Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlactate transmembrane transporter activity

SLC16A3 SLC16A8

3.72e-056322GO:0015129
GeneOntologyBiologicalProcesslactate transport

SLC16A3 SLC16A8

7.82e-059312GO:0015727
GeneOntologyBiologicalProcesslactate transmembrane transport

SLC16A3 SLC16A8

7.82e-059312GO:0035873
MousePhenoepididymis epithelium degeneration

BMP8B BMP8A

6.44e-063212MP:0004934
MousePhenoepididymis degeneration

BMP8B BMP8A

4.49e-057212MP:0004935
DomainEamA_dom

SLC35G5 SLC35G6 SLC35C1 SLC35G4

5.35e-0914304IPR000620
DomainEamA

SLC35G5 SLC35G6 SLC35C1 SLC35G4

5.35e-0914304PF00892
DomainMCT

SLC16A3 SLC16A8

2.49e-055302IPR004743
DomainInhibin_asu

BMP8B BMP8A

1.92e-0413302IPR002405
DomainMFS

SLC16A3 SLC16A8 SLC22A31

6.81e-04108303PS50850
DomainTGFb_propeptide

BMP8B BMP8A

9.19e-0428302PF00688
DomainTGF-b_N

BMP8B BMP8A

9.19e-0428302IPR001111
DomainTGF-beta-rel

BMP8B BMP8A

1.20e-0332302IPR015615
DomainTGFb_CS

BMP8B BMP8A

1.20e-0332302IPR017948
DomainMFS_dom

SLC16A3 SLC16A8 SLC22A31

1.27e-03134303IPR020846
DomainTGFB

BMP8B BMP8A

1.60e-0337302SM00204
DomainTGF-b_C

BMP8B BMP8A

1.60e-0337302IPR001839
DomainTGF_BETA_2

BMP8B BMP8A

1.60e-0337302PS51362
DomainTGF_BETA_1

BMP8B BMP8A

1.60e-0337302PS00250
DomainTGF_beta

BMP8B BMP8A

1.60e-0337302PF00019
DomainFN3

IL13RA1 PTPRH IL27RA

3.91e-03199303PS50853
DomainFN3_dom

IL13RA1 PTPRH IL27RA

4.49e-03209303IPR003961
Domain-

BMP8B BMP8A

5.17e-03673022.10.90.10
DomainCystine-knot_cytokine

BMP8B BMP8A

5.17e-0367302IPR029034
DomainMFS

SLC16A3 SLC16A8

6.77e-0377302IPR011701
DomainMFS_1

SLC16A3 SLC16A8

6.77e-0377302PF07690
PathwayREACTOME_PROTON_COUPLED_MONOCARBOXYLATE_TRANSPORT

SLC16A3 SLC16A8

2.86e-056202MM17217
PathwayREACTOME_PROTON_COUPLED_MONOCARBOXYLATE_TRANSPORT

SLC16A3 SLC16A8

2.86e-056202M27355
PathwayKEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY_BMP_ANTAGONIST

BMP8B BMP8A

1.99e-0415202M47824
PathwayKEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY

BMP8B BMP8A

3.58e-0420202M47843
PathwayREACTOME_BASIGIN_INTERACTIONS

SLC16A3 SLC16A8

5.18e-0424202MM17215
PathwayREACTOME_BASIGIN_INTERACTIONS

SLC16A3 SLC16A8

5.63e-0425202M4974
PathwayKEGG_MEDICUS_REFERENCE_IL6_FAMILY_TO_JAK_STAT_SIGNALING_PATHWAY

IL13RA1 IL27RA

6.57e-0427202M47906
Pubmed

RT-PCR of fatty acid elongases.

SLC35G5 SLC35G6 SLC35G4

2.83e-0943239056918
Pubmed

Emergence of primate genes by retrotransposon-mediated sequence transduction.

SLC35G5 SLC35G6 SLC35G4

2.83e-09432317101974
Pubmed

Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.

BMP8B BMP8A

8.20e-07232231940275
Pubmed

Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.

BMP8B BMP8A

8.20e-0723229463357
Pubmed

The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.

BMP8B BMP8A

8.20e-0723228682296
Pubmed

Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia.

SLC16A3 SLC16A8

8.20e-07232221199217
Pubmed

The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells.

BMP8B BMP8A

8.20e-07232221277400
Pubmed

Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).

BMP8B BMP8A

2.46e-06332212925636
Pubmed

BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.

BMP8B BMP8A

2.46e-06332222579288
Pubmed

Mutation in Bmp7 exacerbates the phenotype of Bmp8a mutants in spermatogenesis and epididymis.

BMP8B BMP8A

2.46e-06332211784057
Pubmed

Glucose affects monocarboxylate cotransporter (MCT) 1 expression during mouse preimplantation development.

SLC16A3 SLC16A8

2.46e-06332216514190
Pubmed

Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse.

BMP8B BMP8A

2.46e-0633229076678
Pubmed

Requirement of Bmp8b for the generation of primordial germ cells in the mouse.

BMP8B BMP8A

2.46e-06332210894154
Pubmed

Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a.

BMP8B BMP8A

2.46e-06332225451979
Pubmed

METTL14-Mediated m6A Modification of TUG1 Represses Ferroptosis in Alzheimer's Disease via Inhibiting GDF15 Ubiquitination.

TUG1 METTL14

2.46e-06332239206905
Pubmed

Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells.

SLC16A3 SLC16A8

4.92e-06432212657613
Pubmed

Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells.

BMP8B BMP8A

4.92e-0643229434160
Pubmed

Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development.

BMP8B BMP8A

4.92e-0643228843393
Pubmed

Cysteine 159 delineates a hinge region of the alternating access monocarboxylate transporter 1 and is targeted by cysteine-modifying inhibitors.

SLC16A3 SLC16A8

8.19e-06532233999492
Pubmed

Genetic expression of monocarboxylate transporters during human and murine oocyte maturation and early embryonic development.

SLC16A3 SLC16A8

8.19e-06532212056458
Pubmed

Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation.

BMP8B BMP8A

1.23e-0563229878243
Pubmed

Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development.

BMP8B BMP8A

1.23e-0563227605753
Pubmed

Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70).

SLC16A3 SLC16A8

1.23e-05632215917240
Pubmed

The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4.

BMP8B BMP8A

1.72e-0573229070944
Pubmed

Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat.

BMP8B BMP8A

1.72e-05732212107726
Pubmed

Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b.

BMP8B BMP8A

2.94e-05932215028287
Pubmed

Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.

BMP8B BMP8A

2.94e-0593221460021
Pubmed

Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein.

BMP8B BMP8A

4.49e-051132210721728
Pubmed

The glucose-lactic acid cycle and gluconeogenesis.

SLC16A3 SLC16A8

5.38e-05123227273846
Pubmed

Bmp7 regulates germ cell proliferation in mouse fetal gonads.

BMP8B BMP8A

6.36e-051332218391523
Pubmed

The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.

SLC16A3 SLC16A8

7.41e-051432212739169
Pubmed

New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice.

BMP8B BMP8A

7.41e-051432211526197
Pubmed

Global comparative transcriptome analysis of cartilage formation in vivo.

BMP8B BMP8A

9.76e-051632219272164
Pubmed

Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.

BMP8B BMP8A

1.11e-041732214736746
Pubmed

Dysfunction of programmed embryo senescence is linked to genetic developmental defects.

BMP8B BMP8A

1.24e-041832237017267
Pubmed

Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters.

SLC16A3 SLC16A8

1.24e-041832231791063
Pubmed

Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling.

BMP8B BMP8A SLC16A3

1.35e-0410832331202927
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

SLC35G5 SLC35G6 ATP1A2 MRGPRF SLC35G4

3.52e-0467432537196079
Pubmed

Forkhead box a2 (FOXA2) is essential for uterine function and fertility.

BMP8B BMP8A

4.25e-043332228049832
Pubmed

Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis.

BMP8B BMP8A

4.25e-043332232640236
Pubmed

Systematic identification of NF90 target RNAs by iCLIP analysis.

IL13RA1 IL27RA

6.58e-044132235013429
Cytoband1q23.2

VSIG8 ATP1A2

2.76e-04353221q23.2
Cytoband1p36.22

CLSTN1 KIAA2013

3.09e-04373221p36.22
Cytoband12q13.12

DDN NCKAP5L

3.26e-043832212q13.12
Cytoband22q12.2

TUG1 EMID1

7.59e-045832222q12.2
CytobandEnsembl 112 genes in cytogenetic band chr19p13

S1PR5 GPR108 ICAM5 IL27RA

2.20e-03797324chr19p13
CytobandEnsembl 112 genes in cytogenetic band chr1q23

VSIG8 ATP1A2

1.09e-02226322chr1q23
Cytoband19p13.2

S1PR5 ICAM5

1.11e-0222932219p13.2
CytobandEnsembl 112 genes in cytogenetic band chr22q12

TUG1 EMID1

1.17e-02235322chr22q12
CytobandEnsembl 112 genes in cytogenetic band chr1p36

CLSTN1 NR0B2 KIAA2013

1.17e-02681323chr1p36
GeneFamilySolute carriers

SLC35G5 SLC35G6 SLC16A3 SLC35C1 SLC16A8 SLC35G4 SLC22A31

1.37e-06395277752
GeneFamilyBone morphogenetic proteins|Astacins

BMP8B BMP8A

1.17e-0411272455
GeneFamilyCD molecules|I-set domain containing|Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing

IL13RA1 IL27RA

1.78e-0342272602
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K4ME2_AND_H3K27ME3

BMP8B BMP8A EMID1 IL27RA

9.71e-0762324MM829
CoexpressionBYSTRYKH_HEMATOPOIESIS_STEM_CELL_FGF3

BMP8B BMP8A

4.02e-058322M10331
CoexpressionMEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED

EVC BMP8B CLDN5 SLC16A3 EMID1 IL27RA

4.45e-05544326M1936
CoexpressionBYSTRYKH_HEMATOPOIESIS_STEM_CELL_FGF3

BMP8B BMP8A

5.17e-059322MM608
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K4ME2_AND_H3K27ME3

BMP8A EMID1 IL27RA

5.39e-0560323M1950
CoexpressionMEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED

EVC BMP8B CLDN5 SLC16A3 EMID1 IL27RA

6.00e-05574326MM820
CoexpressionMIKKELSEN_MEF_LCP_WITH_H3K27ME3

ATP1A2 NR0B2 SLC16A8

8.93e-0571323M1965
CoexpressionGSE3039_NKT_CELL_VS_B1_BCELL_UP

BMP8B BMP8A ATP1A2 KIAA2013

9.81e-05199324M6432
CoexpressionMIKKELSEN_MEF_LCP_WITH_H3K27ME3

ATP1A2 NR0B2 SLC16A8

1.14e-0477323MM839
CoexpressionAtlasDevelopingKidney_e15.5_S-shaped body_emap-27855_k-means-cluster#2_top-relative-expression-ranked_200

DDN IL13RA1 CLDN5

1.00e-0529313gudmap_developingKidney_e15.5_S-shaped body_200_k2
CoexpressionAtlasDevelopingKidney_e15.5_Podocyte cells_emap-27915_k-means-cluster#4_top-relative-expression-ranked_500

DDN IL13RA1 CLDN5

4.37e-0547313gudmap_developingKidney_e15.5_Podocyte cells_500_k4
CoexpressionAtlasDevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_k-means-cluster#4_top-relative-expression-ranked_100

DDN IL13RA1 CLDN5

5.93e-0552313gudmap_developingKidney_e15.5_stage III -IV renal corpusc_100_k4
CoexpressionAtlasDevelopingKidney_e15.5_S-shaped body_emap-27855_top-relative-expression-ranked_200

DDN IL13RA1 CLDN5 EMID1

8.75e-05162314gudmap_developingKidney_e15.5_S-shaped body_200
CoexpressionAtlasDevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_k-means-cluster#2_top-relative-expression-ranked_500

TSPAN4 DDN IL13RA1 CLDN5

1.49e-04186314gudmap_developingKidney_e15.5_stage III -IV renal corpusc_500_k2
CoexpressionAtlasDevelopingKidney_e15.5_S-shaped body_emap-27855_k-means-cluster#4_top-relative-expression-ranked_100

DDN CLDN5

2.44e-0416312gudmap_developingKidney_e15.5_S-shaped body_100_k4
CoexpressionAtlasDevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_top-relative-expression-ranked_100

DDN IL13RA1 CLDN5

2.48e-0484313gudmap_developingKidney_e15.5_stage III -IV renal corpusc_100
CoexpressionAtlasDevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_k-means-cluster#2_top-relative-expression-ranked_200

DDN IL13RA1 CLDN5

2.57e-0485313gudmap_developingKidney_e15.5_stage III -IV renal corpusc_200_k2
CoexpressionAtlasDevelopingKidney_e15.5_Podocyte cells_emap-27915_k-means-cluster#2_top-relative-expression-ranked_1000

DDN IL13RA1 CLDN5

2.57e-0485313gudmap_developingKidney_e15.5_Podocyte cells_1000_k2
CoexpressionAtlase8.5_ParaxMesoderm_top-relative-expression-ranked_500

TSPAN4 CLDN5 TUG1 SLC16A3 METTL14

3.40e-04423315Facebase_ST1_e8.5_ParaxMesoderm_500
CoexpressionAtlasDevelopingKidney_e15.5_S-shaped body_emap-27855_k-means-cluster#2_top-relative-expression-ranked_500

DDN IL13RA1 CLDN5

5.05e-04107313gudmap_developingKidney_e15.5_S-shaped body_500_k2
CoexpressionAtlasDevelopingKidney_e15.5_Podocyte cells_emap-27915_k-means-cluster#4_top-relative-expression-ranked_200

DDN CLDN5

5.12e-0423312gudmap_developingKidney_e15.5_Podocyte cells_200_k4
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DDN CLDN5 BMP8A MRGPRF

5.93e-06166324dc443a3327dc8f9a0d808c3c6e06b0834d45f5c2
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DDN CLDN5 VSIG8 MRGPRF

8.53e-06182324cde8fa4f42d25545abaa9ee885b4b1e24a5a8e08
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DDN CLDN5 VSIG8 MRGPRF

9.29e-061863241094c7140131454b2583200e1c01e81ccab3db23
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DDN CLDN5 VSIG8 MRGPRF

9.49e-0618732424c2a3962da364e46e98abeab5f8234376fa26bb
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DDN CLDN5 VSIG8 MRGPRF

9.69e-061883249db778c1d9e622a68337212296e3a1ed8f771fa5
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DDN CLDN5 VSIG8 MRGPRF

9.69e-06188324047c4e0b03fc8334e38c48977e41d26dbe229d47
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DDN CLDN5 VSIG8 MRGPRF

1.05e-05192324ef0aba777072429a6ab7dcfcc305673975946580
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DDN CLDN5 VSIG8 MRGPRF

1.07e-051933243eaa0461618582a1754400624350d269d24e750a
ComputationalGenes in the cancer module 27.

IL13RA1 PTPRH NR0B2 CHRNB2 IL27RA

3.93e-04355205MODULE_27
ComputationalGenes in the cancer module 218.

SLC16A3 SLC16A8

6.13e-0420202MODULE_218
ComputationalGenes in the cancer module 186.

SLC16A3 SLC16A8

6.13e-0420202MODULE_186
ComputationalGenes in the cancer module 71.

SLC16A3 SLC16A8

7.43e-0422202MODULE_71
ComputationalMembranal receptors.

TSPAN4 PTPRH SLC16A3 NR0B2 IL27RA

2.14e-03517205MODULE_64
ComputationalImmune (humoral) and inflammatory response.

TSPAN4 CLDN5 SLC16A3 NR0B2 IL27RA

2.72e-03546205MODULE_84
DrugBenzamil hydrochloride [2898-76-2]; Down 200; 11.2uM; HL60; HT_HG-U133A

DDN BMP8B SLC16A3 CYP2W1 IL27RA

6.69e-061983152200_DN
DiseaseICAM-1 measurement

S1PR5 ICAM5

3.10e-0424322EFO_0004520
Diseasediabetes mellitus (implicated_via_orthology)

BMP8B BMP8A

3.64e-0426322DOID:9351 (implicated_via_orthology)
Diseaselymphocyte count

S1PR5 PTPRH CLSTN1 ICAM5 EMID1 IL27RA

4.40e-031464326EFO_0004587

Protein segments in the cluster

PeptideGeneStartEntry
LLFLGLLGLWGLLCA

CYP2W1

6

Q8TAV3
LLAGLLCGGGVWAAR

CLSTN1

16

O94985
VLGAWGLRQGQGLLG

DDN

281

O94850
FGWRGGFLLLGGLLL

SLC16A8

171

O95907
LGGLLHWERLLGGLG

NCKAP5L

251

Q9HCH0
WRGGFLILGGLLLNC

SLC16A3

176

O15427
IFLWCGSGEGLDLGR

METTL14

231

Q9HCE5
ALLGLWAALGLGLFG

ICAM5

11

Q9UMF0
ILFLWGLFLLGCGLS

IL27RA

521

Q6UWB1
RLLQGCWGPLFLLGL

NR0B2

86

Q15466
RLCGLWALLLCAGGG

IL13RA1

6

P78552
IWLRGGLVLFGICTL

OTOP2

101

Q7RTS6
LLTCGIIIGGFWLGV

SLC35C1

171

Q96A29
CRQLFGGFSILLWIG

ATP1A2

91

P50993
GPLWLLGLTLCALGG

BMP8A

6

Q7Z5Y6
AWALLCLGLLLPGGG

EMID1

6

Q96A84
AALGLGLGLWLGCRA

EVC

36

P57679
GPLWLLGLALCALGG

BMP8B

6

P34820
HLLGWLLGCVILGAG

SLC22A31

136

A6NKX4
GLLPALGWNCLGRLD

S1PR5

166

Q9H228
GYEWCGLLGSILGLI

SLC35G5

156

Q96KT7
LCGLVGNGLVLWFFG

MRGPRF

56

Q96AM1
EWGQRLLLVLLLGGC

GPR108

16

Q9NPR9
LLGFGLLRLCSGVWG

CHRNB2

11

P17787
LEILGLVLCLVGWGG

CLDN5

6

O00501
GYDWCGLLGSILGLI

SLC35G4

156

P0C7Q5
GSLLALGCLAVGIWG

VSIG8

271

P0DPA2
GGWLVVGFLLCLFLL

TUG1

136

A0A6I8PU40
GYDWCGLLGSILGLI

SLC35G6

156

P0C7Q6
FNLLFWLGGCGVLGV

TSPAN4

16

O14817
GGLGVWGNLVLLGLC

PTPRH

6

Q9HD43
LGLLLLLLWFGGSGA

KIAA2013

26

Q8IYS2