Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	CFTR SLC26A5 SLC4A4 SLC4A5	4.36e-06	32	69	4	GO:0015106
GeneOntologyMolecularFunction	potassium channel inhibitor activity	WNK1 WNK3 WNK2	6.39e-06	11	69	3	GO:0019870
GeneOntologyMolecularFunction	ion channel inhibitor activity	CFTR WNK1 WNK3 WNK2	2.27e-05	48	69	4	GO:0008200
GeneOntologyMolecularFunction	channel inhibitor activity	CFTR WNK1 WNK3 WNK2	2.67e-05	50	69	4	GO:0016248
GeneOntologyMolecularFunction	transporter inhibitor activity	CFTR WNK1 WNK3 WNK2	2.89e-05	51	69	4	GO:0141110
GeneOntologyMolecularFunction	potassium channel regulator activity	KCNE1 WNK1 WNK3 WNK2	4.49e-05	57	69	4	GO:0015459
GeneOntologyMolecularFunction	AMPA glutamate receptor activity	GRIA3 GRIA4	7.03e-05	4	69	2	GO:0004971
GeneOntologyMolecularFunction	sodium:bicarbonate symporter activity	SLC4A4 SLC4A5	1.75e-04	6	69	2	GO:0008510
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC26A5 SLC4A4 SLC4A5	1.82e-04	32	69	3	GO:0005452
GeneOntologyMolecularFunction	ion channel regulator activity	KCNE1 CFTR WNK1 WNK3 WNK2	2.44e-04	162	69	5	GO:0099106
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CACNA1B KCNE1 CFTR SLC26A5 TMEM63C GRIA3 GRIA4 SLC4A4 SLC9C2 SLC4A5	2.62e-04	758	69	10	GO:0015318
GeneOntologyMolecularFunction	channel regulator activity	KCNE1 CFTR WNK1 WNK3 WNK2	3.40e-04	174	69	5	GO:0016247
GeneOntologyMolecularFunction	transporter regulator activity	KCNE1 CFTR WNK1 WNK3 WNK2	3.67e-04	177	69	5	GO:0141108
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA1B KCNE1 CFTR SLC26A5 TMEM63C GRIA3 GRIA4 SLC4A4 SLC9C2 SLC4A5	3.76e-04	793	69	10	GO:0015075
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	CFTR SLC26A5 GRIA3 GRIA4 SLC4A4 SLC4A5	5.24e-04	293	69	6	GO:0008514
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNA1B KCNE1 CFTR SLC26A5 TMEM63C GRIA3 GRIA4 GJA10 SLC4A4 SLC9C2 SLC14A2 SLC4A5	6.60e-04	1180	69	12	GO:0022857
GeneOntologyMolecularFunction	monoatomic cation:bicarbonate symporter activity	SLC4A4 SLC4A5	8.96e-04	13	69	2	GO:0140410
GeneOntologyMolecularFunction	gated channel activity	CACNA1B KCNE1 CFTR TMEM63C GRIA3 GRIA4	1.04e-03	334	69	6	GO:0022836
GeneOntologyMolecularFunction	antiporter activity	SLC26A5 SLC4A4 SLC9C2 SLC4A5	1.33e-03	138	69	4	GO:0015297
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CACNA1B KCNE1 TMEM63C GRIA3 GRIA4 SLC4A4 SLC9C2 SLC4A5	1.40e-03	627	69	8	GO:0022890
GeneOntologyMolecularFunction	transporter activity	CACNA1B KCNE1 CFTR SLC26A5 TMEM63C GRIA3 GRIA4 GJA10 SLC4A4 SLC9C2 SLC14A2 SLC4A5	1.42e-03	1289	69	12	GO:0005215
GeneOntologyMolecularFunction	glutamate-gated receptor activity	GRIA3 GRIA4	1.55e-03	17	69	2	GO:0004970
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	CFTR SLC26A5 SLC4A4 SLC4A5	1.86e-03	151	69	4	GO:0008509
GeneOntologyMolecularFunction	channel activity	CACNA1B KCNE1 CFTR TMEM63C GRIA3 GRIA4 GJA10	2.20e-03	525	69	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1B KCNE1 CFTR TMEM63C GRIA3 GRIA4 GJA10	2.23e-03	526	69	7	GO:0022803
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	CFTR SLC26A5 SLC4A4 SLC4A5	2.91e-03	171	69	4	GO:0015103
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GRIA3 GRIA4	3.09e-03	24	69	2	GO:0099507
GeneOntologyMolecularFunction	glutamate receptor activity	GRIA3 GRIA4	3.91e-03	27	69	2	GO:0008066
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	CFTR TMEM63C GRIA3 GRIA4	4.48e-03	193	69	4	GO:0015276
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	PDE6A PLCXD3 PLCG1	4.62e-03	97	69	3	GO:0008081
GeneOntologyMolecularFunction	ligand-gated channel activity	CFTR TMEM63C GRIA3 GRIA4	4.82e-03	197	69	4	GO:0022834
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1B KCNE1 CFTR TMEM63C GRIA3 GRIA4	5.05e-03	459	69	6	GO:0005216
GeneOntologyMolecularFunction	amyloid-beta binding	CACNA1B GRIA3 GRIA4	5.31e-03	102	69	3	GO:0001540
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1B KCNE1 GRIA3 SLC4A4 SLC9C2 SLC4A5	5.37e-03	465	69	6	GO:0046873
GeneOntologyBiologicalProcess	positive regulation of potassium ion import across plasma membrane	WNK1 WNK3 WNK2	1.24e-06	7	69	3	GO:1903288
GeneOntologyBiologicalProcess	regulation of potassium ion import	WNK1 WNK3 WNK2	2.97e-06	9	69	3	GO:1903286
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	CFTR SLC4A4 WNK1 SLC9C2 SLC4A5 WNK3 WNK2	6.09e-06	208	69	7	GO:0035725
GeneOntologyBiologicalProcess	bicarbonate transport	CFTR SLC26A5 SLC4A4 SLC4A5	7.77e-06	38	69	4	GO:0015701
GeneOntologyBiologicalProcess	positive regulation of potassium ion transmembrane transport	KCNE1 WNK1 WNK3 WNK2	1.17e-05	42	69	4	GO:1901381
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	CACNA1B KCNE1 CFTR SLC26A5 TMEM63C GRIA3 GRIA4 PLCG1 SLC4A4 WNK1 SLC9C2 SLC4A5 WNK3 WNK2	1.59e-05	1115	69	14	GO:0034220
GeneOntologyBiologicalProcess	positive regulation of potassium ion transport	KCNE1 WNK1 WNK3 WNK2	3.20e-05	54	69	4	GO:0043268
GeneOntologyBiologicalProcess	sodium ion transport	CFTR SLC4A4 WNK1 SLC9C2 SLC4A5 WNK3 WNK2	3.70e-05	275	69	7	GO:0006814
GeneOntologyBiologicalProcess	positive regulation of monoatomic ion transmembrane transport	KCNE1 CFTR PLCG1 WNK1 WNK3 WNK2	4.43e-05	192	69	6	GO:0034767
GeneOntologyBiologicalProcess	negative regulation of sodium ion transport	WNK1 WNK3 WNK2	5.27e-05	22	69	3	GO:0010766
GeneOntologyBiologicalProcess	negative regulation of pancreatic juice secretion	WNK1 WNK3	1.10e-04	5	69	2	GO:0090188
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	CACNA1B WNK1 SLC9C2 WNK3 WNK2	1.14e-04	142	69	5	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	CACNA1B WNK1 SLC9C2 WNK3 WNK2	1.14e-04	142	69	5	GO:0098659
GeneOntologyBiologicalProcess	monoatomic ion transport	CACNA1B KCNE1 CFTR SLC26A5 TMEM63C GRIA3 GRIA4 PLCG1 SLC4A4 WNK1 SLC9C2 SLC4A5 WNK3 WNK2	1.54e-04	1374	69	14	GO:0006811
GeneOntologyBiologicalProcess	positive regulation of monoatomic ion transport	KCNE1 CFTR PLCG1 WNK1 WNK3 WNK2	2.64e-04	266	69	6	GO:0043270
GeneOntologyBiologicalProcess	negative regulation of monoatomic ion transport	KCNE1 SLC26A5 WNK1 WNK3 WNK2	2.70e-04	171	69	5	GO:0043271
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	CACNA1B KCNE1 CFTR TMEM63C PLCG1 SLC4A4 WNK1 SLC9C2 SLC4A5 WNK3 WNK2	2.73e-04	942	69	11	GO:0098655
GeneOntologyBiologicalProcess	regulation of intracellular pH	CFTR SLC4A4 SLC9C2 SLC4A5	2.79e-04	94	69	4	GO:0051453
GeneOntologyBiologicalProcess	positive regulation of cation transmembrane transport	KCNE1 PLCG1 WNK1 WNK3 WNK2	2.93e-04	174	69	5	GO:1904064
GeneOntologyBiologicalProcess	positive regulation of transmembrane transport	KCNE1 CFTR PLCG1 WNK1 WNK3 WNK2	3.03e-04	273	69	6	GO:0034764
GeneOntologyBiologicalProcess	regulation of potassium ion transmembrane transport	KCNE1 WNK1 WNK3 WNK2	3.14e-04	97	69	4	GO:1901379
GeneOntologyBiologicalProcess	negative regulation of protein localization to membrane	KCNE1 WNK1 WNK3	3.49e-04	41	69	3	GO:1905476
GeneOntologyBiologicalProcess	regulation of cellular pH	CFTR SLC4A4 SLC9C2 SLC4A5	3.67e-04	101	69	4	GO:0030641
GeneOntologyBiologicalProcess	regulation of pancreatic juice secretion	WNK1 WNK3	3.91e-04	9	69	2	GO:0090186
GeneOntologyBiologicalProcess	regulation of monoatomic ion transmembrane transport	KCNE1 CFTR SLC26A5 PLCG1 WNK1 WNK3 WNK2	4.82e-04	417	69	7	GO:0034765
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	CACNA1B KCNE1 CFTR SLC26A5 PLCG1 SLC4A4 WNK1 SLC9C2 SLC4A5 WNK3 WNK2	5.23e-04	1017	69	11	GO:0098660
GeneOntologyBiologicalProcess	potassium ion import across plasma membrane	WNK1 WNK3 WNK2	6.65e-04	51	69	3	GO:1990573
GeneOntologyBiologicalProcess	regulation of monoatomic ion transport	CACNA1B KCNE1 CFTR SLC26A5 PLCG1 WNK1 WNK3 WNK2	6.66e-04	577	69	8	GO:0043269
GeneOntologyBiologicalProcess	regulation of pH	CFTR SLC4A4 SLC9C2 SLC4A5	7.04e-04	120	69	4	GO:0006885
GeneOntologyBiologicalProcess	sensory organ development	FAT4 FLT1 PDE6A SLC26A5 SRF CXCL14 RP1 SLC4A5 ZEB2	7.04e-04	730	69	9	GO:0007423
GeneOntologyBiologicalProcess	regulation of potassium ion transport	KCNE1 WNK1 WNK3 WNK2	7.26e-04	121	69	4	GO:0043266
Domain	Kinase_OSR1/WNK_CCT	WNK1 WNK3 WNK2	1.00e-06	6	70	3	IPR024678
Domain	OSR1_C	WNK1 WNK3 WNK2	1.00e-06	6	70	3	PF12202
Domain	Na/HCO3_transpt	SLC4A4 SLC4A5	1.37e-04	5	70	2	IPR003024
Domain	Band3_cytoplasmic_dom	SLC4A4 SLC4A5	4.90e-04	9	70	2	IPR013769
Domain	Band_3_cyto	SLC4A4 SLC4A5	4.90e-04	9	70	2	PF07565
Domain	-	SLC4A4 SLC4A5	4.90e-04	9	70	2	3.40.1100.10
Domain	HCO3_cotransp	SLC4A4 SLC4A5	6.11e-04	10	70	2	PF00955
Domain	HCO3_transpt_C	SLC4A4 SLC4A5	6.11e-04	10	70	2	IPR011531
Domain	PTrfase/Anion_transptr	SLC4A4 SLC4A5	6.11e-04	10	70	2	IPR016152
Domain	HCO3_transpt_euk	SLC4A4 SLC4A5	6.11e-04	10	70	2	IPR003020
Domain	RWD	DHX57 RWDD2B	7.45e-04	11	70	2	PF05773
Domain	RWD-domain	DHX57 RWDD2B	8.92e-04	12	70	2	IPR006575
Domain	-	AP1B1 MROH2B CTNNBL1 RIPOR3 NCAPG2	1.47e-03	222	70	5	1.25.10.10
Domain	Laminin_N	NTN4 LAMA3	1.61e-03	16	70	2	IPR008211
Domain	LAMININ_NTER	NTN4 LAMA3	1.61e-03	16	70	2	PS51117
Domain	Laminin_N	NTN4 LAMA3	1.61e-03	16	70	2	PF00055
Domain	LamNT	NTN4 LAMA3	1.61e-03	16	70	2	SM00136
Domain	Iontro_rcpt	GRIA3 GRIA4	2.04e-03	18	70	2	IPR001320
Domain	Lig_chan-Glu_bd	GRIA3 GRIA4	2.04e-03	18	70	2	PF10613
Domain	Iono_rcpt_met	GRIA3 GRIA4	2.04e-03	18	70	2	IPR001508
Domain	Glu/Gly-bd	GRIA3 GRIA4	2.04e-03	18	70	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIA3 GRIA4	2.04e-03	18	70	2	SM00918
Domain	Lig_chan	GRIA3 GRIA4	2.04e-03	18	70	2	PF00060
Domain	PI-PLC-X	PLCXD3 PLCG1	2.04e-03	18	70	2	PF00388
Domain	PBPe	GRIA3 GRIA4	2.04e-03	18	70	2	SM00079
Domain	PLCXc	PLCXD3 PLCG1	2.04e-03	18	70	2	SM00148
Domain	PIPLC_X_DOMAIN	PLCXD3 PLCG1	2.27e-03	19	70	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCXD3 PLCG1	2.27e-03	19	70	2	IPR000909
Domain	IGv	FLT1 OBSCN NCAM2	2.81e-03	75	70	3	SM00406
Domain	ARM-like	AP1B1 MROH2B CTNNBL1 RIPOR3 NCAPG2	3.43e-03	270	70	5	IPR011989
Domain	-	PLCXD3 PLCG1	3.93e-03	25	70	2	3.20.20.190
Domain	PLC-like_Pdiesterase_TIM-brl	PLCXD3 PLCG1	3.93e-03	25	70	2	IPR017946
Domain	EGF_LAM_2	NTN4 LAMA3	5.63e-03	30	70	2	PS50027
Domain	EGF_LAM_1	NTN4 LAMA3	5.63e-03	30	70	2	PS01248
Domain	Laminin_EGF	NTN4 LAMA3	7.61e-03	35	70	2	PF00053
Domain	EGF_Lam	NTN4 LAMA3	7.61e-03	35	70	2	SM00180
Domain	ANF_lig-bd_rcpt	GRIA3 GRIA4	8.47e-03	37	70	2	IPR001828
Domain	ANF_receptor	GRIA3 GRIA4	8.47e-03	37	70	2	PF01094
Pubmed	IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.	CFTR SLC4A4 WNK1 WNK3	1.05e-09	8	70	4	21317537
Pubmed	Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed.	WNK1 WNK3 WNK2	3.12e-08	4	70	3	34384519
Pubmed	WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.	WNK1 WNK3 WNK2	3.12e-08	4	70	3	11571656
Pubmed	Human hypertension caused by mutations in WNK kinases.	WNK1 WNK3 WNK2	3.12e-08	4	70	3	11498583
Pubmed	Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.	WNK1 WNK3 WNK2	2.72e-07	7	70	3	20525693
Pubmed	KLHL2 interacts with and ubiquitinates WNK kinases.	WNK1 WNK3 WNK2	4.34e-07	8	70	3	23838290
Pubmed	The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.	WNK1 WNK3 WNK2	4.34e-07	8	70	3	23387299
Pubmed	Mouse model resources for vision research.	DPAGT1 PDE6A RP1 SLC4A5	1.44e-06	41	70	4	21052544
Pubmed	The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma.	FLT1 PLCG1	3.99e-06	2	70	2	9299537
Pubmed	Kinetic properties of human AMPA-type glutamate receptors expressed in HEK293 cells.	GRIA3 GRIA4	3.99e-06	2	70	2	12670305
Pubmed	Control of kinetic properties of AMPA receptor channels by nuclear RNA editing.	GRIA3 GRIA4	3.99e-06	2	70	2	7992055
Pubmed	Elimination of redundant synaptic inputs in the absence of synaptic strengthening.	GRIA3 GRIA4	3.99e-06	2	70	2	22090494
Pubmed	Cell-specific cre recombinase expression allows selective ablation of glutamate receptors from mouse horizontal cells.	GRIA4 GJA10	3.99e-06	2	70	2	24349437
Pubmed	Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE.	PLCG1 AGAP2	3.99e-06	2	70	2	11823862
Pubmed	Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4.	GRIA3 GRIA4	3.99e-06	2	70	2	18316356
Pubmed	Regulation of Na+-K+-Cl- cotransporter type 2 by the with no lysine kinase-dependent signaling pathway.	WNK1 WNK3	3.99e-06	2	70	2	30917032
Pubmed	Interaction between CFTR and prestin (SLC26A5).	CFTR SLC26A5	3.99e-06	2	70	2	20138822
Pubmed	Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers.	FLT1 PLCG1	3.99e-06	2	70	2	11312102
Pubmed	GluA4 is indispensable for driving fast neurotransmission across a high-fidelity central synapse.	GRIA3 GRIA4	3.99e-06	2	70	2	21690196
Pubmed	WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.	WNK1 WNK2	3.99e-06	2	70	2	35849656
Pubmed	The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells.	GRIA3 GRIA4	1.20e-05	3	70	2	28397107
Pubmed	NBCe1 (SLC4A4) a potential pH regulator in enamel organ cells during enamel development in the mouse.	CFTR SLC4A4	1.20e-05	3	70	2	25012520
Pubmed	Study on GRIA2, GRIA3 and GRIA4 genes highlights a positive association between schizophrenia and GRIA3 in female patients.	GRIA3 GRIA4	1.20e-05	3	70	2	18163426
Pubmed	Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells.	GRIA3 GRIA4	1.20e-05	3	70	2	12172541
Pubmed	Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells.	GRIA4 GJA10	1.20e-05	3	70	2	29352045
Pubmed	Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling.	WNK1 WNK2	1.20e-05	3	70	2	23797875
Pubmed	Synaptic AMPA receptor plasticity and behavior.	GRIA3 GRIA4	1.20e-05	3	70	2	19217372
Pubmed	WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway.	WNK3 WNK2	1.20e-05	3	70	2	18768590
Pubmed	MicroRNA 224 Regulates Ion Transporter Expression in Ameloblasts To Coordinate Enamel Mineralization.	CFTR SLC4A4	1.20e-05	3	70	2	26055330
Pubmed	The Importance of Connexin 43 in Enamel Development and Mineralization.	CFTR SLC4A4	1.20e-05	3	70	2	30013481
Pubmed	Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.	CACNA1B GRIA3 GRIA4	1.53e-05	24	70	3	22534482
Pubmed	A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing.	GRIA3 GRIA4	2.39e-05	4	70	2	10688364
Pubmed	IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct.	CFTR SLC4A4	2.39e-05	4	70	2	19033647
Pubmed	Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival.	GRIA3 GRIA4	2.39e-05	4	70	2	28608780
Pubmed	AMPA receptor subunits expressed by single astrocytes in the juvenile mouse hippocampus.	GRIA3 GRIA4	2.39e-05	4	70	2	9221927
Pubmed	Interaction proteomics reveals brain region-specific AMPA receptor complexes.	GRIA3 GRIA4	2.39e-05	4	70	2	25337787
Pubmed	Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors.	GRIA3 GRIA4	2.39e-05	4	70	2	17828255
Pubmed	Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-γ1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma.	PLCG1 AGAP2	2.39e-05	4	70	2	26464646
Pubmed	The N-terminal domain modulates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor desensitization.	GRIA3 GRIA4	2.39e-05	4	70	2	24652293
Pubmed	Electrophysiological properties of AMPA receptors are differentially modulated depending on the associated member of the TARP family.	GRIA3 GRIA4	2.39e-05	4	70	2	17409242
Pubmed	Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.	FLT1 PLCG1	2.39e-05	4	70	2	9600074
Pubmed	Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites.	FLT1 PLCG1	2.39e-05	4	70	2	9398617
Pubmed	Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein.	FLT1 PLCG1	2.39e-05	4	70	2	17962812
Pubmed	Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit.	GRIA3 GRIA4	2.39e-05	4	70	2	14561864
Pubmed	Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.	GRIA3 GRIA4	2.39e-05	4	70	2	10027300
Pubmed	Chromosomal localization of human glutamate receptor genes.	GRIA3 GRIA4	2.39e-05	4	70	2	1319477
Pubmed	AMPA receptors regulate dynamic equilibrium of presynaptic terminals in mature hippocampal networks.	GRIA3 GRIA4	2.39e-05	4	70	2	12692557
Pubmed	Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis.	GRIA3 GRIA4	2.39e-05	4	70	2	12125045
Pubmed	Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.	GRIA3 GRIA4	2.39e-05	4	70	2	25433904
Pubmed	SLC26A9 is a Cl(-) channel regulated by the WNK kinases.	WNK1 WNK3	2.39e-05	4	70	2	17673510
Pubmed	AMPA receptor-mediated excitotoxicity in human NT2-N neurons results from loss of intracellular Ca2+ homeostasis following marked elevation of intracellular Na+.	GRIA3 GRIA4	2.39e-05	4	70	2	9648857
Pubmed	NMDA Receptors Regulate the Development of Neuronal Intrinsic Excitability through Cell-Autonomous Mechanisms.	GRIA3 GRIA4	3.98e-05	5	70	2	29163060
Pubmed	RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.	GRIA3 GRIA4	3.98e-05	5	70	2	1717158
Pubmed	Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.	WNK1 WNK3	3.98e-05	5	70	2	24641320
Pubmed	Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites.	GRIA3 GRIA4	3.98e-05	5	70	2	16129400
Pubmed	Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM.	GRIA3 GRIA4	3.98e-05	5	70	2	9482932
Pubmed	WNK kinases sense molecular crowding and rescue cell volume via phase separation.	WNK1 WNK3	3.98e-05	5	70	2	36318922
Pubmed	Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF.	GRIA3 GRIA4	3.98e-05	5	70	2	15797551
Pubmed	WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters.	WNK1 WNK2	5.96e-05	6	70	2	21733846
Pubmed	Glutamate receptor δ2 is essential for input pathway-dependent regulation of synaptic AMPAR contents in cerebellar Purkinje cells.	GRIA3 GRIA4	8.33e-05	7	70	2	21368048
Pubmed	Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.	GRIA3 GRIA4	8.33e-05	7	70	2	33981040
Pubmed	Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer.	GRIA3 GRIA4	8.33e-05	7	70	2	10407040
Pubmed	Glutamate receptors in cortical plasticity: molecular and cellular biology.	GRIA3 GRIA4	8.33e-05	7	70	2	9016303
Pubmed	Glutamate receptors: brain function and signal transduction.	GRIA3 GRIA4	8.33e-05	7	70	2	9651535
Pubmed	TARP γ-2 and γ-8 Differentially Control AMPAR Density Across Schaffer Collateral/Commissural Synapses in the Hippocampal CA1 Area.	GRIA3 GRIA4	8.33e-05	7	70	2	27076426
Pubmed	Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.	GRIA3 GRIA4	1.11e-04	8	70	2	21172611
Pubmed	Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea.	GRIA3 GRIA4	1.11e-04	8	70	2	23217150
Pubmed	UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.	SRF UTY	1.42e-04	9	70	2	23028370
Pubmed	Changes of several brain receptor complexes in the cerebral cortex of patients with Alzheimer disease: probable new potential pharmaceutical targets.	GRIA3 GRIA4	1.42e-04	9	70	2	24292102
Pubmed	Expression of glutamate receptor subunit genes during development of the mouse retina.	GRIA3 GRIA4	1.42e-04	9	70	2	9051806
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	STXBP5L TGFBRAP1 OBSCN SRF TMEM63C LAMA3 NCAM2 PLCG1 POLK SLC4A5 WNK2	1.81e-04	1489	70	11	28611215
Pubmed	CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human β₂-adrenergic receptor.	KCNE1 GRIA3 WNK1	2.01e-04	56	70	3	24561123
Pubmed	90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling.	PLCG1 SLA	2.17e-04	11	70	2	15117958
Pubmed	Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.	WNK1 WNK3	2.60e-04	12	70	2	27782176
Pubmed	The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.	GRIA3 GRIA4	2.60e-04	12	70	2	11891216
Pubmed	UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.	SRF UTY	3.07e-04	13	70	2	22192413
Pubmed	Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.	GRIA3 GRIA4	3.07e-04	13	70	2	20859245
Pubmed	Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice.	GRIA3 GRIA4	3.07e-04	13	70	2	25218043
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	DIS3L2 AP1B1 DHX57 WNK1 WNK3 WNK2	3.40e-04	462	70	6	31138677
Pubmed	β3GnT2 maintains adenylyl cyclase-3 signaling and axon guidance molecule expression in the olfactory epithelium.	PLXNA4 NCAM2	3.58e-04	14	70	2	21525298
Pubmed	Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.	NTN4 NCAM2	3.58e-04	14	70	2	20029409
Pubmed	Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.	GRIA3 GRIA4	4.12e-04	15	70	2	9481670
Pubmed	Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development.	PDE6A RBP3	4.12e-04	15	70	2	11468275
Pubmed	PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.	GRIA3 GRIA4	4.71e-04	16	70	2	16055064
Pubmed	TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties.	FLT1 ZEB2	4.71e-04	16	70	2	36418889
Pubmed	The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.	CFTR SLC4A4	5.33e-04	17	70	2	16472605
Pubmed	Nonsyndromic Retinitis Pigmentosa Overview	PDE6A RBP3 RP1	5.95e-04	81	70	3	20301590
Pubmed	Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation.	GRIA3 GRIA4	5.98e-04	18	70	2	18311135
Pubmed	Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice.	FLT1 WNK1	5.98e-04	18	70	2	19644017
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	AP1B1 GRIA3 GRIA4 SLC4A4 ZEB2 WNK3 WNK2 AGAP2	6.95e-04	963	70	8	28671696
Pubmed	Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.	AP1B1 NCAM2	7.41e-04	20	70	2	16009131
Pubmed	Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.	GRIA3 GRIA4	9.83e-04	23	70	2	8464923
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	AP1B1 RAD54L2 POLK NCAPG2	1.07e-03	222	70	4	37071664
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIA3 GRIA4	1.07e-03	24	70	2	35746896
Pubmed	Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice†.	CFTR SLC4A4	1.07e-03	24	70	2	37471646
Pubmed	High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.	GRIA3 GRIA4	1.07e-03	24	70	2	22632720
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	OBSCN PLXNA4 WNK3	1.13e-03	101	70	3	10997877
Pubmed	Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.	DPYD ZEB2	1.26e-03	26	70	2	26212757
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	PDE6A RBP3 RP1 GJA10	1.27e-03	233	70	4	32290105
Pubmed	Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.	AP1B1 SLC4A4 AGAP2	1.44e-03	110	70	3	27889896
Cytoband	4q28.1	FAT4 ANKRD50	2.71e-04	16	70	2	4q28.1
Cytoband	5p13.1	MROH2B PLCXD3	3.45e-04	18	70	2	5p13.1
Cytoband	1q42.13	OBSCN URB2	2.57e-03	49	70	2	1q42.13
GeneFamily	Glutamate ionotropic receptor AMPA type subunits	GRIA3 GRIA4	4.13e-05	4	48	2	1200
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 STXBP5L CFTR OBSCN NCAM2 SLC4A4	4.55e-07	184	70	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 STXBP5L CFTR OBSCN NCAM2 SLC4A4	4.55e-07	184	70	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 STXBP5L CFTR OBSCN NCAM2 SLC4A4	4.55e-07	184	70	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	NTN4 CFTR RP1 SLC4A4 SLC4A5 WNK2	4.70e-07	185	70	6	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NTN4 MROH2B LAMA3 CXCL14 PLCXD3 ANKRD50	4.85e-07	186	70	6	fef543f188edb0d1704d9c6ace366a0f8017bf53
ToppCell	renal_papilla_nuclei-Adult_normal_reference\|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	PLXNA4 RIPOR3 PLCXD3 SLC14A2 UTY ZEB2	5.84e-07	192	70	6	6c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	CACNA1B OBSCN CXCL14 SLC4A4 AGAP2 FBXW7	7.41e-07	200	70	6	5c7263c862093ad9dbc81d06b16b6f74e8a6b634
ToppCell	Substantia_nigra-Macroglia-CSF_related\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	C10orf67 AKAP14 ACSBG2 RP1 SLC14A2	2.42e-06	136	70	5	47663c5d81c766a333207a44fc5b58b07309ee76
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	C10orf67 AKAP14 ACSBG2 RP1 SLC14A2	2.42e-06	136	70	5	6d2e5b871f4cf8d64e6fe0be666fb3490797c635
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	C10orf67 AKAP14 ACSBG2 RP1 SLC14A2	2.42e-06	136	70	5	fd4269d194c7c11c6ab4383393a01efab05cbace
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	C10orf67 AKAP14 ACSBG2 RP1 SLC14A2	2.42e-06	136	70	5	3f6cec8d52c84191f7f6e2dd4dc47524dfd5b21b
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	C10orf67 AKAP14 ACSBG2 RP1 SLC14A2	2.42e-06	136	70	5	67d736096d6b6ddb4722809557f5e987063b8d23
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLXNA4 RIPOR3 PLCXD3 S1PR3 ZEB2	7.00e-06	169	70	5	a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCell	Mesenchymal_cells-Osteo-CAR\|Mesenchymal_cells / Lineage and Cell class	FAT4 CXCL14 PLPPR5 RGS3 ZEB2	8.07e-06	174	70	5	430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIS3L2 NCAM2 GRIA4 WNK2 FBXW7	1.00e-05	182	70	5	c00e503f442d44fbae73c5e2dc85be69e294e67a
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 FLT1 LAMA3 CXCL14 S1PR3	1.14e-05	187	70	5	eb011a3d8a3025cebb0fba36d403be906305372c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 RIPOR3 PLCXD3 S1PR3 ZEB2	1.20e-05	189	70	5	c734e5693808a0333139e87bd5be2597a9252afe
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PLXNA4 CXCL14 RIPOR3 ERMP1 RP1	1.23e-05	190	70	5	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 RIPOR3 PLCXD3 S1PR3 ZEB2	1.23e-05	190	70	5	2e592323085ba9c019d678ac2a784462ab470ed9
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 RIPOR3 PLCXD3 S1PR3 ZEB2	1.23e-05	190	70	5	445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 RIPOR3 PLCXD3 S1PR3 ZEB2	1.27e-05	191	70	5	c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 RIPOR3 PLCXD3 S1PR3 ZEB2	1.27e-05	191	70	5	cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FAT4 PLXNA4 CXCL14 GRIA3 SLC4A4	1.30e-05	192	70	5	72881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PLXNA4 CXCL14 GRIA4 MCM5 NCAPG2	1.33e-05	193	70	5	bbdfda6665941cfa1965418bb91ef9ff43b1326f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 RIPOR3 PLCXD3 S1PR3 ZEB2	1.43e-05	196	70	5	a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 RIPOR3 PLCXD3 S1PR3 ZEB2	1.43e-05	196	70	5	3e6803587d8566fd08cb8b290be3b6461743d79c
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal-CPNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	PLXNA4 GRIA4 PLPPR5 SLA ZEB2	1.51e-05	198	70	5	60d8d3bbd754ffde41c50013d822667b185a9751
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	NTN4 PLXNA4 ANKRD50 SLA ZEB2	1.54e-05	199	70	5	a255484ba77bd2741a541da278efc8cf4abbe570
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	CACNA1B OBSCN CXCL14 SLC4A4 AGAP2	1.58e-05	200	70	5	61d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KCNE1 C10orf67 AKAP14 RP1 SLC9C2	1.58e-05	200	70	5	af6a551f83808c1c839df7ba7b1702ca28ea6e1b
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	FAT4 PLXNA4 GRIA3 SLC4A4 ZEB2	1.58e-05	200	70	5	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KCNE1 C10orf67 AKAP14 RP1 SLC9C2	1.58e-05	200	70	5	73ac1cf40ddd764be1100cbfaaa29563665457d8
ToppCell	Control-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DPAGT1 LAMA3 GRIA4 WNK2	4.81e-05	127	70	4	556aaf88719c83f307fa50dfac151136ed05c8ad
ToppCell	Bronchial_Brush-Epithelial-Ciliated_2\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	STXBP5L PLXNA4 NCAM2 SLC4A5	5.59e-05	132	70	4	780a391924f776dc6fbe44ddcf4ae0583a1e2157
ToppCell	Bronchial_Brush-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	STXBP5L PLXNA4 NCAM2 SLC4A5	6.10e-05	135	70	4	366a417f9ef7c0d86e9f262d97bf788f478315ee
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CXCL14 ERMP1 RP1 OR8J1	6.64e-05	138	70	4	a88c3ae56b0af60f6e87cabade4f21e2bbb336f2
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B C10orf67 SLC26A5 WNK2	8.04e-05	145	70	4	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CACNA1B PLXNA4 CXCL14 SLC4A4	1.09e-04	157	70	4	b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCell	facs-Heart-RV-24m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCL14 AKAP14 S1PR3 MS4A10	1.12e-04	158	70	4	2ef43d14ee65d004dc62c12ff209bbe12e4db681
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1B FLT1 KCNE1 RP1	1.12e-04	158	70	4	78b48b110b777bcc4c07cd23388bee911c0231d6
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PINX1 CXCL14 RAD54L2 SLC4A4	1.21e-04	161	70	4	9f02b94e29e60d50e92eaa748ebf0c36d3671bb3
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_3\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FAT4 CXCL14 URB2 SLC4A4	1.29e-04	164	70	4	583dda853cee9491dbdcb228c23d8deadc20eb08
ToppCell	facs-Kidney-nan-24m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCL14 PLCXD3 ASB15 SLC14A2	1.32e-04	165	70	4	4cdd80580d5638fd649280ba3893251c2f898f3f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	TMEM63C NCAM2 SLA AGAP2	1.32e-04	165	70	4	9795ce31689bc63f5a2d68725ef00b23a90c3846
ToppCell	facs-Kidney-nan-24m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCL14 PLCXD3 ASB15 SLC14A2	1.32e-04	165	70	4	c746bb22ef52d7f7fa6ee9c37ae6bbe0ccce718e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_CCDC184\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT1 LAMA3 CXCL14 S1PR3	1.39e-04	167	70	4	ef3ef83c213e818597600da15764c5b37763d7b6
ToppCell	15-Distal-Epithelial-Multiciliated_cell\|Distal / Age, Tissue, Lineage and Cell class	KCNE1 C10orf67 AKAP14 RP1	1.45e-04	169	70	4	425d89ab69e9f9eb3df84056676423e390cc6ab1
ToppCell	Control-Mast_cells\|Control / group, cell type (main and fine annotations)	GLOD5 CTNNBL1 ZEB2 WNK3	1.45e-04	169	70	4	fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FAT4 CXCL14 GRIA3 RIPOR3	1.45e-04	169	70	4	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 GRIA4 PLPPR5 S1PR3	1.45e-04	169	70	4	87116c33c5ca8cb1862e103e5607b1df4d264569
ToppCell	Adult-Immune-enucleated_erythrocyte-D122\|Adult / Lineage, Cell type, age group and donor	CCDC106 RWDD2B URB2 NCAPG2	1.45e-04	169	70	4	d5624e5b3687bd3f18f3a2b47a94d11eb1fbdb75
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SRF RIPOR3 PLCXD3 ZEB2	1.49e-04	170	70	4	fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CACNA1B CFTR PLXNA4 CXCL14	1.49e-04	170	70	4	fefb07a7e308b620f946b9ff2b01e1796446fe38
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B STXBP5L TMEM63C PLCXD3	1.49e-04	170	70	4	6a98f47f8c2b5b15e09169bd82eff1e6bf76e5a6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SRF RIPOR3 PLCXD3 ZEB2	1.49e-04	170	70	4	03044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCell	Control-Mast_cells-Mast_cells\|Control / group, cell type (main and fine annotations)	GLOD5 CTNNBL1 ZEB2 WNK3	1.49e-04	170	70	4	c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-NK_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARRDC5 SLA SLC4A5 ZEB2	1.55e-04	172	70	4	f3c16a62eba1ed190318beee131c71c5150b266a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD50 SLA S1PR3 ZEB2	1.66e-04	175	70	4	1b4cefae400bf756d09ece32d3f5c0bd4c6ad73f
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 FLT1 LAMA3 CXCL14	1.66e-04	175	70	4	9d09636a103daa8f622c3dbfd1f1536aaec3b6bb
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_GRIP2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMA3 CXCL14 PLCXD3 ANKRD50	1.66e-04	175	70	4	0c648e7f67ffbe3b476a2ca77d246554f8cd1882
ToppCell	356C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|356C / Donor, Lineage, Cell class and subclass (all cells)	GSTM5 TMEM63C CXCL14 ASB15	1.70e-04	176	70	4	135d51d28a7ad2a67d5a6c49eb6e661f4beb66f5
ToppCell	356C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	GSTM5 TMEM63C CXCL14 ASB15	1.70e-04	176	70	4	2287bd8382f41e36ebb0875a0133bada1ec81fa7
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NTN4 SLC26A5 LAMA3 WNK3	1.73e-04	177	70	4	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	Control-Epithelial_alveolar-AT_1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GSTM5 NTN4 SLC26A5 LAMA3	1.77e-04	178	70	4	aa7d43c655df493f1330a5001efaa484e4a19f69
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLOD5 CFTR ACSBG2 RP1	1.77e-04	178	70	4	58857bb8c13e0e1c6d9f5c1258f00fff62063d68
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 FLT1 LAMA3 CXCL14	1.77e-04	178	70	4	2a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLOD5 CFTR ACSBG2 RP1	1.77e-04	178	70	4	8b7df6ab8709d9ab9dff97677cc4561aec2745bc
ToppCell	Endothelial-A-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	FAT4 FLT1 PLXNA4 PLCXD3	1.77e-04	178	70	4	2f2602b9305d55f25afa9861dd6c6347ae179337
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLOD5 CFTR ACSBG2 RP1	1.77e-04	178	70	4	b0baf5667e3301898b3e45e974b8a8530af6a338
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GSTM5 RIPOR3 PLCXD3 ZEB2	1.77e-04	178	70	4	78a0c6340001a77f5b2d890b6263f574af2e72da
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NTN4 PLCXD3 ACSBG2 SLC4A4	1.85e-04	180	70	4	8f774dcacc1626e4e6492f1eb927b0ed56fbe686
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(INS+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GLOD5 STXBP5L PLPPR5 PLCXD3	1.85e-04	180	70	4	0c5d9245b8a7cc34ad52522d31559906cda55bdf
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NTN4 PLCXD3 ACSBG2 SLC4A4	1.89e-04	181	70	4	bd7e9437839bca543ca5945df43d6525e6a312a8
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NTN4 CFTR LAMA3 SLC4A4	1.89e-04	181	70	4	0513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DPYD KCNE1 SLA ZEB2	1.89e-04	181	70	4	8657d35cd3dff6c89d0fde67d7e7e81e1d6c8884
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FAT4 PLXNA4 CXCL14 SLC4A4	1.89e-04	181	70	4	d7e04e0ca549eac6d9b1192b6578f9b54943d54f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 FLT1 LAMA3 CXCL14	1.89e-04	181	70	4	7846c7b33d1b89364c5a704edaa86520db731c89
ToppCell	Mesenchymal_cells-Adipo-CAR\|Mesenchymal_cells / Lineage and Cell class	CXCL14 RGS3 S1PR3 ZEB2	1.89e-04	181	70	4	1cfb03eb03a37b036b4eeacec69c9b8163af1ee4
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	FAT4 GRIA3 S1PR3 ZEB2	1.93e-04	182	70	4	ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 FLT1 LAMA3 CXCL14	1.93e-04	182	70	4	d3a037268f026eb2f84428b1821022503cef7756
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLT1 LAMA3 SLC4A4 RGS3	1.93e-04	182	70	4	c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLT1 LAMA3 SLC4A4 RGS3	1.93e-04	182	70	4	d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NTN4 CFTR LAMA3 SLC4A4	1.97e-04	183	70	4	6847c1252d6bb105524f812658112517fd351eab
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PLXNA4 CXCL14 ERMP1 RP1	1.97e-04	183	70	4	83592c332b1e82673f993d37c7f480befdc3dcda
ToppCell	droplet-Kidney-nan-21m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTNNBL1 CCDC106 RGS3 ZEB2	1.97e-04	183	70	4	ad7421623e4c0c5ba02eec56e9bdae43ebb88d90
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NTN4 CFTR LAMA3 SLC4A4	2.01e-04	184	70	4	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN PLCXD3 ASB15 WNK2	2.01e-04	184	70	4	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NTN4 CFTR LAMA3 SLC4A5	2.05e-04	185	70	4	0d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NTN4 CFTR LAMA3 SLC4A4	2.05e-04	185	70	4	fefaf227d89f680d6f3e91c4a94e26ab4d0dc6c3
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NTN4 CXCL14 RIPOR3 ERMP1	2.05e-04	185	70	4	6da9a06e1514d5d5f47359a14637f02539846096
ToppCell	Control-Epithelial_alveolar\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GSTM5 NTN4 SLC26A5 LAMA3	2.05e-04	185	70	4	3937e026add96a396122139daf8011cfbc60e75c
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NTN4 CFTR LAMA3 SLC4A4	2.05e-04	185	70	4	929b68b05b7686341329ac756d7df172cb4b810b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 FLT1 LAMA3 CXCL14	2.05e-04	185	70	4	0b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NTN4 LAMA3 CXCL14 ANKRD50	2.05e-04	185	70	4	4c42bd3cd72f91f4d4ebb849069a03761a2cd662
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NTN4 CXCL14 RIPOR3 ERMP1	2.05e-04	185	70	4	4a188e2566a75d1b4f3c879a8c241c277c4b451c
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DPYD NCAM2 S1PR3 ZEB2	2.05e-04	185	70	4	1ac6a32cc56d5d819649bdd99518e2ead0eead4c
ToppCell	Mesenchymal_cells-Osteo-CAR\|World / Lineage and Cell class	FAT4 CXCL14 PLPPR5 RGS3	2.05e-04	185	70	4	16f1588893d09c864e0cb4f837a1b972a1a57baa
ToppCell	LV-07._Pericyte\|LV / Chamber and Cluster_Paper	FLT1 RIPOR3 ZEB2 AGAP2	2.05e-04	185	70	4	acb38eba871ec72f2a8136a33b87d33b8c85465d
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NTN4 PLCXD3 ACSBG2 SLC4A4	2.10e-04	186	70	4	948815663c212c4311329d503b5991cbbbff9808
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	DPYD FAT4 S1PR3 ZEB2	2.10e-04	186	70	4	7def03dd856b765bd3f493288641981c4f7fd26e
Drug	1-EBIO	CACNA1B KCNE1 CFTR SLC4A4	5.01e-06	37	70	4	CID000082320
Drug	AC1L1JYL	FLT1 SRF PINX1 PLPPR5 PLCXD3 PLCG1 SLA RGS3 S1PR3	7.11e-06	434	70	9	CID000005262
Drug	thiazide	CFTR SLC4A4 WNK1 WNK3 WNK2	1.73e-05	104	70	5	CID000002720
Drug	DeltaR	CACNA1B CFTR AGAP2	1.83e-05	17	70	3	CID000028718
Disease	pseudohypoaldosteronism (implicated_via_orthology)	WNK1 WNK3 WNK2	2.54e-07	6	70	3	DOID:4479 (implicated_via_orthology)
Disease	refractive error, age at onset, Myopia	FLT1 PINX1 GRIA4 SLC14A2 ZEB2	9.75e-05	193	70	5	EFO_0004847, HP_0000545, MONDO_0004892
Disease	Abnormality of refraction	FLT1 GLOD5 PINX1 GRIA4 PLCXD3 SLC4A4 SLC14A2 RGS3	1.91e-04	673	70	8	HP_0000539
Disease	total cholesterol measurement, diastolic blood pressure, triglyceride measurement, systolic blood pressure, hematocrit, ventricular rate measurement, glucose measurement, body mass index, high density lipoprotein cholesterol measurement	NRBP1 PLCG1 POLK	2.45e-04	51	70	3	EFO_0004340, EFO_0004348, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928
Disease	3-methyl-2-oxobutyrate measurement	FAT4 ANKRD50	2.47e-04	10	70	2	EFO_0021020
Disease	Colorectal Carcinoma	DPAGT1 DPYD CFTR RBP3 OBSCN WNK1 ZEB2 FBXW7	2.54e-04	702	70	8	C0009402
Disease	complement component C7 measurement	MROH2B PLCXD3	3.61e-04	12	70	2	EFO_0008093
Disease	complement component C6 measurement	MROH2B PLCXD3	4.25e-04	13	70	2	EFO_0020281
Disease	coronary artery disease	DPYD FAT4 FLT1 CFTR RP1 PLCG1 ANKRD50 SLC14A2 ZEB2 WNK2	4.95e-04	1194	70	10	EFO_0001645
Disease	beta-amyloid 1-42 measurement, cerebrospinal fluid biomarker measurement	FAT4 ANKRD50	4.96e-04	14	70	2	EFO_0004670, EFO_0006794
Disease	anemia (implicated_via_orthology)	SLC4A4 SLC4A5	5.71e-04	15	70	2	DOID:2355 (implicated_via_orthology)
Disease	total cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer	NRBP1 PLCG1 POLK	5.99e-04	69	70	3	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Disease	central nervous system disease (implicated_via_orthology)	GRIA3 GRIA4	6.52e-04	16	70	2	DOID:331 (implicated_via_orthology)
Disease	Retinitis pigmentosa	PDE6A RBP3 RP1	7.35e-04	74	70	3	cv:C0035334
Disease	Hemangiosarcoma	FLT1 PLCG1	8.28e-04	18	70	2	C0018923
Disease	Hepatitis	FAT4 ANKRD50	1.24e-03	22	70	2	HP_0012115
Disease	Ischemic stroke, coronary artery disease	NCAM2 RP1 SLC14A2	1.38e-03	92	70	3	EFO_0001645, HP_0002140
Disease	Retinitis Pigmentosa	PDE6A RBP3 RP1	1.96e-03	104	70	3	C0035334
Disease	pathological myopia	AP1B1 PLPPR5 ZEB2	2.36e-03	111	70	3	EFO_0004207

Protein segments in the cluster

Peptide	Gene	Start	Entry
MAAVYSGISLKLKSK	URB2	1	Q14146
YLQKGKSARSVFKIM	URB2	951	Q14146
YRMAKTLVFSKVKTS	ACSBG2	371	Q5FVE4
ISAGTYFTMKVSKTK	AKAP14	131	Q86UN6
MFSLIYKKTLKLSSR	CFTR	156	P13569
SVKKMILTFEKRSYK	CTNNBL1	81	Q8WYA6
GLFISYVMLKTKRVT	DPM2	66	O94777
RKIMRTLYKKSSSEG	GJA10	236	Q969M2
LGSGTYKLTTMKKVS	FAT4	4041	Q6V0I7
AVKKGSYDMVSTLIK	ASB15	151	Q8WXK1
DRKMLKFISGIFTKS	AGAP2	341	Q99490
MTLSTLKEKGYKAAF	DPYD	266	Q12882
MTDSKYFTTTKKGEI	AP1B1	1	Q10567
RKQSKAVTKMFTGFR	ANKRD50	236	Q9ULJ7
MYRLLTLKKSFATGR	RAD54L2	406	Q9Y4B4
STRGKKKSIFETYMS	DIS3L2	41	Q8IYB7
GKTESSSYFRRKEKM	CACNA1B	456	Q00975
FIYLAKSTKKTMLTL	ERMP1	641	Q7Z2K6
KSYTGLGKKSRLMKT	RGS3	501	P49796
MLLKGSTRFNKTKTF	LAMA3	2936	Q16787
SRFEGLKKISAYMKS	GSTM5	186	P46439
MGIYSIKKFGLTTSR	MCM5	266	P33992
KSIKDTTMFYSKILG	GLOD5	46	A6NK44
AKKRMYLLVQGTSTF	ARRDC5	146	A6NEK1
RLFYTAKAKKTGKVM	TMEM63C	276	Q9P1W3
RKSKGKFAFLLESTM	GRIA3	726	P42263
RLNIKTGKLEMSYSK	DPAGT1	306	Q9H3H5
MSYSKFKTKSLSFLG	DPAGT1	316	Q9H3H5
RKSKGKFAFLLESTM	GRIA4	716	P48058
LTMYITNTIKAKGTR	PLPPR5	206	Q32ZL2
FTVFSKGQKRKMKSL	PLXNA4	336	Q9HCM2
MFSLLVTGKLKRYFT	PDE6A	571	P16499
YMKFTKGKDLSSRSK	PINX1	126	Q96BK5
GILAITMKTFSKTYL	MS4A10	106	Q96PG2
KMVIITTKSVSRYRG	CXCL14	66	O95715
EYMSSGSLKQFLKKT	NRBP1	151	Q9UHY1
TIILKMATNYLSGKK	OR2AE1	76	Q8NHA4
YKDGKKLSFSSKVRM	OBSCN	1476	Q5VST9
MLINFLVKKKTTSFY	OR8J1	81	Q8NGP2
YKKILGTFQKLKSMS	CCDC106	186	Q9BWC9
RYKGVSKSVIKTMSI	DHX57	806	Q6P158
FYTKTTKMKRKLDHG	FBXW7	161	Q969H0
FFTLGIMLSYIRSKK	KCNE1	56	P15382
STSKGKVMLKEYSGR	RNF103	181	O00237
AYKVNILMSGKKTFS	S1PR3	91	Q99500
YLRGMAKKSLVSKVT	RP1	846	P56715
SFDRKKKSISLMYGG	SLA	246	Q13239
KKSISLMYGGSKRKS	SLA	251	Q13239
GLMFKVNTDYKSSLK	UTY	171	O14607
GMKYSYVLKIKILSA	NTN4	521	Q9HB63
VFTSMLKYLFGVKTK	SLC26A5	221	P58743
SGKKSLTKTDVMVIY	MROH2B	691	Q7Z745
ITLQMLYKLKTSKVF	STXBP5L	481	Q9Y2K9
RRYTTFSKRKTGIMK	SRF	156	P11831
GSKMRKSIEIIYAIT	NCAPG2	86	Q86XI2
MRKKYGSLSVKVARS	C10orf67	336	Q8IYJ2
FVSVFGTVAKKLMRK	PLCXD3	61	Q63HM9
LIYTYDKMKLKGSSI	TGFBRAP1	796	Q8WUH2
ERYGSKKSMVILTSS	RBP3	1131	P10745
TTNLKTYSTGRKMIL	NCAM2	446	O15394
AKSSKMYGTLRKGSV	RIPOR3	51	Q96MK2
TKRPGLMTKYSTSKK	POLK	841	Q9UBT6
VGTVMTLFYSKKSQR	PLCG1	31	P19174
FFGTYSMTLTLKKFK	SLC4A5	751	Q9BY07
SMTLTLKKFKFSRYF	SLC4A5	756	Q9BY07
IEKKTMEGRSSKVYF	RWDD2B	71	P57060
LGTYTSSMALKKFKT	SLC4A4	701	Q9Y6R1
KKRLSLMYSITKGYI	SLC9C2	736	Q5TAH2
TELMTSGTLKTYLKR	WNK1	301	Q9H4A3
SGTLKTYLKRFKVMK	WNK1	306	Q9H4A3
ELMTSGTLKTYLKRF	WNK2	276	Q9Y3S1
LSRKKIKKTESGMYA	ZEB2	986	O60315
TVAGKRSYRLSMKVK	FLT1	346	P17948
KRVSKALSYITGEMK	SLC14A2	551	Q15849
TSGTLKTYLKRFKVM	WNK3	231	Q9BYP7