:0012874
HumanPheno	Dysplastic corpus callosum	RELN ERCC6 DHCR7 SHH KAT6B CPLANE1 NDUFB7 WDR62	5.47e-04	395	26	8	HP:0006989
HumanPheno	Hypolipidemia	GCNA PIK3CA ZFPM2 MAP3K1	5.61e-04	77	26	4	HP:0045014
HumanPheno	Abnormal circulating luteinizing hormone concentration	GCNA PIK3CA ZFPM2 MAP3K1	5.61e-04	77	26	4	HP:0030345
HumanPheno	Aplasia/Hypoplasia of the patella	SHH PRMT7 KAT6B	5.82e-04	33	26	3	HP:0006498
HumanPheno	Abnormal male external genitalia morphology	FLT4 ERCC6 TRIM32 PIK3CA FDFT1 DHCR7 SHH PRMT7 KAT6B CPLANE1 NDUFB7 ZFPM2 MAP3K1 WDR62 ZNF513	6.19e-04	1329	26	15	HP:0000032
HumanPheno	Prenatal growth deficiency	RELN FLT4 ERCC6 FDFT1 DHCR7 SHH PRMT7 NDUFB7 ZFPM2 CRTAP	6.55e-04	631	26	10	HP:0001515
HumanPheno	Intrauterine growth retardation	RELN FLT4 ERCC6 FDFT1 DHCR7 SHH PRMT7 NDUFB7 ZFPM2 CRTAP	6.55e-04	631	26	10	HP:0001511
MousePheno	pulmonary hypoplasia	DHCR7 SHH MAPK6 CPLANE1 ZFPM2	9.65e-07	54	47	5	MP:0001178
MousePheno	abnormal lymphangiogenesis	FLT4 PIK3CA AWAT2	1.58e-05	15	47	3	MP:0008778
MousePheno	annular pancreas	SHH IHH	3.31e-05	3	47	2	MP:0006261
MousePheno	small lung	DHCR7 SHH MAPK6 CPLANE1 ZFPM2	4.02e-05	115	47	5	MP:0003641
MousePheno	fetal growth retardation	PIK3CA DHCR7 SHH WDR62 CRTAP	4.19e-05	116	47	5	MP:0004201
MousePheno	abnormal fetal growth/weight/body size	PIK3CA DHCR7 SHH MAPK6 IHH WDR62 CRTAP	7.54e-05	312	47	7	MP:0004197
MousePheno	abnormal lung saccule morphology	DHCR7 SHH MAPK6	1.22e-04	29	47	3	MP:0010825
MousePheno	abnormal perineural vascular plexus morphology	FLT4 PIK3CA	1.65e-04	6	47	2	MP:0012732
Domain	INTEIN_N_TER	SHH IHH	1.08e-05	2	62	2	PS50817
Domain	Intein_N	SHH IHH	1.08e-05	2	62	2	IPR006141
Domain	Hedgehog_sig/DD-Pept_Zn-bd_dom	SHH IHH	3.25e-05	3	62	2	IPR009045
Domain	Hedgehog_signalling_dom	SHH IHH	3.25e-05	3	62	2	IPR000320
Domain	HintN	SHH IHH	3.25e-05	3	62	2	SM00306
Domain	HintC	SHH IHH	3.25e-05	3	62	2	SM00305
Domain	Hedgehog	SHH IHH	3.25e-05	3	62	2	IPR001657
Domain	Hint_dom	SHH IHH	3.25e-05	3	62	2	IPR001767
Domain	-	SHH IHH	3.25e-05	3	62	2	3.30.1380.10
Domain	Hint_dom_N	SHH IHH	3.25e-05	3	62	2	IPR003587
Domain	Hint_dom_C	SHH IHH	3.25e-05	3	62	2	IPR003586
Domain	HH_signal	SHH IHH	3.25e-05	3	62	2	PF01085
Domain	Hint	SHH IHH	3.25e-05	3	62	2	PF01079
Domain	-	SHH IHH	6.48e-05	4	62	2	2.170.16.10
Domain	Hedgehog/Intein_dom	SHH IHH	6.48e-05	4	62	2	IPR028992
Domain	-	PLPP1 PLPP2	1.60e-03	18	62	2	1.20.144.10
Domain	acidPPc	PLPP1 PLPP2	1.60e-03	18	62	2	SM00014
Domain	P_Acid_Pase_2/haloperoxidase	PLPP1 PLPP2	1.98e-03	20	62	2	IPR000326
Domain	PAP2	PLPP1 PLPP2	1.98e-03	20	62	2	PF01569
Domain	-	NOCT INPP5J	3.35e-03	26	62	2	3.60.10.10
Domain	Exo_endo_phos	NOCT INPP5J	3.35e-03	26	62	2	PF03372
Domain	Endo/exonuclease/phosphatase	NOCT INPP5J	3.61e-03	27	62	2	IPR005135
Domain	PSI	ATRN PLXNA4	5.04e-03	32	62	2	PF01437
Domain	Plexin_repeat	ATRN PLXNA4	5.04e-03	32	62	2	IPR002165
Domain	PSI	ATRN PLXNA4	9.38e-03	44	62	2	IPR016201
Pathway	PID_HEDGEHOG_2PATHWAY	PIK3CA SHH IHH	5.80e-05	22	49	3	M211
Pathway	REACTOME_FORMATION_OF_LATERAL_PLATE_MESODERM	SHH IHH	1.18e-04	5	49	2	M46432
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_HH_LIGAND_SECRETION	SHH IHH	1.76e-04	6	49	2	M47892
Pathway	REACTOME_METABOLISM_OF_LIPIDS	ARSH PLPP1 PLPP2 PIK3CA FDFT1 DHCR7 SRD5A1 MTMR3 AWAT2 INPP5J	2.29e-04	757	49	10	M27451
Pathway	REACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL	SHH IHH	2.46e-04	7	49	2	MM15187
Pathway	REACTOME_LIGAND_RECEPTOR_INTERACTIONS	SHH IHH	2.46e-04	7	49	2	MM15224
Pathway	REACTOME_METABOLISM_OF_LIPIDS	PLPP1 PLPP2 PIK3CA FDFT1 DHCR7 SRD5A1 MTMR3 AWAT2 INPP5J	2.46e-04	620	49	9	MM15193
Pathway	REACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL	SHH IHH	3.27e-04	8	49	2	M27444
Pathway	REACTOME_LIGAND_RECEPTOR_INTERACTIONS	SHH IHH	3.27e-04	8	49	2	M27496
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_PTCH_CORECEPTOR	SHH IHH	4.20e-04	9	49	2	M47893
Pubmed	The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning.	PLPP1 PLPP2 SHH	9.25e-07	11	63	3	12925589
Pubmed	Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog.	VIL1 SHH IHH	1.23e-06	12	63	3	7590746
Pubmed	Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation.	RELN FLT4 ITGA9	2.03e-06	14	63	3	22665518
Pubmed	Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.	SHH IHH	3.23e-06	2	63	2	28574612
Pubmed	Opposite expression patterns of Sonic hedgehog and Indian hedgehog are associated with aberrant methylation status of their promoters in colorectal cancers.	SHH IHH	3.23e-06	2	63	2	20854074
Pubmed	Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis.	SHH IHH	3.23e-06	2	63	2	23468532
Pubmed	Cholesterol modification of hedgehog signaling proteins in animal development.	SHH IHH	3.23e-06	2	63	2	8824192
Pubmed	Hedgehog can drive terminal differentiation of amniote slow skeletal muscle.	SHH IHH	3.23e-06	2	63	2	15238161
Pubmed	Identification of a novel human phosphatidic acid phosphatase type 2 isoform.	PLPP1 PLPP2	3.23e-06	2	63	2	9607309
Pubmed	Effect of polymorphisms in the NADSYN1/DHCR7 locus (rs12785878 and rs1790349) on plasma 25-hydroxyvitamin D levels and coronary artery disease incidence.	NADSYN1 DHCR7	3.23e-06	2	63	2	24642724
Pubmed	New insight into hedgehog signaling in hematological malignancies.	SHH IHH	3.23e-06	2	63	2	24991722
Pubmed	The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients.	SHH IHH	3.23e-06	2	63	2	26201092
Pubmed	Differential requirements for shh in mammary tissue and hair follicle morphogenesis.	SHH IHH	3.23e-06	2	63	2	12217324
Pubmed	Enrichment of vitamin D response elements in RA-associated loci supports a role for vitamin D in the pathogenesis of RA.	NADSYN1 DHCR7	3.23e-06	2	63	2	23636220
Pubmed	Hedgehog signaling regulates expansion of pancreatic epithelial cells.	SHH IHH	3.23e-06	2	63	2	15766752
Pubmed	Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.	SHH IHH	3.23e-06	2	63	2	29088246
Pubmed	Distinct expression patterns of hedgehog ligands between cultured and primary colorectal cancers are associated with aberrant methylation of their promoters.	SHH IHH	3.23e-06	2	63	2	19856079
Pubmed	Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling.	SHH IHH	3.23e-06	2	63	2	24344235
Pubmed	Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.	PLPP1 PLPP2	3.23e-06	2	63	2	9570154
Pubmed	IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice.	SHH IHH	3.23e-06	2	63	2	36853961
Pubmed	Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.	SHH IHH	3.23e-06	2	63	2	14520411
Pubmed	Increased production of sonic hedgehog by ballooned hepatocytes.	SHH IHH	3.23e-06	2	63	2	21547909
Pubmed	alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway.	RELN SHH IHH	5.38e-06	19	63	3	16543460
Pubmed	Vitamin D Deficiency in Uygurs and Kazaks Is Associated with Polymorphisms in CYP2R1 and DHCR7/NADSYN1 Genes.	NADSYN1 DHCR7	9.68e-06	3	63	2	26149120
Pubmed	Hedgehog signaling maintains resident hepatic progenitors throughout life.	SHH IHH	9.68e-06	3	63	2	16322088
Pubmed	Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels.	SHH IHH	9.68e-06	3	63	2	21537345
Pubmed	[Hedgehog signaling pathway and its impact on development of cancer therapy].	SHH IHH	9.68e-06	3	63	2	18788453
Pubmed	Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation.	SHH IHH	9.68e-06	3	63	2	19109233
Pubmed	Correlation Between Hedgehog (Hh) Protein Family and Brain-Derived Neurotrophic Factor (BDNF) in Autism Spectrum Disorder (ASD).	SHH IHH	9.68e-06	3	63	2	26691363
Pubmed	The adventures of Sonic Hedgehog in development and repair. I. Hedgehog signaling in gastrointestinal development and disease.	SHH IHH	9.68e-06	3	63	2	18063705
Pubmed	Associations between polymorphisms related to calcium metabolism and human height: the Tromsø Study.	NADSYN1 DHCR7	9.68e-06	3	63	2	22390397
Pubmed	Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.	PLPP1 PLPP2	9.68e-06	3	63	2	9705349
Pubmed	SNP variants at the MAP3K1/SETD9 locus 5q11.2 associate with somatic PIK3CA variants in breast cancers.	PIK3CA MAP3K1	9.68e-06	3	63	2	28029147
Pubmed	Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase.	PLPP1 PLPP2	9.68e-06	3	63	2	12471011
Pubmed	The hedgehog signaling pathway in the mouse ovary.	SHH IHH	9.68e-06	3	63	2	17392501
Pubmed	The world according to hedgehog.	SHH IHH	9.68e-06	3	63	2	9009843
Pubmed	Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.	PLPP1 PLPP2	9.68e-06	3	63	2	18215144
Pubmed	Hedgehog signal transduction: from flies to vertebrates.	SHH IHH	9.68e-06	3	63	2	10579908
Pubmed	Genetic variants of vitamin D metabolism-related DHCR7/NADSYN1 locus and CYP2R1 gene are associated with clinical features of Parkinson's disease.	NADSYN1 DHCR7	9.68e-06	3	63	2	32938288
Pubmed	Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation.	SHH MAP3K1	9.68e-06	3	63	2	30483764
Pubmed	The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides.	SHH IHH	9.68e-06	3	63	2	11476578
Pubmed	The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis.	PIK3CA INPP5J	9.68e-06	3	63	2	26267533
Pubmed	QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis.	PIK3CA QPCT	9.68e-06	3	63	2	34036385
Pubmed	Association study of hypertension susceptibility genes ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han population.	CACNB2 ITGA9	9.68e-06	3	63	2	33491517
Pubmed	Shh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development.	WNT11 SHH	9.68e-06	3	63	2	19014928
Pubmed	Genetic mosaic analysis reveals that GATA-4 is required for proper differentiation of mouse gastric epithelium.	SHH IHH	9.68e-06	3	63	2	11784093
Pubmed	Dhcr7 Regulates Palatal Shelf Fusion through Regulation of Shh and Bmp2 Expression.	DHCR7 SHH	9.68e-06	3	63	2	27066502
Pubmed	Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway.	PIK3CA SHH	9.68e-06	3	63	2	22875023
Pubmed	Developmental mechanisms underlying polydactyly in the mouse mutant Doublefoot.	SHH IHH	9.68e-06	3	63	2	12587916
Pubmed	A new role for Hedgehogs in juxtacrine signaling.	SHH IHH	9.68e-06	3	63	2	24342078
Pubmed	Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades.	FLT4 ITGA9	9.68e-06	3	63	2	17287396
Pubmed	Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target.	SHH IHH	9.68e-06	3	63	2	19074837
Pubmed	Evolution of the hedgehog gene family.	SHH IHH	9.68e-06	3	63	2	8849902
Pubmed	Comparative biological responses to human Sonic, Indian, and Desert hedgehog.	SHH IHH	9.68e-06	3	63	2	11472839
Pubmed	Atmin mediates kidney morphogenesis by modulating Wnt signaling.	WNT11 SHH IHH	1.12e-05	24	63	3	24852369
Pubmed	GATA6 is a crucial regulator of Shh in the limb bud.	SHH IHH ZFPM2	1.43e-05	26	63	3	24415953
Pubmed	Expression of GLI1 correlates with expression of lymphangiogenesis proteins, vascular endothelial growth factor C and vascular endothelial growth factor receptor 3, in colorectal cancer.	FLT4 SHH	1.93e-05	4	63	2	23336661
Pubmed	Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer.	SHH IHH	1.93e-05	4	63	2	22486854
Pubmed	Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina.	SHH IHH	1.93e-05	4	63	2	9053312
Pubmed	Downregulation of hedgehog ligands in human simple steatosis may protect against nonalcoholic steatohepatitis: Is TAZ a crucial regulator?	SHH IHH	1.93e-05	4	63	2	31087761
Pubmed	Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite.	SHH IHH	1.93e-05	4	63	2	11572986
Pubmed	TMEM147 interacts with lamin B receptor, regulates its localization and levels, and affects cholesterol homeostasis.	TMEM47 DHCR7	1.93e-05	4	63	2	32694168
Pubmed	Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis.	SHH IHH	1.93e-05	4	63	2	12917489
Pubmed	Genetic disorders of cholesterol biosynthesis in mice and humans.	FDFT1 DHCR7	1.93e-05	4	63	2	11592808
Pubmed	Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.	SHH IHH	1.93e-05	4	63	2	8595881
Pubmed	Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species.	SHH IHH	1.93e-05	4	63	2	32108165
Pubmed	Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.	FLT4 PIK3CA	1.93e-05	4	63	2	32513927
Pubmed	Characterization of the chromosome 1q41q42.12 region, and the candidate gene DISP1, in patients with CDH.	SHH IHH	1.93e-05	4	63	2	20799323
Pubmed	RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression.	RELN PIK3CA	1.93e-05	4	63	2	27071537
Pubmed	A recurrent ITGA9 missense mutation in human fetuses with severe chylothorax: possible correlation with poor response to fetal therapy.	FLT4 ITGA9	1.93e-05	4	63	2	18973153
Pubmed	Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.	SHH IHH	1.93e-05	4	63	2	7916661
Pubmed	Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors.	SHH IHH	1.93e-05	4	63	2	27694322
Pubmed	Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis.	SHH IHH	1.93e-05	4	63	2	9858693
Pubmed	SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning.	FDFT1 DHCR7 SHH	2.00e-05	29	63	3	34822715
Pubmed	Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.	FDFT1 DHCR7 SHH	2.46e-05	31	63	3	19796621
Pubmed	Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.	PLXNA4 AGBL1 MAP3K1	2.97e-05	33	63	3	24204828
Pubmed	Functional compensation in Hedgehog signaling during mouse prostate development.	SHH IHH	3.22e-05	5	63	2	16707121
Pubmed	Shh expression is required for embryonic hair follicle but not mammary gland development.	SHH IHH	3.22e-05	5	63	2	14623238
Pubmed	Developmental pathways in breast cancer and breast tumor-initiating cells: therapeutic implications.	SHH IHH	3.22e-05	5	63	2	22123293
Pubmed	Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells.	SHH IHH	3.22e-05	5	63	2	19559697
Pubmed	Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein.	SHH IHH	3.22e-05	5	63	2	10050855
Pubmed	All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.	SHH IHH	3.22e-05	5	63	2	20519495
Pubmed	Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice.	FLT4 ITGA9	3.22e-05	5	63	2	21765212
Pubmed	An Nfic-hedgehog signaling cascade regulates tooth root development.	SHH IHH	3.22e-05	5	63	2	26293299
Pubmed	The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development.	SHH IHH	3.22e-05	5	63	2	10804186
Pubmed	Products, genetic linkage and limb patterning activity of a murine hedgehog gene.	SHH IHH	3.22e-05	5	63	2	7720571
Pubmed	Hedgehog and patched gene expression in adult ocular tissues.	SHH IHH	3.22e-05	5	63	2	9237688
Pubmed	Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.	FLT4 PIK3CA	3.22e-05	5	63	2	17540175
Pubmed	Molecular signaling in intervertebral disk development.	SHH IHH	3.22e-05	5	63	2	15936916
Pubmed	Common genetic determinants of vitamin D insufficiency: a genome-wide association study.	NADSYN1 DHCR7	3.22e-05	5	63	2	20541252
Pubmed	β-Catenin gain of function in muscles impairs neuromuscular junction formation.	RELN WNT11 SHH	3.26e-05	34	63	3	22627288
Pubmed	Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.	VIL1 SHH IHH	4.21e-05	37	63	3	23266329
Pubmed	A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.	FDFT1 DHCR7 SHH	4.21e-05	37	63	3	26108225
Pubmed	Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney.	SHH IHH	4.82e-05	6	63	2	12399320
Pubmed	XLMR candidate mouse gene, Zcchc12 (Sizn1) is a novel marker of Cajal-Retzius cells.	RELN SHH	4.82e-05	6	63	2	21172456
Pubmed	Restriction of sonic hedgehog signalling during early tooth development.	SHH IHH	4.82e-05	6	63	2	15151988
Pubmed	Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog.	SHH IHH	4.82e-05	6	63	2	19590577
Pubmed	A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve.	SHH IHH	4.82e-05	6	63	2	10357934
Pubmed	Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate.	SHH IHH	4.82e-05	6	63	2	25362352
Pubmed	A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development.	SHH IHH	4.82e-05	6	63	2	12385751
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	VIL1 ZNF142 ATG9A IHH	3.12e-05	129	63	4	chr2q35
Cytoband	2q35	VIL1 ZNF142 ATG9A	1.81e-04	79	63	3	2q35
Cytoband	2q33.3	MDH1B PLEKHM3	7.86e-04	30	63	2	2q33.3
GeneFamily	Phospholipid phosphatases	PLPP1 PLPP2	1.15e-04	7	43	2	1067
GeneFamily	Zinc fingers C2HC-type\|PHD finger proteins\|Lysine acetyltransferases	KAT6B ZFPM2	6.49e-04	16	43	2	66
GeneFamily	Phosphoinositide phosphatases	MTMR3 INPP5J	2.62e-03	32	43	2	1079
Coexpression	BCAT_GDS748_UP	FLT4 WNT11 QPCT ITGA9	5.45e-06	48	63	4	M2678
Coexpression	BCAT.100_UP.V1_UP	WNT11 QPCT IHH ITGA9	5.92e-06	49	63	4	M2680
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNB2 WNT11 PLXNA4 ITGA9 ZFPM2 RYR3	2.19e-07	181	63	6	25915e2500430a902db37d79a749ce2990b69810
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PIK3CA WNT11 PLXNA4 QPCT ITGA9 ZFPM2	2.49e-07	185	63	6	427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	CACNB2 WNT11 PLXNA4 ITGA9 ZFPM2 RYR3	2.92e-07	190	63	6	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNB2 WNT11 PLXNA4 ITGA9 ZFPM2	6.12e-06	183	63	5	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNB2 WNT11 PLXNA4 ITGA9 ZFPM2	6.12e-06	183	63	5	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN FLT4 FDFT1 DHCR7 AWAT2	6.28e-06	184	63	5	3b0389c3a5a16697de860e98ebc48ed39ede646f
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNB2 PLXNA4 ITGA9 AGBL1 ZFPM2	6.45e-06	185	63	5	e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNB2 WNT11 PLXNA4 ITGA9 ZFPM2	6.80e-06	187	63	5	c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNB2 PLXNA4 ITGA9 AGBL1 ZFPM2	6.97e-06	188	63	5	3177b2c1723268d330d3e9f24f9e24492ace6286
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNB2 PLXNA4 ITGA9 AGBL1 ZFPM2	6.97e-06	188	63	5	293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RELN FLT4 PLPP1 ITGA9 ZFPM2	6.97e-06	188	63	5	aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	CACNB2 WNT11 PLXNA4 ITGA9 ZFPM2	7.16e-06	189	63	5	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RELN FLT4 PLPP1 ITGA9 ZFPM2	7.34e-06	190	63	5	6e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCell	IPF-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	RELN FLT4 PLPP1 ITGA9 ZFPM2	7.34e-06	190	63	5	ac029e73da5995221c9b9af551d85e4b835e21d6
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNB2 WNT11 PLXNA4 ITGA9 ZFPM2	7.53e-06	191	63	5	b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCell	IPF-Endothelial-Lymphatic\|IPF / Disease state, Lineage and Cell class	RELN FLT4 PLPP1 ITGA9 ZFPM2	7.72e-06	192	63	5	2496edd8f3a41146d418879de9ee2ccc7857431f
ToppCell	Control-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	RELN FLT4 PLPP1 ITGA9 ZFPM2	7.72e-06	192	63	5	f95fb188aa642f3d0618242a770e7c4b70544adb
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 TMEM47 PLPP1 SRD5A1 ITGA9	7.72e-06	192	63	5	a42aed9e563f5f4af029b8804c104f11ad227a8f
ToppCell	COPD-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	RELN FLT4 PLPP1 ITGA9 ZFPM2	7.92e-06	193	63	5	25bdc557055b5bce6a21f8696b48e991c696b979
ToppCell	Control-Endothelial-Lymphatic\|Control / Disease state, Lineage and Cell class	RELN FLT4 PLPP1 ITGA9 ZFPM2	7.92e-06	193	63	5	64d19be73e5432d491436a01da5de5c926b615a9
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic-LEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RELN FLT4 PLPP1 ITGA9 ZFPM2	8.12e-06	194	63	5	f772a9f9ef8635aeaeb8b022dbb94e9672b36ead
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic-LEC-LEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RELN FLT4 PLPP1 ITGA9 ZFPM2	8.12e-06	194	63	5	3b73f2d305a7566f7ab567e5f18c82cd3d80e32c
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RELN FLT4 PLPP1 ITGA9 ZFPM2	8.12e-06	194	63	5	5d2b3ed5374e2ab10c1c7eb3a03139fc95036a48
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 TMEM47 PLPP1 ITGA9	8.54e-06	196	63	5	8f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 TMEM47 PLPP1 ITGA9	8.54e-06	196	63	5	48b4a9cea97a55190217deaf51bf867608c5a9a7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 TMEM47 PLPP1 ITGA9	8.54e-06	196	63	5	473980c827443464d08a0be28c53e3536369b12a
ToppCell	P03-Mesenchymal-myocytic_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IL13RA1 WNT11 PLXNA4 QPCT ITGA9	8.75e-06	197	63	5	079db904a08743b3c555cb7b3f5fb5c978dde25a
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	VIL1 CEACAM18 QPCT ITGA9	2.22e-05	116	63	4	f32f7eddfe33adb3b5cf7c34667a481a305c5163
ToppCell	COVID-19-kidney-Lymphatic_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RELN FLT4 ITGA9 ZFPM2	5.76e-05	148	63	4	f777aa1674e898e2594b2b7c029d3d05dda04df9
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNB2 AGBL1 ZFPM2 RYR3	7.61e-05	159	63	4	fd7db2f7328cfefdc3ada2af91006d5a91d137e1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNB2 AGBL1 ZFPM2 RYR3	7.61e-05	159	63	4	aaf449c768d6fbb0a1bb47746ff3bdb7f9eb8914
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNB2 AGBL1 ZFPM2 RYR3	7.61e-05	159	63	4	8bbdef1e927f3130b578d7d7c5ff38bbe06fab63
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	7.98e-05	161	63	4	fb59d96c2aa9e4654f02bf6ce36bf832776cb4dd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	7.98e-05	161	63	4	c53c461fc721a7960cef86662f49e2a495520701
ToppCell	facs-SCAT-Fat-18m-Epithelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIL1 IHH INPP5J SLC3A1	8.18e-05	162	63	4	341fa357ad7bdbef30864e8062f161e60185ffc9
ToppCell	facs-SCAT-Fat-18m-Epithelial-epithelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIL1 IHH INPP5J SLC3A1	8.18e-05	162	63	4	7215f6eb2b65dea455e2eec722a9c38e6958b120
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	8.18e-05	162	63	4	2ac02523348660e514d464f8f2434ee0c312d784
ToppCell	facs-SCAT-Fat-18m-Epithelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIL1 IHH INPP5J SLC3A1	8.18e-05	162	63	4	7fa93efa2039d68a4e8214fa143bcd3368349a2d
ToppCell	facs-Heart-RA-18m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIL1 IHH INPP5J SLC3A1	8.37e-05	163	63	4	13557be854878abc1bcdab909b49b8292d064145
ToppCell	facs-Heart-RA-18m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIL1 IHH INPP5J SLC3A1	8.37e-05	163	63	4	6c1d1646410e785886d2de103b4b12f73e91edff
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	8.57e-05	164	63	4	a784f47f67a5eda84d58ad7d9400e3978edbb487
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	8.57e-05	164	63	4	1a1795969673232191425dde84ab24ee6a98143f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	8.57e-05	164	63	4	8f074940afdbda88a4b697a7ddc687e09a4b818b
ToppCell	Endothelial-B-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	RELN FLT4 PLPP1 ITGA9	8.78e-05	165	63	4	b6893882472aeb0d18e26f47eaec9d53688afcde
ToppCell	facs-Lung-EPCAM-24m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN FLT4 ERLEC1 ZFPM2	9.20e-05	167	63	4	961e722442d786ab15d1e490941d2be265a9057a
ToppCell	COVID-19-kidney-Lymphatic_EC\|kidney / Disease (COVID-19 only), tissue and cell type	RELN FLT4 ITGA9 ZFPM2	9.20e-05	167	63	4	97d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
ToppCell	facs-Lung-EPCAM-24m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN FLT4 ERLEC1 ZFPM2	9.20e-05	167	63	4	3760efc35d4e7e9c2da1a20f9795ddea397e2206
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	9.85e-05	170	63	4	6035c92cd39c5ac54e7ec57d94888ee19f574639
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	9.85e-05	170	63	4	c8c42eda44b61440c96b202e7f54650046eb95d3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	9.85e-05	170	63	4	dcc64b73134e89ae37990d4878813b86ce91dae9
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNB2 WNT11 ITGA9 ZFPM2	1.05e-04	173	63	4	1f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D122\|Adult / Lineage, Cell type, age group and donor	RELN FLT4 ITGA9 ZFPM2	1.05e-04	173	63	4	dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCell	Endothelial-B-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	RELN FLT4 PLPP1 ITGA9	1.05e-04	173	63	4	a81992965137195d20fc498f750975303961a828
ToppCell	TCGA-Adrenal-Primary_Tumor-Adrenocortical_carcinoma-Usual_Type-4\|TCGA-Adrenal / Sample_Type by Project: Shred V9	FDFT1 DHCR7 ITGA9 METTL17	1.08e-04	174	63	4	15e2b9f46404ff9575e149024b24cb17b50b02b5
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN FLT4 MTMR3 ITGA9	1.10e-04	175	63	4	43be63976da5ad0764d24d90919a77ce46068f52
ToppCell	P15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RELN FLT4 ITGA9 RYR3	1.10e-04	175	63	4	84d252f3e432231687613299bbea14978bb4b06b
ToppCell	P15-Endothelial-lymphatic_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RELN FLT4 ITGA9 RYR3	1.10e-04	175	63	4	a00c6fa9b33640710dd05a3799031147196f0986
ToppCell	Control-Neuronal_cells-Neuronal_cells\|Control / group, cell type (main and fine annotations)	RELN FLT4 ITGA9 ZFPM2	1.13e-04	176	63	4	98c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCell	Control-Neuronal_cells\|Control / group, cell type (main and fine annotations)	RELN FLT4 ITGA9 ZFPM2	1.13e-04	176	63	4	c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	1.15e-04	177	63	4	c274fbdc141855ff4581d437d4997c64cc193278
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	1.15e-04	177	63	4	227d4f423b00be2e0c5797e2c5275d342e69a0f4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	1.15e-04	177	63	4	f5e6df5cafd003bbfbb3b634ee58d0b1e2be5cc7
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	1.15e-04	177	63	4	66ffa279147961080c104242a08b176e301d80e3
ToppCell	COVID-19-Heart-Lymph_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RELN FLT4 ITGA9 ZFPM2	1.15e-04	177	63	4	326fde0734ef0d7272693966d346ca479b9d8147
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	1.15e-04	177	63	4	c8a51e480b978dc0ded85583261f2c892e085be8
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	1.15e-04	177	63	4	0cbf54608d2ba0a0500af142f2029fe5e118c3c2
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN FLT4 PLPP2 ITGA9	1.15e-04	177	63	4	6248c0dcad302de61a66163ee84b3b79096150d7
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN FLT4 ITGA9 ZFPM2	1.18e-04	178	63	4	4ef6344d0ffc9c55b1240bee94b741382f1427bb
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN FLT4 ITGA9 ZFPM2	1.18e-04	178	63	4	c65932cbedbbfacb6f0299280663fe7c88dba72b
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D231\|Adult / Lineage, Cell type, age group and donor	RELN FLT4 ITGA9 ZFPM2	1.18e-04	178	63	4	c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RELN FLT4 ITGA9 ZFPM2	1.18e-04	178	63	4	ad3de3e03a401dac64431a541899445262246347
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CACNB2 FRY ZFPM2 RYR3	1.20e-04	179	63	4	7394e77e665bf16d3733df91bb12907be460ab44
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNB2 WNT11 PLXNA4 ITGA9	1.20e-04	179	63	4	02c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNB2 PLXNA4 ITGA9 ZFPM2	1.23e-04	180	63	4	01f2e5d96016823482f89ba503d007d4bd88eeac
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALT2 ERCC6 FDFT1 TMEM39B	1.25e-04	181	63	4	e2d03115a87f45a7ddd3ade6b9ac3843639bd41a
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN FLT4 ANKDD1B MAP3K1	1.25e-04	181	63	4	cef034030e6b029a49ae56be37ea1fac1a5c350e
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNB2 WNT11 PLXNA4 ITGA9	1.25e-04	181	63	4	d7e04e0ca549eac6d9b1192b6578f9b54943d54f
ToppCell	droplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM47 PLPP1 INPP5J CRTAP	1.25e-04	181	63	4	a53f05c4c47465ee62e353716456bd09ab464b23
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALT2 ERCC6 FDFT1 TMEM39B	1.25e-04	181	63	4	d8d11ef83c4b8b6a6f5c8728e03059e45a8ad264
ToppCell	5'-GW_trimst-1-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VIL1 DHCR7 SHH ZFPM2	1.25e-04	181	63	4	c7a220891567c7539ad5a9ac9db375f0de08ea00
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIL1 FLT4 NOCT SLC3A1	1.25e-04	181	63	4	709e9c7a60d5f98635b99895ce30bb87a9f7376d
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN FLT4 PLPP1 ZFPM2	1.28e-04	182	63	4	fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	1.28e-04	182	63	4	41b070085edba7a58b81c20aa4942d06f745acf8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	1.28e-04	182	63	4	5e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN FLT4 ITGA9 ZFPM2	1.28e-04	182	63	4	b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RELN FLT4 ITGA9 ZFPM2	1.28e-04	182	63	4	53c267ee327e116dbd89d5927ed3bdf78d25ee62
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN FLT4 ITGA9 ZFPM2	1.28e-04	182	63	4	fc020d784ab81af80d9331cc322b7c259284eaef
ToppCell	droplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 TMEM47 PLPP1 INPP5J	1.31e-04	183	63	4	709a486154b3157427deb3b8886b63ac39ea42dd
ToppCell	droplet-Liver-nan-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 TMEM47 PLPP1 INPP5J	1.31e-04	183	63	4	dc06f19f6f80f4c7f13f1f990c1fe0f91ba64ea7
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RELN FLT4 ITGA9 ZFPM2	1.31e-04	183	63	4	4d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN FLT4 ZFPM2 RYR3	1.31e-04	183	63	4	919c9861073d12fd12aecd7469b1478b13838c43
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN FLT4 SNX10 ZFPM2	1.34e-04	184	63	4	30ca56d64c961127e26122613e35aa2b46fde2df
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN FLT4 PLPP1 ZFPM2	1.34e-04	184	63	4	453295362888c9a59d0e73c7a5b15914c50ff591
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNB2 PLXNA4 ITGA9 ZFPM2	1.36e-04	185	63	4	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	COVID-19-Neuronal_cells-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	RELN FLT4 ITGA9 ZFPM2	1.36e-04	185	63	4	4a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNB2 PLXNA4 ITGA9 ZFPM2	1.36e-04	185	63	4	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	COVID-19-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	RELN FLT4 ITGA9 ZFPM2	1.36e-04	185	63	4	36ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNB2 ITGA9 AGBL1 ZFPM2	1.39e-04	186	63	4	6add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCell	droplet-Lung-LUNG-30m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN FLT4 ITGA9 ZFPM2	1.39e-04	186	63	4	f23f21781a758541f59c06efa7739d26a03fb478
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RELN FLT4 ITGA9 ZFPM2	1.39e-04	186	63	4	40070d9cd20188ba49b32acfca9bc16256b38bf5
Drug	AC1NS51S	FDFT1 DHCR7 SHH IHH	1.04e-06	28	63	4	CID005354165
Drug	8-dehydrocholesterol	FDFT1 DHCR7 SHH IHH	1.04e-06	28	63	4	CID000129846
Drug	M1-L	FDFT1 DHCR7 SHH IHH	6.65e-06	44	63	4	CID010062733
Drug	androst-5-en-17-one	PLPP1 PLPP2 FDFT1	7.19e-06	14	63	3	CID000151432
Drug	myo-inositol	ARHGAP1 CACNB2 SERPINA4 PLPP1 PLPP2 TRIM32 PIK3CA MTMR3 MAPK6 INPP5J RYR3	1.24e-05	811	63	11	CID000000892
Drug	triparanol	FDFT1 DHCR7 SHH IHH	1.52e-05	54	63	4	CID000006536
Drug	C2-ceramide	ARHGAP1 PLPP1 PLPP2 PIK3CA MAPK6 MAP3K1 CRTAP	1.66e-05	294	63	7	CID000002505
Drug	NVP & EFV	FLT4 PIK3CA DHCR7 SHH IHH	2.14e-05	121	63	5	CID000492400
Drug	7 cholesterol	FDFT1 DHCR7 SHH IHH	2.99e-05	64	63	4	CID000000420
Drug	AC1L19AY	PLPP1 FDFT1 INPP5J	3.92e-05	24	63	3	CID000000468
Disease	autism spectrum disorder (is_marker_for)	SHH IHH	8.48e-05	7	60	2	DOID:0060041 (is_marker_for)
Disease	Polydactyly	TRIM32 PIK3CA SHH CPLANE1	9.65e-05	117	60	4	C0152427
Disease	Gonadal Dysgenesis, 46,XY	ZFPM2 MAP3K1	1.13e-04	8	60	2	C0018054
Disease	primary bacterial infectious disease (implicated_via_orthology)	SHH IHH	1.45e-04	9	60	2	DOID:0050338 (implicated_via_orthology)
Disease	46,XY partial gonadal dysgenesis	ZFPM2 MAP3K1	2.21e-04	11	60	2	C4510744
Disease	Malformations of Cortical Development	PIK3CA WDR62	3.64e-04	14	60	2	C1955869
Disease	Lung cancer	ERCC6 PIK3CA	3.64e-04	14	60	2	cv:C0242379
Disease	LUNG CANCER	ERCC6 PIK3CA	3.64e-04	14	60	2	211980
Disease	Cortical Dysplasia	PIK3CA WDR62	3.64e-04	14	60	2	C0431380
Disease	rostral middle frontal gyrus volume measurement	MAPK6 AGBL1	3.64e-04	14	60	2	EFO_0010328
Disease	Neoplasm of lung	ERCC6 PIK3CA	3.64e-04	14	60	2	cv:C0024121
Disease	stomach cancer (is_implicated_in)	ERCC6 PIK3CA MAP3K1	4.31e-04	72	60	3	DOID:10534 (is_implicated_in)
Disease	Tetralogy of Fallot	FLT4 ZFPM2	4.79e-04	16	60	2	C0039685
Disease	hypothyroidism (biomarker_via_orthology)	RELN SRD5A1 SHH	5.87e-04	80	60	3	DOID:1459 (biomarker_via_orthology)
Disease	temporal lobe epilepsy (is_marker_for)	RELN SHH	7.55e-04	20	60	2	DOID:3328 (is_marker_for)
Disease	Congenital diaphragmatic hernia	WNT11 ZFPM2	8.33e-04	21	60	2	C0235833
Disease	Sarcoma	FLT4 PIK3CA	8.33e-04	21	60	2	C1261473
Disease	Nephritis, Tubulointerstitial	DHCR7 SLC3A1	8.33e-04	21	60	2	C0041349
Disease	colorectal carcinoma (is_implicated_in)	ERCC6 PIK3CA	9.15e-04	22	60	2	DOID:0080199 (is_implicated_in)
Disease	Liver Cirrhosis, Experimental	ATRN FRY SERPINA4 PLPP2 SRD5A1 NOCT CRTAP	9.60e-04	774	60	7	C0023893
Disease	Carcinoma of lung	ERCC6 PIK3CA	1.00e-03	23	60	2	C0684249
Disease	Nephritis, Interstitial	DHCR7 SLC3A1	1.09e-03	24	60	2	C0027707
Disease	L-arginine measurement	VIL1 PRMT7	1.38e-03	27	60	2	EFO_0006524
Disease	Malignant neoplasm of breast	IFNB1 CATSPERE ERCC6 PIK3CA MTMR3 ITGA9 KAT6B MAP3K1	1.43e-03	1074	60	8	C0006142
Disease	Hyperplasia	PIK3CA MAPK6	1.49e-03	28	60	2	C0020507
Disease	susceptibility to rheumatic fever measurement	RELN RYR3	1.49e-03	28	60	2	EFO_0008416
Disease	Neoplasm of uncertain or unknown behavior of ovary	ERCC6 PIK3CA	1.59e-03	29	60	2	C0496920
Disease	Ovarian Carcinoma	ERCC6 PIK3CA	1.71e-03	30	60	2	C0029925
Disease	Severe Congenital Microcephaly	ERCC6 WDR62	1.82e-03	31	60	2	C3853041

Protein segments in the cluster

Peptide	Gene	Start	Entry
RIESYWTYEVCHGKH	ERLEC1	116	Q96DZ1
WTYEVCHGKHIRQYH	ERLEC1	121	Q96DZ1
YCGVYLHTVRWHQKD	ARSH	426	Q5FYA8
ICYSFLDLKYHWIHN	CEACAM18	256	A8MTB9
ESSHTCFLWYYRVRH	CATSPERE	96	Q5SY80
YLKTIDICHDHFGWY	DHCR7	291	Q9UBM7
SRYDWHYVILDEGHK	ERCC6	636	Q03468
WIRTGHEICYYKNHY	AGBL1	681	Q96MI9
EHLADYLEAYWKATH	CACNB2	451	Q08289
VLACHYDSKYFSHWN	QPCT	136	Q16769
LFCKYIYHVLWHSEF	PARP9	386	Q8IXQ6
WKSVILEYLYHHHER	KAT6B	906	Q8WYB5
HFATECSWDHLYVYD	ATRN	176	O75882
DNYLVHKKHYCSSRW	ZFPM2	561	Q8WW38
HVTSEQEWDKYCHYV	FDFT1	161	P37268
VESPYRCHWCKYRHV	PLXNA4	666	Q9HCM2
ETHSHIYNWERYHDC	MAPK6	346	Q16659
NHFLYSSWSDYIHIC	DCAF11	231	Q8TEB1
GYTRVSDYKHHWSDV	PLPP2	211	O43688
RKDHDSYWQSCYAEL	PLEKHM3	221	Q6ZWE6
KQERHDWDYCEHRDY	NDUFB7	81	P17568
QEKDFLWSHRHYCVT	PIK3CA	546	P42336
YYWHRSLEKIHQCEN	IL13RA1	161	P78552
TWKLLEHYSYLSYHE	RELN	806	P78509
ACAHRWKNIYYEADH	ITGA9	141	Q13797
HWRVSYSSCKYSHLI	B3GALT2	366	O43825
TCVRHWRLWKHYSDY	AWAT2	71	Q6E213
HSYFSSYQDHAKWCI	DNASE2B	296	Q8WZ79
HQCLSIHYWDIRYKQ	CPLANE1	641	Q9H799
SALYLVAHHDDYCVW	PRMT7	331	Q9NVM4
VAHHDDYCVWYSLQR	PRMT7	336	Q9NVM4
SAYRHALDKYSGEHW	CRTAP	46	O75718
CYWEIHSFYLHALRI	ATG9A	156	Q7Z3C6
LHYLKAKEYSHCAWT	IFNB1	151	P01574
LAAHSIATTLKYWYH	MDH1B	376	Q5I0G3
HDSHGDAWKYYARKS	GCNA	606	Q96QF7
LYKTHSYTRDCATWV	FRY	2191	Q5TBA9
HALRKTTYHWQELSY	METTL17	136	Q9H7H0
ECRHTLDYIWYSKHA	NOCT	371	Q9UK39
DWVYYESKAHVHCSV	IHH	176	Q14623
YACDSAFWLASRKHH	MTMR3	1126	Q13615
CRSKWRSHDFYSHEL	MAP3K1	491	Q13233
CHHRCDWRHYVGKEY	TRMT13	336	Q9NUP7
WDHCIKIYSYHLRRY	TRIM32	636	Q13049
DWVYYESKAHIHCSV	SHH	171	Q15465
EHHWYLHDRYLPCSV	SERPINA4	251	P29622
IYVGLSRVSDYKHHW	PLPP1	211	O14494
THLKWDDPYYDIARH	ARHGAP1	56	Q07960
GKYTDYYIWHDCTHE	SLC3A1	231	Q07837
YYIWHDCTHENGKTI	SLC3A1	236	Q07837
LIKAERYYAWREEHH	ANKDD1B	386	A6NHY2
RHCKDYVAYVWAKHE	INPP5J	781	Q15735
TCAYTTGHWDNYKRH	ZNF513	476	Q8N8E2
IHKTASSLSYDIHYW	VIL1	51	P09327
HRKYARWKATYIHNC	VTA1	141	Q9NP79
YIVTKYAEHSHDKWA	RYR3	2616	Q15413
LSCQADSYKYEHLRW	FLT4	576	P35916
ADHQYYLSLWESCRK	TMEM47	46	Q9BQJ4
WHSYIDYEICIHTNS	SNX10	26	Q9Y5X0
HQWLSCVYKDHSIYI	WDR62	371	O43379
YTDRVVERCHCKYHW	WNT11	321	O96014
FCFLSGRAKEHHEWY	SRD5A1	226	P18405
ECGYVTKWKHYLRVH	ZNF142	461	P52746
YYSWERCSKHHLNFL	ZNF674	146	Q2M3X9
THYYDKRWSCELFLL	TMEM39B	311	Q9GZU3
YGCWDHYYESDTLLH	NADSYN1	51	Q6IA69