Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	siRNA-mediated heterochromatin formation	TDRD5 MAEL TDRD12	1.09e-05	11	85	3	GO:0141194
GeneOntologyBiologicalProcess	transposable element silencing by siRNA-mediated heterochromatin formation	TDRD5 MAEL TDRD12	1.09e-05	11	85	3	GO:0141007
GeneOntologyBiologicalProcess	transposable element silencing by heterochromatin formation	TDRD5 MAEL TDRD12	5.27e-05	18	85	3	GO:0141005
GeneOntologyBiologicalProcess	NLS-bearing protein import into nucleus	IPO5 RGPD2 KPNB1	7.32e-05	20	85	3	GO:0006607
GeneOntologyBiologicalProcess	piRNA processing	TDRD5 MAEL TDRD12	9.83e-05	22	85	3	GO:0034587
GeneOntologyBiologicalProcess	ribosomal protein import into nucleus	IPO5 KPNB1	1.00e-04	4	85	2	GO:0006610
GeneOntologyBiologicalProcess	regulatory ncRNA-mediated heterochromatin formation	TDRD5 MAEL TDRD12	1.13e-04	23	85	3	GO:0031048
GeneOntologyBiologicalProcess	negative regulation of Ras protein signal transduction	RASA2 RASA4 RASA4B	2.05e-04	28	85	3	GO:0046580
GeneOntologyBiologicalProcess	protein-DNA complex organization	KNTC1 TDRD5 RUVBL1 RBM15B NSD1 MAEL CHD3 CHD7 LMNB2 GNAS ZZEF1 NSD3 TDRD12	2.16e-04	999	85	13	GO:0071824
GeneOntologyBiologicalProcess	chromatin remodeling	TDRD5 RUVBL1 RBM15B NSD1 MAEL CHD3 CHD7 LMNB2 GNAS NSD3 TDRD12	2.27e-04	741	85	11	GO:0006338
GeneOntologyBiologicalProcess	RNA localization	RGPD2 RUVBL1 RBM15B CCT7 BICD1 KPNB1	2.77e-04	217	85	6	GO:0006403
GeneOntologyBiologicalProcess	chromatin organization	TDRD5 RUVBL1 RBM15B NSD1 MAEL CHD3 CHD7 LMNB2 GNAS ZZEF1 NSD3 TDRD12	2.98e-04	896	85	12	GO:0006325
GeneOntologyCellularComponent	multi-eIF complex	EIF1AX EIF1AY	9.98e-05	4	86	2	GO:0043614
MousePheno	abnormal blastocyst formation	RGPD2 POLR1A RUVBL1 EIF5B	2.41e-05	39	61	4	MP:0012128
Domain	-	PHLDB3 RGPD2 PHLDB1 GRK3 RASA2 KALRN RASA4 MCF2L2 RASA4B PLEKHA5 PPP4R3A	1.39e-06	391	84	11	2.30.29.30
Domain	PH_dom-like	PHLDB3 RGPD2 PHLDB1 GRK3 RASA2 KALRN RASA4 MCF2L2 RASA4B PLEKHA5 PPP4R3A	3.18e-06	426	84	11	IPR011993
Domain	PH	PHLDB3 PHLDB1 GRK3 RASA2 KALRN RASA4 MCF2L2 RASA4B PLEKHA5	4.37e-06	278	84	9	SM00233
Domain	PH_DOMAIN	PHLDB3 PHLDB1 GRK3 RASA2 KALRN RASA4 MCF2L2 RASA4B PLEKHA5	4.50e-06	279	84	9	PS50003
Domain	PH_domain	PHLDB3 PHLDB1 GRK3 RASA2 KALRN RASA4 MCF2L2 RASA4B PLEKHA5	4.64e-06	280	84	9	IPR001849
Domain	BTK	RASA2 RASA4 RASA4B	7.23e-06	9	84	3	SM00107
Domain	Znf_Btk_motif	RASA2 RASA4 RASA4B	7.23e-06	9	84	3	IPR001562
Domain	BTK	RASA2 RASA4 RASA4B	7.23e-06	9	84	3	PF00779
Domain	ZF_BTK	RASA2 RASA4 RASA4B	7.23e-06	9	84	3	PS51113
Domain	PH	PHLDB3 PHLDB1 GRK3 RASA2 KALRN RASA4 RASA4B PLEKHA5	8.84e-06	229	84	8	PF00169
Domain	TIF_eIF-1A_CS	EIF1AX EIF1AY	2.00e-05	2	84	2	IPR018104
Domain	RasGAP	RASA2 RASA4 RASA4B	3.08e-05	14	84	3	SM00323
Domain	TUDOR	TDRD5 TDRD15 TDRD12	3.08e-05	14	84	3	PF00567
Domain	RasGAP_CS	RASA2 RASA4 RASA4B	3.08e-05	14	84	3	IPR023152
Domain	RasGAP	RASA2 RASA4 RASA4B	3.84e-05	15	84	3	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA2 RASA4 RASA4B	3.84e-05	15	84	3	PS00509
Domain	RAS_GTPASE_ACTIV_2	RASA2 RASA4 RASA4B	3.84e-05	15	84	3	PS50018
Domain	-	RASA2 RASA4 RASA4B	4.71e-05	16	84	3	1.10.506.10
Domain	-	RASA4 RASA4B	5.98e-05	3	84	2	4.10.1130.10
Domain	TIF_eIF-1A	EIF1AX EIF1AY	5.98e-05	3	84	2	PD005579
Domain	IF1A	EIF1AX EIF1AY	5.98e-05	3	84	2	PS01262
Domain	RasGAP_dom	RASA2 RASA4 RASA4B	6.82e-05	18	84	3	IPR001936
Domain	S1_IF1_TYPE	EIF1AX EIF1AY	1.19e-04	4	84	2	PS50832
Domain	eIF1a	EIF1AX EIF1AY	1.19e-04	4	84	2	SM00652
Domain	RNA-binding_domain_S1_IF1	EIF1AX EIF1AY	1.19e-04	4	84	2	IPR006196
Domain	eIF-1a	EIF1AX EIF1AY	1.19e-04	4	84	2	PF01176
Domain	TIF_eIF-1A	EIF1AX EIF1AY	1.19e-04	4	84	2	IPR001253
Domain	TUDOR	TDRD5 TDRD15 TDRD12	1.46e-04	23	84	3	PS50304
Domain	AWS	NSD1 NSD3	1.98e-04	5	84	2	SM00570
Domain	AWS	NSD1 NSD3	1.98e-04	5	84	2	PS51215
Domain	AWS_dom	NSD1 NSD3	1.98e-04	5	84	2	IPR006560
Domain	Tudor	TDRD5 TDRD15 TDRD12	3.26e-04	30	84	3	IPR002999
Domain	ATP-grasp	ACACA SUCLG2	1.76e-03	14	84	2	IPR011761
Domain	IMPORTIN_B_NT	IPO5 KPNB1	1.76e-03	14	84	2	PS50166
Domain	ATP_GRASP	ACACA SUCLG2	1.76e-03	14	84	2	PS50975
Domain	-	ACACA SUCLG2	2.02e-03	15	84	2	3.30.1490.20
Domain	Post-SET_dom	NSD1 NSD3	2.30e-03	16	84	2	IPR003616
Domain	PostSET	NSD1 NSD3	2.30e-03	16	84	2	SM00508
Domain	POST_SET	NSD1 NSD3	2.30e-03	16	84	2	PS50868
Domain	Importin-beta_N	IPO5 KPNB1	2.60e-03	17	84	2	IPR001494
Domain	ATP_grasp_subdomain_1	ACACA SUCLG2	2.92e-03	18	84	2	IPR013815
Domain	-	ACACA SUCLG2	2.92e-03	18	84	2	3.30.470.20
Domain	Zinc_finger_PHD-type_CS	NSD1 CHD3 NSD3	3.14e-03	65	84	3	IPR019786
Domain	PWWP	NSD1 NSD3	3.60e-03	20	84	2	SM00293
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PHLDB3 PHLDB1 POLR1A ADSS2 RUVBL1 ACACA RASA2 MAGED2 UBE3A P4HB PSMA3 EIF5B PLEKHA5 CCT7 NOL10 CHD7 LMNB2 PRPF38A SUCLG2 AQR KPNB1	1.37e-11	1353	87	21	29467282
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	IPO5 KNTC1 POLR1A ADSS2 RUVBL1 ACACA MLEC MAGED2 P4HB PSMA3 NEMF RBM15B EIF5B CCT7 NOL10 LMNB2 GNAS AQR KPNB1	1.89e-09	1425	87	19	30948266
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IPO5 POLR1A ACACA P4HB ANXA11 USP24 NSD1 EIF5B NOL10 CHD7 LMNB2 AQR KPNB1	9.18e-09	653	87	13	22586326
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	IPO5 HSPA12A RUVBL1 MAGED2 ANXA11 USP24 CCT7 CHD3 CHD7 GNAS AQR KPNB1	2.44e-08	582	87	12	20467437
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	AMPD1 ATP6V1C1 ADSS2 RUVBL1 ACACA MAGED2 PTGR1 P4HB EIF1AX PSMA3 ANXA11 EIF5B CCT7 GNAS SUCLG2 MMUT KPNB1	4.23e-08	1367	87	17	32687490
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	IPO5 RUVBL1 ACACA MAGED2 P4HB PSMA3 USP24 EIF5B CCT7 LMNB2 PPP4R3A KPNB1	6.64e-08	638	87	12	33239621
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	RUVBL1 MAGED2 P4HB RBM15B EIF5B PLEKHA5 CCT7 NOL10 LMNB2 GNAS ITGA4 SQOR ITIH2 AQR NSD3 KPNB1	8.16e-08	1257	87	16	36526897
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	IPO5 KNTC1 ATP6V1C1 ADSS2 RUVBL1 ACACA MAGED2 UBE3A P4HB EIF1AX PSMA3 USP24 EIF5B CCT7 ZZEF1 PPP4R3A KPNB1	1.03e-07	1455	87	17	22863883
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ATP6V1C1 POLR1A MLEC P4HB EIF1AX VPS45 RBM15B NSD1 EIF5B CCT7 NOL10 CHD7 PRPF38A SQOR AQR GGCX NSD3	1.55e-07	1497	87	17	31527615
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	HSPA12A POLR1A RUVBL1 NSD1 EIF5B CHD3 LMNB2 KPNB1	2.28e-07	250	87	8	33536335
Pubmed	Inhibition of nuclear import by the proapoptotic protein CC3.	IPO5 HTATIP2 KPNB1	3.01e-07	6	87	3	15282309
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	IPO5 RGPD2 POLR1A RUVBL1 ACACA MLEC MAGED2 UBE3A P4HB PSMA3 BAG4 CCT7 GNAS GGCX KPNB1	4.95e-07	1257	87	15	37317656
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	IPO5 RUVBL1 MAGED2 P4HB CEP162 NEMF CCT7 LMNB2 GNAS SUCLG2 SQOR KPNB1	7.69e-07	803	87	12	36517590
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	IPO5 P4HB PCDHGA9 EIF1AX ANXA11 BAG4 RBM15B EIF5B NOL10 PRPF38A AQR KPNB1	8.10e-07	807	87	12	22681889
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	IPO5 ADSS2 RUVBL1 ACACA MLEC P4HB PSMA3 EIF5B CCT7 GNAS ZZEF1 KPNB1	8.10e-07	807	87	12	30575818
Pubmed	HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection.	IPO5 LMNB2 KPNB1	8.39e-07	8	87	3	9436978
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	IPO5 POLR1A ADSS2 PTGR1 UBE3A PSMA3 EIF5B CCT7 CHD3 LMNB2 AQR PPP4R3A NSD3	1.42e-06	1014	87	13	32416067
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	RUVBL1 MAGED2 P4HB PSMA3 NEMF RBM15B CHD3 NOL10 CHD7 PRPF38A GNAS SUCLG2 SQOR ITIH2 GGCX	1.46e-06	1371	87	15	36244648
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	IPO5 PHLDB1 POLR1A RUVBL1 P4HB ANXA11 EIF5B CCT7 CHD3 LMNB2 GNAS AQR KPNB1	1.58e-06	1024	87	13	24711643
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	RUVBL1 KALRN P4HB EIF1AX NEMF RBM15B EIF5B CHD7 LMNB2 PRPF38A AQR NSD3 KPNB1	2.89e-06	1082	87	13	38697112
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	IPO5 ACACA MLEC GVINP1 P4HB PSMA3 USP46 GNAS SLC39A10 SQOR CSGALNACT1 NFU1 GGCX PPP4R3A KPNB1	2.93e-06	1451	87	15	30550785
Pubmed	Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation.	ACACA HTATIP2 EIF5B CHD3	3.80e-06	42	87	4	26362536
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	IPO5 ACACA MLEC P4HB DNAJA4 NEMF USP24 EIF5B CCT7 GNAS AQR RABGGTB NSD3 KPNB1	3.99e-06	1297	87	14	33545068
Pubmed	Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.	IPO5 ADSS2 RUVBL1 P4HB PSMA3 CCT7 LMNB2 PPP4R3A KPNB1	4.28e-06	495	87	9	28581483
Pubmed	eIF1A/eIF5B interaction network and its functions in translation initiation complex assembly and remodeling.	EIF1AX EIF5B	6.19e-06	2	87	2	27325746
Pubmed	Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria.	KALRN CHD7	6.19e-06	2	87	2	28152519
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	6.19e-06	2	87	2	11448776
Pubmed	Remarkable conservation of translation initiation factors: IF1/eIF1A and IF2/eIF5B are universally distributed phylogenetic markers.	EIF1AX EIF5B	6.19e-06	2	87	2	11699879
Pubmed	eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.	EIF1AX EIF5B	6.19e-06	2	87	2	35732735
Pubmed	MAGED2 Is Required under Hypoxia for cAMP Signaling by Inhibiting MDM2-Dependent Endocytosis of G-Alpha-S.	MAGED2 GNAS	6.19e-06	2	87	2	36010623
Pubmed	Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome.	PIEZO2 UBE3A	6.19e-06	2	87	2	36859399
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	6.19e-06	2	87	2	16041389
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	IPO5 POLR1A RUVBL1 MAGED2 CHD3 NOL10 CHD7 NSD3	6.77e-06	394	87	8	27248496
Pubmed	Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.	RUVBL1 NUAK1 MAGED2 P4HB PSMA3 CCT7 GNAS KPNB1	7.69e-06	401	87	8	25852190
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	KNTC1 POLR1A RUVBL1 MAGED2 PSMA3 ANXA11 CCT7 CHD3 SUCLG2 PPP4R3A KPNB1	8.71e-06	847	87	11	35235311
Pubmed	Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.	IPO5 RUVBL1 UBE3A FCN2 SQOR KPNB1	9.96e-06	195	87	6	17110338
Pubmed	CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.	IPO5 MAGED2 P4HB PSMA3 EIF5B CCT7 GNAS KPNB1	1.04e-05	418	87	8	35338135
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	IPO5 RUVBL1 ACACA P4HB DNAJA4 EIF1AX PSMA3 NEMF USP24 EIF5B CCT7 AQR RABGGTB KPNB1	1.07e-05	1415	87	14	28515276
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	PHLDB3 HSPA12A PHLDB1 ACACA PLEKHA5 USP46 ITGA4 SLC39A10	1.09e-05	421	87	8	36976175
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	IPO5 ADSS2 RUVBL1 MLEC MAGED2 USP24 EIF5B PLEKHA5 CCT7 KPNB1	1.12e-05	708	87	10	39231216
Pubmed	Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.	EIF1AX EIF5B EIF1AY	1.20e-05	18	87	3	12426392
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	IPO5 ADSS2 MLEC MAGED2 UBE3A P4HB PSMA3 USP24 CCT7 SUCLG2 KPNB1	1.22e-05	878	87	11	37223481
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ATP6V1C1 RUVBL1 MAGED2 PSMA3 RBM15B GNAS SQOR	1.41e-05	313	87	7	38270169
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	IPO5 TARS3 MLEC KALRN UBE3A VPS45 PSMA3 NEMF MCF2L2 CCT7 BRWD3 BICD1 KPNB1	1.82e-05	1285	87	13	35914814
Pubmed	The NSD family of protein methyltransferases in human cancer.	NSD1 NSD3	1.85e-05	3	87	2	25942451
Pubmed	Inhibition of nuclear import mediated by the Rev-arginine rich motif by RNA molecules.	IPO5 KPNB1	1.85e-05	3	87	2	12614157
Pubmed	The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties.	IPO5 KPNB1	1.85e-05	3	87	2	9430704
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	1.85e-05	3	87	2	25637021
Pubmed	Karyopherins and nuclear import.	IPO5 KPNB1	1.85e-05	3	87	2	11751052
Pubmed	The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors.	NSD1 NSD3	1.85e-05	3	87	2	35532818
Pubmed	Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes.	LRRC63 HSPA12A	1.85e-05	3	87	2	17903304
Pubmed	Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners.	EIF1AX EIF5B	1.85e-05	3	87	2	12569173
Pubmed	Nuclear targeting of proteins: how many different signals?	IPO5 KPNB1	1.85e-05	3	87	2	10822175
Pubmed	The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.	EIF1AX EIF1AY	1.85e-05	3	87	2	24319994
Pubmed	Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation.	EIF1AX SUCLG2 EIF1AY	2.25e-05	22	87	3	30951662
Pubmed	LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.	ACACA ANXA11 EIF5B SQOR	2.34e-05	66	87	4	36398858
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ACACA MAGED2 PSMA3 USP24 RBM15B EIF5B CHD3 CHD7 PRPF38A PPP4R3A	2.40e-05	774	87	10	15302935
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	MLEC UBE3A LMNB2 GNAS BICD1	2.69e-05	139	87	5	25476789
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	RUVBL1 MLEC MAGED2 P4HB EIF1AX RALYL CCT7 LMNB2 PRPF38A KPNB1	2.74e-05	786	87	10	29128334
Pubmed	The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.	MAGED2 PSMA3 EIF5B KPNB1	3.12e-05	71	87	4	29346117
Pubmed	Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.	IPO5 ACACA CCT7 KPNB1	3.30e-05	72	87	4	36376293
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	IPO5 RUVBL1 P4HB DNAJA4 EIF5B CCT7 SLC39A10 KPNB1	3.43e-05	494	87	8	26831064
Pubmed	Testicular expression of TDRD1, TDRD5, TDRD9 and TDRD12 in azoospermia.	TDRD5 TDRD12	3.70e-05	4	87	2	32059713
Pubmed	Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1.	IPO5 KPNB1	3.70e-05	4	87	2	16704975
Pubmed	Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.	RASA4 RASA4B	3.70e-05	4	87	2	21460216
Pubmed	The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals.	IPO5 KPNB1	3.70e-05	4	87	2	9891055
Pubmed	Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo.	EIF1AX EIF5B	3.70e-05	4	87	2	12514125
Pubmed	Subcellular distribution of importins correlates with germ cell maturation.	IPO5 KPNB1	3.70e-05	4	87	2	17654710
Pubmed	The l2 minor capsid protein of human papillomavirus type 16 interacts with a network of nuclear import receptors.	IPO5 KPNB1	3.70e-05	4	87	2	15507604
Pubmed	Human eIF5 and eIF1A Compete for Binding to eIF5B.	EIF1AX EIF5B	3.70e-05	4	87	2	30211544
Pubmed	Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.	RASA4 RASA4B	3.70e-05	4	87	2	16234249
Pubmed	Histone and DNA binding ability studies of the NSD subfamily of PWWP domains.	NSD1 NSD3	3.70e-05	4	87	2	34271259
Pubmed	FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy.	ATP6V1C1 P4HB PSMA3 LMNB2 SUCLG2 KPNB1	3.86e-05	248	87	6	32963011
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	RUVBL1 ACACA MAGED2 EIF5B CHD3 CARNMT1 LMNB2 GNAS PPP4R3A	3.92e-05	655	87	9	35819319
Pubmed	Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.	IPO5 RUVBL1 PSMA3 CCT7 PPP4R3A KPNB1 EIF1AY	4.62e-05	377	87	7	25147182
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	TDRD5 TDRD15 RGPD2 MLEC MAGED2 P4HB BAG4 CCT7 CHD3 KPNB1	4.98e-05	844	87	10	25963833
Pubmed	Proteomic analysis identifies novel binding partners of BAP1.	RUVBL1 MAGED2 GNAS KPNB1	5.00e-05	80	87	4	34591877
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	RUVBL1 TXNL4B NSD1 EIF5B CHD3 NOL10 NSD3 KPNB1	5.84e-05	533	87	8	30554943
Pubmed	The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1.	IPO5 KPNB1	6.16e-05	5	87	2	10228156
Pubmed	In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.	NSD1 NSD3	6.16e-05	5	87	2	25494638
Pubmed	Multiple pathways contribute to nuclear import of core histones.	IPO5 KPNB1	6.16e-05	5	87	2	11493596
Pubmed	Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.	NSD1 NSD3	6.16e-05	5	87	2	39390582
Pubmed	Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.	IPO5 KPNB1	6.16e-05	5	87	2	27528606
Pubmed	Intranuclear binding by the HIV-1 regulatory protein VPR is dependent on cytosolic factors.	IPO5 KPNB1	6.16e-05	5	87	2	10772949
Pubmed	Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations.	MAGED2 GNAS	6.16e-05	5	87	2	27120771
Pubmed	Characterization of HIV-1 vpr nuclear import: analysis of signals and pathways.	IPO5 KPNB1	6.16e-05	5	87	2	9817747
Pubmed	Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex.	IPO5 KPNB1	6.16e-05	5	87	2	9621063
Pubmed	Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta.	IPO5 KPNB1	6.16e-05	5	87	2	9405152
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	HSPA12A P4HB CEP162 CCT7 NOL10 USP46 PRPF38A SLC39A10 PPP4R3A NSD3 KPNB1	6.16e-05	1049	87	11	27880917
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	IPO5 ADSS2 RUVBL1 ACACA P4HB NEMF EIF5B CCT7 GNAS NFU1 AQR KPNB1	6.36e-05	1247	87	12	27684187
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	IPO5 RUVBL1 MAGED2 BAG4 NEMF PLEKHA5 GNAS KPNB1	7.00e-05	547	87	8	37267103
Pubmed	Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.	HSPA12A RUVBL1 P4HB EIF1AX EIF5B CCT7 GNAS KPNB1	8.03e-05	558	87	8	35063084
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	AMPD1 RUVBL1 P4HB BAG4 EIF5B CCT7 GGCX KPNB1 EIF1AY	8.53e-05	725	87	9	27025967
Pubmed	Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action.	MAGED2 UBE3A PSMA3 CCT7	8.63e-05	92	87	4	35530310
Pubmed	MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.	RUVBL1 PSMA3 ANXA11 CCT7 GNAS ITGA4 ITIH2 KPNB1	8.76e-05	565	87	8	20458337
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RGPD2 ACACA USP24 PLEKHA5 CHD3 CHD7 EIF1AY	8.81e-05	418	87	7	34709266
Pubmed	In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics.	TDRD5 EIF1AX EIF5B EIF1AY	9.00e-05	93	87	4	25211037
Pubmed	Genetic variation associated with circulating monocyte count in the eMERGE Network.	PTGR1 ITGA4	9.22e-05	6	87	2	23314186
Pubmed	Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage.	AMPD1 ADSS2	9.22e-05	6	87	2	29079593
Pubmed	Structural basis for the nuclear export activity of Importin13.	EIF1AX EIF1AY	9.22e-05	6	87	2	23435562
Interaction	SLFN11 interactions	HSPA12A POLR1A RUVBL1 ACACA NSD1 EIF5B CCT7 CHD3 LMNB2 KPNB1	4.56e-06	376	86	10	int:SLFN11
Interaction	CIT interactions	IPO5 POLR1A RUVBL1 MAGED2 KALRN P4HB RALYL EIF5B CHD3 NOL10 LMNB2 PRPF38A GNAS ITGA4 ZZEF1 SQOR AQR BICD1 KPNB1	8.92e-06	1450	86	19	int:CIT
Interaction	MCM2 interactions	TDRD5 TDRD15 RGPD2 RUVBL1 ACACA MLEC NUAK1 MAGED2 UBE3A P4HB BAG4 CCT7 CHD3 ITGA4 PPP4R3A KPNB1	1.17e-05	1081	86	16	int:MCM2
Interaction	SIRT7 interactions	IPO5 POLR1A ACACA P4HB ANXA11 USP24 NSD1 EIF5B NOL10 CHD7 LMNB2 AQR KPNB1	1.54e-05	744	86	13	int:SIRT7
Interaction	KIF23 interactions	IPO5 RUVBL1 NUAK1 MAGED2 CDKL2 P4HB RALYL NSD1 EIF5B CHD3 NOL10 LMNB2 PRPF38A GNAS KPNB1	2.79e-05	1031	86	15	int:KIF23
Interaction	AGR2 interactions	IPO5 ADSS2 RUVBL1 ACACA MLEC PTGR1 P4HB PSMA3 NSD1 EIF5B CCT7 GNAS ZZEF1 KPNB1	3.86e-05	934	86	14	int:AGR2
Interaction	BIRC3 interactions	IPO5 KNTC1 POLR1A ADSS2 RUVBL1 MLEC MAGED2 P4HB PSMA3 RBM15B EIF5B CCT7 NOL10 LMNB2 GNAS AQR KPNB1	4.11e-05	1334	86	17	int:BIRC3
Cytoband	8p11.23	BAG4 ADGRA2	2.31e-04	12	87	2	8p11.23
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA2 RASA4 RASA4B	3.15e-06	10	55	3	830
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PHLDB3 PHLDB1 GRK3 RASA2 RASA4B PLEKHA5	3.70e-05	206	55	6	682
GeneFamily	Tudor domain containing	TDRD5 TDRD15 TDRD12	1.92e-04	37	55	3	780
GeneFamily	DNA helicases	RUVBL1 CHD7	1.20e-03	17	55	2	1167
GeneFamily	Armadillo repeat containing\|Importins	IPO5 KPNB1	1.35e-03	18	55	2	596
GeneFamily	PWWP domain containing	NSD1 NSD3	2.02e-03	22	55	2	1147
GeneFamily	PHD finger proteins	NSD1 CHD3 NSD3	2.60e-03	90	55	3	88
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	NSD1 NSD3	4.79e-03	34	55	2	487
Coexpression	GSE28237_FOLLICULAR_VS_EARLY_GC_BCELL_DN	ADSS2 RUVBL1 ACACA PTGR1 CCT7 SUCLG2 RABGGTB	4.73e-06	200	87	7	M4885
Coexpression	ERWIN_COHEN_BLOOD_LIVE_VACCINE_TC_83_AGE_23_48YO_VACCINATED_VS_CONTROL_14DY_UP	UBE3A EIF1AX PSMA3 BAG4 NEMF ITGA4 SLC39A10 SUCLG2 NFU1 RABGGTB EIF1AY	1.70e-05	687	87	11	M41022
Coexpression	CAIRO_HEPATOBLASTOMA_CLASSES_UP	IPO5 KNTC1 RUVBL1 P4HB USP24 EIF5B CCT7 CHD7 RABGGTB KPNB1	3.56e-05	612	87	10	M4772
Coexpression	LEE_BMP2_TARGETS_DN	POLR1A RUVBL1 MLEC DNAJA4 EIF1AX USP24 CCT7 NOL10 CARNMT1 USP46 LMNB2 KPNB1	4.34e-05	904	87	12	M2325
Coexpression	GSE1740_UNSTIM_VS_IFNA_STIMULATED_MCSF_IFNG_DERIVED_MACROPHAGE_DN	GRK3 CCT7 LMNB2 ZZEF1 AQR NSD3	5.09e-05	197	87	6	M6152
Coexpression	LEE_BMP2_TARGETS_DN	POLR1A RUVBL1 MLEC DNAJA4 USP24 CCT7 NOL10 CARNMT1 USP46 LMNB2 KPNB1 EIF1AY	5.24e-05	922	87	12	MM1068
Coexpression	GSE8921_3H_VS_24H_TLR1_2_STIM_MONOCYTE_DN	HSPA12A PTGR1 EIF1AX RBM15B CHD7 CARNMT1	5.53e-05	200	87	6	M6425
Coexpression	GSE1925_CTRL_VS_24H_IFNG_STIM_IFNG_PRIMED_MACROPHAGE_DN	NSD1 ITGA4 SUCLG2 SQOR BRWD3 GGCX	5.53e-05	200	87	6	M6299
Coexpression	GSE27786_BCELL_VS_MONO_MAC_UP	RUVBL1 UBE3A PSMA3 CCT7 ZZEF1 CSGALNACT1	5.53e-05	200	87	6	M4817
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHLDB3 AP4E1 COL6A6 USP24 NOL10 KPNB1	8.17e-07	163	87	6	132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area\|World / Primary Cells by Cluster	HSPA12A GRK3 NUAK1 CDKL2 RALYL PLEKHA5	2.46e-06	197	87	6	79b9e7f2e8e33b3c547f716be5667156c48b0dfc
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area-33\|World / Primary Cells by Cluster	HSPA12A GRK3 NUAK1 CDKL2 RALYL PLEKHA5	2.46e-06	197	87	6	d20f29088e9afd8a960d6f680075c380e550f8a7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FBXO40 PIEZO2 KALRN MCF2L2 ADGRA2	1.14e-05	150	87	5	8645b9c7f9511ed6cc9afe04440c2873a3094150
ToppCell	Endothelial-B-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	PIEZO2 NUAK1 KALRN PCDHGA9 CSGALNACT1	1.81e-05	165	87	5	10087d8bd2985906ef19547fe77eb178ae5e1638
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 NUAK1 KALRN GNAS ADGRA2	2.09e-05	170	87	5	99dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 NUAK1 KALRN GNAS ADGRA2	2.09e-05	170	87	5	3a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 NUAK1 KALRN GNAS ADGRA2	2.09e-05	170	87	5	cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRK3 RASA2 CDKL2 USP24 USP46	2.40e-05	175	87	5	c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_1\|Classical_Monocyte / Disease condition and Cell class	GRK3 FCN2 SQOR PPP4R3A NSD3	2.40e-05	175	87	5	35ea2ed93538e6bf803029fcf7d9243f93e7733d
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_1\|COVID-19_Severe / Disease condition and Cell class	GRK3 FCN2 SQOR PPP4R3A NSD3	2.82e-05	181	87	5	0d07a67e8ee3bca687b378afbc4044434e63556d
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PIEZO2 KALRN TXNL4B ADGRA2 CSGALNACT1	3.21e-05	186	87	5	40070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 NUAK1 KALRN MCF2L2 ADGRA2	3.30e-05	187	87	5	15d6e158562d7d85af3ceaf955439b379c8fce81
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 NUAK1 KALRN MCF2L2 ADGRA2	3.30e-05	187	87	5	f62074b631fd45ad299c69d71b09267b04d656ee
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO2 NUAK1 KALRN MCF2L2 ADGRA2	3.38e-05	188	87	5	32f22a4d8cb98fd8b8fa0fbf28ef9266d711d081
ToppCell	droplet-Limb_Muscle-nan-3m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AP4E1 GRK3 KALRN RBM15B ZZEF1	3.47e-05	189	87	5	16a4c92dd7a0d60f3691bd3130a091a9a54730f1
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	PIEZO2 NUAK1 KALRN FCN2 SLC26A5	4.12e-05	196	87	5	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KALRN UBE3A RALYL PLEKHA5 GNAS	4.33e-05	198	87	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KNTC1 RGPD2 AMPD1 ITGA4 BICD1	4.43e-05	199	87	5	1bb02f41f3cc76a28581e38b0ca4c36b930b85b4
ToppCell	Megakaryocytic-erythropoietic-Erythro-cells-Basophilic_Erythroblast\|Megakaryocytic-erythropoietic / Lineage, cell class and subclass	IPO5 RUVBL1 PSMA3 CCT7 KPNB1	4.43e-05	199	87	5	6f159c1215439ec22374903124085746fa8da333
Drug	Mefloquine hydrochloride [51773-92-3]; Down 200; 9.6uM; MCF7; HT_HG-U133A	IPO5 UBE3A ANXA11 USP24 NSD1 MMUT KPNB1	8.61e-06	193	86	7	6205_DN
Drug	leukotoxin B (12,13-EODE); Up 200; 0.2uM; MCF7; HT_HG-U133A_EA	IPO5 ANXA11 NEMF EIF5B CHD3 LMNB2 RABGGTB	9.21e-06	195	86	7	1108_UP
Drug	Alverine citrate salt [5560-59-8]; Down 200; 8.4uM; HL60; HG-U133A	ATP6V1C1 UBE3A NEMF USP46 ZZEF1 RABGGTB BICD1	1.02e-05	198	86	7	1426_DN
Drug	Cytisine (-) [485-35-8]; Up 200; 21uM; HL60; HG-U133A	ATP6V1C1 MAGED2 CEP162 ITGA4 NSD3 BICD1 KPNB1	1.05e-05	199	86	7	1766_UP
Disease	uveal melanoma (implicated_via_orthology)	EIF1AX EIF1AY	8.01e-06	2	84	2	DOID:6039 (implicated_via_orthology)
Disease	Sotos syndrome 1 (implicated_via_orthology)	NSD1 NSD3	2.40e-05	3	84	2	DOID:0112103 (implicated_via_orthology)
Disease	orotate measurement	DNAJA4 TXNL4B	7.96e-05	5	84	2	EFO_0800642
Disease	sleep duration, low density lipoprotein cholesterol measurement	TDRD15 TXNL4B USP24 KPNB1	1.35e-04	91	84	4	EFO_0004611, EFO_0005271
Disease	immature granulocyte measurement	CHD7 ITGA4	1.67e-04	7	84	2	EFO_0803543
Disease	concentration of large LDL particles measurement	TDRD15 TXNL4B KPNB1	2.71e-04	44	84	3	EFO_0022160
Disease	cholesterol in medium VLDL measurement	TDRD15 TXNL4B KPNB1	2.71e-04	44	84	3	EFO_0022225
Disease	free cholesterol in very small VLDL measurement	TDRD15 TXNL4B KPNB1	3.30e-04	47	84	3	EFO_0022275
Disease	Methylmalonic acidemia	SUCLG2 MMUT	3.55e-04	10	84	2	C0268583
Disease	Macrocephaly	CHD3 BRWD3	4.33e-04	11	84	2	C0221355
Disease	Methylmalonic aciduria	SUCLG2 MMUT	4.33e-04	11	84	2	C1855119
Disease	phospholipids in IDL measurement	TDRD15 TXNL4B KPNB1	4.45e-04	52	84	3	EFO_0022164
Disease	total lipids in LDL measurement	TDRD15 TXNL4B KPNB1	4.45e-04	52	84	3	EFO_0022308
Disease	total lipids in large LDL	TDRD15 TXNL4B KPNB1	5.83e-04	57	84	3	EFO_0022163
Disease	cholesterol in large LDL measurement	TDRD15 TXNL4B KPNB1	5.83e-04	57	84	3	EFO_0021901
Disease	free cholesterol measurement, low density lipoprotein cholesterol measurement	TDRD15 TXNL4B USP24 KPNB1	6.44e-04	137	84	4	EFO_0004611, EFO_0008591
Disease	phospholipids in small LDL measurement	TDRD15 TXNL4B KPNB1	6.45e-04	59	84	3	EFO_0022297
Disease	total lipids in IDL	TDRD15 TXNL4B KPNB1	6.77e-04	60	84	3	EFO_0022161
Disease	low density lipoprotein cholesterol measurement, physical activity	TDRD15 TXNL4B KPNB1	8.95e-04	66	84	3	EFO_0003940, EFO_0004611
Disease	syndrome (implicated_via_orthology)	NSD1 NSD3	1.19e-03	18	84	2	DOID:225 (implicated_via_orthology)
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	TDRD15 TXNL4B USP24 CSGALNACT1 KPNB1	1.47e-03	291	84	5	EFO_0008317, EFO_0020946
Disease	age at menopause	ADSS2 ACACA PTGR1 CHD7 ADGRA2	1.73e-03	302	84	5	EFO_0004704
Disease	proprotein convertase subtilisin/kexin type 9 measurement	TDRD15 USP24	1.78e-03	22	84	2	EFO_0009312
Disease	thalamus volume	NUAK1 PLEKHA5 BICD1	1.86e-03	85	84	3	EFO_0006935
Disease	intermediate density lipoprotein measurement	TDRD15 TXNL4B KPNB1	1.99e-03	87	84	3	EFO_0008595
Disease	lipid measurement, lipoprotein measurement	TDRD15 TXNL4B KPNB1	2.19e-03	90	84	3	EFO_0004529, EFO_0004732
Disease	hematocrit	AP4E1 TDRD15 ACACA KALRN DNAJA4 TXNL4B CHD3 SLC39A10 TDRD12	2.32e-03	1011	84	9	EFO_0004348
Disease	cholesteryl ester measurement, intermediate density lipoprotein measurement	TDRD15 TXNL4B KPNB1	2.48e-03	94	84	3	EFO_0008595, EFO_0010351
Disease	lipid measurement, intermediate density lipoprotein measurement	TDRD15 TXNL4B KPNB1	2.63e-03	96	84	3	EFO_0004529, EFO_0008595

Protein segments in the cluster

Peptide	Gene	Start	Entry
ISKLLGEYEVIFKEQ	TDRD5	316	Q8NAT2
QYLEQEVEEFVGKKT	BAG4	391	O95429
GEFTVEKGLKQIDEY	AKAP14	71	Q86UN6
INEAVPQVKFYEEIK	GRK3	76	P35626
FDIYEIKEAIKGVGT	ANXA11	276	P50995
KIQAAEYGLVVLEEK	BICD1	31	Q96G01
NVVLQYGFKVEVEKE	CARNMT1	366	Q8N4J0
LTVVYFGKEEINEVK	CSGALNACT1	296	Q8TDX6
QKFLGYVDQIKELVE	ADGRA2	471	Q96PE1
FEVLVTEKYEVVKQE	GVINP1	1786	Q7Z2Y8
DVELIYEGVKYVLKV	ACACA	671	Q13085
REQEFVKIVGIKYEV	BRWD3	981	Q6RI45
FDIKVIEDIYEKEIV	AQR	41	O60306
IIKEVGADLVEAKYQ	AMPD1	406	P23109
EGEKFKLISQAYEVL	DNAJA4	41	Q8WW22
YLINGAEEKILEEFK	CHD7	1256	Q9P2D1
KEEYVIVNLVGKIAE	AP4E1	421	Q9UPM8
IINKVFEEKKYVELD	RASA4	371	O43374
VDIEAIFSKYGKIVG	RALYL	36	Q86SE5
AFEKYGIIEEVVIKR	RBM15B	356	Q8NDT2
DIKKGEFVNEYVGEL	NSD1	1961	Q96L73
IINKVFEEKKYVELD	RASA4B	371	C9J798
EGYIIAVKKFLDEIS	RASA2	576	Q15283
KALEDVDYVQTFKGL	PPP4R3A	626	Q6IN85
ETKLKGVIYFQAIEE	PHLDB3	571	Q6NSJ2
EDLVVGIYQQKFLKE	MAEL	246	Q96JY0
YSLEKVFGIQLKEID	MAGED2	326	Q9UNF1
FLYLQVKGEVEAKVE	HTATIP2	141	Q9BUP3
DVIYKGFEDGIVQLK	NFU1	191	Q9UMS0
VDEFYSKIEGQKIDL	NEMF	296	O60524
KLGFYFQSEDIKIEI	ITIH2	761	P19823
KEEGDYVLVLKFAEV	MLEC	116	Q14165
QVLEGEEIAYKFTPK	LMNB2	506	Q03252
LEELEQVVYKPQKFF	DDX58	446	O95786
EEIYIKEIKSIIDGY	MCF2L2	631	Q86YR7
FKVLVEDRVKLYGIE	PCDHGA9	106	Q9Y5G4
EKDYVKDLGIVVEGF	KALRN	1941	O60229
LVFKEDGQEYAQVIK	EIF1AY	26	O14602
AIQFGLDVELVYKVK	KNTC1	416	P50748
YIAVELPKFEESKNI	LRRC63	541	Q05C16
EKLLYKIFGEDFIEQ	HSPA12A	356	O43301
DVFSKYQLDKDGVVL	P4HB	191	P07237
TVLKPQFYEIKAGEE	NOL10	586	Q9BSC4
ELKEGFVEYTEQVVK	IPO5	691	O00410
INVIDVNKVVEYVKG	RABGGTB	111	P53611
ELLVGDVKYGKAVDV	CDKL2	171	Q92772
QVFVLKEGVDYRVKI	ARHGDIG	121	Q99819
KVADEAEKYNLVLGA	FCN2	211	Q15485
FKVAQYVVREEDKIE	CHD3	1286	Q12873
DQIAYVTGEKLYEIK	CEP162	831	Q5TB80
ALAIGGEFKKYLEVV	KPNB1	721	Q14974
ERDFVYGKLEAQEVK	FBXO40	331	Q9UH90
EQIGKAYIFSIDEKE	ITGA4	276	P13612
NKFLEEYDAVLKGLV	SLC39A10	486	Q9ULF5
GDVKETYKVIFVAQV	CFAP74	1566	Q9C0B2
VIKYKEGAVDDIFVE	COL6A6	206	A6NMZ7
DEKVAYLQKLGFDVV	PTGR1	176	Q14914
VLEGKIQYKEYIIEG	PTGR1	291	Q14914
LAQYNFILVVGEKEK	TARS3	746	A2RTX5
LDAFVEGVVKKVAQY	ATP6V1C1	61	P21283
IFGVKKYADALQEII	SQOR	236	Q9Y6N5
IEKEIKDVFAVYGIA	POLR1A	1621	O95602
VEEKYVDDKVLVFLV	TDRD15	1596	B5MCY1
EEGEKVLYSQGVKLF	RGPD2	1046	P0DJD1
TVEKVEKFGLYGLAE	TDRD12	926	Q587J7
YEEVKEIPGIKIFQI	SLC26A5	526	P58743
LNAIKLEEKGVYVQA	EIF5B	971	O60841
FLDKIDVIKQADYVP	GNAS	821	Q5JWF2
AAEFLKQVKPYVEEG	CCT7	101	Q99832
ISIYEVFENKDKIVI	NUAK1	116	O60285
EIKVGVAYKLDGEII	ADSS2	371	P30520
ELIFKEQIDIFEGIK	SUCLG2	186	Q96I99
QIFIVYFIAGVKKLD	GGCX	206	P38435
LKKQLYVEFEGEQGV	UBE3A	551	Q05086
IIGVEKKEGYVLYDL	PIEZO2	2006	Q9H5I5
VKQVITKEYELFEFR	VPS45	191	Q9NRW7
VVFGVEKLVLSKLYE	PSMA3	46	P25788
IIVEFIKNEDFKYVR	PRPF38A	86	Q8NAV1
TKLKGVIYFQAIEEV	PHLDB1	1296	Q86UU1
KKGEFVNEYVGELID	NSD3	1166	Q9BZ95
KVVNKYIDQGIAELV	RUVBL1	281	Q9Y265
IVEKIDAQAIEEFYG	USP46	331	P62068
KKVALTENYELVGVI	USP24	1946	Q9UPU5
AKDLAVDLIEKYVGQ	ZZEF1	986	O43149
ASIIIGYVVIKFNKD	SLC9C2	131	Q5TAH2
FKTKQDFIDLIEVIY	TXNL4B	106	Q9NX01
IEEKKALEAEKYGFQ	PLEKHA5	316	Q9HAU0
LVFKEDGQEYAQVIK	EIF1AX	26	P47813
IVGVNKYQLEKEDAV	MMUT	486	P22033