Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF729 ZFP28 ZNF12 SOX11 ZNF431 ZNF561 ZNF492 ZNF536 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF197 ZNF114

1.28e-1512442818GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF729 ZFP28 ZNF12 SOX11 ZNF431 ZNF561 ZNF492 ZNF536 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF197 ZNF114

1.87e-1512712818GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF729 ZFP28 ZNF12 SOX11 ZNF431 ZNF561 ZNF492 ZNF536 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF197 ZNF114

1.17e-1414122818GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF729 ZFP28 ZNF12 SOX11 ZNF431 ZNF561 ZNF492 ZNF536 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF197 ZNF114

2.07e-1414592818GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

ZNF729 ZNF536 ZNF85 ZNF493

9.78e-04320284GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

ZNF729 SOX11 ZNF85 ZNF493 ZNF197

9.81e-04560285GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

ZNF729 SOX11 ZNF85 ZNF493 ZNF197

1.03e-03566285GO:0001216
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

ZNF729 ZNF536 ZNF85 ZNF493

1.05e-03326284GO:0001217
MousePhenodecreased eosinophil cell number

ZNF729 ZNF85 ZNF493

1.11e-0484163MP:0005012
Domainzf-C2H2_6

ZNF729 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF197 ZNF114

7.05e-223142816PF13912
DomainKRAB

ZNF729 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF85 ZNF680 ZNF30 ZNF562 ZNF732 ZNF718 ZNF273 ZNF738 ZNF197 ZNF114

5.87e-213582816PS50805
DomainKRAB

ZNF729 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF85 ZNF680 ZNF30 ZNF562 ZNF732 ZNF718 ZNF273 ZNF738 ZNF197 ZNF114

5.87e-213582816PF01352
DomainKRAB

ZNF729 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF85 ZNF680 ZNF30 ZNF562 ZNF732 ZNF718 ZNF273 ZNF738 ZNF197 ZNF114

9.56e-213692816SM00349
DomainKRAB

ZNF729 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF85 ZNF680 ZNF30 ZNF562 ZNF732 ZNF718 ZNF273 ZNF738 ZNF197 ZNF114

9.99e-213702816IPR001909
DomainZINC_FINGER_C2H2_2

ZNF729 ZNF462 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF536 ZNF609 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF197 ZNF114

2.16e-207752819PS50157
DomainZINC_FINGER_C2H2_1

ZNF729 ZNF462 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF536 ZNF609 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF197 ZNF114

2.27e-207772819PS00028
DomainZnf_C2H2-like

ZNF729 ZNF462 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF536 ZNF609 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF197 ZNF114

3.58e-207962819IPR015880
DomainZnf_C2H2

ZNF729 ZNF462 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF536 ZNF609 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF197 ZNF114

4.43e-208052819IPR007087
DomainZnF_C2H2

ZNF729 ZNF462 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF536 ZNF609 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF197 ZNF114

4.75e-208082819SM00355
Domain-

ZNF729 ZNF462 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF536 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF197 ZNF114

9.22e-2067928183.30.160.60
Domainzf-C2H2

ZNF729 ZNF462 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF536 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF197 ZNF114

1.33e-196932818PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF729 ZNF462 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF536 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF197 ZNF114

1.36e-196942818IPR013087
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

ZNF729 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF738 ZNF197 ZNF114

6.14e-1113872516M734
PathwayREACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS_BY_KRAB_ZFP_PROTEINS

ZNF680 ZNF30 ZNF273

8.66e-04107253M48260
PathwayREACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS

ZNF680 ZNF30 ZNF273

1.96e-03142253M48257
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF561 ZNF680 ZNF562 ZNF493 ZNF718 ZNF273 ZNF738 ZNF197

1.31e-1218128837372979
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF729 ZNF85 ZNF493 ZNF718

7.87e-092928414563677
Pubmed

B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors.

ZNF561 ZNF562

1.87e-06328236717582
Pubmed

Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.

ZNF729 ZNF85 ZNF493

8.40e-06492839630514
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ZNF462 ZNF536 ZNF609 KIF15 ZMYM3

1.92e-0541828534709266
Pubmed

Functional analysis of the SRY-KRAB interaction in mouse sex determination.

ZNF729 ZNF493

2.80e-051028218588511
Pubmed

Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.

ZNF729 ZNF493

3.42e-051128215469996
Pubmed

Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.

ZNF729 ZNF493

4.85e-051328219850934
Pubmed

Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.

ZNF729 ZNF493

6.52e-051528215885501
Pubmed

Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.

ZNF85 ZNF114

7.45e-05162828467795
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ZNF536 ZNF609 ZMYM3

8.06e-051042839205841
Pubmed

Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.

ZNF12 ZNF273

1.30e-04212827865130
Pubmed

Interaction network of human early embryonic transcription factors.

ZNF462 ZNF536 ZNF609 ZMYM3

1.72e-0435128438297188
Pubmed

Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.

ZNF462 ZNF718

2.68e-043028220080650
Pubmed

Multiple genes encoding zinc finger domains are expressed in human T cells.

ZNF12 ZNF30

2.86e-04312822288909
Pubmed

Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.

SOX11 ZNF561 ZNF562

3.15e-0416528316107646
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF729 ZNF462 ZFP28 ZNF609 ZNF718

4.21e-0480828520412781
Pubmed

A census of human transcription factors: function, expression and evolution.

ZNF12 SOX11 ZNF30 ZNF273 ZNF197

7.16e-0490828519274049
InteractionTRIM28 interactions

ZNF462 ZNF12 ZNF561 ZNF492 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF738 ZNF197 ZNF114

1.29e-1014742815int:TRIM28
InteractionZNF561 interactions

ZNF561 ZNF562

1.02e-0411282int:ZNF561
InteractionCBX5 interactions

ZNF462 ZNF562 ZNF718 ZMYM3 ZNF114

1.18e-04356285int:CBX5
InteractionLTBP2 interactions

ZNF12 ZNF431 ZNF273

2.20e-0485283int:LTBP2
InteractionGSC interactions

ZNF462 ZNF536 ZNF609

2.35e-0487283int:GSC
InteractionZNF562 interactions

ZNF561 ZNF562

3.14e-0419282int:ZNF562
InteractionCRX interactions

ZNF462 ZNF536 ZNF609 ZMYM3

3.98e-04254284int:CRX
Cytoband19p12

ZNF729 ZNF431 ZNF492 ZNF85 ZNF493 ZNF738

1.74e-119028619p12
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF729 ZNF431 ZNF492 ZNF85 ZNF493 ZNF738

1.12e-10122286chr19p12
Cytoband7q11.21

ZNF680 ZNF273

1.18e-03832827q11.21
Cytoband4p16.3

ZNF732 ZNF718

1.24e-03852824p16.3
CytobandEnsembl 112 genes in cytogenetic band chr4p16

ZNF732 ZNF718

8.10e-03222282chr4p16
Cytoband19p13.2

ZNF561 ZNF562

8.60e-0322928219p13.2
CytobandEnsembl 112 genes in cytogenetic band chr7q11

ZNF680 ZNF273

1.19e-02271282chr7q11
CytobandEnsembl 112 genes in cytogenetic band chr3p21

KIF15 ZNF197

1.59e-02316282chr3p21
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF729 ZNF462 ZFP28 ZNF12 ZNF431 ZNF561 ZNF492 ZNF536 ZNF609 ZNF85 ZNF680 ZNF30 ZNF562 ZNF493 ZNF732 ZNF718 ZNF273 ZNF197 ZNF114

9.63e-22718261928
CoexpressionZWANG_DOWN_BY_2ND_EGF_PULSE

ZNF431 ZNF30 ZNF493 ZNF732 ZNF738

2.08e-05321285M2615
CoexpressionCARRILLOREIXACH_HEPATOBLASTOMA_VS_NORMAL_UP

ZNF431 ARMC9 KIF15 ZNF273 ZNF738 ZMYM3 CAPN11

3.25e-05891287M45033
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ZNF492 ZNF536 KIF15 ZNF732

6.20e-06193284516ea2c12bdc7a5dc676159d627e36f6abe13ef0
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ZNF492 ZNF536 KIF15 ZNF732

6.20e-06193284bbdfda6665941cfa1965418bb91ef9ff43b1326f
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ZNF492 ZNF536 KIF15 ZNF732

6.33e-06194284590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ZNF492 KIF15 ZNF732 ZNF718

6.59e-06196284df366d76ea55f49e349d622effa57c1535df8400
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8|TCGA-Bladder / Sample_Type by Project: Shred V9

ZNF680 ZNF562 ZNF738

1.12e-041502831aa9320d97ff10994ea024751790524fe133aba9
ToppCell10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-pDC_progenitor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ZNF30 CAPN11 ZNF114

1.14e-041512838ffd71d847fe1aeebe7f43c4b6ca73efb19d6041
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-2|TCGA-Lung / Sample_Type by Project: Shred V9

ZNF729 ZNF492 KIF15

1.31e-041582839dea15b28f64206bac0e785df6f36a2cc9010ac7
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX11 ZNF536 ADAMTS1

1.33e-0415928351a7322efead3d4978e8f9fef71302bfae96edd7
ToppCellmild_COVID-19_(asymptomatic)-RBC|World / disease group, cell group and cell class (v2)

CATSPERE ZNF85 ZNF680

1.59e-041692832bda6ab3f32e05cb7daf91eb7c39b4fcc9ae91bb
ToppCellmild_COVID-19_(asymptomatic)-RBC|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

CATSPERE ZNF85 ZNF680

1.65e-0417128378491478ba65bad45238fe114f5251b2adea323d
ToppCellMS-Treg-naive_CD4|MS / Condition, Cell_class and T cell subcluster

ZNF431 ZNF85 ALG6

1.92e-041802837ca083616926d98420fa11a6e5ebc981623f79ac
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX11 ZNF431 ZNF738

2.01e-04183283af14da45267261e775dd6dab7a4c359b181e46f1
ToppCellCV-Healthy-7|CV / Virus stimulation, Condition and Cluster

ZNF561 ZNF680 ZNF273

2.04e-041842830e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCellCV-Healthy-7|Healthy / Virus stimulation, Condition and Cluster

ZNF561 ZNF680 ZNF273

2.08e-041852831979d189c204f4c2893e3170a514ee7d5523406c
ToppCellMesenchymal-myofibroblast_cell|World / Lineage, Cell type, age group and donor

SOX11 ZNF536 ADAMTS1

2.21e-0418928344e37f88137bb249933eb615235b2cf2ae7f3925
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF492 KIF15 ZNF732

2.25e-0419028331de1727822e9818652946dfb962daee77ffad68
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF536 ARMC9 ADAMTS1

2.28e-0419128308042952431ca1a6fd7dfc13f36eb28643979598
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ZNF462 SOX11 ZNF738

2.35e-04193283e477f5ddbb9d5878560998250ca0e1a5467953f4
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ZNF492 KIF15 ZNF732

2.42e-0419528356d8734d020b3da08a5aa9e67999706a9e023a99
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ZNF492 KIF15 ZNF732

2.42e-04195283b65463a804fed2d9a3be9e528ca8b9c98469bc86
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF536 ADAMTS1 ZNF732

2.50e-041972836d0d68d460243a0259ada93ebda40fa7b3088eeb
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ZNF462 SOX11 ZNF680

2.54e-041982833550798bfb9a426f3b28538a9778159bec2480d0
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

ZNF462 SOX11 ZNF536

2.54e-04198283de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-NK_CD56bright|Influenza_Severe / Disease, condition lineage and cell class

ZFP28 ADAMTS1 ZNF738

2.57e-04199283784e7e7ede2baa28ede600834813e6de2240bfdf
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX11 ZNF536 KIF15

2.57e-041992839940f347973bf976ee23fb4b1cf1f349d96c21df
Drugvinylene

ZNF462 ZFP28 ZNF492 ZNF536 ZNF197

1.11e-05245285CID000006326
Diseaseinterleukin 12 measurement

ZNF462 CAPN11

9.25e-0453252EFO_0004753
Diseasefactor VII activating protease measurement

ZNF609 ZNF197

9.96e-0455252EFO_0009368
Diseasevascular endothelial growth factor measurement

ZNF462 CAPN11

1.03e-0356252EFO_0004762
Diseasemacrophage inflammatory protein 1b measurement

KIF15 ZNF197

5.90e-03136252EFO_0008219
DiseaseNon-Small Cell Lung Carcinoma

ZNF462 ADAMTS1

7.69e-03156252C0007131
DiseaseIGF-1 measurement

ZNF462 ZNF12 ZNF536

7.89e-03488253EFO_0004627

Protein segments in the cluster

PeptideGeneStartEntry
KKFIAIKGFSKKGCH

CATSPERE

706

Q5SY80
FCFLLGKCFKKGLKG

ALG6

211

Q9Y672
KFKSFKTKGFGLDAC

CAPN11

601

Q9UMQ6
SKTCGKGYKKRSLKC

ADAMTS1

921

Q9UHI8
KEKAGAGKSFLCKCS

KIF15

151

Q9NS87
FSKECKIKGKPLCKT

ARMC9

31

Q7Z3E5
GAKTSKGSSKKCGKL

SOX11

156

P35716
TGEKPFKCKKCGKTF

ZNF30

591

P17039
KSKKTKKCGKSFTNF

ZNF561

251

Q8N587
TRHTGKKPFKCKKCG

ZNF431

196

Q8TF32
GKKSEKTKNCGKSFT

ZNF562

256

Q6V9R5
GKKLFKCNECKKTFT

ZFP28

416

Q8NHY6
TGKKPFKCKECGKSC

ZNF273

201

Q14593
TGDKTFKCKECGKSF

ZNF718

166

Q3SXZ3
TRHTGKKPFKCKKCG

ZNF738

196

Q8NE65
KKTFGCKKCGKIFSS

ZNF197

591

O14709
CKKCGKIFSSKSNFI

ZNF197

596

O14709
SKFSTKGLCKKKLSG

ZNF609

581

O15014
AAGFRCTFCKGKFKK

ZNF536

271

O15090
TGKKSFKCKECEKSF

ZNF492

136

Q9P255
TKHTGKKPFKCKKCG

ZNF493

46

Q6ZR52
KKKCSLCSFQSFSKK

ZNF462

1766

Q96JM2
KKPFKCTKCGKSFGM

ZNF85

171

Q03923
CSECGKSFCKKSKFI

ZNF12

271

P17014
KTPKCKGCGKAFKWS

ZNF732

556

B4DXR9
NTGKKVFKCKECGKS

ZNF680

176

Q8NEM1
KPSGKKTCTFCKKEI

ZMYM3

346

Q14202
KKKTFKCIKCSKSFF

ZNF729

176

A6NN14
KTCGKDFAKSSGLKK

ZNF114

391

Q8NC26