Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	endocytic hemoglobin import into cell	LRP2 CUBN	1.04e-05	2	67	2	GO:0020028
GeneOntologyBiologicalProcess	extraocular skeletal muscle development	MYOM1 MYOM2	1.03e-04	5	67	2	GO:0002074
GeneOntologyBiologicalProcess	developmental process involved in reproduction	FSIP2 SERPINB5 SPEM3 PSME4 TIAL1 DACH2 RBP4 LRP2 SPDYA PRKDC TRIP13 PIAS1 DICER1	1.46e-04	1235	67	13	GO:0003006
GeneOntologyBiologicalProcess	cellular anatomical entity morphogenesis	ABCA2 MYOM1 MYOM2 NEB DICER1	1.54e-04	156	67	5	GO:0032989
GeneOntologyBiologicalProcess	cellular component assembly involved in morphogenesis	ABCA2 MYOM1 MYOM2 NEB DICER1	1.54e-04	156	67	5	GO:0010927
GeneOntologyBiologicalProcess	positive regulation of response to type II interferon	HPX NLRC5	1.55e-04	6	67	2	GO:0060332
GeneOntologyBiologicalProcess	positive regulation of type II interferon-mediated signaling pathway	HPX NLRC5	1.55e-04	6	67	2	GO:0060335
GeneOntologyCellularComponent	M band	PPP2R5A MYOM1 MYOM2 NBR1	3.02e-06	31	68	4	GO:0031430
GeneOntologyCellularComponent	A band	PPP2R5A MYOM1 MYOM2 NBR1	2.46e-05	52	68	4	GO:0031672
Domain	TMEM183	TMEM183A TMEM183BP	1.31e-05	2	68	2	IPR026509
Domain	-	ABCA2 SAMD9 NLRC5 DHX32 TRIP13 DICER1 ABCA8 HYDIN OPA1 DNAH11	3.48e-04	746	68	10	3.40.50.300
Domain	ABC_A	ABCA2 ABCA8	8.42e-04	12	68	2	IPR026082
Domain	P-loop_NTPase	ABCA2 SAMD9 NLRC5 DHX32 TRIP13 DICER1 ABCA8 HYDIN OPA1 DNAH11	9.41e-04	848	68	10	IPR027417
Domain	AAA+_ATPase	ABCA2 TRIP13 ABCA8 DNAH11	1.88e-03	144	68	4	IPR003593
Domain	AAA	ABCA2 TRIP13 ABCA8 DNAH11	1.88e-03	144	68	4	SM00382
Domain	RNaseH-like_dom	ZBED4 PRPF8 FAM200B	2.04e-03	69	68	3	IPR012337
Domain	Pentatricopeptide_repeat	IFT140 PRKDC	3.15e-03	23	68	2	IPR002885
Domain	EGF_CA	LRP2 ADGRE5 CUBN	3.81e-03	86	68	3	PF07645
Domain	EGF_Ca-bd_CS	LRP2 ADGRE5 CUBN	5.33e-03	97	68	3	IPR018097
Domain	EGF_CA	LRP2 ADGRE5 CUBN	5.64e-03	99	68	3	PS01187
Domain	ASX_HYDROXYL	LRP2 ADGRE5 CUBN	5.80e-03	100	68	3	PS00010
Domain	Serpin_CS	SERPINB5 SERPINB1	6.04e-03	32	68	2	IPR023795
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP2 ADGRE5 CUBN	6.82e-03	106	68	3	IPR000152
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	OXA1L RPS3A PPFIBP1 SUPT16H HNRNPM GEMIN4 ZNF638 SERPINB1 PRKDC EIF2A PRPF8 TRIP13 NBR1 STAG2 OPA1 TARS1	1.29e-08	1415	69	16	28515276
Pubmed	CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.	RPS3A PPFIBP1 SUPT16H HNRNPM GEMIN4 LRP2 OS9 BCL2A1 PRKDC	1.44e-07	418	69	9	35338135
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	LRIG3 IFT140 PPP2R5A ING3 ATP7B SUPT16H HNRNPM LRP2 TRIP13 DICER1 ABCA8 OPA1 UNC80	2.60e-07	1116	69	13	31753913
Pubmed	Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.	RPS3A HNRNPM PRKDC PRPF8	2.80e-07	28	69	4	19596686
Pubmed	Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology.	MYOM1 MYOM2 NEB	8.88e-07	10	69	3	20368620
Pubmed	Molecular diversity of myofibrillar proteins: gene regulation and functional significance.	MYOM1 MYOM2 NEB	1.62e-06	12	69	3	8618961
Pubmed	Defining the membrane proteome of NK cells.	ABCA2 ATP7B BZW2 HNRNPM GEMIN4 SERPINB1 ADGRE5 PRKDC PRPF8 NBR1 STAG2 OPA1	2.93e-06	1168	69	12	19946888
Pubmed	Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation.	RPS3A SUPT16H HNRNPM PRKDC PRPF8	3.02e-06	112	69	5	28416769
Pubmed	Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.	RPS3A SUPT16H HNRNPM PRKDC PRPF8 TRIP13	3.53e-06	206	69	6	22174317
Pubmed	Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo.	LRP2 CUBN	3.88e-06	2	69	2	15616221
Pubmed	Role of megalin and cubilin in the metabolism of vitamin D(3).	LRP2 CUBN	3.88e-06	2	69	2	21595846
Pubmed	Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation.	LRP2 CUBN	3.88e-06	2	69	2	23978537
Pubmed	Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup.	TMEM183A TMEM183BP	3.88e-06	2	69	2	16644869
Pubmed	Polymorphisms in LRP2 and CUBN genes and their association with serum vitamin D levels and sleep apnea.	LRP2 CUBN	3.88e-06	2	69	2	38008818
Pubmed	Differential distribution of cubilin and megalin expression in the mouse embryo.	LRP2 CUBN	3.88e-06	2	69	2	14983511
Pubmed	Megalin and cubilin in the human gallbladder epithelium.	LRP2 CUBN	3.88e-06	2	69	2	18791690
Pubmed	Megalin and cubilin: multifunctional endocytic receptors.	LRP2 CUBN	3.88e-06	2	69	2	11994745
Pubmed	Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins.	LRP2 CUBN	3.88e-06	2	69	2	10766831
Pubmed	Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy.	LRP2 CUBN	3.88e-06	2	69	2	11595644
Pubmed	Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney.	LRP2 CUBN	3.88e-06	2	69	2	22437417
Pubmed	Association Analysis of the Cubilin (CUBN) and Megalin (LRP2) Genes with ESRD in African Americans.	LRP2 CUBN	3.88e-06	2	69	2	27197912
Pubmed	TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer.	PRKDC TRIP13	3.88e-06	2	69	2	25078033
Pubmed	Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein.	LRP2 CUBN	3.88e-06	2	69	2	9334227
Pubmed	Silencing megalin and cubilin genes inhibits myeloma light chain endocytosis and ameliorates toxicity in human renal proximal tubule epithelial cells.	LRP2 CUBN	3.88e-06	2	69	2	18448595
Pubmed	Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing.	PSME4 OPA1	3.88e-06	2	69	2	33562813
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RPS3A SUPT16H HNRNPM GEMIN4 PRKDC IDE PRPF8 TRIP13 DICER1 NBR1 STAG2 OPA1 TARS1	3.95e-06	1425	69	13	30948266
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	RPS3A SUPT16H HNRNPM GEMIN4 PRKDC PRPF8 TRIP13 STAG2 TARS1	4.73e-06	638	69	9	33239621
Pubmed	The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.	RPS3A SUPT16H HNRNPM PRPF8 DICER1 STAG2	5.14e-06	220	69	6	34091597
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	TIAL1 RPS3A HNRNPM GEMIN4 ZNF638 PRKDC PRPF8	5.15e-06	340	69	7	24332808
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	OXA1L RPS3A HNRNPM GEMIN4 OS9 PRKDC PRPF8 TRIP13 OPA1	5.99e-06	657	69	9	36180527
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	BDP1 TIAL1 HPX MYOM2 NEB PRPF8 HYDIN OPA1	6.40e-06	497	69	8	36774506
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	BDP1 PPP2R5A OXA1L ZNF638 MYOM2 ZNF221 CUBN NEB NDUFB6 DICER1 HYDIN MCOLN3	8.23e-06	1293	69	12	15342556
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	BZW2 RPS3A PPFIBP1 HNRNPM GEMIN4 PRKDC EIF2A OPA1 TARS1	1.09e-05	708	69	9	39231216
Pubmed	Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells.	LRP2 CUBN	1.16e-05	3	69	2	37126375
Pubmed	Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules.	LRP2 CUBN	1.16e-05	3	69	2	15342463
Pubmed	Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).	LRP2 CUBN	1.16e-05	3	69	2	11717447
Pubmed	Tuberculosis risk is associated with genetic polymorphisms in the LRP2, CUBN, and VDR genes.	LRP2 CUBN	1.16e-05	3	69	2	32803705
Pubmed	Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation.	LRP2 CUBN	1.16e-05	3	69	2	16787536
Pubmed	Multiligand endocytosis and congenital defects: roles of cubilin, megalin and amnionless.	LRP2 CUBN	1.16e-05	3	69	2	17979745
Pubmed	Mouse model of proximal tubule endocytic dysfunction.	LRP2 CUBN	1.16e-05	3	69	2	21926402
Pubmed	Reduced proximal tubular expression of protein endocytic receptors in proteinuria is associated with urinary receptor shedding.	LRP2 CUBN	1.16e-05	3	69	2	29186471
Pubmed	Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex.	LRP2 CUBN	1.16e-05	3	69	2	18400109
Pubmed	Cubilin is essential for albumin reabsorption in the renal proximal tubule.	LRP2 CUBN	1.16e-05	3	69	2	20798259
Pubmed	Megalin dependent urinary cystatin C excretion in ischemic kidney injury in rats.	LRP2 CUBN	1.16e-05	3	69	2	28575050
Pubmed	A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney.	LRP2 CUBN	1.16e-05	3	69	2	11278724
Pubmed	Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules.	LRP2 CUBN	1.16e-05	3	69	2	12815097
Pubmed	Impaired endocytosis in proximal tubule from subchronic exposure to cadmium involves angiotensin II type 1 and cubilin receptors.	LRP2 CUBN	1.16e-05	3	69	2	24093454
Pubmed	Distinct functions of megalin and cubilin receptors in recovery of normal and nephrotic levels of filtered albumin.	LRP2 CUBN	1.16e-05	3	69	2	32200668
Pubmed	Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.	LRP2 CUBN	1.16e-05	3	69	2	10811843
Pubmed	Human parietal epithelial cells (PECs) and proteinuria in lupus nephritis: a role for ClC-5, megalin, and cubilin?	LRP2 CUBN	1.16e-05	3	69	2	37594671
Pubmed	The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins.	MYOM1 MYOM2	1.16e-05	3	69	2	7505783
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	MED24 BZW2 HNRNPM GEMIN4 PRKDC TRIP13 NBR1 STAG2 OPA1 TARS1	1.62e-05	942	69	10	31073040
Pubmed	Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.	SUPT16H GEMIN4 PRKDC	1.67e-05	25	69	3	15385968
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	RPS3A HNRNPM GEMIN4 PRKDC PRPF8 TRIP13 OPA1	1.68e-05	408	69	7	33766124
Pubmed	Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.	BZW2 RPS3A HNRNPM PRKDC IDE PRPF8	1.68e-05	271	69	6	26816005
Pubmed	RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.	CMTR1 RPS3A SUPT16H HNRNPM PRKDC PRPF8 TRIP13	2.18e-05	425	69	7	21081503
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	RPS3A HNRNPM ZNF638 PRPF8 STAG2	2.30e-05	170	69	5	16159877
Pubmed	Selective autophagy degrades DICER and AGO2 and regulates miRNA activity.	GEMIN4 DICER1	2.32e-05	4	69	2	23143396
Pubmed	Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries.	HYDIN DNAH11	2.32e-05	4	69	2	36140829
Pubmed	Abolishment of proximal tubule albumin endocytosis does not affect plasma albumin during nephrotic syndrome in mice.	LRP2 CUBN	2.32e-05	4	69	2	29032953
Pubmed	Dicer is essential for mouse development.	TBXT DICER1	2.32e-05	4	69	2	14528307
Pubmed	Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein.	MYOM1 MYOM2	2.32e-05	4	69	2	12972258
Pubmed	Nestin is expressed during development and in myotendinous and neuromuscular junctions in wild type and desmin knock-out mice.	MYOM1 MYOM2	2.32e-05	4	69	2	10438587
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	TMEM183A BZW2 PPFIBP1 SUPT16H GEMIN4 OS9 DHX32 PRKDC PRPF8 TRIP13 DICER1 STAG2	2.40e-05	1440	69	12	30833792
Pubmed	Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.	HNRNPM PRKDC PRPF8	2.92e-05	30	69	3	21575865
Pubmed	Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy.	RPS3A HNRNPM PRKDC	2.92e-05	30	69	3	35152003
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	TIAL1 RPS3A SUPT16H ZNF638 PRKDC PRPF8 TRIP13 DICER1 STAG2 TARS1	3.30e-05	1024	69	10	24711643
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	SAMD9 RPS3A PPFIBP1 SUPT16H HNRNPM GEMIN4 ZNF638 PRKDC EIF2A PRPF8 TARS1	3.51e-05	1257	69	11	36526897
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	OXA1L PSME4 TIAL1 RPS3A HNRNPM GEMIN4 PRKDC PRPF8 TRIP13 OPA1 TARS1	3.51e-05	1257	69	11	37317656
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	CMTR1 TMEM183A TIAL1 HNRNPM ZNF638 TMEM183BP DICER1	3.70e-05	462	69	7	31138677
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	RPS3A HNRNPM PRKDC PRPF8 TRIP13 STAG2 TARS1	3.75e-05	463	69	7	34901782
Pubmed	Myomesin 3, a novel structural component of the M-band in striated muscle.	MYOM1 MYOM2	3.86e-05	5	69	2	18177667
Pubmed	Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein.	LRP2 CUBN	3.86e-05	5	69	2	16263760
Pubmed	MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3.	PRKDC DICER1	3.86e-05	5	69	2	20956382
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	RPS3A PPFIBP1 HNRNPM PRKDC EIF2A PRPF8 PIAS1 DICER1	3.88e-05	639	69	8	23443559
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	RPS3A HNRNPM SERPINB1 DHX32 PRKDC NEB PRPF8 OPA1 TARS1	4.31e-05	844	69	9	25963833
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	BZW2 SUPT16H HNRNPM ZNF638 PRPF8	4.42e-05	195	69	5	19454010
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	SERPINB5 RPS3A SUPT16H HNRNPM ZNF638 PRKDC PRPF8 STAG2	4.47e-05	652	69	8	31180492
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	IFT140 PSME4 LRP2 DNAH11	4.82e-05	100	69	4	25807483
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	HNRNPM ZNF638 PRKDC PRPF8 TRIP13 STAG2	5.23e-05	332	69	6	32786267
Pubmed	Establishment of cardiac cytoarchitecture in the developing mouse heart.	MYOM1 MYOM2	5.79e-05	6	69	2	16337936
Pubmed	The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.	LRP2 CUBN	5.79e-05	6	69	2	19177150
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	ABCA2 RPS3A SUPT16H HNRNPM ZNF638 DHX32 PRKDC PRPF8 DICER1 OPA1 TARS1	6.04e-05	1335	69	11	29229926
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PSME4 RPS3A SUPT16H HNRNPM GEMIN4 ZNF638 PRKDC EIF2A PRPF8 TRIP13 TARS1	6.81e-05	1353	69	11	29467282
Pubmed	Quantitative nanoproteomics for protein complexes (QNanoPX) related to estrogen transcriptional action.	RPS3A HNRNPM PRKDC	7.55e-05	41	69	3	19805454
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	SUPT16H HNRNPM PRKDC PRPF8 PIAS1	7.82e-05	220	69	5	35785414
Pubmed	Vitamin D.	LRP2 CUBN	8.09e-05	7	69	2	15951480
Pubmed	Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.	PSME4 ARHGAP25 NBR1	8.12e-05	42	69	3	7584044
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	ZBED4 BZW2 SUPT16H HNRNPM ZNF638 DHX32 PRPF8 NDUFB6 FAM200B	8.49e-05	922	69	9	27609421
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	TIAL1 RPS3A HNRNPM PRKDC EIF2A PRPF8 TRIP13 OPA1	9.36e-05	725	69	8	27025967
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	HNRNPM PRKDC PRPF8 TRIP13	9.80e-05	120	69	4	27320910
Pubmed	USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage.	RPS3A LRP2 OS9	9.99e-05	45	69	3	35605301
Pubmed	CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function.	MYOM1 MYOM2	1.08e-04	8	69	2	20215401
Pubmed	Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes.	GEMIN4 DICER1	1.08e-04	8	69	2	20211803
Pubmed	Mechanisms of translational regulation by a human eIF5-mimic protein.	BZW2 EIF2A	1.08e-04	8	69	2	21745818
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	TIAL1 ZBED4 SUPT16H HNRNPM MYOM2 PRKDC NEB PRPF8 TRIP13 STAG2 DOP1A	1.20e-04	1442	69	11	35575683
Pubmed	Systematic analyses of the ultraviolet radiation resistance-associated gene product (UVRAG) protein interactome by tandem affinity purification.	HNRNPM PRKDC TRIP13	1.21e-04	48	69	3	26590968
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	BZW2 GEMIN4 OS9 PRKDC IDE EIF2A PRPF8 DICER1 OPA1	1.28e-04	974	69	9	28675297
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	SUPT16H HNRNPM PRKDC PRPF8	1.37e-04	131	69	4	34551306
Pubmed	Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.	ABCA2 ABCA8	1.38e-04	9	69	2	21707071
Interaction	TNFSF13B interactions	LRIG3 BZW2 PPFIBP1 GEMIN4 PRKDC TRIP13	2.78e-06	119	67	6	int:TNFSF13B
Interaction	BTNL9 interactions	BZW2 PPFIBP1 GEMIN4 ULBP3 STAG2 EPG5	1.32e-05	156	67	6	int:BTNL9
Interaction	VCP interactions	BZW2 RPS3A PPFIBP1 SUPT16H HPX SERPINB1 OS9 PRKDC NEB PRPF8 TRIP13 DICER1 NBR1 STAG2 ABCA8 CRBN	1.40e-05	1435	67	16	int:VCP
Interaction	GSK3B interactions	MED24 SAMD9 BZW2 PPFIBP1 HNRNPM GEMIN4 BCL2A1 PRKDC PIAS1 DICER1 NBR1 CRBN	2.55e-05	868	67	12	int:GSK3B
Interaction	KCNA3 interactions	CMTR1 BZW2 RPS3A PPFIBP1 HNRNPM GEMIN4 LRP2 PRKDC EIF2A OPA1 TARS1 DOP1A	2.64e-05	871	67	12	int:KCNA3
Interaction	GPR17 interactions	BZW2 PPFIBP1 GEMIN4 PRKDC STAG2 OPA1 DOP1A	4.23e-05	283	67	7	int:GPR17
Interaction	DYSF interactions	MYOM1 OS9 MYOM2 NEB	5.38e-05	62	67	4	int:DYSF
Interaction	MTF1 interactions	RPS3A SUPT16H HNRNPM PRKDC PRPF8	5.57e-05	123	67	5	int:MTF1
Interaction	DHX9 interactions	CMTR1 ZBED4 RPS3A SUPT16H HNRNPM GEMIN4 PRKDC PRPF8 PIAS1 DICER1	6.26e-05	662	67	10	int:DHX9
Interaction	B3GNT2 interactions	RPS3A PPFIBP1 SUPT16H HNRNPM GEMIN4 LRP2 OS9 PRKDC EIF2A	7.35e-05	542	67	9	int:B3GNT2
Interaction	DUX4 interactions	BZW2 RPS3A HNRNPM PRKDC IDE PRPF8	7.78e-05	214	67	6	int:DUX4
Interaction	SFN interactions	SERPINB5 RPS3A PPFIBP1 SUPT16H HNRNPM ZNF638 NEB PRPF8 PIAS1 DOP1A	9.04e-05	692	67	10	int:SFN
Interaction	DDX5 interactions	CMTR1 HNRNPM PRKDC EIF2A PRPF8 PIAS1 NBR1 STAG2 CRBN	1.05e-04	568	67	9	int:DDX5
Interaction	SUMO2 interactions	SUPT16H HNRNPM ZNF638 PRKDC PRPF8 TRIP13 PIAS1 STAG2 ABCA8	1.42e-04	591	67	9	int:SUMO2
Interaction	SRRM1 interactions	CMTR1 SUPT16H HNRNPM ZNF638 PRKDC PRPF8 STAG2	1.54e-04	348	67	7	int:SRRM1
Interaction	PTP4A3 interactions	HNRNPM MYOM2 ULBP3 DICER1 MCOLN3	1.61e-04	154	67	5	int:PTP4A3
Interaction	EIF2S2 interactions	SERPINB5 CMTR1 PRKDC EIF2A PRPF8 TARS1	1.70e-04	247	67	6	int:EIF2S2
GeneFamily	Fibronectin type III domain containing\|I-set domain containing\|Myosin binding proteins	MYOM1 MYOM2	1.83e-04	8	47	2	658
GeneFamily	ATP binding cassette subfamily A	ABCA2 ABCA8	5.90e-04	14	47	2	805
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 GRIK3 MYOM2 NEB HYDIN UNC80 DNAH11	1.34e-08	184	68	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 GRIK3 MYOM2 NEB HYDIN UNC80 DNAH11	1.34e-08	184	68	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 GRIK3 MYOM2 NEB HYDIN UNC80 DNAH11	1.34e-08	184	68	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 LRP2 CUBN HYDIN UNC80 DNAH11	2.32e-07	169	68	6	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	PPFIBP1 RBP4 LRP2 CUBN HYDIN	9.17e-06	184	68	5	51ed1ebfdef45149541917c66cbacad87072e51f
Disease	whole-brain volume	CUBN DNAH11	5.21e-05	5	68	2	EFO_0005089
Disease	Proteinuria	LRP2 CUBN	5.39e-04	15	68	2	HP_0000093
Disease	urate measurement, bone density	FSIP2 PPFIBP1 ARHGAP25 PRKDC ABCA8 CRBN DNAH11	5.54e-04	619	68	7	EFO_0003923, EFO_0004531
Disease	Malignant neoplasm of breast	SERPINB5 ATP7B NLRC5 DHX32 GRIK3 BCL2A1 CUBN DOP1A EPG5	7.77e-04	1074	68	9	C0006142
Disease	Lung diseases	ADGRE5 PRKDC DNAH11	7.87e-04	78	68	3	C0024115
Disease	mean corpuscular hemoglobin concentration	IFT140 SAMD9 ATP7B BZW2 ZNF638 DHX32 PRKDC NEB TRIP13	9.50e-04	1105	68	9	EFO_0004528
Disease	Dyslipidemias	ATP7B DNAH11	1.40e-03	24	68	2	C0242339
Disease	Dyslipoproteinemias	ATP7B DNAH11	1.40e-03	24	68	2	C0598784
Disease	retinitis pigmentosa (implicated_via_orthology)	PRPF8 EPG5	1.77e-03	27	68	2	DOID:10584 (implicated_via_orthology)
Disease	Retinitis Pigmentosa	IFT140 RBP4 PRPF8	1.81e-03	104	68	3	C0035334
Disease	bone density	ING3 DACH2 ZNF283 SPDYA ARHGAP25	2.03e-03	388	68	5	EFO_0003923
Disease	Bilateral Wilms Tumor	TRIP13 DICER1	2.04e-03	29	68	2	C2930471
Disease	Hematopoetic Myelodysplasia	SAMD9 STAG2	2.04e-03	29	68	2	C2713368

Protein segments in the cluster

Peptide	Gene	Start	Entry
SAFWMKVKEDFPLLS	FAM200B	581	P0CF97
LSKMDFKSFGLFSKW	EPG5	1906	Q9HCE0
FAVKLFKAWMAEKDA	BZW2	186	Q9Y6E2
KPWSNKETDMFFLAI	BDP1	301	A6H8Y1
TRAWEPAMKKSFAFD	ATP7B	26	P35670
WKLTQKFSEINPDMK	ADGRE5	716	P48960
KFTATKKDMSPQKFW	CRBN	401	Q96SW2
DSWFKVDMKPFKVSL	DNAH11	1106	Q96DT5
KKFEPKSGWMTFLEV	BCL2A1	146	Q16548
AWKKEAFDLFMDPSF	DOP1A	2106	Q5JWR5
DSAYEWKMPKKSSLG	DICER1	1476	Q9UPY3
SITKKMPEWVLFHKF	DHX32	656	Q7L7V1
ESSWDKDKMQSPFAA	DACH2	261	Q96NX9
KLKFFFMNPCEKFWA	MCOLN3	41	Q8TDD5
SNSDLDMPFAKWTKE	PPFIBP1	636	Q86W92
SDSPMTFAWKKDNEL	LRIG3	526	Q6UXM1
KWKSIVMAFSGNKDF	LIPJ	186	Q5W064
PFDFTWKMLKDKFNE	HNRNPM	661	P52272
NKYPLKTWFDSEKKM	FSIP2	1216	Q5CZC0
FFMNAKKNKPEWREE	ING3	46	Q9NXR8
GPMEKFWNKFLENKS	NDUFB6	41	O95139
FTDWTKMAVLKANKF	LRP2	616	P98164
FLESFKKGWKNAEMT	OXA1L	361	Q15070
KRAPQMDWSKKNELF	SLC9A3R1	341	O14745
LTKDPEWLNAKMKFF	NLRC5	21	Q86WI3
WFSESGKLVTKMFQK	TRIP13	221	Q15645
KKTFDQWKDMIPDLS	OPA1	116	O60313
VFKTDSFQTAKGWKM	CUBN	3131	O60494
SWTKEEISSMKPKEF	HYDIN	626	Q4G0P3
AKIGQFDKMKSPFEW	ABCA2	1971	Q9BZC7
WKDKFMKEATTNAPF	SERPINB1	171	P30740
MSKLWFKQDDKFFLP	IDE	556	P14735
KSFFKADKVTMLWNK	EIF2A	216	Q9BY44
FKKSKISTFEKMWAF	GRIK3	696	Q13003
GDEKALDMFNWKKSS	IFT140	176	Q96RY7
EPWTMGFSKSFKKKF	CMTR1	756	Q8N1G2
TMLFFKGEFVWKSHK	HPX	66	P02790
SFPDPKMLKEWEKFQ	TARS1	301	P26639
TNFLKKDKSMEWFTG	SPDYA	296	Q5MJ70
TGNVKWSADTKLKFM	NBR1	401	Q14596
SKKDWYDVKAPAMFN	RPS3A	26	P61247
EPMWEFNFKFKKQSP	TMEM183BP	251	Q1AE95
NKKAFWGTEKFEDKM	SAMD9	946	Q5K651
NMKKFFPKGATWDIL	MED24	26	O75448
WMKKFSESETKECPF	SERPINB5	171	P36952
QFKEDGTWAPMRSKK	PIAS1	406	O75925
VFSKDKFPGEFMKSW	SUPT16H	136	Q9Y5B9
PTKDDSKDSDFWKML	OS9	301	Q13438
EWKFGKKSMRKDPFF	ABCA8	1221	O94911
KFWPKTCSQKEVMFL	PPP2R5A	316	Q15172
ASGFEESMKWKKLTN	PRPF8	1506	Q6P2Q9
EKWEKDSGLTTFFKM	ULBP3	171	Q9BZM4
KDFWRKMFKSQSAAS	UNC80	1026	Q8N2C7
EPMWEFNFKFKKQSP	TMEM183A	251	Q8IXX5
MEWKNSDDAKDKFPQ	SPEM3	521	A0A1B0GUW6
LTMAGPQWKKFKSSF	STAG2	161	Q8N3U4
TDTEDPAKFKMKYWG	RBP4	96	P02753
KMEIFKNEFWSPSSE	ARHGAP25	461	P42331
WMKAPVSFSKVKLTN	TBXT	136	O15178
FDSRWKSFNLVKKSM	PSME4	911	Q14997
VKEPSFDWKNFEQKM	PRKDC	4006	P78527
FLGKEKFWKMKTTSQ	ZNF221	81	Q9UK13
DWMAKQASLDFFVKK	ZBED9	686	Q6R2W3
FLQGKKPMWSQLFKD	ZBED9	1081	Q6R2W3
KCYWGKESPDMTKNF	TIAL1	271	Q01085
SWLPKFSHADAQKMK	ZNF638	391	Q14966
FEINFSQWEMKDKSK	ZNF283	131	Q8N7M2
NMSSRKKSPAWKHFF	ZBED4	111	O75132
VWMKFSTPKEEKQFL	GEMIN4	611	P57678
DKMTPKSEFSWSKDY	MYOM1	1161	P52179
VLLKESKWTKMFFGE	MYOM2	321	P54296
EKWKTKFSSPVDMLG	NEB	2351	P20929
FEKWKTKFSSPVDML	NEB	2836	P20929
EKWKTKFSSPVDMLG	NEB	3566	P20929