Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	steroid 11-beta-monooxygenase activity	CYP11B1 CYP11B2	6.06e-05	2	156	2	GO:0004507
GeneOntologyMolecularFunction	corticosterone 18-monooxygenase activity	CYP11B1 CYP11B2	6.06e-05	2	156	2	GO:0047783
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-kinase activity	PIK3R3 PIK3CB PIK3CD	7.37e-05	11	156	3	GO:0016303
GeneOntologyMolecularFunction	pyrophosphatase activity	KRAS ABCC3 RAN NUDT7 PMS2 NRAS KIF1A INO80 OPA1 HRAS RAB39B HSPA5 DDX4 AQR MX2 AGAP1 AGAP3	3.10e-04	839	156	17	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	KRAS ABCC3 RAN NUDT7 PMS2 NRAS KIF1A INO80 OPA1 HRAS RAB39B HSPA5 DDX4 AQR MX2 AGAP1 AGAP3	3.14e-04	840	156	17	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	KRAS ABCC3 RAN NUDT7 PMS2 NRAS KIF1A INO80 OPA1 HRAS RAB39B HSPA5 DDX4 AQR MX2 AGAP1 AGAP3	3.14e-04	840	156	17	GO:0016818
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	KRAS ABCC3 RAN PMS2 NRAS KIF1A INO80 OPA1 HRAS RAB39B HSPA5 DDX4 AQR MX2 AGAP1 AGAP3	3.82e-04	775	156	16	GO:0017111
GeneOntologyBiologicalProcess	cell morphogenesis	CDH26 KIF1A CDHR1 LAMA3 SRGAP2 PTCH1 GRHL2 ITGB1 CIT OPA1 WDPCP MAP3K1 DIP2A FAT1 PTPRJ VPS13A DOCK7 UGT8 MAEL PRKDC RERE TBR1 TNR AGRN VASP EPHA8	1.03e-06	1194	156	26	GO:0000902
GeneOntologyBiologicalProcess	tissue morphogenesis	KRAS LIAS FAT4 INTU PTCH1 GRHL2 ITGB1 OPA1 WDPCP MAP3K1 EOMES TGFBR3 FAT1 PIK3CD CC2D2A CPLANE1 TACSTD2 VASP	1.55e-05	750	156	18	GO:0048729
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	KRAS LIAS FAT4 INTU PTCH1 GRHL2 ITGB1 OPA1 WDPCP MAP3K1 FAT1 PIK3CD CC2D2A CPLANE1 TACSTD2 VASP	1.94e-05	619	156	16	GO:0002009
GeneOntologyBiologicalProcess	central nervous system development	KRAS RAN FAT4 INTU KIF1A SRGAP2 PTCH1 GRHL2 ITGB1 EOMES LSR PTPRJ ATXN1 VPS13A DOCK7 UGT8 PRKDC RERE TBR1 HERC1 CPLANE1 TNR HSPA5	3.47e-05	1197	156	23	GO:0007417
GeneOntologyBiologicalProcess	mitotic sister chromatid segregation	RAN ZWILCH DCTN2 INO80 CIT NCAPG2 NCAPG TPX2 BUB3	3.50e-05	212	156	9	GO:0000070
GeneOntologyBiologicalProcess	smoothened signaling pathway	INTU FBXL17 POR KCTD21 PTCH1 WDPCP CIBAR1 CC2D2A	5.94e-05	176	156	8	GO:0007224
GeneOntologyBiologicalProcess	brain development	KRAS RAN FAT4 KIF1A SRGAP2 PTCH1 GRHL2 ITGB1 EOMES ATXN1 DOCK7 PRKDC RERE TBR1 HERC1 CPLANE1 TNR HSPA5	9.05e-05	859	156	18	GO:0007420
GeneOntologyBiologicalProcess	neuron projection development	FAT4 KIF1A INPPL1 RAP1GAP2 LAMA3 SRGAP2 PTCH1 ITGB1 CIT OPA1 DIP2A AP5Z1 VPS13A DOCK7 UGT8 RERE TBR1 HERC1 TNR AGRN HSPA5 VASP EPHA8	1.02e-04	1285	156	23	GO:0031175
GeneOntologyBiologicalProcess	neuron development	FAT4 KIF1A CDHR1 INPPL1 RAP1GAP2 LAMA3 SRGAP2 PTCH1 ITGB1 CIT OPA1 WDPCP DIP2A AP5Z1 VPS13A DOCK7 UGT8 RERE TBR1 HERC1 TNR AGRN HSPA5 VASP EPHA8	1.03e-04	1463	156	25	GO:0048666
GeneOntologyBiologicalProcess	neuron projection morphogenesis	KIF1A LAMA3 SRGAP2 PTCH1 ITGB1 CIT OPA1 DIP2A VPS13A DOCK7 UGT8 RERE TBR1 TNR AGRN VASP EPHA8	1.25e-04	802	156	17	GO:0048812
GeneOntologyBiologicalProcess	sister chromatid segregation	RAN ZWILCH DCTN2 INO80 CIT NCAPG2 NCAPG TPX2 BUB3	1.40e-04	254	156	9	GO:0000819
GeneOntologyBiologicalProcess	regulation of smoothened signaling pathway	INTU FBXL17 POR KCTD21 PTCH1 CIBAR1	1.48e-04	105	156	6	GO:0008589
GeneOntologyBiologicalProcess	neural tube development	LIAS INTU PTCH1 GRHL2 OPA1 WDPCP CC2D2A VASP	1.55e-04	202	156	8	GO:0021915
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	KIF1A LAMA3 SRGAP2 PTCH1 ITGB1 CIT OPA1 DIP2A VPS13A DOCK7 UGT8 RERE TBR1 TNR AGRN VASP EPHA8	1.60e-04	819	156	17	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	KIF1A LAMA3 SRGAP2 PTCH1 ITGB1 CIT OPA1 DIP2A VPS13A DOCK7 UGT8 RERE TBR1 TNR AGRN VASP EPHA8	1.77e-04	826	156	17	GO:0048858
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	KIF1A CDHR1 LAMA3 PTCH1 ITGB1 CIT OPA1 WDPCP DIP2A DOCK7 RERE TBR1 TNR AGRN VASP EPHA8	1.80e-04	748	156	16	GO:0048667
GeneOntologyBiologicalProcess	head development	KRAS RAN FAT4 KIF1A SRGAP2 PTCH1 GRHL2 ITGB1 EOMES ATXN1 DOCK7 PRKDC RERE TBR1 HERC1 CPLANE1 TNR HSPA5	2.09e-04	919	156	18	GO:0060322
GeneOntologyBiologicalProcess	neural tube closure	LIAS PTCH1 GRHL2 OPA1 CC2D2A VASP	2.21e-04	113	156	6	GO:0001843
GeneOntologyBiologicalProcess	morphogenesis of a polarized epithelium	FAT4 INTU WDPCP FAT1 CPLANE1	2.30e-04	73	156	5	GO:0001738
GeneOntologyBiologicalProcess	tube closure	LIAS PTCH1 GRHL2 OPA1 CC2D2A VASP	2.31e-04	114	156	6	GO:0060606
GeneOntologyBiologicalProcess	primary neural tube formation	LIAS PTCH1 GRHL2 OPA1 CC2D2A VASP	3.05e-04	120	156	6	GO:0014020
GeneOntologyBiologicalProcess	positive regulation of Rac protein signal transduction	KRAS PIK3CB AGRN	3.19e-04	18	156	3	GO:0035022
GeneOntologyBiologicalProcess	regulation of blood volume by renal aldosterone	CYP11B1 CYP11B2	3.38e-04	4	156	2	GO:0002017
GeneOntologyBiologicalProcess	establishment of planar polarity	FAT4 INTU WDPCP CPLANE1	3.38e-04	44	156	4	GO:0001736
GeneOntologyBiologicalProcess	epithelial tube formation	LIAS PTCH1 GRHL2 OPA1 PIK3CD CC2D2A VASP	3.53e-04	173	156	7	GO:0072175
GeneOntologyBiologicalProcess	establishment of tissue polarity	FAT4 INTU WDPCP CPLANE1	3.69e-04	45	156	4	GO:0007164
GeneOntologyBiologicalProcess	nuclear chromosome segregation	RAN ZWILCH DCTN2 INO80 CIT NCAPG2 NCAPG TPX2 MAEL BUB3	3.91e-04	356	156	10	GO:0098813
GeneOntologyBiologicalProcess	cell junction assembly	CDH26 FRMPD2 LAMA3 SRGAP2 ADGRE2 GRHL2 ITGB1 WDPCP LSR PTPRJ DOCK7 UGT8 AGRN	3.99e-04	569	156	13	GO:0034329
GeneOntologyBiologicalProcess	organelle fission	RAN ZWILCH DCTN2 INO80 CIT NCAPG2 OPA1 STAT2 NCAPG TPX2 MAEL BUB3 DDX4	4.12e-04	571	156	13	GO:0048285
GeneOntologyBiologicalProcess	cell junction organization	CDH26 KIF1A FRMPD2 LAMA3 SRGAP2 ADGRE2 GRHL2 ITGB1 OPA1 WDPCP DIP2A LSR PTPRJ DOCK7 UGT8 RAB39B TNR AGRN	4.21e-04	974	156	18	GO:0034330
GeneOntologyBiologicalProcess	ruffle assembly	INPPL1 WDPCP HRAS TACSTD2	4.36e-04	47	156	4	GO:0097178
GeneOntologyBiologicalProcess	neural tube formation	LIAS PTCH1 GRHL2 OPA1 CC2D2A VASP	5.50e-04	134	156	6	GO:0001841
GeneOntologyBiologicalProcess	positive regulation of neutrophil apoptotic process	PIK3CB PIK3CD	5.60e-04	5	156	2	GO:0033031
GeneOntologyBiologicalProcess	tube formation	LIAS PTCH1 GRHL2 OPA1 PIK3CD CC2D2A VASP	5.63e-04	187	156	7	GO:0035148
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	FAT4 CDH26 CDHR1 ITGB1 FAT1 PIK3CB PCDH1	5.63e-04	187	156	7	GO:0007156
GeneOntologyBiologicalProcess	piRNA processing	MAEL GPAT2 DDX4	5.88e-04	22	156	3	GO:0034587
GeneOntologyBiologicalProcess	phosphatidylinositol-3-phosphate biosynthetic process	PIK3R3 PIK3CB PIK3CD	5.88e-04	22	156	3	GO:0036092
GeneOntologyCellularComponent	phosphatidylinositol 3-kinase complex, class I	PIK3R3 PIK3CB PIK3CD	3.51e-05	9	159	3	GO:0097651
GeneOntologyCellularComponent	phosphatidylinositol 3-kinase complex, class IA	PIK3R3 PIK3CB PIK3CD	3.51e-05	9	159	3	GO:0005943
GeneOntologyCellularComponent	phosphatidylinositol 3-kinase complex	PIK3R3 CISH PIK3CB PIK3CD	6.60e-05	29	159	4	GO:0005942
HumanPheno	Linear nevus sebaceous	KRAS NRAS HRAS	2.71e-06	3	72	3	HP:0010817
HumanPheno	Abnormality of globe size	KRAS INTU ADAMTSL1 NRAS PTCH1 NCAPG2 FREM1 HIRA ALKBH8 HRAS DOCK7 CPSF1 CC2D2A RERE TBR1 BUB3	6.35e-06	319	72	16	HP:0100887
HumanPheno	Benign neoplasm of the central nervous system	KRAS FAT4 PMS2 NRAS POLD1 PTCH1 WDPCP CPLANE1 SDHA	1.38e-05	105	72	9	HP:0100835
HumanPheno	Renal neoplasm	KRAS PMS2 NRAS POLD1 PTCH1 MAP3K1 PTPRJ HRAS BUB3 SDHA	2.09e-05	139	72	10	HP:0009726
HumanPheno	Nevus sebaceous	KRAS NRAS HRAS	2.65e-05	5	72	3	HP:0010815
HumanPheno	Urinary tract neoplasm	KRAS PMS2 NRAS POLD1 PTCH1 MAP3K1 PTPRJ HRAS BUB3 SDHA	2.85e-05	144	72	10	HP:0010786
HumanPheno	Megalencephaly	KRAS NRAS PTCH1 HRAS RAB39B HERC1	2.98e-05	44	72	6	HP:0001355
HumanPheno	Caesarian section	CYP11B1 CYP11B2 POR OPA1	4.45e-05	15	72	4	HP:0011410
HumanPheno	Neoplasm of the stomach	KRAS PMS2 NRAS POLD1 PTCH1 PTPRJ BUB3 SDHA	6.11e-05	98	72	8	HP:0006753
HumanPheno	Neoplasm of the genitourinary tract	KRAS PMS2 NRAS CYP11B1 POLD1 PTCH1 ADA2 MAP3K1 PTPRJ HRAS BUB3 SDHA	6.83e-05	228	72	12	HP:0007379
HumanPheno	Lymphoproliferative disorder	KRAS NRAS ADA2 IL2RG	7.60e-05	17	72	4	HP:0005523
HumanPheno	Cranial asymmetry	KRAS NRAS PTCH1 HRAS	7.60e-05	17	72	4	HP:0000267
HumanPheno	Neoplasm of the nervous system	KRAS FAT4 PMS2 NRAS POLD1 PTCH1 WDPCP HRAS RERE CPLANE1 SDHA	7.61e-05	195	72	11	HP:0004375
HumanPheno	Basal cell carcinoma	KRAS PMS2 NRAS POLD1 PTCH1 HRAS	1.46e-04	58	72	6	HP:0002671
HumanPheno	Neoplasm of the central nervous system	KRAS FAT4 PMS2 NRAS POLD1 PTCH1 WDPCP RERE CPLANE1 SDHA	1.72e-04	178	72	10	HP:0100006
HumanPheno	Neoplasm of the large intestine	KRAS PMS2 NRAS POLD1 ADA2 PTPRJ BUB3 SDHA	1.79e-04	114	72	8	HP:0100834
HumanPheno	Neoplasm of the oral cavity	KRAS INTU PMS2 PTCH1 WDPCP CPLANE1	2.13e-04	62	72	6	HP:0100649
HumanPheno	Elevated serum 11-deoxycortisol	CYP11B1 CYP11B2 POR	2.14e-04	9	72	3	HP:0025436
HumanPheno	Genital neoplasm	KRAS PMS2 NRAS CYP11B1 POLD1 PTCH1 MAP3K1 PTPRJ BUB3	2.29e-04	150	72	9	HP:0010787
MousePheno	abnormal head morphology	KRAS LIAS INPPL1 LAMA3 MAGEE2 QRICH1 PTCH1 GRHL2 ITGB1 VWDE REXO1 WDPCP FREM1 HIRA TGFBR3 DIP2A PPP2R1B FAT1 PTPRJ AP5Z1 HRAS CC2D2A RERE CPLANE1 GPR176 AGAP1 CA6	7.48e-06	1120	135	27	MP:0000432
MousePheno	abnormal brain size	LIAS ANKFY1 CYP11B1 CYP11B2 MAGEE2 GRHL2 ITGB1 CIT ATXN1 RERE RAB39B TBR1 CPLANE1 HSPA5	1.58e-05	375	135	14	MP:0000771
MousePheno	pulmonary valve atresia	WDPCP CC2D2A CPLANE1	1.72e-05	6	135	3	MP:0006130
MousePheno	uterus adenomyosis	KRAS CYP11B1 CYP11B2	1.72e-05	6	135	3	MP:0009221
MousePheno	increased circulating angiotensin II level	CYP11B1 CYP11B2 HRAS	4.76e-05	8	135	3	MP:0031232
MousePheno	increased angiotensin II level	CYP11B1 CYP11B2 HRAS	4.76e-05	8	135	3	MP:0031229
MousePheno	abnormal embryonic neuroepithelium morphology	KRAS INTU GRHL2 ITGB1 WDPCP HIRA CC2D2A	6.95e-05	105	135	7	MP:0004261
MousePheno	abnormal urine progesterone level	CYP11B1 CYP11B2	9.26e-05	2	135	2	MP:0011545
MousePheno	abnormal urine deoxycorticosterone level	CYP11B1 CYP11B2	9.26e-05	2	135	2	MP:0011552
MousePheno	decreased urine corticosterone level	CYP11B1 CYP11B2	9.26e-05	2	135	2	MP:0011550
MousePheno	increased urine deoxycorticosterone level	CYP11B1 CYP11B2	9.26e-05	2	135	2	MP:0011553
MousePheno	increased urine progesterone level	CYP11B1 CYP11B2	9.26e-05	2	135	2	MP:0011546
MousePheno	abnormal circulating angiotensin II level	CYP11B1 CYP11B2 HRAS	1.82e-04	12	135	3	MP:0031230
MousePheno	abnormal angiotensin II level	CYP11B1 CYP11B2 HRAS	1.82e-04	12	135	3	MP:0031227
MousePheno	abnormal neural tube morphology	KRAS LIAS FAT4 INTU POR PTCH1 GRHL2 ITGB1 OPA1 WDPCP HIRA PRRC2C CC2D2A RERE TBR1 SEC23A	1.84e-04	591	135	16	MP:0002151
MousePheno	abnormal metencephalon morphology	ANKFY1 MAGEE2 CMYA5 PTCH1 CIT OPA1 ATXN1 AP5Z1 UGT8 RERE HERC1 CPLANE1 HSPA5	2.13e-04	420	135	13	MP:0000847
MousePheno	abnormal hindbrain morphology	ANKFY1 MAGEE2 CMYA5 PTCH1 ITGB1 CIT OPA1 ATXN1 AP5Z1 UGT8 RERE HERC1 CPLANE1 HSPA5	2.49e-04	485	135	14	MP:0000841
MousePheno	polydactyly	INTU PTCH1 WDPCP FREM1 CIBAR1 CC2D2A CPLANE1	2.52e-04	129	135	7	MP:0000562
MousePheno	abnormal neural tube closure	LIAS POR PTCH1 GRHL2 ITGB1 OPA1 HIRA PRRC2C CC2D2A RERE TBR1 SEC23A	2.99e-04	378	135	12	MP:0003720
MousePheno	abnormal heart ventricle outflow tract morphology	KRAS WDPCP TULP4 HRAS CC2D2A CPLANE1	3.30e-04	96	135	6	MP:0010224
MousePheno	abnormal semilunar valve morphology	KRAS WDPCP TULP4 HRAS CC2D2A CPLANE1	3.49e-04	97	135	6	MP:0002746
MousePheno	abnormal cerebellum morphology	ANKFY1 CMYA5 PTCH1 CIT OPA1 ATXN1 AP5Z1 UGT8 RERE HERC1 CPLANE1 HSPA5	3.87e-04	389	135	12	MP:0000849
MousePheno	exencephaly	LIAS INTU POR PTCH1 GRHL2 ITGB1 OPA1 CC2D2A SEC23A	3.92e-04	230	135	9	MP:0000914
Domain	EGF-like_CS	FAT4 ADAM20 LAMA3 ADGRE2 ITGB1 VWDE MFGE8 FAT1 TNR AGRN EPHA8	1.33e-05	261	157	11	IPR013032
Domain	EGF_1	FAT4 ADAM20 LAMA3 ADGRE2 ITGB1 VWDE MFGE8 FAT1 TNR AGRN	6.10e-05	255	157	10	PS00022
Domain	T-box_assoc	EOMES TBR1	7.02e-05	2	157	2	PF16176
Domain	T-box_assoc	EOMES TBR1	7.02e-05	2	157	2	IPR032385
Domain	Cyt_P450_mitochondrial	CYP11B1 CYP11B2	7.02e-05	2	157	2	IPR002399
Domain	EGF_2	FAT4 ADAM20 LAMA3 ADGRE2 VWDE MFGE8 FAT1 TNR AGRN EPHA8	8.40e-05	265	157	10	PS01186
Domain	Laminin_G	FAT4 COL12A1 LAMA3 FAT1 AGRN	1.26e-04	58	157	5	IPR001791
Domain	Ras	KRAS RAN NRAS HRAS RAB39B AGAP1 AGAP3	1.53e-04	136	157	7	PF00071
Domain	RAS	KRAS NRAS HRAS AGAP3	2.05e-04	35	157	4	PS51421
Domain	PI3K_p85B	PIK3CB PIK3CD	2.09e-04	3	157	2	PF02192
Domain	PI3K_p85B	PIK3CB PIK3CD	2.09e-04	3	157	2	SM00143
Domain	SH2	INPPL1 PIK3R3 TEC STAT2 CISH SHE	2.10e-04	101	157	6	PF00017
Domain	PI3/4_kinase_CS	PIK3CB PIK3CD PRKDC	2.46e-04	15	157	3	IPR018936
Domain	Small_GTPase_Ras	KRAS NRAS HRAS AGAP3	2.56e-04	37	157	4	IPR020849
Domain	EGF-like_dom	FAT4 ADAM20 LAMA3 ADGRE2 VWDE MFGE8 FAT1 TNR AGRN	2.63e-04	249	157	9	IPR000742
Domain	P-loop_NTPase	KRAS ABCC3 ATP6V1B1 RAN NRAS KIF1A DAPK1 INO80 OPA1 NDST3 SBNO1 HRAS RAB39B DDX4 AQR MX2 AGAP1 AGAP3	2.83e-04	848	157	18	IPR027417
Domain	LAM_G_DOMAIN	FAT4 LAMA3 FAT1 AGRN	2.84e-04	38	157	4	PS50025
Domain	-	PIK3CB PIK3CD PRKDC	3.01e-04	16	157	3	1.10.1070.11
Domain	PI3Kc	PIK3CB PIK3CD PRKDC	3.01e-04	16	157	3	SM00146
Domain	SH2	INPPL1 PIK3R3 TEC STAT2 CISH SHE	3.34e-04	110	157	6	SM00252
Domain	SH2	INPPL1 PIK3R3 TEC STAT2 CISH SHE	3.51e-04	111	157	6	PS50001
Domain	SH2	INPPL1 PIK3R3 TEC STAT2 CISH SHE	3.68e-04	112	157	6	IPR000980
Domain	-	INPPL1 PIK3R3 TEC STAT2 CISH SHE	3.68e-04	112	157	6	3.30.505.10
Domain	Small_GTPase	KRAS RAN NRAS HRAS RAB39B AGAP1 AGAP3	4.13e-04	160	157	7	IPR001806
Domain	PI3K_ABD	PIK3CB PIK3CD	4.17e-04	4	157	2	PS51544
Domain	PI3K_adapt-bd_dom	PIK3CB PIK3CD	4.17e-04	4	157	2	IPR003113
Domain	PI3_PI4_kinase	PIK3CB PIK3CD PRKDC	4.33e-04	18	157	3	PF00454
Domain	PI3_4_KINASE_1	PIK3CB PIK3CD PRKDC	4.33e-04	18	157	3	PS00915
Domain	PI3_4_KINASE_2	PIK3CB PIK3CD PRKDC	4.33e-04	18	157	3	PS00916
Domain	PI3/4_kinase_cat_dom	PIK3CB PIK3CD PRKDC	4.33e-04	18	157	3	IPR000403
Domain	PI3_4_KINASE_3	PIK3CB PIK3CD PRKDC	4.33e-04	18	157	3	PS50290
Domain	Cadherin	FAT4 CDH26 CDHR1 FREM1 FAT1 PCDH1	4.87e-04	118	157	6	IPR002126
Domain	LamG	FAT4 LAMA3 FAT1 AGRN	5.02e-04	44	157	4	SM00282
Domain	ConA-like_dom	FAT4 COL12A1 LAMA3 CMYA5 FAT1 TRIM16L HERC1 AGRN	5.39e-04	219	157	8	IPR013320
Domain	-	KRAS ABCC3 ATP6V1B1 RAN NRAS INO80 OPA1 NDST3 SBNO1 HRAS RAB39B DDX4 AQR MX2 AGAP1 AGAP3	5.58e-04	746	157	16	3.40.50.300
Domain	HEAT	NCAPG2 PPP2R1B NCAPG PRKDC	7.01e-04	48	157	4	PF02985
Domain	EGF	FAT4 LAMA3 ADGRE2 VWDE MFGE8 FAT1 TNR AGRN	8.54e-04	235	157	8	SM00181
Domain	EGF_3	FAT4 ADAM20 ADGRE2 VWDE MFGE8 FAT1 TNR AGRN	8.54e-04	235	157	8	PS50026
Domain	-	FAT4 COL12A1 LAMA3 FAT1 AGRN	1.24e-03	95	157	5	2.60.120.200
Domain	HEAT	NCAPG2 PPP2R1B NCAPG PRKDC	1.43e-03	58	157	4	IPR000357
Domain	PI3K_Ras-bd_dom	PIK3CB PIK3CD	1.43e-03	7	157	2	IPR000341
Domain	PI3K_rbd	PIK3CB PIK3CD	1.43e-03	7	157	2	SM00144
Domain	G_DYNAMIN_1	OPA1 MX2	1.43e-03	7	157	2	PS00410
Domain	PI3K_rbd	PIK3CB PIK3CD	1.43e-03	7	157	2	PF00794
Domain	PI3K_RBD	PIK3CB PIK3CD	1.43e-03	7	157	2	PS51546
Domain	DYNc	OPA1 MX2	1.43e-03	7	157	2	SM00053
Domain	PI3K_C2	PIK3CB PIK3CD	1.90e-03	8	157	2	SM00142
Domain	PI3K_C2_dom	PIK3CB PIK3CD	1.90e-03	8	157	2	IPR002420
Domain	PI3K_C2	PIK3CB PIK3CD	1.90e-03	8	157	2	PF00792
Domain	PI3K_C2	PIK3CB PIK3CD	1.90e-03	8	157	2	PS51547
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY	KRAS NRAS PIK3CB PIK3CD HRAS	9.89e-08	14	126	5	M47390
Pathway	PID_ERBB2_ERBB3_PATHWAY	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS DOCK7	1.12e-07	44	126	7	M175
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY	KRAS NRAS PIK3CB PIK3CD HRAS	1.47e-07	15	126	5	M47389
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY	KRAS NRAS PIK3CB PIK3CD HRAS	1.47e-07	15	126	5	M47475
Pathway	PID_PI3KCI_PATHWAY	KRAS NRAS INPPL1 PIK3R3 PIK3CB PIK3CD HRAS	2.09e-07	48	126	7	M141
Pathway	PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	5.94e-07	35	126	6	M127
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_PI3K_SIGNALING_PATHWAY	KRAS NRAS PIK3CB PIK3CD	7.41e-07	9	126	4	M47391
Pathway	REACTOME_INTERLEUKIN_RECEPTOR_SHC_SIGNALING	INPPL1 PIK3R3 PIK3CB PIK3CD IL2RG	1.23e-06	22	126	5	MM15632
Pathway	PID_ERBB1_INTERNALIZATION_PATHWAY	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	1.57e-06	41	126	6	M214
Pathway	PID_CXCR3_PATHWAY	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	2.10e-06	43	126	6	M222
Pathway	WP_RELATIONSHIP_BETWEEN_INFLAMMATION_COX2_AND_EGFR	KRAS NRAS PIK3CB PIK3CD HRAS	2.42e-06	25	126	5	M39794
Pathway	REACTOME_SIGNALING_BY_ERYTHROPOIETIN	KRAS NRAS PIK3CB PIK3CD HRAS	2.42e-06	25	126	5	M27865
Pathway	REACTOME_SIGNALING_BY_PDGFRA_TRANSMEMBRANE_JUXTAMEMBRANE_AND_KINASE_DOMAIN_MUTANTS	KRAS NRAS PIK3CB HRAS	2.85e-06	12	126	4	M29851
Pathway	REACTOME_INTERLEUKIN_RECEPTOR_SHC_SIGNALING	INPPL1 PIK3R3 PIK3CB PIK3CD IL2RG	3.63e-06	27	126	5	M921
Pathway	REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING	INPPL1 PIK3R3 TEC PIK3CB PIK3CD IL2RG	4.08e-06	48	126	6	M914
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY	KRAS NRAS MAP3K1 HRAS	4.09e-06	13	126	4	M47594
Pathway	WP_NANOPARTICLEMEDIATED_ACTIVATION_OF_RECEPTOR_SIGNALING	KRAS NRAS ITGB1 PIK3CD HRAS	4.39e-06	28	126	5	M39572
Pathway	WP_SYNAPTIC_SIGNALING_ASSOCIATED_WITH_AUTISM_SPECTRUM_DISORDER	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	5.21e-06	50	126	6	M39822
Pathway	WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS	KRAS NRAS TGFBR3 MFGE8 HRAS	5.27e-06	29	126	5	M39516
Pathway	REACTOME_SIGNALING_BY_MET	KRAS NRAS LAMA3 ITGB1 PTPRJ HRAS DOCK7	6.55e-06	79	126	7	M27643
Pathway	KEGG_ENDOMETRIAL_CANCER	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	6.58e-06	52	126	6	M19877
Pathway	REACTOME_ACTIVATION_OF_RAS_IN_B_CELLS	KRAS NRAS HRAS	6.88e-06	5	126	3	M26921
Pathway	KEGG_NON_SMALL_CELL_LUNG_CANCER	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	8.23e-06	54	126	6	M19818
Pathway	WP_PI3KAKTMTOR_SIGNALING_AND_THERAPEUTIC_OPPORTUNITIES_IN_PROSTATE_CANCER	KRAS NRAS PIK3R3 PIK3CB HRAS	8.74e-06	32	126	5	M39445
Pathway	KEGG_ACUTE_MYELOID_LEUKEMIA	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	1.13e-05	57	126	6	M19888
Pathway	REACTOME_ESTROGEN_STIMULATED_SIGNALING_THROUGH_PRKCZ	KRAS NRAS HRAS	1.37e-05	6	126	3	M27951
Pathway	KEGG_MEDICUS_VARIANT_LOSS_OF_RASSF1_TO_RAS_RASSF1_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.37e-05	6	126	3	M47433
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_RAS_UBIQUITINATION_BY_CUL3_COMPLEX	KRAS NRAS HRAS	1.37e-05	6	126	3	M47931
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_SPRED_AND_NF1	KRAS NRAS HRAS	1.37e-05	6	126	3	M47932
Pathway	REACTOME_INTERLEUKIN_2_FAMILY_SIGNALING	INPPL1 PIK3R3 PIK3CB PIK3CD IL2RG	1.38e-05	35	126	5	MM15144
Pathway	WP_MET_IN_TYPE_1_PAPILLARY_RENAL_CELL_CARCINOMA	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	1.38e-05	59	126	6	M39750
Pathway	REACTOME_TIE2_SIGNALING	KRAS NRAS PIK3CB HRAS	1.69e-05	18	126	4	M11932
Pathway	WP_ENDOMETRIAL_CANCER	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	2.03e-05	63	126	6	M39623
Pathway	REACTOME_RAS_SIGNALING_DOWNSTREAM_OF_NF1_LOSS_OF_FUNCTION_VARIANTS	KRAS NRAS HRAS	2.38e-05	7	126	3	M29717
Pathway	REACTOME_SOS_MEDIATED_SIGNALLING	KRAS NRAS HRAS	2.38e-05	7	126	3	M19489
Pathway	WP_KISSPEPTINKISSPEPTIN_RECEPTOR_SYSTEM_IN_THE_OVARY	KRAS NRAS PIK3CB PIK3CD HRAS	2.38e-05	39	126	5	M39905
Pathway	KEGG_GLIOMA	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	2.43e-05	65	126	6	M1835
Pathway	REACTOME_SIGNALING_BY_KIT_IN_DISEASE	KRAS NRAS PIK3R3 HRAS	2.64e-05	20	126	4	M39002
Pathway	REACTOME_SIGNALING_BY_PDGFR_IN_DISEASE	KRAS NRAS PIK3CB HRAS	2.64e-05	20	126	4	M29849
Pathway	REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING	INPPL1 PIK3R3 PIK3CB PIK3CD IL2RG	3.05e-05	41	126	5	MM15162
Pathway	WP_ACUTE_MYELOID_LEUKEMIA	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	3.15e-05	68	126	6	M48322
Pathway	WP_MELANOMA	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	3.15e-05	68	126	6	M39811
Pathway	KEGG_RENAL_CELL_CARCINOMA	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	3.72e-05	70	126	6	M13266
Pathway	REACTOME_ACTIVATED_NTRK3_SIGNALS_THROUGH_RAS	KRAS NRAS HRAS	3.78e-05	8	126	3	M27919
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_RASGAP	KRAS NRAS HRAS	3.78e-05	8	126	3	M47935
Pathway	REACTOME_SIGNALING_BY_SCF_KIT	KRAS NRAS PIK3R3 TEC HRAS	3.86e-05	43	126	5	M508
Pathway	KEGG_MELANOMA	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	4.03e-05	71	126	6	M15798
Pathway	PID_ERBB1_DOWNSTREAM_PATHWAY	KRAS NRAS PIK3R3 MAP3K1 PIK3CB PIK3CD HRAS	4.25e-05	105	126	7	M164
Pathway	REACTOME_INTERLEUKIN_2_FAMILY_SIGNALING	INPPL1 PIK3R3 PIK3CB PIK3CD IL2RG	4.33e-05	44	126	5	M1012
Pathway	WP_NONSMALL_CELL_LUNG_CANCER	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	4.36e-05	72	126	6	M39738
Pathway	KEGG_CHRONIC_MYELOID_LEUKEMIA	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	4.72e-05	73	126	6	M321
Pathway	WP_EGFR1_SIGNALING_PATHWAY	KRAS NRAS INPPL1 PIK3R3 STAT2 MAP3K1 PIK3CB PIK3CD HRAS	4.75e-05	188	126	9	MM15828
Pathway	KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	KRAS NRAS PIK3R3 TEC PIK3CB PIK3CD HRAS	5.09e-05	108	126	7	M9904
Pathway	KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	5.50e-05	75	126	6	M5436
Pathway	REACTOME_EGFR_TRANSACTIVATION_BY_GASTRIN	KRAS NRAS HRAS	5.63e-05	9	126	3	M27156
Pathway	REACTOME_SHC_RELATED_EVENTS_TRIGGERED_BY_IGF1R	KRAS NRAS HRAS	5.63e-05	9	126	3	M27173
Pathway	REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_RAS	KRAS NRAS HRAS	5.63e-05	9	126	3	M27904
Pathway	WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT	KRAS NRAS PIK3R3 MAP3K1 PIK3CB PIK3CD HRAS	5.72e-05	110	126	7	M39492
Pathway	KEGG_VEGF_SIGNALING_PATHWAY	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	5.93e-05	76	126	6	M1749
Pathway	WP_HEPATITIS_B_INFECTION	KRAS NRAS PIK3R3 STAT2 MAP3K1 PIK3CB PIK3CD HRAS	6.22e-05	151	126	8	M39801
Pathway	KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	7.38e-05	79	126	6	M11816
Pathway	WP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	1.04e-04	84	126	6	M39839
Pathway	WP_MAPK_CASCADE	KRAS NRAS MAP3K1 HRAS	1.06e-04	28	126	4	MM15976
Pathway	PID_TRAIL_PATHWAY	PIK3R3 MAP3K1 PIK3CB PIK3CD	1.06e-04	28	126	4	M79
Pathway	REACTOME_SIGNALING_BY_FGFR4_IN_DISEASE	KRAS NRAS HRAS	1.09e-04	11	126	3	M27535
Pathway	KEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.09e-04	11	126	3	M47370
Pathway	KEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.09e-04	11	126	3	M47371
Pathway	REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_FRS2_AND_FRS3	KRAS NRAS HRAS	1.09e-04	11	126	3	M27911
Pathway	REACTOME_MET_ACTIVATES_RAS_SIGNALING	KRAS NRAS HRAS	1.09e-04	11	126	3	M27740
Pathway	REACTOME_CONSTITUTIVE_SIGNALING_BY_OVEREXPRESSED_ERBB2	KRAS NRAS HRAS	1.09e-04	11	126	3	M29814
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RALGDS_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.09e-04	11	126	3	M47436
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RASSF1_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.09e-04	11	126	3	M47432
Pathway	REACTOME_DAP12_SIGNALING	KRAS NRAS PIK3CB HRAS	1.22e-04	29	126	4	M27171
Pathway	REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION	KRAS NRAS PIK3CB HRAS	1.22e-04	29	126	4	M779
Pathway	KEGG_ERBB_SIGNALING_PATHWAY	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	1.26e-04	87	126	6	M12467
Pathway	PID_IL2_1PATHWAY	KRAS NRAS CISH HRAS IL2RG	1.28e-04	55	126	5	M122
Pathway	KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	KRAS NRAS PIK3R3 MAP3K1 PIK3CB PIK3CD HRAS	1.35e-04	126	126	7	M16763
Pathway	REACTOME_ADAPTIVE_IMMUNE_SYSTEM	KRAS BTBD6 NRAS DCTN2 PIK3R3 RAP1GAP2 ITGB1 FBXL4 UBE4A PPP2R1B PTPRJ PIK3CB PIK3CD HRAS HERC1 HSPA5 VASP SEC23A CD200	1.36e-04	828	126	19	M1058
Pathway	KEGG_PROSTATE_CANCER	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	1.43e-04	89	126	6	M13191
Pathway	KEGG_MEDICUS_REFERENCE_GF_RTK_RAS_PI3K_SIGNALING_PATHWAY	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	1.43e-04	89	126	6	M47963
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.45e-04	12	126	3	M47369
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.45e-04	12	126	3	M47815
Pathway	WP_RALA_DOWNSTREAM_REGULATED_GENES	KRAS NRAS HRAS	1.45e-04	12	126	3	M39408
Pathway	PID_PDGFRB_PATHWAY	KRAS NRAS PIK3R3 PTPRJ PIK3CB PIK3CD HRAS	1.56e-04	129	126	7	M186
Pathway	REACTOME_SIGNALING_BY_CSF1_M_CSF_IN_MYELOID_CELLS	KRAS INPPL1 PIK3CB PIK3CD	1.59e-04	31	126	4	M46423
Pathway	WP_ERBB_SIGNALING	KRAS NRAS PIK3R3 PIK3CB PIK3CD HRAS	1.72e-04	92	126	6	M39715
Pathway	REACTOME_P38MAPK_EVENTS	KRAS NRAS HRAS	1.87e-04	13	126	3	M1441
Pathway	WP_MAPK_CASCADE	KRAS NRAS MAP3K1 HRAS	2.04e-04	33	126	4	M39594
Pathway	REACTOME_ADAPTIVE_IMMUNE_SYSTEM	KRAS BTBD6 DCTN2 PIK3R3 RAP1GAP2 ITGB1 FBXL4 UBE4A PPP2R1B PTPRJ PIK3CB PIK3CD HRAS HERC1 HSPA5 SEC23A CD200	2.22e-04	719	126	17	MM14540
Pathway	WP_PI3KAKT_SIGNALING	KRAS NRAS PIK3R3 LAMA3 ITGB1 PPP2R1B PIK3CB PIK3CD HRAS TNR IL2RG	2.29e-04	339	126	11	M39736
Pathway	REACTOME_RAF_ACTIVATION	KRAS NRAS PPP2R1B HRAS	2.29e-04	34	126	4	M27556
Pathway	WP_JAKSTAT_SIGNALING_IN_THE_REGULATION_OF_BETA_CELLS	KRAS NRAS CISH HRAS	2.29e-04	34	126	4	M48081
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	2.36e-04	14	126	3	M47364
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	2.36e-04	14	126	3	M47365
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	2.36e-04	14	126	3	M47366
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	2.36e-04	14	126	3	M47378
Pathway	REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING	KRAS NRAS HRAS	2.36e-04	14	126	3	M569
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_RAS	KRAS NRAS HRAS	2.36e-04	14	126	3	M27908
Pathway	REACTOME_PTK6_REGULATES_RHO_GTPASES_RAS_GTPASE_AND_MAP_KINASES	KRAS NRAS HRAS	2.36e-04	14	126	3	M27734
Pathway	PID_TCR_RAS_PATHWAY	KRAS NRAS HRAS	2.36e-04	14	126	3	M134
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	KLHL24 SCAMP4 LITAF INPPL1 PIK3R3 PTCH1 SH3D21 MAP3K1 LARP4B GUCY1B2 TULP4 TPX2 ZFR VASP	1.41e-08	430	160	14	35044719
Pubmed	Absence of BRAF, NRAS, KRAS, HRAS mutations, and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto thyroiditis from papillary thyroid carcinomas.	KRAS NRAS PTCH1 HRAS	1.49e-08	7	160	4	20012784
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	RAN ANKFY1 DCTN2 POLD1 INPPL1 LARP4B NCAPG PRRC2C DOCK7 CPSF1 ZFR PRKDC BUB3 HSPA5 NUP160	2.98e-08	534	160	15	35032548
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABCC3 INPPL1 RAP1GAP2 SRGAP2 INO80 PTCH1 CIT REXO1 HIRA DIP2A FAT1 TULP4 PLEKHM2 PIK3CD CPSF1 PRKDC HERC1 LSM10 AGRN SDHA AGAP3	4.23e-08	1105	160	21	35748872
Pubmed	Diagnostic Value of RAS Mutations in Indeterminate Thyroid Nodules.	KRAS NRAS HRAS	9.56e-08	3	160	3	28116986
Pubmed	Mutations of RAS gene family in specimens of bladder cancer.	KRAS NRAS HRAS	9.56e-08	3	160	3	19101897
Pubmed	Promoter hypomethylation as potential confounder of Ras gene overexpression and their clinical significance in subsets of urothelial carcinoma of bladder.	KRAS NRAS HRAS	9.56e-08	3	160	3	33620658
Pubmed	Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.	TGFBR3 PRKDC IL2RG	9.56e-08	3	160	3	23925295
Pubmed	A comprehensive survey of Ras mutations in cancer.	KRAS NRAS HRAS	9.56e-08	3	160	3	22589270
Pubmed	A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation.	KRAS NRAS HRAS	9.56e-08	3	160	3	23496764
Pubmed	Distribution of p21ras during primary palate formation of non-cleft and cleft strains of mice.	KRAS NRAS HRAS	9.56e-08	3	160	3	7776260
Pubmed	Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.	KRAS NRAS HRAS	9.56e-08	3	160	3	25788415
Pubmed	Comparison of liver oncogenic potential among human RAS isoforms.	KRAS NRAS HRAS	9.56e-08	3	160	3	26799184
Pubmed	Ras isoforms: signaling specificities in CD40 pathway.	KRAS NRAS HRAS	9.56e-08	3	160	3	31906952
Pubmed	Partial functional overlap of the three ras genes in mouse embryonic development.	KRAS NRAS HRAS	9.56e-08	3	160	3	18059342
Pubmed	Evidence of a low prevalence of RAS mutations in a large medullary thyroid cancer series.	KRAS NRAS HRAS	9.56e-08	3	160	3	23240926
Pubmed	Absolute Quantification of Endogenous Ras Isoform Abundance.	KRAS NRAS HRAS	9.56e-08	3	160	3	26560143
Pubmed	Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma.	KRAS NRAS HRAS	9.56e-08	3	160	3	17712732
Pubmed	Comprehensive survey of HRAS, KRAS, and NRAS mutations in proliferative thyroid lesions from an ethnically diverse population.	KRAS NRAS HRAS	9.56e-08	3	160	3	24222113
Pubmed	Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis.	KRAS NRAS HRAS	9.56e-08	3	160	3	22945650
Pubmed	Activation of RAS family genes in urothelial carcinoma.	KRAS NRAS HRAS	9.56e-08	3	160	3	19303097
Pubmed	The spatiotemporal regulation of RAS signalling.	KRAS NRAS HRAS	9.56e-08	3	160	3	27911734
Pubmed	Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients.	KRAS NRAS HRAS	9.56e-08	3	160	3	20150643
Pubmed	K-ras is an essential gene in the mouse with partial functional overlap with N-ras.	KRAS NRAS HRAS	9.56e-08	3	160	3	9334313
Pubmed	RAS gene mutations and histomorphometric measurements in oral squamous cell carcinoma.	KRAS NRAS HRAS	9.56e-08	3	160	3	37013448
Pubmed	Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions.	KRAS NRAS HRAS	9.56e-08	3	160	3	25977330
Pubmed	The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.	KRAS NRAS HRAS	9.56e-08	3	160	3	28630043
Pubmed	Overexpression of wild-type p21Ras plays a prominent role in colorectal cancer.	KRAS NRAS HRAS	9.56e-08	3	160	3	28259994
Pubmed	The variable phenotype and low-risk nature of RAS-positive thyroid nodules.	KRAS NRAS HRAS	9.56e-08	3	160	3	26253102
Pubmed	Frequency of RAS gene mutation and its cooperative genetic events in Southeast Asian adult acute myeloid leukemia.	KRAS NRAS HRAS	9.56e-08	3	160	3	16573741
Pubmed	Analysis of k-ras nuclear expression in fibroblasts and mesangial cells.	KRAS NRAS HRAS	9.56e-08	3	160	3	20090846
Pubmed	A pericyte origin of spinal cord scar tissue.	KRAS NRAS HRAS	9.56e-08	3	160	3	21737741
Pubmed	Prevalence of RAS point mutations in papillary thyroid carcinoma; a novel mutation at codon 31 of K-RAS.	KRAS NRAS HRAS	9.56e-08	3	160	3	17943694
Pubmed	Deciphering the RAS/ERK pathway in vivo.	KRAS NRAS HRAS	9.56e-08	3	160	3	28202657
Pubmed	Mutational analysis of K-ras and Ras protein expression in larynx squamous cell carcinoma.	KRAS NRAS HRAS	9.56e-08	3	160	3	16761621
Pubmed	Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis.	KRAS NRAS HRAS	9.56e-08	3	160	3	20971740
Pubmed	Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma.	KRAS NRAS HRAS	9.56e-08	3	160	3	27119512
Pubmed	SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.	KRAS NRAS ITGB1 HRAS	1.39e-07	11	160	4	28263956
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RAN ANKFY1 KIF1A POLD1 POR CMYA5 OPA1 UBE4A MFGE8 NCAPG GUCY1B2 SBNO1 DOCK7 CPSF1 CC2D2A ZFR PRKDC BUB3 HSPA5 NUP160 SEC23A AQR SDHA	1.73e-07	1425	160	23	30948266
Pubmed	Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.	KRAS NRAS HRAS	3.81e-07	4	160	3	10085069
Pubmed	Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice.	KRAS NRAS HRAS	3.81e-07	4	160	3	38849523
Pubmed	SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.	KRAS NRAS HRAS	3.81e-07	4	160	3	9674433
Pubmed	Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.	KRAS PRKDC IL2RG	3.81e-07	4	160	3	34388391
Pubmed	Quantification of spatiotemporal patterns of Ras isoform expression during development.	KRAS NRAS HRAS	3.81e-07	4	160	3	28117393
Pubmed	The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions.	KRAS NRAS HRAS	3.81e-07	4	160	3	27936046
Pubmed	Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.	KRAS NRAS HRAS	3.81e-07	4	160	3	29502968
Pubmed	Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.	KRAS NRAS HRAS	3.81e-07	4	160	3	7972015
Pubmed	Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis.	KRAS NRAS HRAS	3.81e-07	4	160	3	10490827
Pubmed	Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.	KRAS NRAS HRAS	3.81e-07	4	160	3	25999467
Pubmed	PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.	KRAS PRKDC IL2RG	3.81e-07	4	160	3	29533781
Pubmed	A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.	PTCH1 PRKDC IL2RG	3.81e-07	4	160	3	29474906
Pubmed	The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery.	INTU WDPCP CPLANE1	3.81e-07	4	160	3	27158779
Pubmed	Targeted Long-Read Sequencing Decodes the Transcriptional Atlas of the Founding RAS Gene Family Members.	KRAS NRAS HRAS	3.81e-07	4	160	3	34948093
Pubmed	Ras membrane orientation and nanodomain localization generate isoform diversity.	KRAS NRAS HRAS	3.81e-07	4	160	3	20080631
Pubmed	Defining the membrane proteome of NK cells.	KRAS RAN NRAS POLD1 POR RFFL ITGB1 CIT NCAPG2 OPA1 MFGE8 LARP4B NCAPG PRRC2C CLPTM1 PRKDC IL2RG HSPA5 CNOT2 AQR	4.75e-07	1168	160	20	19946888
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	RAN FAT4 POR MAGEC3 ITGB1 LSR FAT1 PLEKHM2 VPS13A DOCK7 ZFR PRKDC NUP160 SEC23A AGAP1 AGAP3	6.78e-07	777	160	16	35844135
Pubmed	Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin.	KRAS NRAS HRAS	9.49e-07	5	160	3	22982107
Pubmed	The complexity of Raf-1 regulation.	KRAS NRAS HRAS	9.49e-07	5	160	3	9069260
Pubmed	Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions.	KRAS NRAS HRAS	9.49e-07	5	160	3	34535655
Pubmed	Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma.	KRAS PRKDC IL2RG	9.49e-07	5	160	3	34848557
Pubmed	Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer.	KRAS PRKDC IL2RG	9.49e-07	5	160	3	37802055
Pubmed	Impeded Nedd4-1-mediated Ras degradation underlies Ras-driven tumorigenesis.	KRAS NRAS HRAS	9.49e-07	5	160	3	24746824
Pubmed	Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation.	KRAS NRAS HRAS	9.49e-07	5	160	3	15558479
Pubmed	Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.	PTCH1 PRKDC IL2RG	1.89e-06	6	160	3	24954133
Pubmed	The emerging mechanisms of isoform-specific PI3K signalling.	PIK3R3 PIK3CB PIK3CD	1.89e-06	6	160	3	20379207
Pubmed	Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival.	PIK3R3 PIK3CB PIK3CD	1.89e-06	6	160	3	10949031
Pubmed	Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth.	KRAS NRAS HRAS	1.89e-06	6	160	3	29615452
Pubmed	AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53.	KRAS PRKDC IL2RG	1.89e-06	6	160	3	34303658
Pubmed	Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf.	KRAS NRAS HRAS	1.89e-06	6	160	3	9753431
Pubmed	FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.	KRAS NRAS HRAS	1.89e-06	6	160	3	21072204
Pubmed	Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1.	KRAS NRAS HRAS	1.89e-06	6	160	3	10882715
Pubmed	LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases.	KRAS NRAS HRAS	1.89e-06	6	160	3	31337872
Pubmed	Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.	EOMES TPX2 DOCK7 TBR1	1.97e-06	20	160	4	32294449
Pubmed	14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.	SRGAP2 INO80 REXO1 PPP2R1B DOCK7 HSPA5 VASP SEC23A	2.57e-06	186	160	8	14744259
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	KRAS ABCC3 NRAS DAPK1 ITGB1 LSR FAT1 PTPRJ HRAS DOCK7 TACSTD2 PCDH1 AGAP1	2.58e-06	569	160	13	30639242
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DCTN2 POLD1 MAGEE2 PPP2R1B NCAPG TPX2 CPSF1 PRKDC BUB3 HSPA5 VASP SEC23A AQR	3.29e-06	582	160	13	20467437
Pubmed	Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.	KRAS NRAS HRAS	3.30e-06	7	160	3	20526288
Pubmed	PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.	KRAS PRKDC IL2RG	3.30e-06	7	160	3	28087712
Pubmed	Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.	KRAS NRAS HRAS	3.30e-06	7	160	3	35904492
Pubmed	SmgGDS displays differential binding and exchange activity towards different Ras isoforms.	KRAS NRAS HRAS	3.30e-06	7	160	3	11948427
Pubmed	Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension.	KRAS NRAS HRAS	3.30e-06	7	160	3	20860430
Pubmed	Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.	KRAS NRAS HRAS	3.30e-06	7	160	3	22199277
Pubmed	Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation.	KRAS PRKDC IL2RG	3.30e-06	7	160	3	29334357
Pubmed	Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1.	KRAS NRAS HRAS	3.30e-06	7	160	3	19487299
Pubmed	Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.	FAT4 FAT1 RERE	3.30e-06	7	160	3	22510986
Pubmed	H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice.	KRAS NRAS HRAS	3.30e-06	7	160	3	20179099
Pubmed	The structural basis of the activation of Ras by Sos.	KRAS NRAS HRAS	3.30e-06	7	160	3	9690470
Pubmed	DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.	KRAS PRKDC IL2RG	3.30e-06	7	160	3	29431745
Pubmed	Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.	KRAS RAN NRAS HRAS DOCK7 HSPA5	3.66e-06	89	160	6	27034005
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	KRAS NRAS HRAS IL2RG	5.06e-06	25	160	4	8493579
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	KRAS RAN MED10 DCTN2 POLD1 INPPL1 ITGB1 CIT OPA1 TULP4 HRAS CPSF1 PRKDC BUB3 HSPA5 CNOT2 VASP AQR SDHA	5.12e-06	1247	160	19	27684187
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KBTBD3 INTU CDH26 KIF1A PIK3R3 FRMPD2 PON2 LAMA3 FBXL17 SRGAP2 GRHL2 ITGB1 PPP2R1B PTPRJ TULP4 ATXN1 RERE PCDH1 ADAT2 AGAP1 AGAP3	5.19e-06	1489	160	21	28611215
Pubmed	Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.	PIK3R3 PIK3CB PIK3CD	5.26e-06	8	160	3	17846664
Pubmed	Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.	KRAS NRAS HRAS	5.26e-06	8	160	3	20150892
Pubmed	Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes.	PIK3R3 ITGB1 PIK3CB	5.26e-06	8	160	3	22402981
Pubmed	Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.	KRAS NRAS HRAS	5.26e-06	8	160	3	15064703
Pubmed	RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.	PIK3CB PIK3CD HRAS	5.26e-06	8	160	3	23706742
Pubmed	The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.	KRAS NRAS HRAS	7.87e-06	9	160	3	10783161
Pubmed	Chondrocyte proliferation regulated by secreted luminal domain of ER stress transducer BBF2H7/CREB3L2.	PTCH1 HSPA5 SEC23A	7.87e-06	9	160	3	24332809
Pubmed	Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo.	CYP11B1 CYP11B2 POR	7.87e-06	9	160	3	7588219
Interaction	CYP11B1 interactions	KRAS CYP11B1 CYP11B2 CIT	1.76e-08	5	157	4	int:CYP11B1
Interaction	TPR interactions	KRAS RAN DCTN2 POLD1 ITGB1 CIT UBE4A ATXN1 PIK3CB PRRC2C HRAS PRKDC NUP160 SDHA	4.47e-08	281	157	14	int:TPR
Interaction	PIK3CG interactions	KRAS NRAS CIT PIK3CD HRAS EPHA8	6.51e-06	59	157	6	int:PIK3CG
Interaction	GAB2 interactions	KRAS RAN NRAS SRGAP2 PIK3CB HRAS HSPA5 AGAP1	8.25e-06	130	157	8	int:GAB2
Interaction	HEPH interactions	KRAS NRAS HRAS	9.12e-06	6	157	3	int:HEPH
Interaction	ACTN4 interactions	ATP6V1B1 ANKFY1 INPPL1 LAMA3 DAPK1 INO80 ITGB1 CIT NCAPG2 CIBAR1 AGRN HSPA5 VASP	1.57e-05	400	157	13	int:ACTN4
Interaction	DOCK5 interactions	KRAS INTU KIF1A PIK3R3 ATXN1 PIK3CB HRAS	2.63e-05	111	157	7	int:DOCK5
Interaction	UCN3 interactions	FAT4 FAT1 HERC1 HSPA5	2.80e-05	23	157	4	int:UCN3
Interaction	CMA1 interactions	FAT4 PON2 VWDE FAT1 HSPA5	2.85e-05	46	157	5	int:CMA1
Interaction	EHD1 interactions	KRAS ANKFY1 NRAS RFFL OPA1 ATXN1 HRAS PRKDC	3.25e-05	157	157	8	int:EHD1
Interaction	RANBP1 interactions	KRAS RAN CIT HIRA NUP54 ATXN1 AGRN HSPA5 NUP160	4.23e-05	211	157	9	int:RANBP1
Interaction	UNC5B interactions	KRAS NRAS DAPK1 PPP2R1B HRAS EPHA8	5.00e-05	84	157	6	int:UNC5B
Interaction	UBXN6 interactions	KRAS POLD1 POR QRICH1 ARMCX5 NCAPG HRAS DOCK7 PRKDC HERC1 GPAT2	5.01e-05	325	157	11	int:UBXN6
Interaction	LYPD4 interactions	KRAS KIF1A CIT VWDE FAT1 AP5Z1 HSPA5	5.08e-05	123	157	7	int:LYPD4
Interaction	TRPV2 interactions	KRAS NRAS HRAS	5.35e-05	10	157	3	int:TRPV2
Interaction	SPSB4 interactions	FAT4 KIF1A NUP54 UBE4A FAT1 PCDH1 DDX4	5.35e-05	124	157	7	int:SPSB4
Interaction	FAM135A interactions	KRAS ANKFY1 NRAS HRAS VASP EPHA8	5.71e-05	86	157	6	int:FAM135A
Interaction	TOP3B interactions	ABCC3 INPPL1 RAP1GAP2 SRGAP2 INO80 PTCH1 CIT REXO1 HIRA DIP2A LARP4B FAT1 TULP4 PLEKHM2 PIK3CD CPSF1 ZFR PRKDC HERC1 LSM10 AGRN HSPA5 CNOT2 SEC23A SDHA AGAP3	6.81e-05	1470	157	26	int:TOP3B
Interaction	PLCD1 interactions	KRAS NRAS FBXL4 HRAS RAB39B	7.46e-05	56	157	5	int:PLCD1
Interaction	CDK16 interactions	KRAS NRAS INPPL1 SRGAP2 NUP54 SEC23A AGAP1	7.95e-05	132	157	7	int:CDK16
Interaction	GTSF1 interactions	KRAS NRAS HRAS	9.69e-05	12	157	3	int:GTSF1
Interaction	HCFC1 interactions	KRAS RAN NRAS CIT ATXN1 PRRC2C CIBAR1 RERE BUB3 HSPA5	1.03e-04	293	157	10	int:HCFC1
Interaction	INSR interactions	KRAS ZWILCH NRAS INPPL1 PIK3R3 PON2 ITGB1 FAT1 HRAS HSPA5 SEC23A	1.05e-04	353	157	11	int:INSR
Interaction	CD44 interactions	KRAS NRAS LAMA3 POR ITGB1 CIT HRAS HSPA5 AQR	1.10e-04	239	157	9	int:CD44
Interaction	RASGRP2 interactions	KRAS NRAS DAPK1	1.25e-04	13	157	3	int:RASGRP2
Interaction	DEPDC1B interactions	KRAS ANKFY1 NRAS SRGAP2 LARP4B HRAS ZFR AGAP1	1.34e-04	192	157	8	int:DEPDC1B
Interaction	EEF1AKMT3 interactions	POLD1 QRICH1 ARMCX5 LARP4B NCAPG DOCK7 HERC1 GPAT2 HSPA5 AQR AGAP3	1.37e-04	364	157	11	int:EEF1AKMT3
Interaction	VEGFB interactions	PPM1M ITGB1 VWDE FAT1	1.37e-04	34	157	4	int:VEGFB
Interaction	FLNB interactions	RAN DCTN2 ITGB1 CIT MAP3K1 ATXN1 PRRC2C C1D AGRN HSPA5	1.40e-04	304	157	10	int:FLNB
Interaction	ITGB6 interactions	KRAS NRAS HRAS	1.59e-04	14	157	3	int:ITGB6
Interaction	EPHA2 interactions	KRAS ANKFY1 NRAS INPPL1 PIK3R3 SRGAP2 ITGB1 OPA1 UBE4A LSR CIBAR1 TPX2 HRAS SDHA AGAP1 EPHA8	1.61e-04	719	157	16	int:EPHA2
GeneFamily	SH2 domain containing	INPPL1 PIK3R3 TEC STAT2 CISH SHE	3.51e-05	101	110	6	741
GeneFamily	Cytochrome P450 family 11	CYP11B1 CYP11B2	1.10e-04	3	110	2	1007
GeneFamily	Cadherin related	FAT4 CDHR1 FAT1	1.40e-04	17	110	3	24
GeneFamily	Ankyrin repeat domain containing\|Death associated protein kinases	STK17B DAPK1	3.62e-04	5	110	2	1021
GeneFamily	Fibronectin type III domain containing	COL12A1 CMYA5 PTPRJ TNR IL2RG EPHA8	4.39e-04	160	110	6	555
GeneFamily	Blood group antigens\|CD molecules\|Proteoglycans	TGFBR3 AGRN	7.55e-04	7	110	2	570
GeneFamily	RAS type GTPase family	KRAS NRAS HRAS	8.70e-04	31	110	3	389
GeneFamily	Phosphatidylinositol 3-kinase subunits	PIK3CB PIK3CD	1.00e-03	8	110	2	831
ToppCell	T_cells-CTLs\|World / Immune cells in Kidney/Urine in Lupus Nephritis	LITAF RAP1GAP2 PTCH1 ADGRE2 ITGB1 EOMES TGFBR3 DIP2A IL2RG	4.20e-08	197	160	9	2de34e20915a247bee75aa40495e23c20bb23e18
ToppCell	T_cells-CTLs\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	KRAS LITAF RAP1GAP2 PTCH1 ADGRE2 ITGB1 EOMES TGFBR3 AGAP1	4.20e-08	197	160	9	28117cf300e169182571fbad0de1681a484a435a
ToppCell	CD8+_Memory_T_cell-CV-0\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	KLHL24 LITAF ADGRE2 EOMES TGFBR3 PTPRJ ATXN1 IL2RG	5.07e-07	193	160	8	995781d87a919c0380750878bafe584342bb83ad
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CDH26 KIF1A CIT NCAPG2 VWDE ACOX2 CFAP65 CNNM1	6.15e-07	198	160	8	d6812494874be0c14361ac2ac3e418b335bb8f55
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FAT4 INTU RARRES1 CMYA5 PTCH1 SORCS1 TGFBR3 FAT1	6.39e-07	199	160	8	38cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCell	Calu_3\|World / Cell line, Condition and Strain	RARRES1 KIF1A LAMA3 GRHL2 LSR TACSTD2 PCDH1 AGRN	6.63e-07	200	160	8	a549aa08aeefe905653266dae3936094ff55f8e4
ToppCell	AT1-AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	ABCC3 COL12A1 LAMA3 LSR LOXL4 TACSTD2 AGRN	3.01e-06	172	160	7	0be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZWILCH SRGAP2 CIT NCAPG2 NCAPG TPX2 CC2D2A	3.25e-06	174	160	7	c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZWILCH SRGAP2 CIT NCAPG2 NCAPG TPX2 CC2D2A	3.25e-06	174	160	7	72df66319f6efbd88ecf439013d97409fbf3cb52
ToppCell	(05)_Ciliated-(4)_1wkpi\|(05)_Ciliated / shred by cell type and Timepoint	NRAS CDHR1 GRHL2 CFAP65 AP5Z1 TACSTD2 CCDC17	4.07e-06	180	160	7	85fc9b164147b28545e2397d32302eea03ef6346
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DAPK1 GRHL2 MAP3K1 CNNM1 FAT1 PIK3CB CD200	4.53e-06	183	160	7	92fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCell	COVID-19_Severe-gd_T\|COVID-19_Severe / Disease condition and Cell class	CDHR1 PIK3R3 PTCH1 ADGRE2 TGFBR3 DIP2A AGAP1	4.70e-06	184	160	7	791f1bcb954aadc63d4117c400537d036f68734d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 LAMA3 FAT1 LOXL4 AGRN GPR176 CD200	5.41e-06	188	160	7	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 LAMA3 FAT1 LOXL4 AGRN GPR176 CD200	5.41e-06	188	160	7	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DAPK1 GRHL2 MAP3K1 CNNM1 FAT1 PIK3CB CD200	5.60e-06	189	160	7	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RAN PTCH1 CIT FREM1 NCAPG TPX2 BUB3	5.60e-06	189	160	7	d049f33115610bda4489968759f754730698b9cd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 RAP1GAP2 PON2 DAPK1 GRHL2 MAP3K1 UGT8	5.80e-06	190	160	7	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 RAP1GAP2 PON2 DAPK1 GRHL2 MAP3K1 UGT8	6.00e-06	191	160	7	5a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 RAP1GAP2 PON2 DAPK1 GRHL2 MAP3K1 UGT8	6.00e-06	191	160	7	55ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 RAP1GAP2 PON2 DAPK1 GRHL2 MAP3K1 TACSTD2	6.43e-06	193	160	7	263d185af6ed80e639f864e4966268e0862c61dc
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	RAP1GAP2 EOMES TGFBR3 DIP2A IL2RG PCDH1 VASP	6.43e-06	193	160	7	b53ffef20f918b7d1e9d3924562691d13245e2dd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 RAP1GAP2 PON2 DAPK1 GRHL2 MAP3K1 TACSTD2	6.43e-06	193	160	7	80e058c224749b5fe0ba3e944b48317c2371cb63
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 RAP1GAP2 PON2 DAPK1 GRHL2 MAP3K1 TACSTD2	6.43e-06	193	160	7	b991fbbb4618401624f0b3045f0e81a606d3a763
ToppCell	nucseq-Immune-Immune_Myeloid-pMON-pMON\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RAP1GAP2 SRGAP2 ADGRE2 MAP3K1 PTPRJ PIK3CD MX2	6.65e-06	194	160	7	e237384b02be460d44eeada3026a5691c66f6fc1
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 RAP1GAP2 LAMA3 DAPK1 GRHL2 MAP3K1 PTPRJ	6.65e-06	194	160	7	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	nucseq-Immune-Immune_Myeloid-pMON\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RAP1GAP2 SRGAP2 ADGRE2 MAP3K1 PTPRJ PIK3CD MX2	6.65e-06	194	160	7	0bc83ae79873a5e473e6e1e3111924cd003986a1
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAMTSL1 LAMA3 GRHL2 CIT VWDE NCAPG TPX2	6.65e-06	194	160	7	c197e4acbff42a9f0410b6801c2bfcf6160aefc1
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF1A TULP4 PRRC2C VPS13A ZFR RERE HERC1	6.87e-06	195	160	7	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	COVID-19_Severe-Lymphoid_T/NK-gd_T\|COVID-19_Severe / Disease group, lineage and cell class	PTCH1 ADGRE2 EOMES TGFBR3 DIP2A IL2RG AGAP1	6.87e-06	195	160	7	9990440bda7fac5d00ef80444fab07459be625e1
ToppCell	CV-Mild-0\|Mild / Virus stimulation, Condition and Cluster	LITAF PPM1M ADGRE2 EOMES TGFBR3 ATXN1 IL2RG	6.87e-06	195	160	7	2ffb9a9b6143bb404fe454cd939b573252bba6e9
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PTCH1 ADGRE2 EOMES TGFBR3 DIP2A IL2RG AGAP1	7.11e-06	196	160	7	418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PTCH1 ADGRE2 EOMES TGFBR3 DIP2A IL2RG AGAP1	7.11e-06	196	160	7	581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCell	Children_(3_yrs)-Immune-monocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	STK17B RAP1GAP2 SRGAP2 ADGRE2 MAP3K1 PTPRJ PIK3CD	7.11e-06	196	160	7	cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PTCH1 ADGRE2 EOMES TGFBR3 DIP2A IL2RG AGAP1	7.11e-06	196	160	7	6beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PTCH1 ADGRE2 EOMES TGFBR3 DIP2A IL2RG AGAP1	7.11e-06	196	160	7	c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LITAF RAP1GAP2 PTCH1 ITGB1 TGFBR3 IL2RG AGAP1	7.35e-06	197	160	7	ff34be81ee77efe60618641fa7c1084442b991d7
ToppCell	CV-Severe-0\|Severe / Virus stimulation, Condition and Cluster	KLHL24 LITAF ADGRE2 TGFBR3 PTPRJ ATXN1 IL2RG	7.35e-06	197	160	7	d13fc20b31ab6d9117437fba319c72f3a552858f
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LITAF RAP1GAP2 EOMES TGFBR3 DIP2A ATXN1 IL2RG	7.35e-06	197	160	7	8e41e6cda38eace961cb1a56f4df24468c66b956
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RARRES1 STK17B GRHL2 LSR TRIM16L TACSTD2 IL2RG	7.59e-06	198	160	7	3371276410dba693c238b383d990b89371b14d8d
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CCDC28B LITAF RAP1GAP2 PTCH1 ITGB1 TGFBR3 B4GALT4	7.59e-06	198	160	7	88bb764b21ca50e56f6c536a2d61d35afd8c3f36
ToppCell	COVID_non-vent-Lymphocytic-ILC-NK_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	LITAF PTCH1 EOMES TGFBR3 DIP2A IL2RG AGAP1	7.85e-06	199	160	7	ed35d747f11f6ea6a5cb7061057f0a98d9e0db99
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	FBXL17 WDPCP PTPRJ ATXN1 RERE HERC1 AGAP1	7.85e-06	199	160	7	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	COVID_non-vent-Lymphocytic-ILC\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	LITAF PTCH1 EOMES TGFBR3 DIP2A IL2RG AGAP1	7.85e-06	199	160	7	df4f7d5be099e3e6054f3b812ccf70251664e4c0
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LITAF RAP1GAP2 PTCH1 ITGB1 TGFBR3 DIP2A B4GALT4	7.85e-06	199	160	7	00ef3cc5c02639bfb839075ecf5f20026ff81f84
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 PON2 LAMA3 DAPK1 ITGB1 TACSTD2 AGRN	8.11e-06	200	160	7	741e59c68ae4a3a7be830e98771a14f920c9e883
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 PON2 LAMA3 DAPK1 ITGB1 TACSTD2 AGRN	8.11e-06	200	160	7	55b7b17f2d413b9ebb262ef8bd210ef45618a7f3
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-HS3ST3A1-L3-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FAT4 CDHR1 PON2 LAMA3 VWDE SHE SLC47A1	8.11e-06	200	160	7	06ea96428728199a30a0f836647d6448287d3848
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-HS3ST3A1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FAT4 CDHR1 PON2 LAMA3 VWDE SHE SLC47A1	8.11e-06	200	160	7	dd68ce6934eafb75d918042fcf7fd7a750294b7f
ToppCell	Children_(3_yrs)-Immune-monocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	STK17B RAP1GAP2 SRGAP2 ADGRE2 MAP3K1 PTPRJ PIK3CD	8.11e-06	200	160	7	881ab995c90d75fd987d6e8f1f926a4bfcc4235f
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	FAT4 RARRES1 PTCH1 SORCS1 NDST3 TGFBR3 FAT1	8.11e-06	200	160	7	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	severe\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MED10 LITAF STK17B ITGB1 PRRC2C IL2RG HSPA5	8.11e-06	200	160	7	accc618d6b960bff30cb531c1226295bfc8650f6
ToppCell	severe-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MED10 LITAF ITGB1 TGFBR3 IL2RG HSPA5 AGAP1	8.11e-06	200	160	7	6aa77955017d073a96324e4db6b9950a2ec46cf8
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-gd_T\|COVID-19_Severe / Disease, condition lineage and cell class	PIK3R3 PTCH1 EOMES TGFBR3 DIP2A IL2RG AGAP1	8.11e-06	200	160	7	f72bc3f6606ae77fe1b0a972e35b3ce0727804d9
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FAT4 CDHR1 EOMES TGFBR3 IL2RG TEC	2.66e-05	162	160	6	9b1c07f0af657095379380c39d763cab0ad73e74
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	LITAF PTCH1 ITGB1 TGFBR3 DIP2A IL2RG	3.27e-05	168	160	6	b94b1f37c92e019d01ecfa3b7cc6797b6e4a56ff
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-CD4_CTL\|ICU-NoSEP / Disease, Lineage and Cell Type	LITAF ITGB1 CISH TGFBR3 IL2RG AGAP1	3.38e-05	169	160	6	cbda36f32bd78322dcfe303a44413415d08e5ea3
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CMYA5 PTCH1 SHE IL2RG PCDH1 CD200	3.49e-05	170	160	6	55fe16d98ea284d05fb899888e4569c685644c7b
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-Sox9_Epi-Sox9_Epi_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZWILCH CIT LSR NCAPG TPX2 BUB3	3.61e-05	171	160	6	621f9da0bfa09c86fc89fd26919403e94cd56d2b
ToppCell	NS-moderate-d_07-13-Lymphoid-NK\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FAT4 SORCS1 MFGE8 SHE GPR176 CD200	4.10e-05	175	160	6	f6cd24d22f62469319f9d244e3e5de527d3d4d94
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	ABCC3 COL12A1 LAMA3 LOXL4 GPR176 CD200	4.66e-05	179	160	6	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTCH1 GRHL2 NCAPG2 CRHBP ALKBH8 NUP160	4.66e-05	179	160	6	4166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCell	ILEUM-non-inflamed-(8)_Fibroblast-(8)_Activated_fibroblasts\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ABCC3 ANKFY1 INPPL1 AP5Z1 TPX2 HRAS	4.66e-05	179	160	6	5787ffba96918db80256ced076a455a84ba01384
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 COL12A1 CDHR1 LAMA3 VWDE TGFBR3	4.66e-05	179	160	6	01302505816f272243659e20d751b61a198a2fc0
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIT NCAPG2 NCAPG PIK3CB TPX2 AGAP1	4.95e-05	181	160	6	566249e04dd491e6287ad2101b7b1ab11031ed8b
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIT NCAPG2 NCAPG PIK3CB TPX2 AGAP1	4.95e-05	181	160	6	db9528dc7cb0230e4c36cb27da69102c588c7ee9
ToppCell	(00)_Basal-(0)_uninjured\|(00)_Basal / shred by cell type and Timepoint	ATP6V1B1 TGFBR3 FAT1 SLC47A1 AGRN CD200	5.11e-05	182	160	6	c02c9cab4389d80f318f4bb8d703c1e719672624
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DAPK1 GRHL2 MAP3K1 CNNM1 FAT1 CD200	5.11e-05	182	160	6	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DAPK1 MAP3K1 CNNM1 FAT1 PIK3CB CD200	5.26e-05	183	160	6	738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCell	normal-na-Lymphocytic_T-CytoT_GZMH+-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	LITAF PIK3R3 EOMES TGFBR3 TBR1 IL2RG	5.59e-05	185	160	6	097d628f92e13250c15b550f2fd1f4225fc07558
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK17B RFFL MAP3K1 PIK3CD IL2RG VASP	5.59e-05	185	160	6	a2cae8c657e4f4d121476798e424876f7e247973
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK17B RFFL MAP3K1 PIK3CD IL2RG VASP	5.59e-05	185	160	6	d50406a9a5b8d75110ba5985741aa2293950c543
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DAPK1 GRHL2 MAP3K1 CNNM1 FAT1 CD200	5.76e-05	186	160	6	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	Healthy/Control-CD4+_CTL\|World / Disease group and Cell class	MED10 ITGB1 EOMES TGFBR3 IL2RG AGAP1	5.93e-05	187	160	6	d54d3214d77a9469e94a16c00a80626fd4953e2b
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LITAF PTCH1 TGFBR3 FAT1 ATXN1 HSPA5	5.93e-05	187	160	6	173f029dcf32af008f517912f6d110a33a9e98cf
ToppCell	(04)_Pre-ciliated-(3)_72hpi\|(04)_Pre-ciliated / shred by cell type and Timepoint	NRAS ACOX2 CFAP65 C20orf96 TPX2 CCDC17	6.11e-05	188	160	6	f911dc61b008b60aaa2a1e9354085f480a669e2c
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAMTSL1 COL12A1 LAMA3 GRHL2 TACSTD2 AGRN	6.11e-05	188	160	6	eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCell	LPS_only-Lymphocytic_NKT\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK17B TEC EOMES PIK3CD IL2RG CA6	6.11e-05	188	160	6	bbe65b1c11c88ab62d8485cfc3a913ff9da89aad
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PTCH1 GRHL2 FREM1 SORCS1 RERE AGAP1	6.11e-05	188	160	6	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	FAT4 COL12A1 RARRES1 PTCH1 TGFBR3 FAT1	6.29e-05	189	160	6	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	Control-Myeloid-Monocytes\|Control / group, cell type (main and fine annotations)	STK17B RAP1GAP2 SRGAP2 ADGRE2 MAP3K1 MX2	6.29e-05	189	160	6	3335d16bd0ffa0c1ddd06d7da645299148130c3f
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRELID1 LITAF STK17B ADGRE2 VASP MX2	6.48e-05	190	160	6	57800d807785b9d539b47945a0a74631f5e88a06
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP6V1B1 USP37 MAP3K1 CISH HSPA5 CD200	6.48e-05	190	160	6	92456f6f7eced6e4c4371f495254a65d061c8d0b
ToppCell	ILEUM-non-inflamed-(8)_Activated_fibroblasts\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ABCC3 COL12A1 ANKFY1 TPX2 HRAS AGAP1	6.48e-05	190	160	6	39fa110d19c97c7cac99f5fb91b26bc08e2f3b42
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRELID1 LITAF STK17B ADGRE2 ADA2 MX2	6.67e-05	191	160	6	1c7d31684654ca6a046d8cc816af1fdc42369c57
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRELID1 LITAF STK17B ADGRE2 ADA2 MX2	6.67e-05	191	160	6	d60d81d2045c6e624bbc8b17e13a32f7921d969f
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADAMTSL1 LAMA3 GRHL2 CIT NCAPG TPX2	6.67e-05	191	160	6	39220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAMTSL1 PON2 LAMA3 DAPK1 GRHL2 LARP4B	6.67e-05	191	160	6	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	SECISBP2L ADAMTSL1 PON2 LAMA3 DAPK1 GRHL2	6.67e-05	191	160	6	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	P03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RAN ZWILCH CIT NCAPG2 NCAPG TPX2	6.67e-05	191	160	6	b978afe76754cc56e1672abca27be289bb56375b
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RAN CIT NCAPG2 NCAPG TPX2 BUB3	6.67e-05	191	160	6	f764cc21fef87ebad765011098f647ae1bdf6158
ToppCell	IPF-Epithelial-Basal\|World / Disease state, Lineage and Cell class	CDH26 LAMA3 GRHL2 FAT1 LOXL4 TACSTD2	6.87e-05	192	160	6	9b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-NK\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LITAF RAP1GAP2 EOMES TGFBR3 DIP2A IL2RG	6.87e-05	192	160	6	a06d5d3c2537f8d2b1dc6b6f3e88a80b5c2a1850
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	FBXL17 SORCS1 PTPRJ ATXN1 RERE AGAP1	6.87e-05	192	160	6	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FAT4 COL12A1 PTCH1 NDST3 FAT1 CD200	6.87e-05	192	160	6	72881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-CD4+_CTL\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MED10 LITAF ITGB1 TGFBR3 IL2RG HSPA5	7.07e-05	193	160	6	a4ba77be93d8786c41994eda97902fcd7381dd36
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	INTU FRMPD2 WDPCP CFAP65 CPLANE1 CCDC17	7.07e-05	193	160	6	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	COL12A1 RARRES1 PTCH1 NDST3 FAT1 CD200	7.07e-05	193	160	6	2f203f6f0c2135acb046c9351a633c3b5b254a46
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-CD4+_CTL\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	MED10 LITAF ITGB1 TGFBR3 IL2RG HSPA5	7.07e-05	193	160	6	22ba8f27184c70ccab999d40904fe18abf99f190
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 RAP1GAP2 LAMA3 DAPK1 MAP3K1 PTPRJ	7.07e-05	193	160	6	42df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-CD8_TEM\|ICU-NoSEP / Disease, Lineage and Cell Type	LITAF ITGB1 EOMES TGFBR3 BUB3 IL2RG	7.07e-05	193	160	6	848d47d3b1035f0fb36911d71d48976ee9d013fc
Drug	L 744832	KRAS NRAS HRAS	1.30e-06	4	158	3	ctd:C096898
Drug	3-isoreserpine	ABCC3 PIK3R3 TGFBR3 PIK3CB PIK3CD VPS13A LOXL4 SHE DDX4	7.48e-06	190	158	9	CID000005052
Drug	N-acetylglucosaminolactone	PIK3R3 POR OPA1 HIRA PIK3CB PIK3CD	9.23e-06	70	158	6	CID000087901
Drug	Cortisone [53-06-5]; Down 200; 11uM; HL60; HT_HG-U133A	SCAMP4 KIF1A POR ADGRE2 ADA2 CISH PPP2R1B PIK3CD AGRN	1.13e-05	200	158	9	2385_DN
Disease	heart disease (implicated_via_orthology)	KRAS NRAS CYP11B1 PIK3CB PIK3CD HRAS	4.58e-08	38	155	6	DOID:114 (implicated_via_orthology)
Disease	Verrucous epidermal nevus	KRAS NRAS HRAS	1.42e-07	3	155	3	C0362030
Disease	Nevus Sebaceus of Jadassohn	KRAS NRAS HRAS	1.42e-07	3	155	3	C4552097
Disease	Organoid Nevus Phakomatosis	KRAS NRAS HRAS	1.42e-07	3	155	3	C0265329
Disease	Linear nevus sebaceous syndrome	KRAS NRAS HRAS	1.42e-07	3	155	3	cv:C4552097
Disease	Nevus sebaceous	KRAS NRAS HRAS	1.42e-07	3	155	3	C3854181
Disease	Inflammatory linear verrucous epidermal nevus	KRAS NRAS HRAS	1.42e-07	3	155	3	C0473574
Disease	SCHIMMELPENNING-FEUERSTEIN-MIMS SYNDROME	KRAS NRAS HRAS	1.42e-07	3	155	3	163200
Disease	linear nevus sebaceous syndrome (is_implicated_in)	KRAS NRAS HRAS	1.42e-07	3	155	3	DOID:0111530 (is_implicated_in)
Disease	Noonan syndrome 3 (implicated_via_orthology)	KRAS NRAS HRAS	1.42e-07	3	155	3	DOID:0060581 (implicated_via_orthology)
Disease	Linear Verrucous Epidermal Nevus	KRAS NRAS HRAS	1.42e-07	3	155	3	C3179502
Disease	cervical cancer (implicated_via_orthology)	KRAS NRAS HRAS	1.42e-07	3	155	3	DOID:4362 (implicated_via_orthology)
Disease	NEVUS, EPIDERMAL (disorder)	KRAS NRAS HRAS	1.41e-06	5	155	3	C0334082
Disease	Follicular thyroid carcinoma	KRAS NRAS HRAS	1.41e-06	5	155	3	C0206682
Disease	Hemimegalencephaly	KRAS NRAS HRAS	2.81e-06	6	155	3	C0431391
Disease	high grade glioma (implicated_via_orthology)	KRAS NRAS PIK3CB PIK3CD HRAS	3.45e-06	44	155	5	DOID:3070 (implicated_via_orthology)
Disease	RASopathy (implicated_via_orthology)	KRAS NRAS HRAS	1.17e-05	9	155	3	DOID:0080690 (implicated_via_orthology)
Disease	androstenedione measurement	CYP11B1 CYP11B2 ADGRE2	1.66e-05	10	155	3	EFO_0007972
Disease	colorectal cancer (implicated_via_orthology)	KRAS NRAS POLD1 HRAS	1.80e-05	30	155	4	DOID:9256 (implicated_via_orthology)
Disease	Noonan Syndrome 1	KRAS NRAS HRAS	2.27e-05	11	155	3	C4551602
Disease	Turner Syndrome, Male	KRAS NRAS HRAS	2.27e-05	11	155	3	C0041409
Disease	Female Pseudo-Turner Syndrome	KRAS NRAS HRAS	2.27e-05	11	155	3	C1527404
Disease	kidney cancer (implicated_via_orthology)	KRAS NRAS HRAS	2.27e-05	11	155	3	DOID:263 (implicated_via_orthology)
Disease	RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER	KRAS NRAS	2.74e-05	2	155	2	614470
Disease	Glucocorticoid-remediable aldosteronism	CYP11B1 CYP11B2	2.74e-05	2	155	2	C1260386
Disease	Autoimmune lymphoproliferative syndrome type 4	KRAS NRAS	2.74e-05	2	155	2	cv:C2674723
Disease	autoimmune lymphoproliferative syndrome type 4 (is_implicated_in)	KRAS NRAS	2.74e-05	2	155	2	DOID:0110117 (is_implicated_in)
Disease	MELANOCYTIC NEVUS SYNDROME, CONGENITAL	NRAS HRAS	2.74e-05	2	155	2	137550
Disease	Melanocytic nevus	NRAS HRAS	2.74e-05	2	155	2	cv:C0027962
Disease	RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER	KRAS NRAS	2.74e-05	2	155	2	C2674723
Disease	adrenal cortical adenoma (is_marker_for)	CYP11B1 CYP11B2	2.74e-05	2	155	2	DOID:0050891 (is_marker_for)
Disease	large congenital melanocytic nevus (is_implicated_in)	NRAS HRAS	2.74e-05	2	155	2	DOID:0111359 (is_implicated_in)
Disease	Large congenital melanocytic nevus	NRAS HRAS	2.74e-05	2	155	2	cv:C1842036
Disease	RASopathy	KRAS NRAS HRAS	6.18e-05	15	155	3	cv:C5555857
Disease	Rhabdomyosarcoma	PMS2 PTCH1 HRAS	6.18e-05	15	155	3	C0035412
Disease	GIANT PIGMENTED HAIRY NEVUS	NRAS HRAS	8.20e-05	3	155	2	C1842036
Disease	congenital adrenal hyperplasia (implicated_via_orthology)	CYP11B1 CYP11B2	8.20e-05	3	155	2	DOID:0050811 (implicated_via_orthology)
Disease	glioblastoma (is_marker_for)	KRAS PIK3CB PIK3CD HRAS	8.44e-05	44	155	4	DOID:3068 (is_marker_for)
Disease	interleukin 17 measurement	NHLRC1 PTPRJ NUP160 EPHA8	9.23e-05	45	155	4	EFO_0008174
Disease	Bladder Neoplasm	KRAS ANKFY1 POR EOMES HRAS LOXL4	1.00e-04	140	155	6	C0005695
Disease	Malignant neoplasm of urinary bladder	KRAS ANKFY1 POR EOMES HRAS LOXL4	1.04e-04	141	155	6	C0005684
Disease	Noonan-Like Syndrome With Loose Anagen Hair	KRAS NRAS HRAS	1.30e-04	19	155	3	C3501846
Disease	Noonan syndrome-like disorder with loose anagen hair	KRAS NRAS HRAS	1.30e-04	19	155	3	C1843181
Disease	Cardio-facio-cutaneous syndrome	KRAS NRAS HRAS	1.30e-04	19	155	3	C1275081
Disease	Costello syndrome (disorder)	KRAS NRAS HRAS	1.30e-04	19	155	3	C0587248
Disease	leukemia (implicated_via_orthology)	KRAS NRAS HRAS	1.30e-04	19	155	3	DOID:1240 (implicated_via_orthology)
Disease	Gastrointestinal Stromal Tumors	KRAS PTCH1 CC2D2A SDHA	1.40e-04	50	155	4	C0238198
Disease	Adenocarcinoma of large intestine	KRAS PMS2 NRAS HRAS PRKDC	1.56e-04	96	155	5	C1319315
Disease	NEVUS, EPIDERMAL	NRAS HRAS	1.63e-04	4	155	2	162900
Disease	Malignant neoplasm of penis	KRAS HRAS	1.63e-04	4	155	2	C0153601
Disease	Penile Neoplasms	KRAS HRAS	1.63e-04	4	155	2	C0030849
Disease	Nevus, Keratinocytic, Nonepidermolytic	NRAS HRAS	1.63e-04	4	155	2	C4011754
Disease	BLADDER CANCER	KRAS HRAS	1.63e-04	4	155	2	109800
Disease	Epidermal nevus	NRAS HRAS	1.63e-04	4	155	2	cv:C0334082
Disease	Malignant tumor of urinary bladder	KRAS HRAS	1.63e-04	4	155	2	cv:C0005684
Disease	synucleinopathy (biomarker_via_orthology)	KIF1A DCTN2	1.63e-04	4	155	2	DOID:0050890 (biomarker_via_orthology)
Disease	Thyroid cancer, nonmedullary, 2	NRAS HRAS	1.63e-04	4	155	2	cv:C4225426
Disease	Malignant tumor of cervix	KRAS HRAS	1.63e-04	4	155	2	C0007847
Disease	epidermal nevus (is_implicated_in)	NRAS HRAS	1.63e-04	4	155	2	DOID:0111162 (is_implicated_in)
Disease	tyrosine-protein kinase TEC measurement	TEC TEC	1.63e-04	4	155	2	EFO_0020830
Disease	THYROID CANCER, NONMEDULLARY, 2	NRAS HRAS	1.63e-04	4	155	2	188470
Disease	LEOPARD Syndrome	KRAS NRAS HRAS	2.03e-04	22	155	3	C0175704
Disease	Noonan Syndrome	KRAS NRAS HRAS	2.65e-04	24	155	3	C0028326
Disease	THYROID CANCER, NONMEDULLARY, 2	NRAS HRAS	2.71e-04	5	155	2	C4225426
Disease	primary hyperaldosteronism (is_implicated_in)	CYP11B1 CYP11B2	2.71e-04	5	155	2	DOID:446 (is_implicated_in)
Disease	Malignant neoplasm of thyroid	KRAS NRAS	2.71e-04	5	155	2	C0007115
Disease	Cetuximab response	KRAS NRAS	2.71e-04	5	155	2	cv:CN077967
Disease	Cervix carcinoma	KRAS HRAS	2.71e-04	5	155	2	C0302592
Disease	Panitumumab response	KRAS NRAS	2.71e-04	5	155	2	cv:CN077999
Disease	follicular lymphoma (implicated_via_orthology)	ATP6V1B1 RARRES1	2.71e-04	5	155	2	DOID:0050873 (implicated_via_orthology)
Disease	Ciliopathies	CCDC28B WDPCP CIBAR1 CC2D2A CPLANE1	2.94e-04	110	155	5	C4277690
Disease	Colorectal Carcinoma	KRAS ABCC3 PMS2 NRAS POLD1 FRMPD2 NDST3 PPP2R1B FAT1 NCAPG TPX2 VPS13A	3.52e-04	702	155	12	C0009402
Disease	carcinoma (implicated_via_orthology)	KRAS FAT4 NRAS HRAS	3.64e-04	64	155	4	DOID:305 (implicated_via_orthology)
Disease	Hereditary non-polyposis colorectal cancer syndrome	KRAS PMS2 PTPRJ	3.79e-04	27	155	3	C1112155
Disease	Conn Syndrome	CYP11B1 CYP11B2	4.06e-04	6	155	2	C1384514
Disease	congenital adrenal hyperplasia (is_implicated_in)	CYP11B1 POR	4.06e-04	6	155	2	DOID:0050811 (is_implicated_in)
Disease	Pleocytosis	KRAS NRAS	4.06e-04	6	155	2	C0151857
Disease	Autoimmune lymphoproliferative syndrome	KRAS NRAS	4.06e-04	6	155	2	cv:CN301239
Disease	Carcinoma in situ of uterine cervix	KRAS HRAS	4.06e-04	6	155	2	C0851140
Disease	seminoma (is_implicated_in)	KRAS HRAS	4.06e-04	6	155	2	DOID:4440 (is_implicated_in)
Disease	Hyperaldosteronism	CYP11B1 CYP11B2	4.06e-04	6	155	2	C0020428
Disease	Leukocytosis	KRAS NRAS	4.06e-04	6	155	2	C0023518
Disease	colorectal cancer (is_implicated_in)	KRAS NRAS FAT1 PTPRJ PIK3CD	4.57e-04	121	155	5	DOID:9256 (is_implicated_in)
Disease	hypertrophic cardiomyopathy (implicated_via_orthology)	KRAS NRAS HRAS	4.70e-04	29	155	3	DOID:11984 (implicated_via_orthology)
Disease	Hereditary Nonpolyposis Colorectal Cancer	KRAS PMS2 PTPRJ	4.70e-04	29	155	3	C1333990
Disease	Squamous cell carcinoma	KRAS PTCH1 ITGB1 HRAS PRKDC	5.11e-04	124	155	5	C0007137
Disease	loneliness measurement	NHLRC1 PTPRJ RERE NUP160 AGAP3	5.11e-04	124	155	5	EFO_0007865
Disease	cardiomyopathy (implicated_via_orthology)	KRAS NRAS HRAS SDHA	5.41e-04	71	155	4	DOID:0050700 (implicated_via_orthology)
Disease	protocadherin alpha-7 measurement	CYP11B1 CYP11B2	5.66e-04	7	155	2	EFO_0801973
Disease	Thyroid cancer, follicular	NRAS HRAS	5.66e-04	7	155	2	C2931367
Disease	hereditary spastic paraplegia (is_implicated_in)	KIF1A AP5Z1	5.66e-04	7	155	2	DOID:2476 (is_implicated_in)
Disease	intestinal cancer (implicated_via_orthology)	KRAS NRAS HRAS	6.31e-04	32	155	3	DOID:10155 (implicated_via_orthology)
Disease	fatty liver disease (biomarker_via_orthology)	ABCC3 OPA1 HSPA5	6.91e-04	33	155	3	DOID:9452 (biomarker_via_orthology)
Disease	Brain Tumor, Primary	DAPK1 PTCH1 HRAS	6.91e-04	33	155	3	C0750974
Disease	Primary malignant neoplasm of brain	DAPK1 PTCH1 HRAS	6.91e-04	33	155	3	C0750979
Disease	Recurrent Brain Neoplasm	DAPK1 PTCH1 HRAS	6.91e-04	33	155	3	C0750977
Disease	Benign neoplasm of brain, unspecified	DAPK1 PTCH1 HRAS	6.91e-04	33	155	3	C0496899
Disease	Neoplasms, Intracranial	DAPK1 PTCH1 HRAS	6.91e-04	33	155	3	C1527390
Disease	prostate cancer (implicated_via_orthology)	KRAS NRAS HRAS	6.91e-04	33	155	3	DOID:10283 (implicated_via_orthology)
Disease	urinary bladder cancer (is_implicated_in)	KRAS PMS2 DAPK1 HRAS	7.00e-04	76	155	4	DOID:11054 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QISQEHTPVALEAYF	PPP2R1B	126	P30154
EIQRFESVHPNIYAI	AGAP3	36	Q96P47
GLNPTAHYNVFVEVV	EOMES	306	O95936
AHYNVFVEVVLADPN	EOMES	311	O95936
HVVVFSLEEPYEIQL	DAPK1	836	P53355
YDAATQEFVIHSPTL	ACOX2	171	Q99424
VQTLAEINPASVHEY	CCDC17	551	Q96LX7
LVDYSITHAEPANVF	CDHR1	606	Q96JP9
PSEVFEHTVLYVTVE	ADAT2	91	Q7Z6V5
EIQRFESVHPNIYSI	AGAP1	16	Q9UPQ3
HVINFDLPSTIDEYV	DDX4	611	Q9NQI0
SVEHNPLYINITVDF	B4GALT4	326	O60513
HYDVQEEDPVLTVIT	ADGRE2	526	Q9UHX3
HVNRTSFYSQDVLVP	ALKBH8	581	Q96BT7
NVVNIVDSFYHPLEV	ADAM20	236	O43506
FEHPVQVEQDTFYTA	BTBD6	471	Q96KE9
ILTVYVHDVNDNSPV	FAT4	981	Q6V0I7
VEEILNVDPVQHTYS	AGRN	51	O00468
IEQIYPVNAISFHNI	BUB3	231	O43684
DVAVQIISNIYHNFP	AQR	831	O60306
EAVYQHLFTRIPVEQ	AP5Z1	386	O43299
LAFPDVVSLVQHYVA	CISH	151	Q9NSE2
HRAQVSVEVLVEYPF	ATXN1	636	P54253
TSVEHIIVNPNAAYD	DCTN2	41	Q13561
HRVVESNFPNQEYTL	CA6	271	P23280
EPYLFVTHFNSLEVI	CIT	1836	O14578
YPFTQDIIHDVGITV	ARMCX5	341	Q6P1M9
TVFQINHSAYQPVIF	NDST3	221	O95803
IQLIQNHFVDEYDPT	HRAS	21	P01112
IQLIQNHFVDEYDPT	KRAS	21	P01116
IQLIQNHFVDEYDPT	NRAS	21	P01111
QYEHDLEVAQTTALP	RAN	196	P62826
ETKVHVQPYQIVFVL	RAB39B	106	Q96DA2
SITHIAIPQEAYNAV	QRICH1	326	Q2TAL8
IQTIFAVTEEFQPVY	ITGB1	331	P05556
DAPFHVVITSYQLVV	INO80	621	Q9ULG1
HTDLTDNDPVTYVVQ	ABCC3	886	O15438
APDEITDEVQVYHSN	KBTBD3	561	Q8NAB2
VQTVYVQHPITFLDR	LITAF	76	Q99732
IAYNHPDVVSVILEQ	ANKFY1	551	Q9P2R3
PLQFTHLEYNVTVQE	FAT1	31	Q14517
FYSAEIAESIQVHSP	FAT1	2186	Q14517
SGTHSIVQEFQVPDY	C20orf96	11	Q9NUD7
NRTVPSAVFDIHVVY	PTPRJ	536	Q12913
QVIVNPHYEVAESDF	LOXL4	696	Q96JB6
YVHIPDDVNITSTIE	LSM10	81	Q969L4
IQLTEAHVPLQDYEA	MAEL	316	Q96JY0
LTEVDPDHFYVFVNT	MAGEC3	241	Q8TD91
VDTSEHIYLLVQQPE	MAGEE2	371	Q8TD90
PQVGHYVVVVEYSTE	LAMA3	951	Q16787
QTVHFTVREAPQIYS	KCTD21	121	Q4G0X4
PNSVHICAVVVEYET	POR	466	P16435
VVYQTVLNVPDTSVF	GPR176	286	Q14439
VHVNLFETPVEAQYV	MFGE8	191	Q08431
TFQPLTAVIYEVQAT	CFAP65	306	Q6ZU64
NEVPFIVRHVVDYIE	FAM13B	36	Q9NYF5
VTVFALSVHYQPVDV	HERC1	1756	Q15751
DQYVPITTVANLDHI	LARP4B	186	Q92615
FILQEEYHLNPETIT	DDX58	616	O95786
PVEIHEYLSAFENSI	C1D	11	Q13901
DSTVQFIFYQPIIHR	ADAMTSL1	286	Q8N6G6
YIHPQQEAFSIQLIS	CPSF1	1066	Q10570
ANAEIEYTFHQAPEV	PCDH1	311	Q08174
HLRIEPTADQFTVYV	FREM1	1111	Q5H8C1
LDVYAHNVETVPELQ	LIAS	231	O43766
QQLHDITVPLEVFEY	MED10	56	Q9BTT4
INHIFEYTNPEDGVT	NUDT7	171	P0C024
VTFSENHGVVIQPAY	CD200	76	P41217
HYVALETVQGIFITP	INTU	801	Q9ULD6
VPATTLYAHFEQANI	NUP54	256	Q7Z3B4
VYLFVVNHPEFKNTV	PON2	126	Q15165
ERVSTHVIENIYLPA	OPA1	626	O60313
DPLTFNSVVELINHY	PIK3R3	126	Q92569
PYQVFTVEHSVSVDK	WDPCP	296	O95876
QHRNIDTLIVDVYPV	GRID2IP	421	A4D2P6
IFEQTQYDVPSLATH	GRHL2	186	Q6ISB3
HPNYFVQTVEVDQLI	KLHL24	261	Q6TFL4
IDVPNVEFALAVYIH	CC2D2A	1586	Q9P2K1
ETVPQLYDFTETHNQ	DOCK7	1251	Q96N67
LVNEINAYAATETPH	CIBAR1	51	A1XBS5
TVITEIPNHVNLDQY	CPLANE1	2306	Q9H799
VPNTEYAVTVQAVLH	COL12A1	1536	Q99715
ISEPEEFITIHYDQV	CRHBP	86	P24387
FEQQVYPTAVHVLET	FBXL4	131	Q9UKA2
QLPEYGVLVHQVFSE	FRMPD2	541	Q68DX3
ADVTHFVAPNSYIDI	DIS3L	506	Q8TF46
LVVNFPNYHQTSEIV	FABP6	91	P51161
VEQLVQQYPHITFST	FBXL17	661	Q9UF56
YEFTESLHNEVVPQD	CMYA5	3421	Q8N3K9
SINEVDESFQPIHTY	EPHA8	56	P29322
LNSIFETIYHGVPVV	UGT8	361	Q16880
VHLAQPFSLQEYIVS	GPAT2	376	Q6NUI2
LDVQPSIFHYTIEAS	CYP11B1	186	P15538
EVQQEVVVSYLPLSH	ACSBG1	316	Q96GR2
FTLVTQHPEVIYTNQ	ADA2	186	Q9NZK5
EIHLYQTFVVQLQDP	IL2RG	121	P31785
RESPHVNNSFYVIII	CDH26	456	Q8IXH8
LDVQPSIFHYTIEAS	CYP11B2	186	P19099
LVEHSYFERPQVASV	DIP2A	231	Q14689
VPHVVQQETTLAYLE	HIRA	906	P54198
THAVVTVPAYFNDAQ	HSPA5	166	P11021
PLQHSFLTEVTDVYE	CCDC28B	76	Q9BUN5
FYQNFSDEIPVEHQV	SCAMP4	21	Q969E2
EAITYAAQQHETFLP	SBNO1	296	A3KN83
THRSNQVTAPEYVFL	SBNO1	981	A3KN83
TEPLIFQQLEIDHYV	POLD1	91	P28340
YPVDVTITNDCHVVV	NHLRC1	176	Q6VVB1
PLGFYHVQNIAVEVT	KIF1A	1046	Q12756
QVTVSNPYHVVILFQ	LSR	91	Q86X29
TIYQVDLPHTAIQEA	PLEKHM2	971	Q8IWE5
EFYPHIVSTDVSQAE	MAP3K1	771	Q13233
YQFQAHTVALVIPFI	TAS2R16	176	Q9NYV7
VHVVYDTFVKPDNEI	REXO1	1086	Q8N1G1
QYAEIVHFTLPDGTQ	ATP6V1B1	61	P15313
VSRIIVHPQFYIIQT	TPSD1	111	Q9BZJ3
VHPQFYIIQTGADIA	TPSD1	116	Q9BZJ3
LHAYIVVQVETPGTE	RAP1GAP2	381	Q684P5
QNTVDEVYVSRPSHF	STAT2	826	P52630
PTAHYNIFVDVILAD	TBR1	246	Q16650
LQTVSHPEVYRVLFD	SH3D21	61	A4FU49
ISAQYPVVDHEFDAV	SDHA	51	P31040
QVVHDANTLYIFAPS	TEC	81	P42680
HVSQDQEEPVYLESV	RFFL	201	Q8WZ73
VAAVHYEQPTIQIEL	TACSTD2	191	P09758
HSVYVLEDSIVDPQN	PRELID1	76	Q9Y255
NIQLDEYFSIIHPQV	GUCY1B2	226	O75343
LNNYASVVIIDDHPE	PRRC2C	1651	Q9Y520
RVIQVEPQAYTDTHD	PTCH1	621	Q13635
PRVINLHEVYENTSE	STK17B	91	O94768
TIPHDIYVFGTQENS	INPPL1	461	O15357
DYTHEPISVEVQLNS	SECISBP2L	1001	Q93073
SEVPDSVYQHLVQDR	RERE	191	Q9P2R6
VPFILTYDFIHVIQQ	PIK3CB	956	P42338
VEFPYVNLHNEVVGI	NUP160	1051	Q12769
TLAIYFEVVNQHNAP	SEC23A	456	Q15436
AQVVPIYAVSHLFEA	SLC47A1	376	Q96FL8
YEHFAELDIPQSVQQ	CLPTM1	146	O96005
LLSYIQSIPVVNEEH	NCAPG	371	Q9BPX3
YSVQRPLHEFITAVQ	NCAPG2	981	Q86XI2
PDYSVHILSDVQFVK	CNNM1	766	Q9NRU3
QDIDFHVPSEYLTNI	CNOT2	411	Q9NZN8
PFEDITQHNYLAQVT	TULP4	586	Q9NRJ4
EPIYTQTVFHNSRAV	VWDE	976	Q8N2E2
HLEYFIAPSVDIQEQ	ZWILCH	446	Q9H900
VQIRNHFSVPLSVYE	VPS13A	1996	Q96RL7
QVSYDDVSVFVIPLH	PPM1M	436	Q96MI6
LIPHQYIVVQDTEDG	SRGAP2	776	O75044
PVGEVENYVIVLTHF	TNR	976	Q92752
PFILTYDFVHVIQQG	PIK3CD	931	O00329
HQYPFVVLNISVDSE	PMS2	316	P54278
HSVEEITDNYPQAIV	PRKDC	3516	P78527
YTCPVITNLEFEVQH	USP37	471	Q86T82
HATIYPTEEELQAVQ	ZFR	731	Q96KR1
TFLPDSEVIQYQTVH	ZNF790	206	Q6PG37
TPEIYVDQNIHEQLV	UBE4A	216	Q14139
VSQQTHEFTVGVYEP	VSIG10L	286	Q86VR7
IDPDSLIVQDHYVFV	SORCS1	366	Q8WY21
QTSAVFDSIPEVVHY	SHE	456	Q5VZ18
VHVVFSTERYNPESL	RARRES1	101	P49788
LPTQVSAIHIEFTEY	UHRF1BP1	501	Q6BDS2
FSVPENGHVYVEVSV	TGFBR3	611	Q03167
VQIYHNPTANSFRVV	VASP	36	P50552
PSTREQFLQYVHDIT	TRIM16L	146	Q309B1
QFLQYVHDITFDPDT	TRIM16L	151	Q309B1
VSTYVPLAQQVEDFH	TPX2	321	Q9ULW0
FEIIVHQYIQQLVEP	MX2	501	P20592