Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	N-acetylglucosamine 6-O-sulfotransferase activity	CHST5 CHST6 CHST7	5.60e-06	7	110	3	GO:0001517
GeneOntologyMolecularFunction	medium-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	3.01e-05	2	110	2	GO:0140981
GeneOntologyMolecularFunction	16-hydroxypalmitate dehydrogenase activity	CYP4A11 CYP4A22	3.01e-05	2	110	2	GO:0103002
GeneOntologyMolecularFunction	keratan sulfotransferase activity	CHST5 CHST6	1.79e-04	4	110	2	GO:0045130
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4A11 CYP4A22	6.20e-04	7	110	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4A11 CYP4A22	6.20e-04	7	110	2	GO:0018685
Domain	Carbohydrate_sulfotransferase	CHST5 CHST6 CHST7	6.65e-06	7	109	3	IPR016469
Domain	WD40_repeat	GNB1L WDR76 SEC31B DCAF12L2 THOC6 WDR6 WDR90 HERC2 DCAF4L1	3.09e-05	272	109	9	IPR001680
Domain	EF_assoc_2	RHOT2 RHOT1	3.37e-05	2	109	2	PF08356
Domain	EF_assoc_1	RHOT2 RHOT1	3.37e-05	2	109	2	PF08355
Domain	MIRO_dom	RHOT2 RHOT1	3.37e-05	2	109	2	IPR020860
Domain	MIRO	RHOT2 RHOT1	3.37e-05	2	109	2	PS51423
Domain	Mt_Rho_GTPase	RHOT2 RHOT1	3.37e-05	2	109	2	IPR021181
Domain	EF_hand_assoc_2	RHOT2 RHOT1	3.37e-05	2	109	2	IPR013567
Domain	EF_hand_assoc_1	RHOT2 RHOT1	3.37e-05	2	109	2	IPR013566
Domain	WD_REPEATS_1	GNB1L WDR76 SEC31B DCAF12L2 THOC6 WDR6 WDR90 HERC2 DCAF4L1	3.67e-05	278	109	9	PS00678
Domain	WD_REPEATS_2	GNB1L WDR76 SEC31B DCAF12L2 THOC6 WDR6 WDR90 HERC2 DCAF4L1	3.77e-05	279	109	9	PS50082
Domain	WD_REPEATS_REGION	GNB1L WDR76 SEC31B DCAF12L2 THOC6 WDR6 WDR90 HERC2 DCAF4L1	3.77e-05	279	109	9	PS50294
Domain	WD40_repeat_dom	GNB1L UBR4 WDR76 SEC31B DCAF12L2 THOC6 WDR6 WDR90 DCAF4L1	6.12e-05	297	109	9	IPR017986
Domain	WD40	GNB1L WDR76 SEC31B DCAF12L2 THOC6 WDR6 WDR90 DCAF4L1	1.39e-04	259	109	8	PF00400
Domain	WD40	GNB1L WDR76 SEC31B DCAF12L2 THOC6 WDR6 WDR90 DCAF4L1	1.76e-04	268	109	8	SM00320
Domain	KRAB	ZNF132 ZKSCAN8 ZNF57 ZNF225 ZNF430 PRDM9 ZNF74 ZNF91 ZNF726	2.50e-04	358	109	9	PF01352
Domain	KRAB	ZNF132 ZKSCAN8 ZNF57 ZNF225 ZNF430 PRDM9 ZNF74 ZNF91 ZNF726	3.12e-04	369	109	9	SM00349
Domain	KRAB	ZNF132 ZKSCAN8 ZNF57 ZNF225 ZNF430 PRDM9 ZNF74 ZNF91 ZNF726	3.19e-04	370	109	9	IPR001909
Domain	ZnF_UBR1	UBR2 UBR4	6.95e-04	7	109	2	SM00396
Domain	ZF_UBR	UBR2 UBR4	6.95e-04	7	109	2	PS51157
Domain	zf-UBR	UBR2 UBR4	6.95e-04	7	109	2	PF02207
Domain	Znf_UBR	UBR2 UBR4	6.95e-04	7	109	2	IPR003126
Domain	-	GNB1L WDR76 SEC31B DCAF12L2 THOC6 WDR6 WDR90 DCAF4L1	7.49e-04	333	109	8	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	GNB1L WDR76 SEC31B DCAF12L2 THOC6 WDR6 WDR90 DCAF4L1	7.78e-04	335	109	8	IPR015943
Domain	Acyl-CoA_DH_CS	ACADM GCDH	1.18e-03	9	109	2	IPR006089
Domain	KRAB	ZNF132 ZKSCAN8 ZNF57 ZNF225 ZNF430 ZNF74 ZNF91 ZNF726	1.19e-03	358	109	8	PS50805
Domain	Sulfotransfer_1	CHST5 CHST6 CHST7	1.20e-03	36	109	3	PF00685
Domain	Sulfotransferase_dom	CHST5 CHST6 CHST7	1.20e-03	36	109	3	IPR000863
Domain	ACYL_COA_DH_1	ACADM GCDH	1.47e-03	10	109	2	PS00072
Domain	ACYL_COA_DH_2	ACADM GCDH	1.47e-03	10	109	2	PS00073
Domain	Acyl-CoA_dh_N	ACADM GCDH	1.79e-03	11	109	2	PF02771
Domain	MIRO-like	RHOT2 RHOT1	2.52e-03	13	109	2	IPR013684
Domain	-	ACADM GCDH	2.52e-03	13	109	2	1.10.540.10
Domain	Acyl-CoA_dh_1	ACADM GCDH	2.52e-03	13	109	2	PF00441
Domain	Roc	RHOT2 RHOT1	2.52e-03	13	109	2	PF08477
Domain	AcylCoA_DH/ox_N	ACADM GCDH	2.52e-03	13	109	2	IPR013786
Domain	CUB	LRP12 CUBN CSMD2	2.93e-03	49	109	3	PF00431
Domain	CUB	LRP12 CUBN CSMD2	3.10e-03	50	109	3	SM00042
Domain	Acyl-CoA_Oxase/DH_cen-dom	ACADM GCDH	3.37e-03	15	109	2	IPR006091
Domain	AcylCoA_DH/oxidase_NM_dom	ACADM GCDH	3.37e-03	15	109	2	IPR009100
Domain	Acyl-CoA_dh_M	ACADM GCDH	3.37e-03	15	109	2	PF02770
Domain	-	LRP12 CUBN CSMD2	3.47e-03	52	109	3	2.60.120.290
Domain	CUB	LRP12 CUBN CSMD2	3.66e-03	53	109	3	PS01180
Domain	AcylCo_DH/oxidase_C	ACADM GCDH	3.84e-03	16	109	2	IPR009075
Domain	Acyl_Trfase/lysoPLipase	PLA2G4E FASN	4.33e-03	17	109	2	IPR016035
Domain	Peptidase_S1A	PRSS41 PRSS22 TMPRSS5 PROZ	4.34e-03	113	109	4	IPR001314
Domain	CUB_dom	LRP12 CUBN CSMD2	4.50e-03	57	109	3	IPR000859
Domain	FN3	PRTG COL12A1 PTPRB UMODL1 MDGA1	4.60e-03	185	109	5	SM00060
Domain	TRYPSIN_DOM	PRSS41 PRSS22 TMPRSS5 PROZ	4.62e-03	115	109	4	PS50240
Domain	Tryp_SPc	PRSS41 PRSS22 TMPRSS5 PROZ	4.91e-03	117	109	4	SM00020
Domain	PIPLC_X_DOMAIN	ACAP1 PLCE1	5.41e-03	19	109	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	ACAP1 PLCE1	5.41e-03	19	109	2	IPR000909
Domain	Trypsin_dom	PRSS41 PRSS22 TMPRSS5 PROZ	5.53e-03	121	109	4	IPR001254
Domain	Trypsin	PRSS41 PRSS22 TMPRSS5 PROZ	5.53e-03	121	109	4	PF00089
Pathway	BIOCARTA_PLCE_PATHWAY	PTGER1 RAPGEF3 PLCE1	3.03e-05	11	82	3	MM1455
Pubmed	GlcNAc6ST3 is a keratan sulfate sulfotransferase for the protein-tyrosine phosphatase PTPRZ in the adult brain.	CHST5 CHST6 CHST7	3.24e-07	5	112	3	30867513
Pubmed	Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family.	CHST5 CHST6 CHST7	1.13e-06	7	112	3	11181564
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF493 ZKSCAN8 ZNF57 ZNF430 ZNF74 ZNF91 ZNF726	2.10e-06	181	112	7	37372979
Pubmed	Sulfation of the human immunodeficiency virus envelope glycoprotein.	CHST5 CHST6 CHST7	3.84e-06	10	112	3	1433500
Pubmed	Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine.	CHST5 CHST6 CHST7	5.26e-06	11	112	3	8419650
Pubmed	Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.	CYP4A11 CYP4A22	1.03e-05	2	112	2	15611369
Pubmed	Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.	RHOT2 RHOT1	1.03e-05	2	112	2	19098100
Pubmed	20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.	CYP4A11 CYP4A22	1.03e-05	2	112	2	23825080
Pubmed	Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins.	RHOT2 RHOT1	1.03e-05	2	112	2	24256248
Pubmed	Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.	CYP4A11 CYP4A22	1.03e-05	2	112	2	16691295
Pubmed	The P450 gene superfamily: recommended nomenclature.	CYP4A11 CYP4A22	1.03e-05	2	112	2	3829886
Pubmed	Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta).	CHST5 CHST6	1.03e-05	2	112	2	11352640
Pubmed	Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O-sulfotransferase.	CHST5 CHST6	1.03e-05	2	112	2	16938851
Pubmed	Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.	CYP4A11 CYP4A22	1.03e-05	2	112	2	29277328
Pubmed	Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.	CYP4A11 CYP4A22	1.03e-05	2	112	2	21820496
Pubmed	Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.	CYP4A11 CYP4A22	1.03e-05	2	112	2	23641057
Pubmed	Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery.	RHOT2 RHOT1	1.03e-05	2	112	2	31562315
Pubmed	Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.	CYP4A11 CYP4A22	1.03e-05	2	112	2	20943934
Pubmed	The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.	CYP4A11 CYP4A22	1.03e-05	2	112	2	28912346
Pubmed	Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.	CYP4A11 CYP4A22	1.03e-05	2	112	2	24413902
Pubmed	Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis.	RHOT2 RHOT1	1.03e-05	2	112	2	12482879
Pubmed	AEBP1 down regulation induced cell death pathway depends on PTEN status of glioma cells.	AEBP1 PIK3CB	1.03e-05	2	112	2	31601918
Pubmed	The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.	CYP4A11 CYP4A22	1.03e-05	2	112	2	2766933
Pubmed	Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase.	RHOT2 RHOT1	1.03e-05	2	112	2	33132189
Pubmed	Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution.	RHOT2 RHOT1	1.03e-05	2	112	2	29311115
Pubmed	Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.	CYP4A11 CYP4A22	1.03e-05	2	112	2	8031839
Pubmed	Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.	CYP4A11 CYP4A22	1.03e-05	2	112	2	10860550
Pubmed	Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression.	NR2F6 RHOT1	1.03e-05	2	112	2	31324186
Pubmed	MRP4/ABCC4 expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux.	ABCC4 RAPGEF3	1.03e-05	2	112	2	32333821
Pubmed	Electron tomography reveals multiple self-association of chondroitin sulphate/dermatan sulphate proteoglycans in Chst5-null mouse corneas.	CHST5 CHST6	1.03e-05	2	112	2	21440637
Pubmed	Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.	CYP4A11 CYP4A22	1.03e-05	2	112	2	17112342
Pubmed	Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.	CYP4A11 CYP4A22	1.03e-05	2	112	2	11320253
Pubmed	Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism.	RHOT2 RHOT1	1.03e-05	2	112	2	30513825
Pubmed	Characterization of the CYP4A11 gene, a second CYP4A gene in humans.	CYP4A11 CYP4A22	1.03e-05	2	112	2	12464262
Pubmed	The role of RHOT1 and RHOT2 genetic variation on Parkinson disease risk and onset.	RHOT2 RHOT1	1.03e-05	2	112	2	32948353
Pubmed	High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.	CYP4A11 CYP4A22	1.03e-05	2	112	2	30088983
Pubmed	Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.	CYP4A11 CYP4A22	1.03e-05	2	112	2	15066132
Pubmed	Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities.	CHST6 CHST7	1.03e-05	2	112	2	10913333
Pubmed	Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene.	CHST5 CHST6	1.03e-05	2	112	2	11017086
Pubmed	Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.	CYP4A11 CYP4A22	1.03e-05	2	112	2	19208908
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF493 ZNF91 ZNF726	1.44e-05	15	112	3	15885501
Pubmed	Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.	TMEM237 INPP5K PIEZO1 ZKSCAN8 TMPRSS5 PRPF8 FASN WDR6 POLDIP2	1.99e-05	463	112	9	27503909
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	UBR4 FASN FBXO22 PLEC HERC2 SNTB2	2.86e-05	182	112	6	31067453
Pubmed	Preferential expression of sialyl 6'-sulfo N-acetyllactosamine-capped O-glycans on high endothelial venules in human peripheral lymph nodes.	CHST5 CHST6	3.08e-05	3	112	2	31148596
Pubmed	Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice.	CYP4A11 CYP4A22	3.08e-05	3	112	2	2354437
Pubmed	Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate.	CHST5 CHST6	3.08e-05	3	112	2	12218059
Pubmed	Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice.	RHOT2 RHOT1	3.08e-05	3	112	2	30856164
Pubmed	Mitotic redistribution of the mitochondrial network by Miro and Cenp-F.	RHOT2 RHOT1	3.08e-05	3	112	2	26259702
Pubmed	Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX.	RHOT2 RHOT1	3.08e-05	3	112	2	30111583
Pubmed	Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.	CYP4A11 CYP4A22	3.08e-05	3	112	2	8011168
Pubmed	Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.	RAPGEF3 PLCE1	3.08e-05	3	112	2	18957419
Pubmed	Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.	CYP4A11 CYP4A22	3.08e-05	3	112	2	28270609
Pubmed	Cofactors and metabolites as potential stabilizers of mitochondrial acyl-CoA dehydrogenases.	ACADM GCDH	3.08e-05	3	112	2	21968293
Pubmed	The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.	CYP4A11 CYP4A22	3.08e-05	3	112	2	1991046
Pubmed	Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke.	RAPGEF3 PLCE1	3.08e-05	3	112	2	25103224
Pubmed	Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.	CYP4A11 CYP4A22	3.08e-05	3	112	2	19713718
Pubmed	Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver.	CYP4A11 CYP4A22	3.08e-05	3	112	2	15313227
Pubmed	The Epac-Phospholipase Cε Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons.	RAPGEF3 PLCE1	3.08e-05	3	112	2	28209735
Pubmed	H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.	CYP4A11 CYP4A22	3.08e-05	3	112	2	37659685
Pubmed	Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal GlcNac 6-O-sulfotransferase both produce keratan sulfate.	CHST5 CHST6	3.08e-05	3	112	2	11278593
Pubmed	Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue.	CHST5 CHST6	3.08e-05	3	112	2	10491328
Pubmed	A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.	CYP4A11 CYP4A22	3.08e-05	3	112	2	9271096
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	PRTG ABCC4 SLC39A2 PIEZO1 WDR76 TMEM177 RAPGEF3 PKD1 LTN1 MSS51 HERC2 ZNF726 NUP160 RHOT1	3.71e-05	1215	112	14	15146197
Pubmed	Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.	CYP4A11 CYP4A22	6.14e-05	4	112	2	8334987
Pubmed	A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.	UBR2 UBR4	6.14e-05	4	112	2	16055722
Pubmed	The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking.	RHOT2 RHOT1	6.14e-05	4	112	2	16630562
Pubmed	PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.	RHOT2 RHOT1	6.14e-05	4	112	2	22078885
Pubmed	The substrate recognition domains of the N-end rule pathway.	UBR2 UBR4	6.14e-05	4	112	2	19008229
Pubmed	Mapping of the azh locus to mouse chromosome 4.	CYP4A11 CYP4A22	6.14e-05	4	112	2	1552159
Pubmed	Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.	CYP4A11 CYP4A22	6.14e-05	4	112	2	10049703
Pubmed	Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand Māori and Pacific Men.	ABCC4 SLC22A7	6.14e-05	4	112	2	28371506
Pubmed	Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response.	RHOT2 RHOT1	6.14e-05	4	112	2	34152608
Pubmed	Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.	CYP4A11 CYP4A22	6.14e-05	4	112	2	22159897
Pubmed	Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase.	RHOT2 RHOT1	6.14e-05	4	112	2	24995978
Pubmed	Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	6.14e-05	4	112	2	21161333
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	LRP12 UBR4 WDR6 LTN1 POLDIP2 HERC2 SNTB2	7.23e-05	313	112	7	38270169
Pubmed	Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.	CYP4A11 CYP4A22	1.02e-04	5	112	2	8363569
Pubmed	Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity.	ACADM GCDH	1.02e-04	5	112	2	25416781
Pubmed	Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	1.02e-04	5	112	2	20427718
Pubmed	Rho GTPases have diverse effects on the organization of the actin filament system.	RHOT2 RHOT1	1.02e-04	5	112	2	14521508
Pubmed	Mapping of guanylin to murine chromosome 4 and human chromosome 1p34-p35.	CYP4A11 CYP4A22	1.02e-04	5	112	2	7601480
Pubmed	Loss of Dendritic Complexity Precedes Neurodegeneration in a Mouse Model with Disrupted Mitochondrial Distribution in Mature Dendrites.	RHOT2 RHOT1	1.02e-04	5	112	2	27705781
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	UBR4 PRPF8 FBXO38 FASN PLEC NUP160 HSPB1	1.04e-04	332	112	7	32786267
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF493 ZNF91 ZNF726	1.12e-04	29	112	3	14563677
Pubmed	Organization of the distal end of mouse chromosome 4.	CYP4A11 CYP4A22	1.53e-04	6	112	2	3166417
Pubmed	Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism.	CYP4A11 CYP4A22	1.53e-04	6	112	2	28007964
Pubmed	HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport.	RHOT2 RHOT1	1.53e-04	6	112	2	19528298
Pubmed	Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.	RAPGEF3 PLCE1	1.53e-04	6	112	2	23540699
Pubmed	Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.	RHOT2 RHOT1	1.53e-04	6	112	2	27605430
Pubmed	Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice.	CYP4A11 CYP4A22	1.53e-04	6	112	2	11461119
Pubmed	Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells.	CYP4A11 CYP4A22	1.53e-04	6	112	2	8798505
Pubmed	Mouse uroporphyrinogen decarboxylase: cDNA cloning, expression, and mapping.	CYP4A11 CYP4A22	1.53e-04	6	112	2	8661721
Pubmed	Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans.	CHST5 CHST6	1.53e-04	6	112	2	17690104
Pubmed	Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity.	CYP4A11 CYP4A22	2.14e-04	7	112	2	12958197
Pubmed	Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.	CYP4A11 CYP4A22	2.14e-04	7	112	2	18648086
Pubmed	Molecular mapping of the mouse db mutation.	CYP4A11 CYP4A22	2.14e-04	7	112	2	1978328
Pubmed	The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex.	PRPF8 SNTB2	2.14e-04	7	112	2	12054535
Pubmed	Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling.	LTN1 HERC2	2.14e-04	7	112	2	36700049
Pubmed	Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma.	PIK3CB PIK3R5	2.14e-04	7	112	2	12507995
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NR2F6 PIEZO1 UBR4 RHOT2 IDUA FANCA FASN DEF6 PKD1 WDR90 PLEC HERC2	2.38e-04	1105	112	12	35748872
Cytoband	16p13.3	PRSS41 PRSS22 RHOT2 THOC6 PKD1 WDR90	3.33e-05	244	113	6	16p13.3
Cytoband	19p12	ZNF493 ZNF430 ZNF91 ZNF726	7.55e-05	90	113	4	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF493 ZNF430 ZNF91 ZNF726	2.44e-04	122	113	4	chr19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	PRSS41 PRSS22 RHOT2 THOC6 PKD1 WDR90	6.75e-04	426	113	6	chr16p13
GeneFamily	Miro like atypical Rho GTPases\|EF-hand domain containing	RHOT2 RHOT1	2.03e-05	2	82	2	392
GeneFamily	WD repeat domain containing	GNB1L WDR76 SEC31B DCAF12L2 THOC6 WDR6 WDR90 DCAF4L1	2.47e-05	262	82	8	362
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR2 UBR4	4.20e-04	7	82	2	785
GeneFamily	Sulfotransferases, membrane bound	CHST5 CHST6 CHST7	6.25e-04	37	82	3	763
GeneFamily	Acyl-CoA dehydrogenase family	ACADM GCDH	1.09e-03	11	82	2	974
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF132 ZNF493 ZKSCAN8 ZNF57 ZNF225 ZNF430 PRDM9 ZNF74 ZNF91 ZNF726	1.48e-03	718	82	10	28
GeneFamily	Proteases, serine	PRSS41 PRSS22 TMPRSS5	2.94e-03	63	82	3	738
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLA2G4E PLCE1	3.30e-03	19	82	2	832
ToppCell	facs-Kidney-nan-18m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLA-DMB GCDH CUBN SLC22A7 SARDH SLC38A3	5.77e-06	177	112	6	d4cd54c07f1e51b5485270348fb7195d53465027
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor3_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 TMEM63C FCGR1A IRAG2 PIK3R5	7.90e-06	187	112	6	23be50d81f4404a609dea821e1a66d221c0e0615
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A DEF6 IRAG2 PIK3R5	8.65e-06	190	112	6	081b7bc07b6e5685e8a91b9ae6c1141623723700
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A DEF6 IRAG2 PIK3R5	8.65e-06	190	112	6	912aa106581d1ed7e147c92f9a367e8e6b04052b
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A DEF6 IRAG2 PIK3R5	8.91e-06	191	112	6	bce138f067b8962ecef1ddec6511a3f142d81d78
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_proliferating_myeloid_(8)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A DEF6 IRAG2 PIK3R5	9.18e-06	192	112	6	b204ef6e05170855259b902829a1700094eb9159
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_proliferating_myeloid_(8)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A DEF6 IRAG2 PIK3R5	9.18e-06	192	112	6	7e7383093efaadceadd4d1f900c2d39cd690102e
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage1_(2)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A DEF6 IRAG2 PIK3R5	9.18e-06	192	112	6	4e3deefd30adb7bf1eba294610eed3d077aa9418
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CYP4A11 MAB21L4 CUBN SLC22A7 CYP4A22 PROZ	9.18e-06	192	112	6	3e1a4cb0d83efd502c8613d41a1692bdda5860ed
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage1_(2)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A DEF6 IRAG2 PIK3R5	9.46e-06	193	112	6	2684fa361baaa9dc7a18a39ed11c0759e78e4418
ToppCell	PCW_07-8.5-Hematologic_Myeloid\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A DEF6 IRAG2 PIK3R5	9.74e-06	194	112	6	260649f5c4aeaa9cbf5ed5ae5e9f293d75bb0457
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_proliferating_myeloid_(8)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A DEF6 IRAG2 PIK3R5	1.03e-05	196	112	6	3fd5567ea14193181929134c377e8a38fb4f47fd
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte1_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A DEF6 IRAG2 PIK3R5	1.09e-05	198	112	6	898be90c906ebc806a764ae6c21bbf84649b6b30
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-I_(AT1)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	COL12A1 MAB21L4 PIEZO1 MDGA1 FRMD3 PLCE1	1.13e-05	199	112	6	5a002d49a8b84c158f7b4d7a3e78e6a937757bb7
ToppCell	facs-Trachea-18m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_trachea\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NR2F6 SLC39A2 C10orf67 HFM1 PIK3R5	2.69e-05	139	112	5	96e6fed23e7a69f678f85e8e2fe77a7491586b4b
ToppCell	TCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Testicular_Germ_Cell_Tumor\|TCGA-Testes / Sample_Type by Project: Shred V9	MAB21L4 PRSS22 FAM83E IDUA LINC00269	4.68e-05	156	112	5	f9eb18a0f00de211fab36d7d88fcf08276d53dcc
ToppCell	PND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACAP1 HLA-DMB MRM1 SIT1 IRAG2	6.10e-05	165	112	5	66f0364098d82629aa2ec1dfe0c5ad23de7c2c12
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR2F6 PRTG MRM1 MDGA1 ALPK2	7.43e-05	172	112	5	3f784aed340b50ddbec3f7dc0a5279180d38a2bb
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Lymphocytic\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAP1 HLA-DMB PRSS41 PRSS22 IRAG2	7.43e-05	172	112	5	3ffe721f62c0d20c1d765ecb15ed4e1aa88099f7
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Lymphocytic-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAP1 HLA-DMB PRSS41 PRSS22 IRAG2	7.43e-05	172	112	5	2bbe3f601a56577d200aa7ba7031f7c19b988cc1
ToppCell	droplet-Pancreas-Exocrine-21m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRTG MAB21L4 AEBP1 UMODL1 PLCE1	7.84e-05	174	112	5	a0ccda8fd6f55251cdeff24cf66e72e4a31d2104
ToppCell	TCGA-Liver\|World / Sample_Type by Project: Shred V9	CYP4A11 SLC22A7 CYP4A22 PROZ SLC38A3	7.84e-05	174	112	5	452932f08cf53e5949672a025d78cecb874aa4b0
ToppCell	3'-Adult-SmallIntestine-Hematopoietic-B_cells-Memory_B\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACAP1 HLA-DMB ESPNL SIT1 IRAG2	8.50e-05	177	112	5	0d1c39e99144fdb9c7f6f98a1ade41c73db45b65
ToppCell	facs-Kidney-nan-18m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACADM GCDH CUBN SLC22A7 SARDH	8.50e-05	177	112	5	7f58286fc8797e9bdcf8ece0849f55680905955d
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CMKLR2 CSMD2 FCGR1A PIK3R5 ALPK2	8.96e-05	179	112	5	cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	COL12A1 PTCHD4 AEBP1 ALPK2 PLCE1	8.96e-05	179	112	5	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	normal_Lung-Myeloid_cells-CD207+CD1a+_LCs\|normal_Lung / Location, Cell class and cell subclass	ABCC4 HLA-DMB TRPM2 ALPK2 ACTL10	9.44e-05	181	112	5	b55dbcfae8c92d322071906831489830a22239b9
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-B_cells-CLP\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACAP1 SIT1 UMODL1 IRAG2 PIK3R5	9.44e-05	181	112	5	1110a0375189c034e6b02e6ebceb7084e4590114
ToppCell	wk_08-11-Hematologic-Myeloid-pre-pDC/DC5\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB SIT1 UMODL1 IRAG2 PIK3R5	9.69e-05	182	112	5	fec8a2d6d4099722b8e1bb41222108ed74268fcf
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	9.94e-05	183	112	5	24679153b654c148dbd572e9013c0a6e58718ada
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CYP4A11 GCDH CUBN SLC22A7 ALPK2	9.94e-05	183	112	5	85446581999cd66b171c4f69b7eb8b0bbbaa8617
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	COL12A1 MAB21L4 PIEZO1 MDGA1 FRMD3	1.02e-04	184	112	5	c7073d1b2c4fdb154d87678b92a0629c02116972
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	COL12A1 MAB21L4 PIEZO1 MDGA1 FRMD3	1.02e-04	184	112	5	1ed558a88215b248431c524ea16f13d9022ae98c
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL12A1 C10orf67 MAB21L4 FRMD3 PLCE1	1.05e-04	185	112	5	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	droplet-Liver-Npc-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRM1 AGBL3 PTPRB RAPGEF3 CHST7	1.07e-04	186	112	5	75258d88e23112fd1f0f7c71ef0366abb400d33e
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature-lymphatic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CMKLR2 TSPEAR PTCHD4 PTPRB CHST7	1.07e-04	186	112	5	5d94e6dd2c92e0c46badeb1e6eb54b69af855a66
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CMKLR2 TSPEAR PTCHD4 PTPRB CHST7	1.07e-04	186	112	5	1da52e13096dfe4eb08bd0e7461cb3809b3b3deb
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.10e-04	187	112	5	bde6b90955423eab6a91a0abe75d0a95a1f5330a
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_migrating_dendritic_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.13e-04	188	112	5	8fc15c8b78fdd1a578e34325011bc5a87a8aab31
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.13e-04	188	112	5	f4d11d06be46f13adbf36d94bc2bdcd14d0bfa75
ToppCell	ASK454-Endothelial-Lymphatic\|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq	SEC31B AGBL3 FANCA FBXO22 AEBP1	1.16e-04	189	112	5	316c857dec9383823e09f966bca62d52d933b141
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_macrophage\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.16e-04	189	112	5	a438c64a893d43f781ede42e1c7b615b74dc76ef
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte2_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.19e-04	190	112	5	e5625feb21915d4545cfad2659745ef180efcb1f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC4 CUBN SLC22A7 ALPK2 FRMD3	1.22e-04	191	112	5	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	droplet-Pancreas-PANCREAS-30m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIEZO1 PTPRB RAPGEF3 CHST7 HSPB1	1.22e-04	191	112	5	471205494b91be69926dc8159376132bcea0d9b5
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC4 CUBN SLC22A7 ALPK2 FRMD3	1.22e-04	191	112	5	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	PCW_05-06-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	GDF15 MAB21L4 PRSS22 TSPEAR FRMD3	1.22e-04	191	112	5	05731ece7867659c662f952812805f947032fe10
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte1_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.22e-04	191	112	5	367d300da3925e0a329271b5f19483a37265a878
ToppCell	PCW_05-06-Epithelial-Epithelial_neuroendo\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	GDF15 MAB21L4 PRSS22 TSPEAR FRMD3	1.28e-04	193	112	5	aa10924b203c71e65fdbd2b90ba131dbd362d8b1
ToppCell	PCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_neutrophils_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.28e-04	193	112	5	c9e3fefa8d68d0e2b954f85ce37813185ff98d84
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.28e-04	193	112	5	9a6c5b7c8e88cf7a261f8e052df1709d2c0a91f0
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ACAP1 DEF6 IRAG2 PIK3R5 SLC38A3	1.28e-04	193	112	5	afdf92ecace145407d57192dde5d0dac0bc37ee9
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_macrophage\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.31e-04	194	112	5	ef30baa19b7aa97b61dea916fc2e0f5cf49848d6
ToppCell	PCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_B-im_lymphoid_progenitor_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ACAP1 SIT1 DEF6 IRAG2 PIK3R5	1.31e-04	194	112	5	69f7bedf6f0be338e4317c22125e727fb82000fc
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage1_(2)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.31e-04	194	112	5	846b4170544cdf58b536fb7a5fd34b79b0b17993
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte1_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.31e-04	194	112	5	fad22d5cf62016cad979e6943e357106d8d2a4b4
ToppCell	PCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_Granulocytic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.31e-04	194	112	5	85c5d07189eb7bb413f708a3ca40de08af3cb106
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_proliferating_myeloid_(8)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.31e-04	194	112	5	b4401777b03773ddc04bf13236c9528027f928b7
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A DEF6 PIK3R5	1.34e-04	195	112	5	799992721369357484300fe218aff075154c3148
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A DEF6 PIK3R5	1.34e-04	195	112	5	e8fb552f9ab77b656c27abc66af523b56cd9f9ad
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.34e-04	195	112	5	518cc3baeb7cf2ad068692cbe85fd75be67f1872
ToppCell	PCW_05-06-Hematologic_Myeloid\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.37e-04	196	112	5	b2aee2f67da373a10b0c25e7797e30e3811543a8
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor1_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A DEF6 IRAG2	1.37e-04	196	112	5	ce3709adbde7559b40c964888935914f66003247
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NR2F6 GDF15 PRSS22 TMEM63C HSPB1	1.40e-04	197	112	5	ec08a971e8dd9ad69359896c60ad77ff8af08fd0
ToppCell	356C-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	COL12A1 MAB21L4 PIEZO1 MDGA1 PLCE1	1.40e-04	197	112	5	69d5b8588046d119b5dff9a7fd6f49e97e00a5b7
ToppCell	356C-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	COL12A1 MAB21L4 PIEZO1 MDGA1 PLCE1	1.40e-04	197	112	5	e6cbfa267eb2e05b441fd034786faae07bb0e081
ToppCell	Sepsis-Bac-SEP-Lymphocyte-T/NK-CD8+_T_naive\|Bac-SEP / Disease, condition lineage and cell class	ACAP1 AGBL3 FGF22 HSPB1 PLCE1	1.44e-04	198	112	5	a9a009e5eeb935232034635ad4a3c27d83c081ac
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HLA-DMB TRPM2 FCGR1A IRAG2 PIK3R5	1.44e-04	198	112	5	1d242fbe4ae3628103f6b6f910a7641bb1b75266
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NR2F6 GDF15 PRSS22 CHST6 HSPB1	1.44e-04	198	112	5	3cc9e671f596ef0829684018e4257571fefb6267
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABCC4 GDF15 TMEM63C IRAG2 PLCE1	1.44e-04	198	112	5	19d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCell	18-Distal-Immune\|Distal / Age, Tissue, Lineage and Cell class	ACAP1 HLA-DMB SIT1 DEF6 IRAG2	1.44e-04	198	112	5	e68d4a152f0d19fe161c75a0cb844f505b667b6b
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 AEBP1 RAPGEF3 ALPK2 PLCE1	1.47e-04	199	112	5	b9338b739162cd8e5661c9a4dcb41a31219b5723
ToppCell	LPS_IL1RA-Hematopoietic_Lymphocytic-B_cells-B-cells\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ACAP1 HLA-DMB DEF6 IRAG2 FAM53B	1.47e-04	199	112	5	0eb8c72edcd34fe0f7ab9438c9c872d63576ef3a
ToppCell	LPS_IL1RA-Hematopoietic_Lymphocytic-B_cells\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ACAP1 HLA-DMB DEF6 IRAG2 FAM53B	1.47e-04	199	112	5	2cdc8ae6357723b9e7c0c66be656e6f748a6aa2d
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-T-T_CD3\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ACAP1 TSPEAR SIT1 YDJC PIK3R5	1.47e-04	199	112	5	4be4527f351b701438a8bcb738229a06dbf8bc96
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-T-T_CD3-NKT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ACAP1 TSPEAR SIT1 YDJC PIK3R5	1.47e-04	199	112	5	d3dc52e1f0040763888f951a7c047db4a329a653
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL12A1 AEBP1 RAPGEF3 ALPK2 PLCE1	1.47e-04	199	112	5	c972d3036151403f26fa9d6271520639c281ab84
ToppCell	Tracheal-10x5prime-Stromal-Schwann-Schwann_Myelinating\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TMPRSS5 ARHGAP39 CUBN AGBL3 CNTF	1.47e-04	199	112	5	2b567b6fd8addf059bbf2b72c55a7647aefdc595
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Lymphocytic-B_cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ACAP1 HLA-DMB DEF6 IRAG2 FAM53B	1.51e-04	200	112	5	d124acbe5d46220850fe485ed78f032daddca5b1
ToppCell	LPS_anti-TNF-Hematopoietic_Lymphocytic-B_cells\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ACAP1 HLA-DMB DEF6 IRAG2 FAM53B	1.51e-04	200	112	5	2fb3cf5c7a03c3874390a111bba15203599d4859
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Lymphocytic-B_cells-B-cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ACAP1 HLA-DMB DEF6 IRAG2 FAM53B	1.51e-04	200	112	5	c07e37db9d50b91378d9c8355168745560cdbd25
ToppCell	11.5-Distal-Immune\|Distal / Age, Tissue, Lineage and Cell class	HLA-DMB FCGR1A DEF6 IRAG2 PIK3R5	1.51e-04	200	112	5	c9ed06ae7a8f5a88578c8269d762d8739ae79c7f
ToppCell	LPS_anti-TNF-Hematopoietic_Lymphocytic-B_cells-B-cells\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ACAP1 HLA-DMB DEF6 IRAG2 FAM53B	1.51e-04	200	112	5	4c8007a158f0f6b6fa259b25d2387b648bb2fc0d
Disease	Xerocytosis	PIEZO1 SLC4A1	4.05e-05	3	109	2	C0272051
Disease	Distal Hereditary Motor Neuropathy, Type II	FBXO38 HSPB1	8.07e-05	4	109	2	C3711384
Disease	metabolic acidosis (biomarker_via_orthology)	SLC4A1 SLC38A3	1.34e-04	5	109	2	DOID:0050758 (biomarker_via_orthology)
Disease	Spinal muscular atrophy, Jerash type	FBXO38 HSPB1	1.34e-04	5	109	2	C1854023
Disease	X-14939 measurement	CYP4A11 CYP4A22	2.01e-04	6	109	2	EFO_0800747
Disease	joint hypermobility measurement	PRTG COL12A1 PIEZO1	2.47e-04	33	109	3	EFO_0007905
Disease	focal segmental glomerulosclerosis (is_marker_for)	TMEM63C HSPB1	3.73e-04	8	109	2	DOID:1312 (is_marker_for)
Disease	sarcoma (is_implicated_in)	PTPRB HSPB1	3.73e-04	8	109	2	DOID:1115 (is_implicated_in)
Disease	tetradecanedioate measurement	CYP4A11 MDGA1	4.79e-04	9	109	2	EFO_0021057
Disease	X-21607 measurement	ACADM CYP4A11	7.28e-04	11	109	2	EFO_0800819
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	CYP4A11 CYP4A22	7.28e-04	11	109	2	DOID:0110861 (biomarker_via_orthology)
Disease	dodecanedioate measurement	CYP4A11 MDGA1	8.71e-04	12	109	2	EFO_0021054
Disease	hair colour measurement, hair morphology measurement	FANCA HERC2	8.71e-04	12	109	2	EFO_0007821, EFO_0007822
Disease	glutaroyl carnitine measurement	ACADM GCDH	1.03e-03	13	109	2	EFO_0021005
Disease	Malignant neoplasm of breast	NR2F6 ACAP1 ACADM INPP5K GNB1L UBR4 CUBN RHD FASN PIK3CB HERC2	2.10e-03	1074	109	11	C0006142
Disease	lung carcinoma	UBR2 HLA-DMB TMEM237 NOX3 WDR76 TEFM FASN	2.12e-03	482	109	7	EFO_0001071
Disease	skin pigmentation	FANCA PROZ HERC2	2.15e-03	69	109	3	EFO_0003784
Disease	anorectal malformation	TRPM2 CSMD2	2.22e-03	19	109	2	MONDO_0019938
Disease	skin sensitivity to sun	FANCA HERC2	2.22e-03	19	109	2	EFO_0004795
Disease	platelet-to-lymphocyte ratio	ABCC4 SLC4A1 BTN2A3P YDJC PLEC NUP160	2.33e-03	363	109	6	EFO_0008446
Disease	myeloid white cell count	UBR2 ACAP1 PIEZO1 FAM83E PKD1 YDJC HFM1 FAM53B NUP160 PLCE1	2.49e-03	937	109	10	EFO_0007988
Disease	glioblastoma (is_implicated_in)	PTPRB PIK3CB	3.54e-03	24	109	2	DOID:3068 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLWHATRSTRETLLN	UMODL1	656	Q5DID0
LSLAGWRRTFLHAAN	BTN2A3P	286	Q96KV6
RQAGFRAWSSHLISL	DCANP1	196	Q8TF63
VASLHSFQRRWITRA	ACTL10	216	Q5JWF8
TTGTRHHTWLIFVFL	AGBL3	726	Q8NEM8
VSSISVEHGRWRLIF	CSMD2	2596	Q7Z408
AHTTTARWSLTLLPR	LINC00269	66	Q8N2A0
HLTFWSLLELRRVFT	SLC4A1	101	P02730
ISVHWRSLSSRGFSQ	ALPK2	1321	Q86TB3
IFRWLAISFASAHLT	AEBP1	811	Q8IUX7
TIYSLTSAGRWTHRA	CYP4A11	241	Q02928
GVHFSKVRSLTLDSW	ACAP1	451	Q15027
VLRSISRFHWRSQHT	ACADM	11	P11310
VTTRGWTASHIAAIR	ANKRD42	61	Q8N9B4
AARLLFSTVEWARHA	NR2F6	206	P10588
ADGQLLHYRTSSLRW	ARHGAP39	191	Q9C0H5
LLFNRSREHGTLWSL	LTN1	1076	O94822
RFIWKRGSDTLSHSQ	MDGA1	166	Q8NFP4
ERHWRIFSLSGTLET	POLDIP2	281	Q9Y2S7
RTHRSVTWISAGLAE	FBXO22	61	Q8NEZ5
LSLLVSSGWRTISFH	MAB21L4	186	Q08AI8
FWCSHISRLVRSLSL	ESPNL	591	Q6ZVH7
ASSHSVSIQWRILGS	PTPRB	36	P23467
SESLWHIQISRSRFL	KIAA0100	151	Q14667
SGLVHIWSLQTRRAV	GNB1L	46	Q9BYB4
GLRWVRFTLGRSSSL	LRP12	736	Q9Y561
LVSHAVTTLWASVGR	MSS51	206	Q4VC12
HRSWCTLGFVRSIAL	HERC2	2021	O95714
AGSLLTSRWVITAAH	PRSS22	76	Q9GZN4
FHLWKARSTLSRLLS	DCAF12L2	286	Q5VW00
GWRATRLFHDSAVTS	DCAF4L1	261	Q3SXM0
GSVLDWSSHFARTTI	TMEM63C	161	Q9P1W3
FARHVSNTRAWTALL	FAM53B	326	Q14153
TLFIQRGRHETTWTV	RHOT1	256	Q8IXI2
WEASSLRSSRHSGLS	PTGER1	386	P34995
LSSGVSEIRHTADRW	HSPB1	81	P04792
LEGDVRWRRLFSSTH	FGF22	36	Q9HCT0
HRALFRLSPTASRSW	GDF15	121	Q99988
RVGLGESSVWTSHRT	PRTG	596	Q2VWP7
GGSLLSRRWVLSAAH	PRSS41	81	Q7RTY9
TAKIFRHGSRITRWL	HFM1	881	A2PYH4
RHGSRITRWLSDFVA	HFM1	886	A2PYH4
FSHLSSSLQGLWTIR	ABCC4	901	O15439
RGFSWQSVLLTHQRT	PRDM9	671	Q9NQV7
SWLSNSFREILTHRS	PLA2G4E	636	Q3MJ16
SWRSGGFRNLHTIVL	FBXO38	286	Q6PIJ6
SSIVGHTLWVRFISD	CUBN	1821	O60494
RALSWSYDILTGHIR	FRMD3	506	A2A2Y4
IIFSLGVISWRRAGH	HLA-DMB	231	P28068
LVISERTHRSFRVSW	COL12A1	1391	Q99715
GLHVLRTWVSSAAQT	GCDH	16	Q92947
AALSLWTHRTFREVL	FANCA	906	O15360
SQWTVRSIHDLRFIS	CNTF	166	P26441
TIYSLTSAGRWTHRA	CYP4A22	241	Q5TCH4
GRRLSIHVVTWNVAS	INPP5K	11	Q9BT40
AHRDSSLKRLTRWGS	DEF6	576	Q9H4E7
HWLLELVTTRGSTGR	IDUA	91	P35475
HRGWLLLQVSSRVFT	FCGR1A	101	P12314
RSSSWRILGSKQSEH	IRAG2	401	Q12912
SRWLRVTVAGGVHIS	FASN	1081	P49327
VEHRTVAGVLSSTFW	SLC22A7	226	Q9Y694
SSHFRWSALQVSVGL	PKD1	2996	P98161
RIHLTTERGFWTVSL	RFPL1	206	O75677
LSFIIIDWASGTSRH	SLC38A3	486	Q99624
WTLFHRANISTGLSL	TMEM217B	51	A0A494BZU4
WSDARLHRGLVTLLT	FAM83E	256	Q2M2I3
TLFIQRGRHETTWTI	RHOT2	256	Q8IXI1
TLAHAVELFGGRRWS	PLCE1	1041	Q9P212
TWGRLVTRHFSHAAR	MRM1	11	Q6IN84
SLWRDFHKTSILARS	PTCHD4	221	Q6ZW05
VVTREHRGSWFLTGV	PROZ	356	P22891
ISIVFGTRRIAWAHL	TEFM	171	Q96QE5
LESHSRGILSVSWSQ	SEC31B	256	Q9NQW1
QLRTGDIILHSWSSF	PIK3CB	451	P42338
SGKLFSVTRNRFIHW	NUP160	91	Q12769
SVTRNRFIHWKTSGD	NUP160	96	Q12769
HYTRVILGSTLAWAR	NOX3	41	Q9HBY0
LERERLTSGTTWHTA	SARDH	96	Q9UL12
HLGTSSRWAVFSILL	SLC39A2	216	Q9NP94
RSILISSRHFWTILV	CMKLR2	236	P46091
DRVHVLVLSSWRSGS	CHST5	61	Q9GZS9
VHVLVLSSWRSGSSF	CHST6	41	Q9GZX3
VHATWRTGSSFLGEL	CHST7	106	Q9NS84
IVIRWVHCFSSSLRG	C10orf67	16	Q8IYJ2
SWTTRDVALTVHRAF	TMEM237	211	Q96Q45
TTTVHWLESRRFSPI	PRPF8	811	Q6P2Q9
RWSKQTDVGITHFRS	PRPF8	1341	Q6P2Q9
LSNSAISRLAHTWER	RAPGEF3	761	O95398
RKSFSRSSSLIQHWR	ZNF132	521	P52740
SWAEGTSTRLISGHR	WDR90	1421	Q96KV7
GLGFLTSSFRRHSWS	RHD	61	Q02161
LHGLSLSRRSTSWSA	PIK3R5	21	Q8WYR1
WLSHLEERLASGFRS	SAMD4B	146	Q5PRF9
LHWIVRTLRASGFSS	TRPM2	1191	O94759
HSFRLARLSSWRVHA	TMPRSS5	261	Q9H3S3
ARLSSWRVHAGLVSH	TMPRSS5	266	Q9H3S3
LTLWHLRSSTPTTIF	THOC6	241	Q86W42
SRHGLRWTDAFVGLS	YDJC	196	A8MPS7
TSSWRDGRLFNAIIH	PLEC	321	Q15149
SASIDQRLTFWRLGH	WDR6	1061	Q9NNW5
FGWHRSETLGALASV	SLC30A3	136	Q99726
FRWASGLSRHVRVHS	ZNF225	381	Q9UK10
AFVWSSTLTRHKRLH	ZNF726	321	A6NNF4
VFNWFSTLTRHRRIH	ZNF430	241	Q9H8G1
LWSSTLTRHKRIHTG	ZNF91	276	Q05481
FIWSSTLTRHKRIHT	ZNF91	471	Q05481
FLWSSTLRRHKRIHT	ZNF91	611	Q05481
TTIRHNTFTGRWLTR	WDR76	536	Q9H967
FIWFSTLTRHRRVHT	ZNF493	91	Q6ZR52
AFRQSSSLTLHRRWH	ZNF74	256	Q16587
GKTFTWSSTFREHVR	ZNF57	426	Q68EA5
RWHTLVLAVSAGVFS	TSPEAR	156	Q8WU66
SRWETLSRHIGVTRL	PIEZO1	96	Q92508
LFRVETHRDLSSWTR	SNTB2	416	Q13425
THRDLSSWTRILVQG	SNTB2	421	Q13425
WRTAAFVQRHRTGLL	TMEM177	6	Q53S58
LRSLTRFAAAHWTVA	UBR2	1366	Q8IWV8
LHTLRWSSRLRISSY	UBR4	1036	Q5T4S7
LISLAAHLSQWTRGR	SIT1	56	Q9Y3P8
FAQSSGLVRHWRIHT	ZKSCAN8	331	Q15776
TGWSLCRSLIHLFRT	TMEM39B	171	Q9GZU3