Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN4A SCN5A

3.37e-0426212GO:0005248
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SCN4A SCN5A SLC12A1

7.33e-04171213GO:0015081
GeneOntologyMolecularFunctionsodium channel activity

SCN4A SCN5A

1.35e-0352212GO:0005272
GeneOntologyMolecularFunctionscaffold protein binding

IL6ST SCN5A

4.25e-0393212GO:0097110
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

P2RX2 SCN4A SCN5A SLC12A1

4.62e-03664214GO:0008324
GeneOntologyMolecularFunctionmonoatomic cation channel activity

P2RX2 SCN4A SCN5A

5.31e-03343213GO:0005261
GeneOntologyMolecularFunctiontransmembrane transporter activity

P2RX2 ABCA8 SCN4A SCN5A SLC12A1

6.57e-031180215GO:0022857
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

P2RX2 SCN4A SCN5A SLC12A1

8.61e-03793214GO:0015075
GeneOntologyMolecularFunctiontransporter activity

P2RX2 ABCA8 SCN4A SCN5A SLC12A1

9.49e-031289215GO:0005215
GeneOntologyMolecularFunctiongrowth factor binding

IL6ST SCN5A

1.16e-02156212GO:0019838
GeneOntologyMolecularFunctionmonoatomic ion channel activity

P2RX2 SCN4A SCN5A

1.18e-02459213GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SCN4A SCN5A SLC12A1

1.22e-02465213GO:0046873
GeneOntologyBiologicalProcessneuronal action potential

P2RX2 SCN4A SCN5A

3.47e-0563213GO:0019228
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN4A SCN5A

1.30e-0417212GO:0001518
GeneOntologyCellularComponentendoplasmic reticulum membrane

TRAM2 REEP3 ZDHHC20 TMEM39B DIPK1A DOLK PIGC

1.84e-041293217GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

TRAM2 REEP3 ZDHHC20 TMEM39B DIPK1A DOLK PIGC

1.89e-041299217GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

TRAM2 REEP3 ZDHHC20 TMEM39B DIPK1A DOLK PIGC

2.16e-041327217GO:0042175
GeneOntologyCellularComponentsodium channel complex

SCN4A SCN5A

3.84e-0429212GO:0034706
HumanPhenoCongestive heart failure

XYLT2 IL6ST SCN4A SCN5A DOLK

2.28e-0527885HP:0001635
HumanPhenoApneic episodes in infancy

SCN4A SCN5A

9.65e-051082HP:0005949
HumanPhenoFetal onset

IL6ST SCN4A SCN5A SLC12A1

1.37e-0419884HP:0011461
HumanPhenoAbnormal atrioventricular valve physiology

XYLT2 IL6ST SCN4A SCN5A

1.89e-0421584HP:0031650
HumanPhenoHypokalemia

SCN4A SCN5A SLC12A1

1.90e-047983HP:0002900
DomainNa_channel_asu

SCN4A SCN5A

4.88e-0510202IPR001696
DomainNa_trans_assoc

SCN4A SCN5A

4.88e-0510202IPR010526
DomainNa_trans_assoc

SCN4A SCN5A

4.88e-0510202PF06512
DomainChannel_four-helix_dom

SCN4A SCN5A

1.68e-0357202IPR027359
Domain-

SCN4A SCN5A

1.68e-03572021.20.120.350
DomainIQ

SCN4A SCN5A

3.36e-0381202SM00015
DomainIQ_motif_EF-hand-BS

SCN4A SCN5A

4.12e-0390202IPR000048
DomainIQ

SCN4A SCN5A

4.40e-0393202PS50096
DomainIon_trans_dom

SCN4A SCN5A

6.53e-03114202IPR005821
DomainIon_trans

SCN4A SCN5A

6.53e-03114202PF00520
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN4A SCN5A

3.60e-0431132M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN4A SCN5A

3.83e-0432132M27455
Pubmed

Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants.

SCN4A SCN5A

3.47e-07221211834499
Pubmed

Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif.

SCN4A SCN5A

3.47e-07221230944319
Pubmed

Modulation of skeletal and cardiac voltage-gated sodium channels by calmodulin.

SCN4A SCN5A

1.04e-06321215746172
Pubmed

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.

SCN4A SCN5A

1.04e-06321220038812
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN4A SCN5A

3.47e-06521217724025
Pubmed

Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.

SCN4A SCN5A

9.70e-0682129412493
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN4A SCN5A

1.25e-05921216382098
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN4A SCN5A

1.25e-05921215746173
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

P2RX2 SCN4A SCN5A

7.88e-0513921316985003
Pubmed

Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.

SCN4A SCN5A

8.72e-052321216637659
Pubmed

Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.

PTCHD4 REEP3

4.88e-045421224823311
InteractionPOMK interactions

XYLT2 TMEM39B DIPK1A SCN4A

1.31e-04271204int:POMK
InteractionCHRNB2 interactions

P2RX2 TMEM39B DIPK1A

1.39e-04103203int:CHRNB2
InteractionKCNA6 interactions

HERC3 DOLK

1.58e-0419202int:KCNA6
InteractionSCN8A interactions

SCN4A SCN5A

1.76e-0420202int:SCN8A
InteractionTMEM219 interactions

DIPK1A SCN4A

2.34e-0423202int:TMEM219
InteractionTMEM62 interactions

HERC3 SCN4A

2.55e-0424202int:TMEM62
CytobandEnsembl 112 genes in cytogenetic band chr6p12

TRAM2 PTCHD4

1.92e-03142212chr6p12
GeneFamilySodium voltage-gated channel alpha subunits

SCN4A SCN5A

1.45e-0591221203
CoexpressionDOUGLAS_BMI1_TARGETS_UP

TRAM2 XYLT2 ZDHHC20 IL6ST EIF4E3 TMEM268

3.94e-06563216M15103
CoexpressionGSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_UP

TRAM2 XYLT2 DIPK1A TMEM268

1.78e-05200214M8042
CoexpressionZHENG_BOUND_BY_FOXP3

REEP3 ZDHHC20 DIPK1A IL6ST HERC3

3.84e-05498215M1741
CoexpressionZHENG_BOUND_BY_FOXP3

REEP3 ZDHHC20 DIPK1A IL6ST HERC3

4.18e-05507215MM1030
ComputationalGenes in the cancer module 400.

ABCA8 IL6ST

1.93e-0419122MODULE_400
DrugFlecainide

SCN4A SCN5A

8.10e-072212DB01195
DrugHydrochlorothiazide [58-93-5]; Down 200; 13.4uM; PC3; HT_HG-U133A

XYLT2 ITFG2 TMEM268 PIGC

2.68e-051932146625_DN
Drugprochlorperazine dimaleate salt; Down 200; 10uM; MCF7; HT_HG-U133A

TRAM2 XYLT2 ITFG2 PIGC

3.08e-052002145212_DN
Drugtetrapentylammonium

SCN4A SCN5A

1.09e-0417212CID000017248
DrugZonisamide

SCN4A SCN5A

1.09e-0417212DB00909
Drugmethanethiosulfonate

P2RX2 SCN4A SCN5A

1.13e-04103213CID004188587
Drugmoricizine

SCN4A SCN5A

1.23e-0418212CID000034632
DrugAC1L1MOZ

SCN4A SCN5A

2.80e-0427212CID000031958
DrugDPI 201-106

SCN4A SCN5A

3.02e-0428212CID000005190
Drugencainide

SCN4A SCN5A

3.02e-0428212CID000048040
Drugtocainide

SCN4A SCN5A

3.47e-0430212CID000038945
Drugoxcarbazepine

SCN4A SCN5A

3.47e-0430212CID000034312
DrugNSC15627

SCN4A SCN5A

4.47e-0434212CID000002073
Drugkojic acid

TRAM2 ZDHHC20 IL6ST TMEM217

5.52e-04424214ctd:C011890
Drugranolazine

SCN4A SCN5A

5.88e-0439212CID000056959
DrugLidocaone hydrochloride [73-78-9]; Down 200; 14.8uM; MCF7; HT_HG-U133A

XYLT2 IL6ST PIGC

6.81e-041902134421_DN
DrugBenoxinate hydrochloride [5987-82-6]; Down 200; 11.6uM; MCF7; HT_HG-U133A

XYLT2 ITFG2 PIGC

6.81e-041902134115_DN
DrugSulfamethazine sodium salt [1981-58-4]; Down 200; 13.4uM; PC3; HT_HG-U133A

XYLT2 IL6ST HERC3

6.81e-041902134322_DN
DrugChloroquine diphosphate [50-63-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A

XYLT2 ITFG2 IL6ST

6.81e-041902132869_DN
Drugheptanol

SCN4A SCN5A

6.82e-0442212CID000008129
DrugRapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A

ITFG2 TMEM39B PIGC

6.91e-041912135204_DN
Drugfluphenazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A

TRAM2 ITFG2 PIGC

6.91e-041912135234_DN
DrugDemeclocycline hydrochloride [64-73-3]; Down 200; 8uM; PC3; HT_HG-U133A

XYLT2 DIPK1A IL6ST

7.02e-041922134267_DN
Drugvinblastine sulfate; Up 200; 0.1uM; PC3; HT_HG-U133A

XYLT2 DIPK1A IL6ST

7.02e-041922137556_UP
DrugN-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; PC3; HT_HG-U133A

XYLT2 IL6ST PIGC

7.02e-041922134311_DN
DrugBisacodyl [603-50-9]; Down 200; 11uM; PC3; HT_HG-U133A

DIPK1A DOLK TMEM268

7.13e-041932134616_DN
DrugAstemizole [68844-77-9]; Down 200; 8.8uM; PC3; HT_HG-U133A

ITFG2 DIPK1A DOLK

7.13e-041932132049_DN
DrugFluvastatin sodium salt [93957-55-2]; Down 200; 9.2uM; PC3; HT_HG-U133A

ITFG2 DIPK1A IL6ST

7.13e-041932136691_DN
DrugClemizole hydrochloride [1163-36-6]; Down 200; 11uM; PC3; HT_HG-U133A

DIPK1A TMEM268 PIGC

7.13e-041932137371_DN
DrugAlexidine dihydrochloride [22573-93-9]; Down 200; 6.8uM; MCF7; HT_HG-U133A

TRAM2 ITFG2 DOLK

7.23e-041942134721_DN
DrugKynurenine, 3-hydroxy (R,S) [2147-61-7]; Down 200; 17.8uM; MCF7; HT_HG-U133A

XYLT2 ITFG2 HERC3

7.23e-041942135641_DN
Drugalpha-Santonin [481-06-1]; Up 200; 16.2uM; PC3; HT_HG-U133A

P2RX2 DIPK1A SCN4A

7.23e-041942134531_UP
DrugChlorpromazine hydrochloride [69-09-0]; Down 200; 11.2uM; MCF7; HT_HG-U133A

XYLT2 ITFG2 IL6ST

7.34e-041952131700_DN
DrugGabapentin [60142-96-3]; Up 200; 23.4uM; MCF7; HT_HG-U133A

ITFG2 IL6ST HERC3

7.34e-041952133472_UP
DrugCephalexin monohydrate [23325-78-2]; Up 200; 11uM; HL60; HT_HG-U133A

TRAM2 XYLT2 ITFG2

7.34e-041952131273_UP
DrugNefopam hydrochloride [23327-57-3]; Down 200; 13.8uM; HL60; HT_HG-U133A

XYLT2 TMEM268 PIGC

7.34e-041952132355_DN
DrugSulfapyridine [144-83-2]; Down 200; 16uM; MCF7; HT_HG-U133A

ITFG2 TMEM39B IL6ST

7.34e-041952136799_DN
DrugAmprolium hydrochloride [137-88-2]; Up 200; 12.6uM; MCF7; HT_HG-U133A

XYLT2 ITFG2 PIGC

7.45e-041962131479_UP
DrugAceclofenac [89796-99-6]; Up 200; 11.2uM; PC3; HT_HG-U133A

ITFG2 DIPK1A PIGC

7.45e-041962137269_UP
DrugCP-863187 [668981-07-5]; Up 200; 10uM; PC3; HT_HG-U133A

XYLT2 ITFG2 IL6ST

7.45e-041962137558_UP
DrugHydrocortisone base [50-23-7]; Down 200; 11uM; PC3; HT_HG-U133A

ITFG2 IL6ST PIGC

7.45e-041962136684_DN
DrugEpicatechin-(-) [154-23-4]; Down 200; 13.8uM; PC3; HT_HG-U133A

ITFG2 DIPK1A HERC3

7.45e-041962134594_DN
DrugEpitiostanol [2363-58-8]; Down 200; 13uM; HL60; HT_HG-U133A

HERC3 DOLK PIGC

7.45e-041962132922_DN
DrugAlverine citrate salt [5560-59-8]; Up 200; 8.4uM; PC3; HT_HG-U133A

ITFG2 HERC3 PIGC

7.56e-041972132110_UP
Drug2-propylpentanoic acid; Down 200; 500uM; MCF7; HT_HG-U133A

XYLT2 ITFG2 PIGC

7.56e-041972135600_DN
DrugThioridazine hydrochloride [130-61-0]; Down 200; 9.8uM; MCF7; HT_HG-U133A

TRAM2 XYLT2 IL6ST

7.56e-041972131486_DN
DrugScopolamin-N-oxide hydrobromide [6106-81-6]; Down 200; 10uM; MCF7; HT_HG-U133A

XYLT2 ITFG2 IL6ST

7.56e-041972135436_DN
DrugHarmaline hydrochloride dihydrate [6027-98-1]; Down 200; 14uM; PC3; HT_HG-U133A

XYLT2 ITFG2 IL6ST

7.56e-041972136623_DN
DrugChlorthalidone [77-36-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A

TRAM2 ITFG2 PIGC

7.56e-041972136800_DN
DrugHeliotrine [303-33-3]; Down 200; 12.8uM; HL60; HT_HG-U133A

XYLT2 DOLK PIGC

7.56e-041972132180_DN
DrugAceclofenac [89796-99-6]; Up 200; 11.2uM; PC3; HT_HG-U133A

ITFG2 IL6ST HERC3

7.56e-041972132117_UP
DrugSulfadiazine [68-35-9]; Down 200; 16uM; PC3; HT_HG-U133A

DIPK1A DOLK TMEM268

7.56e-041972135098_DN
DrugHydrocortisone base [50-23-7]; Up 200; 11uM; MCF7; HT_HG-U133A

ITFG2 SCN4A PIGC

7.68e-041982135284_UP
DrugZalcitabine [7481-89-2]; Down 200; 19uM; PC3; HT_HG-U133A

DIPK1A TMEM268 PIGC

7.68e-041982134215_DN
DrugNitrendipine [39562-70-4]; Up 200; 11uM; PC3; HT_HG-U133A

ABCA8 IL6ST HERC3

7.68e-041982136304_UP
Drug2-propylpentanoic acid; Down 200; 50uM; MCF7; HT_HG-U133A

ITFG2 DIPK1A PIGC

7.68e-041982135219_DN
DrugBromopride [4093-35-0]; Down 200; 11.6uM; HL60; HT_HG-U133A

XYLT2 HERC3 PIGC

7.68e-041982132182_DN
DrugTodralazine hydrochloride [3778-76-5]; Up 200; 14.8uM; PC3; HT_HG-U133A

XYLT2 DIPK1A SCN4A

7.68e-041982135087_UP
DrugMetampicillin sodium salt [6489-61-8]; Down 200; 10.4uM; MCF7; HT_HG-U133A

ITFG2 HERC3 PIGC

7.68e-041982132286_DN
DrugCefaclor [70356-03-5]; Down 200; 10.4uM; PC3; HT_HG-U133A

ITFG2 IL6ST PIGC

7.68e-041982136622_DN
DrugFelbinac [5728-52-9]; Down 200; 18.8uM; MCF7; HT_HG-U133A

ITFG2 HERC3 PIGC

7.68e-041982133398_DN
DrugBretylium tosylate [61-75-6]; Down 200; 9.6uM; PC3; HT_HG-U133A

ITFG2 DIPK1A HERC3

7.79e-041992136674_DN
DrugSulfamethizole [144-82-1]; Up 200; 14.8uM; MCF7; HT_HG-U133A

ITFG2 IL6ST PIGC

7.79e-041992136272_UP
DrugTorsemide [56211-40-6]; Up 200; 11.4uM; MCF7; HT_HG-U133A

ITFG2 SCN5A PIGC

7.79e-041992135476_UP
Drughaloperidol; Down 200; 10uM; MCF7; HT_HG-U133A

TRAM2 XYLT2 ITFG2

7.79e-041992136923_DN
DrugNitrofurantoin [67-20-9]; Down 200; 16.8uM; PC3; HT_HG-U133A

ITFG2 TMEM268 PIGC

7.79e-041992137373_DN
DrugSulfisoxazole [127-69-5]; Up 200; 15uM; HL60; HG-U133A

ITFG2 TMEM39B SCN5A

7.79e-041992131603_UP
DrugNiacin [59-67-6]; Down 200; 32.4uM; PC3; HT_HG-U133A

DIPK1A IL6ST TMEM268

7.79e-041992136702_DN
DrugMethimazole [60-56-0]; Down 200; 35uM; MCF7; HT_HG-U133A

XYLT2 ITFG2 IL6ST

7.90e-042002133432_DN
DrugNadolol [42200-33-9]; Down 200; 13uM; HL60; HT_HG-U133A

SCN5A DOLK PIGC

7.90e-042002133020_DN
DrugAminopurine, 6-benzyl [1214-39-7]; Up 200; 17.8uM; MCF7; HT_HG-U133A

ITFG2 P2RX2 SCN5A

7.90e-042002133623_UP
DrugSulfapyridine [144-83-2]; Down 200; 16uM; PC3; HT_HG-U133A

XYLT2 DIPK1A IL6ST

7.90e-042002137151_DN
Drugpilsicainide

SCN4A SCN5A

8.18e-0446212CID000004820
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN4A SCN5A

2.16e-0510212DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN4A SCN5A

2.16e-0510212DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN4A SCN5A

3.17e-0512212DOID:0060170 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

SCN4A SCN5A SLC12A1

2.05e-04163213DOID:1826 (implicated_via_orthology)
DiseaseFamilial dilated cardiomyopathy

SCN5A DOLK

4.48e-0444212C0340427
Diseasetotal cholesterol measurement, triglyceride measurement, low density lipoprotein cholesterol measurement, high density lipoprotein cholesterol measurement

TRAM2 PIGC

5.56e-0449212EFO_0004530, EFO_0004574, EFO_0004611, EFO_0004612

Protein segments in the cluster

PeptideGeneStartEntry
SWNTYYTNTEFVIVV

ARL5A

76

Q9Y689
AVALAVQAFYVQYKW

DOLK

46

Q9UPQ8
YVFQISVHEWYTAFS

HERC3

896

Q15034
YVTFNQKIYVYWEVQ

ITFG2

371

Q969R8
IYTVQTVQIFWSVYN

EIF4E3

76

Q8N5X7
FVWYVFIVQKSYQES

P2RX2

56

Q9UBL9
YSTVYFVNIEVWVEA

IL6ST

186

P40189
VFVGSWIIYVQYSTY

DIPK1A

36

Q5T7M9
YFTVGWNIFDFVVVI

SCN4A

1411

P35499
TAVSWVEQYYQFLKV

PTCHD4

546

Q6ZW05
YFTNSWNIFDFVVVI

SCN5A

1586

Q14524
WAAVITYVIEFFLYV

SLC12A1

626

Q13621
YQYWAVVFESSVVIQ

PIGC

46

Q92535
YWIVFALYTVIETVA

REEP3

41

Q6NUK4
IWSFCFYVVTVFSVA

ABCA8

1136

O94911
FAVVFYVVVWANIYS

TMEM268

106

Q5VZI3
FITFVVVWSYYAYVV

ZDHHC20

21

Q5W0Z9
VVWSYYAYVVELCVF

ZDHHC20

26

Q5W0Z9
VVFHFTSVIWCFYVV

TRAM2

121

Q15035
IYIVWIFFYETANVV

TMEM217

96

Q8N7C4
WFVLTRSFVEYVVYT

XYLT2

401

Q9H1B5
SAYYVAFVPVWFVKN

TMEM39B

296

Q9GZU3