Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncarbon-sulfur lyase activity

CENPVL2 CENPVL3 CENPVL1

7.14e-0616483GO:0016846
GeneOntologyMolecularFunctionzinc ion binding

ZZZ3 TRIM42 ESR1 ESRRA KMT2A FBXO11 KDM4A MIB2 TRIM40

2.35e-04891489GO:0008270
GeneOntologyMolecularFunctionestrogen response element binding

ESR1 ESRRA

3.07e-0411482GO:0034056
DomainOest_rcpt/oest-rel_rcp

ESR1 ESRRA

5.91e-055462IPR024178
DomainC345C

SFRP4 C3

7.88e-0417462SM00643
DomainZZ

ZZZ3 MIB2

8.85e-0418462PF00569
DomainZF_ZZ_2

ZZZ3 MIB2

8.85e-0418462PS50135
DomainZF_ZZ_1

ZZZ3 MIB2

8.85e-0418462PS01357
DomainZnf_ZZ

ZZZ3 MIB2

9.88e-0419462IPR000433
DomainNTR

SFRP4 C3

9.88e-0419462PF01759
DomainZnF_ZZ

ZZZ3 MIB2

9.88e-0419462SM00291
DomainNetrin_module_non-TIMP

SFRP4 C3

9.88e-0419462IPR018933
DomainEPHD

KMT2A KDM4A

1.33e-0322462PS51805
DomainNTR

SFRP4 C3

1.45e-0323462PS50189
DomainNetrin_domain

SFRP4 C3

1.45e-0323462IPR001134
DomainTIMP-like_OB-fold

SFRP4 C3

1.86e-0326462IPR008993
DomainZnf_RING/FYVE/PHD

TRIM42 KMT2A KDM4A MIB2 TRIM40

5.25e-03459465IPR013083
DomainZnf_FYVE_PHD

KMT2A KDM4A MOBP

5.66e-03147463IPR011011
Domainzf-C4

ESR1 ESRRA

5.73e-0346462PF00105
DomainZnf_hrmn_rcpt

ESR1 ESRRA

5.73e-0346462IPR001628
DomainNuclear_hrmn_rcpt

ESR1 ESRRA

5.73e-0346462IPR001723
DomainNUCLEAR_REC_DBD_2

ESR1 ESRRA

5.73e-0346462PS51030
DomainNUCLEAR_REC_DBD_1

ESR1 ESRRA

5.73e-0346462PS00031
DomainZnF_C4

ESR1 ESRRA

5.73e-0346462SM00399
Domain-

ESR1 ESRRA

5.98e-03474621.10.565.10
DomainHOLI

ESR1 ESRRA

6.23e-0348462SM00430
DomainNucl_hrmn_rcpt_lig-bd

ESR1 ESRRA

6.23e-0348462IPR000536
DomainHormone_recep

ESR1 ESRRA

6.23e-0348462PF00104
Pubmed

Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow.

CENPVL2 CENPVL3 CENPVL1

5.24e-08649327250503
Pubmed

JMJD2A mediates transcriptional activation of SFRP4 and regulates oxidative stress and mitochondrial dysfunction in heart failure.

SFRP4 KDM4A

1.94e-06249238411359
Pubmed

siRNA silencing of estrogen receptor-α expression specifically in medial preoptic area neurons abolishes maternal care in female mice.

ESR1 ESRRA

1.94e-06249222988120
Pubmed

Overexpression, purification, and crystal structure of native ER alpha LBD.

ESR1 ESRRA

1.94e-06249211437591
Pubmed

Increased adipose tissue in male and female estrogen receptor-alpha knockout mice.

ESR1 ESRRA

1.94e-06249211070086
Pubmed

Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions.

USP2 KMT2A

1.94e-06249230899083
Pubmed

Genomic amplification upregulates estrogen-related receptor alpha and its depletion inhibits oral squamous cell carcinoma tumors in vivo.

ESR1 ESRRA

1.94e-06249226639757
Pubmed

Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-alpha inverse agonist XCT790.

ESR1 ESRRA

1.94e-06249217631492
Pubmed

Reprogramming of the ERRα and ERα target gene landscape triggers tamoxifen resistance in breast cancer.

ESR1 ESRRA

1.94e-06249225643697
Pubmed

An estrogen receptor (ER)alpha deoxyribonucleic acid-binding domain knock-in mutation provides evidence for nonclassical ER pathway signaling in vivo.

ESR1 ESRRA

1.94e-06249212351685
Pubmed

The enhanced expression of estrogen-related receptor α in human bladder cancer tissues and the effects of estrogen-related receptor α knockdown on bladder cancer cells.

ESR1 ESRRA

1.94e-06249230977157
Pubmed

Expression of the estrogen-related receptor 1 (ERR-1) orphan receptor during mouse development.

ESR1 ESRRA

5.83e-0634929256346
Pubmed

Estrogen induces estrogen-related receptor alpha gene expression and chromatin structural changes in estrogen receptor (ER)-positive and ER-negative breast cancer cells.

ESR1 ESRRA

5.83e-06349218174157
Pubmed

Estrogen receptor alpha and estrogen receptor-related receptor alpha1 compete for binding and coactivator.

ESR1 ESRRA

5.83e-06349211165056
Pubmed

Estrogen-related receptor alpha 1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements.

ESR1 ESRRA

5.83e-0634929058380
Pubmed

Mixed lineage leukaemia histone methylases 1 collaborate with ERα to regulate HOXA10 expression in AML.

ESR1 KMT2A

5.83e-06349225307539
Pubmed

Estradiol mediates vasculoprotection via ERRα-dependent regulation of lipid and ROS metabolism in the endothelium.

ESR1 ESRRA

5.83e-06349226271712
Pubmed

Estrogen Receptor α (ERα) and Estrogen Related Receptor α (ERRα) are both transcriptional regulators of the Runx2-I isoform.

ESR1 ESRRA

5.83e-06349223403054
Pubmed

Estrogen-related receptor alpha expression and function is associated with the transcriptional coregulator AIB1 in breast carcinoma.

ESR1 ESRRA

5.83e-06349219491275
Pubmed

Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop.

ESR1 ESRRA

5.83e-06349218441008
Pubmed

Nuclear insulin receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters.

ESR1 ESRRA

5.83e-06349215318176
Pubmed

Chicken ovalbumin upstream promoter-transcription factor interacts with estrogen receptor, binds to estrogen response elements and half-sites, and inhibits estrogen-induced gene expression.

ESR1 ESRRA

5.83e-0634929395481
Pubmed

Expression of JMJD2A in infiltrating duct carcinoma was markedly higher than fibroadenoma, and associated with expression of ARHI, p53 and ER in infiltrating duct carcinoma.

ESR1 KDM4A

1.16e-05449223678541
Pubmed

Identification of proteins highly expressed in uterine fluid from mice with hydrometra.

ESR1 C3

1.16e-05449226393907
Pubmed

Akt/PTEN signaling mediates estrogen-dependent proliferation of primordial germ cells in vitro.

ESR1 ESRRA

1.16e-05449214525951
Pubmed

Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors.

ESR1 ESRRA

1.94e-05549218509053
Pubmed

Ligand-dependent transcription of estrogen receptor alpha is mediated by the ubiquitin ligase EFP.

ESR1 ESRRA

1.94e-05549217418098
Pubmed

The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).

ESR1 ESRRA

2.91e-05649212522104
Pubmed

Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes.

ESR1 ESRRA

2.91e-05649216439465
Pubmed

PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif.

ESR1 ESRRA

2.91e-05649211574675
Pubmed

Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development.

ESR1 KDM4A

4.07e-05749221445275
Pubmed

Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function.

TPR FBXO11

6.96e-05949223110726
Pubmed

Sex-hormone-driven innate antibodies protect females and infants against EPEC infection.

ESR1 C3

8.69e-051049230250184
Pubmed

Celastrol recruits UBE3A to recognize and degrade the DNA binding domain of steroid receptors.

USP2 ESR1

8.69e-051049236109631
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

RIF1 ZZZ3 ESRRA MED13L

9.18e-0516749420362541
Pubmed

Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.

ESR1 ESRRA

2.02e-041549214701856
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

TPR RIF1 KMT2A

2.48e-048649337253089
Pubmed

A strategy for modulation of enzymes in the ubiquitin system.

USP2 USP48

2.61e-041749223287719
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KMT2A KDM4A

4.01e-042149227626377
Pubmed

A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

ESR1 ESRRA

4.41e-042249223975195
Pubmed

Cartilage-specific overexpression of ERRγ results in Chondrodysplasia and reduced chondrocyte proliferation.

ESR1 ESRRA

4.83e-042349224349082
Pubmed

Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver.

ESR1 ESRRA

5.26e-042449234215813
Pubmed

BMP/SMAD1/5 Signaling in the Endometrial Epithelium Is Essential for Receptivity and Early Pregnancy.

SFRP4 ESR1

5.71e-042549235383354
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

TPR RIF1 ZC3H13 ESRRA KMT2A REXO1

7.38e-0477449615302935
Pubmed

Forkhead box a2 (FOXA2) is essential for uterine function and fertility.

WFDC3 ESR1

9.98e-043349228049832
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KMT2A KDM4A

9.98e-043349226864203
Pubmed

Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets.

SFRP4 EPHB1

1.06e-033449232553152
Pubmed

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.

USP2 RIF1 USP48

1.18e-0314749329576527
Pubmed

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

SLITRK2 ZC3H13 MATN2 KMT2A

1.22e-0333149419490893
CytobandXp11.22

CENPVL2 CENPVL3 CENPVL1

2.73e-0554493Xp11.22
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

ZZZ3 MIB2

4.85e-041833291
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRIG3 SFRP4 MATN2 C3 VIT

1.93e-0618749590a1078b0303799fba5d2ca4fa12076fd75b78b1
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRIG3 SFRP4 MATN2 C3 VIT

1.93e-061874950f90bce2087aecfdbb377e6f46c6e468efbb6e28
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRIG3 SFRP4 MATN2 C3 VIT

1.93e-0618749576c957b2976d38adb45e07bcf96c689442e1fc20
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C3 VIT MOBP EPHB1

3.41e-05167494d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C3 VIT MOBP EPHB1

3.41e-051674947abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SFRP4 C3 MAB21L2 VIT

4.00e-051744941d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYT8 C3 VIT MOBP

4.18e-051764948e7f38de8bf68077e2138f4d06c1f55b0fd096cc
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYT8 C3 VIT MOBP

4.18e-05176494ed575330a08a6748ea4b28433292c8cfd157d444
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SFRP4 ESR1 MATN2 C3

4.27e-051774947af1a19692f7fe8f691178a4e57d62bc379e3d56
ToppCellMesenchymal_cells-Stromal_fibro.|Mesenchymal_cells / Lineage and Cell class

MATN2 CLEC1A VIT RASGRP2

4.66e-05181494f8d914fdc06aaa75a4dc9158daf574ca28fa5432
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

USP2 SFRP4 C3 PLA2G2E

5.07e-05185494d5f5866924648a3c14e2596218fd548a31777aa3
ToppCelldroplet-Kidney-nan-3m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLITRK2 SFRP4 MATN2 PLA2G2E

5.63e-05190494f61e21d53f2f7804ac6e40ab6c7f69838aa94d6a
ToppCelldroplet-Kidney-nan-3m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLITRK2 SFRP4 MATN2 PLA2G2E

5.63e-051904942abeb013bb83c578e67dcb985ba44ca63134950b
ToppCelldroplet-Kidney-nan-3m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLITRK2 SFRP4 MATN2 PLA2G2E

5.74e-05191494d1205aab0937f2becfcd239610e9b78fb8a0c886
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP4 MATN2 C3 VIT

5.86e-05192494853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP4 MATN2 C3 VIT

5.86e-05192494d2c03490c5e835d0f0a732803093c64b8d4b4029
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFRP4 MATN2 C3 VIT

5.86e-05192494cdc652dbfabe41b324fd85c1ed933d29fb73a49f
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFRP4 MATN2 C3 VIT

5.86e-0519249429bee88b45e23f16543ffc7cc361bc5da5d16a2b
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP4 MATN2 C3 VIT

5.86e-0519249449281626ecad0456fdbded2378b7028d7b589686
ToppCelldroplet-Fat-Mat-18m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MATN2 C3 MAB21L2 VIT

5.98e-05193494ebd090d7801480b3cee45caac3d30cc991836769
ToppCelldroplet-Fat-Mat-18m-Mesenchymal-Cd34+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MATN2 C3 MAB21L2 VIT

5.98e-0519349422c58032e58730715224d7934968ce92d150b0e8
ToppCelldroplet-Fat-Mat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MATN2 C3 MAB21L2 VIT

5.98e-05193494573ad2f848bede1fe20c7b4b352a9242ec294725
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SFRP4 ESR1 MATN2 C3

6.10e-05194494c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SFRP4 MATN2 C3 VIT

6.10e-0519449435b30bc954750e939f81a9a7498b8bc2ce69a299
ToppCell(5)_Fibroblasts-(5)_Fibroblast-E|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

SFRP4 MATN2 C3 VIT

6.47e-051974949b1c1d72c5a8c90d71ae31e4c198d2276872eaa0
ToppCellTracheal-NucSeq-Stromal-Mesofibroblastic-Mesothelia|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

WFDC3 SLC26A4 ZBTB8A REXO1

6.47e-05197494e91572edbe48d40269ee2cf7c858764cff6985ac
ToppCellTracheal-NucSeq-Stromal-Mesofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

WFDC3 SLC26A4 ZBTB8A REXO1

6.47e-051974947e3f78a61089d1200cc6b0fa2034bf2998651694
ToppCelldroplet-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Scara5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP4 MATN2 C3 VIT

6.60e-05198494d4f74320ea6c1a7e568ee5bc48bb66cb45e1004d
ToppCell367C-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SFRP4 MATN2 C3 VIT

6.73e-051994942aed8f4a225a3762a5e7ce99aacad9b2a37d61f1
ToppCell367C-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SFRP4 MATN2 C3 VIT

6.73e-05199494c40ca26345753a2197bd9389d7323f7491c1e11d
ToppCell367C-Fibroblasts-Fibroblast-E-|367C / Donor, Lineage, Cell class and subclass (all cells)

SFRP4 MATN2 C3 VIT

6.86e-0520049457b9d6aa2265ab178a5886f36ecc66115bd382a8
ToppCellParenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_adventitial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SFRP4 MATN2 C3 VIT

6.86e-05200494fc3c4778841c4b8bac0afb458352614b2c460617
ToppCellParenchymal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SFRP4 MATN2 C3 VIT

6.86e-0520049436de49593cf6ff1c9229fcceb150c1d68658a360
ToppCell(5)_Fibroblast-E|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

SFRP4 MATN2 C3 VIT

6.86e-0520049475e5ecb05e965e24d569aa2ef5cdf740b1528c06
ToppCell367C-Fibroblasts-Fibroblast-E|367C / Donor, Lineage, Cell class and subclass (all cells)

SFRP4 MATN2 C3 VIT

6.86e-05200494ddfbc004e7bd2fd3f11f046ed8fc049277160547
ToppCelldistal-1-mesenchymal-Adventitial_Fibroblast|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SFRP4 MATN2 C3 VIT

6.86e-05200494738060ed65fa5473fdb39e686f7cdecc059ed92c
ToppCellParenchymal-10x5prime-Stromal-Peri/Epineurial_|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SFRP4 MATN2 C3 VIT

6.86e-052004944c3c11dd5e71ebc3d62264eeaeb71a850b149779
ToppCellTCGA-Head_and_Esophagus-Metastatic|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

CENPVL3 CENPVL1 MOBP

1.82e-0410049374d66f84ff546f4b7354f14a38e5178ee77b5a25
Drug2,2',4,4'-tetrahydroxybenzophenone

ESR1 ESRRA C3

2.95e-0614473ctd:C035476
DrugNalidixic acid sodium salt hydrate; Up 200; 14.6uM; MCF7; HT_HG-U133A

USP2 ESR1 FBXO11 ST3GAL2 ATG2A RASGRP2

3.29e-061994764691_UP
Drugbenzophenone-2

ESR1 ESRRA C3

3.69e-0615473CID000008571
DrugOH-PCB 30

ESR1 ESRRA C3

4.53e-0616473CID000105036
Drug7alpha-methyl-17alpha-ethynylestradiol

ESR1 C3

1.25e-053472ctd:C475050
Drug4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene

ESR1 ESRRA

2.50e-054472ctd:C504750
DrugZK 119010

ESR1 C3

2.50e-054472CID000130936
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A

RIF1 ZZZ3 HJURP FBXO11 MED13L

3.61e-051824753887_DN
DrugDY131

ESR1 ESRRA

4.15e-055472CID000644030
DrugXCT790

ESR1 ESRRA

4.15e-055472CID006918788
DrugCarbarsone [121-59-5]; Down 200; 15.4uM; MCF7; HT_HG-U133A

ESR1 KMT2A FBXO11 ST3GAL2 USP48

4.66e-051924754110_DN
DrugFillalbin [4540-25-4]; Up 200; 13.8uM; PC3; HT_HG-U133A

RIF1 ESR1 ST3GAL2 ATG2A RASGRP2

4.89e-051944754092_UP
DrugGuanadrel sulfate [22195-34-2]; Up 200; 7.6uM; MCF7; HT_HG-U133A

SFRP4 ZC3H13 ESR1 FBXO11 ST3GAL2

5.14e-051964754720_UP
DrugSulfachloropyridazine [80-32-0]; Up 200; 14uM; PC3; HT_HG-U133A

RIF1 ESR1 SLC26A4 ST3GAL2 RASGRP2

5.26e-051974753769_UP
DrugConessine [546-06-5]; Up 200; 11.2uM; HL60; HT_HG-U133A

RIF1 SFRP4 ZC3H13 ESR1 GFER

5.26e-051974752135_UP
DrugIfosfamide [3778-73-2]; Up 200; 15.4uM; MCF7; HT_HG-U133A

RIF1 FBXO11 ST3GAL2 USP48 GFER

5.26e-051974753485_UP
DrugMethantheline bromide [53-46-3]; Up 200; 9.6uM; HL60; HT_HG-U133A

RIF1 SFRP4 ESR1 GFER RASGRP2

5.26e-051974756137_UP
DrugMoxonidine [75438-57-2]; Up 200; 16.6uM; PC3; HT_HG-U133A

USP2 RIF1 ZC3H13 KMT2A RASGRP2

5.65e-052004754084_UP
DrugQuercetine dihydrate [6151-25-3]; Up 200; 11.8uM; PC3; HT_HG-U133A

ZC3H13 SLC26A4 CLEC1A MOBP RASGRP2

5.65e-052004754264_UP
DrugNetilmicin sulfate [56931-57-2]; Up 200; 2.8uM; MCF7; HT_HG-U133A

USP2 KMT2A FBXO11 MOBP RASGRP2

5.65e-052004756005_UP
DrugpSAP

ESR1 ESRRA

6.22e-056472CID000007171
Drugoxybenzone

ESR1 ESRRA GFER

7.15e-0539473CID000004632
DrugDemetric acid

ESR1 ESRRA C3

7.72e-0540473CID000025440
Drugd-equilenin

ESR1 ESRRA C3

8.32e-0541473CID000010597
DrugCI628M

ESR1 ESRRA

8.70e-057472CID003035794
Drug4-hydroxyethynylestradiol

ESR1 ESRRA

1.16e-048472CID000066396
Drug1,3-dibromopropane

RIF1 C3

1.16e-048472CID000008001
Drugo,p'-DDT

ESR1 ESRRA C3

1.42e-0449473CID000013089
DrugZNS 114-666

RIF1 KMT2A EPHB1

1.42e-0449473CID000409441
DrugU23,469

ESR1 ESRRA

1.49e-049472CID000161922
DrugOH-PCB 61

ESR1 C3

1.49e-049472CID000105101
Drugp,p'-hydroxy-DDT

ESR1 ESRRA C3

1.51e-0450473CID000076302
Diseasecryptorchidism (biomarker_via_orthology)

ESR1 GFER

1.35e-0411472DOID:11383 (biomarker_via_orthology)
Diseasemethylcobalamin deficiency type cblE, response to antineoplastic agent

MATN2 KMT2A

1.92e-0413472GO_0097327, MONDO_0009354
Diseasebreast carcinoma (is_implicated_in)

ESR1 FBXO11

7.28e-0425472DOID:3459 (is_implicated_in)
Diseasemacular degeneration (is_implicated_in)

ESR1 C3

8.50e-0427472DOID:4448 (is_implicated_in)
Diseasecerebral white matter volume change measurement, age at assessment

KMT2A VIT

9.14e-0428472EFO_0008007, EFO_0021499
Diseaseprostate cancer (is_marker_for)

ESR1 KMT2A KDM4A

1.98e-03156473DOID:10283 (is_marker_for)
Diseaselung adenocarcinoma, family history of lung cancer

MALRD1 EPHB1

3.01e-0351472EFO_0000571, EFO_0006953
Diseaseleukemia

ESR1 KMT2A

3.49e-0355472C0023418
Diseasecomplement factor H-related protein 1 measurement

CENPVL2 CENPVL3

3.62e-0356472EFO_0600054

Protein segments in the cluster

PeptideGeneStartEntry
KLNKLCRDELCRCAE

C3

1501

P01024
DLRVVDCSCRLCRKK

CENPVL1

151

A0A0U1RR11
QLNCSELKLKRLCCR

ATG2A

1701

Q2TAZ0
ALRDCKNVLDVSCRK

HJURP

336

Q8NCD3
KKCRADRRSCSRCDD

EPHB1

361

P54762
ILREDGKTCRRKDVC

MATN2

556

O00339
VSCSCSRHKLLKRCA

MED13L

421

Q71F56
CHKQCKDRLSVECRR

RASGRP2

536

Q7LDG7
CRCLGDLLDCSRKRL

LRIG3

51

Q6UXM1
IRIRRPCEIKKTDCC

KIAA2026

571

Q5HYC2
KNRRKSCQACRLRKC

ESR1

231

P03372
RIDREKICGRKLECA

PCDHGB1

86

Q9Y5G3
IFCKKRRKRTAGCCV

KDM4A

831

O75164
CRHTRACIEKLRLCD

MALRD1

831

Q5VYJ5
CECDKRAALCFRRNL

PLA2G2E

106

Q9NZK7
DLRVVDCSCRLCRKK

CENPVL2

151

P0DPI3
CECHKCVLILERRRV

DMRTC2

66

Q8IXT2
LLEQDLCRAACVCKR

FBXO11

171

Q86XK2
DLRVVDCSCRLCRKK

CENPVL3

151

A0A0U1RRI6
IGRRCVLKDCCKILD

DCTN5

116

Q9BTE1
CRNKCLSVLKTLRDR

MAB21L2

246

Q9Y586
ARKRCVYTCKIVECR

KMT2A

2061

Q03164
CEITKRRRKACQACR

ESRRA

121

P11474
RRRKACQACRFTKCL

ESRRA

126

P11474
FLSCICCRRRKRSDD

MCOLN2

546

Q8IZK6
TVCEECARRMKKCIR

MIB2

851

Q96AX9
CCCCRRHRKKPRDKE

SYT8

71

Q8NBV8
EEKRPKDSSCRTCCR

REXO1

961

Q8N1G1
KRVCRFCEESRLLLC

TRIM40

76

Q6P9F5
CRNKRIAYKRCITCR

TRIM42

241

Q8IWZ5
KRSRRVRRSKGCDCC

RIF1

1721

Q5UIP0
DDSECITRLCRKRRC

LEAP2

56

Q969E1
SRKTAKDICKIRCLC

SLITRK2

21

Q9H156
SKERLSGKSCACRRC

ST3GAL2

61

Q16842
ICCACQKTRTSRRAK

MOBP

61

Q13875
RCCLCKKLLTKETER

SANBR

326

Q6NSI8
PCEECAEDLRKRLCR

GFER

141

P55789
SKDCKELKRCVCERR

CLEC1A

246

Q8NC01
RKQSCLKRCITDETC

WFDC3

81

Q8IUB2
CKLICRKCKRHVTDL

ZBTB8A

336

Q96BR9
LRESLAKCCSCSRKR

SLC26A4

46

O43511
RMLKDEVSKCVCRCE

TPR

1136

P12270
RRSLGCKRKRECLDE

SPDYE3

191

A6NKU9
LDVDCKRLSPDRCKC

SFRP4

166

Q6FHJ7
KRVCDTDRLACSKTC

VIT

476

Q6UXI7
CCRCRGRKRCIKKFS

USP2

476

O75604
KALCKECVVERCRIL

USP48

551

Q86UV5
KRACRCLILDDCEKR

ZZZ3

161

Q8IYH5
CSCLVVFRVKICRKE

SIGLEC11

576

Q96RL6
CCKALCFRRDSAIRK

ZC3H13

1591

Q5T200
LCICCCKRQKRTKIR

KIAA0319

976

Q5VV43