Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase III activity	POLR1C POLR2L	4.76e-04	10	66	2	GO:0001056
GeneOntologyMolecularFunction	RNA polymerase I activity	POLR1C POLR2L	4.76e-04	10	66	2	GO:0001054
GeneOntologyMolecularFunction	UDP-xylosyltransferase activity	RXYLT1 LARGE1	5.81e-04	11	66	2	GO:0035252
GeneOntologyMolecularFunction	xylosyltransferase activity	RXYLT1 LARGE1	5.81e-04	11	66	2	GO:0042285
GeneOntologyCellularComponent	monoatomic ion channel complex	SHISA9 PTK2B KCNG2 KCNG1 STXBP5 KCNJ9 SCN7A	2.05e-04	378	67	7	GO:0034702
Domain	SIM_C	SIM1 SIM2	1.23e-05	2	66	2	IPR010578
Domain	SIM_C	SIM1 SIM2	1.23e-05	2	66	2	PF06621
Domain	SIM_C	SIM1 SIM2	1.23e-05	2	66	2	PS51302
Domain	K_chnl_volt-dep_Kv6	KCNG2 KCNG1	3.68e-05	3	66	2	IPR003969
Domain	HOTDOG_ACOT	ACOT9 ACOT7	7.35e-05	4	66	2	IPR033120
Domain	HOTDOG_ACOT	ACOT9 ACOT7	7.35e-05	4	66	2	PS51770
Domain	Thioestr_dom	ACOT9 ACOT7	2.55e-04	7	66	2	IPR006683
Domain	4HBT	ACOT9 ACOT7	2.55e-04	7	66	2	PF03061
Domain	ARM-like	PPP4R3B PELP1 PKP1 DAXX AGTPBP1 TANGO6	3.79e-04	270	66	6	IPR011989
Domain	HotDog_dom	ACOT9 ACOT7	5.43e-04	10	66	2	IPR029069
Domain	-	ACOT9 ACOT7	5.43e-04	10	66	2	3.10.129.10
Domain	Channel_four-helix_dom	KCNG2 KCNG1 SCN7A	1.08e-03	57	66	3	IPR027359
Domain	-	KCNG2 KCNG1 SCN7A	1.08e-03	57	66	3	1.20.120.350
Domain	ARM-type_fold	FOCAD PPP4R3B PELP1 PKP1 AGTPBP1 TANGO6	1.24e-03	339	66	6	IPR016024
Domain	CONNEXINS_1	GJC3 GJD4	2.02e-03	19	66	2	PS00407
Domain	CONNEXINS_2	GJC3 GJD4	2.24e-03	20	66	2	PS00408
Domain	Connexin	GJC3 GJD4	2.24e-03	20	66	2	IPR000500
Domain	Connexin_CCC	GJC3 GJD4	2.24e-03	20	66	2	IPR019570
Domain	Connexin_N	GJC3 GJD4	2.24e-03	20	66	2	IPR013092
Domain	Connexin	GJC3 GJD4	2.24e-03	20	66	2	PF00029
Domain	Connexin_CCC	GJC3 GJD4	2.24e-03	20	66	2	SM01089
Domain	Connexin_CS	GJC3 GJD4	2.24e-03	20	66	2	IPR017990
Domain	CNX	GJC3 GJD4	2.24e-03	20	66	2	SM00037
Domain	PAS_fold_3	SIM1 SIM2	2.97e-03	23	66	2	IPR013655
Domain	PAS_3	SIM1 SIM2	2.97e-03	23	66	2	PF08447
Domain	PAS-assoc_C	SIM1 SIM2	3.23e-03	24	66	2	IPR000700
Domain	PAS	SIM1 SIM2	3.50e-03	25	66	2	PF00989
Domain	PAS_fold	SIM1 SIM2	3.50e-03	25	66	2	IPR013767
Domain	PAC	SIM1 SIM2	3.78e-03	26	66	2	IPR001610
Domain	PAC	SIM1 SIM2	3.78e-03	26	66	2	SM00086
Domain	PAC	SIM1 SIM2	3.78e-03	26	66	2	PS50113
Domain	K_chnl_volt-dep_Kv	KCNG2 KCNG1	4.08e-03	27	66	2	IPR003968
Domain	DEATH	THOC1 IRAK3	4.08e-03	27	66	2	SM00005
Domain	-	THOC1 IRAK3 CARD10	4.36e-03	93	66	3	1.10.533.10
Domain	DEATH-like_dom	THOC1 IRAK3 CARD10	5.19e-03	99	66	3	IPR011029
Domain	PAS	SIM1 SIM2	5.70e-03	32	66	2	SM00091
Domain	Death	THOC1 IRAK3	6.05e-03	33	66	2	PF00531
Domain	VG_K_chnl	KCNG2 KCNG1	6.05e-03	33	66	2	IPR028325
Domain	PAS	SIM1 SIM2	6.41e-03	34	66	2	IPR000014
Domain	PAS	SIM1 SIM2	6.41e-03	34	66	2	PS50112
Domain	-	SOHLH1 SIM1 SIM2	6.78e-03	109	66	3	4.10.280.10
Pathway	REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_INITIATION_FROM_TYPE_1_PROMOTER	GTF3C1 POLR1C POLR2L	9.61e-05	27	47	3	MM15457
Pathway	REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_INITIATION_FROM_TYPE_1_PROMOTER	GTF3C1 POLR1C POLR2L	1.07e-04	28	47	3	M27716
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_DJ1_TO_FAS_JNK_SIGNALING_PATWHAY	DAXX MAP3K5	1.62e-04	6	47	2	M47712
Pathway	KEGG_MEDICUS_REFERENCE_MANNOSE_TYPE_O_GLYCAN_BIOSYNTHESIS_FKTN_TO_LARGE	RXYLT1 LARGE1	1.62e-04	6	47	2	M47618
Pathway	REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION	GTF3C1 POLR1C POLR2L	1.93e-04	34	47	3	MM15435
Pathway	KEGG_MEDICUS_REFERENCE_FAS_JNK_SIGNALING_PATHWAY	DAXX MAP3K5	2.26e-04	7	47	2	M47711
Pathway	REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION	GTF3C1 POLR1C POLR2L	3.39e-04	41	47	3	M739
Pubmed	Phosphorylation-dependent Lys63-linked polyubiquitination of Daxx is essential for sustained TNF-{alpha}-induced ASK1 activation.	DAXX MAP3K5	3.66e-06	2	67	2	19789334
Pubmed	Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses.	SLC6A8 LYZ	3.66e-06	2	67	2	31399282
Pubmed	Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region.	SIM1 SIM2	3.66e-06	2	67	2	9199934
Pubmed	Single-minded--two genes, three chromosomes.	SIM1 SIM2	3.66e-06	2	67	2	9199929
Pubmed	Overexpression of mSim2 gene in the zona limitans of the diencephalon of segmental trisomy 16 Ts1Cje fetuses, a mouse model for trisomy 21: a novel whole-mount based RNA hybridization study.	SIM1 SIM2	3.66e-06	2	67	2	10837894
Pubmed	A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2.	SIM1 SIM2	3.66e-06	2	67	2	14697214
Pubmed	β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes.	LYZ MAP3K5	3.66e-06	2	67	2	33108364
Pubmed	Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype.	LYZ PCK1	3.66e-06	2	67	2	29317502
Pubmed	A novel mouse model of conditional IRAK-M deficiency in myeloid cells: application in lung Pseudomonas aeruginosa infection.	IRAK3 LYZ	3.66e-06	2	67	2	28120642
Pubmed	Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.	DAXX MAP3K5	3.66e-06	2	67	2	9743501
Pubmed	ASK1 inhibits browning of white adipose tissue in obesity.	LYZ MAP3K5	3.66e-06	2	67	2	32242025
Pubmed	ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets.	LYZ MAP3K5	1.10e-05	3	67	2	28753204
Pubmed	Microspherule protein 2 associates with ASK1 and acts as a negative regulator of stress-induced ASK1 activation.	DAXX MAP3K5	1.10e-05	3	67	2	22609355
Pubmed	Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53.	DAXX MAP3K5	1.10e-05	3	67	2	12482984
Pubmed	Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.	SIM1 SIM2	1.10e-05	3	67	2	24814368
Pubmed	Regulation of osteoclast structure and function by FAK family kinases.	PTK2B LYZ	1.10e-05	3	67	2	22941736
Pubmed	Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology.	SELP LYZ	1.10e-05	3	67	2	37188941
Pubmed	Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12.	PTK2B LYZ	1.10e-05	3	67	2	23589331
Pubmed	Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome.	SIM1 SIM2	1.10e-05	3	67	2	7485157
Pubmed	cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development, and chromosome localization.	SIM1 SIM2	1.10e-05	3	67	2	8561800
Pubmed	Distinct Pathogenesis of Pancreatic Cancer Microvesicle-Associated Venous Thrombosis Identifies New Antithrombotic Targets In Vivo.	SELP LYZ	1.10e-05	3	67	2	29419408
Pubmed	Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm.	DAXX MAP3K5	1.10e-05	3	67	2	11495919
Pubmed	A novel family of katanin-like 2 protein isoforms (KATNAL2), interacting with nucleotide-binding proteins Nubp1 and Nubp2, are key regulators of different MT-based processes in mammalian cells.	KATNAL2 NUBP2	1.10e-05	3	67	2	26153462
Pubmed	Macrophage HIF-1α mediates obesity-related adipose tissue dysfunction via interleukin-1 receptor-associated kinase M.	IRAK3 LYZ	1.10e-05	3	67	2	32154744
Pubmed	Characterization of msim, a murine homologue of the Drosophila sim transcription factor.	SIM1 SIM2	1.10e-05	3	67	2	8661115
Pubmed	Interaction of ARC and Daxx: A Novel Endogenous Target to Preserve Motor Function and Cell Loss after Focal Brain Ischemia in Mice.	DAXX MAP3K5	2.19e-05	4	67	2	27488634
Pubmed	Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities.	VPS28 MAP3K5	2.19e-05	4	67	2	14557248
Pubmed	Sim1 and Sim2 expression during chick and mouse limb development.	SIM1 SIM2	2.19e-05	4	67	2	19123137
Pubmed	Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS.	SIM1 SIM2	2.19e-05	4	67	2	11023872
Pubmed	Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation.	SELP LYZ	2.19e-05	4	67	2	29670076
Pubmed	Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization.	DAXX MAP3K5	2.19e-05	4	67	2	12968034
Pubmed	Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10.	SELP KCNJ9 LYZ	2.96e-05	31	67	3	15921521
Pubmed	Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein.	SIM1 SIM2	3.64e-05	5	67	2	9020169
Pubmed	Inhibition of Daxx-mediated apoptosis by heat shock protein 27.	DAXX MAP3K5	3.64e-05	5	67	2	11003656
Pubmed	Daxx deletion mutant (amino acids 501-625)-induced apoptosis occurs through the JNK/p38-Bax-dependent mitochondrial pathway.	DAXX MAP3K5	3.64e-05	5	67	2	15258908
Pubmed	Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles.	ACOT9 ACOT7	3.64e-05	5	67	2	31676684
Pubmed	Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues.	GJC3 GJD4	5.46e-05	6	67	2	12881038
Pubmed	Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis.	SIM1 SIM2	5.46e-05	6	67	2	8927054
Pubmed	Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.	DAXX MAP3K5	5.46e-05	6	67	2	15983381
Pubmed	The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation.	RXYLT1 LARGE1	5.46e-05	6	67	2	25279699
Pubmed	Neutrophils scan for activated platelets to initiate inflammation.	SELP LYZ	5.46e-05	6	67	2	25477463
Pubmed	A Neutrophil Timer Coordinates Immune Defense and Vascular Protection.	SELP LYZ	5.46e-05	6	67	2	30709741
Pubmed	MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors.	SIM1 SIM2	7.63e-05	7	67	2	27472814
Pubmed	Sim2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus.	SIM1 SIM2	1.02e-04	8	67	2	14988428
Pubmed	Neutrophil ageing is regulated by the microbiome.	SELP LYZ	1.02e-04	8	67	2	26374999
Pubmed	Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors.	SIM1 SIM2	1.02e-04	8	67	2	11782478
Pubmed	Rhythmic modulation of the hematopoietic niche through neutrophil clearance.	SELP LYZ	1.02e-04	8	67	2	23706740
Pubmed	CIIA negatively regulates neuronal cell death induced by oxygen-glucose deprivation and reoxygenation.	VPS28 MAP3K5	1.30e-04	9	67	2	25098452
Pubmed	A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.	ACOT9 ACOT7	1.30e-04	9	67	2	16103133
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FOCAD STXBP5 CSMD3 MARCHF4 AGTPBP1 LARGE1	1.35e-04	407	67	6	12693553
Pubmed	Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants.	SIM1 SIM2	1.63e-04	10	67	2	12024028
Pubmed	Neutrophils instruct homeostatic and pathological states in naive tissues.	SELP LYZ	1.99e-04	11	67	2	30282719
Pubmed	Sim1 and Sim2 are required for the correct targeting of mammillary body axons.	SIM1 SIM2	2.38e-04	12	67	2	16291793
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FOCAD SLC6A8 PCNX3 SH3TC1 KCNG1 ADGRB2 CARD10 MAP3K5 KLHL17	2.61e-04	1105	67	9	35748872
Pubmed	Impact of lactobacilli on orally acquired listeriosis.	CYP2B6 SCN7A PCK1 PYHIN1	2.77e-04	162	67	4	23012479
Pubmed	The murine Otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus.	SIM1 SIM2	2.81e-04	13	67	2	11071765
Pubmed	Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.	SIM1 SIM2	2.81e-04	13	67	2	8812055
Pubmed	FACT facilitates chromatin transcription by RNA polymerases I and III.	POLR1C POLR2L	2.81e-04	13	67	2	19214185
Pubmed	Structure of the human RNA polymerase I elongation complex.	POLR1C POLR2L	2.81e-04	13	67	2	34671025
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	SLC6A8 KATNAL2 CYP2B6 OPN3 IRAK3 ACCSL MARCHF4	3.16e-04	674	67	7	37196079
Pubmed	Evolutionary plasticity of segmentation clock networks.	PPP4R3B LFNG	3.28e-04	14	67	2	21652651
Pubmed	The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans.	POLR1C POLR2L	3.78e-04	15	67	2	36271492
Pubmed	Laminar organization of the early developing anterior hypothalamus.	SIM1 SIM2	4.31e-04	16	67	2	16860307
Pubmed	Structure of human RNA polymerase III elongation complex.	POLR1C POLR2L	4.88e-04	17	67	2	33674783
Pubmed	Structure of human RNA polymerase III.	POLR1C POLR2L	4.88e-04	17	67	2	33335104
Pubmed	The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC.	GTF3C1 POLR2L	4.88e-04	17	67	2	1403646
Pubmed	Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women.	CNTNAP1 IRAK3	4.88e-04	17	67	2	19372141
Pubmed	HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors.	TCEA1 POLR2L	4.88e-04	17	67	2	1559613
Pubmed	Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.	POLR1C POLR2L	4.88e-04	17	67	2	34675218
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	CCDC170 GTF3C1 PCNX3 ST7 HAL DDX27 NUBP2	5.17e-04	732	67	7	34732716
Pubmed	An expression atlas of connexin genes in the mouse.	GJC3 GJD4	5.48e-04	18	67	2	15081111
Pubmed	The novel mouse connexin39 gene is expressed in developing striated muscle fibers.	GJC3 GJD4	5.48e-04	18	67	2	15466892
Pubmed	Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.	POLR1C POLR2L	5.48e-04	18	67	2	12391170
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	GTF3C1 PELP1 POLR2L DAXX DDX27 MAP3K5	5.70e-04	533	67	6	30554943
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	GTF3C1 PELP1 POLR2L TAOK1 DAXX GOLPH3	5.70e-04	533	67	6	25544563
Pubmed	An update on connexin genes and their nomenclature in mouse and man.	GJC3 GJD4	6.12e-04	19	67	2	14681012
Pubmed	Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry.	ADGRB2 MAP3K5	6.12e-04	19	67	2	12543931
Pubmed	Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode.	PELP1 DAXX	6.12e-04	19	67	2	27626385
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	TCEA1 GTF3C1 PELP1 POLR1C DAXX AGTPBP1	6.53e-04	547	67	6	37267103
Pubmed	The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.	HAL PCK1	7.50e-04	21	67	2	27088858
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	PTK2B KCNG1 IRAK3 SIM2 MAP3K5	7.64e-04	372	67	5	22939624
Pubmed	Genome-wide Identification of Foxf2 Target Genes in Palate Development.	CHST2 SIM2	9.01e-04	23	67	2	32040930
Pubmed	Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis.	IRAK3 VPS28	9.01e-04	23	67	2	32597834
Pubmed	DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.	TCEA1 PKP1 LYZ DDX27	1.17e-03	238	67	4	35864588
Pubmed	Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.	THOC1 PKP1 LYZ	1.18e-03	107	67	3	32989256
Pubmed	The DNA sequence and analysis of human chromosome 6.	CCDC170 STXBP5 POLR1C DAXX SIM1 MAP3K5	1.27e-03	622	67	6	14574404
Pubmed	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.	THOC1 TCEA1 DDX27 NUBP2 TANGO6	1.30e-03	419	67	5	28700943
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	GTF3C1 PELP1 SH3TC1 ACOT7 PKP1 SIM2 AGTPBP1	1.30e-03	857	67	7	25609649
Pubmed	Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid.	SIM1 LFNG	1.44e-03	29	67	2	33298461
Pubmed	A genetic approach to Mammalian glycan function.	LFNG LARGE1	1.54e-03	30	67	2	12676797
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	PPP4R3B GTF3C1 PELP1 DAXX DDX27	1.61e-03	440	67	5	34244565
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	TCEA1 PELP1 POLR1C POLR2L DAXX DDX27	1.62e-03	653	67	6	33742100
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	THOC1 GTF3C1 PELP1 ST7 POLR1C CARD10 GOLPH3 LYZ DDX27	1.72e-03	1440	67	9	30833792
Pubmed	T-Cell Signaling in HIV-1 Infection.	PTK2B MAP3K5	1.75e-03	32	67	2	23986795
Pubmed	The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor.	TCEA1 POLR2L	1.86e-03	33	67	2	9765201
Pubmed	The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.	PKP1 DDX27	1.86e-03	33	67	2	26296893
Pubmed	The RNA polymerase II elongation complex.	TCEA1 POLR2L	1.86e-03	33	67	2	12676794
Cytoband	Ensembl 112 genes in cytogenetic band chr12q14	CYP27B1 IRAK3 RXYLT1	6.53e-04	115	67	3	chr12q14
GeneFamily	Acyl-CoA thioesterases	ACOT9 ACOT7	3.06e-04	10	48	2	41
GeneFamily	Gap junction proteins	GJC3 GJD4	1.54e-03	22	48	2	314
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	TAOK1 MAP3K5	1.84e-03	24	48	2	654
GeneFamily	General transcription factors\|Xeroderma pigmentosum complementation groups\|DNA helicases\|ERCC excision repair associated	TCEA1 GTF3C1	1.99e-03	25	48	2	565
GeneFamily	RNA polymerase subunits	POLR1C POLR2L	2.68e-03	29	48	2	726
GeneFamily	Basic helix-loop-helix proteins	SOHLH1 SIM1 SIM2	3.11e-03	110	48	3	420
GeneFamily	Potassium voltage-gated channels	KCNG2 KCNG1	5.05e-03	40	48	2	274
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELP CSMD3	1.00e-02	57	48	2	1179
ToppCell	COPD-Myeloid-ncMonocyte\|COPD / Disease state, Lineage and Cell class	PTK2B SH3TC1 ACOT9 SLC49A4 IRAK3 AGTPBP1	4.63e-07	193	67	6	936ca95995599356b794fba32bfd82d8de339365
ToppCell	PND07-28-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ACER2 ADCY4 SCN7A CARD10 TANGO6	7.87e-06	181	67	5	9cd5e5c285c2b628db9d59709af053defd7c0aff
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SELP ADCY4 SH3TC1 CARD10 LFNG	9.21e-06	187	67	5	03de3c2df31bca0dc4e3718bada708d8fe8b69b9
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTK2B IRAK3 HAL LYZ AGTPBP1	9.70e-06	189	67	5	55aba1ebc012006a5db3ff9c92589cb3d9f7c68a
Disease	unipolar depression	CCDC170 SHISA9 KCNG2 KCNG1 KCNJ9 CNTNAP1 SIM1 CSMD3 MAP3K5 LARGE1	2.90e-04	1206	65	10	EFO_0003761
Disease	MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2K	RXYLT1 LARGE1	4.27e-04	14	65	2	C1836373
Disease	alpha-Dystroglycanopathies	RXYLT1 LARGE1	4.27e-04	14	65	2	C2936406
Disease	Muscle eye brain disease	RXYLT1 LARGE1	4.27e-04	14	65	2	C0457133
Disease	Fukuyama Type Congenital Muscular Dystrophy	RXYLT1 LARGE1	4.27e-04	14	65	2	C0410174
Disease	Muscular Dystrophy-Dystroglycanopathy (Congenital with Brain and Eye Anomalies) Type A, 1	RXYLT1 LARGE1	4.27e-04	14	65	2	C4284790
Disease	Walker-Warburg congenital muscular dystrophy	RXYLT1 LARGE1	4.93e-04	15	65	2	C0265221
Disease	Intellectual Disability	SLC6A8 ACOT9 NUDT2 TAOK1 LARGE1	3.06e-03	447	65	5	C3714756
Disease	volumetric bone mineral density	CCDC170 PTK2B	3.89e-03	42	65	2	EFO_0007620

Protein segments in the cluster

Peptide	Gene	Start	Entry
LPRLKLAMRRFCDVL	ACCSL	536	Q4AC99
MKLLARALRLCEFGR	ACOT7	1	O00154
IGRMRTRLVRKRFLC	ADGRB2	1026	O60241
NRTGRLMDILRCRGK	CARD10	76	Q9BWT7
ELKRRPFVGCLRAMR	CNTNAP1	921	P78357
MDRRGLLKSFLRFRE	CYP2B6	46	P20813
KRRCAKCGRLDFILM	CSMD3	21	Q7Z407
LKRCDNMRVFKLGLF	ACER2	166	Q5QJU3
MRRAALRLCALGKGQ	ACOT9	1	Q9Y305
LDMCRAIRKLRAATG	ADCY4	346	Q8NFM4
MALRACGLIIFRRCL	NUDT2	1	P50583
MGAKFCVGLLRLKRL	AGTPBP1	1126	Q9UPW5
ARLKRKLIRLFGRLC	DAXX	226	Q9UER7
MVLAQRRRGGCEKLR	DDX27	1	Q96GQ7
RRELTFCRKTGLRVM	NUBP2	171	Q9Y5Y2
LGKKCFALRMASRLA	PCK1	241	P35558
LRDGRLCLMFRVGDL	KCNJ9	181	Q92806
GKRSCMGRRLAELEL	CYP27B1	451	O15528
MCGRFLRRLLAEESR	GJC3	1	Q8NFK1
MLGICRGRRKFLAAS	LARGE1	1	O95461
MLKRCGRRLLLALAG	LFNG	1	Q8NES3
ILKRAREFMELLFGL	MAGEC2	181	Q9UBF1
FERCELARTLKRLGM	LYZ	21	P61626
LGLADLVCSLRRRMR	GJD4	211	Q96KN9
CRALLMTVAGLKLLR	PCNX3	1176	Q9H6A9
LGLTMRRCAREFGLL	KCNG2	311	Q9UJ96
LDCAMLRRLEKRILV	KATNAL2	406	Q8IYT4
LRAGKLRLLREMCAL	KCNG1	131	Q9UIX4
LLRELMEKRGLDSCL	IRAK3	386	Q9Y616
LALCALRFMRRIIGL	PPP4R3B	586	Q5MIZ7
LRQRFSGLARCLGLM	PELP1	311	Q8IZL8
FMIRKFRRSLLQLLC	OPN3	311	Q9H1Y3
RCRMLLALRINVLAK	HAL	206	P42357
RLMKCVRLPLLSRDF	KLHL17	276	Q6TDP4
ARFADFIRGMLKLIL	SLC49A4	336	Q96SL1
KLRLFCFRLRKRENM	PYHIN1	371	Q6K0P9
GRLQLEACGMRRKSL	GOLPH3	101	Q9H4A6
RCRMLFNDLKVFLLR	MARCHF4	41	Q9P2E8
IMGGTLLALLRKRFR	SELP	786	P16109
FREKIAALLRGRLSM	CCDC170	326	Q8IYT3
LQLGCLELRRFFKDM	PTK2B	176	Q14289
MRLTRKRLCSFLIAL	RXYLT1	1	Q9Y2B1
LALGMFLSRLCEEKL	FOCAD	1091	Q5VW36
RMFRVRNCLRGLGLF	nan	866	A6NNC1
RDDLKCLRLRGGMLC	MAP3K5	1346	Q99683
ATGCLRKRLGMRELL	PKP1	406	Q13835
RKRMSLSCERLRALL	SOHLH1	66	Q5JUK2
RKACSLLRLRMREEL	TEDC2	271	Q7L2K0
FLRMKCVLAKRNAGL	SIM2	161	Q14190
FLRMKCVLAKRNAGL	SIM1	161	P81133
MRRVLRLLLGCFLTE	SHISA9	1	B4DS77
LELECRRFKRRMLLG	TAOK1	611	Q7L7X3
KKAGLLMALARLCFL	SH3TC1	551	Q8TE82
RLKCREMLAAALRTG	TCEA1	141	P23193
LLGCLLRAKGTMAER	SLC6A8	576	P48029
IKVLMGKCRRFLDEL	POLR1C	326	O15160
VYIKRRLAMCARRLG	ST7	296	Q9NRC1
ILRLKGAILRMAFLD	STXBP5	851	Q5T5C0
LGMKVFRRKALVLCA	CHST2	46	Q9Y4C5
LLLAKVMRFERFGRR	CNBD2	126	Q96M20
RCLEEIRGLRKKFRA	TCEAL7	71	Q9BRU2
CRKFRLDCPLAMERI	VPS28	96	Q9UK41
LRRLCGQLLSERLMR	TANGO6	301	Q9C0B7
TFLFERVLLRMLGCR	SMCO2	306	A6NFE2
DALGLKRYCCRRMLL	POLR2L	36	P62875
GMALLRLFRMLRIFK	SCN7A	591	Q01118
GKLEARMLCRLLQRF	GTF3C1	396	Q12789
RMLCRLLQRFKVVKG	GTF3C1	401	Q12789
LLRMCNDLLRRLSKS	THOC1	136	Q96FV9