Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	DRD5 GRID2 CHRFAM7A CHRNA7	2.45e-04	75	81	4	GO:0098960
GeneOntologyMolecularFunction	neurotransmitter receptor activity	DRD5 GRID2 CHRFAM7A CHRNA7	7.33e-04	100	81	4	GO:0030594
GeneOntologyMolecularFunction	hemoglobin binding	LRP2 CUBN	8.73e-04	11	81	2	GO:0030492
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	ABCC8 TRPM8 GRID2 CHRFAM7A CHRNA7	1.13e-03	193	81	5	GO:0015276
GeneOntologyMolecularFunction	acetylcholine binding	CHRFAM7A CHRNA7	1.23e-03	13	81	2	GO:0042166
GeneOntologyMolecularFunction	ligand-gated channel activity	ABCC8 TRPM8 GRID2 CHRFAM7A CHRNA7	1.24e-03	197	81	5	GO:0022834
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GRID2 CHRFAM7A CHRNA7	1.61e-03	57	81	3	GO:1904315
GeneOntologyMolecularFunction	chloride channel regulator activity	CHRFAM7A CHRNA7	1.65e-03	15	81	2	GO:0017081
GeneOntologyMolecularFunction	kinase binding	WWC2 GFRAL E2F1 NBEA STK39 CHRFAM7A CEACAM20 GFAP CHRNA7 WWC1 SLC12A5	1.79e-03	969	81	11	GO:0019900
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GRID2 CHRFAM7A CHRNA7	1.86e-03	60	81	3	GO:0099529
GeneOntologyMolecularFunction	adenylate cyclase binding	CHRFAM7A CHRNA7	1.88e-03	16	81	2	GO:0008179
GeneOntologyMolecularFunction	acetylcholine-gated monoatomic cation-selective channel activity	CHRFAM7A CHRNA7	2.12e-03	17	81	2	GO:0022848
GeneOntologyMolecularFunction	transmitter-gated channel activity	GRID2 CHRFAM7A CHRNA7	2.34e-03	65	81	3	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GRID2 CHRFAM7A CHRNA7	2.34e-03	65	81	3	GO:0022824
GeneOntologyMolecularFunction	gated channel activity	KCNV2 ABCC8 TRPM8 GRID2 CHRFAM7A CHRNA7	2.37e-03	334	81	6	GO:0022836
GeneOntologyMolecularFunction	toxic substance binding	CHRFAM7A CHRNA7	2.38e-03	18	81	2	GO:0015643
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	ABCC8 TRPM8 CHRFAM7A CHRNA7	2.54e-03	140	81	4	GO:0099094
GeneOntologyBiologicalProcess	synaptic transmission, dopaminergic	SLC6A2 DRD5 CHRFAM7A CHRNA7	9.53e-06	35	79	4	GO:0001963
GeneOntologyBiologicalProcess	endocytic hemoglobin import into cell	LRP2 CUBN	1.45e-05	2	79	2	GO:0020028
GeneOntologyBiologicalProcess	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	1.45e-05	2	79	2	GO:0001988
GeneOntologyBiologicalProcess	baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	4.33e-05	3	79	2	GO:0001982
GeneOntologyBiologicalProcess	generation of ovulation cycle rhythm	CHRFAM7A CHRNA7	8.65e-05	4	79	2	GO:0060112
GeneOntologyBiologicalProcess	sensory processing	CHRFAM7A CHRNA7	1.44e-04	5	79	2	GO:0050893
GeneOntologyCellularComponent	cell projection membrane	DRD5 BBS7 SYNE2 LRP2 CUBN CHRFAM7A CEACAM20 CHRNA7 WWC1 SLC12A5	5.68e-06	431	80	10	GO:0031253
GeneOntologyCellularComponent	cell surface	SLC6A2 MRC1 SLAMF6 LAYN GFRAL PLPPR4 ADAM20 VTCN1 LRP2 TRPM8 TNFRSF10D CUBN CHRFAM7A CEACAM20 CHRNA7	1.78e-05	1111	80	15	GO:0009986
GeneOntologyCellularComponent	external side of plasma membrane	SLAMF6 GFRAL PLPPR4 ADAM20 VTCN1 LRP2 TRPM8 CUBN CHRFAM7A CHRNA7	2.83e-05	519	80	10	GO:0009897
GeneOntologyCellularComponent	spine apparatus membrane	CHRFAM7A CHRNA7	4.33e-05	3	80	2	GO:0098897
GeneOntologyCellularComponent	side of membrane	SLAMF6 GFRAL PLPPR4 ADAM20 VTCN1 LRP2 TRPM8 GNAI3 CUBN CHRFAM7A GFAP CHRNA7	1.18e-04	875	80	12	GO:0098552
GeneOntologyCellularComponent	postsynaptic specialization membrane	DRD5 PLPPR4 GRID2 CHRFAM7A CHRNA7 SLC12A5	1.22e-04	201	80	6	GO:0099634
GeneOntologyCellularComponent	synaptic membrane	SLC6A2 DRD5 PLPPR4 TENM3 GRID2 NBEA CHRFAM7A CHRNA7 SLC12A5	3.82e-04	583	80	9	GO:0097060
GeneOntologyCellularComponent	spine apparatus	CHRFAM7A CHRNA7	5.12e-04	9	80	2	GO:0097444
GeneOntologyCellularComponent	postsynaptic membrane	DRD5 PLPPR4 GRID2 NBEA CHRFAM7A CHRNA7 SLC12A5	9.17e-04	405	80	7	GO:0045211
GeneOntologyCellularComponent	leading edge membrane	SYNE2 CHRFAM7A CHRNA7 WWC1 SLC12A5	1.27e-03	210	80	5	GO:0031256
MousePheno	airway basal cell hyperplasia	CHRFAM7A CHRNA7	2.40e-05	2	69	2	MP:0011115
MousePheno	abnormal airway basal cell differentiation	CHRFAM7A CHRNA7	2.40e-05	2	69	2	MP:0011114
MousePheno	abnormal airway basal cell morphology	CHRFAM7A CHRNA7	2.40e-05	2	69	2	MP:0011113
MousePheno	reduced long-term depression	GRID2 PREX1 GFAP WWC1	5.80e-05	43	69	4	MP:0001475
MousePheno	abnormal spatial learning	TRIM67 GRID2 NBEA CHRFAM7A PREX1 CHRNA7 WWC1 SLC12A5	6.15e-05	276	69	8	MP:0001463
MousePheno	abnormal GABA-mediated receptor currents	GRID2 CHRFAM7A CHRNA7	8.91e-05	18	69	3	MP:0004008
MousePheno	abnormal nicotine-mediated receptor currents	CHRFAM7A CHRNA7	1.43e-04	4	69	2	MP:0009475
MousePheno	persistent truncus arteriosus type i	TBC1D32 LRP2	2.38e-04	5	69	2	MP:0011661
Domain	DUF2075	SLFN13 SLFN11	5.56e-05	3	81	2	IPR018647
Domain	DUF2075	SLFN13 SLFN11	5.56e-05	3	81	2	PF09848
Domain	DEP	DEPDC7 PREX1 PREX2	1.14e-04	22	81	3	PF00610
Domain	DEP	DEPDC7 PREX1 PREX2	1.14e-04	22	81	3	PS50186
Domain	DEP	DEPDC7 PREX1 PREX2	1.14e-04	22	81	3	SM00049
Domain	EGF_1	FN1 TENM3 ADAM20 ADAM18 ATRNL1 LRP2 CUBN	1.20e-04	255	81	7	PS00022
Domain	DEP_dom	DEPDC7 PREX1 PREX2	1.31e-04	23	81	3	IPR000591
Domain	EGF_extracell	TENM3 ADAM18 ATRNL1 LRP2	1.33e-04	60	81	4	IPR013111
Domain	EGF_2	TENM3 ADAM18 ATRNL1 LRP2	1.33e-04	60	81	4	PF07974
Domain	EGF-like_CS	FN1 TENM3 ADAM20 ADAM18 ATRNL1 LRP2 CUBN	1.38e-04	261	81	7	IPR013032
Domain	AlbA_2	SLFN13 SLFN11	3.85e-04	7	81	2	PF04326
Domain	Schlafen	SLFN13 SLFN11	3.85e-04	7	81	2	IPR029684
Domain	Schlafen_AAA_dom	SLFN13 SLFN11	3.85e-04	7	81	2	IPR007421
Domain	EGF_3	TENM3 ADAM20 ADAM18 ATRNL1 LRP2 CUBN	5.50e-04	235	81	6	PS50026
Domain	GDS_CDC24_CS	FGD1 PREX1 PREX2	6.42e-04	39	81	3	IPR001331
Domain	EGF-like_dom	TENM3 ADAM20 ADAM18 ATRNL1 LRP2 CUBN	7.45e-04	249	81	6	IPR000742
Domain	EGF_2	TENM3 ADAM20 ADAM18 ATRNL1 LRP2 CUBN	1.03e-03	265	81	6	PS01186
Domain	-	MRC1 FN1	1.40e-03	13	81	2	2.10.10.10
Domain	FN_type2_col-bd	MRC1 FN1	1.63e-03	14	81	2	IPR000562
Domain	FN2_2	MRC1 FN1	1.63e-03	14	81	2	PS51092
Domain	fn2	MRC1 FN1	1.63e-03	14	81	2	PF00040
Domain	FN2_1	MRC1 FN1	1.63e-03	14	81	2	PS00023
Domain	FN2	MRC1 FN1	1.63e-03	14	81	2	SM00059
Domain	Disintegrin_CS	ADAM20 ADAM18	2.14e-03	16	81	2	IPR018358
Domain	-	E2F1 DEPDC7 KAT6B PREX1 PREX2	2.58e-03	218	81	5	1.10.10.10
Domain	DH_1	FGD1 PREX1 PREX2	2.59e-03	63	81	3	PS00741
Domain	ADAM_CR	ADAM20 ADAM18	2.72e-03	18	81	2	PF08516
Domain	RhoGEF	FGD1 PREX1 PREX2	3.22e-03	68	81	3	SM00325
Domain	-	ADAM20 ADAM18	3.36e-03	20	81	2	4.10.70.10
Domain	RhoGEF	FGD1 PREX1 PREX2	3.49e-03	70	81	3	PF00621
Domain	DH_2	FGD1 PREX1 PREX2	3.49e-03	70	81	3	PS50010
Domain	DH-domain	FGD1 PREX1 PREX2	3.63e-03	71	81	3	IPR000219
Domain	-	FGD1 PREX1 PREX2	3.63e-03	71	81	3	1.20.900.10
Domain	Disintegrin	ADAM20 ADAM18	3.70e-03	21	81	2	PF00200
Domain	DISIN	ADAM20 ADAM18	3.70e-03	21	81	2	SM00050
Domain	WHTH_DNA-bd_dom	E2F1 DEPDC7 KAT6B PREX1 PREX2	4.04e-03	242	81	5	IPR011991
Domain	-	CHRFAM7A CHRNA7	4.43e-03	23	81	2	1.20.120.370
Domain	Acetylcholine_rcpt_TM	CHRFAM7A CHRNA7	4.43e-03	23	81	2	IPR027361
Domain	C_TYPE_LECTIN_1	MRC1 LAYN ATRNL1	5.08e-03	80	81	3	PS00615
Domain	Ricin_B_lectin	GALNT14 MRC1	5.22e-03	25	81	2	PF00652
Pubmed	Sequential interplay of nicotinic and GABAergic signaling guides neuronal development.	CHRFAM7A CHRNA7 SLC12A5	1.22e-08	3	81	3	17158331
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	WWC2 TRIM67 PLPPR4 GKAP1 WWC1 LUZP1 SMG6	8.10e-07	218	81	7	33378226
Pubmed	Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis.	E2F1 CHRFAM7A CHRNA7	1.44e-06	10	81	3	35087060
Pubmed	The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.	HTRA1 TENM3 CHRFAM7A PREX1 CHRNA7	2.82e-06	94	81	5	23431145
Pubmed	Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo.	LRP2 CUBN	5.36e-06	2	81	2	15616221
Pubmed	Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	38070724
Pubmed	Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	19626424
Pubmed	Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	17012698
Pubmed	WW and C2 domain-containing proteins regulate hepatic cell differentiation and tumorigenesis through the hippo signaling pathway.	WWC2 WWC1	5.36e-06	2	81	2	29116649
Pubmed	Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	26451017
Pubmed	Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	34453977
Pubmed	Perinatal hypoxia-ischemia reduces α 7 nicotinic receptor expression and selective α 7 nicotinic receptor stimulation suppresses inflammation and promotes microglial Mox phenotype.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	24757672
Pubmed	Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	26999808
Pubmed	Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	27129924
Pubmed	Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	17291692
Pubmed	Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	23521765
Pubmed	Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	28258105
Pubmed	The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	19344760
Pubmed	Loss of α7nAChR enhances endothelial-to-mesenchymal transition after myocardial infarction via NF-κB activation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	35926661
Pubmed	The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	17640819
Pubmed	Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	23431157
Pubmed	Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	29114104
Pubmed	Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	33995108
Pubmed	E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	32552811
Pubmed	Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	24836856
Pubmed	Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer's disease via activation of α7nAChR.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	31904546
Pubmed	Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	15948184
Pubmed	Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	35678315
Pubmed	Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	33117372
Pubmed	Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	12628457
Pubmed	Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	25157794
Pubmed	Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	19615981
Pubmed	Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	38944290
Pubmed	Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	28243714
Pubmed	Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	31202708
Pubmed	Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22246862
Pubmed	Role of megalin and cubilin in the metabolism of vitamin D(3).	LRP2 CUBN	5.36e-06	2	81	2	21595846
Pubmed	Stimulation of the α7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	24298024
Pubmed	Lung eosinophilia induced by house dust mites or ovalbumin is modulated by nicotinic receptor α7 and inhibited by cigarette smoke.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	29975102
Pubmed	α7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	29580318
Pubmed	Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	35479080
Pubmed	P-Rex1 and P-Rex2 RacGEFs and cancer.	PREX1 PREX2	5.36e-06	2	81	2	28710285
Pubmed	[Activation of α7 nAChR improves white fat homeostasis and promotes beige adipogenesis and thermogenesis in obese mice].	CHRFAM7A CHRNA7	5.36e-06	2	81	2	38597441
Pubmed	Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	27471776
Pubmed	Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22688057
Pubmed	α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22820264
Pubmed	Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	33953172
Pubmed	Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	32028688
Pubmed	Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	30089821
Pubmed	Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	20615555
Pubmed	Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	15896732
Pubmed	Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation.	LRP2 CUBN	5.36e-06	2	81	2	23978537
Pubmed	Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	30429582
Pubmed	A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	21501254
Pubmed	α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	21339364
Pubmed	Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	21368056
Pubmed	Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	24289814
Pubmed	Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	19949071
Pubmed	Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	1400473
Pubmed	NNK enhances cell migration through α7-nicotinic acetylcholine receptor accompanied by increased of fibronectin expression in gastric cancer.	FN1 CHRNA7	5.36e-06	2	81	2	21969082
Pubmed	Polymorphisms in LRP2 and CUBN genes and their association with serum vitamin D levels and sleep apnea.	LRP2 CUBN	5.36e-06	2	81	2	38008818
Pubmed	Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	17204496
Pubmed	Differential distribution of cubilin and megalin expression in the mouse embryo.	LRP2 CUBN	5.36e-06	2	81	2	14983511
Pubmed	Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	26937017
Pubmed	Reduction in fibronectin expression and alteration in cell morphology are coincident in NIH3T3 cells expressing a mutant E2F1 transcription factor.	FN1 E2F1	5.36e-06	2	81	2	9367638
Pubmed	α7 nicotinic receptors play a role in regulation of cardiac hemodynamics.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	37017608
Pubmed	Impaired hippocampal theta oscillations in the mice null alpha7 nicotinic acetylcholine receptors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	23795917
Pubmed	Megalin and cubilin in the human gallbladder epithelium.	LRP2 CUBN	5.36e-06	2	81	2	18791690
Pubmed	Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	36603528
Pubmed	Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	20592195
Pubmed	Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	26650489
Pubmed	Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	11854451
Pubmed	Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22848433
Pubmed	Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	23842742
Pubmed	Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	17292512
Pubmed	Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	16650968
Pubmed	Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	35413868
Pubmed	Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	23637989
Pubmed	Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7).	CHRFAM7A CHRNA7	5.36e-06	2	81	2	9782083
Pubmed	High temperature requirement A1 and fibronectin: two possible players in placental tissue remodelling.	HTRA1 FN1	5.36e-06	2	81	2	28076935
Pubmed	Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	24462939
Pubmed	Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	29261717
Pubmed	Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	18199426
Pubmed	Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22490926
Pubmed	Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	36997969
Pubmed	A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	15364017
Pubmed	Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.	PREX1 PREX2	5.36e-06	2	81	2	20694145
Pubmed	Choline, an alpha7 nicotinic acetylcholine receptor agonist, alleviates hyperalgesia in a rat osteoarthritis model.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	23769729
Pubmed	Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	15944242
Pubmed	Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	23270857
Pubmed	Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	18077004
Pubmed	Megalin and cubilin: multifunctional endocytic receptors.	LRP2 CUBN	5.36e-06	2	81	2	11994745
Pubmed	Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	19462340
Pubmed	Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins.	LRP2 CUBN	5.36e-06	2	81	2	10766831
Pubmed	Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	16923147
Pubmed	NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	11790782
Pubmed	A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	33422641
Pubmed	Nicotinic ACh receptor α7 inhibits PDGF-induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	30270436
Pubmed	Activation of α-7 Nicotinic Acetylcholine Receptor Attenuates Cardiac Inflammation Through NLRP3/Caspase-1/IL-18 Pathway.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	34988776
Pubmed	Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	37746145
GeneFamily	C2 and WW domain containing	WWC2 WWC1	4.48e-05	4	50	2	838
GeneFamily	Schlafen family	SLFN13 SLFN11	1.56e-04	7	50	2	1110
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FGD1 PREX1 PREX2	8.06e-04	66	50	3	722
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADAM20 ADAM18	2.52e-03	27	50	2	47
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GALNT14 TENM3 ATRNL1 SYNE2 TMEM151B LRP2 WWC1	3.07e-08	178	79	7	544379f5a6145429762258d426b876bb36c112f5
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALNT14 CRACD TRIM67 TENM3 GRID2 PREX2 STAT5B	5.35e-08	193	79	7	8b77625bf3c87d39767fb391d1beaca4ab02342b
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GALNT14 TENM3 ATRNL1 SYNE2 LRP2 WWC1	5.50e-07	168	79	6	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	Adult-Endothelial-endothelial_cell_of_bronchial_vessel-D175\|Adult / Lineage, Cell type, age group and donor	KIAA1671 MRPL58 PCDH12 PREX2 CHRNA7 LUZP1	7.46e-07	177	79	6	c9f269765c7d5d29caab75910e51645606ed562e
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GALNT14 THSD7A SYNE2 LRP2 CUBN WWC1	1.03e-06	187	79	6	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD THSD7A SLFN11 CHRFAM7A PREX2 CHRNA7	1.03e-06	187	79	6	02105c82a9ba79d2f19e002188377fc3440770c2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KIAA1671 GALNT14 SYNE2 LRP2 CUBN WWC1	1.16e-06	191	79	6	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KIAA1671 GALNT14 SYNE2 LRP2 CUBN WWC1	1.16e-06	191	79	6	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD HTRA1 THSD7A CHRFAM7A PREX2 CHRNA7	1.20e-06	192	79	6	3abee376c37c3646da33ac381aa63d50a01607a6
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALNT14 CRACD TRIM67 TENM3 GRID2 STAT5B	1.24e-06	193	79	6	2c15186d15545804cc262da9137ab825609d4b2c
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRIM67 ABCC8 TMEM151B NBEA AMER3 CHRFAM7A	1.39e-06	197	79	6	27c044833e471a312a572e0b1c83e4bc8a36e896
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC6A2 TRIM67 ABCC8 TMEM151B NBEA CHRFAM7A	1.43e-06	198	79	6	85881637641d8996be2edc65c4bceff0433135e7
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIAA1671 THSD7A RAPGEF1 PCDH12 PREX1 PREX2	1.48e-06	199	79	6	b15304d3d3f6c254969b54a61bee3d9f368840b2
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-B3GAT2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GALNT14 MRC1 CRACD TRIM67 TENM3 STAT5B	1.52e-06	200	79	6	858421b91f5207b7934b5c219752cb9322a3da31
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-MC4R\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CRACD THSD7A SLFN11 CHRFAM7A PREX2 CHRNA7	1.52e-06	200	79	6	c1797542541747b524c9c22c723d24c8d027d486
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-B3GAT2-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GALNT14 MRC1 CRACD TRIM67 TENM3 STAT5B	1.52e-06	200	79	6	a7022762c1d8aedb7b3e9605873b1e68b9907b35
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-MC4R-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CRACD THSD7A SLFN11 CHRFAM7A PREX2 CHRNA7	1.52e-06	200	79	6	a0cc84add181109bb66ba9d49c732e1790222c96
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-B3GAT2--L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GALNT14 MRC1 CRACD TRIM67 TENM3 STAT5B	1.52e-06	200	79	6	2131c8e7fa054b79906eaf60536da892438b09cd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CRACD FN1 ATRNL1 E2F1 IRAG1	1.34e-05	171	79	5	b0373ed8283ee1792b6a490bff93906546978593
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CRACD FN1 ATRNL1 E2F1 IRAG1	1.34e-05	171	79	5	b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell	COVID-19-kidney-PEC\|kidney / Disease (COVID-19 only), tissue and cell type	GALNT14 LAYN TENM3 ATRNL1 LRP2	1.38e-05	172	79	5	36a96714a0eb6ac438648135336c9791881ddadb
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD THSD7A GRID2 CHRFAM7A CHRNA7	1.46e-05	174	79	5	fdadac1eaab2c4a67e4832f0901df22e893add6a
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-ILC\|Multiple_Sclerosis / Disease, Lineage and Cell Type	WWC2 SLFN13 DEPDC7 WWC1 STAT5B	1.46e-05	174	79	5	7c50bf9da37711266cc077eef4e54b58463f1d37
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD THSD7A CHRFAM7A PREX2 CHRNA7	1.59e-05	177	79	5	fdab7b7ddfb06f913b8224c0c80574dc3cf4cbd4
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	THSD7A PLPPR4 TENM3 SLFN11 PCDH12	1.67e-05	179	79	5	cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GALNT14 SYNE2 LRP2 CUBN WWC1	1.72e-05	180	79	5	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIAA1671 GFRAL TNFRSF10D PCDH12 PREX1	1.77e-05	181	79	5	9bfd93cf053beaee806cacdffd7abef02f94aec6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	KIAA1671 DNAH3 LRP2 GRID2 CUBN	1.77e-05	181	79	5	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD THSD7A CHRFAM7A PREX2 CHRNA7	1.77e-05	181	79	5	2f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD THSD7A CHRFAM7A PREX2 CHRNA7	1.81e-05	182	79	5	7dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD HTRA1 THSD7A PREX2 CHRNA7	1.81e-05	182	79	5	420a8fd30543e37a66ba0786215d056d308660d0
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GALNT14 THSD7A LRP2 CUBN WWC1	1.81e-05	182	79	5	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GALNT14 SYNE2 LRP2 CUBN WWC1	1.86e-05	183	79	5	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD THSD7A CHRFAM7A PREX2 CHRNA7	1.86e-05	183	79	5	e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD THSD7A CHRFAM7A PREX2 CHRNA7	1.86e-05	183	79	5	5e361be3ae3fe05098968e58427630127bd12675
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	GALNT14 SYNE2 LRP2 CUBN WWC1	1.91e-05	184	79	5	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD THSD7A CHRFAM7A PREX2 CHRNA7	1.96e-05	185	79	5	027020754dbf71b0034791f9a34ae795e3b85f81
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD THSD7A CHRFAM7A PREX2 CHRNA7	1.96e-05	185	79	5	08fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD HTRA1 THSD7A CHRFAM7A CHRNA7	1.96e-05	185	79	5	cefd81adb480c027545a5c78dcd05669783717f4
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HTRA1 THSD7A CHRFAM7A PREX2 CHRNA7	1.96e-05	185	79	5	bdfa8c284bbc5e85c806327fbb7778cf16242a38
ToppCell	COVID-19-kidney-Mito-rich_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GALNT14 SYNE2 LRP2 CUBN WWC1	1.96e-05	185	79	5	1bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD HTRA1 CHRFAM7A PREX2 CHRNA7	1.96e-05	185	79	5	4c42bd3cd72f91f4d4ebb849069a03761a2cd662
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIAA1671 THSD7A PCDH12 PREX1 PREX2	1.96e-05	185	79	5	602536a3308a848f106adcb0a83530997440c8f4
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-6_VIP_RCN1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A2 CRACD HTRA1 CHRFAM7A CHRNA7	1.96e-05	185	79	5	538db481c82b02e5d3b8e03b166f754cc936901e
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	CRACD VPS13D WAPL IRAG1 LUZP1	2.01e-05	186	79	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KIAA1671 SYNE2 LRP2 CUBN WWC1	2.01e-05	186	79	5	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD HTRA1 THSD7A CHRFAM7A CHRNA7	2.07e-05	187	79	5	ae2ee6f8e5c37cb88a67f3e742cf86e57657bfaf
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALNT14 CRACD TRIM67 TENM3 GRID2	2.07e-05	187	79	5	85f1678338a47d91e296f0620d4887f057eb7e70
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KIAA1671 GALNT14 LRP2 CUBN WWC1	2.07e-05	187	79	5	3ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	KIAA1671 THSD7A SYNE2 RAPGEF1 PREX2	2.07e-05	187	79	5	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIAA1671 THSD7A PCDH12 PREX1 PREX2	2.07e-05	187	79	5	25efb82afe863a853ecdd781ad89026c993aaa67
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIAA1671 GFRAL TNFRSF10D PCDH12 PREX1	2.17e-05	189	79	5	9e58411e51019ca59e78d3e737d65d2bcbbea2be
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	KIAA1671 THSD7A FN1 RAPGEF1 TNFRSF10D	2.17e-05	189	79	5	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 SYNE2 LRP2 CUBN WWC1	2.17e-05	189	79	5	28b502611829e4a24caff2562545c7db97686099
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	GALNT14 SYNE2 LRP2 CUBN WWC1	2.17e-05	189	79	5	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Artery\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIAA1671 CRACD THSD7A FN1 PREX2	2.23e-05	190	79	5	aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CRACD FN1 TENM3 ATRNL1 IRAG1	2.23e-05	190	79	5	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	COVID-19-Heart-EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	THSD7A SYNE2 RAPGEF1 IRAG1 PREX2	2.23e-05	190	79	5	a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIAA1671 FN1 RAPGEF1 PREX1 PREX2	2.29e-05	191	79	5	b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD HTRA1 THSD7A CHRFAM7A CHRNA7	2.29e-05	191	79	5	764c3a8829ae1253a0790744138266e81fc075ec
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A2 CRACD HTRA1 THSD7A PREX2	2.29e-05	191	79	5	06760c3bb40e4f66879a5f5e09c9abfce4ebbba3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CRACD FN1 TENM3 ATRNL1 IRAG1	2.29e-05	191	79	5	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CRACD FN1 TENM3 ATRNL1 IRAG1	2.29e-05	191	79	5	bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell	RA-09._Endothelium_I\|World / Chamber and Cluster_Paper	KIAA1671 SYNE2 RAPGEF1 TNFRSF10D PREX2	2.29e-05	191	79	5	c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALNT14 CRACD TRIM67 TENM3 STAT5B	2.29e-05	191	79	5	9c0ee270209b02043393416ecc9a81ddedfbb8b6
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIAA1671 THSD7A PCDH12 PREX1 PREX2	2.34e-05	192	79	5	1f35efb0765e05f7f9c881849953bef3965be25a
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALNT14 CRACD TRIM67 TENM3 GRID2	2.40e-05	193	79	5	d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 THSD7A NBEA PREX2 LUZP1	2.40e-05	193	79	5	2483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GALNT14 THSD7A LRP2 CUBN WWC1	2.40e-05	193	79	5	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALNT14 CRACD TRIM67 TENM3 GRID2	2.40e-05	193	79	5	3ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALNT14 CRACD TRIM67 TENM3 GRID2	2.40e-05	193	79	5	e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALNT14 CRACD TRIM67 TENM3 GRID2	2.40e-05	193	79	5	658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GALNT14 SYNE2 LRP2 CUBN WWC1	2.46e-05	194	79	5	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CRACD FN1 TENM3 ATRNL1 IRAG1	2.52e-05	195	79	5	49c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTRA1 TRIM67 FGD1 CUBN IRAG1	2.52e-05	195	79	5	d32716a12014522492becbde1088dc1106308490
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CRACD FN1 TENM3 ATRNL1 IRAG1	2.52e-05	195	79	5	dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCell	droplet-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTRA1 TRIM67 FGD1 CUBN IRAG1	2.52e-05	195	79	5	b913d5df50c88a3a255f516a1aa42419c6701e1e
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC6A2 TRIM67 ABCC8 TMEM151B NBEA	2.52e-05	195	79	5	5a6a5048af638872700b76b7c71a8fa3fb8d3772
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD HTRA1 TRIM67 TENM3 PREX2	2.59e-05	196	79	5	7af6c5147ac859353504d19727dbe24f63a29dd4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 TENM3 ATRNL1 IRAG1 PREX2	2.59e-05	196	79	5	3a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 TENM3 ATRNL1 IRAG1 PREX2	2.59e-05	196	79	5	bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIAA1671 THSD7A PCDH12 PREX1 PREX2	2.65e-05	197	79	5	98e34e8612f111bb667a574de1faaa785d318ca4
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	THSD7A CUBN CEACAM20 GFAP PREX2	2.65e-05	197	79	5	ad4a3b5da2190be9495382a2952991e1de9f190d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 TENM3 ATRNL1 IRAG1 PREX2	2.65e-05	197	79	5	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	metastatic_Brain-Endothelial_cells\|metastatic_Brain / Location, Cell class and cell subclass	HTRA1 LAYN THSD7A CUBN PCDH12	2.72e-05	198	79	5	97ef7946ef11ac93318c1dd46b548dc01e5a6aba
ToppCell	Transplant_Alveoli_and_parenchyma-Endothelial\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	LAYN THSD7A SYNE2 PCDH12 PREX2	2.72e-05	198	79	5	56b746e5791b47fe33a7872f0942ae0747b13d4a
ToppCell	metastatic_Brain-Endothelial_cells-Tumor_ECs\|metastatic_Brain / Location, Cell class and cell subclass	HTRA1 LAYN THSD7A CUBN PCDH12	2.72e-05	198	79	5	5e274f29cc796dae7d64d6035e904816c25f9914
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MRC1 FN1 GLIPR2 E2F1 SLFN11	2.78e-05	199	79	5	e1190b1c2d21fed313bb58e24d0e6365de6e6599
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LAYN TNFRSF10D CUBN PCDH12 CHRFAM7A	2.78e-05	199	79	5	63c01e8961f48ed1bed4ab619cacf318cd6de7b9
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CRACD TRIM67 THSD7A TENM3 GRID2	2.85e-05	200	79	5	a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-TSPAN12-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CRACD HTRA1 CHRFAM7A PREX2 CHRNA7	2.85e-05	200	79	5	523d799eb315b33b77e02d5b7db63dad8450c4e1
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CRACD HTRA1 CHRFAM7A PREX2 CHRNA7	2.85e-05	200	79	5	9f21e4e0913d8ef95a3f771dff0abaad8fe1d9f2
ToppCell	Neuronal-Inhibitory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CRACD HTRA1 TRIM67 THSD7A PREX2	2.85e-05	200	79	5	9ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CRACD TRIM67 THSD7A TENM3 GRID2	2.85e-05	200	79	5	33b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-TSPAN12\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CRACD HTRA1 CHRFAM7A PREX2 CHRNA7	2.85e-05	200	79	5	e5cef95e563a6e793ade190ce88c999bfa0af460
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Artery\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	THSD7A FN1 SYNE2 PREX2 LUZP1	2.85e-05	200	79	5	77ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CRACD HTRA1 CUBN CHRFAM7A CHRNA7	2.85e-05	200	79	5	8a8f9d9e5ffab3f736c4bd0a5bb616d442d137d1
ToppCell	Neuronal-Inhibitory-iA\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CRACD HTRA1 THSD7A PREX2 CHRNA7	2.85e-05	200	79	5	5ef4a3dc18a44292184a59ced916183c0699b01e
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-T/NK-ILC\|Multiple_Sclerosis / Disease, condition lineage and cell class	WWC2 SLFN13 DEPDC7 WWC1 STAT5B	2.85e-05	200	79	5	ab9bdc9365cbdffe4ed246ce0c8a008a390e387e
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-PCDH20-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CRACD HTRA1 CHRFAM7A PREX2 CHRNA7	2.85e-05	200	79	5	1d67c5d2c617749b521e70879950dea2c9d076d6
Disease	Spina Bifida, Open	GFAP CHRNA7	6.90e-06	2	78	2	C0917813
Disease	Spina Bifida Cystica	GFAP CHRNA7	6.90e-06	2	78	2	C0037917
Disease	Proteinuria	LRP2 CUBN SMG6	7.90e-06	15	78	3	HP_0000093
Disease	Colorectal Carcinoma	DNAH3 FN1 ABCC8 LRP2 GRID2 STK32C CUBN PREX2 SLC12A5	9.79e-05	702	78	9	C0009402
Disease	cognitive disorder (implicated_via_orthology)	CHRFAM7A CHRNA7	1.03e-04	6	78	2	DOID:1561 (implicated_via_orthology)
Disease	rheumatoid arthritis (biomarker_via_orthology)	CHRFAM7A CHRNA7	1.03e-04	6	78	2	DOID:7148 (biomarker_via_orthology)
Disease	X-24747 measurement	ACAD11 FBF1	1.91e-04	8	78	2	EFO_0022135
Disease	Seizures	SLC6A2 NBEA GFAP CHRNA7 SLC12A5	2.86e-04	218	78	5	C0036572
Disease	migraine disorder	HTRA1 WAPL TRPM8 NBEA IRAG1 SMG6	3.71e-04	357	78	6	MONDO_0005277
Disease	Bardet-Biedl syndrome (implicated_via_orthology)	TBC1D32 BBS7	3.74e-04	11	78	2	DOID:1935 (implicated_via_orthology)
Disease	nicotine dependence (implicated_via_orthology)	CHRFAM7A CHRNA7	4.48e-04	12	78	2	DOID:0050742 (implicated_via_orthology)
Disease	irritable bowel syndrome symptom measurement	TRIM67 CHRFAM7A CHRNA7	4.94e-04	58	78	3	EFO_0021536
Disease	Alpha ketoglutarate measurement	TENM3 KCNV2	8.08e-04	16	78	2	EFO_0010457
Disease	nucleotide measurement	SYNE2 STK39 STK32C	9.67e-04	73	78	3	EFO_0010513
Disease	migraine disorder, systolic blood pressure	IRAG1 SMG6	1.03e-03	18	78	2	EFO_0006335, MONDO_0005277
Disease	lung non-small cell carcinoma (is_marker_for)	HTRA1 E2F1 PREX2 STAT5B	1.07e-03	169	78	4	DOID:3908 (is_marker_for)
Disease	coronary artery disease	CRACD HTRA1 LAYN THSD7A FN1 ACAD11 FBF1 IRAG1 PREX1 SMG6	1.17e-03	1194	78	10	EFO_0001645
Disease	X-24309 measurement	ACAD11 FBF1	1.27e-03	20	78	2	EFO_0800872
Disease	blood pressure	STK39 PREX1	1.54e-03	22	78	2	EFO_0004325
Disease	Attention Deficit Disorder	DRD5 FGD1	1.54e-03	22	78	2	C0041671
Disease	Minimal Brain Dysfunction	DRD5 FGD1	1.54e-03	22	78	2	C1321905
Disease	migraine disorder, Headache	HTRA1 TRPM8 IRAG1	1.55e-03	86	78	3	HP_0002315, MONDO_0005277
Disease	Bipolar Disorder	SLC6A2 DRD5 THSD7A CHRFAM7A GFAP CHRNA7	1.66e-03	477	78	6	C0005586
Disease	Attention deficit hyperactivity disorder	DRD5 FGD1	1.83e-03	24	78	2	C1263846
Disease	neuroimaging measurement	MRC1 SLAMF6 ACAD11 CHCHD7 IRAG1 GFAP WWC1 LUZP1 SMG6	2.02e-03	1069	78	9	EFO_0004346
Disease	blood rubidium measurement	ATP6V1C1 PREX1	2.15e-03	26	78	2	EFO_0021529
Disease	pancreatic ductal adenocarcinoma (is_marker_for)	GLIPR2 E2F1	2.32e-03	27	78	2	DOID:3498 (is_marker_for)
Disease	Visual seizure	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0270824
Disease	Epileptic drop attack	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0270846
Disease	Generalized seizures	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0234533
Disease	Clonic Seizures	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0234535
Disease	Vertiginous seizure	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0422855
Disease	Gustatory seizure	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0422854
Disease	Seizures, Somatosensory	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0422850
Disease	Olfactory seizure	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0422853
Disease	Seizures, Auditory	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0422852
Disease	Generalized Absence Seizures	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C4505436
Disease	Convulsive Seizures	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0751494
Disease	Seizures, Sensory	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0751496
Disease	Jacksonian Seizure	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0022333
Disease	Non-epileptic convulsion	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0751056
Disease	Atonic Absence Seizures	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0751123
Disease	Complex partial seizures	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0149958
Disease	Single Seizure	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C0751110
Disease	Epileptic Seizures	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C4317109
Disease	Nonepileptic Seizures	SLC6A2 CHRNA7 SLC12A5	2.46e-03	101	78	3	C3495874
Disease	Tonic Seizures	SLC6A2 CHRNA7 SLC12A5	2.53e-03	102	78	3	C0270844
Disease	Absence Seizures	SLC6A2 CHRNA7 SLC12A5	2.53e-03	102	78	3	C4316903
Disease	Convulsions	SLC6A2 CHRNA7 SLC12A5	2.53e-03	102	78	3	C4048158

Protein segments in the cluster

Peptide	Gene	Start	Entry
YSASTQDQRCRDRVQ	AMER3	736	Q8N944
CQGDIARYREQASDT	SMG6	731	Q86US8
SNDNFLLATYRCQAD	BBS7	436	Q8IWZ6
DASTRCLDENNYDRE	CHCHD7	21	Q9BUK0
AVQERAARSQCTYSN	CPN2	471	P22792
YRTDNCSDSDSSLNQ	TBC1D32	151	Q96NH3
QDARSASQSCYQEIN	ADAM20	521	O43506
SCNRENAEYNRNSSV	ADAM18	716	Q9Y3Q7
YQCEARDALLSQRSD	CEACAM20	136	Q6UY09
RREQLTEYNGTDNCT	GKAP1	226	Q5VSY0
YCQRIDQRDYSNNTE	DEPDC7	451	Q96QD5
RYIANRFRCQDESEA	CHRNA7	441	P36544
ATNIECSIQRDEDSY	ACAD11	516	Q709F0
DVNAENCDSSLNRTY	DRD5	211	P21918
DNRAYNCREAESTYR	PCDH12	746	Q9NPG4
DCAETQEACRSLQNY	KAT6B	1561	Q8WYB5
QEACRSLQNYTRADQ	KAT6B	1566	Q8WYB5
SSFREEDNTYRCRNV	AP1G1	36	O43747
DQYDCSRDQRSTSVD	KIAA1671	1586	Q9BY89
VQACFSRSREYQLND	GNAI3	136	P08754
SQYVCRLNRSDSDSS	WWC1	936	Q8IX03
REEKQSNSTACQDLY	LAYN	111	Q6UX15
SQSDALRACFERNLY	DUX5	56	Q96PT3
FRNDSYTLESRINQA	IRAG1	536	Q9Y6F6
CGLTRSNRNDDYTLS	GRID2	131	O43424
LRNESCSENYTTDFI	PFKP	636	Q01813
GYDENQNCTRRTCSE	LRP2	2981	P98164
EANDYRRQLQSLTCD	GFAP	281	P14136
RYIANRFRCQDESEA	CHRFAM7A	351	Q494W8
LYAFNQRESERISSN	GALNT14	76	Q96FL9
TEADSQNYQRCLETG	BECN2	136	A8MW95
QCQSDSSQNYIEVRD	CUBN	756	O60494
ARYLSQCQEAEQARA	FBF1	656	Q8TES7
SDANTYANLCQLRAA	HTRA1	121	Q92743
EDTDSQRLAYVTCQD	E2F1	236	Q01094
VDVNRDTNTSICNQY	DNAH3	691	Q8TD57
TNNCTYLREQCLRDA	GFRAL	21	Q6UXV0
NREAQQYSEALASTR	GLIPR2	36	Q9H4G4
TSRNRCNDQDTRTSY	FN1	226	P02751
CNDQDTRTSYRIGDT	FN1	231	P02751
RTNYSLRFNCDQQAE	CRACD	851	Q6ZU35
INQNCDSARTSDDRL	IGFL1	91	Q6UW32
TSESSRYQFRNLADC	MRPL58	136	Q14197
GDACLRVNSSRENYD	ATRNL1	756	Q5VV63
SQSDALRACFERNLY	DUX3	56	Q96PT4
RDYTRNASNLERNDL	LUZP1	226	Q86V48
LREQDAEGQDYCTRT	SLFN13	476	Q68D06
QFCKRSYSDLDSNRE	PPRC1	1621	Q5VV67
SQNYSVRGECEEASR	MIER2	51	Q8N344
NATCDEYFTRNNVTE	SLC12A5	351	Q9H2X9
TCNNENAYLTTIEDR	MRC1	531	P22897
DNNCYRDALLTSSIN	SLC6A2	336	P23975
RSSNVLSEDQDSYLC	ATP6V1C1	211	P21283
RISSEQDYTCIAENA	SLAMF6	186	Q96DU3
YDQNGRLVETSRCNS	THSD7A	1006	Q9UPZ6
SEEDYSCTQANNFAR	SYNE2	6856	Q8WXH0
ASVEAENAYLCQRAR	TMEM151B	241	Q8IW70
AEFESQCAQYAADRR	NBEA	2001	Q8NFP9
SRSRQLSLCDDYEEQ	KCNV2	131	Q8TDN2
LVYDNNRSNRVCTDC	FGD1	771	P98174
YRDSYSECNSNRDSV	PREX1	1166	Q8TCU6
LREQDAEGQDYCTRT	SLFN11	476	Q7Z7L1
ALSTRDNENQCDYRT	SGO2	671	Q562F6
ENTRNDYSGEILNNC	STAT5B	386	P51692
SRDSSQSENDYLQDC	STK32C	411	Q86UX6
TNYQRLCEAFDAQVR	ABCC8	261	Q09428
AEDNARNETLSNRYL	TNFRSF10D	271	Q9UBN6
YELNDLNRDSESCES	PLPPR4	661	Q7Z2D5
DNQTATCSSYDDRVV	TRIM67	626	Q6ZTA4
VSQQACTRDRSLDYS	ZNF778	186	Q96MU6
NQYICRLNRSDSDSS	WWC2	1011	Q6AWC2
RQDFDVDCYAQRRLS	RAPGEF1	321	Q13905
QQYNRAEDSICLADS	WAPL	896	Q7Z5K2
YCEDAESNRQLESTE	PHF3	401	Q92576
RRYTNSSADNEECRV	TENM3	21	Q9P273
TISNRDSYSDCNSNR	PREX2	1101	Q70Z35
QVCAEALAQRTYSDD	XPOT	36	O43592
LEDNEDQSRRSYRCD	ZNF236	956	Q9UL36
SNRDTLIRNCDAEGY	TRPM8	221	Q7Z2W7
CVFAEESDLSRQYQR	GTF3C1	431	Q12789
NEDYREASSCAVNLV	STK39	441	Q9UEW8
NVDYNASSETLRCEA	VTCN1	156	Q7Z7D3
SSYNRVNRSIDVDFN	VPS13D	1801	Q5THJ4