Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	IQSEC2 MCF2L2 OBSCN ARHGEF38 LAMTOR3 HERC2 RAPGEF2 SOS1 SOS2	1.02e-05	231	119	9	GO:0005085
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RGPD2 IQSEC2 MCF2L2 OBSCN ARHGEF38 SRGAP2 LAMTOR3 HERC2 RAPGEF2 SOS1 SOS2	2.27e-04	507	119	11	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	RGPD2 IQSEC2 MCF2L2 OBSCN ARHGEF38 SRGAP2 LAMTOR3 HERC2 RAPGEF2 SOS1 SOS2	2.27e-04	507	119	11	GO:0030695
GeneOntologyMolecularFunction	histone modifying activity	KDM5C ASH1L DYRK1A KDM5D NSD3 EHMT1 TAF1	4.49e-04	229	119	7	GO:0140993
GeneOntologyMolecularFunction	histone H3K27 methyltransferase activity	NSD3 EHMT1	5.20e-04	6	119	2	GO:0046976
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5C KDM5D	5.20e-04	6	119	2	GO:0034647
GeneOntologyBiologicalProcess	circulatory system development	NDNF ETS1 DYRK1A IRX3 ITGA4 PTCH1 NEB HIF1AN RXRA EDN1 MEIS1 IRX4 PIK3CG CSPG4 AGTR1 LRP1 FGF2 PLG RAPGEF2 NAXE DNAH11 SOS1	8.63e-06	1442	112	22	GO:0072359
GeneOntologyBiologicalProcess	tube morphogenesis	NDNF ETS1 IRX3 IRX1 PTCH1 HIF1AN RXRA EDN1 MEIS1 BRD2 PIK3CG CSPG4 AGTR1 LRP1 FGF2 PLG RAPGEF2 NAXE SOS1	9.55e-06	1125	112	19	GO:0035239
GeneOntologyBiologicalProcess	regulation of cholesterol efflux	PTCH1 RXRA ABCA5 LRP1 NAXE	1.32e-05	56	112	5	GO:0010874
GeneOntologyBiologicalProcess	kidney morphogenesis	GCNT3 IRX3 IRX1 PTCH1 AGTR1 FGF2	3.19e-05	111	112	6	GO:0060993
GeneOntologyBiologicalProcess	blood vessel morphogenesis	NDNF ETS1 HIF1AN RXRA EDN1 MEIS1 PIK3CG CSPG4 AGTR1 LRP1 FGF2 PLG RAPGEF2 NAXE SOS1	3.57e-05	817	112	15	GO:0048514
GeneOntologyBiologicalProcess	regulation of lipid transport	PTCH1 RXRA EDN1 ABCA5 AGTR1 LRP1 NAXE	5.55e-05	179	112	7	GO:0032368
GeneOntologyBiologicalProcess	heart development	DYRK1A IRX3 ITGA4 PTCH1 NEB RXRA EDN1 MEIS1 IRX4 AGTR1 LRP1 FGF2 DNAH11 SOS1	6.15e-05	757	112	14	GO:0007507
GeneOntologyBiologicalProcess	cholesterol efflux	PTCH1 RXRA ABCA5 LRP1 NAXE	6.25e-05	77	112	5	GO:0033344
GeneOntologyBiologicalProcess	positive regulation of sterol transport	PTCH1 RXRA ABCA5 LRP1	6.48e-05	40	112	4	GO:0032373
GeneOntologyBiologicalProcess	positive regulation of cholesterol transport	PTCH1 RXRA ABCA5 LRP1	6.48e-05	40	112	4	GO:0032376
GeneOntologyBiologicalProcess	nephron epithelium development	IRX3 IRX1 PTCH1 EDN1 AGTR1 FGF2	7.10e-05	128	112	6	GO:0072009
GeneOntologyBiologicalProcess	regulation of cholesterol transport	PTCH1 RXRA ABCA5 LRP1 NAXE	8.94e-05	83	112	5	GO:0032374
GeneOntologyBiologicalProcess	regulation of sterol transport	PTCH1 RXRA ABCA5 LRP1 NAXE	8.94e-05	83	112	5	GO:0032371
GeneOntologyBiologicalProcess	cholesterol transport	PTCH1 SYT7 RXRA ABCA5 LRP1 NAXE	9.15e-05	134	112	6	GO:0030301
GeneOntologyBiologicalProcess	chromatin organization	ARID4A KDM5C SMCHD1 ASH1L DYRK1A INO80 KDM5D NSMCE3 NSD3 BRD2 EHMT1 CBX7 SLFN11 TAF1 TASOR	1.01e-04	896	112	15	GO:0006325
GeneOntologyBiologicalProcess	nephron tubule morphogenesis	IRX3 IRX1 PTCH1 AGTR1 FGF2	1.12e-04	87	112	5	GO:0072078
GeneOntologyBiologicalProcess	sterol transport	PTCH1 SYT7 RXRA ABCA5 LRP1 NAXE	1.12e-04	139	112	6	GO:0015918
GeneOntologyBiologicalProcess	nephron epithelium morphogenesis	IRX3 IRX1 PTCH1 AGTR1 FGF2	1.25e-04	89	112	5	GO:0072088
GeneOntologyBiologicalProcess	nephron morphogenesis	IRX3 IRX1 PTCH1 AGTR1 FGF2	1.38e-04	91	112	5	GO:0072028
GeneOntologyBiologicalProcess	blood vessel development	NDNF ETS1 HIF1AN RXRA EDN1 MEIS1 PIK3CG CSPG4 AGTR1 LRP1 FGF2 PLG RAPGEF2 NAXE SOS1	1.50e-04	929	112	15	GO:0001568
GeneOntologyBiologicalProcess	renal tubule morphogenesis	IRX3 IRX1 PTCH1 AGTR1 FGF2	1.53e-04	93	112	5	GO:0061333
GeneOntologyBiologicalProcess	regulation of lipid localization	PTCH1 RXRA EDN1 ABCA5 AGTR1 LRP1 NAXE	1.74e-04	215	112	7	GO:1905952
GeneOntologyBiologicalProcess	specification of loop of Henle identity	IRX3 IRX1	1.74e-04	4	112	2	GO:0072086
GeneOntologyBiologicalProcess	tube development	NDNF ETS1 IRX3 IRX1 PTCH1 HIF1AN RXRA EDN1 MEIS1 BRD2 PIK3CG CSPG4 AGTR1 LRP1 FGF2 PLG RAPGEF2 NAXE SOS1	1.87e-04	1402	112	19	GO:0035295
GeneOntologyBiologicalProcess	chromatin remodeling	ARID4A KDM5C SMCHD1 ASH1L DYRK1A INO80 KDM5D NSD3 BRD2 EHMT1 SLFN11 TAF1 TASOR	1.93e-04	741	112	13	GO:0006338
GeneOntologyBiologicalProcess	positive regulation of lipid transport	PTCH1 RXRA EDN1 ABCA5 LRP1	2.36e-04	102	112	5	GO:0032370
GeneOntologyBiologicalProcess	vasculature development	NDNF ETS1 HIF1AN RXRA EDN1 MEIS1 PIK3CG CSPG4 AGTR1 LRP1 FGF2 PLG RAPGEF2 NAXE SOS1	2.37e-04	969	112	15	GO:0001944
GeneOntologyBiologicalProcess	embryo development	DSC3 IRX3 IRX1 INO80 ITGA4 PTCH1 RXRA EDN1 MEIS1 AGBL4 MYO3A BRD2 RBM19 EHMT1 FGF2 UBR3 PLG TASOR SOS1	2.56e-04	1437	112	19	GO:0009790
GeneOntologyBiologicalProcess	kidney epithelium development	IRX3 IRX1 PTCH1 EDN1 AGTR1 FGF2	2.58e-04	162	112	6	GO:0072073
GeneOntologyBiologicalProcess	specification of nephron tubule identity	IRX3 IRX1	2.89e-04	5	112	2	GO:0072081
GeneOntologyBiologicalProcess	proximal/distal pattern formation involved in nephron development	IRX3 IRX1	2.89e-04	5	112	2	GO:0072047
GeneOntologyBiologicalProcess	protein-DNA complex organization	ARID4A KDM5C SMCHD1 ASH1L DYRK1A INO80 KDM5D NSMCE3 NSD3 BRD2 EHMT1 CBX7 SLFN11 TAF1 TASOR	3.29e-04	999	112	15	GO:0071824
GeneOntologyBiologicalProcess	nephron tubule development	IRX3 IRX1 PTCH1 AGTR1 FGF2	3.36e-04	110	112	5	GO:0072080
GeneOntologyBiologicalProcess	nephron development	IRX3 IRX1 PTCH1 EDN1 AGTR1 FGF2	3.78e-04	174	112	6	GO:0072006
GeneOntologyBiologicalProcess	cardiac muscle cell differentiation	DYRK1A IRX3 NEB RXRA EDN1 MEIS1	4.14e-04	177	112	6	GO:0055007
GeneOntologyBiologicalProcess	positive regulation of cholesterol efflux	PTCH1 RXRA LRP1	4.15e-04	27	112	3	GO:0010875
GeneOntologyBiologicalProcess	renal tubule development	IRX3 IRX1 PTCH1 AGTR1 FGF2	4.29e-04	116	112	5	GO:0061326
GeneOntologyBiologicalProcess	pericardium development	ITGA4 RXRA SOS1	4.62e-04	28	112	3	GO:0060039
GeneOntologyBiologicalProcess	angiogenesis involved in coronary vascular morphogenesis	RXRA FGF2	6.03e-04	7	112	2	GO:0060978
GeneOntologyBiologicalProcess	glycosaminoglycan catabolic process	IDS FGF2 FUCA1	6.89e-04	32	112	3	GO:0006027
GeneOntologyBiologicalProcess	positive regulation of lipid localization	PTCH1 RXRA EDN1 ABCA5 LRP1	6.96e-04	129	112	5	GO:1905954
GeneOntologyBiologicalProcess	pattern specification involved in kidney development	IRX3 IRX1	8.01e-04	8	112	2	GO:0061004
GeneOntologyBiologicalProcess	regulation of pro-B cell differentiation	SOS1 SOS2	8.01e-04	8	112	2	GO:2000973
GeneOntologyBiologicalProcess	paracrine signaling	CGAS FGF2	8.01e-04	8	112	2	GO:0038001
GeneOntologyBiologicalProcess	renal system pattern specification	IRX3 IRX1	8.01e-04	8	112	2	GO:0072048
GeneOntologyBiologicalProcess	regulation of renal sodium excretion	EDN1 AGTR1	8.01e-04	8	112	2	GO:0035813
GeneOntologyCellularComponent	multivesicular body lumen	PGA4 PGA5 PGA3	6.19e-06	7	119	3	GO:0097486
GeneOntologyCellularComponent	late endosome lumen	PGA4 PGA5 PGA3	2.87e-05	11	119	3	GO:0031906
MousePheno	abnormal muscle morphology	NDNF SCYL3 OBSCN IDS PTCH1 NEB SYT7 HIF1AN RXRA EDN1 IRX4 BRD2 ABCA5 PIK3CG LTN1 LRP1 DNAJC5 CAVIN1 DNAH11 SOS1	1.58e-05	1106	89	20	MP:0002108
Domain	Homeobox_KN	IRX3 IRX1 MEIS1 IRX4	3.05e-06	17	115	4	PF05920
Domain	Homeobox_KN_domain	IRX3 IRX1 MEIS1 IRX4	3.05e-06	17	115	4	IPR008422
Domain	IRO	IRX3 IRX1 IRX4	4.49e-06	6	115	3	SM00548
Domain	Iroquois_homeo	IRX3 IRX1 IRX4	4.49e-06	6	115	3	IPR003893
Domain	Aspartic_peptidase_N	PGA4 PGA5 PGA3	7.82e-06	7	115	3	IPR012848
Domain	A1_Propeptide	PGA4 PGA5 PGA3	7.82e-06	7	115	3	PF07966
Domain	Aspartic_peptidase_A1	PGA4 PGA5 PGA3	2.64e-05	10	115	3	IPR001461
Domain	PEPTIDASE_A1	PGA4 PGA5 PGA3	2.64e-05	10	115	3	IPR033121
Domain	Asp	PGA4 PGA5 PGA3	2.64e-05	10	115	3	PF00026
Domain	PEPTIDASE_A1	PGA4 PGA5 PGA3	2.64e-05	10	115	3	PS51767
Domain	DH_1	MCF2L2 OBSCN ARHGEF38 SOS1 SOS2	4.29e-05	63	115	5	PS00741
Domain	-	PGA4 PGA5 PGA3	4.80e-05	12	115	3	2.40.70.10
Domain	ASP_PROTEASE	PGA4 PGA5 PGA3	4.80e-05	12	115	3	PS00141
Domain	RhoGEF	MCF2L2 OBSCN ARHGEF38 SOS1 SOS2	6.20e-05	68	115	5	SM00325
Domain	Aspartic_peptidase_AS	PGA4 PGA5 PGA3	6.22e-05	13	115	3	IPR001969
Domain	RhoGEF	MCF2L2 OBSCN ARHGEF38 SOS1 SOS2	7.13e-05	70	115	5	PF00621
Domain	DH_2	MCF2L2 OBSCN ARHGEF38 SOS1 SOS2	7.13e-05	70	115	5	PS50010
Domain	-	MCF2L2 OBSCN ARHGEF38 SOS1 SOS2	7.64e-05	71	115	5	1.20.900.10
Domain	DH-domain	MCF2L2 OBSCN ARHGEF38 SOS1 SOS2	7.64e-05	71	115	5	IPR000219
Domain	-	ARID4A KDM5C KDM5D	9.80e-05	15	115	3	1.10.150.60
Domain	BRIGHT	ARID4A KDM5C KDM5D	9.80e-05	15	115	3	SM00501
Domain	ARID_dom	ARID4A KDM5C KDM5D	9.80e-05	15	115	3	IPR001606
Domain	ARID	ARID4A KDM5C KDM5D	9.80e-05	15	115	3	PS51011
Domain	ARID	ARID4A KDM5C KDM5D	9.80e-05	15	115	3	PF01388
Domain	Peptidase_aspartic_dom	PGA4 PGA5 PGA3	1.45e-04	17	115	3	IPR021109
Domain	DnaJ	DNAJC6 DNAJB13 DNAJA4 DNAJC5	2.15e-04	48	115	4	PF00226
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	2.24e-04	4	115	2	IPR013637
Domain	PLU-1	KDM5C KDM5D	2.24e-04	4	115	2	PF08429
Domain	DNAJ_1	DNAJC6 DNAJB13 DNAJA4 DNAJC5	2.33e-04	49	115	4	PS00636
Domain	DNAJ_2	DNAJC6 DNAJB13 DNAJA4 DNAJC5	2.33e-04	49	115	4	PS50076
Domain	DnaJ	DNAJC6 DNAJB13 DNAJA4 DNAJC5	2.33e-04	49	115	4	SM00271
Domain	-	DNAJC6 DNAJB13 DNAJA4 DNAJC5	2.33e-04	49	115	4	1.10.287.110
Domain	RasGEFN	RAPGEF2 SOS1 SOS2	2.40e-04	20	115	3	SM00229
Domain	DnaJ_domain	DNAJC6 DNAJB13 DNAJA4 DNAJC5	2.73e-04	51	115	4	IPR001623
Domain	RasGEF_N	RAPGEF2 SOS1 SOS2	2.79e-04	21	115	3	PF00618
Domain	Ras-like_Gua-exchang_fac_N	RAPGEF2 SOS1 SOS2	3.22e-04	22	115	3	IPR000651
Domain	RASGEF_NTER	RAPGEF2 SOS1 SOS2	3.22e-04	22	115	3	PS50212
Domain	AWS	ASH1L NSD3	3.71e-04	5	115	2	SM00570
Domain	AWS	ASH1L NSD3	3.71e-04	5	115	2	PS51215
Domain	AWS_dom	ASH1L NSD3	3.71e-04	5	115	2	IPR006560
Domain	zf-C5HC2	KDM5C KDM5D	3.71e-04	5	115	2	PF02928
Domain	Znf_C5HC2	KDM5C KDM5D	3.71e-04	5	115	2	IPR004198
Domain	DnaJ_domain_CS	DNAJB13 DNAJA4 DNAJC5	5.97e-04	27	115	3	IPR018253
Domain	Zinc_finger_PHD-type_CS	KDM5C ASH1L KDM5D NSD3	6.91e-04	65	115	4	IPR019786
Domain	RASGEF_CAT	RAPGEF2 SOS1 SOS2	7.39e-04	29	115	3	PS50009
Domain	AlbA_2	SLFN14 SLFN11	7.74e-04	7	115	2	PF04326
Domain	Schlafen	SLFN14 SLFN11	7.74e-04	7	115	2	IPR029684
Domain	Schlafen_AAA_dom	SLFN14 SLFN11	7.74e-04	7	115	2	IPR007421
Domain	RasGEF	RAPGEF2 SOS1 SOS2	8.18e-04	30	115	3	PF00617
Domain	-	RAPGEF2 SOS1 SOS2	8.18e-04	30	115	3	1.10.840.10
Domain	RASGEF_cat_dom	RAPGEF2 SOS1 SOS2	8.18e-04	30	115	3	IPR001895
Domain	RasGEF	RAPGEF2 SOS1 SOS2	8.18e-04	30	115	3	SM00147
Domain	Ras_GEF_dom	RAPGEF2 SOS1 SOS2	8.18e-04	30	115	3	IPR023578
Domain	JMJC	KDM5C KDM5D HIF1AN	9.90e-04	32	115	3	PS51184
Domain	JmjC_dom	KDM5C KDM5D HIF1AN	9.90e-04	32	115	3	IPR003347
Domain	JmjC	KDM5C KDM5D HIF1AN	1.08e-03	33	115	3	SM00558
Domain	PHD	KDM5C ASH1L KDM5D NSD3	1.18e-03	75	115	4	PF00628
Domain	DnaJ_C	DNAJB13 DNAJA4	1.32e-03	9	115	2	IPR002939
Domain	DnaJ_C	DNAJB13 DNAJA4	1.32e-03	9	115	2	PF01556
Domain	HSP40/DnaJ_pept-bd	DNAJB13 DNAJA4	1.32e-03	9	115	2	IPR008971
Domain	Znf_PHD-finger	KDM5C ASH1L KDM5D NSD3	1.44e-03	79	115	4	IPR019787
Domain	BROMODOMAIN_1	ASH1L BRD2 TAF1	1.52e-03	37	115	3	PS00633
Domain	JmjN	KDM5C KDM5D	1.64e-03	10	115	2	SM00545
Domain	JmjN	KDM5C KDM5D	1.64e-03	10	115	2	PF02375
Domain	HAT	PDCD11 PRPF39	1.64e-03	10	115	2	SM00386
Domain	JMJN	KDM5C KDM5D	1.64e-03	10	115	2	PS51183
Domain	JmjN	KDM5C KDM5D	1.64e-03	10	115	2	IPR003349
Domain	HAT	PDCD11 PRPF39	1.64e-03	10	115	2	IPR003107
Domain	Bromodomain	ASH1L BRD2 TAF1	1.64e-03	38	115	3	PF00439
Domain	GDS_CDC24_CS	OBSCN SOS1 SOS2	1.77e-03	39	115	3	IPR001331
Domain	SET	ASH1L NSD3 EHMT1	2.04e-03	41	115	3	PF00856
Domain	BROMODOMAIN_2	ASH1L BRD2 TAF1	2.04e-03	41	115	3	PS50014
Domain	Bromodomain	ASH1L BRD2 TAF1	2.19e-03	42	115	3	IPR001487
Domain	BROMO	ASH1L BRD2 TAF1	2.19e-03	42	115	3	SM00297
Domain	-	ASH1L BRD2 TAF1	2.19e-03	42	115	3	1.20.920.10
Domain	PHD	KDM5C ASH1L KDM5D NSD3	2.23e-03	89	115	4	SM00249
Domain	Znf_PHD	KDM5C ASH1L KDM5D NSD3	2.41e-03	91	115	4	IPR001965
Domain	ZF_PHD_2	KDM5C ASH1L KDM5D NSD3	2.82e-03	95	115	4	PS50016
Domain	SET	ASH1L NSD3 EHMT1	2.85e-03	46	115	3	SM00317
Domain	ZF_PHD_1	KDM5C ASH1L KDM5D NSD3	2.93e-03	96	115	4	PS01359
Domain	Ras_G-nucl-exch_fac_CS	SOS1 SOS2	3.26e-03	14	115	2	IPR019804
Domain	SET_dom	ASH1L NSD3 EHMT1	3.61e-03	50	115	3	IPR001214
Domain	SET	ASH1L NSD3 EHMT1	3.61e-03	50	115	3	PS50280
Domain	Post-SET_dom	ASH1L NSD3	4.26e-03	16	115	2	IPR003616
Domain	PostSET	ASH1L NSD3	4.26e-03	16	115	2	SM00508
Domain	POST_SET	ASH1L NSD3	4.26e-03	16	115	2	PS50868
Pubmed	The epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. EUROGAST Study Group.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	7926498
Pubmed	Crystal structure of human pepsinogen A.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	9561228
Pubmed	The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	21455714
Pubmed	Serum pepsinogen level, atrophic gastritis and the risk of incident pancreatic cancer--a prospective cohort study.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	19800305
Pubmed	Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	24170207
Pubmed	Relationships between the human pepsinogen DNA and protein polymorphisms.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	3014868
Pubmed	The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	2799289
Pubmed	CRYSTALLINE PEPSIN : I. ISOLATION AND TESTS OF PURITY.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	19872561
Pubmed	Human pepsinogen A (PGA): an informative gene complex located at 11q13.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	1968039
Pubmed	Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	8053437
Pubmed	Family and population studies on the human pepsinogen A multigene family.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	2566575
Pubmed	Immunoblot technique to visualise serum pepsinogen A isozymogen patterns.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	2229438
Pubmed	Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	25314140
Pubmed	Validation of the pepsinogen test method for gastric cancer screening using a follow-up study.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	19890696
Pubmed	Diagnostic value of serum pepsinogen C in patients with raised serum concentrations of pepsinogen A.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	8244094
Pubmed	Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	21407214
Pubmed	Isolation of an activation intermediate and determination of the amino acid sequence of the activation segment of human pepsinogen A.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	6774973
Pubmed	Primary structure of human pepsinogen gene.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	6300126
Pubmed	Pepsinogen I/II ratio is related to glucose, triacylglycerol, and uric acid levels.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	22304859
Pubmed	Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	24004680
Pubmed	Effect of enprostil on serum gastrin and pepsinogen A and C levels in patients on long-term treatment with omeprazole.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	8038355
Pubmed	Human pepsinogen A isozymogen patterns in serum and gastric mucosa.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	2227273
Pubmed	Identification of a high risk gastric cancer group using serum pepsinogen after successful eradication of Helicobacter pylori.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	23034090
Pubmed	A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	24125879
Pubmed	Effects of omeprazole and lansoprazole on fasting and postprandial serum gastrin and serum pepsinogen A and C.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	8751234
Pubmed	Enzyme-linked immunosorbent assay and radioimmunoassay of serum pepsinogen A.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	3554488
Pubmed	Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case-control study.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	23521833
Pubmed	Close linkage of human chromosomal pepsinogen A genes.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	3017318
Pubmed	Serum pepsinogen test for early detection of gastric cancer in a European country.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	21989121
Pubmed	Serum antibodies to H+,K+-ATPase, serum pepsinogen A and Helicobacter pylori in relation to gastric mucosa morphology in patients with low or low-normal concentrations of serum cobalamins.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	9855083
Pubmed	Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	9797498
Pubmed	The glomerular sieving of pepsinogen A and C in man.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	2478370
Pubmed	Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	3815274
Pubmed	Pepsinogens: physiology, pharmacology pathophysiology and exercise.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	10675278
Pubmed	Pepsinogen A polymorphism in gastric mucosa and urine, with special reference to patients with gastric cancer.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	3780036
Pubmed	Identification of a Glu greater than Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	2901984
Pubmed	Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	3839486
Pubmed	Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	3467902
Pubmed	The pepsinogens of human gastric mucosa.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	4586732
Pubmed	Genomic structure and evolution of the human pepsinogen A multigene family.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	2892778
Pubmed	The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	24383519
Pubmed	Gene structures of pepsinogens A and C.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	1455184
Pubmed	Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	2831884
Pubmed	Localization of pepsinogen (A and C) and cellular differentiation of pepsinogen-synthesizing cells in the human gastric mucosa.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	2032552
Pubmed	Analysis of the promoter of a human pepsinogen A gene.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	1812762
Pubmed	O6-methylguanine in blood leucocyte DNA: an association with the geographic prevalence of gastric cancer and with low levels of serum pepsinogen A, a marker of severe chronic atrophic gastritis. The EUROGAST Study Group.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	7923573
Pubmed	Fast detection of phosphorylation of human pepsinogen A, human pepsinogen C and swine pepsinogen using a combination of reversed-phase high-performance liquid chromatography and capillary zone electrophoresis for peptide mapping.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	9061458
Pubmed	Ratio between serum IL-8 and pepsinogen A/C: a marker for atrophic body gastritis.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	12588289
Pubmed	Gastric cancer detection using gastric juice pepsinogen and melanoma-associated gene RNA.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	23897256
Pubmed	An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	11566730
Pubmed	The effect of acute and chronic protein loading on urinary pepsinogen A excretion.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	1956484
Pubmed	Transcription regulation of human and porcine pepsinogen A.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	8540382
Pubmed	Exploratory findings of audiometry in adult patients with otitis media with high pepsinogen concentrations: a preliminary study.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	22992016
Pubmed	The role of serum pepsinogen in the detection of gastric cancer.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	20981206
Pubmed	Gastric chief cell-specific transcription of the pepsinogen A gene.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	8504820
Pubmed	Detection of pepsinogen in the neonatal lung and stomach by immunohistochemistry.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	21970995
Pubmed	Serum pepsinogens in gastric cancer screening.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	20428942
Pubmed	The relationship of Helicobacter pylori colonization, the serum pepsinogen A level, and gastric resection.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	9525001
Pubmed	Evaluation of pepsinogen A and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	7886402
Pubmed	Serum pepsinogen and gastric cancer screening.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	17379991
Pubmed	Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14-year follow up result in a rural Chinese community.	PGA4 PGA5 PGA3	4.21e-08	3	122	3	21547904
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	KDM5C ASH1L INO80 SQOR SYT7 SAP30 NSD3 BRD2 LTN1 LRP1 EHMT1 MMS19 CAVIN1 SLFN11 TAF1 RAPGEF2 IQCM SOS1	7.32e-08	1116	122	18	31753913
Pubmed	Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes.	PGA4 PGA5 PGA3	1.68e-07	4	122	3	23047493
Pubmed	Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development.	PGA4 PGA5 PGA3	1.68e-07	4	122	3	11915945
Pubmed	Pepsinogen A and C serum levels in relation to acute NSAID-associated mucosal lesions in healthy volunteers.	PGA4 PGA5 PGA3	1.68e-07	4	122	3	8322031
Pubmed	Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression.	PGA4 PGA5 PGA3	1.68e-07	4	122	3	17136346
Pubmed	Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.	PGA4 PGA5 PGA3	1.68e-07	4	122	3	12698190
Pubmed	Accuracy and cut-off values of pepsinogens I, II and gastrin 17 for diagnosis of gastric fundic atrophy: influence of gastritis.	PGA4 PGA5 PGA3	4.19e-07	5	122	3	22066020
Pubmed	Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling.	PGA4 PTCH1 PGA5 PGA3	4.25e-07	18	122	4	36057966
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	IQSEC2 MCF2L2 ASH1L DYRK1A PSMD2 SRGAP2 ZNF302 IDS BRD2 TCERG1 SBNO1 AHCY LRP1 TAF1 HERC2 RAPGEF2 SOS1 SOS2	5.78e-07	1285	122	18	35914814
Pubmed	Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos.	IRX3 IRX1 IRX4	8.36e-07	6	122	3	20408909
Pubmed	Organization of mouse Iroquois homeobox genes in two clusters suggests a conserved regulation and function in vertebrate development.	IRX3 IRX1 IRX4	8.36e-07	6	122	3	11042145
Pubmed	Iroquois homeobox 3 regulates odontoblast proliferation and differentiation mediated by Wnt5a expression.	IRX3 IRX1 IRX4	8.36e-07	6	122	3	36773339
Pubmed	Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast.	IRX3 IRX1 IRX4	8.36e-07	6	122	3	10370142
Pubmed	Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses.	PIK3CG SOS1 SOS2	1.46e-06	7	122	3	30720883
Pubmed	The prepattern transcription factor Irx3 directs nephron segment identity.	IRX3 IRX1 IRX4	1.46e-06	7	122	3	17875669
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	OBSCN DYRK1A SRGAP2 INO80 PTCH1 SAP30 NSD3 PRR12 POMGNT2 BRD2 RBM19 CSPG4 EHMT1 PDCD11 HERC2 TOP3A	1.70e-06	1105	122	16	35748872
Pubmed	New nomenclature for chromatin-modifying enzymes.	KDM5C ASH1L KDM5D EHMT1 TAF1	1.77e-06	57	122	5	18022353
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ARID4A KDM5C ETS1 DYRK1A HIF1AN RXRA MEIS1 SAP30 POMGNT2 TCERG1 AHCY LRP1 MMS19 PRPF39	2.00e-06	857	122	14	25609649
Pubmed	Sensitive nonradioactive detection of mRNA in tissue sections: novel application of the whole-mount in situ hybridization protocol.	IRX3 IRX1 IRX4	2.33e-06	8	122	3	11118473
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	SMCHD1 ASH1L MRPL28 INO80 NSD3 BRD2 TCERG1 CAVIN1 TAF1 HERC2 ZNF512	3.00e-06	533	122	11	30554943
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	KDM5C TCERG1 CEBPZ RBM19 NUP210 LTN1 SLFN11 HERC2	3.03e-06	250	122	8	33536335
Pubmed	The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice.	IRX3 IRX1 IRX4	3.48e-06	9	122	3	14585979
Pubmed	Gene and cluster-specific expression of the Iroquois family members during mouse development.	IRX3 IRX1 IRX4	3.48e-06	9	122	3	11520674
Pubmed	Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart.	IRX3 IRX1 IRX4	6.81e-06	11	122	3	10926765
Pubmed	Multiple roles of epithelial heparan sulfate in stomach morphogenesis.	PGA4 PTCH1 PGA5 PGA3	6.94e-06	35	122	4	29700203
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DSC3 SMCHD1 CGAS PSMD2 MRPL28 ITGA4 SQOR NSD3 TCERG1 CEBPZ RBM19 SVIL NUP210 AHCY PDCD11 CAVIN1	8.68e-06	1257	122	16	36526897
Pubmed	Human transcription factor protein interaction networks.	ARID4A SMCHD1 ETS1 PSMD2 MRPL28 INO80 RXRA YTHDF1 PRR12 BRD2 TCERG1 SVIL EHMT1 PDCD11 TAF1 HERC2 ZNF512	1.07e-05	1429	122	17	35140242
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KDM5C ASH1L KDM5D	1.17e-05	13	122	3	24619213
Pubmed	X-linked dystonia parkinsonism syndrome (XDP, lubag): disease-specific sequence change DSC3 in TAF1/DYT3 affects genes in vesicular transport and dopamine metabolism.	DSC3 TAF1	1.22e-05	2	122	2	23184149
Pubmed	Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family.	PGA4 PGA5	1.22e-05	2	122	2	2714789
Pubmed	A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion.	ITGA4 CSPG4	1.22e-05	2	122	2	9488735
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	1.22e-05	2	122	2	10441747
Pubmed	Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE.	F8 LRP1	1.22e-05	2	122	2	27794518
Pubmed	A common polymorphism decreases LRP1 mRNA stability and is associated with increased plasma factor VIII levels.	F8 LRP1	1.22e-05	2	122	2	28431990
Pubmed	Proteolytic cleavage of factor VIII heavy chain is required to expose the binding-site for low-density lipoprotein receptor-related protein within the A2 domain.	F8 LRP1	1.22e-05	2	122	2	16839343
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	1.22e-05	2	122	2	16416087
Pubmed	A homologue of the Drosophila Son of sevenless gene maps to mouse chromosome 17.	SOS1 SOS2	1.22e-05	2	122	2	8307589
Pubmed	Activation of human pepsinogens.	PGA4 PGA5	1.22e-05	2	122	2	3197840
Pubmed	Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.	F8 LRP1	1.22e-05	2	122	2	25903134
Interaction	MAGEA9 interactions	REXO5 ASH1L HIF1AN MEIS1 PDCD11 UBR3 TAF1 HERC2 RAPGEF2	2.84e-06	208	114	9	int:MAGEA9
GeneFamily	TALE class homeoboxes and pseudogenes	IRX3 IRX1 MEIS1 IRX4	4.93e-06	26	80	4	526
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	MCF2L2 OBSCN ARHGEF38 SOS1 SOS2	1.08e-05	66	80	5	722
GeneFamily	AT-rich interaction domain containing	ARID4A KDM5C KDM5D	3.65e-05	15	80	3	418
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJC6 DNAJB13 DNAJA4 DNAJC5	6.47e-05	49	80	4	584
GeneFamily	Schlafen family	SLFN14 SLFN11	4.00e-04	7	80	2	1110
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	ASH1L NSD3 EHMT1	4.52e-04	34	80	3	487
GeneFamily	PHD finger proteins	KDM5C ASH1L KDM5D NSD3	6.80e-04	90	80	4	88
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM5D	5.01e-03	24	80	2	485
Coexpression	FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_DN	PGA4 AADACL3 GLB1L CGAS INO80 KDM5D TTTY10 PGA5 SAP30 NSD3 TCERG1 LRP1 PGA3 PGBD2 SOS2	1.35e-06	746	118	15	M40863
Coexpression	GSE11961_MARGINAL_ZONE_BCELL_VS_GERMINAL_CENTER_BCELL_DAY7_DN	NDNF CGAS RXRA SAP30 PIK3CG LAMTOR3 RAPGEF2 ZNF512	3.57e-06	200	118	8	M9321
Coexpression	GSE42724_NAIVE_VS_MEMORY_BCELL_DN	ARID4A IQSEC2 CGAS ITGA4 FEM1C SAP30 NSD3 YTHDF1	3.57e-06	200	118	8	M9793
Coexpression	GSE17721_LPS_VS_POLYIC_16H_BMDC_DN	OMD KHDC4 EDN1 YTHDF1 BRD2 LRP1 NAXE	3.50e-05	200	118	7	M3819
Disease	Childhood Medulloblastoma	PTCH1 BRD2 PIK3CG EHMT1	2.32e-05	43	114	4	C0278510
Disease	Melanotic medulloblastoma	PTCH1 BRD2 PIK3CG EHMT1	2.32e-05	43	114	4	C1275668
Disease	Medullomyoblastoma	PTCH1 BRD2 PIK3CG EHMT1	2.32e-05	43	114	4	C0205833
Disease	Desmoplastic Medulloblastoma	PTCH1 BRD2 PIK3CG EHMT1	2.32e-05	43	114	4	C0751291
Disease	Adult Medulloblastoma	PTCH1 BRD2 PIK3CG EHMT1	2.32e-05	43	114	4	C0278876
Disease	diabetic retinopathy (biomarker_via_orthology)	EDN1 PIK3CG FGF2 FUCA1	2.79e-05	45	114	4	DOID:8947 (biomarker_via_orthology)
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C DYRK1A KDM5D	3.03e-05	16	114	3	DOID:0050888 (implicated_via_orthology)
Disease	Medulloblastoma	PTCH1 BRD2 PIK3CG EHMT1	4.24e-05	50	114	4	C0025149
Disease	prostate carcinoma in situ (biomarker_via_orthology)	RXRA LRP1	8.83e-05	4	114	2	DOID:8634 (biomarker_via_orthology)
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	8.83e-05	4	114	2	DOID:0060809 (implicated_via_orthology)
Disease	monocyte:lymphocyte ratio	PSMD2 ITGA4	1.47e-04	5	114	2	EFO_0007956
Disease	type 2 diabetes mellitus (is_marker_for)	ETS1 F8 EDN1 FGF2 FUCA1	1.90e-04	136	114	5	DOID:9352 (is_marker_for)
Disease	nephritis (implicated_via_orthology)	ITGA4 AGTR1	6.52e-04	10	114	2	DOID:10952 (implicated_via_orthology)
Disease	hyperhomocysteinemia (implicated_via_orthology)	F8 AHCY	7.95e-04	11	114	2	DOID:9279 (implicated_via_orthology)
Disease	multiple myeloma	CBX7 HERC2 DNAH11 SOS1	9.52e-04	112	114	4	EFO_0001378
Disease	AL amyloidosis	CBX7 DNAH11	9.52e-04	12	114	2	MONDO_0019438
Disease	neovascular inflammatory vitreoretinopathy (is_marker_for)	EDN1 FGF2	9.52e-04	12	114	2	DOID:9719 (is_marker_for)
Disease	myeloid leukemia (is_implicated_in)	NSD3 CBX7	1.12e-03	13	114	2	DOID:8692 (is_implicated_in)
Disease	intermediate coronary syndrome (is_marker_for)	EDN1 AGTR1	1.12e-03	13	114	2	DOID:8805 (is_marker_for)
Disease	diabetic retinopathy (is_marker_for)	EDN1 SERPINA4 FGF2	1.21e-03	54	114	3	DOID:8947 (is_marker_for)
Disease	creatinine measurement	OBSCN ETS1 PSMD2 INO80 NEB SQOR EDN1 MEIS1 CSPG4 SVIL SOS2	1.66e-03	995	114	11	EFO_0004518
Disease	autism spectrum disorder (is_implicated_in)	DYRK1A ITGA4	1.71e-03	16	114	2	DOID:0060041 (is_implicated_in)
Disease	pancreatic ductal carcinoma (is_marker_for)	RXRA CBX7 FGF2	1.72e-03	61	114	3	DOID:3587 (is_marker_for)
Disease	Intellectual Disability	SRD5A3 KDM5C ASH1L PRR12 TRPM3 FUCA1 TAF1	1.79e-03	447	114	7	C3714756
Disease	Global developmental delay	KDM5C PRR12 TRPM3 TAF1	1.80e-03	133	114	4	C0557874
Disease	Astrocytosis	ITGA4 FGF2	1.94e-03	17	114	2	C3887640
Disease	Gliosis	ITGA4 FGF2	1.94e-03	17	114	2	C0017639
Disease	level of Phosphatidylcholine (20:4_0:0) in blood serum	PGA5 SYT7	2.17e-03	18	114	2	OBA_2045110
Disease	Noonan-Like Syndrome With Loose Anagen Hair	SOS1 SOS2	2.42e-03	19	114	2	C3501846
Disease	Noonan syndrome-like disorder with loose anagen hair	SOS1 SOS2	2.42e-03	19	114	2	C1843181
Disease	Cardio-facio-cutaneous syndrome	SOS1 SOS2	2.42e-03	19	114	2	C1275081
Disease	Costello syndrome (disorder)	SOS1 SOS2	2.42e-03	19	114	2	C0587248
Disease	leukemia (implicated_via_orthology)	ASH1L MEIS1	2.42e-03	19	114	2	DOID:1240 (implicated_via_orthology)
Disease	alpha-tocopherol measurement	DYRK1A SOS1	2.69e-03	20	114	2	EFO_0007898
Disease	autism spectrum disorder (implicated_via_orthology)	KDM5C ASH1L DYRK1A KDM5D	2.91e-03	152	114	4	DOID:0060041 (implicated_via_orthology)
Disease	COVID-19 (is_implicated_in)	AGTR1 PLG	2.96e-03	21	114	2	DOID:0080600 (is_implicated_in)
Disease	Deep Vein Thrombosis	F8 PLG	2.96e-03	21	114	2	C0149871
Disease	Venous Thrombosis	F8 PLG	2.96e-03	21	114	2	C0042487
Disease	level of Phosphatidylcholine (18:1_20:4) in blood serum	PGA5 SYT7	2.96e-03	21	114	2	OBA_2045104
Disease	level of Phosphatidylcholine (16:0_20:4) in blood serum	PGA5 SYT7	2.96e-03	21	114	2	OBA_2045076
Disease	intellectual disability (implicated_via_orthology)	KDM5C DYRK1A KDM5D	3.10e-03	75	114	3	DOID:1059 (implicated_via_orthology)
Disease	LEOPARD Syndrome	SOS1 SOS2	3.25e-03	22	114	2	C0175704
Disease	Lung diseases	IRX3 IRX1 DNAH11	3.46e-03	78	114	3	C0024115
Disease	Cleft Palate	PTCH1 EDN1 FGF2	3.85e-03	81	114	3	C0008925
Disease	periodontal measurement	ASH1L IRX1	3.86e-03	24	114	2	EFO_0007780
Disease	Noonan Syndrome	SOS1 SOS2	3.86e-03	24	114	2	C0028326

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLKPGDKPHKYKTSL	ABCA5	901	Q8WWZ7
KKLTPKKDFSPHYVP	ASH1L	2816	Q9NR48
YLPKRHRKVCGNPKS	CCL25	66	O15444
NKPPVLGYKDLNLFK	ARID4A	331	P29374
YKVPPFTFHVKKIRE	CAVIN1	316	Q6NZI2
PLLFYLRKRNKTGKH	CSPG4	2241	Q6UVK1
KKYRHRSLLQPNKFG	C8A	56	P07357
LLKYIPPKAKSHSNL	AGTR1	316	P30556
PGPHKLIQKRYDKLL	ARHGEF38	431	Q9NXL2
IKKPHRYKPGTLALR	H3Y2	36	P0DPK5
LEKPLEKKAGHNYGP	DNAH11	2551	Q96DT5
YRKLALKYHPDKNPD	DNAJA4	26	Q8WW22
GKREYKPPGTRKLHN	DYRK1A	411	Q13627
VLAVGYRKLPKHKFP	AADACL3	146	Q5VUY0
YRKLPKHKFPVPVRD	AADACL3	151	Q5VUY0
QLRLKPFYLVPKHAK	CGAS	351	Q8N884
LHYPIDSLTKKPKGF	RBM19	431	Q9Y4C8
FRKKHQKPKSGKYIP	IQCM	51	A0A1B0GVH7
LQEHRKNPYPTKGEK	IRX4	161	P78413
PFYEQQRHLLGPKKK	INO80	196	Q9ULG1
VKPHYKRKESFFPLT	LTN1	1106	O94822
LKRDKDAIYGHPLFP	MEIS1	71	O00470
FLKKHNLNPARKYFP	PGA5	41	P0DJD9
VLDLHKKPFLAKYFP	NUP210	1001	Q8TEM1
KQTIYRFLKLHPRGK	FEM1C	466	Q96JP0
LPQIKSLHYFKLLPD	LIPN	356	Q5VXI9
HYLGGRFVPPALEKK	NAXE	256	Q8NCW5
PTPKRIEYPLKAHQK	HIF1AN	301	Q9NWT6
HVRYPKLLEGLQGKK	HERC2	696	O95714
GFKPRIHLNKNPEEY	IBTK	646	Q9P2D0
YLKGLSHVLNRLPKP	MMS19	891	Q96T76
KPEHELFLVYGKGRP	LRP1	521	Q07954
HYRIGLNLFNKKPEK	IQSEC2	756	Q5JU85
KDKEYKPHSIPLRQS	KDM5D	186	Q9BY66
QLDHNLPLFKYLKGP	MCF2L2	741	Q86YR7
PNHKPKGTFKDYVRD	ETS1	296	P14921
IKKPHRYKPGTLALR	H3Y1	36	P0DPK2
PLYLLDKKNGFKTQH	FUCA1	191	P04066
KPSPKLGRHVYSRPK	NDNF	271	Q8TB73
YSRRLPKGVKHLKDF	F8	506	P00451
AHFDLYKLLSPKQPL	POMGNT2	201	Q8NAT1
RKLALKYHPDKNPDN	DNAJC5	36	Q9H3Z4
EGIKRPYFHVKPLEK	PRPF39	336	Q86UA1
FLKKHNLNPARKYFP	PGA3	41	P0DJD8
RALAAKIIPYHPKDK	OBSCN	7696	Q5VST9
VKSFLPYLLGPKKDH	SCYL3	306	Q8IZE3
SKFVSYPKHRKAFLP	SRD5A3	301	Q9H8P0
HSKGYIDINPLRKLP	GSTT4	41	A0A1W2PR19
RNGNGLRYKKLHDPK	DSC3	501	Q14574
DKRKKPLPYGSHNIA	FASTKD1	736	Q53R41
LHLTNKKKDPPPYNL	GCNT3	276	O95395
KIFTLLRKYEPHGPL	GLB1L	246	Q6UWU2
PGYPHSRLSKKYVKQ	GIMD1	76	P0DJR0
DKPYRPHFKPLTIKS	DNAJC6	221	O75061
HKYLRLSRKKFPPRG	CBX7	146	O95931
VQRRKEKSPPYKHPL	AGBL4	461	Q5VU57
KRFLYKKLPSVEGLH	LAMTOR3	6	Q9UHA4
KIGFLKPHENKTYLA	ITGA4	636	P13612
INDIIHPKYFKKVPG	DNAJB13	261	P59910
PGHFKDPKRLYCKNG	FGF2	156	P09038
YISHPKPEGLAAAKK	KHDC4	296	Q7Z7F0
HKPHIPFRYPKEFQK	IDS	226	P22304
HDPKLKGKPSRERYV	EDN1	191	P05305
PDKYPVGVHFLPKKL	AHCY	376	P23526
EKHFPAPDRKKLYSL	SBNO1	666	A3KN83
HKYPEQPGRFAKLLL	RXRA	406	P19793
KPKKLRFHPKQLYFS	EHMT1	731	Q9H9B1
LDRFVYRNPKPHKGK	CEBPZ	756	Q03701
FLKKHNLNPARKYFP	PGA4	41	P0DJD7
LNEHRKNPYPTKGEK	IRX3	146	P78415
SSIPEKYFDKLPKLH	OMD	246	Q99983
SDPFVKIYLLPDKKH	SYT7	171	O43581
PYGDQRLKPKHTKLF	TMEM106A	81	Q96A25
YEKIKGLPEGFAHPK	SQOR	151	Q9Y6N5
SPGYPIKVHKFKEAL	SLFN14	376	P0C7P3
PGDAKYGSPKHRLIK	SHD	66	Q96IW2
HLPKLPPKTYKRELS	SOS2	1301	Q07890
LPHFRNGKLYFKPIG	SMCHD1	1791	A6NHR9
GIHPKTPNKFKKYSR	SLBP	166	Q14493
RKFVPKHKSYLTPGL	SLC9C1	1106	Q4G0N8
LKKPAPKSYLIHAGL	SVIL	2096	O95425
YKRHFKLPTRPGLNK	SAP30	161	O75446
AKLFPGSPAIYKLKE	RGPD2	121	P0DJD1
FPHKYKKRRPQDGKG	RNF165	266	Q6ZSG1
SVPKPLKFLRPHYGK	PSMD2	91	Q13200
KLRQFHRPPLKKYSF	TAF1	611	P21675
LNEHRKNPYPTKGEK	IRX1	146	P78414
YKKLELHLPKFSISG	SERPINA4	311	P29622
PGYFNKLEKPRHFKQ	MARCOL	76	A0A1B0GUY1
AEKHYAPFLLKPKAK	PTCH1	736	Q13635
PLSRPVYSKKGLEHK	SLFN11	376	Q7Z7L1
SSKPGKKHRYLRLLP	SLCO6A1	41	Q86UG4
LDFLKSGKRHPPLYQ	PRR12	1286	Q9ULL5
AHGYIPSKFPNKNLK	PLG	216	P00747
HYKKYLAKLRSINPP	SOS1	911	Q07889
HLKQKIPPALFYKET	TASOR	401	Q9UK61
VKLGLPDYHKIIKQP	BRD2	106	P25440
KFLKHLTGPLYFSPK	ALKAL2	96	Q6UX46
YHPVFGKAIIKKYRP	CHST9	301	Q7L1S5
KKQNEYGPPGKLFVH	CLCA4	141	Q14CN2
SKQLHRGKPVRLGYK	PGBD2	281	Q6P3X8
ESLKHPKAYPKLFSS	PIK3CG	581	P48736
PHLPKIGDIKKASRY	RAPGEF2	486	Q9Y4G8
PSKKALYNKHLPEGK	PDCD11	1361	Q14690
GSQPAYPEKLRHKKD	PLEKHA6	576	Q9Y2H5
LGLARKDYPKNRHPG	SPRYD3	276	Q8NCJ5
TRKAKPDGQYHLKPE	REV1	621	Q9UBZ9
HKIVFDPRYLLLNPK	TCERG1	686	O14776
TLYHNLFGPKRPKAL	TRPM3	606	Q9HCF6
ARYFLKHGPKKIAEL	REXO5	376	Q96IC2
KLYFRGLEHPLFPKD	SRGAP2	566	O75044
YLLPVLKPGHFKKNC	TTTY10	46	Q9BZA0
VHYRPHGAKFKINPK	MRPL28	41	Q13084
LEIEKNSRKPPPYKH	NSD3	1061	Q9BZ95
GVYPTKKHLIFGDPK	NSMCE3	206	Q96MG7
HPVYRLKLKFKRGSL	TOP3A	711	Q13472
PPYKKRTSLHPSYKG	UBR3	901	Q6ZT12
FHSPEVPKIKGNRKY	TMEM202	11	A6NGA9
FPQKKHKLYGRKQRP	ZNF512	116	Q96ME7
PVLEKLKAAHSYNPK	YTHDF1	366	Q9BYJ9
EKKLSKAYPFPLSHS	ZNF302	66	Q9NR11
KDKEYKPHSIPLRQS	KDM5C	186	P41229
KLAHYKLPENKPPRY	MYO3A	541	Q8NEV4
KLKHKYTIDPELPQF	NEB	1511	P20929