Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE1A PDE4A PDE4C PDE6G	5.28e-05	24	175	4	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE1A PDE4A PDE4C PDE6G	6.24e-05	25	175	4	GO:0004114
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE1A PDE4A PDE4C PDE6G	8.55e-05	27	175	4	GO:0004112
HumanPheno	Midline defect of the nose	FRMPD4 FREM1 LONP1 NSMF FZD2	1.55e-05	30	56	5	HP:0004122
Domain	SAM/pointed	STARD13 KIF24 TFCP2 TFCP2L1 DLC1 CASKIN2 TNKS2 ARAP2	1.39e-05	117	174	8	IPR013761
Domain	LON_substr_bdg	LONP1 LONRF3 LONRF2	1.56e-05	6	174	3	PF02190
Domain	LON	LONP1 LONRF3 LONRF2	1.56e-05	6	174	3	SM00464
Domain	LON_N	LONP1 LONRF3 LONRF2	1.56e-05	6	174	3	PS51787
Domain	LON_substr-bd_dom	LONP1 LONRF3 LONRF2	1.56e-05	6	174	3	IPR003111
Domain	FRI	MFRP FZD1 FZD7 FZD2	3.14e-05	20	174	4	SM00063
Domain	-	MFRP FZD1 FZD7 FZD2	3.85e-05	21	174	4	1.10.2000.10
Domain	Spectrin	KALRN SYNE1 SPTBN2 DST	5.61e-05	23	174	4	PF00435
Domain	Frizzled_dom	MFRP FZD1 FZD7 FZD2	6.68e-05	24	174	4	IPR020067
Domain	FZ	MFRP FZD1 FZD7 FZD2	6.68e-05	24	174	4	PS50038
Domain	Fz	MFRP FZD1 FZD7 FZD2	6.68e-05	24	174	4	PF01392
Domain	Frizzled	FZD1 FZD7 FZD2	1.24e-04	11	174	3	IPR000539
Domain	Frizzled	FZD1 FZD7 FZD2	1.24e-04	11	174	3	PF01534
Domain	Frizzled	FZD1 FZD7 FZD2	1.24e-04	11	174	3	SM01330
Domain	Spectrin_repeat	KALRN SYNE1 SPTBN2 DST	1.44e-04	29	174	4	IPR002017
Domain	TPR_REGION	TTC28 TTC3 TTC29 VPS13A CFAP70 LONRF3 LONRF2 CFAP46	1.60e-04	165	174	8	PS50293
Domain	TPR	TTC28 TTC3 TTC29 VPS13A CFAP70 LONRF3 LONRF2 CFAP46	1.60e-04	165	174	8	PS50005
Domain	SPEC	KALRN SYNE1 SPTBN2 DST	2.13e-04	32	174	4	SM00150
Domain	Spectrin/alpha-actinin	KALRN SYNE1 SPTBN2 DST	2.13e-04	32	174	4	IPR018159
Domain	SAM_DOMAIN	STARD13 KIF24 DLC1 CASKIN2 TNKS2 ARAP2	2.63e-04	95	174	6	PS50105
Domain	SAM	STARD13 KIF24 DLC1 CASKIN2 TNKS2 ARAP2	2.94e-04	97	174	6	IPR001660
Domain	Frizzled/SFRP	FZD1 FZD7 FZD2	4.07e-04	16	174	3	IPR015526
Domain	TM_Fragile-X-F-assoc	TMEM185B TMEM185A	5.11e-04	4	174	2	IPR019396
Domain	Tmemb_185A	TMEM185B TMEM185A	5.11e-04	4	174	2	PF10269
Domain	Neurhyp_horm	LONRF3 LONRF2	5.11e-04	4	174	2	IPR000981
Domain	TPR-contain_dom	TTC28 TTC3 TTC29 VPS13A CFAP70 LONRF3 LONRF2	5.20e-04	150	174	7	IPR013026
Domain	PDEase	PDE1A PDE4A PDE4C	6.90e-04	19	174	3	IPR023088
Domain	PUA-like_domain	LONP1 LONRF3 LONRF2	6.90e-04	19	174	3	IPR015947
Domain	-	VPS11 TTC28 TTC3 TTC29 CFAP70 LONRF3 LONRF2 CFAP46	7.33e-04	207	174	8	1.25.40.10
Domain	C2_dom	UNC13B TNS2 OTOF PIK3C2G HECW2 PLCH1 RASAL1	8.81e-04	164	174	7	IPR000008
Domain	PDEase_I	PDE1A PDE4A PDE4C	9.34e-04	21	174	3	PF00233
Domain	PDEASE_I	PDE1A PDE4A PDE4C	9.34e-04	21	174	3	PS00126
Domain	PDEase_CS	PDE1A PDE4A PDE4C	9.34e-04	21	174	3	IPR023174
Domain	-	PDE1A PDE4A PDE4C	1.07e-03	22	174	3	1.10.1300.10
Domain	ACTININ_2	SYNE1 SPTBN2 DST	1.23e-03	23	174	3	PS00020
Domain	ACTININ_1	SYNE1 SPTBN2 DST	1.23e-03	23	174	3	PS00019
Domain	Actinin_actin-bd_CS	SYNE1 SPTBN2 DST	1.23e-03	23	174	3	IPR001589
Domain	PDEase_catalytic_dom	PDE1A PDE4A PDE4C	1.23e-03	23	174	3	IPR002073
Domain	HELP	EML6 EML5	1.26e-03	6	174	2	PF03451
Domain	CP2	TFCP2 TFCP2L1	1.26e-03	6	174	2	PF04516
Domain	CP2	TFCP2 TFCP2L1	1.26e-03	6	174	2	IPR007604
Domain	HELP	EML6 EML5	1.26e-03	6	174	2	IPR005108
Domain	TPR	TTC28 TTC3 TTC29 CFAP70 LONRF3 LONRF2	1.33e-03	129	174	6	SM00028
Domain	HD/PDEase_dom	PDE1A PDE4A PDE4C	1.39e-03	24	174	3	IPR003607
Domain	HDc	PDE1A PDE4A PDE4C	1.39e-03	24	174	3	SM00471
Domain	C2	UNC13B OTOF PIK3C2G HECW2 PLCH1 RASAL1	1.43e-03	131	174	6	PF00168
Domain	TPR_repeat	TTC28 TTC3 TTC29 CFAP70 LONRF3 LONRF2	1.55e-03	133	174	6	IPR019734
Domain	TPR-like_helical_dom	VPS11 TTC28 TTC3 TTC29 CFAP70 LONRF3 LONRF2 CFAP46	1.56e-03	233	174	8	IPR011990
Domain	C2	UNC13B OTOF PIK3C2G HECW2 PLCH1 RASAL1	1.80e-03	137	174	6	SM00239
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	UNC13B PALD1 CLSTN3 FRMPD4 TTC28 SYNE1 CSMD3 VIRMA TENM4 FAF2 MROH1 SEC24C ZNF644 SLIT1 SEC16A CAMTA1 KIF17 ADGRL3 ARAP2	4.60e-13	407	179	19	12693553
Pubmed	Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.	FZD1 FZD7 FZD2	1.34e-07	3	179	3	9813155
Pubmed	Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.	FZD1 FZD7 FZD2	1.34e-07	3	179	3	27680706
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CENPC PMPCB PEG10 SYNE1 SPTBN2 SPART SEC22B TTC3 DEGS1 TFCP2 PNPLA6 FAF2 DPP9 DNAJC10 SEC24C GTF3C2 CASKIN2 NT5DC2 RRP9 ZNF644 VPS13A ITM2C PLCH1 NEURL4 ZC3HAV1	2.02e-07	1487	179	25	33957083
Pubmed	Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.	PRICKLE1 FZD1 FZD7 FZD2	4.68e-07	13	179	4	21246654
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	MYH7 KALRN SGCB PEG10 SYNE1 SPART TTC3 AKR1C2 ZNF462 DST ADAMTS9 LONRF3 TNKS2	2.05e-06	497	179	13	23414517
Pubmed	FZD2 regulates limb development by mediating β-catenin-dependent and -independent Wnt signaling pathways.	FZD1 FZD7 FZD2	2.65e-06	6	179	3	36867021
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	VPS11 PMPCB RNF19A SGCB PEG10 SMCHD1 EXT1 ACVR1B DEGS1 FAF2 MROH1 ANGPT4 VPS13A SEC16A ITM2C EEA1 RMND1 PCDH9 RAD17	2.67e-06	1061	179	19	33845483
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	UNC13B CLSTN3 ZNF234 TTC28 KALRN PEG10 SYNE1 SPTBN2 TTC3 NFE2L3 MFGE8 DST NSMF OTOF ADAMTS9 KRT222 OSBPL1A N4BP2L2 ZNF76 TBC1D23 TNKS2	3.23e-06	1285	179	21	35914814
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	SPG7 TTC28 PMPCB SPART GCDH PDCD2L PNPLA6 FAF2 DPP9 DNAJC10 VPS13A ITM2C VDAC3 ZC3HAV1	3.48e-06	606	179	14	36538041
Pubmed	Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.	FZD1 FZD7 FZD2	7.37e-06	8	179	3	19388021
Pubmed	Overview of PDEs and their regulation.	PDE1A PDE4A PDE4C PDE6G	7.89e-06	25	179	4	17307970
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE1A PDE4A PDE4C PIK3C2G	1.09e-05	27	179	4	11156964
Pubmed	Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.	FZD1 FZD7 FZD2	1.10e-05	9	179	3	23095888
Pubmed	Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.	FZD1 FZD7 FZD2	1.10e-05	9	179	3	12067714
Pubmed	A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.	FZD1 FZD7 FZD2	1.10e-05	9	179	3	9707618
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SIN3B PDE4A KALRN SYNE1 SPTBN2 TTC3 VIRMA ZNF462 WDR91 CCDC88C NCOR2 DST SEC24C FAM120C SEC16A NEURL4 RASAL1	1.11e-05	963	179	17	28671696
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SIN3B TTC28 PHF12 BCORL1 RLF ZNF462 NCOR2 DST GTF3C2 ZNF644 SEC16A	1.21e-05	418	179	11	34709266
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	MYH7B SEC22B CCDC88C FAF2 ANGPT4 MID1 VPS13A POLQ	1.33e-05	208	179	8	33230847
Pubmed	Expression of Frizzled genes in developing and postnatal hair follicles.	FZD1 FZD7 FZD2	1.57e-05	10	179	3	15245425
Pubmed	Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.	FZD1 FZD7 FZD2	1.57e-05	10	179	3	17532316
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	UNC13B PALD1 PDE4A SPG7 KALRN PHF12 TBC1D25 TTC3 FZD1 FZD7 CCDC88C NCOR2 LLGL2 DST PNPLA6 MROH1 SEC16A RASAL1	1.77e-05	1105	179	18	35748872
Pubmed	Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.	FZD1 FZD7 FZD2	2.15e-05	11	179	3	24860427
Pubmed	Molecular determinants of WNT9b responsiveness in nephron progenitor cells.	FZD1 FZD7 FZD2	2.15e-05	11	179	3	30978219
Pubmed	Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.	FZD1 FZD7 FZD2	2.15e-05	11	179	3	17582687
Pubmed	Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.	FZD1 FZD7 FZD2	2.15e-05	11	179	3	17576136
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TTC28 SYNE1 ZNF462 TENM4 DST SLIT1 SEC16A CAMTA1	2.34e-05	225	179	8	12168954
Pubmed	DNA polymerase θ protects leukemia cells from metabolically induced DNA damage.	FLT3 POLQ	2.63e-05	2	179	2	36580665
Pubmed	A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13.	UNC13B SPTBN2	2.63e-05	2	179	2	9704016
Pubmed	Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function.	TNS2 DLC1	2.63e-05	2	179	2	19440389
Pubmed	Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1.	TNS2 DLC1	2.63e-05	2	179	2	20069572
Pubmed	A novel gene, FAM11A, associated with the FRAXF CpG island is transcriptionally silent in FRAXF full mutation.	TMEM185B TMEM185A	2.63e-05	2	179	2	12404111
Pubmed	A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation.	NCOR2 RNF125	2.63e-05	2	179	2	15843525
Pubmed	Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4.	PDE4A PDE4C	2.63e-05	2	179	2	23043089
Pubmed	CRTR-1, a developmentally regulated transcriptional repressor related to the CP2 family of transcription factors.	TFCP2 TFCP2L1	2.63e-05	2	179	2	11073954
Pubmed	Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts.	FZD1 FZD2	2.63e-05	2	179	2	20189955
Pubmed	Modulation of CP2 family transcriptional activity by CRTR-1 and sumoylation.	TFCP2 TFCP2L1	2.63e-05	2	179	2	20661472
Pubmed	Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses.	STARD13 DLC1	2.63e-05	2	179	2	33142932
Pubmed	Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode.	TNS2 DLC1	2.63e-05	2	179	2	22645138
Pubmed	START-GAP1/DLC1 is localized in focal adhesions through interaction with the PTB domain of tensin2.	TNS2 DLC1	2.63e-05	2	179	2	19895840
Pubmed	Fusion driven JMML: a novel CCDC88C-FLT3 fusion responsive to sorafenib identified by RNA sequencing.	FLT3 CCDC88C	2.63e-05	2	179	2	31511612
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	SIN3B USP22 SPTBN2 BCORL1 ACVR1B STOX1 DST ADAMTS9 FAM120C DQX1 HECW2 VPS13A LONRF2 ZNF304	3.05e-05	736	179	14	29676528
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	SYNE1 VIRMA DST OTOF FAM120C EEA1 PLCH1 ZC3HAV1	3.10e-05	234	179	8	36243803
Pubmed	Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.	PMPCB SEC22B ITM2C VDAC3	3.14e-05	35	179	4	9653160
Pubmed	Human transcription factor protein interaction networks.	SIN3B USP22 PHF12 PEG10 SMCHD1 BCORL1 IRF4 SEC22B TFCP2 RLF HOXA5 ZNF462 NCOR2 LONP1 DST GTF3C2 ZNF644 SEC16A VDAC3 ZC3HAV1	5.14e-05	1429	179	20	35140242
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	STARD13 MYH7 CENPC PMPCB MYH7B SYNE1 SMCHD1 SPTBN2 EML6 STOX1 TTC3 NFE2L3 DST DNAJC10 VPS13A EEA1 PLCH1 POLQ CFAP46 VDAC3	5.82e-05	1442	179	20	35575683
Pubmed	Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.	PALD1 SEC22B LYSMD3 DST FAF2 SEC16A ZC3HAV1	6.32e-05	191	179	7	31177093
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	USP22 TTC28 PHF12 GCDH PDCD2L NCOR2 PNPLA6 EML5 DNAJC10 FAM120C INTS13 NT5DC2 SEC16A ITM2C LONRF3 ARAP2 ZNF646	7.01e-05	1116	179	17	31753913
Pubmed	Gene expression analysis of the embryonic subplate.	PDE1A LRRTM3 CSMD3 FZD1 NT5DC2 SLIT1 FZD2	7.44e-05	196	179	7	21862448
Pubmed	TFCP2/TFCP2L1/UBP1 transcription factors in cancer.	TFCP2 TFCP2L1	7.88e-05	3	179	2	29410248
Pubmed	Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters.	FZD1 FZD7	7.88e-05	3	179	2	35296808
Pubmed	Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression.	TNS2 DLC1	7.88e-05	3	179	2	16951145
Pubmed	Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis.	STARD13 DLC1	7.88e-05	3	179	2	20600027
Pubmed	Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.	FZD1 FZD7 FZD2	8.64e-05	17	179	3	28733458
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	PALD1 TTC28 PMPCB SYNE1 GCDH SEC22B TTC3 TFCP2 LONP1 DST FAF2 GTF3C2 NT5DC2 RRP9 ZNF644 VPS13A SEC16A RMND1 NEURL4 ZC3HAV1	9.59e-05	1496	179	20	32877691
Pubmed	Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.	PRICKLE1 FZD1 FZD7 FZD2	1.02e-04	47	179	4	33141892
Pubmed	Hereditary Ataxia Overview	SPG7 SYNE1 SPTBN2 CCDC88C PNPLA6	1.17e-04	92	179	5	20301317
Pubmed	Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.	FZD1 FZD7 FZD2	1.22e-04	19	179	3	21623369
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TTC28 PRICKLE1 PHF12 BCORL1 MC3R TBC1D25 ZNF442 VIRMA NCOR2 FAF2 INTS13 VPS13A	1.26e-04	638	179	12	31182584
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	MYH7 FLT3 SYNE1 CARS1 FREM1 EML5	1.42e-04	152	179	6	34299191
Pubmed	Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.	PDE4A PDE4C	1.57e-04	4	179	2	9371714
Pubmed	Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes.	MFRP FZD1	1.57e-04	4	179	2	16442268
Pubmed	Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.	PDE4A PDE4C	1.57e-04	4	179	2	24732776
Pubmed	Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.	PDE4A PDE4C	1.57e-04	4	179	2	34943270
Pubmed	Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2.	FZD7 FZD2	1.57e-04	4	179	2	18215320
Pubmed	A novel mammalian complex containing Sin3B mitigates histone acetylation and RNA polymerase II progression within transcribed loci.	SIN3B PHF12	1.57e-04	4	179	2	21041482
Pubmed	PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.	PDE4A PDE4C	1.57e-04	4	179	2	32738081
Pubmed	A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.	PDE4A PDE4C	1.57e-04	4	179	2	8413254
Pubmed	Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function.	TTC29 CFAP70	1.57e-04	4	179	2	37934199
Pubmed	Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles.	MYH7 MYH7B	1.57e-04	4	179	2	19948655
Pubmed	Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells.	FZD1 FZD2	1.57e-04	4	179	2	18929644
Pubmed	Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.	PDE4A PDE4C	1.57e-04	4	179	2	22946044
Pubmed	The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT.	FLT3 NCOR2	1.57e-04	4	179	2	14982881
Pubmed	Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.	PDE4A PDE4C	1.57e-04	4	179	2	33609559
Pubmed	Dorsal root ganglion axon bifurcation tolerates increased cyclic GMP levels: the role of phosphodiesterase 2A and scavenger receptor Npr3.	PDE1A NPR3 PDE6G	1.67e-04	21	179	3	27740716
Pubmed	Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.	MALRD1 PLXDC2 KLB	1.67e-04	21	179	3	23747249
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	CLSTN3 SYNE1 DST ZNF432 ADGRL3	1.81e-04	101	179	5	9872452
Pubmed	Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.	FZD1 FZD7 FZD2	1.92e-04	22	179	3	17064353
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	RNMT USP22 FZD7 DPP9 PTPRG SEC16A LONRF3 LONRF2	2.04e-04	307	179	8	37499664
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	USP22 TTC28 PEG10 TNS2 PLCH1	2.08e-04	104	179	5	10470851
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	SIN3B PHF12 SMCHD1 PDCD2L TFCP2 HOXA5 CCDC88C SEC24C GTF3C2 INTS13 ZNF646	2.35e-04	583	179	11	29844126
Pubmed	Genomic analysis of mouse retinal development.	SIN3B FLT3 PDE6G USP22 SPG7 BTBD17 FZD1 FZD7 NCOR2 DST PIK3C2G SLIT1 TNKS2 PLCH1 FZD2	2.38e-04	1006	179	15	15226823
Pubmed	Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women.	FZD1 FZD7	2.61e-04	5	179	2	19543507
Pubmed	The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.	PDE4A PDE4C	2.61e-04	5	179	2	33944911
Pubmed	The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1.	TNS2 DLC1	2.61e-04	5	179	2	17190795
Pubmed	Autocatalytic processing of m-AAA protease subunits in mitochondria.	SPG7 PMPCB	2.61e-04	5	179	2	19656850
Pubmed	A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons.	PDE4A PDE4C	2.61e-04	5	179	2	8586960
Pubmed	Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?	SEMG2 VDAC3	2.61e-04	5	179	2	17683036
Pubmed	Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor.	TMEM185B TMEM185A	2.61e-04	5	179	2	15525354
Pubmed	A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.	VPS11 MYH7 SYNE1 DST	2.64e-04	60	179	4	20682791
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	RNMT SMCHD1 SPTBN2 CARS1 AKR1C2 DST FAF2 SEC24C NT5DC2 SEC16A	2.77e-04	498	179	10	36634849
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	MYH7 SPG7 PMPCB SGCB SYNE1 SPTBN2 SPART SI FZD7 NCOR2 DST PCDH9	2.84e-04	697	179	12	28298427
Pubmed	A role for Wnt/beta-catenin signaling in lens epithelial differentiation.	FZD1 FZD7 FZD2	2.84e-04	25	179	3	12812787
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	SIN3B VRK3 CENPC PHF12 SMCHD1 BCORL1 RLF ZNF462 GTF3C2 ZNF644 PRDM15	3.36e-04	608	179	11	36089195
Pubmed	Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum.	SEC24C SEC16A	3.90e-04	6	179	2	17428803
Pubmed	Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling.	FZD7 FZD2	3.90e-04	6	179	2	20802536
Pubmed	Identification and characterization of Grainyhead-like epithelial transactivator (GET-1), a novel mammalian Grainyhead-like factor.	TFCP2 TFCP2L1	3.90e-04	6	179	2	12666198
Pubmed	Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum.	PDE4A PDE4C	3.90e-04	6	179	2	18923023
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	UNC13B STARD13 VRK3 EFCAB6 PMPCB PEG10 CA14 CPS1 TTC3 MFGE8 DST DLC1 GTF3C2 EEA1 POLQ LRRC36 ZNF304	3.96e-04	1293	179	17	15342556
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	FZD1 FZD7 FZD2	4.44e-04	29	179	3	18364260
Interaction	SCGB1C1 interactions	EXT1 FZD1 FZD7 FZD2	3.95e-06	13	178	4	int:SCGB1C1
GeneFamily	Phosphodiesterases	PDE1A PDE4A PDE4C PDE6G	1.66e-05	24	118	4	681
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD1 FZD7 FZD2	4.30e-05	11	118	3	286
GeneFamily	Ankyrin repeat domain containing	BCORL1 POTEC CASKIN2 ANKAR OSBPL1A TNKS2 ARAP2 ANKRD30BL	1.89e-04	242	118	8	403
GeneFamily	Ring finger proteins	VPS11 MARCHF10 RNF19A TTC3 RNF125 MID1 LONRF3 LONRF2	4.47e-04	275	118	8	58
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TTC28 TTC3 TTC29 CFAP70 CFAP46	9.43e-04	115	118	5	769
GeneFamily	Sterile alpha motif domain containing	KIF24 CASKIN2 TNKS2 ARAP2	2.64e-03	88	118	4	760
GeneFamily	Histone deacetylases, class I\|EMSY complex\|NuRD complex\|SIN3 histone deacetylase complex	SIN3B PHF12	2.67e-03	12	118	2	1243
GeneFamily	Myosin heavy chains	MYH7 MYH7B	4.20e-03	15	118	2	1098
GeneFamily	StAR related lipid transfer domain containing	STARD13 DLC1	4.20e-03	15	118	2	759
Coexpression	LAKE_ADULT_KIDNEY_C26_MESANGIAL_CELLS	STARD13 TTC28 KALRN SYNE1 EXT1 DST DLC1 PTPRG PLXDC2 PCDH9	3.71e-07	177	177	10	M39245
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRMPD4 EFCAB6 KALRN CPS1 CSMD3 FREM1 TENM4 PIK3C2G PLCH1 ADGRL3	3.85e-09	184	178	10	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRMPD4 EFCAB6 KALRN CPS1 CSMD3 FREM1 TENM4 PIK3C2G PLCH1 ADGRL3	3.85e-09	184	178	10	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRMPD4 EFCAB6 KALRN CPS1 CSMD3 FREM1 TENM4 PIK3C2G PLCH1 ADGRL3	3.85e-09	184	178	10	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYH7 KALRN MYH7B LRRTM3 CDH19 MFGE8 DLC1 PTPRG ADAMTS9 PCDH9	5.24e-09	190	178	10	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ADAMTS2 PEG10 DDR2 TNS2 LRRTM3 FZD1 TENM4 PTPRG SLC26A7 ADAMTS9	6.09e-09	193	178	10	cf2461af78f65616ce40d552ee9452295e3895ed
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ADAMTS2 PEG10 DDR2 TNS2 LRRTM3 FZD1 TENM4 PTPRG SLC26A7 ADAMTS9	6.09e-09	193	178	10	6ef9007c9d18fb775d08fb20cdf954a28d54d7eb
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ADAMTS2 PEG10 DDR2 TNS2 LRRTM3 FZD1 TENM4 PTPRG SLC26A7 ADAMTS9	6.09e-09	193	178	10	e4ea7ce011a80b81b841c907719aa532bed39d2e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A SPTBN2 FREM1 LRRC9 TFCP2L1 SH2D4A SLC26A7 PIK3C2G KCNIP4	2.28e-08	165	178	9	9bd332e5ede759a00a47728ea5558c215efdd77a
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	PDE1A TTC28 LRRTM3 FREM1 PTPRG PLXDC2 KCTD20 EEA1 PCDH9	5.85e-08	184	178	9	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 MARCHF10 SPTBN2 EML6 FREM1 CCDC88C TFCP2L1 SLC26A7 PIK3C2G	6.72e-08	187	178	9	2d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCell	COVID-19-kidney-CD-PC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE1A SPTBN2 EML6 FREM1 TFCP2L1 PIK3C2G MID1 KCNIP4 RASAL1	7.03e-08	188	178	9	8f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 SPTBN2 EML6 FREM1 PIK3C2G MID1 KCNIP4 PCDH9 RASAL1	8.05e-08	191	178	9	96b78b4e819ea6052334bfcbc7abbf35897df885
ToppCell	Fetal_29-31_weeks-Mesenchymal\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TTC28 ADAMTS2 KALRN DDR2 EXT1 FREM1 DST PTPRG PLXDC2	1.09e-07	198	178	9	21cf4d81386761d09d0f6829c01c198e5524176d
ToppCell	10x5'v1-week_14-16-Mesenchymal_adipo-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PDE1A ADAMTS2 DDR2 LRRTM3 FZD1 TENM4 DLC1 SLC26A7 ADAMTS9	1.14e-07	199	178	9	9b2262edbdec89166d895ab97527e0ee5f9b6010
ToppCell	10x5'v1-week_14-16-Mesenchymal_adipo\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PDE1A ADAMTS2 DDR2 LRRTM3 FZD1 TENM4 DLC1 SLC26A7 ADAMTS9	1.14e-07	199	178	9	251b3643dcd8f4645b17101bd716e66f12a20e88
ToppCell	10x5'v1-week_14-16-Mesenchymal_adipo-stroma-adipo-CAR\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PDE1A ADAMTS2 DDR2 LRRTM3 FZD1 TENM4 DLC1 SLC26A7 ADAMTS9	1.14e-07	199	178	9	117f4f43b6c06dda553799b1063e827bce697370
ToppCell	Neuronal-Excitatory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	UNC13B PDE1A KALRN PRICKLE1 PLXDC2 SLIT1 KCNIP4 PCDH9 ARAP2	1.19e-07	200	178	9	4409065bc7aa995354c71e0f9d6f3726cf393d6b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A SPTBN2 EML6 FREM1 LRRC9 SH2D4A SLC26A7 PIK3C2G	1.36e-07	146	178	8	e887e9de895fd453faa703997ef372cc6410fc49
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KCNH8 CFAP276 MARCHF10 LRRC9 TTC29 CFAP70 CFAP46 ANKRD30BL	3.47e-07	165	178	8	0c714e852f912b5749de4cb0895406673979b2e6
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KCNH8 CFAP276 MARCHF10 LRRC9 TTC29 CFAP70 CFAP46 ANKRD30BL	3.47e-07	165	178	8	82530f96aaefe28a13bad0474bbad043f127a86c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MARCHF10 SPTBN2 CDH19 FZD7 SLC26A7 PIK3C2G RASAL1 KLB	3.80e-07	167	178	8	166b7b4ca0663cde6d88219ee0bcc1988d03dab8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A SPTBN2 FREM1 LRRC9 TFCP2L1 SH2D4A SLC26A7 LONRF2	5.42e-07	175	178	8	98947a226b5a2ac7091ff9d34243ea7736add973
ToppCell	COVID-19-kidney-CD-IC-A\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE1A SPTBN2 FREM1 TFCP2L1 SH2D4A SLC26A7 KCNIP4 LONRF2	5.66e-07	176	178	8	45028197364c64e93e3ffe86aff773d47a477d49
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A PRICKLE1 SPTBN2 EML6 EXT1 FREM1 PIK3C2G KCNIP4	6.43e-07	179	178	8	d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	UNC13B SYNE1 TFCP2L1 DLC1 PTPRG PLCH1 PCDH9 LRRC36	6.71e-07	180	178	8	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DRC7 MARCHF10 EFCAB6 STOX1 KIF24 TTC29 CFAP70 CFAP46	7.00e-07	181	178	8	dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE1A CDH19 MFGE8 TENM4 DLC1 PTPRG ADAMTS9 ADGRL3	7.29e-07	182	178	8	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	COVID-19-kidney-CD-IC-A\|kidney / Disease (COVID-19 only), tissue and cell type	PDE1A SPTBN2 FREM1 FZD7 TFCP2L1 SH2D4A SLC26A7 LONRF2	7.60e-07	183	178	8	5c7597a5b2bf6a481ca2c7e68560179214150fa0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN2 FREM1 TFCP2L1 SH2D4A SLC26A7 PIK3C2G MID1 KCNIP4	8.25e-07	185	178	8	3d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE1A KALRN PRICKLE1 SLIT1 VPS13A KCNIP4 RASAL1 ARAP2	8.59e-07	186	178	8	84ba666237c18189d7e7556bd92dd953af733c00
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	UNC13B PDE1A KCNH8 LLGL2 KCNIP4 PLCH1 ARAP2 ANKRD30BL	9.69e-07	189	178	8	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	UNC13B PDE1A KALRN PRICKLE1 SLIT1 VPS13A KCNIP4 ARAP2	9.69e-07	189	178	8	a75226616340045b581d08429d2e123e041dee55
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN2 FREM1 TFCP2L1 SLC26A7 PIK3C2G MID1 KCNIP4 RASAL1	1.09e-06	192	178	8	f7e7491426bbd6ed29a465b58bf67acb93dbb90a
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	UNC13B PDE1A KCNH8 LLGL2 KCNIP4 PLCH1 RASAL1 ANKRD30BL	1.09e-06	192	178	8	b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCell	COVID-19-kidney-CD-PC\|kidney / Disease (COVID-19 only), tissue and cell type	PDE1A SPTBN2 EML6 FREM1 PIK3C2G MID1 KCNIP4 RASAL1	1.13e-06	193	178	8	738689d009e4b118d7ce3171a207294b95cbe78b
ToppCell	Thalamus-Neuronal\|Thalamus / BrainAtlas - Mouse McCarroll V32	CLSTN3 FRMPD4 SPTBN2 TTC3 PTPRN KRT222 CAMTA1 LONRF2	1.13e-06	193	178	8	712a4acd1167e43543950bc819ff11984e6f718d
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TTC28 ADAMTS2 KALRN CSMD3 FREM1 DST PTPRG PLXDC2	1.18e-06	194	178	8	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	UNC13B KCNH8 NUP62CL LLGL2 PIK3C2G PLCH1 LONRF2 LRRC36	1.18e-06	194	178	8	c011cd59bb4ca4134331cba0f5d73bdbd7011d64
ToppCell	Substantia_nigra-Macroglia-CSF_related\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DRC7 CFAP276 EFCAB6 NUP62CL TTC29 CFAP70 LRRC36	1.28e-06	136	178	7	47663c5d81c766a333207a44fc5b58b07309ee76
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DRC7 CFAP276 EFCAB6 NUP62CL TTC29 CFAP70 LRRC36	1.28e-06	136	178	7	6d2e5b871f4cf8d64e6fe0be666fb3490797c635
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DRC7 CFAP276 EFCAB6 NUP62CL TTC29 CFAP70 LRRC36	1.28e-06	136	178	7	fd4269d194c7c11c6ab4383393a01efab05cbace
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DRC7 CFAP276 EFCAB6 NUP62CL TTC29 CFAP70 LRRC36	1.28e-06	136	178	7	3f6cec8d52c84191f7f6e2dd4dc47524dfd5b21b
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DRC7 CFAP276 EFCAB6 NUP62CL TTC29 CFAP70 LRRC36	1.28e-06	136	178	7	67d736096d6b6ddb4722809557f5e987063b8d23
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	PDE1A TTC28 KALRN PRICKLE1 DDR2 TENM4 DST PTPRG	1.32e-06	197	178	8	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 KALRN SYNE1 DDR2 EML6 EXT1 DLC1 PCDH9	1.32e-06	197	178	8	85a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 KALRN SYNE1 DDR2 EML6 EXT1 DLC1 PCDH9	1.32e-06	197	178	8	e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	DDR2 TNS2 FZD1 ZNF462 TENM4 DLC1 SLC26A7 ADAMTS9	1.32e-06	197	178	8	5afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	DDR2 TNS2 FZD1 ZNF462 TENM4 DLC1 SLC26A7 ADAMTS9	1.32e-06	197	178	8	1baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	DDR2 TNS2 FZD1 ZNF462 TENM4 DLC1 SLC26A7 ADAMTS9	1.32e-06	197	178	8	b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DRC7 CFAP276 EFCAB6 STOX1 KIF24 PLCH1 LONRF2 CFAP46	1.32e-06	197	178	8	6e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DRC7 MARCHF10 EFCAB6 EML6 LRRC9 OTOF PIK3C2G CFAP70	1.48e-06	200	178	8	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SYNE1 DDR2 FREM1 MFGE8 DLC1 PTPRG PLXDC2 PCDH9	1.48e-06	200	178	8	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MARCHF10 SPTBN2 CCDC88C TFCP2L1 SH2D4A SLC26A7 PIK3C2G	3.48e-06	158	178	7	debebc8534a80e5500051f6fd352dc201585968d
ToppCell	Control-APC-like-Monocyte-derived_macrophages\|Control / group, cell type (main and fine annotations)	PALD1 FLT3 TMEM185B NUP62CL SEC16A RMND1 NEURL4	3.78e-06	160	178	7	463dd624ca5c375b6ff7c269f4ef4b9d74f4b669
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-stromal_related\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NPR3 PDE4C FRMPD4 TBC1D25 OSBPL1A ZNF432 KCNIP4	3.94e-06	161	178	7	8aaca49b53a551395f4025ac4e535c7b0ce41a49
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NPR3 PDE4C FRMPD4 TBC1D25 OSBPL1A ZNF432 KCNIP4	3.94e-06	161	178	7	deb10628d258fb813c293f81fb71be8e383dc82a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN2 LRRC9 TFCP2L1 SH2D4A SLC26A7 KCNIP4 LONRF2	4.45e-06	164	178	7	d847d509bb1791638032ade6755d8164586b5bd5
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A SPTBN2 LRRC9 TFCP2L1 SH2D4A SLC26A7 LONRF2	4.82e-06	166	178	7	6fe8db8d45177a78605681f22e04fa8d0594f2df
ToppCell	COVID-19-Heart-Neuronal\|COVID-19 / Disease (COVID-19 only), tissue and cell type	STARD13 KCNH8 CDH19 DST DLC1 PCDH9 ADGRL3	5.21e-06	168	178	7	88c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MARCHF10 LRRC9 TFCP2L1 SH2D4A SLC26A7 PIK3C2G LONRF2	5.42e-06	169	178	7	2a21f2cef959526bfe3c8f081f4f7e9dd4e01a37
ToppCell	severe_influenza-pDC\|World / disease group, cell group and cell class (v2)	PALD1 FLT3 IRF4 MALRD1 ITM2C KIF17 LRRC36	5.63e-06	170	178	7	b9c08af83241666bbdbed9109cadcd088c0f647d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MARCHF10 SPTBN2 LRRC9 TFCP2L1 SH2D4A SLC26A7 PIK3C2G	6.32e-06	173	178	7	0bc2aacae60c6d3276b0949eb0748b4ac1f56e54
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	DRC7 CFAP276 TTC29 CFAP70 PLCH1 LRRC36 CFAP46	6.56e-06	174	178	7	f41d05a3703d7092bd3c4a97c15ae13069aaa4ad
ToppCell	AT1-AT2_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	UNC13B MYH7B PEG10 LLGL2 ADAMTS9 NT5DC2 MID1	6.81e-06	175	178	7	bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	DRC7 CFAP276 TTC29 CFAP70 PLCH1 LRRC36 CFAP46	6.81e-06	175	178	7	c01a15b2084da4a18f8ff3623f44eb9dfe499f10
ToppCell	facs-Skin-Anagen-24m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRC7 EFCAB6 FZD7 ZNF76 ITM2C FZD2 CFAP46	6.81e-06	175	178	7	5552ff1e13f931c8cd7780726c90b5609497a648
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN2 FREM1 SH2D4A SLC26A7 PIK3C2G KCNIP4 LONRF2	7.07e-06	176	178	7	cb21342dd135cc80a50aafe7bf8bf31265db68dd
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRC7 CFAP276 EFCAB6 TTC29 CFAP70 PLCH1 CFAP46	7.61e-06	178	178	7	58857bb8c13e0e1c6d9f5c1258f00fff62063d68
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRC7 CFAP276 EFCAB6 TTC29 CFAP70 PLCH1 CFAP46	7.61e-06	178	178	7	8b7df6ab8709d9ab9dff97677cc4561aec2745bc
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRC7 CFAP276 EFCAB6 TTC29 CFAP70 PLCH1 CFAP46	7.61e-06	178	178	7	b0baf5667e3301898b3e45e974b8a8530af6a338
ToppCell	droplet-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte-type_1_alveolar_epithelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TDRD5 MYH7 PEG10 PGBD1 TFCP2L1 PIK3C2G SPRTN	7.89e-06	179	178	7	ca70a5518c5a5392e088c103e0cb44aa084f5332
ToppCell	droplet-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TDRD5 MYH7 PEG10 PGBD1 TFCP2L1 PIK3C2G SPRTN	7.89e-06	179	178	7	c451b074b04eb5d6c575c6abaedda579c6744bbf
ToppCell	COVID-19-kidney-REN+Pericyte\|kidney / Disease (COVID-19 only), tissue and cell type	STARD13 PDE1A KALRN MFGE8 DLC1 NT5DC2 HECW2	7.89e-06	179	178	7	342c1cc4444f51b8dcb30d3adc98285a25669c6e
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	SPG7 RNF19A SMCHD1 VPS13A N4BP2L2 ARAP2 ZC3HAV1	8.49e-06	181	178	7	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRC7 CFAP276 NUP62CL TTC29 CFAP70 LRRC36 CFAP46	8.80e-06	182	178	7	587636c0f127231de21acd8aa632b74ff22ca8c2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRC7 CFAP276 NUP62CL TTC29 CFAP70 LRRC36 CFAP46	8.80e-06	182	178	7	adfadd7893e74b3002f13f00875e3667d3493e0c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 SPTBN2 EML6 FREM1 CCDC88C TFCP2L1 PIK3C2G	9.12e-06	183	178	7	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 SPTBN2 EML6 FREM1 PIK3C2G MID1 KCNIP4	9.12e-06	183	178	7	d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCell	myeloid-Dendritic_cell-Plasmacytoid_dendritic_cell\|World / Lineage, cell class and subclass	PALD1 FLT3 IRF4 DQX1 ITM2C KIF17 LRRC36	9.45e-06	184	178	7	11619778bc773ecd1a9867330be04deaf324f31e
ToppCell	COPD-Stromal-Pericyte\|COPD / Disease state, Lineage and Cell class	TNS2 CDH19 MFGE8 DLC1 PTPRG ADAMTS9 ITM2C	9.45e-06	184	178	7	a56264a22dfc2d3672b20134ab7c3c7c23da5ae1
ToppCell	droplet-Lung-nan-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD13 H6PD FZD1 HOXA5 MFGE8 PLXDC2 PIK3C2G	9.45e-06	184	178	7	89ac32e374a4379e4a6c6ea7603b1378b77c147f
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD13 H6PD FZD1 HOXA5 MFGE8 PLXDC2 PIK3C2G	9.45e-06	184	178	7	4df6027fa635996c1eddb920f88a5265772df1cd
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 SPTBN2 EML6 CCDC88C TFCP2L1 PIK3C2G RASAL1	9.78e-06	185	178	7	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	UNC13B KCNH8 LLGL2 PIK3C2G PLCH1 LRRC36 ANKRD30BL	1.01e-05	186	178	7	bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KALRN DDR2 TNS2 CDH19 PTPRG ADAMTS9 NT5DC2	1.05e-05	187	178	7	86250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCell	COPD-Epithelial-Ciliated\|COPD / Disease state, Lineage and Cell class	DRC7 CFAP276 MARCHF10 TTC29 CFAP70 PLCH1 CFAP46	1.05e-05	187	178	7	f0fd0792f6926f705d175f6e6fd480f12c7a3bd4
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	UNC13B KCNH8 LLGL2 PIK3C2G PLCH1 LRRC36 ANKRD30BL	1.05e-05	187	178	7	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	COPD-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	STARD13 PDE4C TFCP2L1 DLC1 PTPRG LONRF3 PCDH9	1.05e-05	187	178	7	030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCell	Control-Endothelial_cells-Endothelial_cells_(general)\|Control / group, cell type (main and fine annotations)	STARD13 PALD1 NPR3 TTC28 PTPRG CASKIN2 HECW2	1.05e-05	187	178	7	fb5bcbc8effdbf0e57fcb71aca990a4aa0d65ce8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 SPTBN2 EML6 FREM1 PIK3C2G MID1 KCNIP4	1.05e-05	187	178	7	f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE1A DDR2 CDH19 FREM1 TENM4 PCDH9 ADGRL3	1.09e-05	188	178	7	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	Adult-Epithelial-ciliated_cell-D231\|Adult / Lineage, Cell type, age group and donor	DRC7 CFAP276 MARCHF10 EFCAB6 TTC29 CFAP70 CFAP46	1.09e-05	188	178	7	34b11f72ca73153d02edcd09b38983ad1a504659
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	UNC13B PDE1A KCNH8 LLGL2 PLCH1 LONRF2 ANKRD30BL	1.09e-05	188	178	7	0d86044bc340e3efb90d0022dd299873639d831c
ToppCell	Control-Endothelial_cells\|Control / group, cell type (main and fine annotations)	STARD13 PALD1 TTC28 KALRN PTPRG CASKIN2 HECW2	1.09e-05	188	178	7	3953b08abfea93468fc8d177bdb16ca7c6ffa1ab
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	UNC13B PDE1A KCNH8 LLGL2 VPS13A PLCH1 ANKRD30BL	1.09e-05	188	178	7	beb2df2332a46cc81b10e8e29fc9829020111f03
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	UNC13B KCNH8 NUP62CL LLGL2 PIK3C2G PLCH1 LRRC36	1.12e-05	189	178	7	5d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DRC7 CFAP276 MARCHF10 EFCAB6 TTC29 CFAP70 CFAP46	1.12e-05	189	178	7	68a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	STARD13 PALD1 KALRN SYNE1 CASKIN2 HECW2 ADGRL3	1.12e-05	189	178	7	b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN2 EML6 CCDC88C PIK3C2G MID1 RASAL1 ZC3HAV1	1.12e-05	189	178	7	fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN2 FREM1 CCDC88C TFCP2L1 SLC26A7 PIK3C2G RASAL1	1.12e-05	189	178	7	532aaf02b364c5c4f58a2021c7c21d86df3875c9
Disease	2-stearoylglycerophosphocholine measurement	EML6 MALRD1	3.42e-05	2	173	2	EFO_0021098
Disease	Inherited neuropathies	SPG7 SPTBN2 SPART PNPLA6	8.85e-05	40	173	4	C0598589
Disease	gonadal dysgenesis (implicated_via_orthology)	STARD13 DLC1	2.03e-04	4	173	2	DOID:14447 (implicated_via_orthology)
Disease	pulmonary arterial hypertension	PDE1A LONP1 DNAJC10	2.81e-04	22	173	3	EFO_0001361
Disease	response to bronchodilator, response to corticosteroid	CSMD3 ZNF432	3.38e-04	5	173	2	GO_0031960, GO_0097366
Disease	Lateral Sclerosis	SPG7 PNPLA6	3.38e-04	5	173	2	C0154682
Disease	free androgen index	RNMT SMCHD1 BCORL1 CPS1 AKR1C2 PTPRG KCNIP4 ITM2C TNKS2	3.84e-04	374	173	9	EFO_0007005
Disease	solute carrier family 22 member 16 measurement	MALRD1 PLXDC2	5.05e-04	6	173	2	EFO_0802079
Disease	lumbar disc degeneration	MYH7B STOX1 SLC26A7	5.83e-04	28	173	3	EFO_0004994
Disease	respiratory failure, COVID-19	FREM1 DST DPP9	6.47e-04	29	173	3	EFO_0009686, MONDO_0100096
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	MYH7 SYNE1	7.04e-04	7	173	2	C0751337
Disease	cerebellar ataxia (implicated_via_orthology)	PNPLA6 VPS13A	9.35e-04	8	173	2	DOID:0050753 (implicated_via_orthology)
Disease	diastolic blood pressure, self reported educational attainment	PIK3C2G SLIT1	9.35e-04	8	173	2	EFO_0004784, EFO_0006336
Disease	Colorectal Carcinoma	UNC13B CLSTN3 KALRN SYNE1 SPTBN2 ZNF442 CSMD3 DLC1 INTS13 VPS13A ZNF432 LONRF2	9.38e-04	702	173	12	C0009402
Disease	Global developmental delay	FRMPD4 SPTBN2 SPART DEGS1 ZNF462	1.15e-03	133	173	5	C0557874
Disease	Developmental delay (disorder)	SPTBN2 SPART DEGS1	1.33e-03	37	173	3	C0424605
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH7 MYH7B	1.49e-03	10	173	2	DOID:0111269 (implicated_via_orthology)
Disease	postburn hypertrophic scarring severity measurement	KCNIP4 ARAP2	1.49e-03	10	173	2	EFO_0007747
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH7 MYH7B	1.49e-03	10	173	2	DOID:0111602 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH7 MYH7B	1.49e-03	10	173	2	DOID:0111596 (implicated_via_orthology)
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH7 MYH7B	1.49e-03	10	173	2	DOID:0110454 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH7 MYH7B	1.49e-03	10	173	2	DOID:0080719 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH7 MYH7B	1.49e-03	10	173	2	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH7 MYH7B	1.49e-03	10	173	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH7 MYH7B	1.49e-03	10	173	2	DOID:0080326 (implicated_via_orthology)
Disease	Sodium measurement	MFRP UGT1A1	1.82e-03	11	173	2	C0337443
Disease	Adverse Event by CTCAE Category	MFRP UGT1A1	1.82e-03	11	173	2	C1879645
Disease	interleukin-22 receptor subunit alpha-2 measurement	FLT3 SEC22B	1.82e-03	11	173	2	EFO_0020500
Disease	age at first sexual intercourse measurement	KCNH8 RNMT BCORL1 IRF4 VIRMA FZD7 TENM4 CAMTA1	1.98e-03	383	173	8	EFO_0009749
Disease	stromal cell-derived factor 1 alpha measurement	SPG7 CPS1 KCNIP4	2.06e-03	43	173	3	EFO_0008293
Disease	hair colour measurement, hair morphology measurement	SPG7 IRF4	2.17e-03	12	173	2	EFO_0007821, EFO_0007822
Disease	distal myopathy (implicated_via_orthology)	MYH7 MYH7B	2.17e-03	12	173	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH7 MYH7B	2.17e-03	12	173	2	DOID:2106 (implicated_via_orthology)
Disease	microphthalmia (implicated_via_orthology)	MFRP MID1	2.17e-03	12	173	2	DOID:10629 (implicated_via_orthology)
Disease	response to beta blocker	EML6 PNPLA6 LONRF2	2.35e-03	45	173	3	EFO_0007766
Disease	potassium measurement	EML6 TFCP2L1 PCDH9	2.35e-03	45	173	3	EFO_0009283
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH7 MYH7B	2.55e-03	13	173	2	DOID:397 (implicated_via_orthology)
Disease	glutaroyl carnitine measurement	GCDH CPS1	2.55e-03	13	173	2	EFO_0021005
Disease	triacylglycerol 46:2 measurement	PMPCB GTF3C2	2.97e-03	14	173	2	EFO_0010402
Disease	Left ventricular noncompaction	MYH7 MYH7B	2.97e-03	14	173	2	C1960469
Disease	Tourette syndrome	FLT3 CSMD3 TENM4	3.17e-03	50	173	3	EFO_0004895
Disease	distal arthrogryposis (implicated_via_orthology)	MYH7 MYH7B	3.41e-03	15	173	2	DOID:0050646 (implicated_via_orthology)
Disease	preeclampsia, hypertension, pregnancy-induced	NPR3 TNS2	3.89e-03	16	173	2	EFO_0000668, MONDO_0024664
Disease	plasma beta-amyloid 1-40 measurement	STARD13 TTC29	4.39e-03	17	173	2	EFO_0005659
Disease	partial epilepsy	FZD7 ADGRL3	4.39e-03	17	173	2	EFO_0004263
Disease	muscular dystrophy (is_implicated_in)	SGCB SYNE1	4.39e-03	17	173	2	DOID:9884 (is_implicated_in)
Disease	glutarylcarnitine (C5-DC) measurement	GCDH CPS1	4.39e-03	17	173	2	EFO_0800030
Disease	heel bone mineral density, urate measurement	RNMT EML6 SH2D4A INTS13 PLCH1	4.47e-03	182	173	5	EFO_0004531, EFO_0009270
Disease	Malignant neoplasm of breast	KALRN SYNE1 BCORL1 H6PD TTC3 MFGE8 LLGL2 OTOF RRP9 ZNF644 ZNF432 LONRF3 RMND1 ZNF646	4.49e-03	1074	173	14	C0006142
Disease	body surface area	NPR3 PDE4C SMCHD1 H6PD CPS1 ZNF462 NCOR2 DLC1 PTPRG SLIT1	4.82e-03	643	173	10	EFO_0022196
Disease	microglial activation measurement	CCDC88C TTC29 KIF17	5.06e-03	59	173	3	EFO_0010940
Disease	cytomegalovirus virus reactivation, response to allogeneic hematopoietic stem cell transplant	PDE1A DNAJC10	5.47e-03	19	173	2	EFO_0007044, EFO_0020106

Protein segments in the cluster

Peptide	Gene	Start	Entry
HIGELYSNNQHGFSE	PTPRG	836	P23470
ADFQLHTHVNDGTEF	VDAC3	176	Q9Y277
SNEDVYFHHVLRTEG	TDRD5	641	Q8NAT2
GYGSHSEVQHNDVSE	CAMTA1	296	Q9Y6Y1
VQNEDGFSHYSLTVH	CLSTN3	401	Q9BQT9
DDVETFNHALQHVAY	CLSTN3	581	Q9BQT9
DHHDYLLITENGSFT	CSMD3	1116	Q7Z407
VSDYHEHGSLFDYLN	ACVR1B	281	P36896
RHAYSFHQSSEEAGD	BTBD17	426	A6NE02
FHQSSEEAGDFLAHA	BTBD17	431	A6NE02
EDVNHRDNAGYTALH	BCORL1	1521	Q5H9F3
GVYQSEHLFESDHQS	ADGRL3	141	Q9HAR2
AALYGLLFHSHADQD	CFAP46	1111	Q8IYW2
EQYLLHFHESGFTTV	ARAP2	21	Q8WZ64
NIVNEIYHDESLGAH	ADAMTS2	296	O95450
HEVFQEEGLHTSIYS	NPR3	221	P17342
DLDFRLAALYNHHTG	CFAP276	71	Q5T5A4
HQLAFYVLDEDTVGH	RASAL1	66	O95294
EDLPNQFYRDSHTLH	RAD17	226	O75943
ENENHNYHIGFESSI	PIK3C2G	161	O75747
QHANTSANYDVELLH	INTS13	271	Q9NVM9
LSSLDIDHNQYKFGH	MYH7	746	P12883
EIHDFAQLSENTYHV	PALD1	211	Q9ULE6
EYLDASHNHVITLEG	LRRC9	741	Q6ZRR7
INVSDEAGYTIFHHA	ANKAR	526	Q7Z5J8
LNDYLDAIEHNGHSR	HECW2	416	Q9P2P5
GHSIELQFHNFSLEA	MFRP	336	Q9BY79
YENEKNNGTAHFLEH	PMPCB	91	O75439
DVGLLEYQHHSRDYA	NCOR2	36	Q9Y618
LHNYLGLTNELFSHE	PNPLA6	331	Q8IY17
HGDTTFEYQDLCRQH	PTPRN	621	Q16849
DLASELVHYGFLHED	NRBP2	466	Q9NSY0
GIHFSQQDDHKLYSQ	LYSMD3	281	Q7Z3D4
AEDYGEHHLAVLTNL	LLGL2	856	Q6P1M3
AYSLNGHEFDFIHDV	MFGE8	161	Q08431
ISHGHTYDASNLDQV	IRF4	276	Q15306
VSGLDDFTQTHEYHV	DDR2	236	Q16832
LSNDGAHKQFDHYLE	KCTD20	226	Q7Z5Y7
YVTGQEFHSDTDHLD	DST	2561	Q03001
VKHQVYEEAGSDFHQ	KIAA1109	3221	Q2LD37
TAAYEALLQDHEHLG	CCDC88C	1161	Q9P219
DAITNEEYGEFHQSL	HSP90AA5P	126	Q58FG0
GSLDLDHTQYQFGHT	MYH7B	796	A7E2Y1
ERGLENSLHASEQHY	KRT222	76	Q8N1A0
SGQQSHTYDDLLHKN	LRRC36	636	Q1X8D7
SSTGFHIQENEESHY	PCDH9	1031	Q9HC56
DDYRDFVNLDHAHSL	PDCD2L	196	Q9BRP1
AAIHDYEHTGTTNNF	PDE1A	256	P54750
YNDESVLENHHLAVG	PDE4A	496	P27815
YNDASVLENHHLAVG	PDE4C	451	Q08493
LHNYGDHSSVSEQFR	HOXA5	21	P20719
SDSDFHGDLTFQHVF	NFE2L3	481	Q9Y4A8
SELNIEDYFSHHLAV	FBXO39	196	Q8N4B4
LQAGVVRYHHDDSDS	FREM1	476	Q5H8C1
GHEAIEANSQYFHLA	FZD2	361	Q14332
HFLFNAFDTDHNGAV	KCNIP4	126	Q6PIL6
SQLTEEFDGSLDYNH	KALRN	166	O60229
ALIDQYHEGLSDHIQ	PEG10	201	Q86TG7
ELSFGNAHHRAEYSQ	KIF24	721	Q5T7B8
SLDEIYHTGTFAQIH	LONP1	181	P36776
RNGADHLLADAYSGH	NSMF	41	Q6X4W1
ATDYLTDHEIAHNLF	GDPGP1	276	Q6ZNW5
YEELAALHDSVHQQS	LONRF2	646	Q1L5Z9
QEAGADAFLIQYDAH	MROH1	516	Q8NDA8
SAFHAEGLNNDFIFH	OSBPL1A	656	Q9BXW6
AAFNSNGHLTVENYH	PHOSPHO2	126	Q8TCD6
NVNYQDADGFSALHH	CASKIN2	41	Q8WXE0
HTDGDHSSLIQVYEA	DQX1	521	Q8TE96
HDFQRGLTAYHDISL	ITM2C	146	Q9NQX7
ELDHGASGYNHDETQ	PRICKLE1	501	Q96MT3
YDHNGDVSAHFLSLV	MALRD1	106	Q5VYJ5
ADHTANINHGSFIYL	MALRD1	511	Q5VYJ5
HGNSFHSEDEIEYEN	FLT3	756	P36888
GHEAIEANSQYFHLA	FZD1	436	Q9UP38
HEAIEANSQYFHLAA	FZD7	371	O75084
LFKHYEAVHDAGNDS	EEA1	56	Q15075
AFDQVDDHLQTPYHE	GSKIP	91	Q9P0R6
TYNGQEHDVNFDDHG	CPS1	961	P31327
LVHGDSENFSEVYGH	ADAMTS9	1781	Q9P2N4
GSDTRNALYHVHNGE	EXT1	276	Q16394
NLEAVNTYEGTHDIH	GCDH	406	Q92947
SHYHAITQEFENFDT	EFCAB6	1176	Q5THR3
INDHHSEADEEFYLS	CENPC	141	Q03188
ESGEHYEVTLLHFLQ	DPP9	846	Q86TI2
DEEAQLSFHGVAYVN	CFAP70	331	Q5T0N1
EHRHLYIDNAYSSDG	FRMPD4	591	Q14CM0
DAIETQAYQLAGHSF	POLQ	2111	O75417
ENGFHGLLAHDSEYA	FAM120C	251	Q9NX05
LLTFNVGYHNEHHDF	DEGS1	251	O15121
YAQYEHFHLGSENQL	ANGPT4	391	Q9Y264
HSYSTQDEHFLGIES	DRC7	326	Q8IY82
ENHNYFPVNSAHEFA	MARCHF10	526	Q8NA82
LEEGHSSTVAAHYNE	RNMT	141	O43148
VHSDYLTFEDQFIQH	MC3R	101	P41968
NDTYGAAHNLLVAHA	KLB	706	Q86Z14
HYLNDGDDIIYHTAS	EML5	1381	Q05BV3
HYLNDGADIIFHTAA	EML6	1381	Q6ZMW3
QSNIHEYEGHHSAEQ	DNAJC10	531	Q8IXB1
GSHDHIQQYSDIEDF	DUS2	216	Q9NX74
FGHDHFSAQQLATEL	H6PD	176	O95479
NSEATFAELHIVHYD	CA14	126	Q9ULX7
AYLEDLHSEFDEQHG	SEC22B	86	O75396
FQHLDHTGKRVDAYD	SEC24C	461	P53992
LSGREHNFNTYSDDI	MEP1B	181	Q16820
EEHHFYFNLSVEDTN	CDH19	501	Q9H159
HNGTTILDEYGHNLD	NEURL4	616	Q96JN8
EAFNHLELHELAQYG	PDE6G	71	P18545
TDVHYHSLTGEGNFN	OTOF	1776	Q9HC10
DEYGNTTLHYAVHNE	POTEC	236	B2RU33
QFTFDGAYHVDHVTE	KIF17	51	Q9P2E2
ESGATFHTYLNHLIQ	STARD13	901	Q9Y3M8
DNAHYTESDQTDHLA	TEX55	336	Q96M34
DLHLSITDDYDNHTG	SMCHD1	1516	A6NHR9
FPHHDNELAQSEAYF	CARS1	371	P49589
DAEFHTYLNHEGQLS	TBC1D25	201	Q3MII6
DQYSVLEGDAHTHET	SYNE1	3516	Q8NF91
EYGNISYDLHHEDNE	TMEM185A	291	Q8NFB2
EYGNISYDLHHEDSE	TMEM185B	291	Q9H7F4
YLDHNHISNIDENAF	LRRTM3	91	Q86VH5
EAEHQNLTAYQHGSD	PRDM15	491	P57071
DSNVINHFYHDDVPL	OR5AL1	186	P0C617
RFLLVYLHGDDHQDS	FAF2	171	Q96CS3
DENTKHYELLNYSEH	PHF12	846	Q96QT6
HVHLQDNYNLGSFTF	PLXDC2	231	Q6UX71
VYDEHQEQHSEGRSA	SIN3B	631	O75182
FATADEYHLGNLSQD	RMND1	176	Q9NWS8
EYHLGNLSQDLASHG	RMND1	181	Q9NWS8
GSFSIQHTYHVDIND	SEMG2	61	Q02383
NHNSDGYEHQDPAFF	SI	661	P14410
IFSNLHFADNGHLDQ	PGBD1	501	Q96JS3
QNILFSTDYETHEFH	SGCB	176	Q16585
GHTSVHTLNFEYAVE	SPG7	536	Q9UQ90
FKQNENGEYTEHLHS	TFCP2L1	196	Q9NZI6
GHLGNDDSADYQHFL	DLC1	1311	Q96QB1
YTNNDSYVIHHGDLR	ANKRD30BL	26	A7E2S9
FHHIDSAHVYNNEEQ	AKR1C2	46	P52895
AYQHSGHLESKDINQ	C10orf62	151	Q5T681
YNAGEATHHAVDSAV	SPART	581	Q8N0X7
AGYEQQDAHEFLIAA	USP22	256	Q9UPT9
EEDSGHLHSQLEVSY	nan	166	Q6ZTK2
DHLYSKGNHDGAVQQ	VPS11	396	Q9H270
DYHDGAATFLLINHT	VPS13A	2406	Q96RL7
HLQVSHTLFYDDFID	RNF125	191	Q96EQ8
HSLNDQAKGESHEYV	RLF	641	Q13129
VFSDLGQLYHHEAQH	RLF	781	Q13129
YFGDALKETNNNHSH	RNF19A	811	Q9NV58
ANHSSHQEDTYGALD	SEC16A	981	O15027
VAASHELGQDYEHVT	SPTBN2	1716	O15020
FKENENGEYTEHLHS	TFCP2	216	Q12800
AENSYVETLFGHQDA	RRP9	271	O43818
VQYEHSHLEGTENHS	STOX1	916	Q6ZVD7
AEQYNAGHLSTAFHL	TBC1D23	346	Q9NUY8
DNGSIAFYDALNSIH	MID1	611	O15344
LSQEFEAYINASGEH	UGT1A1	286	P22309
TYDDLGSLERHHQSQ	ZNF646	966	O15015
AAAYFEGHHLNAENV	TTC3	1381	P53804
AHYLENLHFTIDGVD	TENM4	2601	Q6N022
NLHFTIDGVDTHYFV	TENM4	2606	Q6N022
DAYSFLGVDQLQHAT	SH2D4A	401	Q9H788
LHENLFHYLTDIQGS	UNC13B	746	O14795
FLHENEYVHGNVTAE	VRK3	296	Q8IV63
DYFLGHSLEFDQAHL	NT5DC2	201	Q9H857
LHNAASYGHVDVAAL	TNKS2	716	Q9H2K2
LHYSNGTTEHQVESF	PLCH1	476	Q4KWH8
GANITVYHTFHDEVD	SPRTN	146	Q9H040
HKIHAAGTFYENDEN	ZNF234	671	Q14588
YEDTGSNNFLHEIHD	ZNF644	921	Q9H582
DFYSFQNHETTHTGE	ZNF442	471	Q9H7R0
HEHYLGENTVENSSD	TTC28	1261	Q96AY4
GQLLEAAEHYEAFHQ	TTC29	196	Q8NA56
VEQYHEHNAFGNTAS	ZNF432	101	O94892
TNFEDLQQHYGEHHP	ZNF462	896	Q96JM2
VNHHYLLFQDTDLGS	GTF3C2	791	Q8WUA4
HSSSLRQHQGDYDGQ	ZNF304	206	Q9HCX3
NFDSFLHETHENKYG	ZC3HAV1	801	Q7Z2W4
AGANQYTFHLEATEN	RPE	86	Q96AT9
YSIDDNQEFLAHGLS	SLC26A7	336	Q8TE54
NGDNDHIAVELYQGH	SLIT1	1206	O75093
FIVLGQEEYGEHHSS	WDR91	396	A4D1P6
ETDHSDLLGTLHNLY	VIRMA	786	Q69YN4
YENFNQHHEDSVDGS	TNS2	456	Q63HR2
EAVQLEDGSTAYIHH	ZNF76	86	P36508
SDSVLNHHQLGYADR	ZNF554	256	Q86TJ5
QHDLTYNLREGHESD	KCNH8	666	Q96L42
IYFTLESHENALHDA	LONRF3	286	Q496Y0
NRDGIVFSTDDYFHH	N4BP2L2	426	Q92802
QSGLHYLQDADEEHV	NUP62CL	161	Q9H1M0