Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	NAD(P)H oxidase H2O2-forming activity	DUOX1 NOX1 DUOX2	1.83e-05	12	89	3	GO:0016174
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	DUOX1 NOX1 DUOX2	1.83e-05	12	89	3	GO:0016175
GeneOntologyMolecularFunction	NADH oxidase H202-forming activity	DUOX1 DUOX2	1.96e-05	2	89	2	GO:0106293
GeneOntologyMolecularFunction	fructose-bisphosphate aldolase activity	ALDOB ALDOC	5.88e-05	3	89	2	GO:0004332
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	DUOX1 NOX1 DUOX2	9.24e-05	20	89	3	GO:0050664
GeneOntologyMolecularFunction	carbon-carbon lyase activity	ALDOB ALDOC GOT1 CRY1	1.13e-04	56	89	4	GO:0016830
GeneOntologyMolecularFunction	NADPH oxidase H202-forming activity	DUOX1 DUOX2	1.95e-04	5	89	2	GO:0106294
GeneOntologyMolecularFunction	pre-mRNA 3'-splice site binding	ZRSR2P1 ZRSR2	4.07e-04	7	89	2	GO:0030628
GeneOntologyMolecularFunction	antioxidant activity	DUOX1 HPR DUOX2 SOD3	9.32e-04	97	89	4	GO:0016209
GeneOntologyMolecularFunction	ADP transmembrane transporter activity	SLC25A42 SLC25A5	1.05e-03	11	89	2	GO:0015217
GeneOntologyMolecularFunction	aldehyde-lyase activity	ALDOB ALDOC	1.05e-03	11	89	2	GO:0016832
GeneOntologyBiologicalProcess	blood coagulation, common pathway	THBD FGA	1.76e-05	2	87	2	GO:0072377
GeneOntologyCellularComponent	NADPH oxidase complex	DUOX1 NOX1 DUOX2	5.62e-05	18	88	3	GO:0043020
GeneOntologyCellularComponent	mitochondrial permeability transition pore complex	SLC25A5 BAX	3.63e-04	7	88	2	GO:0005757
GeneOntologyCellularComponent	U2AF complex	ZRSR2P1 ZRSR2	3.63e-04	7	88	2	GO:0089701
GeneOntologyCellularComponent	fibrinogen complex	FGA FGL2	4.83e-04	8	88	2	GO:0005577
Domain	NAD_binding_6	DUOX1 NOX1 DUOX2	3.26e-06	7	86	3	PF08030
Domain	FAD_binding_8	DUOX1 NOX1 DUOX2	3.26e-06	7	86	3	PF08022
Domain	FAD-bd_8	DUOX1 NOX1 DUOX2	3.26e-06	7	86	3	IPR013112
Domain	Fe_red_NAD-bd_6	DUOX1 NOX1 DUOX2	3.26e-06	7	86	3	IPR013121
Domain	Ferric_reduct	DUOX1 NOX1 DUOX2	2.01e-05	12	86	3	PF01794
Domain	Fe3_Rdtase_TM_dom	DUOX1 NOX1 DUOX2	2.01e-05	12	86	3	IPR013130
Domain	LIMR	LMBR1L LMBR1	2.10e-05	2	86	2	IPR008075
Domain	DUOX1	DUOX1 DUOX2	2.10e-05	2	86	2	IPR029595
Domain	FBA_I	ALDOB ALDOC	6.27e-05	3	86	2	IPR000741
Domain	Glycolytic	ALDOB ALDOC	6.27e-05	3	86	2	PF00274
Domain	Aldolase_I_AS	ALDOB ALDOC	6.27e-05	3	86	2	IPR029768
Domain	ALDOLASE_CLASS_I	ALDOB ALDOC	6.27e-05	3	86	2	PS00158
Domain	Fd_Rdtase_FAD-bd	DUOX1 NOX1 DUOX2	8.66e-05	19	86	3	IPR017927
Domain	FAD_FR	DUOX1 NOX1 DUOX2	8.66e-05	19	86	3	PS51384
Domain	Riboflavin_synthase-like_b-brl	DUOX1 NOX1 DUOX2	8.66e-05	19	86	3	IPR017938
Domain	LMBR1	LMBR1L LMBR1	1.25e-04	4	86	2	PF04791
Domain	LMBR1-like_membr_prot	LMBR1L LMBR1	1.25e-04	4	86	2	IPR006876
Domain	U2AF_small	ZRSR2P1 ZRSR2	2.08e-04	5	86	2	IPR009145
Domain	Haem_peroxidase	DUOX1 DUOX2	9.21e-04	10	86	2	IPR010255
Domain	An_peroxidase	DUOX1 DUOX2	9.21e-04	10	86	2	PF03098
Domain	PEROXIDASE_3	DUOX1 DUOX2	9.21e-04	10	86	2	PS50292
Domain	Haem_peroxidase_animal	DUOX1 DUOX2	9.21e-04	10	86	2	IPR019791
Domain	-	DUOX1 DUOX2	9.21e-04	10	86	2	1.10.640.10
Domain	-	RSAD2 ALDOB ALDOC	9.50e-04	42	86	3	3.20.20.70
Domain	Aldolase_TIM	RSAD2 ALDOB ALDOC	1.09e-03	44	86	3	IPR013785
Domain	EGF_CA	THBD MASP1 CELSR1 FAT2	2.44e-03	122	86	4	SM00179
Domain	EGF-like_Ca-bd_dom	THBD MASP1 CELSR1 FAT2	2.58e-03	124	86	4	IPR001881
Domain	Fibrinogen_CS	FGA FGL2	3.41e-03	19	86	2	IPR020837
Domain	AA-permease/SLC12A_dom	SLC7A4 SLC12A7	4.56e-03	22	86	2	IPR004841
Domain	AA_permease	SLC7A4 SLC12A7	4.56e-03	22	86	2	PF00324
Domain	-	GLB1L3 HECTD1 F5	4.65e-03	73	86	3	2.60.120.260
Domain	Fibrinogen_a/b/g_C_2	FGA FGL2	5.42e-03	24	86	2	IPR014715
Domain	-	FGA FGL2	5.42e-03	24	86	2	4.10.530.10
Pathway	WP_METABOLIC_EPILEPTIC_DISORDERS	SLC25A5 GCDH ALDOB ALDOC GOT1	7.07e-05	91	67	5	M48079
Pathway	REACTOME_COMMON_PATHWAY_OF_FIBRIN_CLOT_FORMATION	THBD FGA F5	1.48e-04	22	67	3	M17879
Pathway	REACTOME_COMMON_PATHWAY_OF_FIBRIN_CLOT_FORMATION	THBD FGA F5	1.48e-04	22	67	3	MM14558
Pubmed	Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation.	DUOX1 NOX1 DUOX2	1.61e-07	5	89	3	34784249
Pubmed	APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury.	DUOX1 NOX1 DUOX2	3.22e-07	6	89	3	28165467
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	FAT2 DPEP2 AOC3 FGA PZP F5 SOD3 FGL2	3.36e-07	257	89	8	16335952
Pubmed	Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase.	DUOX1 NOX1 DUOX2	5.63e-07	7	89	3	19005069
Pubmed	Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO.	DUOX1 NOX1 DUOX2	2.63e-06	11	89	3	30755476
Pubmed	Large-scale identification of mammalian proteins localized to nuclear sub-compartments.	ZRSR2P1 ZRSR2 NR3C1 CRY1	2.77e-06	38	89	4	11555636
Pubmed	Gene variants associated with venous thrombosis: confirmation in the MEGA study.	THBD FGA F5	3.50e-06	12	89	3	20128871
Pubmed	Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.	THBD DUOX1 NOX1 BAX DUOX2	4.49e-06	94	89	5	20346360
Pubmed	Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism.	DUOX1 DUOX2	6.48e-06	2	89	2	28633507
Pubmed	ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.	ZRSR2P1 ZRSR2	6.48e-06	2	89	2	33691379
Pubmed	Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family.	FOXO3 FOXO3B	6.48e-06	2	89	2	9852958
Pubmed	Reactive oxygen species regulate the levels of dual oxidase (Duox1-2) in human neuroblastoma cells.	DUOX1 DUOX2	6.48e-06	2	89	2	22523549
Pubmed	Expression of dual oxidases and secreted cytokines in chronic rhinosinusitis.	DUOX1 DUOX2	6.48e-06	2	89	2	23281318
Pubmed	Dual oxidase 1 and NADPH oxidase 2 exert favorable effects in cervical cancer patients by activating immune response.	DUOX1 DUOX2	6.48e-06	2	89	2	31706280
Pubmed	Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.	DUOX1 DUOX2	6.48e-06	2	89	2	15972824
Pubmed	Conserved cysteine residues provide a protein-protein interaction surface in dual oxidase (DUOX) proteins.	DUOX1 DUOX2	6.48e-06	2	89	2	23362256
Pubmed	Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.	DUOX1 DUOX2	6.48e-06	2	89	2	19144650
Pubmed	Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas.	DUOX1 DUOX2	6.48e-06	2	89	2	11762710
Pubmed	Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.	DUOX1 DUOX2	6.48e-06	2	89	2	11822874
Pubmed	Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium.	NOX1 DUOX2	6.48e-06	2	89	2	27930931
Pubmed	Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease.	DUOX1 DUOX2	6.48e-06	2	89	2	18177232
Pubmed	Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense.	DUOX1 DUOX2	6.48e-06	2	89	2	12824283
Pubmed	Congenital Hypothyroidism due to Oligogenic Mutations in Two Sudanese Families.	DUOX1 DUOX2	6.48e-06	2	89	2	30375286
Pubmed	The NOD2 p.Leu1007fsX1008 mutation (rs2066847) is a stronger predictor of the clinical course of Crohn's disease than the FOXO3A intron variant rs12212067.	FOXO3 NOD2	6.48e-06	2	89	2	25365249
Pubmed	Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.	DUOX1 DUOX2	6.48e-06	2	89	2	10806195
Pubmed	Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.	DUOX1 DUOX2	6.48e-06	2	89	2	11514595
Pubmed	Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B.	FOXO3 FOXO3B	6.48e-06	2	89	2	22588664
Pubmed	Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling.	DUOX1 DUOX2	6.48e-06	2	89	2	24161126
Pubmed	Increased NOX1 and DUOX2 expression in the colonic mucosa of patients with chronic functional constipation.	NOX1 DUOX2	6.48e-06	2	89	2	35960091
Pubmed	Hepatitis C virus entry is impaired by claudin-1 downregulation in diacylglycerol acyltransferase-1-deficient cells.	CLDN1 DGAT1	6.48e-06	2	89	2	24899196
Pubmed	Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues.	DUOX1 DUOX2	6.48e-06	2	89	2	11443211
Pubmed	Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas.	DUOX1 DUOX2	6.48e-06	2	89	2	10601291
Pubmed	Elimination of aberrant DRG circuitries in Sema3A mutant mice leads to extensive neuronal deficits.	SEMA3A BAX	6.48e-06	2	89	2	23922915
Pubmed	Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development.	ZRSR2P1 ZRSR2	6.48e-06	2	89	2	35198906
Pubmed	The extracellular A-loop of dual oxidases affects the specificity of reactive oxygen species release.	DUOX1 DUOX2	6.48e-06	2	89	2	25586178
Pubmed	Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.	DUOX1 DUOX2	6.48e-06	2	89	2	16111680
Pubmed	Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases.	DUOX1 DUOX2	6.48e-06	2	89	2	11753072
Pubmed	Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer.	DUOX1 DUOX2	6.48e-06	2	89	2	18281478
Pubmed	Structural and functional characterization of the two human ThOX/Duox genes and their 5'-flanking regions.	DUOX1 DUOX2	6.48e-06	2	89	2	15062544
Pubmed	Regulated hydrogen peroxide production by Duox in human airway epithelial cells.	DUOX1 DUOX2	6.48e-06	2	89	2	15677770
Pubmed	Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate.	BAX NR3C1	6.48e-06	2	89	2	10744634
Pubmed	Mucosal reactive oxygen species are required for antiviral response: role of Duox in influenza a virus infection.	DUOX1 DUOX2	6.48e-06	2	89	2	24128054
Pubmed	DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses.	DUOX2 NOD2	6.48e-06	2	89	2	19759286
Pubmed	Cause-effect relation between hyperfibrinogenemia and vascular disease.	THBD FGA	6.48e-06	2	89	2	14615369
Pubmed	Mode of interactions of human aldolase isozymes with cytoskeletons.	ALDOB ALDOC	1.94e-05	3	89	2	9244396
Pubmed	Aldolase positively regulates of the canonical Wnt signaling pathway.	ALDOB ALDOC	1.94e-05	3	89	2	24993527
Pubmed	Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism.	LMBR1L LMBR1	1.94e-05	3	89	2	19136951
Pubmed	Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1.	ZRSR2P1 ZRSR2	1.94e-05	3	89	2	8586425
Pubmed	NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy.	DUOX1 DUOX2	1.94e-05	3	89	2	21915726
Pubmed	Fibrinogen alpha and gamma genes and factor VLeiden in children with thromboembolism: results from 2 family-based association studies.	FGA F5	1.94e-05	3	89	2	19515723
Pubmed	A splice junction-targeted CRISPR approach (spJCRISPR) reveals human FOXO3B to be a protein-coding gene.	FOXO3 FOXO3B	1.94e-05	3	89	2	29925039
Pubmed	LMBRD1: the gene for the cblF defect of vitamin B₁₂ metabolism.	LMBR1L LMBR1	1.94e-05	3	89	2	20446115
Pubmed	NADPH oxidase-dependent acid production in airway epithelial cells.	DUOX1 DUOX2	1.94e-05	3	89	2	15210697
Pubmed	Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.	ZRSR2P1 ZRSR2	1.94e-05	3	89	2	36030305
Pubmed	Thrombomodulin-dependent effect of factor VLeiden mutation on factor XIII activation.	THBD F5	1.94e-05	3	89	2	21774968
Pubmed	Haemostatic gene polymorphisms in young indian asian subjects with acute myocardial infarction.	THBD F5	1.94e-05	3	89	2	14523329
Pubmed	Role of nicotinamide adenine dinucleotide phosphate oxidase in mediating vesicant-induced interleukin-6 secretion in human airway epithelial cells.	DUOX1 DUOX2	1.94e-05	3	89	2	24164541
Pubmed	DUOX enzyme activity promotes AKT signalling in prostate cancer cells.	DUOX1 DUOX2	1.94e-05	3	89	2	23225414
Pubmed	FOXO3 is a glucocorticoid receptor target and regulates LKB1 and its own expression based on cellular AMP levels via a positive autoregulatory loop.	FOXO3 NR3C1	1.94e-05	3	89	2	22848740
Pubmed	Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments.	ALDOB ALDOC	1.94e-05	3	89	2	6696436
Pubmed	Paraoxonase 2 (PON2) decreases high glucose-induced macrophage triglycerides (TG) accumulation, via inhibition of NADPH-oxidase and DGAT1 activity: studies in PON2-deficient mice.	NOX1 DGAT1	1.94e-05	3	89	2	19748094
Pubmed	Reduced thrombin generation increases host susceptibility to group A streptococcal infection.	FGA F5	1.94e-05	3	89	2	19056689
Pubmed	Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn's Disease Patients.	MASP1 NOD2	1.94e-05	3	89	2	27404661
Pubmed	Association of duoxes with thyroid peroxidase and its regulation in thyrocytes.	DUOX1 DUOX2	1.94e-05	3	89	2	19952225
Pubmed	Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen.	THBD FGA F5	2.41e-05	22	89	3	12871600
Pubmed	Characterization of single-nucleotide polymorphisms in coding regions of human genes.	CYP11A1 FGA NR3C1 F5	2.71e-05	67	89	4	10391209
Pubmed	Integrative predictive model of coronary artery calcification in atherosclerosis.	THBD OLFML2B FGA NR3C1 F5 SOD3	2.81e-05	229	89	6	19948975
Pubmed	Semaphorin 3A upregulates FOXO 3a-dependent MelCAM expression leading to attenuation of breast tumor growth and angiogenesis.	SEMA3A FOXO3	3.87e-05	4	89	2	24727891
Pubmed	The prevalence of inherited thrombophilic polymorphisms in an asymptomatic Australian antenatal population.	THBD F5	3.87e-05	4	89	2	19133039
Pubmed	Mouse U2af1-rs1 is a neomorphic imprinted gene.	ZRSR2P1 ZRSR2	3.87e-05	4	89	2	9001233
Pubmed	The thrombomodulin-protein C system is essential for the maintenance of pregnancy.	THBD FGA	3.87e-05	4	89	2	12579195
Pubmed	FOXO3A directs a protective autophagy program in haematopoietic stem cells.	FOXO3 BAX	3.87e-05	4	89	2	23389440
Pubmed	Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders.	CYP11A1 NR3C1	3.87e-05	4	89	2	30824750
Pubmed	The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA.	DUOX1 DUOX2	3.87e-05	4	89	2	22814254
Pubmed	Cloning and mapping of the U2af1-rs2 gene with a high transmission distortion in interspecific backcross progeny.	ZRSR2P1 ZRSR2	3.87e-05	4	89	2	7558001
Pubmed	The roles of protein C and thrombomodulin in the regulation of blood coagulation.	THBD F5	3.87e-05	4	89	2	2538457
Pubmed	Ethnic differences in the prevalence of inherited thrombophilic polymorphisms in an asymptomatic Australian prenatal population.	THBD F5	3.87e-05	4	89	2	17278618
Pubmed	Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF.	DUOX1 DUOX2	3.87e-05	4	89	2	27110716
Pubmed	Fibrinogen Aalpha-Thr312Ala and factor XIII-A Val34Leu polymorphisms in idiopathic venous thromboembolism.	FGA F5	3.87e-05	4	89	2	17568659
Pubmed	Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.	DUOX1 DUOX2	3.87e-05	4	89	2	19339556
Pubmed	Combined effects of thrombosis pathway gene variants predict cardiovascular events.	THBD F5	3.87e-05	4	89	2	17677000
Pubmed	Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.	FOXO3 FOXO3B	3.87e-05	4	89	2	9479491
Pubmed	Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump.	ALDOB ALDOC	3.87e-05	4	89	2	11399750
Pubmed	Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.	XYLT1 DUOX1 DUOX2	4.04e-05	26	89	3	33905568
Pubmed	Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers.	THBD F5	6.44e-05	5	89	2	17438064
Pubmed	Factor XIII Val34Leu polymorphism and ischaemic stroke in patients with patent foramen ovale.	FGA F5	6.44e-05	5	89	2	19967163
Pubmed	Expression of TPO and ThOXs in human thyrocytes is downregulated by IL-1alpha/IFN-gamma, an effect partially mediated by nitric oxide.	DUOX1 DUOX2	6.44e-05	5	89	2	16478776
Pubmed	Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis.	NOX1 DUOX2	6.44e-05	5	89	2	33127391
Pubmed	Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability.	THBD F5	6.44e-05	5	89	2	19687358
Pubmed	Heparin rescues factor V Leiden-associated placental failure independent of anticoagulation in a murine high-risk pregnancy model.	THBD F5	6.44e-05	5	89	2	23325830
Pubmed	Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.	FOXO3 BAX	6.44e-05	5	89	2	24493802
Pubmed	Identification of a novel partner of duox: EFP1, a thioredoxin-related protein.	DUOX1 DUOX2	6.44e-05	5	89	2	15561711
Pubmed	Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment.	CYP11A1 NR3C1	6.44e-05	5	89	2	32937153
Pubmed	The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA-/VacA- H. pylori.	NOX1 DUOX2	6.44e-05	5	89	2	27048452
Pubmed	Early embryonic expression of murine coagulation system components.	THBD FGA F5	9.15e-05	34	89	3	11154109
Pubmed	Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult.	DUOX1 DUOX2	9.65e-05	6	89	2	17332529
Pubmed	[Pharmacogenetics of the local thrombolysis in patients with deep vein thrombosis].	FGA F5	9.65e-05	6	89	2	16466010
Pubmed	The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore.	SLC25A5 BAX	9.65e-05	6	89	2	10620603
Pubmed	Haemostatic genetic variants, ABO blood group and bleeding risk during oral anticoagulant treatment after cerebral ischaemia of arterial origin.	FGA F5	9.65e-05	6	89	2	17994314
Pubmed	The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast cancer.	FOXO3 FOXQ1	9.65e-05	6	89	2	38608123
GeneFamily	Solute carriers	SLC7A4 SLC25A42 SLC25A5 SLC22A13 SLC12A7 SLC27A3	1.23e-03	395	55	6	752
GeneFamily	Fibrinogen C domain containing	FGA FGL2	2.61e-03	25	55	2	554
GeneFamily	Zinc fingers CCCH-type	ZRSR2P1 ZRSR2	5.07e-03	35	55	2	73
GeneFamily	Potassium voltage-gated channels	KCNH2 KCNQ2	6.58e-03	40	55	2	274
GeneFamily	Forkhead boxes	FOXO3 FOXQ1	7.57e-03	43	55	2	508
ToppCell	facs-Kidney-nan-18m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAG FOXQ1 SLC22A13 GCDH ALDOB SOD3	1.51e-06	177	89	6	7f58286fc8797e9bdcf8ece0849f55680905955d
ToppCell	facs-Kidney-nan-18m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAG FOXQ1 SLC22A13 GCDH ALDOB SOD3	1.51e-06	177	89	6	d4cd54c07f1e51b5485270348fb7195d53465027
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-double_negative_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR83 KDM5B SLC25A5 LRP10 NFKBID GOT1	2.28e-06	190	89	6	84265be128170cbb08d76e824aa108e07da9c3e5
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_activated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC25A5 DPEP2 OLFML2B KMT5C NFKBID FGL2	2.97e-06	199	89	6	6dc446a5d183b01bdf227e45bd88d0b3d8b1c56a
ToppCell	E18.5-samps-Mesenchymal-Pericyte-pericyte_D\|E18.5-samps / Age Group, Lineage, Cell class and subclass	TRAPPC11 SERGEF AOC3 ALDH18A1 SOD3	1.24e-05	149	89	5	dcf68eb25733b5db2893728fe4dca5c7267eb58c
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MASP1 FAT2 GCDH FGF14 HIF3A	1.40e-05	153	89	5	1524557514668f515ac1bbe847611f564b265b42
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	THBD FAT2 CPZ HIF3A SLC12A7	1.40e-05	153	89	5	151c469b26f9adf04dd6f117f03bef760cc3d45d
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KCNH2 SERGEF KCNQ2 GCDH FGL2	1.50e-05	155	89	5	b5d5c38b269e9318970fcce564df1c8ed7a7ccc6
ToppCell	PND03-Immune-Immune_Myeloid-Granulocytic\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RSAD2 CYP11A1 NFKBID APBB1IP FGL2	1.50e-05	155	89	5	3f31f3c37eb40d5467def8506e349fa4b4695833
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	THBD RSAD2 AOC3 DNAAF11 FGL2	1.54e-05	156	89	5	f5889a6899904dfb7f596600b3a76857cf9d5378
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O1-Trf\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CRYBG2 FAT2 TSPAN10 DPEP2	1.65e-05	76	89	4	efbbbf91bca35720d8ecddb076f2c9f4de25e44d
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O1\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CRYBG2 FAT2 TSPAN10 DPEP2	1.65e-05	76	89	4	254d18bece2676faa4bbeb8d48b1d327ab3c2215
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DUOX1 CELSR1 DPY19L2 FGF14 POMT1	2.40e-05	171	89	5	1854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A DNAH10 UGGT2 SMOX FGL2	2.68e-05	175	89	5	0801cccec6915aefc135262fc74580280fd51aa5
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A DNAH10 UGGT2 SMOX FGL2	2.68e-05	175	89	5	09163e7030f76d706eccabdb1d5ec45f8412aa75
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAG DNAH10 SLC25A5 KIF12 DNAAF11	2.91e-05	178	89	5	58857bb8c13e0e1c6d9f5c1258f00fff62063d68
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	THBD DPEP2 HPR AOC3 SLC27A3	2.91e-05	178	89	5	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAG DNAH10 SLC25A5 KIF12 DNAAF11	2.91e-05	178	89	5	8b7df6ab8709d9ab9dff97677cc4561aec2745bc
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAG DNAH10 SLC25A5 KIF12 DNAAF11	2.91e-05	178	89	5	b0baf5667e3301898b3e45e974b8a8530af6a338
ToppCell	droplet-Kidney-nan-3m-Hematologic-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A4 SLC25A5 NFKBID APBB1IP FGL2	3.15e-05	181	89	5	58d7e76dfaa818aeaef7f129c4472bf5b6563218
ToppCell	droplet-Kidney-nan-3m-Hematologic\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A4 SLC25A5 NFKBID APBB1IP FGL2	3.15e-05	181	89	5	5d76e99bf2b5b337041efd3cd33bebbb0637b64e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A XYLT1 FGA F5 CLDN1	3.15e-05	181	89	5	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A XYLT1 FGA F5 CLDN1	3.15e-05	181	89	5	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	droplet-Kidney-nan-3m-Hematologic-leukocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A4 SLC25A5 NFKBID APBB1IP FGL2	3.15e-05	181	89	5	970fc90e27236ee30190f1a02f418a378919c60b
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related-Microfold_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TINAG DUOX2 ALDOB SLC27A3 SOD3	3.23e-05	182	89	5	b4f347fb684f6840c166d7473f3f56389f69c14b
ToppCell	facs-Skin-Anagen-3m-Epithelial-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRYBG2 CELSR1 MOGS SMOX CLDN1	3.59e-05	186	89	5	9a7932d0a208f3997216bd21a72913cc82b59fc9
ToppCell	15-Distal-RBC\|Distal / Age, Tissue, Lineage and Cell class	RSAD2 HPR FGA ALDOB CLDN1	3.77e-05	188	89	5	c68ccb1c5c21d13ddac09b16e7d466f0530bbda5
ToppCell	15-Distal-RBC-RBC\|Distal / Age, Tissue, Lineage and Cell class	RSAD2 HPR FGA ALDOB CLDN1	3.77e-05	188	89	5	2534684e4932c1255c24a26ca2277ac7af0a118b
ToppCell	facs-Skin-nan-18m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A OLFML2B CPZ SOD3 FGL2	3.87e-05	189	89	5	29287525120be2953b76881ba3cfc4379c265e7a
ToppCell	facs-Skin-nan-18m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A OLFML2B CPZ SOD3 FGL2	3.87e-05	189	89	5	7150dad9a92a715487c2d8130fa01b752ea69663
ToppCell	facs-Skin-nan-18m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A OLFML2B CPZ SOD3 FGL2	3.87e-05	189	89	5	6e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A MASP1 KCNH2 AOC3 FGF14	3.97e-05	190	89	5	562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_monocyte_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DPEP2 F5 APBB1IP FGL2 NOD2	3.97e-05	190	89	5	b7ce76931edc6734b80ddbb2fca23b098a8c1352
ToppCell	wk_08-11-Hematologic-Myeloid-S100A12-hi_cla._mono.\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	DPEP2 HPR F5 APBB1IP FGL2	3.97e-05	190	89	5	b8c131020d20005cd9f23d26312196f62c958074
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A MASP1 KCNH2 AOC3 FGF14	3.97e-05	190	89	5	f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR83 KDM5B SLC25A5 LRP10 GOT1	3.97e-05	190	89	5	8f5e71a0861ee4e8f3ce45e8a7f18fb9d6036a3c
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TRHDE XYLT1 CPZ PZP SOD3	4.17e-05	192	89	5	ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCell	facs-Tongue-nan-3m-Epithelial-keratinocyte\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM5B THBD CRYBG2 NIPAL2 CLDN1	4.27e-05	193	89	5	33437fdb417d78463caee14a9f0e094da1733829
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-Monocytes\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DPEP2 HPR F5 APBB1IP FGL2	4.49e-05	195	89	5	6d60a364b8c5c3384a430b858435f5cc542d80e3
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_basal-Basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CELSR1 FAT2 GLB1L3 CLDN1 SOD3	4.60e-05	196	89	5	c5adab88140a465698abcbedc6505a43cae7bfd1
ToppCell	droplet-Mammary_Gland-nan-3m-Epithelial-luminal_progenitor_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PACSIN3 SMOX ALDOC CLDN1 CRY1	4.60e-05	196	89	5	22fcfb713f402ebbd43b2822f0fd919cdbfba6e4
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR1 FOXQ1 NIPAL2 FGF14 HIF3A	4.60e-05	196	89	5	dbf154b3d166ffd07be717dac8d8a3350ac63e16
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SEMA3A CELSR1 FOXQ1 ALDH18A1 CLDN1	4.71e-05	197	89	5	d6c9da7a3a6d2bcb13e2fc6605c8a59e7fb121c5
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SEMA3A CELSR1 FOXQ1 ALDH18A1 CLDN1	4.71e-05	197	89	5	80b05c8ad9c1edc5dea3236079372475431343fe
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CELSR1 FAT2 DPY19L2 GLB1L3 CLDN1	4.71e-05	197	89	5	1e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA3A DUOX1 CELSR1 FAT2 CLDN1	4.83e-05	198	89	5	19d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA3A DUOX1 CELSR1 FAT2 CLDN1	4.83e-05	198	89	5	5374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCell	Control_saline-Epithelial_airway-airway_epithelial-Airway-Club\|Control_saline / Treatment groups by lineage, cell group, cell type	CRYBG2 CELSR1 HPR ALDOB CLDN1	4.94e-05	199	89	5	5cc8b553a58669a30eb10845beb23983dcdf5a6a
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KDM5B FAT2 SLC25A5 NIPAL2 CLDN1	4.94e-05	199	89	5	ba284f984909504221900bca5ea12ada5b2ffd9f
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DUOX1 CELSR1 FAT2 HECTD1 CLDN1	5.06e-05	200	89	5	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA3A CELSR1 FAT2 GLB1L3 CLDN1	5.06e-05	200	89	5	8827653738a931e4a4545e0c7d75be12bed40740
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DUOX1 CELSR1 FAT2 HECTD1 CLDN1	5.06e-05	200	89	5	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	Biopsy_Other_PF-Epithelial-Basal\|Biopsy_Other_PF / Sample group, Lineage and Cell type	FAT2 GLB1L3 PACSIN3 CLDN1 SOD3	5.06e-05	200	89	5	7098ae4b0ea8ba607519eaed8577c577530fc2a1
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_basal-Basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FAT2 FOXQ1 GLB1L3 PACSIN3 CLDN1	5.06e-05	200	89	5	0594ca7bc313b73e1dc800cf058f8f798b0284cb
ToppCell	facs-Lung-Endomucin-24m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A4 TSPAN10 SERGEF ALDOC	1.89e-04	142	89	4	0a87c0d74e281da5dc4f59e09a5e99c62b1ea801
ToppCell	droplet-Liver-Npc-21m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIPRP1 GCDH ALDOB SOD3	2.10e-04	146	89	4	24e63124116b9a6796ae0495fc69dc6b6af28c38
ToppCell	droplet-Liver-hepatocytes-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXQ1 FGA GCDH ALDOB	2.10e-04	146	89	4	d9df42f8e44018b149a84f07c540cdba74d6374a
ToppCell	droplet-Liver-hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXQ1 FGA GCDH ALDOB	2.10e-04	146	89	4	a9fa64617c7fb7a66de77360c5642c1da91e465c
ToppCell	droplet-Liver-Npc-21m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIPRP1 GCDH ALDOB SOD3	2.10e-04	146	89	4	ae43d418492177546b7f85afffb4287d40815f88
ToppCell	droplet-Liver-hepatocytes-3m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXQ1 FGA GCDH ALDOB	2.10e-04	146	89	4	e03658ead410d003e2b18fe94da086a38560b8e7
ToppCell	droplet-Liver-hepatocytes-3m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXQ1 FGA GCDH ALDOB	2.10e-04	146	89	4	9d7122cc640500c7cd93230df06e331c31625bd5
ToppCell	PND03-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RSAD2 NFKBID APBB1IP FGL2	2.27e-04	149	89	4	2a2a5673ce4f376e7b25f2bc8127fb7e260f37af
ToppCell	PND03-Immune-Immune_Myeloid-Granulocytic-Neutrophil\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RSAD2 NFKBID APBB1IP FGL2	2.27e-04	149	89	4	c9f02ec62a658a751e591699f9395fe597e22a2e
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crhr2_Efemp1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TRHDE SEMA3A GPR83 MASP1	2.57e-04	154	89	4	a2adaa4a6cd8708cd579b8efbeb4ff2131c5482e
ToppCell	VE-Treg-naive_CD4\|VE / Condition, Cell_class and T cell subcluster	KCNH2 DPEP2 ALDOC F5	2.70e-04	156	89	4	6501baf73616e702946de9fb13d267e30a68888b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A XYLT1 OLFML2B F5	2.70e-04	156	89	4	dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A XYLT1 OLFML2B F5	2.70e-04	156	89	4	abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCell	facs-MAT-Fat-24m\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXQ1 PNLIPRP1 GKN1 ALDOB	2.70e-04	156	89	4	7433c6d4eb4d061844d8979c1e648d8ed56e1073
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CEP68 HPR CPZ PZP	2.77e-04	157	89	4	f6210be2362d833c6d869ff921188bfc85dda11d
ToppCell	facs-MAT-Fat-24m-Epithelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIPRP1 FGA GKN1 ALDOB	2.77e-04	157	89	4	30814ff90cead688ef64dac4cf4a6d63756d8944
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CEP68 HPR CPZ PZP	2.77e-04	157	89	4	43a6b423fd70479822a564ff4225a1e4951ae5ed
ToppCell	facs-MAT-Fat-24m-Epithelial\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIPRP1 FGA GKN1 ALDOB	2.77e-04	157	89	4	a47d102570e82d34ea1a8756f82636e7ab27c07f
ToppCell	facs-MAT-Fat-24m-Epithelial-epithelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIPRP1 FGA GKN1 ALDOB	2.77e-04	157	89	4	7c20f225b2db8b340f4fec050ff29e666b860f04
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MASP1 F5 CLDN1 APBB1IP	2.83e-04	158	89	4	e7db0ee4740e3c7a4d97d7cd7462e2c2ab458a4b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MASP1 F5 CLDN1 APBB1IP	2.83e-04	158	89	4	d39e020c3e77eb9d3de600a171d22f94357061d4
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-basal_intermediate_\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	DUOX1 FAT2 DUOX2 CLDN1	2.83e-04	158	89	4	98712ed7e8e65e8c5ff9318cf0e0a04e271a055d
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSAD2 APBB1IP FGL2 NOD2	2.83e-04	158	89	4	d43b335e6aa12d84a75b988fbd6127ff1f4af25c
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSAD2 APBB1IP FGL2 NOD2	2.83e-04	158	89	4	ab12b29ce51ca2fcac469cc932391217d97145f9
ToppCell	facs-Lung-EPCAM-3m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFKBID F5 FGL2 NOD2	2.97e-04	160	89	4	b73f07a0088936fbc3656a05710a67f38b4ae551
ToppCell	390C-Epithelial_cells-Epithelial-H_(AT1)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	FAT2 FOXQ1 GLB1L3 CLDN1	2.97e-04	160	89	4	18ae6822915d16699beb9047baeef9b006901a35
ToppCell	390C-Epithelial_cells-Epithelial-H_(AT1)\|390C / Donor, Lineage, Cell class and subclass (all cells)	FAT2 FOXQ1 GLB1L3 CLDN1	2.97e-04	160	89	4	830f17bad94de05612fe6d53d39e42a4b3f3e2f3
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFKBID F5 FGL2 NOD2	2.97e-04	160	89	4	b88876a58fea2066468e74dcc439c8561130a910
ToppCell	PND07-Endothelial-Endothelial_lymphatic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CELSR1 DUOX2 ALDOB FGL2	3.04e-04	161	89	4	133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CELSR1 DUOX2 ALDOB FGL2	3.04e-04	161	89	4	9466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CELSR1 DUOX2 ALDOB FGL2	3.04e-04	161	89	4	cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCell	facs-SCAT-Fat-24m\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIPRP1 FGA GKN1 ALDOB	3.12e-04	162	89	4	b824f30c723c9c7d8e8c8a8dc3f88d4eed29dd67
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CELSR1 DUOX2 ALDOB FGL2	3.12e-04	162	89	4	96c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Igfbp4-Inhibitory_Neuron.Gad1Gad2.Igfbp4.Adora1_(Striatum,_interneuron)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	DUOX1 SMIM9 PRDM12	3.13e-04	66	89	3	d6b202d9f5bebaac23b34b689ad306549dec0593
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Igfbp4-Inhibitory_Neuron.Gad1Gad2.Igfbp4.Adora1_(Striatum,_interneuron)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	DUOX1 SMIM9 PRDM12	3.13e-04	66	89	3	4a714cf035b22da103054098f85f9170c56e9e83
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	GPR83 DUOX1 PRDM12	3.13e-04	66	89	3	88afd3ab91774ce01ff4277395b7b59dbb23200a
ToppCell	facs-SCAT-Fat-24m-Epithelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIPRP1 FGA GKN1 ALDOB	3.19e-04	163	89	4	9fd2e495efb6c447cdc52efdb3b695cb2fa8b914
ToppCell	facs-SCAT-Fat-24m-Epithelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIPRP1 FGA GKN1 ALDOB	3.19e-04	163	89	4	ade2f59bca0ab0c4856202f980464f3287bddd24
ToppCell	facs-SCAT-Fat-24m-Epithelial-epithelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIPRP1 FGA GKN1 ALDOB	3.19e-04	163	89	4	aaf5d96bab1957c7bde84c741c7f2fb86ef41e8b
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	RSAD2 DSCR9 HIF3A FGL2	3.26e-04	164	89	4	362c16ed7fb37bf16601fd5e059d3f3e2ed692b4
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZRSR2P1 RSAD2 F5 NOD2	3.26e-04	164	89	4	f9a2cc12179d5621c9174ec01d7418a71edd28d1
ToppCell	facs-Lung-3m-Hematologic-myeloid-neutrophil-neutrophil\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NFKBID F5 FGL2 NOD2	3.42e-04	166	89	4	3195035445d35d820f5e00dd03b029730478b024
ToppCell	facs-Kidney-nan-24m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIPRP1 PZP ALDOB SOD3	3.42e-04	166	89	4	fe87b444fc0ef6fc20c646c9d2c3c8ce916a70c0
ToppCell	facs-Lung-3m-Hematologic-myeloid-neutrophil\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NFKBID F5 FGL2 NOD2	3.42e-04	166	89	4	6b6ecd70264b6bfbd8a3a378c965702829e2ecf1
ToppCell	droplet-Spleen-nan-21m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFML2B F5 CLDN1 DGAT1	3.50e-04	167	89	4	cfcd72292c733cdb18c92fdb61b68f6806d22c8c
ToppCell	facs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A42 RSAD2 NOX1 SMOX	3.58e-04	168	89	4	17fb9426eeea407b26fb895b8397faca95b7552d
Drug	MnTM-2-PyP5+	DUOX1 NOX1 BAX DUOX2 SOD3	1.43e-07	32	88	5	CID000153503
Drug	probucol	DUOX1 NOX1 LRP10 FGA DUOX2 F5 SOD3 FGL2	2.19e-07	162	88	8	CID000004912
Drug	dihydroethidium	DUOX1 NOX1 BAX DUOX2 CLDN1 SOD3	1.85e-06	95	88	6	CID000128682
Drug	coelenterazine	DUOX1 NOX1 DUOX2 SOD3	3.42e-06	27	88	4	CID000002830
Drug	3,4,5,3',4'-pentachlorobiphenyl	FOXO3 THBD MASP1 RSAD2 FOXQ1 GLB1L3 KCNH2 DPEP2 CYP11A1 FGA BAX NIPAL2 CPZ NR3C1 ALDOB ALDOC SLC27A3	3.62e-06	1219	88	17	ctd:C023035
Drug	L 012	DUOX1 NOX1 DUOX2 SOD3	4.60e-06	29	88	4	CID000126741
Drug	oxypurinol	DUOX1 NOX1 DUOX2 GOT1 SOD3	8.77e-06	72	88	5	CID000004644
Drug	LMWH	SEMA3A XYLT1 THBD MASP1 PNLIPRP1 FGA KCNQ2 FGF14 NR3C1 F5 SOD3 FGL2	9.16e-06	663	88	12	CID000000772
Drug	CAS 76095-16-4	DUOX1 NOX1 FGA DUOX2 F5 FGL2	9.53e-06	126	88	6	CID000003222
Drug	S-2238	THBD FGA F5 FGL2	1.12e-05	36	88	4	CID000123853
Drug	Ketoprofen [22071-15-4]; Up 200; 15.8uM; MCF7; HT_HG-U133A	MASP1 FAT2 NOX1 KCNH2 FGA NR3C1 ALDOB	1.22e-05	199	88	7	3626_UP
Drug	Tracazolate hydrochloride [41094-88-6]; Up 200; 11.8uM; HL60; HT_HG-U133A	SEMA3A CRYBG2 PRDM12 GCDH GKN1 F5 NOD2	1.26e-05	200	88	7	2919_UP
Drug	D-Phe-Pro-Arg-CMK	THBD FGA F5 FGL2	1.39e-05	38	88	4	CID000439822
Drug	NSC233046	PNLIPRP1 FGA FGF14 F5 FGL2	1.87e-05	84	88	5	CID000005277
Drug	2-keto-4-hydroxyglutarate	ALDOB ALDOC GOT1	1.97e-05	14	88	3	CID000000599
Drug	DCFH-DA	DUOX1 NOX1 BAX DUOX2 SOD3	2.09e-05	86	88	5	CID000104913
Drug	quinaprilat	DUOX1 NOX1 BAX DUOX2	2.29e-05	43	88	4	CID000107994
Drug	hydroethidine	DUOX1 NOX1 DUOX2 SOD3	2.51e-05	44	88	4	CID000065410
Drug	1dwc	THBD FGA F5 FGL2	2.75e-05	45	88	4	CID000002232
Drug	AC1L1HMM	DUOX1 RSAD2 NOX1 CYP11A1 HPR BAX DUOX2 NR3C1 GKN1 ALDOC	3.04e-05	516	88	10	CID000004196
Drug	AC1L1GI5	GPR83 DUOX1 NOX1 DUOX2	3.27e-05	47	88	4	CID000003693
Drug	diisopropylfluorophosphate	TRHDE THBD MASP1 DPEP2 FGA CPZ F5 FGL2	3.46e-05	321	88	8	CID000005936
Drug	tolcapone	MASP1 SLC25A5 KCNH2 FGA ALDH18A1 GCDH NR3C1 F5	4.03e-05	328	88	8	ctd:C066340
Drug	Zithromac	FGA NR3C1 SMOX CLDN1 FGL2	4.13e-05	99	88	5	CID000002269
Drug	NSC236997	FOXO3 GPR83 DUOX1 NOX1 AOC3 BAX DUOX2 NR3C1 GOT1 SOD3	4.39e-05	539	88	10	CID000005300
Drug	acetol phosphate	ALDOB ALDOC	4.42e-05	3	88	2	CID000150865
Drug	4-hydroxy-9-fluorenone	ALDOB ALDOC	4.42e-05	3	88	2	CID000016139
Drug	Htfp	ALDOB ALDOC	4.42e-05	3	88	2	CID000125055
Drug	DIDIT	ALDOB ALDOC	4.42e-05	3	88	2	CID000196082
Drug	2-keto-3-deoxy- l-lyxonate	ALDOB ALDOC	4.42e-05	3	88	2	CID000192781
Drug	androisoxazole	ALDOB ALDOC	4.42e-05	3	88	2	CID000009676
Drug	2-keto-3-bromobutyrate	ALDOB ALDOC	4.42e-05	3	88	2	CID000191968
Drug	3-isochromanone	ALDOB ALDOC	4.42e-05	3	88	2	CID000078092
Drug	5-deoxy-5-fluoro-L-sorbose	ALDOB ALDOC	4.42e-05	3	88	2	CID000191809
Drug	D-ribulose-1-p	ALDOB ALDOC	4.42e-05	3	88	2	CID000000615
Drug	4-hydroxy-2-ketopimelate	ALDOB ALDOC	4.42e-05	3	88	2	CID000000553
Drug	AC1L19F1	ALDOB ALDOC	4.42e-05	3	88	2	CID000000519
Drug	N-acetylcysteine	FOXO3 DUOX1 NOX1 HPR PACSIN3 BAX DUOX2 NR3C1 GOT1 SOD3	4.89e-05	546	88	10	CID000000581
Drug	AC1L2YVP	HPR ALDOB ALDOC	5.17e-05	19	88	3	CID000080135
Drug	vitamin E	THBD PNLIPRP1 LRP10 HPR BAX NR3C1 GOT1 SOD3 NOD2	5.23e-05	441	88	9	CID000002116
Drug	Mifepristone	FOXO3 SLC7A4 FOXQ1 AOC3 BAX CPZ NR3C1 ALDOC CLDN1 SOD3	5.44e-05	553	88	10	ctd:D015735
Drug	S 2160	FGA F5 FGL2	6.06e-05	20	88	3	CID000189147
Drug	tetrahydrobiopterin	DUOX1 NOX1 BAX DUOX2 SOD3 NOD2	6.48e-05	177	88	6	CID000001125
Drug	carnitine	SLC25A5 FGA COX10 GCDH DGAT1 SOD3 FGL2	7.60e-05	265	88	7	CID000000085
Drug	NSC115907	DUOX1 NOX1 SLC25A5 PACSIN3 BAX DUOX2 SOD3	7.78e-05	266	88	7	CID000005102
Drug	homocysteine	THBD LMBR1L FGA BAX F5 SOD3 FGL2	7.78e-05	266	88	7	CID000000778
Drug	AC-474	AOC3 FGA F5 FGL2	8.06e-05	59	88	4	CID000002999
Drug	AC1NAE4O	DUOX1 NOX1 FGA DUOX2 FGL2	8.45e-05	115	88	5	CID004475485
Drug	AC1L1J6W	SEMA3A MASP1 DPEP2 FGA NR3C1 FGL2	8.53e-05	186	88	6	CID000004894
Drug	formylacetate	ALDOB ALDOC	8.82e-05	4	88	2	CID000075269
Drug	dihydroxyacetone sulfate	ALDOB ALDOC	8.82e-05	4	88	2	CID000439751
Drug	SC-47643	FGA FGL2	8.82e-05	4	88	2	CID000124392
Drug	C06441	ALDOB ALDOC	8.82e-05	4	88	2	CID000441020
Drug	TA-993	FGA FGL2	8.82e-05	4	88	2	CID000129579
Drug	3-hydroxy-1-indanone	ALDOB ALDOC	8.82e-05	4	88	2	CID000176448
Drug	l-123	ALDOB ALDOC	8.82e-05	4	88	2	CID000093552
Drug	AC1Q3E6A	AOC3 NR3C1	8.82e-05	4	88	2	CID000068318
Drug	spermic acid	AOC3 SMOX	8.82e-05	4	88	2	CID000167029
Drug	carbendazim	BAX DNAAF11 DGAT1 SOD3	9.19e-05	61	88	4	ctd:C006698
Drug	2-carboxybenzaldehyde	KCNH2 ALDOB ALDOC	9.34e-05	23	88	3	CID000008406
Drug	Chlorpheniramine maleate [113-92-8]; Up 200; 10.2uM; PC3; HT_HG-U133A	CRYBG2 SLC22A13 BAX PRDM12 F5 DOP1A	1.04e-04	193	88	6	2055_UP
Drug	AC1L1EW8	GPR83 FGA FGL2	1.06e-04	24	88	3	CID000002976
Drug	Omeprazole [73590-58-6]; Up 200; 11.6uM; MCF7; HT_HG-U133A	THBD KCNH2 SERGEF DNAAF11 HIF3A DOP1A	1.07e-04	194	88	6	4951_UP
Drug	losartan	GPR83 DUOX1 FAT2 NOX1 KCNH2 BAX DUOX2 SOD3	1.08e-04	378	88	8	CID000003961
Drug	Berberine chloride [633-65-8]; Down 200; 10.8uM; PC3; HT_HG-U133A	CEP68 TRAPPC11 LZTR1 MOGS PACSIN3 GCDH	1.14e-04	196	88	6	7143_DN
Drug	Rapamycin; Up 200; 0.1uM; HL60; HT_HG-U133A	CELSR1 NOX1 OLFML2B BAX PRDM12 NOD2	1.17e-04	197	88	6	6180_UP
Drug	niacin	SLC22A13 HPR FGA GOT1 DGAT1 FGL2	1.20e-04	198	88	6	CID000000937
Drug	Trolox [53188-07-1]; Up 200; 16uM; MCF7; HT_HG-U133A	THBD CRYBG2 LMBR1L OLFML2B CLDN1 DOP1A	1.24e-04	199	88	6	6007_UP
Drug	Clotrimazole	KCNH2 NR3C1 ALDOB GOT1	1.25e-04	66	88	4	ctd:D003022
Drug	oxygen	DUOX1 NOX1 CYP11A1 AOC3 BAX COX10 DUOX2 DNAAF11 SOD3	1.34e-04	499	88	9	CID000000977
Drug	1,3-dioxan-5-one	ALDOB ALDOC	1.47e-04	5	88	2	CID009793707
Drug	AC1L4F2K	ALDOB ALDOC	1.47e-04	5	88	2	CID000184526
Drug	gamma-oxalocitramalate	ALDOB ALDOC	1.47e-04	5	88	2	CID000000130
Drug	2,3-dihydroxy-p-cumate	ALDOB ALDOC	1.47e-04	5	88	2	CID000029587
Drug	AC1NX490	ALDOB ALDOC	1.47e-04	5	88	2	CID005743230
Drug	phosphoglycollamide	ALDOB ALDOC	1.47e-04	5	88	2	CID000191768
Drug	D-erythrulose 1-phosphate	ALDOB ALDOC	1.47e-04	5	88	2	CID000152153
Drug	hydroxypyruvaldehyde phosphate	ALDOB ALDOC	1.47e-04	5	88	2	CID000193787
Drug	dihydroquinoline	HPR NR3C1	1.47e-04	5	88	2	CID005231402
Drug	NSC4322	THBD FGA F5 FGL2	1.49e-04	69	88	4	CID000220862
Drug	pyridoxal 5'-phosphate	AOC3 FGA NR3C1 ALDOB ALDOC GOT1 FGL2	1.67e-04	301	88	7	CID000001051
Drug	epicholesterol	GPR83 PNLIPRP1 LRP10 CYP11A1 FGA NR3C1 HECTD1 GOT1 DGAT1 FGL2	1.72e-04	636	88	10	CID000000304
Drug	NOC-18	CYP11A1 BAX CLDN1 SOD3	1.85e-04	73	88	4	CID000001606
Drug	DNPH	MASP1 AOC3 SOD3	1.90e-04	29	88	3	CID003772977
Drug	1-o-phosphonohex-2-ulose	HPR ALDOB ALDOC	1.90e-04	29	88	3	CID000000481
Drug	coumarin	TRHDE THBD BAX F5 GOT1	2.06e-04	139	88	5	CID000000323
Drug	inogatran	THBD FGA FGL2	2.10e-04	30	88	3	CID000066005
Drug	tempol	DUOX1 NOX1 BAX DUOX2 GCDH SOD3	2.18e-04	221	88	6	CID000137994
Drug	mycestericin D	ALDOB ALDOC	2.19e-04	6	88	2	CID006439504
Drug	lefradafiban	FGA FGL2	2.19e-04	6	88	2	CID009576916
Drug	RU-43044	HPR NR3C1	2.19e-04	6	88	2	CID000188913
Drug	C02783	ALDOB ALDOC	2.19e-04	6	88	2	CID000439805
Drug	2,2-dimethyl-1,3-dioxan-5-one	ALDOB ALDOC	2.19e-04	6	88	2	CID002733141
Drug	2-(N-decyl)aminonaphthalene-6-sulfonic acid	ALDOB ALDOC	2.19e-04	6	88	2	CID000189836
Drug	Rgdy	FGA FGL2	2.19e-04	6	88	2	CID000129979
Drug	parapyruvate	ALDOB ALDOC	2.19e-04	6	88	2	CID000440249
Drug	acetyldithio-CoA	ALDOB ALDOC	2.19e-04	6	88	2	CID003082679
Drug	0 Gz	ALDOB ALDOC	2.19e-04	6	88	2	CID000000372
Drug	elarofiban	FGA FGL2	2.19e-04	6	88	2	CID000216230
Drug	chloroacetol phosphate	ALDOB ALDOC	2.19e-04	6	88	2	CID000168137
Disease	dermoid cyst of ovary (implicated_via_orthology)	FOXO3 FOXO3B	8.20e-06	2	85	2	DOID:5117 (implicated_via_orthology)
Disease	phenylketonuria (implicated_via_orthology)	DUOX1 DUOX2	4.90e-05	4	85	2	DOID:9281 (implicated_via_orthology)
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	THBD CYP11A1 HPR BAX ALDOB	6.82e-05	147	85	5	DOID:9352 (biomarker_via_orthology)
Disease	Crohn's disease (is_marker_for)	THBD FGA DUOX2	7.99e-05	29	85	3	DOID:8778 (is_marker_for)
Disease	Colonic Neoplasms	KDM5B NOX1 KCNH2 BAX F5	7.99e-05	152	85	5	C0009375
Disease	Malignant tumor of colon	KDM5B NOX1 KCNH2 BAX F5	9.88e-05	159	85	5	C0007102
Disease	Iron deficiency anemia	DUOX2 F5	1.22e-04	6	85	2	HP_0001891
Disease	middle cerebral artery infarction (biomarker_via_orthology)	NOX1 HPR BAX NOD2	1.54e-04	93	85	4	DOID:3525 (biomarker_via_orthology)
Disease	Venous Thromboembolism	FGA F5	2.27e-04	8	85	2	C1861172
Disease	primary bacterial infectious disease (implicated_via_orthology)	DUOX1 DUOX2	2.91e-04	9	85	2	DOID:0050338 (implicated_via_orthology)
Disease	Thrombophilia	THBD FGA	2.91e-04	9	85	2	C0398623
Disease	post-traumatic stress disorder (biomarker_via_orthology)	BAX NR3C1	2.91e-04	9	85	2	DOID:2055 (biomarker_via_orthology)
Disease	Thrombus	THBD FGA F5	3.20e-04	46	85	3	C0087086
Disease	long QT syndrome (implicated_via_orthology)	KCNH2 KCNQ2	3.64e-04	10	85	2	DOID:2843 (implicated_via_orthology)
Disease	venous thromboembolism	THBD RSAD2 FGA PACSIN3 CATSPERB FGF14 F5	3.71e-04	460	85	7	EFO_0004286
Disease	Thrombosis	THBD FGA F5	3.86e-04	49	85	3	C0040053
Disease	liver benign neoplasm (biomarker_via_orthology)	KMT5C ALDOB	4.44e-04	11	85	2	DOID:916 (biomarker_via_orthology)
Disease	Acute Cerebrovascular Accidents	FGA SMOX F5	5.15e-04	54	85	3	C0751956
Disease	Pulmonary Thromboembolisms	THBD FGA	5.31e-04	12	85	2	C0524702
Disease	Pulmonary Embolism	THBD FGA	5.31e-04	12	85	2	C0034065
Disease	pulmonary embolism (biomarker_via_orthology)	HPR FGA	5.31e-04	12	85	2	DOID:9477 (biomarker_via_orthology)
Disease	hypothyroidism (implicated_via_orthology)	DUOX1 DUOX2	6.27e-04	13	85	2	DOID:1459 (implicated_via_orthology)
Disease	congenital hypothyroidism (implicated_via_orthology)	DUOX1 DUOX2	7.30e-04	14	85	2	DOID:0050328 (implicated_via_orthology)
Disease	T wave morphology measurement	KCNH2 OLFML2B	7.30e-04	14	85	2	EFO_0008398
Disease	acute kidney failure (biomarker_via_orthology)	HPR FGA BAX	7.36e-04	61	85	3	DOID:3021 (biomarker_via_orthology)
Disease	Cerebrovascular accident	FGA SMOX F5	7.72e-04	62	85	3	C0038454
Disease	chronic obstructive pulmonary disease (is_implicated_in)	NR3C1 SOD3 NOD2	8.09e-04	63	85	3	DOID:3083 (is_implicated_in)
Disease	mannan-binding lectin serine protease 1 measurement	MASP1 NXPE1	8.40e-04	15	85	2	EFO_0008223
Disease	Paroxysmal atrial fibrillation	CEP68 DNAH10 KCNH2 NR3C1	1.09e-03	156	85	4	C0235480
Disease	prostate cancer (is_marker_for)	FOXO3 KDM5B PNLIPRP1 BAX	1.09e-03	156	85	4	DOID:10283 (is_marker_for)
Disease	familial atrial fibrillation	CEP68 DNAH10 KCNH2 NR3C1	1.09e-03	156	85	4	C3468561
Disease	Persistent atrial fibrillation	CEP68 DNAH10 KCNH2 NR3C1	1.09e-03	156	85	4	C2585653
Disease	Drug-Induced Liver Disease	FGA BAX PZP ALDOB GOT1 SOD3	1.12e-03	404	85	6	C0860207
Disease	Drug-Induced Acute Liver Injury	FGA BAX PZP ALDOB GOT1 SOD3	1.12e-03	404	85	6	C3658290
Disease	Hepatitis, Toxic	FGA BAX PZP ALDOB GOT1 SOD3	1.12e-03	404	85	6	C0019193
Disease	Chemically-Induced Liver Toxicity	FGA BAX PZP ALDOB GOT1 SOD3	1.12e-03	404	85	6	C4279912
Disease	Chemical and Drug Induced Liver Injury	FGA BAX PZP ALDOB GOT1 SOD3	1.12e-03	404	85	6	C4277682
Disease	Hepatitis, Drug-Induced	FGA BAX PZP ALDOB GOT1 SOD3	1.12e-03	404	85	6	C1262760
Disease	Atrial Fibrillation	CEP68 DNAH10 KCNH2 NR3C1	1.20e-03	160	85	4	C0004238
Disease	cardiomyopathy (is_implicated_in)	POMT1 DGAT1	1.36e-03	19	85	2	DOID:0050700 (is_implicated_in)
Disease	Drug toxicity	THBD FGA NR3C1	1.86e-03	84	85	3	C0013221
Disease	Adverse reaction to drug	THBD FGA NR3C1	1.86e-03	84	85	3	C0041755
Disease	arginine measurement	FOXQ1 GCDH	1.99e-03	23	85	2	EFO_0020990
Disease	Myocardial Infarction	THBD BAX F5	2.64e-03	95	85	3	C0027051

Protein segments in the cluster

Peptide	Gene	Start	Entry
GSWLLGNINQTGYFR	TRHDE	676	Q9UKU6
AYNLNRAFTWLGGSG	ARSH	76	Q5FYA8
STWFLYNFGQRNGRT	CATSPERB	696	Q9H7T0
GLGRRRLSFQAEYWA	CEP68	261	Q76N32
SYGRALQASALNAWR	ALDOC	301	P09972
SYGRALQASALAAWG	ALDOB	301	P05062
NYQRAVAKAGLASRW	APBB1IP	426	Q7Z5R6
RTQFWLYFAGNLASG	SLC25A5	106	P05141
FNALSWGLREDYSRG	COX10	326	Q12887
RRLYAWLLGFDNNGA	DOP1A	286	Q5JWR5
ANLRYRVLGGAWDVF	CELSR1	386	Q9NYQ6
QRGYRWAGFIVAAGS	SLC7A4	311	O43246
RFFQGNYGNAAVWLS	DGAT1	446	O75907
RGLQSGDRATWFGLY	AOC3	216	Q16853
ERYGRNQGNTWLTAF	PZP	1036	P20742
GDRYWFENTRNGLFS	DUOX1	511	Q9NRD9
GFLNYRLFLTGWDSN	NOX1	466	Q9Y5S8
AWSNGRGFNATYHVR	LRP10	291	Q7Z4F1
KLWIFAGYDGNARLN	LZTR1	186	Q8N653
RALTLGGWTARYFQS	KMT5C	66	Q86Y97
FAARGLRWAAYAAAE	NFKBID	56	Q8NI38
SLLNWNYGFVFINGR	GLB1L3	591	Q8NCI6
LLWGRQLFALYSGND	HPR	11	P00739
LSGARVAWAQRNLYG	KIF12	406	Q96FN5
LGDFGRFNWLGNFYI	LMBR1	416	Q8WVP7
NIFSFWGDSRGRQYQ	KCNH2	996	Q12809
LRDGDRYWFENTRNG	DUOX2	511	Q9NRD8
RRAGYNLSLWASDGG	FAT2	991	Q9NYQ8
AAGLIQSAWRFYATN	KCNQ2	336	O43526
NTGEASNFARWRYGV	PNLIPRP1	346	P54315
LYRQQESGRAWFLGL	FGF14	161	Q92915
WASNSNYALIGALRA	MT-ND1	121	P03886
FALGWRSYRQSSANL	NR3C1	606	P04150
RVGSGLLYSRWQASA	KDM5B	1281	Q9UGL1
FLYGRWRNVLGEQLF	PRDM12	36	Q9H4Q4
GYANLRNQWSIIGEF	DPY19L2	601	Q6NUT2
DWQNFVGRRRYGAES	GPR83	51	Q9NYM4
NRGFSGYNTRWAKII	IAH1	51	Q2TAA2
WNASTRFSDGYRFGL	ALDH18A1	721	P54886
RGAVWLNVNYLALGA	MOGS	751	Q13724
GFDGNFLWNRIGAEY	POMT1	81	Q9Y6A1
SSRRNAWGNLSYADL	FOXO3B	236	A0A2Z4LIS9
RGYGRSALRNWVFQV	HECTD1	1156	Q9ULT8
NSIWDYGNGFAATRL	GKN1	61	Q9NS71
NFLKRGSIINGADWY	CPZ	436	Q66K79
NARYEFGQALFTGWA	CLDN1	156	O95832
AYSRRGWENAALFLN	DSCR9	91	P59020
NNARYGIAWGVLGAS	GCDH	291	Q92947
SDGNFNWGRVVALFY	BAX	101	Q07812
QRRVYFRLWNAALGG	CRYBG2	1526	Q8N1P7
FAGSSNVGINRWRFL	CRY1	41	Q16526
GALRIGADFLARWYN	GOT1	111	P17174
NITYFRNLGFGWGVR	CYP11A1	446	P05108
RSNAGFDGRWYTDIN	DNAAF11	201	Q86X45
GSLNFNRTWQDYKRG	FGA	681	P02671
NRTWQDYKRGFGSLN	FGA	686	P02671
ENRGWRLSYRAAGNE	MASP1	286	P48740
RTWQDYKAGFGNLRR	FGL2	266	Q14314
RLRDGLVGAQFWSAY	DPEP2	121	Q9H4A9
FRSGYKRLNWNSLGI	DNAH10	741	Q8IVF4
AGLAYGFRNWRLLQI	SLC22A13	241	Q9Y226
WGDGIRGLSLNAARY	SLC12A7	661	Q9Y666
FRGSYTGWRNSVRHN	FOXQ1	156	Q9C009
SEGASALWRARNQGY	NXPE1	186	Q8N323
ALGGSFWEAGNYRRT	PACSIN3	11	Q9UKS6
SSRRNAWGNLSYADL	FOXO3	151	O43524
ALFAWGANSYGQLGL	SERGEF	16	Q9UGK8
NTSYSRWARLDLNGA	THBD	116	P07204
SNGSLIRERWFQNYG	RSAD2	156	Q8WXG1
LARLNNGGSYNAWSV	F5	1936	P12259
LGDFGRFNWLGNFYI	LMBR1L	421	Q6UX01
AGNGSLSGDWYRRNQ	NIPAL2	31	Q9H841
FLARSGGYLWTQTQA	HIF3A	306	Q9Y2N7
GGYWAGLTEANRLQR	SPPL2C	201	Q8IUH8
YLNEGFLSLWRGNSA	SLC25A42	81	Q86VD7
FWGVLLTARANYQNG	SEMA3A	11	Q14563
ETTWRTGLRRNFYGN	OLFML2B	661	Q68BL8
GGSDWFLLNRRFVEY	XYLT1	491	Q86Y38
TGVLDFYGQRSWRQG	TRAPPC11	386	Q7Z392
FYGQRSWRQGILSFD	TRAPPC11	391	Q7Z392
RGNTSLQFLGFWGNR	NOD2	896	Q9HC29
SGGNHRSWLNNFRDY	SMIM9	46	A6NGZ8
NYTGQRGAVGRASWL	SLC27A3	436	Q5K4L6
FGNFAVRDGSLWRYR	SOD3	146	P08294
NYLSRVKNAWGGDFL	SPDYC	251	Q5MJ68
RILRSAWGSNPYFRG	SMOX	466	Q9NWM0
GVAWLLQNRGREAYF	TTC23L	171	Q6PF05
WLRANLAASGGYAIA	TSPAN10	286	Q9H1Z9
QAALSLFNGRWYAGR	ZRSR2P1	286	Q15695
NDAGVALWRAFNYIA	UGGT2	531	Q9NYU1
SWGENGYFRILRGVN	TINAG	441	Q9UJW2
QAALSLFNGRWYAGR	ZRSR2	281	Q15696