Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

JAG2 MMRN1 EYS FBN1 FBN2 NOTCH2NLB DLL4 FAT3 LRP1 LRP2 FLG2 DLL1 SLC25A23 NOTCH2 NOTCH3 CRB1

9.63e-127494816GO:0005509
GeneOntologyMolecularFunctionextracellular matrix structural constituent

MMRN1 FBN1 FBN2 MUC17 TFPI2 PAPLN TECTA

3.12e-07188487GO:0005201
GeneOntologyMolecularFunctionNotch binding

JAG2 NOTCH2NLB DLL4 DLL1

4.95e-0727484GO:0005112
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

MMRN1 FBN1 FBN2

2.82e-0612483GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

MMRN1 FBN1 FBN2

4.66e-0614483GO:0097493
GeneOntologyMolecularFunctionstructural molecule activity

MMRN1 KRT26 FBN1 FBN2 MUC17 RPS2 TFPI2 OBSCN PAPLN FLG2 TECTA

6.51e-068914811GO:0005198
GeneOntologyMolecularFunctionsignaling receptor regulator activity

JAG2 FBN1 FBN2 DLL4 REG1B CCN2 LYNX1 DLL1

9.95e-05616488GO:0030545
GeneOntologyMolecularFunctionarachidonate-CoA ligase activity

ACSL6 ACSL5

3.07e-0411482GO:0047676
GeneOntologyMolecularFunctionreceptor ligand activity

JAG2 FBN1 FBN2 DLL4 REG1B CCN2 DLL1

3.10e-04547487GO:0048018
GeneOntologyMolecularFunctionsignaling receptor activator activity

JAG2 FBN1 FBN2 DLL4 REG1B CCN2 DLL1

3.34e-04554487GO:0030546
GeneOntologyMolecularFunctioncell adhesion molecule binding

FBN1 RPS2 OBSCN CCN2 ADAM2 ITGAL NOTCH3

5.34e-04599487GO:0050839
GeneOntologyMolecularFunctionlong-chain fatty acid-CoA ligase activity

ACSL6 ACSL5

5.82e-0415482GO:0004467
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP1 LRP2

6.65e-0416482GO:0005041
GeneOntologyMolecularFunctionintegrin binding

FBN1 CCN2 ADAM2 ITGAL

8.21e-04175484GO:0005178
GeneOntologyMolecularFunctioninsulin-like growth factor binding

LRP2 CCN2

9.43e-0419482GO:0005520
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP1 LRP2

1.15e-0321482GO:0030228
GeneOntologyMolecularFunctionfatty acid ligase activity

ACSL6 ACSL5

1.77e-0326482GO:0015645
GeneOntologyMolecularFunctionCoA-ligase activity

ACSL6 ACSL5

1.91e-0327482GO:0016405
GeneOntologyMolecularFunctionserine-type endopeptidase inhibitor activity

CRIM1 TFPI2 PAPLN

2.06e-03105483GO:0004867
GeneOntologyMolecularFunctionacid-thiol ligase activity

ACSL6 ACSL5

2.52e-0331482GO:0016878
GeneOntologyMolecularFunctionPDZ domain binding

CRIM1 MUC17 LRP2

3.22e-03123483GO:0030165
GeneOntologyMolecularFunctionlipoprotein particle receptor binding

LRP1 LRP2

3.96e-0339482GO:0070325
GeneOntologyMolecularFunctionligase activity, forming carbon-sulfur bonds

ACSL6 ACSL5

4.37e-0341482GO:0016877
GeneOntologyBiologicalProcessartery morphogenesis

DLL4 KAT6A LRP1 LRP2 NOTCH3

2.58e-0692495GO:0048844
GeneOntologyBiologicalProcesspositive regulation of Notch signaling pathway

JAG2 NOTCH2NLB DLL4 DLL1

7.55e-0653494GO:0045747
GeneOntologyBiologicalProcessNotch signaling pathway

JAG2 NOTCH2NLB DLL4 DLL1 NOTCH2 NOTCH3

1.01e-05210496GO:0007219
GeneOntologyBiologicalProcessartery development

DLL4 KAT6A LRP1 LRP2 NOTCH3

1.57e-05133495GO:0060840
GeneOntologyBiologicalProcesspositive regulation of long-chain fatty acid import across plasma membrane

ACSL6 ACSL5

1.66e-053492GO:0010747
GeneOntologyBiologicalProcessanimal organ morphogenesis

JAG2 FBN2 DLL4 FAT3 KAT6A PKHD1 LRP2 CCN2 TECTA DLL1 NOTCH2 CRB1

3.07e-0512694912GO:0009887
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2

3.31e-054492GO:0035583
GeneOntologyBiologicalProcesspositive regulation of long-chain fatty acid import into cell

ACSL6 ACSL5

3.31e-054492GO:0140214
GeneOntologyBiologicalProcessaorta development

DLL4 KAT6A LRP1 LRP2

3.89e-0580494GO:0035904
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

FBN1 FBN2 CRIM1 LRP1 LRP2 DLL1 NOTCH2

5.02e-05412497GO:0090287
GeneOntologyBiologicalProcesspositive regulation of lysosomal protein catabolic process

LRP1 LRP2

5.50e-055492GO:1905167
GeneOntologyBiologicalProcesschemoattraction of axon

LRP1 LRP2

5.50e-055492GO:0061642
GeneOntologyBiologicalProcessneuron fate commitment

JAG2 DLL4 DLL1 NOTCH3

6.45e-0591494GO:0048663
GeneOntologyBiologicalProcessinner ear receptor cell fate commitment

JAG2 DLL1

8.24e-056492GO:0060120
GeneOntologyBiologicalProcessglomerulus vasculature morphogenesis

NOTCH2 NOTCH3

8.24e-056492GO:0072103
GeneOntologyBiologicalProcessglomerular capillary formation

NOTCH2 NOTCH3

8.24e-056492GO:0072104
GeneOntologyBiologicalProcessauditory receptor cell fate commitment

JAG2 DLL1

8.24e-056492GO:0009912
GeneOntologyBiologicalProcesspositive regulation of cell population proliferation

TBC1D8 DLL4 PKHD1 LRP2 MARCHF7 REG1B CCN2 DLL1 ITGAL NOTCH2 NOTCH3

8.62e-0511904911GO:0008284
GeneOntologyBiologicalProcesspositive regulation of lipid transport

ACSL6 ABCA13 LRP1 ACSL5

1.01e-04102494GO:0032370
GeneOntologyBiologicalProcessrenal system vasculature morphogenesis

NOTCH2 NOTCH3

1.15e-047492GO:0061438
GeneOntologyBiologicalProcesskidney vasculature morphogenesis

NOTCH2 NOTCH3

1.15e-047492GO:0061439
GeneOntologyBiologicalProcesspositive regulation of protein catabolic process in the vacuole

LRP1 LRP2

1.15e-047492GO:1904352
GeneOntologyBiologicalProcessregulation of long-chain fatty acid import across plasma membrane

ACSL6 ACSL5

1.15e-047492GO:0010746
GeneOntologyBiologicalProcessaorta morphogenesis

DLL4 KAT6A LRP1

1.26e-0441493GO:0035909
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

FBN1 FBN2 CRIM1 DLL4 LRP1 LRP2 CCN2 DLL1 NOTCH2

1.53e-04850499GO:0071363
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 FBN2

1.53e-048492GO:0071694
GeneOntologyBiologicalProcessregulation of Notch signaling pathway

JAG2 NOTCH2NLB DLL4 DLL1

1.55e-04114494GO:0008593
GeneOntologyBiologicalProcessnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

FBN1 FBN2 CRIM1 LRP1 LRP2

1.65e-04218495GO:0090101
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

FBN1 FBN2 CRIM1 LRP1 LRP2 NOTCH2

1.65e-04347496GO:0090092
GeneOntologyBiologicalProcessregulation of long-chain fatty acid import into cell

ACSL6 ACSL5

1.97e-049492GO:0140212
GeneOntologyBiologicalProcessresponse to growth factor

FBN1 FBN2 CRIM1 DLL4 LRP1 LRP2 CCN2 DLL1 NOTCH2

2.04e-04883499GO:0070848
GeneOntologyBiologicalProcesscell fate determination

JAG2 DLL1 NOTCH2

2.28e-0450493GO:0001709
GeneOntologyBiologicalProcesskidney development

FBN1 PKHD1 LRP2 DLL1 NOTCH2 NOTCH3

2.40e-04372496GO:0001822
GeneOntologyBiologicalProcessmarginal zone B cell differentiation

DLL1 NOTCH2

2.46e-0410492GO:0002315
GeneOntologyBiologicalProcessproximal tubule development

DLL1 NOTCH2

2.46e-0410492GO:0072014
GeneOntologyBiologicalProcesscholangiocyte proliferation

PKHD1 NOTCH2

2.46e-0410492GO:1990705
GeneOntologyBiologicalProcesspositive regulation of lipid localization

ACSL6 ABCA13 LRP1 ACSL5

2.49e-04129494GO:1905954
GeneOntologyBiologicalProcessregulation of BMP signaling pathway

FBN1 CRIM1 LRP2 NOTCH2

2.64e-04131494GO:0030510
GeneOntologyBiologicalProcessrenal system development

FBN1 PKHD1 LRP2 DLL1 NOTCH2 NOTCH3

2.93e-04386496GO:0072001
GeneOntologyBiologicalProcessglomerulus morphogenesis

NOTCH2 NOTCH3

3.00e-0411492GO:0072102
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

FBN1 FBN2

3.00e-0411492GO:0035581
GeneOntologyBiologicalProcessregulation of lysosomal protein catabolic process

LRP1 LRP2

3.59e-0412492GO:1905165
GeneOntologyBiologicalProcesslong-chain fatty acid import across plasma membrane

ACSL6 ACSL5

3.59e-0412492GO:0015911
GeneOntologyBiologicalProcessheart development

DHX36 FBN1 DLL4 KAT6A LRP1 LRP2 DLL1 NOTCH2

3.77e-04757498GO:0007507
GeneOntologyBiologicalProcesscell morphogenesis

DHX36 FAT3 PKHD1 LRP1 LRP2 REG1B TECTA NOTCH2 NOTCH3 CRB1

4.22e-0411944910GO:0000902
GeneOntologyBiologicalProcessregulation of osteoclast development

FBN1 NOTCH2

4.24e-0413492GO:2001204
GeneOntologyBiologicalProcessextracellular regulation of signal transduction

FBN1 FBN2

4.24e-0413492GO:1900115
GeneOntologyBiologicalProcessextracellular negative regulation of signal transduction

FBN1 FBN2

4.24e-0413492GO:1900116
GeneOntologyBiologicalProcesscell-matrix adhesion

PKHD1 LRP1 CCN2 TECTA ITGAL

4.41e-04270495GO:0007160
GeneOntologyBiologicalProcessregulation of protein catabolic process in the vacuole

LRP1 LRP2

4.94e-0414492GO:1904350
GeneOntologyBiologicalProcessleft/right axis specification

DLL1 NOTCH2

4.94e-0414492GO:0070986
GeneOntologyBiologicalProcessinner ear auditory receptor cell differentiation

JAG2 TECTA DLL1

5.42e-0467493GO:0042491
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

JAG2 DLL4 PKHD1 LRP2 FLG2 DLL1 NOTCH2

6.09e-04619497GO:0002009
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

FBN1 FBN2 CRIM1 LRP1 LRP2 NOTCH2

6.22e-04445496GO:0141091
GeneOntologyBiologicalProcessblood vessel morphogenesis

DLL4 KAT6A LRP1 LRP2 CCN2 DLL1 NOTCH2 NOTCH3

6.25e-04817498GO:0048514
GeneOntologyBiologicalProcesscamera-type eye morphogenesis

FAT3 DLL1 NOTCH2 CRB1

7.22e-04171494GO:0048593
GeneOntologyBiologicalProcesshair cell differentiation

JAG2 TECTA DLL1

8.46e-0478493GO:0035315
GeneOntologyBiologicalProcessregulation of lipid transport

ACSL6 ABCA13 LRP1 ACSL5

8.57e-04179494GO:0032368
GeneOntologyBiologicalProcesspositive regulation of neural precursor cell proliferation

DLL4 LRP2 NOTCH2

9.10e-0480493GO:2000179
GeneOntologyBiologicalProcessnegative regulation of BMP signaling pathway

FBN1 CRIM1 LRP2

9.10e-0480493GO:0030514
GeneOntologyBiologicalProcesslong-chain fatty-acyl-CoA biosynthetic process

ACSL6 ACSL5

9.21e-0419492GO:0035338
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

FBN1 FBN2 CRIM1 LRP1 LRP2 NOTCH2

9.42e-04482496GO:0007178
GeneOntologyBiologicalProcessheart morphogenesis

DLL4 KAT6A LRP2 DLL1 NOTCH2

9.63e-04321495GO:0003007
GeneOntologyBiologicalProcesslong-chain fatty acid import into cell

ACSL6 ACSL5

1.02e-0320492GO:0044539
GeneOntologyBiologicalProcesstransport across blood-brain barrier

SLC8A2 LRP1 LRP2

1.16e-0387493GO:0150104
GeneOntologyBiologicalProcessblood vessel remodeling

DLL4 LRP1 CRB1

1.16e-0387493GO:0001974
GeneOntologyBiologicalProcesstube morphogenesis

DLL4 KAT6A PKHD1 LRP1 LRP2 CCN2 DLL1 NOTCH2 NOTCH3

1.18e-031125499GO:0035239
GeneOntologyBiologicalProcessvascular transport

SLC8A2 LRP1 LRP2

1.20e-0388493GO:0010232
GeneOntologyBiologicalProcesscell fate commitment

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

1.21e-03338495GO:0045165
GeneOntologyBiologicalProcessBMP signaling pathway

FBN1 CRIM1 LRP2 NOTCH2

1.22e-03197494GO:0030509
GeneOntologyBiologicalProcessosteoclast development

FBN1 NOTCH2

1.24e-0322492GO:0036035
GeneOntologyBiologicalProcessbone cell development

FBN1 NOTCH2

1.24e-0322492GO:0098751
GeneOntologyBiologicalProcessfatty acid transmembrane transport

ACSL6 ACSL5

1.24e-0322492GO:1902001
GeneOntologyBiologicalProcessretina morphogenesis in camera-type eye

FAT3 DLL1 CRB1

1.28e-0390493GO:0060042
GeneOntologyBiologicalProcesssensory organ morphogenesis

FAT3 TECTA DLL1 NOTCH2 CRB1

1.29e-03343495GO:0090596
GeneOntologyBiologicalProcesscell adhesion mediated by integrin

MMRN1 FBN1 ITGAL

1.32e-0391493GO:0033627
GeneOntologyBiologicalProcessregulation of neurogenesis

DHX36 DLL4 LRP1 LRP2 DLL1 NOTCH2

1.32e-03515496GO:0050767
GeneOntologyBiologicalProcessnegative regulation of cilium assembly

MARCHF7 MPHOSPH9

1.35e-0323492GO:1902018
GeneOntologyBiologicalProcesseye morphogenesis

FAT3 DLL1 NOTCH2 CRB1

1.39e-03204494GO:0048592
GeneOntologyBiologicalProcessembryonic morphogenesis

JAG2 FBN2 DLL4 LRP2 TECTA DLL1 NOTCH2

1.39e-03713497GO:0048598
GeneOntologyBiologicalProcessblood vessel development

DLL4 KAT6A LRP1 LRP2 CCN2 DLL1 NOTCH2 NOTCH3

1.43e-03929498GO:0001568
GeneOntologyBiologicalProcesstube development

FBN1 DLL4 KAT6A PKHD1 LRP1 LRP2 CCN2 DLL1 NOTCH2 NOTCH3

1.46e-0314024910GO:0035295
GeneOntologyBiologicalProcesslysosomal protein catabolic process

LRP1 LRP2

1.48e-0324492GO:1905146
GeneOntologyBiologicalProcesstranscytosis

LRP1 LRP2

1.48e-0324492GO:0045056
GeneOntologyBiologicalProcessinner ear receptor cell differentiation

JAG2 TECTA DLL1

1.54e-0396493GO:0060113
GeneOntologyBiologicalProcessretina development in camera-type eye

DLL4 FAT3 DLL1 CRB1

1.57e-03211494GO:0060041
GeneOntologyBiologicalProcesssensory organ development

JAG2 DLL4 FAT3 TECTA DLL1 NOTCH2 CRB1

1.59e-03730497GO:0007423
GeneOntologyBiologicalProcesscardiac chamber development

DLL4 LRP1 LRP2 NOTCH2

1.60e-03212494GO:0003205
GeneOntologyBiologicalProcesslipid import into cell

ACSL6 ACSL5

1.60e-0325492GO:0140354
GeneOntologyBiologicalProcessretina layer formation

FAT3 CRB1

1.60e-0325492GO:0010842
GeneOntologyBiologicalProcessdetection of light stimulus involved in visual perception

EYS CRB1

1.60e-0325492GO:0050908
GeneOntologyBiologicalProcessdetection of light stimulus involved in sensory perception

EYS CRB1

1.60e-0325492GO:0050962
GeneOntologyBiologicalProcesspositive regulation of endocytosis

ABCA13 LRP1 LRP2 DLL1

1.63e-03213494GO:0045807
GeneOntologyBiologicalProcessregulation of lipid localization

ACSL6 ABCA13 LRP1 ACSL5

1.68e-03215494GO:1905952
GeneOntologyBiologicalProcessresponse to BMP

FBN1 CRIM1 LRP2 NOTCH2

1.68e-03215494GO:0071772
GeneOntologyBiologicalProcesscellular response to BMP stimulus

FBN1 CRIM1 LRP2 NOTCH2

1.68e-03215494GO:0071773
GeneOntologyBiologicalProcesscirculatory system development

DHX36 FBN1 DLL4 KAT6A LRP1 LRP2 CCN2 DLL1 NOTCH2 NOTCH3

1.80e-0314424910GO:0072359
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

DHX36 FAT3 LRP1 LRP2 TECTA NOTCH2 NOTCH3

1.83e-03748497GO:0048667
GeneOntologyBiologicalProcessneural retina development

DLL4 FAT3 CRB1

1.83e-03102493GO:0003407
GeneOntologyBiologicalProcesstissue morphogenesis

JAG2 DLL4 PKHD1 LRP2 FLG2 DLL1 NOTCH2

1.86e-03750497GO:0048729
GeneOntologyCellularComponentextracellular matrix

MMRN1 LAMB4 EYS FBN1 FBN2 ADAMTS4 MUC17 TFPI2 PAPLN LINGO3 REG1B CCN2 TECTA

2.36e-096564913GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

MMRN1 LAMB4 EYS FBN1 FBN2 ADAMTS4 MUC17 TFPI2 PAPLN LINGO3 REG1B CCN2 TECTA

2.45e-096584913GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

MMRN1 LAMB4 EYS FBN1 FBN2 ADAMTS4 MUC17 PAPLN REG1B CCN2

3.41e-075304910GO:0062023
GeneOntologyCellularComponentmicrofibril

FBN1 FBN2

4.13e-0413492GO:0001527
HumanPhenoOliguria

OBSCN PKHD1 CCN2

2.90e-0517193HP:0100520
HumanPhenoAbnormal upper to lower segment ratio

FBN1 FBN2

3.95e-053192HP:0012772
MousePhenoabnormal capillary morphology

CRIM1 DLL4 PKHD1 DLL1 NOTCH2

6.40e-0693405MP:0003658
MousePhenoabnormal aorta morphology

FBN1 CRIM1 DLL4 KAT6A LRP2 DLL1

3.95e-05225406MP:0000272
MousePhenoabnormal vertebrae morphology

JAG2 FBN1 FBN2 CRIM1 KAT6A CCN2 DLL1 NOTCH2

1.31e-04546408MP:0000137
MousePhenoperinatal lethality, complete penetrance

JAG2 CRIM1 ZNRF3 KAT6A LRP1 LRP2 CCN2 DLL1 NOTCH2

1.44e-04712409MP:0011089
MousePhenoabnormal systemic artery morphology

FBN1 CRIM1 DLL4 KAT6A LRP2 DLL1

2.07e-04304406MP:0011655
MousePhenoabnormal artery morphology

FBN1 CRIM1 DLL4 KAT6A LRP2 DLL1 NOTCH3

2.21e-04440407MP:0002191
MousePhenoincreased kidney apoptosis

CRIM1 PKHD1 NOTCH2

2.47e-0443403MP:0011368
MousePhenodecreased kidney cell proliferation

PKHD1 NOTCH2

2.84e-049402MP:0011441
MousePhenoabnormal vertebral column morphology

JAG2 FBN1 FBN2 CRIM1 KAT6A CCN2 DLL1 NOTCH2 NOTCH3

3.06e-04787409MP:0004703
MousePhenoabnormal glomerular capillary morphology

CRIM1 PKHD1 NOTCH2

3.23e-0447403MP:0011320
MousePhenoabnormal kidney capillary morphology

CRIM1 PKHD1 NOTCH2

3.43e-0448403MP:0011310
MousePhenodecreased bone mineral density

PCNX2 FBN1 CCN2 DLL1 NOTCH2 NOTCH3 ACSL5

3.57e-04476407MP:0000063
DomainEGF-type_Asp/Asn_hydroxyl_site

JAG2 MMRN1 EYS FBN1 FBN2 DLL4 FAT3 LRP1 LRP2 DLL1 NOTCH2 NOTCH3 CRB1

4.85e-191064813IPR000152
DomainEGF_1

JAG2 MMRN1 LAMB4 EYS FBN1 FBN2 DLL4 MUC17 FAT3 LRP1 LRP2 ADAM2 DLL1 NOTCH2 NOTCH3 CRB1

1.39e-182554816PS00022
DomainEGF_2

JAG2 MMRN1 LAMB4 EYS FBN1 FBN2 DLL4 MUC17 FAT3 LRP1 LRP2 ADAM2 DLL1 NOTCH2 NOTCH3 CRB1

2.57e-182654816PS01186
DomainEGF_CA

JAG2 MMRN1 EYS FBN1 FBN2 DLL4 FAT3 LRP1 LRP2 DLL1 NOTCH2 NOTCH3 CRB1

3.25e-181224813SM00179
DomainEGF-like_Ca-bd_dom

JAG2 MMRN1 EYS FBN1 FBN2 DLL4 FAT3 LRP1 LRP2 DLL1 NOTCH2 NOTCH3 CRB1

4.05e-181244813IPR001881
DomainEGF_3

JAG2 MMRN1 EYS FBN1 FBN2 DLL4 MUC17 FAT3 LRP1 LRP2 ADAM2 DLL1 NOTCH2 NOTCH3 CRB1

1.51e-172354815PS50026
DomainEGF

JAG2 MMRN1 EYS FBN1 FBN2 DLL4 MUC17 FAT3 LRP1 LRP2 TECTA DLL1 NOTCH2 NOTCH3 CRB1

1.51e-172354815SM00181
DomainASX_HYDROXYL

JAG2 EYS FBN1 FBN2 DLL4 FAT3 LRP1 LRP2 DLL1 NOTCH2 NOTCH3 CRB1

1.67e-171004812PS00010
DomainEGF-like_dom

JAG2 MMRN1 EYS FBN1 FBN2 DLL4 MUC17 FAT3 LRP1 LRP2 TECTA DLL1 NOTCH2 NOTCH3 CRB1

3.62e-172494815IPR000742
DomainEGF-like_CS

JAG2 MMRN1 LAMB4 EYS FBN1 FBN2 DLL4 MUC17 FAT3 LRP1 LRP2 DLL1 NOTCH2 NOTCH3 CRB1

7.33e-172614815IPR013032
DomainGrowth_fac_rcpt_

JAG2 EYS FBN1 FBN2 CRIM1 DLL4 LRP1 LRP2 CCN2 DLL1 NOTCH2 NOTCH3 CRB1

8.69e-171564813IPR009030
DomainEGF_Ca-bd_CS

JAG2 EYS FBN1 FBN2 FAT3 LRP1 LRP2 DLL1 NOTCH2 NOTCH3 CRB1

7.97e-16974811IPR018097
DomainEGF_CA

JAG2 EYS FBN1 FBN2 FAT3 LRP1 LRP2 DLL1 NOTCH2 NOTCH3 CRB1

1.01e-15994811PS01187
DomainEGF

JAG2 MMRN1 EYS DLL4 LRP1 LRP2 TECTA DLL1 NOTCH2 NOTCH3 CRB1

1.54e-141264811PF00008
DomainhEGF

JAG2 EYS FBN2 DLL1 NOTCH2 NOTCH3 CRB1

5.33e-1328487PF12661
DomainEGF_CA

JAG2 FBN1 FBN2 FAT3 LRP1 LRP2 NOTCH2 NOTCH3

4.71e-1186488PF07645
DomainDSL

JAG2 DLL4 DLL1

6.36e-084483PF01414
DomainDSL

JAG2 DLL4 DLL1

6.36e-084483SM00051
DomainDSL

JAG2 DLL4 DLL1

1.59e-075483IPR001774
DomainDSL

JAG2 DLL4 DLL1

1.59e-075483PS51051
DomainNotch_ligand_N

JAG2 DLL4 DLL1

1.59e-075483IPR011651
DomainMNNL

JAG2 DLL4 DLL1

1.59e-075483PF07657
DomaincEGF

FBN1 FBN2 LRP1 LRP2

5.51e-0726484IPR026823
DomaincEGF

FBN1 FBN2 LRP1 LRP2

5.51e-0726484PF12662
DomainVWC

JAG2 CRIM1 CCN2 TECTA

2.66e-0638484SM00214
DomainVWFC_2

JAG2 CRIM1 CCN2 TECTA

2.66e-0638484PS50184
DomainVWF_dom

JAG2 CRIM1 CCN2 TECTA

4.00e-0642484IPR001007
DomainVWC_out

JAG2 CRIM1 TECTA

1.50e-0519483SM00215
DomainEGF_extracell

JAG2 DLL4 LRP2 NOTCH3

1.68e-0560484IPR013111
DomainEGF_2

JAG2 DLL4 LRP2 NOTCH3

1.68e-0560484PF07974
DomainDUF3454

NOTCH2 NOTCH3

1.94e-053482PF11936
DomainDUF3454_notch

NOTCH2 NOTCH3

1.94e-053482IPR024600
DomainDUF3454

NOTCH2 NOTCH3

1.94e-053482SM01334
DomainFBN

FBN1 FBN2

1.94e-053482IPR011398
DomainNotch

NOTCH2 NOTCH3

3.87e-054482IPR008297
DomainNODP

NOTCH2 NOTCH3

3.87e-054482PF07684
DomainNotch_NODP_dom

NOTCH2 NOTCH3

3.87e-054482IPR011656
DomainNotch_NOD_dom

NOTCH2 NOTCH3

3.87e-054482IPR010660
DomainNOD

NOTCH2 NOTCH3

3.87e-054482PF06816
DomainNOD

NOTCH2 NOTCH3

3.87e-054482SM01338
DomainNODP

NOTCH2 NOTCH3

3.87e-054482SM01339
DomainLNR

NOTCH2 NOTCH3

6.44e-055482PS50258
DomainVWFC_1

JAG2 CRIM1 CCN2

1.07e-0436483PS01208
DomainLAM_G_DOMAIN

EYS FAT3 CRB1

1.26e-0438483PS50025
DomainTB

FBN1 FBN2

1.35e-047482PF00683
DomainNotch_dom

NOTCH2 NOTCH3

1.35e-047482IPR000800
DomainNotch

NOTCH2 NOTCH3

1.35e-047482PF00066
DomainNL

NOTCH2 NOTCH3

1.35e-047482SM00004
DomainLaminin_G_2

EYS FAT3 CRB1

1.47e-0440483PF02210
Domain-

FBN1 FBN2

1.79e-0484823.90.290.10
DomainLamG

EYS FAT3 CRB1

1.96e-0444483SM00282
DomainTB

FBN1 FBN2

2.30e-049482PS51364
DomainTB_dom

FBN1 FBN2

2.30e-049482IPR017878
DomainLaminin_G

EYS FAT3 CRB1

4.45e-0458483IPR001791
DomainTSP_1

ADAMTS4 PAPLN CCN2

5.68e-0463483PF00090
DomainTIL_dom

LRP2 TECTA

5.77e-0414482IPR002919
DomainLdl_recept_b

LRP1 LRP2

5.77e-0414482PF00058
DomainLDLRB

LRP1 LRP2

5.77e-0414482PS51120
DomainTSP1

ADAMTS4 PAPLN CCN2

6.22e-0465483SM00209
DomainTSP1_rpt

ADAMTS4 PAPLN CCN2

6.22e-0465483IPR000884
DomainTSP1

ADAMTS4 PAPLN CCN2

6.22e-0465483PS50092
DomainLY

LRP1 LRP2

6.65e-0415482SM00135
DomainLDLR_classB_rpt

LRP1 LRP2

6.65e-0415482IPR000033
Domain-

TFPI2 PAPLN

9.64e-04184824.10.410.10
DomainPrtase_inh_Kunz-CS

TFPI2 PAPLN

9.64e-0418482IPR020901
DomainIB

CRIM1 CCN2

9.64e-0418482SM00121
DomainKU

TFPI2 PAPLN

9.64e-0418482SM00131
DomainBPTI_KUNITZ_2

TFPI2 PAPLN

1.08e-0319482PS50279
DomainKunitz_BPTI

TFPI2 PAPLN

1.08e-0319482PF00014
DomainBPTI_KUNITZ_1

TFPI2 PAPLN

1.08e-0319482PS00280
DomainIGFBP-like

CRIM1 CCN2

1.19e-0320482IPR000867
DomainIGFBP

CRIM1 CCN2

1.19e-0320482PF00219
DomainIGFBP_N_2

CRIM1 CCN2

1.19e-0320482PS51323
DomainADAM_spacer1

ADAMTS4 PAPLN

1.58e-0323482IPR010294
DomainADAM_spacer1

ADAMTS4 PAPLN

1.58e-0323482PF05986
DomainKunitz_BPTI

TFPI2 PAPLN

1.58e-0323482IPR002223
DomainPeptidase_M12B_ADAM-TS

ADAMTS4 PAPLN

1.72e-0324482IPR013273
Domain-

EYS FAT3 CRB1

1.87e-03954832.60.120.200
DomainAMP-binding_CS

ACSL6 ACSL5

2.02e-0326482IPR020845
DomainACR

ADAMTS4 ADAM2

2.18e-0327482SM00608
DomainADAM_Cys-rich

ADAMTS4 ADAM2

2.18e-0327482IPR006586
DomainAMP_BINDING

ACSL6 ACSL5

2.34e-0328482PS00455
DomainVWC

CRIM1 CCN2

2.34e-0328482PF00093
DomainConA-like_dom

MMRN1 EYS FAT3 CRB1

2.39e-03219484IPR013320
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

8.88e-1113355M47423
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

5.44e-0927355M39545
PathwayWP_NOTCH_SIGNALING_WP268

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

7.97e-0845355M39571
PathwayWP_NOTCH_SIGNALING_PATHWAY

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

8.92e-0846355MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

9.97e-0847355M7946
PathwayREACTOME_SIGNALING_BY_NOTCH3

JAG2 DLL4 DLL1 NOTCH3

1.20e-0719354MM15594
PathwayREACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

JAG2 DLL4 DLL1 NOTCH2

2.26e-0722354M27210
PathwayPID_NOTCH_PATHWAY

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

3.19e-0759355M17
PathwayWP_NOTCH_SIGNALING_WP61

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

3.77e-0761355M39540
PathwayREACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

JAG2 DLL4 DLL1 NOTCH3

3.88e-0725354M27879
PathwayREACTOME_SIGNALING_BY_NOTCH1_T_7_9_NOTCH1_M1580_K2555_TRANSLOCATION_MUTANT

JAG2 DLL4 DLL1

4.87e-077353M27199
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_LIGAND_UBIQUITYLATION

JAG2 DLL4 DLL1

1.17e-069353M47866
PathwayREACTOME_SIGNALING_BY_NOTCH2

JAG2 DLL4 DLL1 NOTCH2

1.24e-0633354M604
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

1.67e-0682355MM15922
PathwayREACTOME_SIGNALING_BY_NOTCH

JAG2 DLL4 DLL1 NOTCH3

2.46e-0639354MM14604
PathwayREACTOME_SIGNALING_BY_NOTCH3

JAG2 DLL4 DLL1 NOTCH3

6.23e-0649354M618
PathwayREACTOME_SIGNALING_BY_NOTCH1_HD_DOMAIN_MUTANTS_IN_CANCER

JAG2 DLL4 DLL1

6.25e-0615353M27202
PathwayKEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY

JAG2 DLL4 DLL1

7.68e-0616353M47424
PathwayWP_NOTCH1_REGULATION_OF_ENDOTHELIAL_CELL_CALCIFICATION

JAG2 DLL4 DLL1

9.31e-0617353M39389
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

1.00e-05118355M39852
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS4 MUC17 NOTCH2 NOTCH3

2.32e-0568354M27303
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FBN1 FBN2 CCN2

3.11e-0525353M39713
PathwayWP_BREAST_CANCER_PATHWAY

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

3.63e-05154355M39739
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

4.49e-05161355M39770
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH2 NOTCH3

5.96e-055352M27411
PathwayREACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS

JAG2 DLL4 DLL1

6.01e-0531353M592
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH2 NOTCH3

8.93e-056352M27068
PathwayWP_NEURAL_CREST_DIFFERENTIATION

DLL4 DLL1 NOTCH2 NOTCH3

9.36e-0597354MM15926
PathwayWP_NEURAL_CREST_DIFFERENTIATION

DLL4 DLL1 NOTCH2 NOTCH3

1.10e-04101354M39448
PathwayKEGG_MEDICUS_ENV_FACTOR_E2_TO_NUCLEAR_INITIATED_ESTROGEN_SIGNALING_PATHWAY

DLL4 DLL1

1.25e-047352M47805
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH2 NOTCH3

3.25e-0411352M47865
PathwayKEGG_MEDICUS_REFERENCE_BETA_OXIDATION_ACYL_COA_SYNTHESIS

ACSL6 ACSL5

3.25e-0411352M47626
PathwayREACTOME_SIGNALING_BY_NOTCH

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

3.29e-04246355M10189
PathwayBIOCARTA_HES_PATHWAY

DLL1 NOTCH2

3.89e-0412352MM1562
PathwayBIOCARTA_HES_PATHWAY

DLL1 NOTCH2

3.89e-0412352M22042
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH2 NOTCH3

3.89e-0412352M47532
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH2 NOTCH3

3.89e-0412352M47533
PathwayREACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER

JAG2 DLL4 DLL1

3.94e-0458353M29616
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS4 MUC17 NOTCH2 NOTCH3

4.16e-04143354M27275
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NOTCH2 NOTCH3

4.59e-0413352M47534
PathwayREACTOME_SIGNALING_BY_NOTCH1

JAG2 DLL4 DLL1

8.05e-0474353M616
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH2 NOTCH3

8.94e-0418352M614
PathwayWP_FATTY_ACID_TRANSPORTERS

ACSL6 ACSL5

8.94e-0418352M42570
PathwayWP_FATTY_ACID_BIOSYNTHESIS

ACSL6 ACSL5

1.34e-0322352M39440
PathwayREACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS

ACSL6 ACSL5

1.34e-0322352MM15451
PathwayWP_CANCER_PATHWAYS

JAG2 LAMB4 DLL4 DLL1 NOTCH2 NOTCH3

1.40e-03507356M48302
PathwayWP_FATTY_ACID_BIOSYNTHESIS

ACSL6 ACSL5

1.47e-0323352MM15885
PathwayREACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS

ACSL6 ACSL5

1.60e-0324352M1016
PathwayKEGG_DORSO_VENTRAL_AXIS_FORMATION

NOTCH2 NOTCH3

1.60e-0324352M11190
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

NOTCH2 NOTCH3

2.17e-0328352M6177
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

FBN1 FBN2 ADAMTS4

2.79e-03114353MM14571
PathwayREACTOME_FATTY_ACYL_COA_BIOSYNTHESIS

ACSL6 ACSL5

2.83e-0332352MM15446
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 FBN2

2.83e-0332352MM14854
PathwayWP_FATTY_ACID_BETAOXIDATION

ACSL6 ACSL5

3.20e-0334352M39596
PathwayWP_FATTY_ACID_BETAOXIDATION

ACSL6 ACSL5

3.20e-0334352MM15937
PathwayWP_OSX_AND_MIRNAS_IN_TOOTH_DEVELOPMENT

NOTCH2 NOTCH3

3.20e-0334352M39390
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTS4 MUC17 NOTCH2 NOTCH3

3.28e-03250354M27554
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

FBN1 FBN2 ADAMTS4 ITGAL

3.67e-03258354MM14572
PathwayWP_NEOVASCULARIZATION_PROCESSES

DLL4 NOTCH3

3.78e-0337352M39506
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 FBN2

3.78e-0337352M27134
PathwayREACTOME_FATTY_ACYL_COA_BIOSYNTHESIS

ACSL6 ACSL5

3.78e-0337352M729
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 FBN2

4.19e-0339352MM14601
PathwayPID_AMB2_NEUTROPHILS_PATHWAY

LRP1 CCN2

4.62e-0341352M159
PathwayKEGG_FATTY_ACID_METABOLISM

ACSL6 ACSL5

4.84e-0342352M699
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

FBN1 FBN2 ADAMTS4

4.97e-03140353M587
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 FBN2

5.31e-0344352M26969
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

LRP1 LRP2

5.54e-0345352MM15344
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

FBN1 FBN2 ADAMTS4 ITGAL

6.26e-03300354M610
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

LRP1 LRP2

6.29e-0348352M27642
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

5.64e-13949516245338
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

1.13e-121049523665443
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

3.54e-121249515465494
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

5.74e-121349511578869
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

8.92e-121449514757642
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

1.34e-111549512971992
Pubmed

Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.

DLL4 DLL1 NOTCH2 NOTCH3

1.74e-11549421726900
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

1.94e-111649512617809
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

1.94e-111649517273555
Pubmed

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

2.75e-111749518694942
Pubmed

Segmental expression of Notch and Hairy genes in nephrogenesis.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

2.75e-111749515821257
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

3.80e-111849518093989
Pubmed

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

3.80e-111849515689374
Pubmed

Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

5.15e-111949516518823
Pubmed

Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.

JAG2 DLL4 CCN2 DLL1 NOTCH2 NOTCH3

6.68e-114849635247391
Pubmed

Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

9.00e-112149528656980
Pubmed

Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

1.16e-102249521750033
Pubmed

Human ligands of the Notch receptor.

JAG2 DLL1 NOTCH2 NOTCH3

1.21e-10749410079256
Pubmed

The distribution of Notch receptors and their ligands during articular cartilage development.

JAG2 DLL1 NOTCH2 NOTCH3

1.21e-10749412846471
Pubmed

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

1.49e-102349514701881
Pubmed

Aberrant epidermal differentiation and disrupted ΔNp63/Notch regulatory axis in Ets1 transgenic mice.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

1.49e-102349524337118
Pubmed

Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.

JAG2 DLL1 NOTCH2 NOTCH3

2.42e-1084949858718
Pubmed

Notch/Delta expression in the developing mouse lung.

JAG2 DLL1 NOTCH2 NOTCH3

2.42e-10849411044610
Pubmed

Notch signaling controls liver development by regulating biliary differentiation.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

2.89e-102649519369401
Pubmed

Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.

JAG2 DLL1 NOTCH2 NOTCH3

4.36e-10949411118901
Pubmed

Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

5.21e-102949525535917
Pubmed

Notch signaling regulates ovarian follicle formation and coordinates follicular growth.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

6.24e-103049524552588
Pubmed

Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle.

DLL4 DLL1 NOTCH2 NOTCH3

7.25e-101049424015274
Pubmed

Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.

JAG2 DLL1 NOTCH2 NOTCH3

1.14e-091149410878608
Pubmed

Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.

JAG2 DLL1 NOTCH2 NOTCH3

1.14e-091149412866128
Pubmed

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

1.21e-093449521311046
Pubmed

Notch signaling regulates smooth muscle differentiation of epicardium-derived cells.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

1.41e-093549521252157
Pubmed

Jagged1 is Essential for Radial Glial Maintenance in the Cortical Proliferative Zone.

JAG2 DLL1 NOTCH2 NOTCH3

2.46e-091349431202705
Pubmed

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.

JAG2 DLL4 DLL1

2.63e-09349321372153
Pubmed

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.

JAG2 DLL4 NOTCH2

2.63e-09349328572448
Pubmed

Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

3.25e-094149522675208
Pubmed

The notch pathway positively regulates programmed cell death during erythroid differentiation.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

4.69e-094449517476283
Pubmed

Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.

JAG2 DLL1 NOTCH2 NOTCH3

4.69e-091549417194759
Pubmed

Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway.

JAG2 DLL1 NOTCH2 NOTCH3

4.69e-09154949291577
Pubmed

Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.

JAG2 DLL1 NOTCH2 NOTCH3

4.69e-091549412167404
Pubmed

COUP-TFI controls Notch regulation of hair cell and support cell differentiation.

JAG2 DLL1 NOTCH2 NOTCH3

4.69e-091549416914494
Pubmed

Notch gene expression during pancreatic organogenesis.

JAG2 DLL1 NOTCH2 NOTCH3

6.25e-091649410842072
Pubmed

Notch Dosage: Jagged1 Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice.

JAG2 DLL1 NOTCH2 NOTCH3

6.25e-091649432161758
Pubmed

Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking.

DLL4 DLL1 NOTCH2 NOTCH3

8.16e-091749439315665
Pubmed

Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.

JAG2 ZNRF3 DLL4 DLL1 NOTCH2

9.09e-095049527510977
Pubmed

Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate.

JAG2 DLL4 DLL1

1.05e-08449320602435
Pubmed

Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2.

DLL4 DLL1 NOTCH2

1.05e-08449332820046
Pubmed

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.

DLL4 DLL1 NOTCH2

1.05e-08449328319044
Pubmed

LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer.

DLL4 LRP1 NOTCH2

1.05e-08449338462037
Pubmed

RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.

DLL4 DLL1 NOTCH2 NOTCH3

1.33e-081949420335360
Pubmed

Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors.

JAG2 DLL1 NOTCH3

2.62e-08549311006133
Pubmed

Functional diversity of notch family genes in fetal lung development.

JAG2 NOTCH2 NOTCH3

2.62e-08549315064243
Pubmed

Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).

DLL4 NOTCH2 NOTCH3

2.62e-08549323675950
Pubmed

Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells.

JAG2 DLL1 NOTCH3

2.62e-08549321602525
Pubmed

Analysis of coding-polymorphisms in NOTCH-related genes reveals NUMBL poly-glutamine repeat to be associated with schizophrenia in Brazilian and Danish subjects.

JAG2 NOTCH2 NOTCH3

2.62e-08549316899352
Pubmed

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice.

DLL4 DLL1 NOTCH2

2.62e-08549330181175
Pubmed

Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis.

DLL4 DLL1 NOTCH2 NOTCH3

3.02e-082349419897741
Pubmed

Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility.

DLL4 DLL1 NOTCH2 NOTCH3

3.02e-082349436239412
Pubmed

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2.

JAG2 DLL1 NOTCH2

5.24e-08649310958687
Pubmed

Expression of Deltex1 during mouse embryogenesis: comparison with Notch1, 2 and 3 expression.

DLL1 NOTCH2 NOTCH3

5.24e-08649311731257
Pubmed

Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura.

DLL1 NOTCH2 NOTCH3

5.24e-08649319603167
Pubmed

Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches.

DLL4 DLL1 NOTCH2

5.24e-08649319217325
Pubmed

Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation.

DLL1 NOTCH2 NOTCH3

5.24e-0864939882480
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

FBN1 FBN2 LRP1 LRP2 CRB1

5.46e-087149533541421
Pubmed

Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.

DLL4 DLL1 NOTCH2 NOTCH3

5.96e-082749421791528
Pubmed

Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.

JAG2 NOTCH2 NOTCH3

9.16e-08749310383933
Pubmed

GCNT1-Mediated O-Glycosylation of the Sialomucin CD43 Is a Sensitive Indicator of Notch Signaling in Activated T Cells.

DLL4 DLL1 NOTCH2

9.16e-08749332060138
Pubmed

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.

DLL4 DLL1 NOTCH2

9.16e-08749327576369
Pubmed

Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling.

DLL1 NOTCH2 NOTCH3

9.16e-08749324711412
Pubmed

The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro.

DLL4 DLL1 NOTCH2

9.16e-08749330289388
Pubmed

Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis.

JAG2 NOTCH2 NOTCH3

9.16e-08749316169548
Pubmed

Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.

JAG2 ADAMTS4 NOTCH2 NOTCH3

9.27e-083049419054571
Pubmed

Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.

JAG2 DLL4 DLL1 NOTCH2

1.38e-073349416000382
Pubmed

Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

1.44e-078649535103284
Pubmed

The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.

JAG2 TECTA DLL1

1.46e-07849316141228
Pubmed

P4 down-regulates Jagged2 and Notch1 expression during primordial folliculogenesis.

JAG2 NOTCH2 NOTCH3

1.46e-07849322652674
Pubmed

Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis.

DLL1 NOTCH2 NOTCH3

1.46e-07849315465493
Pubmed

Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis.

DLL4 DLL1 NOTCH2 NOTCH3

1.56e-073449417015435
Pubmed

The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina.

JAG2 DLL4 DLL1 NOTCH2

1.76e-073549428402857
Pubmed

Notch signaling is essential for vascular morphogenesis in mice.

JAG2 DLL4 DLL1

2.19e-07949310837027
Pubmed

Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification.

JAG2 DLL1 NOTCH2 NOTCH3

2.22e-073749424673559
Pubmed

The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

3.06e-0710049524859004
Pubmed

Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.

JAG2 NOTCH2 NOTCH3

4.30e-071149316607638
Pubmed

Coexpression of Cux-1 and Notch signaling pathway components during kidney development.

DLL1 NOTCH2 NOTCH3

4.30e-071149315499562
Pubmed

A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.

DLL1 NOTCH2 NOTCH3

4.30e-07114939187150
Pubmed

Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium.

DLL1 NOTCH2 NOTCH3

5.73e-071249310952889
Pubmed

Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression.

DLL1 NOTCH2 NOTCH3

5.73e-071249314732396
Pubmed

Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation.

JAG2 DLL1 NOTCH2

7.44e-071349311171333
Pubmed

The G4 resolvase RHAU regulates ventricular trabeculation and compaction through transcriptional and post-transcriptional mechanisms.

JAG2 DHX36 DLL4

7.44e-071349334838591
Pubmed

Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells.

DLL1 NOTCH2 NOTCH3

7.44e-071349323132245
Pubmed

Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments.

JAG2 DLL4 DLL1

1.45e-061649322464328
Pubmed

Requirement of Math1 for secretory cell lineage commitment in the mouse intestine.

DLL1 NOTCH2 NOTCH3

1.45e-061649311739954
Pubmed

The Cellular Prion Protein Controls Notch Signaling in Neural Stem/Progenitor Cells.

JAG2 NOTCH2 NOTCH3

1.45e-061649327641601
Pubmed

Notch signalling controls pancreatic cell differentiation.

DLL1 NOTCH2 NOTCH3

1.76e-061749310476967
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

1.94e-06249212399449
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

1.94e-06249221851253
Pubmed

Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.

FBN1 FBN2

1.94e-06249212429739
Pubmed

Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism.

DLL1 NOTCH2

1.94e-06249214660750
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

1.94e-06249230044367
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

1.94e-06249221440062
InteractionNTN5 interactions

JAG2 FBN1 FBN2 LRP2 NOTCH2 NOTCH3

1.51e-1124476int:NTN5
InteractionZFP41 interactions

FBN1 FBN2 LRP1 LRP2 NOTCH2 NOTCH3

3.83e-0957476int:ZFP41
InteractionMFAP5 interactions

JAG2 FBN1 FBN2 DLL1 NOTCH3

1.33e-0752475int:MFAP5
InteractionIGFL3 interactions

JAG2 FBN2 LRP2 NOTCH2 NOTCH3

8.47e-0775475int:IGFL3
InteractionZNF408 interactions

FBN1 FBN2 SSX2IP LRP2 NOTCH2 NOTCH3

1.05e-06145476int:ZNF408
InteractionMFAP2 interactions

JAG2 FBN1 FBN2

2.58e-0612473int:MFAP2
InteractionST14 interactions

JAG2 FBN1 FBN2 CRIM1 NOTCH2 NOTCH3

8.26e-06207476int:ST14
InteractionZDHHC15 interactions

FBN1 FBN2 LRP1 LRP2 CRB1

1.05e-05125475int:ZDHHC15
InteractionZNF224 interactions

FBN2 LRP2 NOTCH3

1.32e-0520473int:ZNF224
InteractionNOTCH4 interactions

DLL4 NOTCH2 NOTCH3

1.54e-0521473int:NOTCH4
InteractionMIB1 interactions

JAG2 DLL4 SSX2IP MPHOSPH9 DLL1 CRB1

6.06e-05295476int:MIB1
InteractionLTBP1 interactions

FBN1 FBN2 NOTCH2 NOTCH3

6.24e-0592474int:LTBP1
InteractionGREM2 interactions

FBN2 LRP2 NOTCH2

8.74e-0537473int:GREM2
InteractionDLL1 interactions

DLL1 NOTCH2 NOTCH3

9.47e-0538473int:DLL1
InteractionCCN2 interactions

LRP1 LRP2 CCN2

1.11e-0440473int:CCN2
InteractionJAG1 interactions

JAG2 NOTCH2 NOTCH3

1.19e-0441473int:JAG1
InteractionNOTCH3 interactions

JAG2 DLL1 NOTCH2 NOTCH3

1.39e-04113474int:NOTCH3
InteractionWNT3A interactions

JAG2 LRP1 NOTCH2

2.03e-0449473int:WNT3A
GeneFamilyLow density lipoprotein receptors

LRP1 LRP2

2.64e-0413342634
GeneFamilyAcyl-CoA synthetase family

ACSL6 ACSL5

1.08e-032634240
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

OBSCN PAPLN LINGO3

3.39e-03161343593
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

7.15e-1116485MM1296
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

7.15e-1116485M2207
CoexpressionNABA_ECM_GLYCOPROTEINS

MMRN1 LAMB4 EYS FBN1 FBN2 CRIM1 PAPLN CCN2 TECTA

7.93e-11196489M3008
CoexpressionNABA_CORE_MATRISOME

MMRN1 LAMB4 EYS FBN1 FBN2 CRIM1 PAPLN CCN2 TECTA

1.59e-09275489M5884
CoexpressionNABA_MATRISOME

MMRN1 LAMB4 EYS FBN1 FBN2 CRIM1 ADAMTS4 MUC17 PAPLN REG1B CCN2 ADAM2 FLG2 TECTA

2.53e-0910264814M5889
CoexpressionNABA_ECM_GLYCOPROTEINS

MMRN1 FBN1 FBN2 CRIM1 PAPLN CCN2 TECTA

5.59e-08191487MM17059
CoexpressionNABA_MATRISOME

MMRN1 FBN1 FBN2 CRIM1 ADAMTS4 MUC17 PAPLN REG1B CCN2 ADAM2 FLG2 TECTA

1.90e-0710084812MM17056
CoexpressionNABA_CORE_MATRISOME

MMRN1 FBN1 FBN2 CRIM1 PAPLN CCN2 TECTA

5.85e-07270487MM17057
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HRGL3

MMRN1 CRIM1 FAT3 LRP1 LRP2 PAPLN CCN2 NOTCH2 CRB1

8.53e-07574489M39056
CoexpressionHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

FBN1 FBN2 TFPI2 LRP1 CCN2 NOTCH2

1.72e-06200486M5930
CoexpressionJONES_OVARY_NK_CELL

FBN1 CRIM1 CCN2 NOTCH3

2.16e-0589484M48353
CoexpressionHALLMARK_NOTCH_SIGNALING

DLL1 NOTCH2 NOTCH3

2.75e-0532483M5903
CoexpressionGSE35543_IN_VIVO_NTREG_VS_IN_VITRO_ITREG_UP

PCNX2 TBC1D8 PKHD1 ADAM2 LYNX1

3.15e-05199485M9430
CoexpressionCERVERA_SDHB_TARGETS_2

FBN2 FAT3 PKHD1 NOTCH3

5.89e-05115484M19068
CoexpressionSATO_SILENCED_BY_DEACETYLATION_IN_PANCREATIC_CANCER

TFPI2 CCN2 NOTCH3

8.83e-0547483M11213
CoexpressionVART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN

CCN2 DLL1 NOTCH2 NOTCH3

1.10e-04135484M5825
CoexpressionKOMMAGANI_TP63_GAMMA_TARGETS

JAG2 NOTCH3

1.17e-049482M9630
CoexpressionACEVEDO_LIVER_CANCER_WITH_H3K9ME3_UP

LAMB4 ABCA13 FAT3 PKHD1

1.23e-04139484M6754
CoexpressionKYNG_DNA_DAMAGE_BY_4NQO_OR_UV

TFPI2 LRP1 ITGAL

1.83e-0460483M1816
CoexpressionVART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP

JAG2 DLL4 DLL1 NOTCH2

2.27e-04163484M12112
CoexpressionSENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP

TTF2 FBN1 ZNRF3 SSX2IP MPHOSPH9

2.35e-04305485M19875
CoexpressionAIZARANI_LIVER_C29_MVECS_2

MMRN1 CRIM1 ADAMTS4 TFPI2 CCN2

2.64e-04313485M39128
CoexpressionJONES_OVARY_PERICYTE

FBN1 CRIM1 CCN2 NOTCH3

2.78e-04172484M48351
CoexpressionMAHADEVAN_GIST_MORPHOLOGICAL_SWITCH

TFPI2 CCN2

3.40e-0415482M6900
CoexpressionAtlasJC_hmvEC_top-relative-expression-ranked_500

JAG2 MMRN1 ADAMTS4 DLL4 TFPI2 PAPLN CCN2 ACSL5

1.17e-05495478JC_hmvEC_500
CoexpressionAtlasJC_hmvEC_top-relative-expression-ranked_1000

JAG2 TBC1D8 MMRN1 CRIM1 ADAMTS4 DLL4 TFPI2 PAPLN CCN2 ACSL5

4.97e-059904710JC_hmvEC_1000
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 FAT3 PKHD1 LRP2 TECTA CRB1

2.27e-08160496c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 FAT3 PKHD1 LRP2 TECTA CRB1

2.27e-0816049625c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 ABCA13 FAT3 OBSCN PKHD1 LRP2

5.21e-081844962cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 ABCA13 FAT3 OBSCN PKHD1 LRP2

5.21e-08184496ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 ABCA13 FAT3 OBSCN PKHD1 LRP2

5.21e-081844962b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D|PND07-28-samps / Age Group, Lineage, Cell class and subclass

JAG2 SLC8A2 DLL4 PAPLN LINGO3

4.64e-07140495b9aeb7dda7f377b580dd8a44912f300721437387
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 PKHD1 ADAM2 TECTA CRB1

5.52e-0714549596712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABCA13 FAT3 PKHD1 ADAM2 TECTA

9.54e-07162495bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT3 LRP1 PAPLN NOTCH2 NOTCH3

1.21e-061704955570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 ABCA13 FAT3 PKHD1 LRP2

1.65e-061814956956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 ZNRF3 ABCA13 FAT3 PKHD1

1.74e-0618349592fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

JAG2 MMRN1 EYS DLL4 TFPI2

2.09e-061904951307688255a1250fa300edf2c41f1affe31dcc98
ToppCell390C-Endothelial_cells-Endothelial-B_(Artery)|390C / Donor, Lineage, Cell class and subclass (all cells)

JAG2 CRIM1 ADAMTS4 DLL4 CCN2

2.31e-06194495f8a59bd4609d147d8a706bf606e9e8173c9992a3
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FBN1 CRIM1 TFPI2 SSX2IP CCN2

2.31e-06194495f44394c8a6f86483063f2f5722f003a8a0a70254
ToppCell390C-Endothelial_cells-Endothelial-B_(Artery)-|390C / Donor, Lineage, Cell class and subclass (all cells)

JAG2 CRIM1 ADAMTS4 DLL4 CCN2

2.31e-0619449504b1acc2e879feafb43f75435281c5acd8d23be2
ToppCellCOVID-19-Heart-Fib_2|Heart / Disease (COVID-19 only), tissue and cell type

PCNX2 FBN1 LRP1 CCN2 NOTCH2

2.31e-06194495d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 ABCA13 PKHD1 LRP2 CCN2

2.31e-061944958ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FBN1 FBN2 ABCA13 FAT3 FLG2

2.37e-06195495d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FBN1 FBN2 ABCA13 FAT3 FLG2

2.37e-0619549519853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JAG2 MMRN1 CRIM1 DLL4 CCN2

2.49e-061974959244f087ba4b60fdc81d54ce91860de715b3e12c
ToppCell390C-Endothelial_cells|390C / Donor, Lineage, Cell class and subclass (all cells)

MMRN1 CRIM1 ADAMTS4 DLL4 CCN2

2.49e-06197495aa381acea0f7882d39435a6f713386bf0588b5f8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JAG2 MMRN1 CRIM1 DLL4 CCN2

2.56e-06198495218f33e068eb126458ec33176de3cfa6fc06ddf0
ToppCellsevere-HLA-DR+_CD83+_Monocyte|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TBC1D8 NOTCH2NLB MUC17 LRP1 NOTCH2

2.56e-06198495a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JAG2 MMRN1 CRIM1 DLL4 CCN2

2.56e-06198495e1fa02184ce93c4f8aa5cf04b70949cd4c425ff0
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JAG2 MMRN1 CRIM1 DLL4 CCN2

2.56e-061984957cddd474416651088a4e08edfc0ac420ff10a5fe
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 FBN2 LRP1 CCN2 DLL1

2.62e-06199495e78f661b40da34768469549b6e755d330be6bbd8
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2|Control_saline / Treatment groups by lineage, cell group, cell type

FBN2 CRIM1 LRP1 NOTCH2 NOTCH3

2.69e-06200495bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 ZNRF3 ABCA13 PKHD1

2.42e-05153494d6526d17826470534b766df144c74e73eb83fdad
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN1 FBN2 FAT3 FLG2

2.54e-051554948fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCellfacs-Liver-Non-hepatocytes-3m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBC1D8 OBSCN LINGO3 NOTCH3

2.88e-05160494237430af14830b38e58da8a4224036e5c6b71c5b
ToppCelldroplet-Spleen-nan-21m-Myeloid-macrophage_dendritic_cell_progenitor|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBC1D8 DLL4 OBSCN NOTCH3

3.57e-051694947962165cab84af73d20b56eb70b1ed87c94025ef
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 FAT3 PKHD1 LRP2

3.57e-0516949412bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JAG2 DLL4 TFPI2 DLL1

3.65e-0517049455fe16d98ea284d05fb899888e4569c685644c7b
ToppCelldroplet-Spleen-nan-18m-Myeloid-macrophage_dendritic_cell_progenitor|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBC1D8 DLL4 OBSCN NOTCH3

3.73e-051714944e856441063e9825b6f87a1d3dd19c77dae4662c
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 CRIM1 PAPLN CCN2

4.09e-051754941799a7be623dc3bf53ba580a7c47d2619969d708
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 ABCA13 FAT3 PKHD1

4.18e-05176494327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

JAG2 FBN2 CRIM1 DLL4

4.18e-0517649452af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ZNRF3 PKHD1 LRP2 PAPLN

4.37e-05178494544379f5a6145429762258d426b876bb36c112f5
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN2 OBSCN CCN2 DLL1

4.46e-05179494a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCellPCW_05-06-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

JAG2 MMRN1 EYS DLL4

4.56e-051804945861b44acfb8fe92c281c8355bf19c059b3dcd64
ToppCellmetastatic_Brain-Fibroblasts-Myofibroblasts|metastatic_Brain / Location, Cell class and cell subclass

FBN1 FBN2 FAT3 CCN2

4.66e-05181494bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN2 CRIM1 PAPLN NOTCH3

4.86e-051834948a799807fbf24456a9811e0c64068187940a2f71
ToppCellCOPD-Endothelial-VE_Venous|COPD / Disease state, Lineage and Cell class

MMRN1 CRIM1 ADAMTS4 CCN2

4.97e-0518449444d716e7ba46a1ed03f5992631289653f8fd7d5e
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CRIM1 ADAMTS4 PAPLN NOTCH3

4.97e-05184494327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

FBN1 ADAMTS4 FAT3 NOTCH3

5.18e-05186494cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 ADAMTS4 PAPLN CCN2

5.18e-051864945473283fb95cee556b1f6934cf72169b676b5bcc
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ZNRF3 PKHD1 LRP2 PAPLN

5.18e-051864945784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein|Children_(3_yrs) / Lineage, Cell type, age group and donor

MMRN1 CRIM1 CCN2 DLL1

5.29e-05187494e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 ABCA13 LRP2

5.29e-051874944e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 ABCA13 LRP2

5.29e-05187494d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 ABCA13 LRP2

5.29e-05187494827eae63fabf6892a82ce7779b5f395958d3d628
ToppCellPCW_05-06-Endothelial-Endothelial_mature-endo_venous_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

JAG2 MMRN1 TFPI2 DLL1

5.29e-0518749403de3c2df31bca0dc4e3718bada708d8fe8b69b9
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

JAG2 EYS DLL4 TFPI2

5.40e-05188494366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN2 OBSCN PAPLN DLL1

5.40e-05188494997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCellControl-Endothelial-VE_Venous|World / Disease state, Lineage and Cell class

MMRN1 CRIM1 ADAMTS4 CCN2

5.51e-05189494f83f7521e377ded1522639e9a35c98b3e2725bac
ToppCellP03-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SLC8A2 CRIM1 CCN2 NOTCH3

5.51e-05189494b5439ef221106f6d54434f268485e9bb17b39102
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT3 LRP1 NOTCH2 NOTCH3

5.51e-0518949445e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CRIM1 ADAMTS4 OBSCN NOTCH3

5.63e-051904944eb92aef1ee868f4537483d19014d947b7684612
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JAG2 MMRN1 DLL4 CCN2

5.63e-0519049406bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CRIM1 ADAMTS4 OBSCN NOTCH3

5.63e-051904947be4341e2909101d756f14031c21e705eb45e69a
ToppCellControl-Endothelial-VE_Venous|Control / Disease state, Lineage and Cell class

MMRN1 CRIM1 ADAMTS4 CCN2

5.74e-05191494617546cf4883dedf3323e03a53ba5adec334cf8e
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

FBN1 ADAMTS4 FAT3 NOTCH3

5.74e-0519149478c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN1 CRIM1 ADAMTS4 DLL4

5.86e-05192494945153c41dde6e90d103206955e1707b54eb0665
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN1 CRIM1 ADAMTS4 DLL4

5.86e-051924946ab50579c63f31ca2cd41063a99b129f11c07510
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-SVEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MMRN1 CRIM1 ADAMTS4 CCN2

5.86e-05192494c3dda7c48732b0b8bde36de282d64192f5e9b98f
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 ADAMTS4 LRP1 PAPLN

5.86e-05192494df1545670370fb1010c567cd059c2783eab315f7
ToppCellLPS_only-Stromal_mesenchymal|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 ADAMTS4 FAT3 LRP1

5.86e-05192494162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JAG2 MMRN1 DLL4 CCN2

5.98e-051934943f8280ef849d95b2fcea5e6824b95a07febc96d0
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA13 PKHD1 PAPLN CCN2

5.98e-05193494ffa1932da2979d7b63dbac32eb5788346a3f5b2a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA13 TFPI2 PKHD1 CCN2

5.98e-051934940f2167eef8203a5659c8c72e4e77646003d64797
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 CRIM1 CCN2 NOTCH3

5.98e-05193494800b0f5705fefcd3608e37801afae8a94474723e
ToppCellLA|World / Chamber and Cluster_Paper

PCNX2 FBN1 LRP1 LRP2

5.98e-05193494d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellIPF-Endothelial-VE_Arterial|World / Disease state, Lineage and Cell class

JAG2 CRIM1 DLL4 CCN2

5.98e-0519349470a9aadda83a97e06e9bc2d1327ce60dd3c58767
ToppCell356C-Endothelial_cells-Endothelial-A_(Artery)|356C / Donor, Lineage, Cell class and subclass (all cells)

MMRN1 CRIM1 ADAMTS4 CCN2

6.10e-051944942e5b195e02dcd5e9432b9a98b22e0478e65b9ba2
ToppCellnucseq-Mesenchymal-Myocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FBN1 OBSCN CCN2 NOTCH3

6.10e-051944942d66091097e106c7bee22e5281f50724700bdf8d
ToppCell(6)_Endothelial-B_(Artery)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

JAG2 CRIM1 DLL4 CCN2

6.10e-051944940cf4e67d4024652794b5bfdd4a71a7d98900b4c8
ToppCell356C-Endothelial_cells-Endothelial-A_(Artery)-|356C / Donor, Lineage, Cell class and subclass (all cells)

MMRN1 CRIM1 ADAMTS4 CCN2

6.10e-05194494b6b5b0ab506b05a005ba8a05a3c7f4c725ba9200
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MMRN1 CRIM1 DLL4 CCN2

6.10e-05194494ea5e1bc8d9e27cabfe1fb833ca47ec0893593b12
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MMRN1 CRIM1 DLL4 CCN2

6.10e-05194494cceb7c88492bb6cd531e1c2651638da1ddf30931
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FBN1 CRIM1 TFPI2 NOTCH3

6.22e-0519549478cfde21dde4b877fc76c8b0d5ddaabe44b912d7
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MMRN1 CRIM1 DLL4 CCN2

6.22e-051954944658fb197657d7692ee344ae76b11b0210c418ba
ToppCellCOVID-19-Heart-Low_count_Fib|COVID-19 / Disease (COVID-19 only), tissue and cell type

FBN1 RPS2 LRP1 CCN2

6.22e-05195494e09590d1f51d5fa57fceb84c9f48f84b23d4d224
ToppCellCOVID-19-Heart-Fib_1|Heart / Disease (COVID-19 only), tissue and cell type

FBN1 LRP1 CCN2 NOTCH2

6.22e-05195494f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 FAT3 LRP1 CCN2

6.22e-05195494df409f94f4e83be89f7a608058ee07ce3ce3a149
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBC1D8 CRIM1 ADAMTS4 DLL4

6.22e-051954944db30b3bc65c25626f828cd4f867f20c71809898
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 FAT3 LRP1 CCN2

6.22e-051954944243190ad291d56694e2155954dbaa879c9d3844
ToppCell(6)_Endothelial-D|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

MMRN1 CRIM1 DLL4 CCN2

6.22e-05195494c0005a5f2dc63a0cc254c45ac89a2f42df6f8bde
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 ADAMTS4 TFPI2 LRP1

6.22e-05195494fc43cd295f2cc3f6e9442232e028944f011c82cc
ToppCellEndothelial|World / shred by cell class for bronchial biopsy

MMRN1 CRIM1 DLL4 CCN2

6.22e-05195494f0e46e859f7a9bdead3203889f7e20fa21f76ff0
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D122|Adult / Lineage, Cell type, age group and donor

FBN1 CRIM1 FAT3 CCN2

6.22e-05195494aa0add081881d349099d12efca5cdee098038d4e
ToppCelldroplet-Bladder-nan-24m-Endothelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN1 ADAMTS4 DLL4 NOTCH3

6.35e-051964949a90dd26e7a43e3fd55e7c5d8354cfa4cdd5a6cc
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M|organoid_Kanton_Nature / Sample Type, Dataset, Time_group, and Cell type.

MMRN1 FBN2 LRP2 CCN2

6.35e-051964941e9ccbd5be7839a74108f0cd07a6d2d736bc7f1b
ToppCellPND28-Mesenchymal|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 LRP1 CCN2 NOTCH3

6.35e-05196494119265efd2219f328d8152dbee52af8327aec89c
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBN1 FAT3 LRP1 CCN2

6.35e-0519649442e9828222a9663525d571633e8a454c30bfa7f8
ToppCelldroplet-Bladder-nan-24m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN1 ADAMTS4 DLL4 NOTCH3

6.35e-0519649404dfef1bd4ebb0e9469ae80024dc177e469a2560
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Endothelial-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

JAG2 MMRN1 CRIM1 ADAMTS4

6.47e-05197494f969685dee212f33a6f09e54c0cd1fd24ffef546
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 ADAMTS4 TFPI2 LRP1

6.47e-05197494ab5d3ebc73bd7cfc64381d14b92878b370205186
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

JAG2 MMRN1 CRIM1 ADAMTS4

6.47e-051974941a137af40697137bb9d2b5caf2b1ffda55f04461
ToppCelldistal-Endothelial-Bronchial_Vessel_1-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MMRN1 CRIM1 ADAMTS4 CCN2

6.47e-051974940d1afd1ad7489c071db08b3dfff598423097d7e0
ToppCelldroplet-Bladder-nan-24m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN1 ADAMTS4 DLL4 NOTCH3

6.47e-05197494488e85991c5e668afb7672942726d9295b8fc7d8
ComputationalMetal / Ca ion binding.

FBN1 FBN2 LRP1 ITGAL CRB1

2.52e-05133295MODULE_324
ComputationalAdhesion molecules.

MMRN1 FBN1 FBN2 CCN2 ITGAL

3.33e-05141295MODULE_122
Druglead stearate

JAG2 FBN2 DLL4 DLL1 NOTCH2 NOTCH3

2.28e-0884486CID000061258
DrugSaquinavir mesylate [149845-06-7]; Up 200; 5.2uM; HL60; HT_HG-U133A

PCNX2 CRIM1 LRP1 LRP2 TECTA SLC25A23

3.63e-061984866127_UP
DrugAC1L1GUQ

JAG2 DLL4 DLL1 NOTCH2

3.73e-0650484CID000003849
DrugA25152

JAG2 DLL1 NOTCH2 NOTCH3

8.87e-0662484CID000002956
Druggamma-secretase inhibitor I

NOTCH2 NOTCH3

2.60e-054482CID011754711
Drugpeptidomimetic inhibitor

JAG2 DLL4 DLL1 NOTCH2 NOTCH3

4.91e-05190485CID005288092
DrugAdamantamine fumarate [80789-67-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A

TFPI2 SSX2IP LRP2 ADAM2 SLC25A23

5.70e-051964854806_UP
DrugDelcorine; Up 200; 8.4uM; MCF7; HT_HG-U133A

PCNX2 LAMB4 FBN1 FBN2 CCN2

5.83e-051974854737_UP
Drug(-)-MK 801 hydrogen maleate [77086-19-2]; Up 200; 11.8uM; MCF7; HT_HG-U133A

LAMB4 FBN1 CCN2 ADAM2 NOTCH3

5.98e-051984855003_UP
DrugvgBE

NOTCH2 NOTCH3

6.49e-056482CID000193461
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2

7.44e-063472DOID:65 (implicated_via_orthology)
DiseaseColorectal Carcinoma

FBN2 ABCA13 TFPI2 OBSCN PKHD1 LRP1 LRP2 ACSL5

1.37e-05702478C0009402
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

1.49e-054472DOID:0060249 (is_implicated_in)
Diseaseadenocarcinoma (implicated_via_orthology)

NOTCH2 NOTCH3

5.19e-057472DOID:299 (implicated_via_orthology)
Diseasecentral nervous system cancer (implicated_via_orthology)

NOTCH2 NOTCH3

5.19e-057472DOID:3620 (implicated_via_orthology)
Diseasecancer (implicated_via_orthology)

DLL4 SSRP1 DLL1 NOTCH2 NOTCH3

6.69e-05268475DOID:162 (implicated_via_orthology)
Diseaseaortic aneurysm

FBN1 LRP1

1.11e-0410472EFO_0001666
Diseaseintraocular pressure measurement

TBC1D8 TTF2 FBN1 FBN2 ZNRF3 PKHD1

1.51e-04509476EFO_0004695
DiseaseMammary Carcinoma, Human

JAG2 DLL4 TFPI2 DLL1 NOTCH2 NOTCH3

1.78e-04525476C4704874
DiseaseMammary Neoplasms, Human

JAG2 DLL4 TFPI2 DLL1 NOTCH2 NOTCH3

1.78e-04525476C1257931
DiseaseMammary Neoplasms

JAG2 DLL4 TFPI2 DLL1 NOTCH2 NOTCH3

1.82e-04527476C1458155
Diseasehomostachydrine measurement

ACSL6 EYS

1.92e-0413472EFO_0021164
DiseaseMigraine Disorders

LRP1 NOTCH3

1.92e-0413472C0149931
DiseaseBreast Carcinoma

JAG2 DLL4 TFPI2 DLL1 NOTCH2 NOTCH3

2.03e-04538476C0678222
Diseasecortical surface area measurement

JAG2 ACSL6 FBN1 FBN2 FAT3 C8orf82 PKHD1 MARCHF7 MPHOSPH9

2.35e-041345479EFO_0010736
DiseaseMalignant neoplasm of breast

JAG2 DLL4 TFPI2 OBSCN TECTA DLL1 NOTCH2 NOTCH3

2.67e-041074478C0006142
DiseaseGlioblastoma

JAG2 NOTCH2 NOTCH3

2.75e-0479473C0017636
Diseasedilated cardiomyopathy (implicated_via_orthology)

JAG2 DLL4 DLL1

2.86e-0480473DOID:12930 (implicated_via_orthology)
Diseaseacute myeloid leukemia (is_implicated_in)

ACSL6 TFPI2 KAT6A

3.30e-0484473DOID:9119 (is_implicated_in)
DiseaseGiant Cell Glioblastoma

JAG2 NOTCH2 NOTCH3

3.30e-0484473C0334588
Diseasediet measurement, HOMA-B

PCNX2 FAT3

4.17e-0419472EFO_0004469, EFO_0008111
DiseaseSquamous cell carcinoma of esophagus

FAT3 NOTCH2 NOTCH3

4.73e-0495473C0279626
DiseaseCarcinoma, Pancreatic Ductal

JAG2 NOTCH3

6.70e-0424472C0887833
DiseaseGlioblastoma Multiforme

JAG2 NOTCH2 NOTCH3

7.45e-04111473C1621958
Diseasebrain cancer (implicated_via_orthology)

NOTCH2 NOTCH3

7.88e-0426472DOID:1319 (implicated_via_orthology)
Diseaseretinitis pigmentosa (implicated_via_orthology)

EYS CRB1

8.50e-0427472DOID:10584 (implicated_via_orthology)
Diseasecomplement factor H-related protein 2 measurement

REG1B CRB1

9.81e-0429472EFO_0600055
Diseasecolorectal cancer (implicated_via_orthology)

NOTCH2 NOTCH3

1.05e-0330472DOID:9256 (implicated_via_orthology)
Diseasespontaneous coronary artery dissection

FBN1 LRP1

1.12e-0331472EFO_0010820
Diseaseintestinal cancer (implicated_via_orthology)

NOTCH2 NOTCH3

1.19e-0332472DOID:10155 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
ACSGDGGVSYTQGQS

C8orf82

21

Q6P1X6
VSGNCGISDSGYTQC

ADAM2

521

Q99965
ASRPGSQEGCYSGCS

SSX2IP

586

Q9Y2D8
NGATCSNSGQRSYTC

DLL4

296

Q9NR61
CNTGSRCRNFSYEGS

ABCA13

76

Q86UQ4
GNVCVGSGARSSFSC

KRT26

31

Q7Z3Y9
RCASGFTGEDCQYST

NOTCH2NLB

91

P0DPK3
RCASGFTGEDCQYST

NOTCH2

91

Q04721
RTGSSQSSCCGQYGS

FLG2

371

Q5D862
QSSCCGQYGSGGSQS

FLG2

376

Q5D862
NGGTCIESGTSVYCN

EYS

2621

Q5T1H1
RNGGECTVNGTTFSC

EYS

2906

Q5T1H1
QNGGTCINGRTSFTC

MMRN1

1051

Q13201
CSNGGTCYDSGDTFR

JAG2

721

Q9Y219
VYGTCSQLCTNTDGS

LRP1

156

Q07954
RVSTNQCSGYGSGEG

PCNX2

461

A6NKB5
CRNGGTCRQSGDLTY

NOTCH3

206

Q9UM47
TQGSFLCQCGRGYTG

NOTCH3

411

Q9UM47
CNVDSCSVSSGYGTF

MPHOSPH9

36

Q99550
GTYTCVASNAGGNDT

LINGO3

476

P0C6S8
NGERCGASSFTCSNG

LRP2

2696

P98164
TGEYTCTCGSQATSA

OBSCN

3956

Q5VST9
SICGNSSSQSSCSYG

KAT6A

1576

Q92794
DCSRTCGGGVQFSSR

ADAMTS4

531

O75173
GATCTNTGQGSYTCS

DLL1

301

O00548
RGSYTCECNDGFTAS

FBN1

2311

P35555
GGTVYRSGESFQSSC

CCN2

106

P29279
AESCGSGNSTGYQIR

DHX36

281

Q9H2U1
SGGYQCTCLSQFTGR

FAT3

4041

Q8TDW7
CASQRNESCGGTFGI

CRIM1

66

Q9NZV1
EAYGQTECTGGCTFT

ACSL5

441

Q9ULC5
CTNCTTSAGRNVGNG

MARCHF7

96

Q9H992
STTSCCQYDLCNGTG

LYNX1

81

P0DP58
LQGYTGTQCGECSTG

LAMB4

941

A4D0S4
SCSSLGCGSNGFRYL

KRTAP13-3

116

Q3SY46
YRCECNEGFQSSSSG

FBN2

2361

P35556
ENRYSCNCTGSGFTG

CRB1

281

P82279
SANAGYCASLTSCSG

REG1B

131

P48304
RTTTCFGDGCQNTAS

MUC17

4131

Q685J3
RTCSDCSQGQGGFTV

PKHD1

2486

P08F94
STGSLYQCQSGTGHC

ITGAL

66

P20701
SGAQCITCSYKASSG

SSRP1

336

Q08945
EGYGQTECTAGCTFT

ACSL6

456

Q9UKU0
RLSTTYFNCTGGLCG

TECTA

836

O75443
ASCGGGSQSRSVYCI

PAPLN

376

O95428
GQRGSSSGSCSQECG

TBC1D8

1031

O95759
CTEVSNQGVYGSCST

ZNRF3

571

Q9ULT6
ACGTISSTCGQIASY

SLC25A23

381

Q9BV35
RTCDAFTYTGCGGND

TFPI2

181

P48307
DCYTSARGCTATLGN

RPS2

221

P15880
ACQVTAGGSSQCYRG

TTF2

511

Q9UNY4
SDTSTGGCQGSYRCQ

SLC8A2

36

Q9UPR5