Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	EGF	EYS PAMR1 JAG1 CNTNAP1 UMOD ITGB3	1.55e-05	126	79	6	PF00008
Domain	EGF_1	EYS PAMR1 JAG1 CNTNAP1 UMOD C6 ITGB3	1.02e-04	255	79	7	PS00022
Domain	EGF-like_CS	EYS PAMR1 JAG1 CNTNAP1 UMOD C6 ITGB3	1.18e-04	261	79	7	IPR013032
Domain	EGF_2	EYS PAMR1 JAG1 CNTNAP1 UMOD C6 ITGB3	1.30e-04	265	79	7	PS01186
Domain	TAAR_fam	TAAR9 TAAR6	3.66e-04	7	79	2	IPR009132
Domain	EGF_3	EYS PAMR1 JAG1 CNTNAP1 UMOD C6	4.81e-04	235	79	6	PS50026
Domain	Man6P_isomerase_rcpt-bd_dom	ELAPOR2 IGF2R	4.87e-04	8	79	2	IPR009011
Domain	EGF-like_dom	EYS PAMR1 JAG1 CNTNAP1 UMOD C6	6.52e-04	249	79	6	IPR000742
Domain	APOBEC_N	APOBEC3D APOBEC3B	1.13e-03	12	79	2	PF08210
Domain	APOBEC_N	APOBEC3D APOBEC3B	1.13e-03	12	79	2	IPR013158
Domain	Peptidase_M1	NPEPPS TAF2	1.34e-03	13	79	2	PF01433
Domain	Peptidase_M1_N	NPEPPS TAF2	1.34e-03	13	79	2	IPR014782
Domain	Sushi	PAMR1 C4BPA C6	1.39e-03	52	79	3	PF00084
Domain	CCP	PAMR1 C4BPA C6	1.55e-03	54	79	3	SM00032
Domain	APOBEC/CMP_deaminase_Zn-bd	APOBEC3D APOBEC3B	1.56e-03	14	79	2	IPR016192
Domain	SUSHI	PAMR1 C4BPA C6	1.72e-03	56	79	3	PS50923
Domain	EGF_CA	EYS PAMR1 JAG1 UMOD	1.78e-03	122	79	4	SM00179
Domain	Sushi_SCR_CCP_dom	PAMR1 C4BPA C6	1.81e-03	57	79	3	IPR000436
Domain	EGF-like_Ca-bd_dom	EYS PAMR1 JAG1 UMOD	1.89e-03	124	79	4	IPR001881
Domain	TLC	CERS5 TLCD3A	2.04e-03	16	79	2	PS50922
Domain	TLC	CERS5 TLCD3A	2.04e-03	16	79	2	SM00724
Domain	TRAM_LAG1_CLN8	CERS5 TLCD3A	2.04e-03	16	79	2	PF03798
Domain	TLC-dom	CERS5 TLCD3A	2.04e-03	16	79	2	IPR006634
Domain	Cytidine_deaminase-like	APOBEC3D APOBEC3B	2.31e-03	17	79	2	IPR016193
Domain	CYT_DCMP_DEAMINASES_1	APOBEC3D APOBEC3B	2.31e-03	17	79	2	PS00903
Domain	CMP_dCMP_Zn-bd	APOBEC3D APOBEC3B	2.31e-03	17	79	2	IPR002125
Domain	EGF	EYS PAMR1 JAG1 CNTNAP1 UMOD	3.20e-03	235	79	5	SM00181
Domain	USP_1	USP31 USPL1 USP47	3.25e-03	70	79	3	PS00972
Domain	USP_2	USP31 USPL1 USP47	3.39e-03	71	79	3	PS00973
Domain	USP_3	USP31 USPL1 USP47	3.52e-03	72	79	3	PS50235
Domain	USP_dom	USP31 USPL1 USP47	3.52e-03	72	79	3	IPR028889
Domain	Peptidase_C19_UCH	USP31 USPL1 USP47	3.52e-03	72	79	3	IPR001394
Domain	RHODANESE_3	TSTD2 TBC1D23	4.22e-03	23	79	2	PS50206
Domain	Growth_fac_rcpt_	ELAPOR2 EYS JAG1 UMOD	4.33e-03	156	79	4	IPR009030
Domain	Rhodanese-like_dom	TSTD2 TBC1D23	4.59e-03	24	79	2	IPR001763
Domain	Rhodanese	TSTD2 TBC1D23	4.59e-03	24	79	2	PF00581
Domain	-	TSTD2 TBC1D23	4.59e-03	24	79	2	3.40.250.10
Domain	K_chnl_volt-dep_Kv	KCNB1 KCNS2	5.79e-03	27	79	2	IPR003968
Domain	hEGF	EYS JAG1	6.22e-03	28	79	2	PF12661
Pubmed	A truncated, activin-induced Smad3 isoform acts as a transcriptional repressor of FSHβ expression in mouse pituitary.	FSHB SMAD3	5.49e-06	2	82	2	21664424
Pubmed	Murine Leukemia Virus P50 Protein Counteracts APOBEC3 by Blocking Its Packaging.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	32641479
Pubmed	APOBEC3 deletion increases the risk of breast cancer: a meta-analysis.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	27602762
Pubmed	A novel role for APOBEC3: susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	22691411
Pubmed	Studies on the restriction of murine leukemia viruses by mouse APOBEC3.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	22666481
Pubmed	APOBEC3 deletion polymorphism is associated with epithelial ovarian cancer risk among Chinese women.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	24577894
Pubmed	APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	16648136
Pubmed	Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	23533681
Pubmed	Spontaneous recovery from Friend retrovirus-induced leukemia. Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	1541833
Pubmed	In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	27356895
Pubmed	IFN-α treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	23315078
Pubmed	Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	25589647
Pubmed	Regulation of dendritic cell differentiation in bone marrow during emergency myelopoiesis.	JAG1 ITGB3	1.64e-05	3	82	2	23833236
Pubmed	Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	23671100
Pubmed	Structural perspectives on HIV-1 Vif and APOBEC3 restriction factor interactions.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	31518043
Pubmed	APOBEC3 signature mutations in chronic lymphocytic leukemia.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	24840555
Pubmed	Requirement for CD4(+) T cells in the Friend murine retrovirus neutralizing antibody response: evidence for functional T cells in genetic low-recovery mice.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	9765497
Pubmed	Biochemical and biological studies of mouse APOBEC3.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	24453360
Pubmed	Activin B induces human endometrial cancer cell adhesion, migration and invasion by up-regulating integrin β3 via SMAD2/3 signaling.	ITGB3 SMAD3	1.64e-05	3	82	2	26384307
Pubmed	APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcription.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	23449789
Pubmed	The roles of THY1 and integrin beta3 in cell adhesion during theca cell layer formation and the effect of follicle-stimulating hormone on THY1 and integrin beta3 localization in mouse ovarian follicles.	FSHB ITGB3	1.64e-05	3	82	2	21228213
Pubmed	APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	18434399
Pubmed	Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells.	FSHB SMAD3	1.64e-05	3	82	2	14701940
Pubmed	Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	19153238
Pubmed	Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	18772436
Pubmed	Mouse Sertoli cells sustain de novo generation of regulatory T cells by triggering the notch pathway through soluble JAGGED1.	JAG1 SMAD3	1.64e-05	3	82	2	24478388
Pubmed	Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	18786991
Pubmed	Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	286744
Pubmed	Host restriction of murine gammaherpesvirus 68 replication by human APOBEC3 cytidine deaminases but not murine APOBEC3.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	24725948
Pubmed	The glycosylated Gag protein of a murine leukemia virus inhibits the antiretroviral function of APOBEC3.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	20702647
Pubmed	Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	20980520
Pubmed	Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	284359
Pubmed	Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	20617165
Pubmed	Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	31801862
Pubmed	Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	39208378
Pubmed	Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	31943071
Pubmed	Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	20566830
Pubmed	Chromosome mapping of Rfv3, a host resistance gene to Friend murine retrovirus.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	7884913
Pubmed	N-linked glycosylation protects gammaretroviruses against deamination by APOBEC3 proteins.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	25505062
Pubmed	Molecular analysis of γ1, γ3, and α class switch recombination junctions in APOBEC3-deficient mice using high-throughput sequencing.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	31595054
Pubmed	Role of APOBEC3 in genetic diversity among endogenous murine leukemia viruses.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	17967065
Pubmed	Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	20335265
Pubmed	Deaminase-Dead Mouse APOBEC3 Is an In Vivo Retroviral Restriction Factor.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	29593034
Pubmed	Mouse APOBEC3 interferes with autocatalytic cleavage of murine leukemia virus Pr180gag-pol precursor and inhibits Pr65gag processing.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	31830125
Pubmed	Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	21998583
Pubmed	Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	38115583
Pubmed	Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion.	JAG1 SMAD3	1.64e-05	3	82	2	38092725
Pubmed	Genome-wide association study of kidney function decline in individuals of European descent.	GALNT11 UMOD	1.64e-05	3	82	2	25493955
Pubmed	Effects of zidovudine on Friend virus complex infection in Rfv-3r/s genotype-containing mice used as a model for HIV infection.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	2157836
Pubmed	Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	35458563
Pubmed	Two genetic determinants acquired late in Mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	22275865
Pubmed	Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	293683
Pubmed	Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	19150103
Pubmed	Initial sequencing and comparative analysis of the mouse genome.	APOBEC3D APOBEC3B	1.64e-05	3	82	2	12466850
Pubmed	FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoter.	FSHB SMAD3	3.28e-05	4	82	2	22294749
Pubmed	Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	18983852
Pubmed	APOBEC3 regulates keratinocyte differentiation and expression of Notch3.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	31400166
Pubmed	Mannose 6-phosphate/insulin-like growth factor 2 receptor limits cell invasion by controlling alphaVbeta3 integrin expression and proteolytic processing of urokinase-type plasminogen activator receptor.	IGF2R ITGB3	3.28e-05	4	82	2	19037107
Pubmed	Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	23725696
Pubmed	APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	21985787
Pubmed	APOBEC3A functions as a restriction factor of human papillomavirus.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	25355878
Pubmed	Human and murine APOBEC3s restrict replication of koala retrovirus by different mechanisms.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	26253512
Pubmed	Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	17020885
Pubmed	Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in friend virus-infected mice.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	20375169
Pubmed	APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	21147467
Pubmed	Mice deficient in APOBEC2 and APOBEC3.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	16055735
Pubmed	The incorporation of APOBEC3 proteins into murine leukemia viruses.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	18572219
Pubmed	Restriction of foamy viruses by APOBEC cytidine deaminases.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	16378963
Pubmed	Multifaceted HIV-1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	32893454
Pubmed	Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	15269786
Pubmed	Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	24821801
Pubmed	Small molecular compounds inhibit HIV-1 replication through specifically stabilizing APOBEC3G.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	20363737
Pubmed	Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	29343743
Pubmed	APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	15674295
Pubmed	Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	21873525
Pubmed	APOBEC3 enzymes restrict marginal zone B cells.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	25501566
Pubmed	Restriction by APOBEC3 proteins of endogenous retroviruses with an extracellular life cycle: ex vivo effects and in vivo "traces" on the murine IAPE and human HERV-K elements.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	18702815
Pubmed	HIV-1 Vif versus the APOBEC3 cytidine deaminases: an intracellular duel between pathogen and host restriction factors.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	20538015
Pubmed	Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA.	SMU1 USP47	3.28e-05	4	82	2	32377397
Pubmed	The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	38049664
Pubmed	Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	26846717
Pubmed	Vaccinia virus replication is not affected by APOBEC3 family members.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	17052331
Pubmed	Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	28415995
Pubmed	Immunity to retroviral infection: the Friend virus model.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	9223268
Pubmed	Species-specific restriction of apobec3-mediated hypermutation.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	18032489
Pubmed	Reassessment of murine APOBEC1 as a retrovirus restriction factor in vivo.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	25303118
Pubmed	APOBEC3 inhibits mouse mammary tumour virus replication in vivo.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	17259974
Pubmed	HIV restriction by APOBEC3 in humanized mice.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	23555255
Pubmed	The Cytidine Deaminase APOBEC3G Contributes to Cancer Mutagenesis and Clonal Evolution in Bladder Cancer.	APOBEC3D APOBEC3B	3.28e-05	4	82	2	36480186
Pubmed	ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis.	JAG1 UMOD SMAD3	5.41e-05	31	82	3	36445780
Pubmed	Kv2 channel-AMIGO β-subunit assembly modulates both channel function and cell adhesion molecule surface trafficking.	KCNB1 AMIGO2	5.47e-05	5	82	2	34137443
Pubmed	Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein.	APOBEC3D APOBEC3B	5.47e-05	5	82	2	21659520
Pubmed	HIV-1 Vif, APOBEC, and intrinsic immunity.	APOBEC3D APOBEC3B	5.47e-05	5	82	2	18577210
Pubmed	Structural basis of amine odorant perception by a mammal olfactory receptor.	TAAR9 TAAR6	5.47e-05	5	82	2	37225986
Pubmed	IFN-α and lipopolysaccharide upregulate APOBEC3 mRNA through different signaling pathways.	APOBEC3D APOBEC3B	5.47e-05	5	82	2	22972924
Pubmed	The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements.	APOBEC3D APOBEC3B	5.47e-05	5	82	2	18304004
Pubmed	Trace amines: identification of a family of mammalian G protein-coupled receptors.	TAAR9 TAAR6	5.47e-05	5	82	2	11459929
Pubmed	APOBEC3 inhibits DEAD-END function to regulate microRNA activity.	APOBEC3D APOBEC3B	5.47e-05	5	82	2	23890083
Pubmed	Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo.	APOBEC3D APOBEC3B	5.47e-05	5	82	2	24851906
Pubmed	Multiple loci associated with indices of renal function and chronic kidney disease.	JAG1 UMOD	5.47e-05	5	82	2	19430482
Cytoband	8q24.12	TRPS1 TAF2	2.43e-04	13	82	2	8q24.12
GeneFamily	Trace amine receptors	TAAR9 TAAR6	3.23e-04	9	55	2	188
GeneFamily	Apolipoprotein B mRNA editing enzyme catalytic subunits	APOBEC3D APOBEC3B	5.88e-04	12	55	2	406
GeneFamily	Ubiquitin specific peptidases	USP31 USPL1 USP47	6.59e-04	56	55	3	366
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PAMR1 C4BPA C6	6.94e-04	57	55	3	1179
GeneFamily	Potassium voltage-gated channels	KCNB1 KCNS2	6.58e-03	40	55	2	274
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	IGF2R JAG1 ACKR1 ITGB3 BTN3A1	6.82e-03	394	55	5	471
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYADM SLC46A3 NEURL3 ABCA6 PLEKHM3	1.13e-05	159	82	5	3bab00f8fb7d9232538e50f83dd0fd70ddd16819
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-CD45\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYADM SLC46A3 NEURL3 ABCA6 PLEKHM3	1.17e-05	160	82	5	5bec867def73fa8531f8dad611679f4b44f573bd
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A LIPE KCNB1 ABCA6 C6	1.20e-05	161	82	5	a006491c991e6a134be20ad75092a91f3b7c3c91
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	ELAPOR2 MSMO1 OTOGL NPEPPS C4BPA	1.32e-05	164	82	5	beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	ELAPOR2 MSMO1 OTOGL NPEPPS C4BPA	1.32e-05	164	82	5	d005cfd821b87548b075120bffe65a0be9860463
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC5A6 GRIA4 DEPDC5 LANCL2 AMIGO2	1.44e-05	167	82	5	774f3264318b002d0df5d06d41d645366038d0bf
ToppCell	TCGA-Adrenal-Primary_Tumor-Adrenocortical_carcinoma-Usual_Type-4\|TCGA-Adrenal / Sample_Type by Project: Shred V9	LIPE MSMO1 CHEK2 DHX32 APOBEC3B	1.75e-05	174	82	5	15e2b9f46404ff9575e149024b24cb17b50b02b5
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	CRY2 KCNB1 CPEB3 GRIA4 USP47	1.90e-05	177	82	5	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	facs-Lung-Endomucin-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNB1 JAG1 ACKR1 ELOVL7 AMIGO2	1.95e-05	178	82	5	5cc182e6faa7ba5b88378d2c953be29bbbb95a7e
ToppCell	facs-Lung-Endomucin-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNB1 JAG1 ACKR1 ELOVL7 AMIGO2	1.95e-05	178	82	5	f9a16bc3f09c35c7d30e3809da024bc2dcf746ed
ToppCell	TCGA-Head_and_Esophagus-Solid_Tissue_Normal\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	CRY2 CPEB3 FAM3B C6 CA3	2.06e-05	180	82	5	806e2f6138b630b9d7c41df75ec208e0a2298ee0
ToppCell	P28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KCNB1 EMP1 ACKR1 ELOVL7 AMIGO2	2.41e-05	186	82	5	153c8b2fd8a6e2141ca97c626f82e5f081f3180a
ToppCell	droplet-Lung-nan-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNB1 JAG1 EMP1 ACKR1 AMIGO2	2.48e-05	187	82	5	64dd28b23eda7dfb7fd069be2742de7bad0fd87a
ToppCell	droplet-Lung-nan-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNB1 JAG1 EMP1 ACKR1 AMIGO2	2.48e-05	187	82	5	b535d5447bf15e95dcf025a0a455628b956fc857
ToppCell	P15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KCNB1 EMP1 ITGB3 ELOVL7 AMIGO2	2.67e-05	190	82	5	d072bb285bd34d518b958e7c9ad44739c60b359c
ToppCell	droplet-Heart-HEART-1m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A IGF2R TSPAN4 ELOVL7 AMIGO2	2.74e-05	191	82	5	4bfdf44d4402a42530d30c89d94946acdda4321b
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	MYADM LIPE NYNRIN CNTNAP1 SMAD3	3.02e-05	195	82	5	5562665dd3beb70e2358aa32611a337bef5731c1
Disease	remnant cholesterol measurement	IGF2R ABCA6 NYNRIN TRPS1	1.87e-04	108	77	4	EFO_0010815
Disease	free cholesterol measurement	IGF2R ABCA6 NYNRIN TRPS1	2.22e-04	113	77	4	EFO_0008591
Disease	corneodesmosin measurement	TRPS1 ACKR1	2.39e-04	9	77	2	EFO_0801499
Disease	CCL17 measurement	CYP8B1 ACKR1	2.39e-04	9	77	2	EFO_0009414
Disease	phospholipids in medium LDL measurement	IGF2R ABCA6 NYNRIN	2.89e-04	49	77	3	EFO_0022183
Disease	cholesterol in medium LDL measurement	IGF2R ABCA6 NYNRIN	2.89e-04	49	77	3	EFO_0022224
Disease	phospholipids in medium VLDL measurement	IGF2R ABCA6 TRPS1	3.44e-04	52	77	3	EFO_0022154
Disease	total lipids in medium LDL	IGF2R ABCA6 NYNRIN	3.44e-04	52	77	3	EFO_0022180
Disease	total lipids in LDL measurement	IGF2R ABCA6 NYNRIN	3.44e-04	52	77	3	EFO_0022308
Disease	cholesterol in small VLDL measurement	IGF2R ABCA6 TRPS1	3.64e-04	53	77	3	EFO_0022228
Disease	C-C motif chemokine 17 measurement	CYP8B1 ACKR1	4.36e-04	12	77	2	EFO_0008045
Disease	phospholipids in small LDL measurement	IGF2R ABCA6 NYNRIN	5.00e-04	59	77	3	EFO_0022297
Disease	cholesteryl ester measurement	EYS IGF2R ABCA6 NYNRIN TRPS1	5.71e-04	257	77	5	EFO_0010351
Disease	low density lipoprotein cholesterol measurement, physical activity	ABCA6 NYNRIN TRPS1	6.95e-04	66	77	3	EFO_0003940, EFO_0004611
Disease	central nervous system disease (implicated_via_orthology)	SMARCA1 GRIA4	7.88e-04	16	77	2	DOID:331 (implicated_via_orthology)
Disease	household income	NPC1 RBM6 PCNX1 EMP1 ELOVL7	1.21e-03	304	77	5	EFO_0009695
Disease	HMG CoA reductase inhibitor use measurement	ABCA6 TRPS1 PCNX1 SMAD3	1.53e-03	189	77	4	EFO_0009932
Disease	open-angle glaucoma	NPEPPS CHEK2 ITGB3 GLIS1	1.59e-03	191	77	4	EFO_0004190
Disease	CCL11 measurement	CYP8B1 ACKR1	1.64e-03	23	77	2	EFO_0005188
Disease	lipid measurement, lipoprotein measurement	ABCA6 NYNRIN TRPS1	1.71e-03	90	77	3	EFO_0004529, EFO_0004732
Disease	Malignant neoplasm of breast	SEMA3A LIPE OTOGL JAG1 CHEK2 TSPAN4 DHX32 KLHDC7A APOBEC3B	1.90e-03	1074	77	9	C0006142
Disease	corpus callosum mid-anterior volume measurement	JAG1 TAAR6	2.26e-03	27	77	2	EFO_0010297
Disease	corpus callosum volume measurement	SEMA3A JAG1 RBM6	2.30e-03	100	77	3	EFO_0010299
Disease	lumbar disc degeneration	EYS SMAD3	2.43e-03	28	77	2	EFO_0004994
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	ABCA6 NYNRIN TRPS1	2.44e-03	102	77	3	EFO_0004329, EFO_0004611
Disease	free cholesterol measurement, very low density lipoprotein cholesterol measurement	IGF2R ABCA6 NYNRIN TRPS1	2.45e-03	215	77	4	EFO_0008317, EFO_0008591
Disease	non-high density lipoprotein cholesterol measurement	NPC1 IGF2R ABCA6 NPEPPS NYNRIN TRPS1 SMAD3	2.60e-03	713	77	7	EFO_0005689

Protein segments in the cluster

Peptide	Gene	Start	Entry
ACCAKYTSDDFWYRA	TDRD1	996	Q9BXT4
CNSDGEWVYNTFCIY	C4BPA	96	P04003
SCLFPACRDYWTYQG	CA3	181	P07451
YQSWDDFICYCELTG	CNTNAP1	556	P78357
TARLCYFWDTDYQEG	APOBEC3D	316	Q96AK3
FEYCWDTFVYRQGCP	APOBEC3B	341	Q9UH17
ERFNWHYCVLGCESF	BTN3A1	376	O00481
CLAYGGSDVSRCFYW	ACTR8	306	Q9H981
CWDGYGEFSCTLTKY	ABCA6	156	Q8N139
SALCSLGYCVWYGSA	ACKR1	126	Q16570
VCDCSLYSLLVFWYR	AMIGO2	231	Q86SJ2
DNYWFGRDKSCEYCF	CHEK2	111	O96017
SSSEYCVEKWCRDYF	DHX32	561	Q7L7V1
YLCIFCYGIRFLWSS	CERS5	151	Q8N5B7
YYYSWSFACACAAFI	CACNG1	176	Q06432
CWCLDEANYIYAGLA	RFWD3	546	Q6PCD5
RCFGCAVIEDTWHYF	MSMO1	141	Q15800
RLEWCSCYYHGNFSL	DEPDC5	1366	O75140
GYSYILGWICFCFSF	EMP1	131	P54849
YSCLCTLGWVGRYCE	EYS	2956	Q5T1H1
YRACKFAEWCLDYGA	LANCL2	391	Q9NS86
WNCFVFLYDTDRGYS	GRIA4	151	P48058
WYSGRSDAGCLYELT	FBXO2	206	Q9UK22
SFCVIYLNWIEYCSS	PCNX1	1761	Q96RV3
VRYFCYGCLFTSATW	GALNT11	6	Q8NCW6
EYWGINEFFIDSCCS	KCNS2	106	Q9ULS6
YCSTDLYSLWSAVGC	RSKR	186	Q96LW2
DVSCSRSHAYYVCAW	MYADM	276	Q96S97
GFASWIEYLCVDHCF	NPEPPSL1	376	A6NEC2
WYYCSSCHVDDSFLI	PLEKHM3	536	Q6ZWE6
FASLCAWYSGYLLAE	FAM3B	16	P58499
INTTWCAGYCYTRDL	FSHB	41	P01225
DGCTFYFLWESAEAC	ELAPOR2	861	A8MWY0
ERGSWSCELCYFKYQ	MARCHF9	146	Q86YJ5
FSQSCVWYGECGIAY	NPC1	21	O15118
RCLYYTSFSLELCWQ	HHAT	176	Q5VTY9
YWGIDEIYLESCCQA	KCNB1	121	Q14721
SCGYDTCYDWEKCSA	C6	861	P13671
FGCLSCRLFYYRLWD	CRY2	276	Q49AN0
VTCLQYYCEYCWASI	CPEB3	656	Q8NE35
YYCEYCWASIHSRAG	CPEB3	661	Q8NE35
WGIGYSFRCDIVDYS	ELOVL7	91	A1L3X0
DSDWTGYYCNCTTRT	ITGB3	576	P05106
AVYRCSASTRLWYEC	KLHDC7A	691	Q5VTJ3
AWTYTFYDNCCRLRC	CYP4F3	36	Q08477
GEDFTCFWAGCVRRY	GLIS1	226	Q8NBF1
AYYLACGFCRWTSRD	DCTN4	106	Q9UJW0
GFASWIEYLCVDHCF	NPEPPS	376	P55786
ASCWHEDSLFRFCYY	CYP8B1	161	Q9UNU6
FPRALEECFFAYCWA	LIPE	691	Q05469
WRSSTVCSLDCEYYN	OTOGL	1196	Q3ZCN5
CFYREDEWCAGFGLY	NYNRIN	1316	Q9P2P1
FYVKGFYCAECRAGW	PAMR1	106	Q6UXH9
FYCAECRAGWYGGDC	PAMR1	111	Q6UXH9
YKCICSDGWEGAYCE	JAG1	651	P78504
DTYSLYCYPCTWGDC	GAREM2	546	Q75VX8
DSCTYYFSWDSRAAC	IGF2R	2111	P11717
LEYVSSLDFWYCKRC	RBM6	531	P78332
RCTFCVDAGVWYYEV	RSPRY1	351	Q96DX4
EYSCAYDGCRQLIWY	RSPRY1	396	Q96DX4
DILEDYCMWRGYEYC	SMARCA1	516	P28370
VRTVESCWYFGRSFC	TAAR6	91	Q96RI8
VRSVESCWYFGDSYC	TAAR9	91	Q96RI9
EIYRFGTQYWFLGCC	SLC5A6	91	Q9Y289
TRFWFPCVDSYSELC	TAF2	186	Q6P1X5
CGNYTTFWGACFAYI	SLC46A3	141	Q7Z3Q1
CHLWYAVLCGYVSEF	RMDN2	261	Q96LZ7
RDPYCAWDGSACSRY	SEMA3A	531	Q14563
TSYYWCKFCSFSCES	TRPS1	431	Q9UHF7
FLYSFSWDFECSQCG	USPL1	351	Q5W0Q7
EGYACDTDLRGWYRF	UMOD	191	P07911
WIYCVGEDFVLYCFS	SMU1	456	Q2TAY7
YCEPAFWCSISYYEL	SMAD3	226	P84022
YDSYAMYLCEWCRTR	TLCD3A	86	Q8TBR7
YALNWLGSLFACYCS	TBC1D23	196	Q9NUY8
ECTTYWYIFVFCSAL	TMEM107	106	Q6UX40
CLECGYEGWRIDTYL	USP47	311	Q96K76
VSECSYCGARWDQYK	TSTD2	416	Q5T7W7
YKGVYEGWYCASDEC	MARS2	161	Q96GW9
YFCRYCAWRVFSDTA	NEURL3	221	Q96EH8
CVYCSYGSWDLFREA	ZDHHC16	211	Q969W1
RCCGVSNYTDWFEVY	TSPAN4	146	O14817
AACYVCWAFARAYEP	TBCD	466	Q9BTW9
AYCKNSVDGLWYCFD	USP31	726	Q70CQ4
WCRGYFRDYCNIIAF	TMIGD3	106	P0DMS9
YDCAECGKSFSYWSS	ZNF184	446	Q99676