Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein tag activity	SUMO4 SUMO3 SUMO2	1.28e-05	14	67	3	GO:0031386
GeneOntologyMolecularFunction	molecular tag activity	SUMO4 SUMO3 SUMO2	1.28e-05	14	67	3	GO:0141047
GeneOntologyMolecularFunction	glutathione transmembrane transporter activity	SLC25A40 ABCC5	2.30e-04	7	67	2	GO:0034634
GeneOntologyMolecularFunction	SUMO transferase activity	SUMO4 SUMO3 SUMO2	2.38e-04	36	67	3	GO:0019789
GeneOntologyMolecularFunction	tripeptide transmembrane transporter activity	SLC25A40 ABCC5	3.93e-04	9	67	2	GO:0042937
Domain	SUMO_chordates	SUMO4 SUMO3 SUMO2	4.21e-08	3	66	3	IPR027218
Domain	Sumo	SUMO4 SUMO3 SUMO2	1.68e-07	4	66	3	IPR033950
Domain	Rad60-SLD	SUMO4 SUMO3 SUMO2	4.19e-07	5	66	3	PF11976
Domain	Rad60/SUMO-like_dom	SUMO4 SUMO3 SUMO2	4.19e-07	5	66	3	IPR022617
Domain	UBQ	SUMO4 SUMO3 SUMO2	4.70e-04	43	66	3	SM00213
Domain	ubiquitin	SUMO4 SUMO3 SUMO2	6.12e-04	47	66	3	PF00240
Domain	UBIQUITIN_2	SUMO4 SUMO3 SUMO2	9.19e-04	54	66	3	PS50053
Domain	Ubiquitin_dom	SUMO4 SUMO3 SUMO2	1.13e-03	58	66	3	IPR000626
Domain	FCH_dom	NOSTRIN ARHGAP45	2.97e-03	23	66	2	IPR001060
Domain	F_BAR	NOSTRIN ARHGAP45	3.50e-03	25	66	2	IPR031160
Domain	F_BAR	NOSTRIN ARHGAP45	3.50e-03	25	66	2	PS51741
Domain	Ank_2	TRPC7 ANKRD34B ANKRD18A AGAP2	7.05e-03	215	66	4	PF12796
Pathway	BIOCARTA_SUMO_PATHWAY	SUMO4 SUMO3 SUMO2	1.20e-06	7	47	3	MM1570
Pathway	REACTOME_SUMO_IS_PROTEOLYTICALLY_PROCESSED	SUMO4 SUMO3 SUMO2	1.20e-06	7	47	3	MM14928
Pathway	REACTOME_PROCESSING_AND_ACTIVATION_OF_SUMO	SUMO4 SUMO3 SUMO2	5.63e-06	11	47	3	MM14937
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_FACTORS	SUMO4 SUMO3 SUMO2	1.89e-05	16	47	3	MM14938
Pathway	REACTOME_SUMOYLATION_OF_INTRACELLULAR_RECEPTORS	SUMO4 SUMO3 SUMO2	1.07e-04	28	47	3	MM15042
Pathway	REACTOME_SUMO_IS_CONJUGATED_TO_E1_UBA2_SAE1	SUMO3 SUMO2	1.08e-04	5	47	2	M27223
Pathway	BIOCARTA_SUMO_PATHWAY	SUMO3 SUMO2	1.62e-04	6	47	2	M22055
Pathway	REACTOME_SUMO_IS_PROTEOLYTICALLY_PROCESSED	SUMO3 SUMO2	1.62e-04	6	47	2	M27225
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	BLM SUMO4 SUMO3 SUMO2	1.72e-04	84	47	4	MM14929
Pathway	REACTOME_SUMO_IS_TRANSFERRED_FROM_E1_TO_E2_UBE2I_UBC9	SUMO3 SUMO2	2.26e-04	7	47	2	M27224
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	SUMO4 SUMO3 SUMO2	3.15e-04	40	47	3	MM15000
Pathway	REACTOME_RHOF_GTPASE_CYCLE	ARHGAP32 DIAPH1 AKAP12	3.39e-04	41	47	3	MM15630
Pathway	REACTOME_RHOF_GTPASE_CYCLE	ARHGAP32 DIAPH1 AKAP12	3.64e-04	42	47	3	M41821
Pathway	REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER	SUMO4 SUMO3 SUMO2	4.47e-04	45	47	3	MM15302
Pathway	REACTOME_PROCESSING_AND_ACTIVATION_OF_SUMO	SUMO3 SUMO2	4.81e-04	10	47	2	M27235
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	SUMO4 SUMO3 SUMO2	6.47e-04	51	47	3	MM15151
Pathway	REACTOME_SUMOYLATION_OF_IMMUNE_RESPONSE_PROTEINS	SUMO4 SUMO3	7.03e-04	12	47	2	MM15157
Pathway	REACTOME_RHOD_GTPASE_CYCLE	ARHGAP32 DIAPH1 AKAP12	7.24e-04	53	47	3	M41811
Pathway	BIOCARTA_EXTRINSIC_PATHWAY	FGG F5	8.29e-04	13	47	2	M4470
Pathway	BIOCARTA_EXTRINSIC_PATHWAY	FGG F5	8.29e-04	13	47	2	MM1395
Pathway	REACTOME_RHOD_GTPASE_CYCLE	ARHGAP32 DIAPH1 AKAP12	1.25e-03	64	47	3	MM15601
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	SUMO4 SUMO3 SUMO2	1.31e-03	65	47	3	MM15147
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION_TERMINATION	UPF3B SNRPE THOC5	1.43e-03	67	47	3	M27694
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_FACTORS	SUMO3 SUMO2	1.99e-03	20	47	2	M27237
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	BLM SUMO3 SUMO2	2.14e-03	77	47	3	M27226
Pathway	REACTOME_SUMOYLATION	BLM SUMO4 SUMO3 SUMO2	2.38e-03	169	47	4	MM14919
Pathway	WP_BLOOD_CLOTTING_CASCADE	FGG F5	2.41e-03	22	47	2	M39480
Pathway	REACTOME_COMMON_PATHWAY_OF_FIBRIN_CLOT_FORMATION	FGG F5	2.41e-03	22	47	2	M17879
Pathway	REACTOME_COMMON_PATHWAY_OF_FIBRIN_CLOT_FORMATION	FGG F5	2.41e-03	22	47	2	MM14558
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	SRSF10 UPF3B SNRPE SF3B2 THOC5	2.42e-03	283	47	5	M13087
Pathway	BIOCARTA_INTRINSIC_PATHWAY	FGG F5	2.63e-03	23	47	2	M15997
Pathway	BIOCARTA_INTRINSIC_PATHWAY	FGG F5	2.63e-03	23	47	2	MM1427
Pathway	WP_BLOOD_CLOTTING_CASCADE	FGG F5	2.63e-03	23	47	2	MM15936
Pathway	REACTOME_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR_GG_NER	SUMO4 SUMO3 SUMO2	2.65e-03	83	47	3	MM15305
Pubmed	Small ubiquitin-related modifier (SUMO) binding determines substrate recognition and paralog-selective SUMO modification.	BLM SUMO4 SUMO3 SUMO2	1.26e-11	4	67	4	18708356
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	BLM MYL12A BPTF SRSF10 CENPC RRP1B ARID4A ATAD5 AHCTF1 NOC3L SUMO2 CCDC86 TADA3 HDGFL2 SF3B2	3.07e-10	954	67	15	36373674
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	BLM BPTF CENPC RRP1B ARID4A ATAD5 ZNF570 AHCTF1 SUMO3 CCDC86 HDGFL2 HOMEZ	1.83e-09	608	67	12	36089195
Pubmed	Stress-induced inactivation of the c-Myb transcription factor through conjugation of SUMO-2/3 proteins.	SUMO4 SUMO3 SUMO2	6.83e-09	3	67	3	17077080
Pubmed	Retinoic acid modulates the subcellular localization of small ubiquitin-related modifier-2/3 (SUMO-2/3) in the testis.	SUMO4 SUMO3 SUMO2	6.83e-09	3	67	3	20075418
Pubmed	Transient ischemia induces massive nuclear accumulation of SUMO2/3-conjugated proteins in spinal cord neurons.	SUMO4 SUMO3 SUMO2	6.83e-09	3	67	3	22945749
Pubmed	SUMO2/3 conjugation is an endogenous neuroprotective mechanism.	SUMO4 SUMO3 SUMO2	6.83e-09	3	67	3	21863037
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	BLM CENPC SLC25A40 RRP1B TRPM7 ATAD5 AHCTF1 NOC3L MRPS5 PGD TADA3 SNRPE HDGFL2 SF3B2 THOC5 AKAP12	1.64e-08	1487	67	16	33957083
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	BLM BPTF SRSF10 RRP1B ARID4A ATAD5 AHCTF1 SUMO3 CCDC86 TADA3 SNRPE HDGFL2 SF3B2 THOC5 HOMEZ	1.88e-08	1294	67	15	30804502
Pubmed	Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories.	SUMO4 SUMO3 SUMO2	2.73e-08	4	67	3	24690371
Pubmed	Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model.	SUMO4 SUMO3 SUMO2	2.73e-08	4	67	3	21843595
Pubmed	mRNA expression analysis of the SUMO pathway genes in the adult mouse retina.	SUMO4 SUMO3 SUMO2	2.73e-08	4	67	3	25617419
Pubmed	The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.	SUMO4 SUMO3 SUMO2	2.73e-08	4	67	3	31625212
Pubmed	SUMO proteins are involved in the stress response during spermatogenesis and are localized to DNA double-strand breaks in germ cells.	SUMO4 SUMO3 SUMO2	2.73e-08	4	67	3	20385780
Pubmed	The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability.	SUMO4 SUMO3 SUMO2	6.81e-08	5	67	3	27343429
Pubmed	Super Resolution Microscopy of SUMO Proteins in Neurons.	SUMO4 SUMO3 SUMO2	6.81e-08	5	67	3	31749687
Pubmed	Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways.	SUMO4 SUMO3 SUMO2	6.81e-08	5	67	3	17012228
Pubmed	The mouse small ubiquitin-like modifier-2 (SUMO-2) inhibits interleukin-12 (IL-12) production in mature dendritic cells by blocking the translocation of the p65 subunit of NFκB into the nucleus.	SUMO4 SUMO3 SUMO2	6.81e-08	5	67	3	21632113
Pubmed	Small ubiquitin-like modifier 2 (SUMO2) is critical for memory processes in mice.	SUMO4 SUMO3 SUMO2	6.81e-08	5	67	3	32910521
Pubmed	Temporal and SUMO-specific SUMOylation contribute to the dynamics of Polo-like kinase 1 (PLK1) and spindle integrity during mouse oocyte meiosis.	SUMO4 SUMO3 SUMO2	6.81e-08	5	67	3	29269218
Pubmed	Sumoylation differentially regulates Sp1 to control cell differentiation.	SUMO4 SUMO3 SUMO2	6.81e-08	5	67	3	24706897
Pubmed	Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease.	SUMO4 SUMO3 SUMO2	6.81e-08	5	67	3	25448527
Pubmed	Characterization of mouse ubiquitin-like SMT3A and SMT3B cDNAs and gene/pseudogenes.	SUMO4 SUMO3 SUMO2	6.81e-08	5	67	3	9891849
Pubmed	Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is linked to the development of diabetic retinopathy in mice.	SUMO4 SUMO3 SUMO2	6.81e-08	5	67	3	37890757
Pubmed	Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex.	SUMO4 SUMO3 SUMO2	6.81e-08	5	67	3	18644859
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	BLM MYL12A SUMO4 SRSF10 SLC25A40 RRP1B ATAD5 AHCTF1 NOC3L MRPS5 CCDC86 TADA3 SNRPE HDGFL2 RBFA	1.26e-07	1497	67	15	31527615
Pubmed	Stress-induced phosphorylation of Thr486 in c-Myb by p38 mitogen-activated protein kinases attenuates conjugation of SUMO-2/3.	SUMO4 SUMO3 SUMO2	1.36e-07	6	67	3	24257756
Pubmed	Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3.	SUMO4 SUMO3 SUMO2	1.36e-07	6	67	3	19033381
Pubmed	Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3.	SUMO4 SUMO3 SUMO2	1.36e-07	6	67	3	18948745
Pubmed	Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development.	SUMO4 SUMO3 SUMO2	1.36e-07	6	67	3	15923632
Pubmed	SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity.	SUMO4 SUMO3 SUMO2	1.36e-07	6	67	3	34875212
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	BLM MYL12A BPTF SRSF10 CENPC RRP1B NOC3L MRPS5 SUMO2 CCDC86 SNRPE SF3B2	3.72e-07	989	67	12	36424410
Pubmed	SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development.	SUMO4 SUMO3 SUMO2	3.80e-07	8	67	3	24891386
Pubmed	Human transcription factor protein interaction networks.	BLM MYL12A BPTF ARHGAP32 PYGO2 RRP1B ARID4A ATAD5 NOC3L MRPS5 SUMO2 CCDC86 TADA3 HOMEZ	4.66e-07	1429	67	14	35140242
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	BLM BPTF CENPC ATAD5 DIAPH1 SUMO3 SUMO2 PGD TADA3 HDGFL2 SF3B2 THOC5	4.85e-07	1014	67	12	32416067
Pubmed	Spatiotemporal distribution of SUMOylation components during mouse brain development.	SUMO4 SUMO3 SUMO2	8.12e-07	10	67	3	24639124
Pubmed	Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development.	SUMO4 SUMO3 SUMO2	1.12e-06	11	67	3	27009683
Pubmed	Foxp1 regulation of neonatal vocalizations via cortical development.	SUMO4 SUMO3 SUMO2	1.93e-06	13	67	3	29138280
Pubmed	Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.	SUMO4 SUMO3 SUMO2	3.06e-06	15	67	3	22155005
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	SRSF10 RRP1B NOC3L MRPS5 CCDC86 SF3B2 HOMEZ	3.47e-06	330	67	7	33301849
Pubmed	Correlation of increased hippocampal Sumo3 with spatial learning ability in old C57BL/6 mice.	SUMO4 SUMO3	3.66e-06	2	67	2	22595540
Pubmed	Genetics of type 1 diabetes in Asian and Caucasian populations.	SUMO4 PTPN22	3.66e-06	2	67	2	17452059
Pubmed	Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways.	SUMO4 SUMO3	3.66e-06	2	67	2	24569813
Pubmed	SUMO2 and SUMO3 transcription is differentially regulated by oxidative stress in an Sp1-dependent manner.	SUMO3 SUMO2	3.66e-06	2	67	2	21291420
Pubmed	Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3.	SUMO3 SUMO2	3.66e-06	2	67	2	10692421
Pubmed	Platelets contain tissue factor pathway inhibitor-2 derived from megakaryocytes and inhibits fibrinolysis.	TFPI2 F5	3.66e-06	2	67	2	25262870
Pubmed	Small ubiquitin-related modifier (SUMO) 3 and SUMO4 gene polymorphisms in Parkinson's disease.	SUMO4 SUMO3	3.66e-06	2	67	2	32237992
Pubmed	SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response.	SUMO3 SUMO2	3.66e-06	2	67	2	29891701
Pubmed	The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle.	SUMO3 SUMO2	3.66e-06	2	67	2	18565875
Pubmed	Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival.	SUMO3 SUMO2	3.66e-06	2	67	2	25047847
Pubmed	SUMO-2/3 conjugates accumulating under heat shock or MG132 treatment result largely from new protein synthesis.	SUMO3 SUMO2	3.66e-06	2	67	2	22306003
Pubmed	SUMOylation of nuclear actin.	SUMO3 SUMO2	3.66e-06	2	67	2	19635839
Pubmed	SENP3-regulated Nodal signaling plays a potential role in cardiac left-right asymmetry development.	SUMO4 SUMO3 SUMO2	3.76e-06	16	67	3	38925188
Pubmed	Ikaros SUMOylation: switching out of repression.	SUMO4 SUMO3 SUMO2	4.56e-06	17	67	3	15767674
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	MYL12A SRSF10 RRP1B SUMO2 F5 CCDC86 SNRPE HDGFL2 THOC5	4.85e-06	660	67	9	32780723
Pubmed	SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia.	SUMO4 SUMO3 SUMO2	5.46e-06	18	67	3	17981124
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	MYL12A IQCH RRP1B AHCTF1 FGG PGD SNRPE SF3B2	6.45e-06	513	67	8	25798074
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	CENPC RRP1B NOC3L SUMO2 HDGFL2	1.02e-05	148	67	5	32538781
Pubmed	Specification of SUMO1- and SUMO2-interacting motifs.	BLM SUMO3 SUMO2	1.03e-05	22	67	3	16524884
Pubmed	Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.	SUMO4 SUMO3 SUMO2	1.03e-05	22	67	3	27717094
Pubmed	Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3-dependent cytotoxicity.	SUMO3 SUMO2	1.10e-05	3	67	2	28747609
Pubmed	Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men.	SUMO3 SUMO2	1.10e-05	3	67	2	18694876
Pubmed	Small Ubiquitin-like Modifier Alters IFN Response.	SUMO3 SUMO2	1.10e-05	3	67	2	26223657
Pubmed	Thrombosis Related ABO, F5, MTHFR, and FGG Gene Polymorphisms in Morbidly Obese Patients.	FGG F5	1.10e-05	3	67	2	27999448
Pubmed	Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains.	SUMO3 SUMO2	1.10e-05	3	67	2	26223632
Pubmed	Activation of Protein Kinase A Stimulates SUMOylation, Expression, and Transport Activity of Organic Anion Transporter 3.	SUMO3 SUMO2	1.10e-05	3	67	2	30761470
Pubmed	Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen.	SUMO3 SUMO2	1.10e-05	3	67	2	30926672
Pubmed	SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.	SUMO3 SUMO2	1.10e-05	3	67	2	18374647
Pubmed	SUMOylation of HSP27 by small ubiquitin-like modifier 2/3 promotes proliferation and invasion of hepatocellular carcinoma cells.	SUMO3 SUMO2	1.10e-05	3	67	2	28665748
Pubmed	Sumoylation dynamics during keratinocyte differentiation.	SUMO3 SUMO2	1.10e-05	3	67	2	17164289
Pubmed	Opposing biological functions of the cytoplasm and nucleus DAXX modified by SUMO-2/3 in gastric cancer.	SUMO3 SUMO2	1.10e-05	3	67	2	32641734
Pubmed	SUMO paralogue-specific functions revealed through systematic analysis of human knockout cell lines and gene expression data.	SUMO3 SUMO2	1.10e-05	3	67	2	34232706
Pubmed	Fibrinogen alpha and gamma genes and factor VLeiden in children with thromboembolism: results from 2 family-based association studies.	FGG F5	1.10e-05	3	67	2	19515723
Pubmed	Different SUMO paralogues determine the fate of wild-type and mutant CFTRs: biogenesis versus degradation.	SUMO3 SUMO2	1.10e-05	3	67	2	30403549
Pubmed	The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi's sarcoma associated herpesvirus reactivation.	SUMO3 SUMO2	1.10e-05	3	67	2	24267727
Pubmed	SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family.	SUMO3 SUMO2	1.10e-05	3	67	2	9119407
Pubmed	In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides.	CENPC SUMO2	1.10e-05	3	67	2	15272016
Pubmed	Reduced thrombin generation increases host susceptibility to group A streptococcal infection.	FGG F5	1.10e-05	3	67	2	19056689
Pubmed	Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival.	SUMO3 SUMO2	1.10e-05	3	67	2	23078246
Pubmed	Fibrinogen γ' increases the sensitivity to activated protein C in normal and factor V Leiden plasma.	FGG F5	1.10e-05	3	67	2	24951429
Pubmed	SUMO2/3 promotes the progression and oxaliplatin resistance of colorectal cancer through facilitating the SUMOylation at Ku80-K307.	SUMO3 SUMO2	1.10e-05	3	67	2	37338025
Pubmed	Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa.	SUMO3 SUMO2	1.10e-05	3	67	2	23077236
Pubmed	Splenic SUMO1 controls systemic inflammation in experimental sepsis.	SUMO4 SUMO3	1.10e-05	3	67	2	37520526
Pubmed	SUMO2/3 modification of activating transcription factor 5 (ATF5) controls its dynamic translocation at the centrosome.	SUMO3 SUMO2	1.10e-05	3	67	2	29326161
Pubmed	NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.	SUMO3 SUMO2	1.10e-05	3	67	2	34504059
Pubmed	Distinct in vivo dynamics of vertebrate SUMO paralogues.	SUMO3 SUMO2	1.10e-05	3	67	2	15456902
Pubmed	Small ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma.	SUMO3 SUMO2	1.10e-05	3	67	2	26458400
Pubmed	Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation.	SUMO4 SUMO3 SUMO2	1.18e-05	23	67	3	30992372
Pubmed	A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.	BLM SUMO3 SUMO2	1.34e-05	24	67	3	16620772
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	SRSF10 RRP1B HDGFL2 SF3B2 THOC5	1.62e-05	163	67	5	22113938
Pubmed	Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal.	KCNC2 ASIP CHRNA1	1.72e-05	26	67	3	7905852
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	BLM BPTF RRP1B AHCTF1 HDGFL2 SF3B2	1.81e-05	283	67	6	30585729
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	SRSF10 RRP1B SUMO3 FGG CCDC86 SNRPE SF3B2	1.93e-05	430	67	7	38172120
Pubmed	SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development.	SUMO4 SUMO3 SUMO2	1.93e-05	27	67	3	20417598
Pubmed	Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage.	SUMO3 SUMO2	2.19e-05	4	67	2	25406032
Pubmed	Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.	SUMO3 SUMO2	2.19e-05	4	67	2	15487983
Pubmed	Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth.	SUMO3 SUMO2	2.19e-05	4	67	2	17428805
Pubmed	MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity.	SUMO3 SUMO2	2.19e-05	4	67	2	21900752
Pubmed	Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3.	SUMO3 SUMO2	2.19e-05	4	67	2	12810706
Pubmed	A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.	SUMO3 SUMO2	2.19e-05	4	67	2	15296745
Interaction	SMC5 interactions	BLM MYL12A BPTF SRSF10 CENPC RRP1B ARID4A ATAD5 AHCTF1 NOC3L SUMO2 CCDC86 TADA3 HDGFL2 SF3B2	7.49e-07	1000	67	15	int:SMC5
Interaction	H3C3 interactions	BLM BPTF CENPC RRP1B ARID4A ATAD5 AHCTF1 SUMO3 CCDC86 HDGFL2	5.16e-06	495	67	10	int:H3C3
Interaction	H2BC8 interactions	BLM BPTF CENPC ARID4A ATAD5 AHCTF1 UPF3B CCDC86 TADA3 HDGFL2	1.93e-05	576	67	10	int:H2BC8
Interaction	LHX2 interactions	BLM ARHGAP32 RRP1B NOC3L MRPS5 HOMEZ	3.26e-05	183	67	6	int:LHX2
Interaction	CENPA interactions	BLM BPTF CENPC RRP1B ATAD5 NOC3L DIAPH1 HDGFL2	3.47e-05	377	67	8	int:CENPA
Interaction	SNRNP40 interactions	BLM SRSF10 CENPC RRP1B ATAD5 AHCTF1 NOC3L TADA3 SNRPE HDGFL2	4.53e-05	637	67	10	int:SNRNP40
Interaction	SUMO3 interactions	BLM SUMO3 SUMO2 PGD HOMEZ	6.25e-05	126	67	5	int:SUMO3
Interaction	OASL interactions	CENPC RRP1B NOC3L CCDC86 SNRPE SF3B2	9.76e-05	223	67	6	int:OASL
Interaction	ZBTB2 interactions	SRSF10 RRP1B NOC3L MRPS5 SUMO2 CCDC86 SF3B2 HOMEZ	1.20e-04	450	67	8	int:ZBTB2
Interaction	NEK4 interactions	BLM MYL12A IQCH RRP1B AHCTF1 FGG PGD SNRPE SF3B2	1.26e-04	582	67	9	int:NEK4
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	NOSTRIN ARHGAP45	1.35e-03	23	43	2	1288
GeneFamily	Transient receptor potential cation channels	TRPC7 TRPM7	2.01e-03	28	43	2	249
GeneFamily	Ankyrin repeat domain containing	ANKRD34B ANKRD18A ANKRD18B AGAP2	2.57e-03	242	43	4	403
Coexpression	WHITFIELD_CELL_CYCLE_S	BLM SRSF10 ASIP ABCC5 ANKRD18A TTLL7	2.38e-06	150	67	6	M2075
Computational	Neighborhood of CTBP1	DIAPH1 SUMO3 SUMO2 TADA3 SNRPE SF3B2	4.39e-05	168	42	6	MORF_CTBP1
Computational	Neighborhood of KPNB1	SRSF10 NOC3L SNRPE SF3B2	1.80e-04	73	42	4	GNF2_KPNB1
Computational	Neighborhood of AP2M1	SUMO3 SUMO2 PGD TADA3 SNRPE SF3B2	1.81e-04	217	42	6	MORF_AP2M1
Computational	Neighborhood of HDAC1	DIAPH1 SUMO3 SUMO2 TADA3 SNRPE SF3B2	4.22e-04	254	42	6	MORF_HDAC1
Disease	mean platelet volume	ARHGAP32 ARID4A SYTL4 ATAD5 CCDC62 DIAPH1 ABCC5 ARHGAP45 TRIM48 HOMEZ	6.49e-05	1020	64	10	EFO_0004584
Disease	venous thromboembolism, factor VII measurement	ASIP FGG F5	7.78e-05	38	64	3	EFO_0004286, EFO_0004619
Disease	Colorectal Carcinoma	DNAH3 TRPM7 TFPI2 CCDC62 ABCC5 GATA5 F5 AKAP12	1.35e-04	702	64	8	C0009402
Disease	serum gamma-glutamyl transferase measurement	BPTF IQCH TRPM7 SYTL4 NOC3L SUMO3 SUMO2 CGNL1 TRIM48	1.51e-04	914	64	9	EFO_0004532
Disease	Myasthenia gravis	PTPN22 CHRNA1	3.56e-04	13	64	2	EFO_0004991
Disease	chemokine (C-C motif) ligand 27 measurement	LRRC7 F5 ANKRD18B	4.80e-04	70	64	3	EFO_0008082
Disease	Ischemic stroke, venous thromboembolism, stroke, Abnormal thrombosis, deep vein thrombosis, pulmonary embolism	FGG F5	6.17e-04	17	64	2	EFO_0000712, EFO_0003827, EFO_0003907, EFO_0004286, HP_0001977, HP_0002140
Disease	late-onset myasthenia gravis	PTPN22 CHRNA1	6.93e-04	18	64	2	EFO_1001490
Disease	urticaria	PTPN22 ITPKB	8.58e-04	20	64	2	EFO_0005531
Disease	prothrombin time measurement	FGG F5	9.47e-04	21	64	2	EFO_0008390
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	FGG F5	9.47e-04	21	64	2	EFO_0004286, EFO_0004792
Disease	venous thromboembolism, tissue plasminogen activator measurement	FGG F5	1.14e-03	23	64	2	EFO_0004286, EFO_0004791
Disease	partial thromboplastin time	FGG F5	1.24e-03	24	64	2	EFO_0004310
Disease	D dimer measurement	FGG F5	1.94e-03	30	64	2	EFO_0004507
Disease	factor XI measurement, venous thromboembolism	FGG F5	1.94e-03	30	64	2	EFO_0004286, EFO_0004694
Disease	melanoma	IQCH TFPI2 ASIP HPSE	2.08e-03	248	64	4	C0025202
Disease	sensorineural hearing loss (is_implicated_in)	DIAPH1 F5	2.34e-03	33	64	2	DOID:10003 (is_implicated_in)
Disease	factor VIII measurement, venous thromboembolism	FGG F5	2.48e-03	34	64	2	EFO_0004286, EFO_0004630
Disease	Colorectal Neoplasms	TRPM7 TFPI2 ABCC5 GATA5	3.10e-03	277	64	4	C0009404
Disease	ascending aortic diameter	DCDC1 ATAD5 NOC3L	3.53e-03	140	64	3	EFO_0021787
Disease	venous thromboembolism, von Willebrand factor measurement	FGG F5	3.77e-03	42	64	2	EFO_0004286, EFO_0004629
Disease	liver cirrhosis (is_implicated_in)	CENPC F5	3.95e-03	43	64	2	DOID:5082 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RKIMAARQKKRTPTK	TADA3	396	O75528
KPKKRKLFRRFMSEN	nan	61	A8MT66
RMKFTRISTPKKSKK	ATAD5	656	Q96QE3
KKRFSQMLQDKPLRT	CCDC86	251	Q9H6F5
GLMAKKQKRTPKRTS	ARID4A	1081	P29374
TAAMKPANLKKRKER	ANKRD18A	271	Q8IVF6
SIFKPSKMQRIVRLK	CCDC62	536	Q6P9F0
ASFKKMVTPKKRVRR	AKAP12	611	Q02952
TAAMKPENLKKRKKR	ANKRD18B	271	A2A2Z9
QSLKEMVSKLKKPRR	PGD	56	P52209
PSPMVKKQRRKKLTT	AGAP2	826	Q99490
KTFMPSLVVKKQRAK	C8orf58	346	Q8NAV2
RFTSMRIKKEKEKPN	DIAPH1	51	O60610
RDKVKLMKFSRPKKT	BPTF	1811	Q12830
RSSKKEASMKKVVRP	ASIP	71	P42127
KTKKFKIPTMRVTNR	CCDC60	216	Q8IWA6
MSSKRTKTKTKKRPQ	MYL12A	1	P19105
LTTQMKKGRKRAKPR	RBFA	271	Q8N0V3
KAMKVKTPLRALKSL	IQCH	251	Q86VS3
FTRSKSLKILRNMKK	PTPN22	746	Q9Y2R2
FSTMKRPSREKQDKK	CHRNA1	346	P02708
IFPKEFKSKKMLLRR	ANKRD34B	486	A5PLL1
RKTKPVLSIRMKKLT	DCDC1	276	M0R2J8
KNPRMKVKNRLFAKS	DCDC1	1501	M0R2J8
SLAMAKQKLPRKRKK	KCNC2	481	Q96PR1
KRELMKTPSISKKNR	ARHGAP45	6	Q92619
RLSPLMKDIKSNKFK	LRRC7	931	Q96NW7
KRAPMEKATTKKRTL	LIMK2	481	P53671
SQRPKLKRVMKEKTK	CCDC28A	136	Q8IWP9
SKRKHRKIPFSKRKM	PARP4	1236	Q9UKK3
LRTFMKSRPTKQKLK	ARHGAP32	346	A7KAX9
FPLERKRPQNKMKKS	ARHGAP32	641	A7KAX9
KRKTPALKMSVSKRA	HDGFL2	156	Q7Z4V5
PRRKTAKMLKSFLKA	HPSE	271	Q9Y251
LQMKSPEKKRRKSNT	PYGO2	36	Q9BRQ0
KLTPKMKKDKRASRG	ABCC5	511	O15440
KTTPLLSFLKNKQRM	UPF3B	196	Q9BZI7
KKTTMKIIPFNRLTI	FGG	406	P02679
AMKKESIQTRKRKPK	GATA5	281	Q9BWX5
FASKTRNERKRKKMP	BLM	1326	P54132
EPMRKKTKFSSRNKE	DNAH3	156	Q8TD57
TIKQKQRRKFMAKPA	CENPC	416	Q03188
NSMKKDLRLKKLPSK	CGNL1	1251	Q0VF96
MASPDRSKRKILKAK	ATF7IP2	1	Q5U623
RSKRKILKAKKTMPL	ATF7IP2	6	Q5U623
KKLSSYPKQILRRKM	AHCTF1	2251	Q8WYP5
SPDMQRQRKTKRKTK	HOMEZ	351	Q8IX15
MKARRNKKQIPSFRK	NOC3L	1	Q8WTT2
SAMDKERRKSLLKPK	NOSTRIN	291	Q8IVI9
LRFKRTHIKMKKQPK	MRPS5	296	P82675
MIFKKNTRKILRPSE	SYTL4	256	Q96C24
KTNIRLKKMASLARK	TRIM48	81	Q8IWZ4
PSQKTASLKKRKKMR	RRP1B	586	Q14684
PLELIRTKMQSKKFS	SLC25A40	161	Q8TBP6
MNSSPRSKKLRLKFR	F5	666	P12259
LTKARKKPSLRKDMY	ITPKB	756	P27987
RKRMFTPRKLKLTLF	CLBA1	306	Q96F83
FKIKRHTPLSKLMKA	SUMO3	31	P55854
APKLSKKKLRRMNRF	SF3B2	446	Q13435
QPKKEMKAKSRSRSA	SRSF10	186	O75494
SKKLRVGLLKMRNKS	PRSS35	181	Q8N3Z0
QFKIKRHTPLSKLMK	SUMO2	31	P61956
SKTKSRKQLGRIMLK	SNRPE	66	P62304
KRSFKKNLMAIKPKS	ZNF570	196	Q96NI8
QFKIKRQTPLSKLMK	SUMO4	31	Q6EEV6
KKMPKLRFASRIRKI	TFPI2	216	P48307
MSSESSKKRKPKVIR	THOC5	1	Q13769
EIQMKSKKLPITRKF	TRPM7	831	Q96QT4
ELPYQSTMKRKVRKK	TTLL7	21	Q6ZT98
KPTRYQKIMKRLIKR	TRPC7	776	Q9HCX4
GPKKKKMTKARLERF	NEUROD4	71	Q9HD90