Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	CELSR3 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 DCHS1 PCDH20	1.25e-06	187	87	8	GO:0007156
GeneOntologyBiologicalProcess	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PCDHB13 PCDHB11 PCDHB8 PCDHB6 DCHS1	2.91e-06	53	87	5	GO:0016339
GeneOntologyBiologicalProcess	positive regulation of free ubiquitin chain polymerization	AMBRA1 PINK1	1.76e-05	2	87	2	GO:1904544
GeneOntologyBiologicalProcess	regulation of free ubiquitin chain polymerization	AMBRA1 PINK1	1.76e-05	2	87	2	GO:1904542
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	CELSR3 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 DCHS1 PCDH20	5.31e-05	313	87	8	GO:0098742
GeneOntologyBiologicalProcess	peroxisomal membrane transport	PEX6 ABCD2 PEX26	1.05e-04	22	87	3	GO:0015919
GeneOntologyBiologicalProcess	peroxisomal transport	PEX6 ABCD2 PEX26	1.05e-04	22	87	3	GO:0043574
GeneOntologyBiologicalProcess	anterograde trans-synaptic signaling	RGS14 CACNG8 P2RY4 PCDHB13 PCDHB11 PCDHB8 PCDHB6 SRF ANKS1B KMT2A PPFIA3 PRRT1 PINK1	1.37e-04	931	87	13	GO:0098916
GeneOntologyBiologicalProcess	chemical synaptic transmission	RGS14 CACNG8 P2RY4 PCDHB13 PCDHB11 PCDHB8 PCDHB6 SRF ANKS1B KMT2A PPFIA3 PRRT1 PINK1	1.37e-04	931	87	13	GO:0007268
GeneOntologyBiologicalProcess	trans-synaptic signaling	RGS14 CACNG8 P2RY4 PCDHB13 PCDHB11 PCDHB8 PCDHB6 SRF ANKS1B KMT2A PPFIA3 PRRT1 PINK1	1.49e-04	939	87	13	GO:0099537
GeneOntologyBiologicalProcess	synaptic signaling	RGS14 CACNG8 P2RY4 PCDHB13 PCDHB11 PCDHB8 PCDHB6 SRF ANKS1B KMT2A PPFIA3 PRRT1 PINK1	2.18e-04	976	87	13	GO:0099536
GeneOntologyBiologicalProcess	sensory organ development	BMP6 VAX1 SRF DCHS1 OSR2 VAX2 VSX1 PPP1R13L OLIG2 FOXG1 OTOG	2.45e-04	730	87	11	GO:0007423
GeneOntologyBiologicalProcess	neuron migration	VAX1 CELSR3 SRF NKX6-1 CDK5R2 FOXG1	3.22e-04	218	87	6	GO:0001764
Domain	Cadherin_CS	CELSR3 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 DCHS1 PCDH20	4.95e-08	109	89	8	IPR020894
Domain	CADHERIN_1	CELSR3 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 DCHS1 PCDH20	6.57e-08	113	89	8	PS00232
Domain	Cadherin	CELSR3 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 DCHS1 PCDH20	6.57e-08	113	89	8	PF00028
Domain	CADHERIN_2	CELSR3 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 DCHS1 PCDH20	7.04e-08	114	89	8	PS50268
Domain	-	CELSR3 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 DCHS1 PCDH20	7.04e-08	114	89	8	2.60.40.60
Domain	CA	CELSR3 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 DCHS1 PCDH20	7.53e-08	115	89	8	SM00112
Domain	Cadherin-like	CELSR3 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 DCHS1 PCDH20	8.06e-08	116	89	8	IPR015919
Domain	Cadherin	CELSR3 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 DCHS1 PCDH20	9.21e-08	118	89	8	IPR002126
Domain	Cadherin_2	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 PCDH20	6.51e-07	65	89	6	PF08266
Domain	Cadherin_N	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 PCDH20	6.51e-07	65	89	6	IPR013164
Domain	Cadherin_C	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6	1.62e-06	42	89	5	IPR032455
Domain	Cadherin_C_2	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6	1.62e-06	42	89	5	PF16492
Domain	Post-SET_dom	SETD1B KMT2A	2.58e-03	16	89	2	IPR003616
Domain	PostSET	SETD1B KMT2A	2.58e-03	16	89	2	SM00508
Domain	AT_hook	KMT2A DOT1L	2.58e-03	16	89	2	PF02178
Domain	POST_SET	SETD1B KMT2A	2.58e-03	16	89	2	PS50868
Domain	HTH_motif	VAX1 VAX2 NKX6-1	4.37e-03	69	89	3	IPR000047
Domain	EPHD	KMT2A MLLT6	4.87e-03	22	89	2	PS51805
Domain	-	TBC1D10B PDE3B	4.87e-03	22	89	2	1.10.1300.10
Domain	PDEase_catalytic_dom	TBC1D10B PDE3B	5.32e-03	23	89	2	IPR002073
Domain	EGF_3	CELSR3 MEGF8 HYAL1 LTBP3 OTOG	5.33e-03	235	89	5	PS50026
Domain	EGF	CELSR3 MEGF8 HYAL1 LTBP3 GPR179	5.33e-03	235	89	5	SM00181
Pubmed	Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system.	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6	6.26e-10	17	90	5	18279309
Pubmed	The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6	1.56e-09	20	90	5	11322959
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	CELSR3 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 PCDH20	1.67e-09	80	90	7	10716726
Pubmed	Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems.	PCDHB13 PCDHB12 PCDHB11 PCDHB8	8.70e-09	10	90	4	22969705
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KCTD12 ZNF384 SETD1B CELSR3 MEGF8 TULP4 UBE4B SZT2 PUF60 AHNAK PEX6 AMBRA1 MLLT6 LTBP3 DOT1L SMG6	2.29e-08	1105	90	16	35748872
Pubmed	Protocadherins.	PCDHB13 PCDHB11 PCDHB8 PCDHB6	2.94e-08	13	90	4	12231349
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	CELSR3 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6	3.45e-08	72	90	6	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 PCDH20	4.08e-08	74	90	6	10817752
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6 PCDH20	5.19e-08	77	90	6	10835267
Pubmed	Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle.	VAX1 VAX2 FOXG1	3.33e-07	6	90	3	12223410
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6	3.90e-07	57	90	5	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6	4.26e-07	58	90	5	30377227
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6	9.51e-07	68	90	5	11230163
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	ZNF384 VAX1 SRF OSR2 JDP2 VAX2 VSX1 OLIG2 ATF6B FOXG1	1.51e-06	544	90	10	28473536
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	IRF2BP2 SETD1B PCDHB6 TATDN2 PEX6 KMT2A AMBRA1 DOT1L RAVER1	2.98e-06	457	90	9	32968282
Pubmed	Role of the atypical cadherin Celsr3 during development of the internal capsule.	CELSR3 FOXG1	6.62e-06	2	90	2	19349379
Pubmed	Distinct Responses to Menin Inhibition and Synergy with DOT1L Inhibition in KMT2A-Rearranged Acute Lymphoblastic and Myeloid Leukemia.	KMT2A DOT1L	6.62e-06	2	90	2	38892207
Pubmed	Spinal cord maturation and locomotion in mice with an isolated cortex.	CELSR3 FOXG1	6.62e-06	2	90	2	24012835
Pubmed	SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination.	SRF OLIG2	6.62e-06	2	90	2	38483990
Pubmed	MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.	KMT2A DOT1L	6.62e-06	2	90	2	21741597
Pubmed	DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy.	KMT2A DOT1L	6.62e-06	2	90	2	24858818
Pubmed	Expression of the Vax family homeobox genes suggests multiple roles in eye development.	VAX1 VAX2	6.62e-06	2	90	2	10421837
Pubmed	Characterization of a FOXG1:TLE1 transcriptional network in glioblastoma-initiating cells.	TLE1 FOXG1	6.62e-06	2	90	2	29316219
Pubmed	The role of DOT1L in the maintenance of leukemia gene expression.	KMT2A DOT1L	6.62e-06	2	90	2	27151433
Pubmed	The molecular mechanics of mixed lineage leukemia.	KMT2A DOT1L	6.62e-06	2	90	2	26923329
Pubmed	A role for atypical cadherin Celsr3 in hippocampal maturation and connectivity.	CELSR3 FOXG1	6.62e-06	2	90	2	23035085
Pubmed	Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength.	MEGF8 NKX6-1 OLIG2	7.45e-06	15	90	3	34486668
Pubmed	Multiple roles for Pax2 in the embryonic mouse eye.	VAX1 VAX2 FOXG1	7.45e-06	15	90	3	33428890
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	ABHD17A ATXN2L ZNF384 MEGF8 PUF60 NUP133 LTBP3 PPP1R13L GPR162	1.52e-05	560	90	9	21653829
Pubmed	Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development.	VSX1 OLIG2 FOXG1	1.58e-05	19	90	3	20110327
Pubmed	The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.	NKX6-1 OLIG2 FOXG1	1.58e-05	19	90	3	23332756
Pubmed	A genomic atlas of mouse hypothalamic development.	VAX1 SRF LTBP3 NKX6-1 OLIG2 FOXG1	1.61e-05	205	90	6	20436479
Pubmed	Expanding the clinical and genetic spectrum of Heimler syndrome.	PEX6 PEX26	1.98e-05	3	90	2	31831025
Pubmed	The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes.	PEX6 PEX26	1.98e-05	3	90	2	12717447
Pubmed	Vax1/2 genes counteract Mitf-induced respecification of the retinal pigment epithelium.	VAX1 VAX2	1.98e-05	3	90	2	23555005
Pubmed	Functional interactions between the Forkhead transcription factor FOXK1 and the MADS-box protein SRF.	SRF FOXG1	1.98e-05	3	90	2	17670796
Pubmed	Transducin-like enhancer of Split-1 (TLE1) combines with Forkhead box protein G1 (FoxG1) to promote neuronal survival.	TLE1 FOXG1	1.98e-05	3	90	2	22354967
Pubmed	Detection of OSR2, VAV3, and PPFIA3 Methylation in the Serum of Patients with Gastric Cancer.	OSR2 PPFIA3	1.98e-05	3	90	2	27143812
Pubmed	Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.	KMT2A DOT1L	1.98e-05	3	90	2	23361907
Pubmed	Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p.	PEX6 PEX26	1.98e-05	3	90	2	16854980
Pubmed	AAA peroxins and their recruiter Pex26p modulate the interactions of peroxins involved in peroxisomal protein import.	PEX6 PEX26	1.98e-05	3	90	2	25016021
Pubmed	Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.	KMT2A DOT1L	1.98e-05	3	90	2	28394257
Pubmed	Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond.	KMT2A DOT1L	1.98e-05	3	90	2	26118503
Pubmed	Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.	KMT2A DOT1L	1.98e-05	3	90	2	21398221
Pubmed	A critical role for dorsal progenitors in cortical myelination.	OLIG2 FOXG1	1.98e-05	3	90	2	16436615
Pubmed	Transcription factors FOXG1 and Groucho/TLE promote glioblastoma growth.	TLE1 FOXG1	1.98e-05	3	90	2	24356439
Pubmed	Mutations in the peroxin Pex26p responsible for peroxisome biogenesis disorders of complementation group 8 impair its stability, peroxisomal localization, and interaction with the Pex1p x Pex6p complex.	PEX6 PEX26	1.98e-05	3	90	2	16257970
Pubmed	A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity.	KMT2A DOT1L	1.98e-05	3	90	2	31527241
Pubmed	A census of human transcription factors: function, expression and evolution.	ZNF384 VAX1 SRF JDP2 KMT2A VAX2 NKX6-1 VSX1 OLIG2 ATF6B FOXG1	2.30e-05	908	90	11	19274049
Pubmed	Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning.	BMP6 NKX6-1 OLIG2	2.49e-05	22	90	3	15789444
Pubmed	The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk.	VAX1 CELSR3 FOXG1	3.26e-05	24	90	3	28729440
Pubmed	AF17 facilitates Dot1a nuclear export and upregulates ENaC-mediated Na+ transport in renal collecting duct cells.	MLLT6 DOT1L	3.96e-05	4	90	2	22087315
Pubmed	DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis.	KMT2A DOT1L	3.96e-05	4	90	2	21521783
Pubmed	A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors.	NKX6-1 OLIG2	3.96e-05	4	90	2	26293298
Pubmed	MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.	KMT2A DOT1L	3.96e-05	4	90	2	26927674
Pubmed	AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha.	MLLT6 DOT1L	3.96e-05	4	90	2	19864429
Pubmed	The Celsr3-Kif2a axis directs neuronal migration in the postnatal brain.	CELSR3 FOXG1	3.96e-05	4	90	2	34582949
Pubmed	Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition.	CACNG8 PRRT1	3.96e-05	4	90	2	36429079
Pubmed	Isoform-specific domain organization determines conformation and function of the peroxisomal biogenesis factor PEX26.	PEX6 PEX26	3.96e-05	4	90	2	30366024
Pubmed	AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability.	AMBRA1 PINK1	3.96e-05	4	90	2	34798798
Pubmed	Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.	LRRC32 PCDH20	3.96e-05	4	90	2	21907864
Pubmed	TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.	IRF2BP2 ZNF384 PUF60 NUP133 JDP2	4.86e-05	152	90	5	28192407
Pubmed	The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.	MLLT6 DOT1L	6.59e-05	5	90	2	26439302
Pubmed	Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.	SETD1B KMT2A	6.59e-05	5	90	2	25561738
Pubmed	The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription.	TLE1 FOXG1	6.59e-05	5	90	2	11238932
Pubmed	A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis.	VAX1 VAX2	6.59e-05	5	90	2	10485894
Pubmed	Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex.	NKX6-1 OLIG2	6.59e-05	5	90	2	14573534
Pubmed	[Application of reverse transcription-multiplex nested PCR to detect MLL rearrangement in AML-M4/M5].	KMT2A MLLT6	6.59e-05	5	90	2	16086288
Pubmed	Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides.	TLE1 FOXG1	6.59e-05	5	90	2	18611861
Pubmed	From classical to current: analyzing peripheral nervous system and spinal cord lineage and fate.	NKX6-1 OLIG2	6.59e-05	5	90	2	25446276
Pubmed	Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders.	PEX6 PEX26	6.59e-05	5	90	2	19105186
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	ZNF384 AHNAK KMT2A SMTN	7.57e-05	86	90	4	37253089
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ATXN2L TBC1D10B CRTC3 PDE3B MEGF8 AHNAK MAP3K10 KMT2A NCKAP5L OTOG	7.87e-05	861	90	10	36931259
Pubmed	Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant.	VAX1 VAX2 OLIG2	7.87e-05	32	90	3	36737666
Pubmed	The incidence of T-cell receptor gene rearrangements in childhood B-lineage acute lymphoblastic leukemia is related to immunophenotype and fusion oncogene expression.	ANKS1B KMT2A	9.87e-05	6	90	2	16386788
Pubmed	Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.	KMT2A DOT1L	9.87e-05	6	90	2	21896721
Pubmed	Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal docking and export machinery.	PEX6 PEX26	9.87e-05	6	90	2	30375424
Pubmed	Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2.	NKX6-1 OLIG2	9.87e-05	6	90	2	11567616
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KLHL29 SLC37A1 PDE3B WDR4 TULP4 UBE4B ATXN7L1 FAM53A SRF SRCIN1 SMG6 FAM149A RAVER1	1.18e-04	1489	90	13	28611215
Pubmed	PRC1 sustains the integrity of neural fate in the absence of PRC2 function.	NKX6-1 OLIG2 FOXG1	1.32e-04	38	90	3	34994686
Pubmed	Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo.	NKX6-1 OLIG2	1.38e-04	7	90	2	28926609
Pubmed	Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation.	TLE1 FOXG1	1.38e-04	7	90	2	16314515
Pubmed	HOPX Defines Heterogeneity of Postnatal Subventricular Zone Neural Stem Cells.	SRF OLIG2	1.38e-04	7	90	2	30174314
Pubmed	A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.	LRRC32 ATF6B	1.38e-04	7	90	2	23886662
Pubmed	AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1.	AMBRA1 PINK1	1.38e-04	7	90	2	25215947
Pubmed	Hedgehog-regulated localization of Vax2 controls eye development.	VAX1 VAX2	1.84e-04	8	90	2	17043310
Pubmed	Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma.	VAX1 VAX2	1.84e-04	8	90	2	11830579
Pubmed	A novel mechanism for the transcriptional regulation of Wnt signaling in development.	TLE1 VAX2	1.84e-04	8	90	2	21856776
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	SETD1B KMT2A	1.84e-04	8	90	2	23130995
Pubmed	Expression and function of Nkx6.3 in vertebrate hindbrain.	NKX6-1 OLIG2	1.84e-04	8	90	2	18586225
Pubmed	Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom).	MLLT6 DOT1L	1.84e-04	8	90	2	20203130
Pubmed	TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.	NKX6-1 OLIG2	1.84e-04	8	90	2	36669111
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	SETD1B KMT2A	1.84e-04	8	90	2	22266653
Pubmed	Classification and nomenclature of all human homeobox genes.	VAX1 VAX2	1.84e-04	8	90	2	17963489
Pubmed	Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development.	BMP6 FOXG1	1.84e-04	8	90	2	9187146
Pubmed	ARL13B regulates Sonic hedgehog signaling from outside primary cilia.	NKX6-1 OLIG2	1.84e-04	8	90	2	32129762
Pubmed	Genetic variations strongly influence phenotypic outcome in the mouse retina.	TLE1 VSX1 ABCD2	2.35e-04	46	90	3	21779340
Pubmed	Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.	CELSR3 MEGF8	2.36e-04	9	90	2	9693030
Pubmed	A regulatory network to segregate the identity of neuronal subtypes.	NKX6-1 OLIG2	2.36e-04	9	90	2	18539116
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	SETD1B KMT2A	2.36e-04	9	90	2	22665483
Interaction	PCDHB11 interactions	CELSR3 PCDHB13 PCDHB12 PCDHB11 ATF6B	4.05e-06	56	86	5	int:PCDHB11
Interaction	TLE3 interactions	IRF2BP2 CRTC3 TLE1 OSR2 KMT2A MLLT6 DOT1L VSX1 FOXG1 RAVER1	4.56e-06	376	86	10	int:TLE3
Interaction	PCDHB12 interactions	PCDHB12 PCDHB11 PCDHB6	2.64e-05	14	86	3	int:PCDHB12
Cytoband	5q31	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6	3.35e-06	115	90	5	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6	3.12e-04	298	90	5	chr5q31
Cytoband	2q35	GPBAR1 ANKZF1 CDK5R2	5.17e-04	79	90	3	2q35
Cytoband	8q24.3	SPATC1 PUF60 SLC39A4	1.46e-03	113	90	3	8q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	GPBAR1 ANKZF1 CDK5R2	2.13e-03	129	90	3	chr2q35
GeneFamily	Clustered protocadherins	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB6	3.32e-06	64	65	5	20
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1B KMT2A DOT1L	2.45e-04	34	65	3	487
GeneFamily	AAA ATPases\|Peroxins	PEX6 PEX26	1.48e-03	16	65	2	957
GeneFamily	NKL subclass homeoboxes and pseudogenes	VAX1 VAX2 NKX6-1	1.80e-03	67	65	3	519
Coexpression	MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	BMP6 VAX1 AHNAK SRCIN1 NKX6-1 VSX1 NALF2 CDK5R2 FOXG1	3.33e-06	350	90	9	M1949
Coexpression	MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	BMP6 VAX1 AHNAK SRCIN1 NKX6-1 VSX1 NALF2 CDK5R2 FOXG1	3.91e-06	357	90	9	MM828
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIPRP1 COL20A1 PCDHB12 ANKS1B SRCIN1 PRRT1 IGSF23	8.89e-08	182	90	7	a512863304fad80acaab60a8c6107eb7c9cbac99
Disease	Deafness enamel hypoplasia nail defects	PEX6 PEX26	2.46e-05	3	85	2	C1856186
Disease	Galloway-Mowat syndrome (is_implicated_in)	WDR4 NUP133	8.15e-05	5	85	2	DOID:0080694 (is_implicated_in)
Disease	peroxisomal biogenesis disorder (is_implicated_in)	PEX6 PEX26	2.27e-04	8	85	2	DOID:0080377 (is_implicated_in)
Disease	Galloway Mowat syndrome	WDR4 NUP133	2.27e-04	8	85	2	C0795949
Disease	PEROXISOME BIOGENESIS DISORDER 1A (ZELLWEGER)	PEX6 PEX26	4.44e-04	11	85	2	C4721541
Disease	Amelogenesis Imperfecta	LTBP3 PEX26	5.31e-04	12	85	2	C0002452
Disease	Mitral valve prolapse, response to surgery	LTBP3 SMG6	5.31e-04	12	85	2	EFO_0009951, HP_0001634
Disease	Zellweger Spectrum	PEX6 PEX26	6.27e-04	13	85	2	C3658299
Disease	Infantile Refsum Disease (disorder)	PEX6 PEX26	6.27e-04	13	85	2	C0282527
Disease	Zellweger-Like Syndrome	PEX6 PEX26	6.27e-04	13	85	2	C0751594
Disease	Peroxisome biogenesis disorders	PEX6 PEX26	8.40e-04	15	85	2	C1832200
Disease	Adrenoleukodystrophy, Neonatal	PEX6 PEX26	8.40e-04	15	85	2	C0282525
Disease	Zellweger Syndrome	PEX6 PEX26	9.59e-04	16	85	2	C0043459

Protein segments in the cluster

Peptide	Gene	Start	Entry
ESAPLGPRLLFGSGS	SMG6	426	Q86US8
GPTPLVSGLLAASGL	B3GAT3	116	O94766
LLAGSSTPLLSAGTP	MLLT6	996	P55198
ATSRGASPIGPTLLA	ABCD2	246	Q9UBJ2
APLGTLRASSGAPGR	ABHD17A	51	Q96GS6
TLTGPRLGSPSGKTG	AHNAK	551	Q09666
LSSSPRLGGAAQGPL	DOT1L	1006	Q8TEK3
LSLGPTRRSLGGPLS	AMBRA1	386	Q9C0C7
SLSPASSAKGRRPGG	CDK5R2	6	Q13319
SAKLEPSGRTSLPGG	ATXN7L1	711	Q9ULK2
CSSSRGGRPGLSSLP	ATXN2L	366	Q8WWM7
SSPLGSGEGLLGLSP	RAVER1	511	Q8IY67
LGGGSGPLPLSNLLS	ANKS1B	31	Q7Z6G8
GSTPRTASRKGLPLG	NUP133	26	Q8WUM0
LAPVTLSLSGGDPRG	DCHS1	821	Q96JQ0
LTLTALDGGSPPRSG	PCDHB13	211	Q9Y5F0
GSPPLLGSATLTIGI	PCDH20	296	Q8N6Y1
PGLGLAPSATLVSLS	MAP3K10	736	Q02779
SGSDGSPSPLLARRG	NCKAP5L	491	Q9HCH0
GSRAGTPLGTAPTLL	FAM149A	41	A5PLN7
GSPESRAVGLPLGLS	GPR162	541	Q16538
GGLGEPRMLSPTSTL	GPR179	946	Q6PRD1
LLSPGTPRSLDGSGS	L3MBTL2	71	Q969R5
PLGPGTLLSLLSLGS	GPBAR1	256	Q8TDU6
TGPSPRLGSLGSKAS	HSPB9	141	Q9BQS6
SAAAGALGSPGLPLR	PPFIA3	1156	O75145
VTTGSLPGLGPLTGL	JDP2	11	Q8WYK2
LRPSLPSFTTGLSGG	FOXG1	456	P55316
KSTGLLPGRGPGTSA	PINK1	186	Q9BXM7
GSKTPGLSRITGLDP	PNLIPRP1	181	P54315
PSALRPLLSGLVGGA	PDE3B	241	Q13370
STSAAPLRGLGGPLR	PEX26	6	Q7Z412
PRLQPGGALLTGTSS	PEX6	451	Q13608
GDSPRGPLLASLSGS	MEGF8	91	Q7Z7M0
ALLPVSGGSRLSPSR	NALF2	416	O75949
LSKLSPGLGSPISGL	OSR2	136	Q8N2R0
ILTALDGGSPPRSGT	PCDHB12	211	Q9Y5F1
ILSALDGGSPPRSGT	PCDHB11	211	Q9Y5F2
SSLLRSLGLSPGPGS	P2RY4	6	P51582
SAGGLGPLPRVTSLD	LRRC32	116	Q14392
AALGPLLAGLLSPSG	SLC37A1	476	P57057
GSGGSGPSAILRLPS	CACNG8	251	Q8WXS5
PTLSLSGGSAIGLLA	IGSF23	146	A1L1A6
PRVLSLLSAPLGSGG	ANKZF1	521	Q9H8Y5
GTEPLGSPGTRSKAL	COL20A1	1231	Q9P218
LSPFLGTLNTGGSLP	CRTC3	261	Q6UUV7
PLNRKSLLAPGSGSG	BMP6	181	P22004
PGLSRTGALSTGALP	LTBP3	156	Q9NS15
GGGLTLTTGLNPSLP	KMT2A	3126	Q03164
LTPGGGPLSLRGALS	HYAL1	391	Q12794
GAPRALSTLGSPSLF	DPEP3	41	Q9H4B8
GPLQRGSLSPGALSS	CELSR3	146	Q9NYQ7
SGTATLPRLGAGGLA	PRRT1	51	Q99946
SLLGSGGSAFAPPLR	PPP1R13L	221	Q8WUF5
RSLGSAGPSGTLPRS	PPP1R13L	331	Q8WUF5
ATPLPTALGLGGRAA	IRF2BP2	196	Q7Z5L9
LASRSPSGGAAGPLL	KCTD12	181	Q96CX2
GAEGSGSRSRLSLPP	ARHGAP30	1056	Q7Z6I6
LTLTALDGGSPPRSG	PCDHB8	211	Q9UN66
LIALDGGSPPRSGTS	PCDHB6	211	Q9Y5E3
AAGTAPGLLLGATLP	OTOG	1881	Q6ZRI0
STLLSLGGLPPLTGF	MT-ND2	246	P03891
RLSGSSRGGGPLPLD	SZT2	2746	Q5T011
TRGFLSSGGSPLRPA	TATDN2	106	Q93075
GTLGTPGLVSPALTL	PUF60	346	Q9UHX1
SSPAGLLAGLPRFSS	NKX6-1	151	P78426
TASPPAGLLSLLTSG	SLC39A4	21	Q6P5W5
SLSSGGLPRTPGRDF	SETD1B	1416	Q9UPS6
ASLPGSGLPSVGSIR	OLIG2	241	Q13516
LRLDVSAPGSGGLTP	SOWAHD	176	A6NJG2
SALGGSLNRTPTGRP	SRF	16	P11831
LTGPGLASLLGSSGP	ADRM1	186	Q16186
GPSLDGSSGKALPTR	ATF6B	226	Q99941
PGLDGSSLARGALPL	VSX1	66	Q9NZR4
LPGPGSSATLRLTAT	TULP4	916	Q9NRJ4
PPLGGSAGLLALSSA	TLE1	156	Q04724
SRGPGLVITSPSGSL	ZNF384	116	Q8TF68
LPSGLQSGSPSRSRL	SRCIN1	316	Q9C0H9
AGPLTGTLASSLGLP	SPATC1	146	Q76KD6
SVTPPFGSLRSGGLL	TNS4	171	Q8IZW8
PSSLRISPSLGASGG	UBE4B	391	O95155
LGSTSSLGPGISGPR	TBC1D10B	246	Q4KMP7
GRGSSLSIHSLPSGP	RGS14	36	O43566
LPSPGITGLSHGSNR	TTTY13	41	Q9BZ97
SLPGLPASHRGTSLG	VAX2	206	Q9UIW0
SPGASRALGSLPSGL	ZNF648	116	Q5T619
PGLLLSSSGDGTLRL	WDR4	201	P57081
RGNTPSLSLLRGGDP	ZMYND15	421	Q9H091
GLRAPPTLLSTSSGG	SMTN	491	P53814
ATGALGSALRGPSLP	VAX1	201	Q5SQQ9
SSPTSTPALGGRRGL	FAM53A	241	Q6NSI3
GGTASSLSVRPGLLP	KLHL29	41	Q96CT2