Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coactivator binding

TRERF1 ATF7

1.32e-0354202GO:0001223
GeneOntologyMolecularFunctiontranscription coregulator binding

TRERF1 ATF7

8.54e-03140202GO:0001221
DomainSANT_dom

TRERF1 NCOR2

3.14e-0426192IPR017884
DomainSANT

TRERF1 NCOR2

3.65e-0428192PS51293
DomainMyb_DNA-binding

TRERF1 NCOR2

5.72e-0435192PF00249
DomainMYB_LIKE

TRERF1 NCOR2

6.74e-0438192PS50090
DomainTF_fork_head_CS_2

FOXD4 FOXD4L1

9.88e-0446192IPR030456
DomainTF_fork_head_CS_1

FOXD4 FOXD4L1

1.03e-0347192IPR018122
DomainFORK_HEAD_3

FOXD4 FOXD4L1

1.12e-0349192PS50039
DomainFH

FOXD4 FOXD4L1

1.12e-0349192SM00339
DomainFORK_HEAD_1

FOXD4 FOXD4L1

1.12e-0349192PS00657
DomainFORK_HEAD_2

FOXD4 FOXD4L1

1.12e-0349192PS00658
DomainForkhead

FOXD4 FOXD4L1

1.12e-0349192PF00250
DomainFork_head_dom

FOXD4 FOXD4L1

1.12e-0349192IPR001766
DomainSANT

TRERF1 NCOR2

1.17e-0350192SM00717
DomainSANT/Myb

TRERF1 NCOR2

1.26e-0352192IPR001005
Domain-

FOXD4 FOXD4L1

2.04e-022181921.10.10.10
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TRERF1 NCOR2 FASN MSTO1 FAM193A

3.27e-0641820534709266
Pubmed

Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.

FOXD4 FOXD4L1

4.71e-06620227092474
Pubmed

HDAC3 Is a Master Regulator of mTEC Development.

NCOR2 MAP3K14

8.78e-06820227068467
Pubmed

The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.

FOXD4 FOXD4L1

8.78e-0682028530406
Pubmed

An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.

FOXD4 FOXD4L1

1.13e-05920212412011
Pubmed

Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.

FOXD4 FOXD4L1

1.72e-051120212421752
Pubmed

Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

FOXD4 FOXD4L1

2.44e-05132027957066
Pubmed

A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.

FOXD4 FOXD4L1

2.44e-051320216884697
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

TRERF1 POM121C NCOR2 FASN FAM193A

2.86e-0565520535819319
Pubmed

Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.

FOXD4 FOXD4L1

3.28e-051520222045912
Pubmed

Six members of the mouse forkhead gene family are developmentally regulated.

FOXD4 FOXD4L1

3.28e-05152027689224
Pubmed

Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.

FOXD4 FOXD4L1

3.75e-05162028861101
Pubmed

Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.

FOXD4 FOXD4L1

3.75e-051620210208738
Pubmed

Functional equivalency between Otx2 and Otx1 in development of the rostral head.

FOXD4 FOXD4L1

5.34e-05192029895322
Pubmed

Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.

FOXD4 FOXD4L1

5.93e-052020212812790
Pubmed

Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.

FOXD4 FOXD4L1

6.55e-05212029449667
Pubmed

Diverse fates of paralogs following segmental duplication of telomeric genes.

FOXD4 FOXD4L1

7.21e-052220215233989
Pubmed

Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.

FOXD4 FOXD4L1

7.21e-052220217389379
Pubmed

Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.

FOXD4 FOXD4L1

8.61e-052420211820816
Pubmed

A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.

FOXD4 FOXD4L1

8.61e-052420229992973
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

TRERF1 POM121C NCOR2 FAM193A

9.54e-0543020435044719
Pubmed

Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.

FOXD4 FOXD4L1

1.01e-042620215857913
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

ATF7 NCOR2 FASN FOXD4 FOXD4L1

1.02e-0485720525609649
Pubmed

Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.

FOXD4 FOXD4L1

1.26e-042920222972626
Pubmed

Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.

MPDZ FASN

2.42e-044020230865227
Pubmed

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.

TRERF1 NCOR2

3.06e-044520221258344
Pubmed

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.

MPDZ FAM234B FASN

4.78e-0427020324366813
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

TRERF1 NCOR2

5.46e-0453122532
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRERF1 FAM234B MAP3K14

5.56e-051682034c402a1613fcf0a6e4d9b9d5551812940e91ff32
ToppCell(7)_MNP-(7)_DC_activated|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)

FOXD4 MAP3K14 FOXD4L1

5.76e-051702034ab495b38a071fa8207331df2ce0d78a2dcd034e
ToppCellwk_15-18-Hematologic-Myeloid-aDC_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FOXD4 MAP3K14 FOXD4L1

6.50e-05177203ccf5dc54780d6039a4d062dee88440c011ddc0a3
ToppCellwk_20-22-Hematologic-Myeloid-aDC_1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

FOXD4 MAP3K14 FOXD4L1

6.61e-05178203fd2bdb4796e86c8cff2d25f0c730ffea21db8787
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FOXD4 MAP3K14 FOXD4L1

6.83e-05180203067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FOXD4 MAP3K14 FOXD4L1

6.83e-0518020332d871738a24071b70084a7e80148a516110c78b
ToppCellAdult|World / Lineage, Cell type, age group and donor

FAM83E NCOR2 FASN

7.89e-051892035cd285bfad973125d46d704fec18b21266a63379
Diseaseergothioneine measurement

MPDZ CYP21A2

1.26e-0426192EFO_0021163
Diseaseserum urea measurement

MSTO1 CYP21A2 FANCA

2.55e-04195193EFO_0009795
Diseasehomocysteine measurement

CYP21A2 FANCA

4.00e-0446192EFO_0004578
Diseasemonocyte percentage of leukocytes

TRERF1 ATF7 MAP3K14 FANCA

1.08e-03731194EFO_0007989
Diseaseplatelet component distribution width

SIRPD NCOR2 CYP21A2 GP1BA

1.21e-03755194EFO_0007984
Diseasesystemic lupus erythematosus

POM121C SIRPD CYP21A2 FAM193A

1.49e-03799194MONDO_0007915
Diseaseneutrophil count

TRERF1 ATF7 MSTO1 CYP21A2 FANCA

1.50e-031382195EFO_0004833
Diseaseeosinophil count

TRERF1 NCOR2 CYP21A2 FAM193A MAP3K14

2.08e-031488195EFO_0004842
Diseasemyeloid white cell count

FAM83E ATF7 CYP21A2 MAP3K14

2.67e-03937194EFO_0007988
Diseaseplatelet crit

SIRPD CYP21A2 GP1BA MAP3K14

2.83e-03952194EFO_0007985
Diseasemean platelet volume

SIRPD CYP21A2 GP1BA FANCA

3.63e-031020194EFO_0004584

Protein segments in the cluster

PeptideGeneStartEntry
RHLPYISLHPWLPSP

nan

231

Q9N2J8
LPLHLGYDPLHPTLP

ATF7

156

P17544
HLPRPLIHPTLYATP

FAM193A

466

P78312
LPRHLAPNPTYPHLY

NCOR2

1651

Q9Y618
YLPPPLLRHRLKTHT

LETMD1

266

Q6P1Q0
LLLPSRPAPPRHAPY

CDH24

576

Q86UP0
SLHLPPLAPGFLHLL

CYP21A2

26

P08686
HLLLTPCRVAPPYPH

MSTO1

466

Q9BUK6
PPSLHHLYLLHPAFP

FAM234B

516

A2RU67
YALLHPHPPRYLLLS

FOXD4

256

Q12950
VHHFYPSLPTPLLRP

POM121C

171

A8CG34
PRYLQVHILHPPLVP

FANCA

486

O15360
LLLLLPSPLHPHPIC

GP1BA

6

P07359
RRPYALLHPHPPRYL

FOXD4L1

256

Q9NU39
LLHPHPPRYLLLSAP

FOXD4L1

261

Q9NU39
HLYSRIPGLLSPHPL

FASN

1251

P49327
LPLPTHPFPYSRLPH

MAP3K14

251

Q99558
LPLPPAHRLRYLSPA

FAM83E

431

Q2M2I3
YITLPRDLHHAPLLP

SPPL2C

46

Q8IUH8
PRKSPLPSLLHNLYP

MPDZ

1246

O75970
SPLHPPLPSLLLYLL

SIRPD

6

Q9H106
HLLLDPTHELPPYTP

TRERF1

696

Q96PN7