Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	single-stranded DNA binding	WBP11 ERCC4 TERF1 TERF2 DMC1 NUCKS1	1.67e-04	134	121	6	GO:0003697
GeneOntologyMolecularFunction	RNA polymerase I core binding	RRN3 SPTY2D1	2.17e-04	4	121	2	GO:0001042
GeneOntologyBiologicalProcess	protection from non-homologous end joining at telomere	ERCC4 TFIP11 TERF2	3.14e-05	11	121	3	GO:0031848
GeneOntologyBiologicalProcess	negative regulation of telomeric D-loop disassembly	TERF1 TERF2	3.41e-05	2	121	2	GO:1905839
GeneOntologyBiologicalProcess	regulation of telomeric D-loop disassembly	TERF1 TERF2	3.41e-05	2	121	2	GO:1905838
GeneOntologyBiologicalProcess	negative regulation of telomeric loop disassembly	TERF1 TERF2	3.41e-05	2	121	2	GO:1904534
GeneOntologyBiologicalProcess	regulation of telomere maintenance via semi-conservative replication	TERF1 TERF2	3.41e-05	2	121	2	GO:0032213
GeneOntologyBiologicalProcess	negative regulation of telomere maintenance via semi-conservative replication	TERF1 TERF2	3.41e-05	2	121	2	GO:0032214
GeneOntologyBiologicalProcess	negative regulation of exonuclease activity	TERF1 TERF2	3.41e-05	2	121	2	GO:1905778
GeneOntologyBiologicalProcess	regulation of exonuclease activity	TERF1 TERF2	3.41e-05	2	121	2	GO:1905777
GeneOntologyBiologicalProcess	telomere capping	ERCC4 TFIP11 TERF1 TERF2	9.65e-05	41	121	4	GO:0016233
GeneOntologyBiologicalProcess	regulation of telomeric loop disassembly	TERF1 TERF2	1.02e-04	3	121	2	GO:1904533
Domain	Telomere_repeat-bd_fac_dimer	TERF1 TERF2	3.96e-05	2	118	2	PD014243
Domain	TRF	TERF1 TERF2	3.96e-05	2	118	2	PF08558
Domain	Telomere_rpt-bd_fac_dimer_dom	TERF1 TERF2	3.96e-05	2	118	2	IPR013867
Domain	-	TERF1 TERF2	3.96e-05	2	118	2	1.25.40.210
Domain	FAM43A/B_PTB	FAM43B FAM43A	3.96e-05	2	118	2	IPR033930
Domain	TERF1	TERF1 TERF2	3.96e-05	2	118	2	IPR017357
Domain	PTB	FAM43B MAPK8IP2 FAM43A ANKS1A	1.16e-04	40	118	4	SM00462
Domain	PID_2	FAM43B FAM43A	1.18e-04	3	118	2	PF14719
Domain	PTB/PI_dom	FAM43B MAPK8IP2 FAM43A ANKS1A	1.28e-04	41	118	4	IPR006020
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SECISBP2L WBP11 ZNF143 ERCC4 RBBP5 TUT7 OBSL1 GON4L TFIP11 ZNFX1 GIGYF1 COLGALT2 RBM20 SYDE1 SLC4A2 ARHGEF40 RNF216	1.23e-10	650	121	17	38777146
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SETD1A RBBP5 ANP32B RBM26 BUD13 TFIP11 CHD4 SSRP1 SLC4A1AP SAFB2 SPTY2D1	1.41e-09	251	121	11	31076518
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FLII FLNA ARID4A FNBP4 ZMYM2 BUD13 TFIP11 CHD4 SSRP1 TERF2 PRDM2 SLC4A1AP SAFB2 NUCKS1 PKN1 EIF3B ANKS1A	1.73e-09	774	121	17	15302935
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MAGI1 FLII WBP11 TRAF3IP1 ADGRB2 WDR81 ZMYM2 ZNFX1 CHD4 UBE2O CELSR2 SAFB2 PKN1 HERC2 MAPK8IP2 BEGAIN ANKS1A	4.28e-08	963	121	17	28671696
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SECISBP2L FLII FLNA WBP11 TUT7 PEG3 RBM26 FNBP4 OBSL1 TFIP11 CHD4 LARP1B SSRP1 WDR3 ARHGEF40 USO1 TIMM50 KLHL12 HERC2 SPTY2D1	5.69e-08	1371	121	20	36244648
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP34 FLII WBP11 TRAF3IP1 PEG3 OBSL1 ZMYM2 TFIP11 ZNFX1 CHD4 NCAPH2 TERF1 WDR3 TRIM33 UBE2O RNF216 HERC2 MAPK8IP2	5.10e-07	1285	121	18	35914814
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	FLNA WBP11 ZNF143 ARID4A RBM26 FNBP4 ZMYM2 BUD13 TFIP11 CHD4 SSRP1 WDR3 TRIM33 SLC4A1AP SAFB2	1.21e-06	954	121	15	36373674
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	FLII FLNA PDE4D RBM26 ZMYM2 GIGYF1 TERF2 RBSN NUCKS1 PKN1 BEGAIN	1.59e-06	503	121	11	16964243
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ZBTB17 ARID4A RBBP5 FNBP4 ZMYM2 TFIP11 CHD4 NCAPH2 SSRP1 TERF1 TERF2 PRDM2 WDR3 ZBTB39 TIMM50 SAFB2 SPTY2D1	2.59e-06	1294	121	17	30804502
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SETD1A ERCC4 RBBP5 TUT7 FNBP4 LMTK2 CHD4 SSRP1 WDR3 HERC2	3.44e-06	440	121	10	34244565
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	USP34 ERCC4 ZMYM2 TRIM33 ZBTB39 USO1 GET3 RNF216	4.03e-06	262	121	8	36880596
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	FLII FLNA PDE4D TUT7 ZNFX1 ARHGEF40 HERC2	7.25e-06	202	121	7	33005030
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FLII FLNA ZNF280D RBBP5 ANP32B RBM26 CHD4 SSRP1 PRDM2 WDR3 UBE2O USO1 TIMM50 SAFB2 NUCKS1 SAMM50 EIF3B	9.24e-06	1425	121	17	30948266
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	FLNA WBP11 ANP32B RBM26 ZMYM2 TFIP11 CHD4 SSRP1 WDR3 TRIM33 SLC4A1AP TIMM50 SAFB2 SPTY2D1	9.31e-06	989	121	14	36424410
Pubmed	Human transcription factor protein interaction networks.	SETD1A WBP11 ZNF143 ERCC4 ARID4A RBBP5 ZMYM2 GON4L TFIP11 GIGYF1 RBM20 PRDM2 TRIM33 UBE2O TIMM50 EIF3B HERC2	9.58e-06	1429	121	17	35140242
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	USP34 WBP11 SEM1 TUT7 RBM26 TFIP11 PCDH17 SLC4A2 UBE2O USO1 NUCKS1 ANKS1A	1.01e-05	733	121	12	34672954
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	FLII FLNA WBP11 FNBP4 TFIP11 CHD4 UBE2O SLC4A1AP NUCKS1 EIF3B	1.16e-05	506	121	10	30890647
Pubmed	XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer.	ERCC4 TERF2	1.20e-05	2	121	2	16142233
Pubmed	TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops.	TERF1 TERF2	1.20e-05	2	121	2	29358759
Pubmed	Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.	ADCY5 PKD2	1.20e-05	2	121	2	29042084
Pubmed	Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.	TERF1 TERF2	1.20e-05	2	121	2	11545737
Pubmed	The ubiquitin specific protease USP34 protects the ubiquitin ligase gp78 from proteasomal degradation.	USP34 AMFR	1.20e-05	2	121	2	30585151
Pubmed	A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans.	FOXN1 FGFR3	1.20e-05	2	121	2	19729838
Pubmed	A two-step mechanism for TRF2-mediated chromosome-end protection.	TERF1 TERF2	1.20e-05	2	121	2	23389450
Pubmed	Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2.	TERF1 TERF2	1.20e-05	2	121	2	11971978
Pubmed	Novel modified tripeptide inhibitors of alpha 4 beta 7 mediated lymphoid cell adhesion to MAdCAM-1.	ITGA4 MADCAM1	1.20e-05	2	121	2	9873398
Pubmed	Control of human telomere length by TRF1 and TRF2.	TERF1 TERF2	1.20e-05	2	121	2	10669743
Pubmed	The role of telomere binding molecules for normal and abnormal hematopoiesis.	TERF1 TERF2	1.20e-05	2	121	2	29550946
Pubmed	Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats.	TERF1 TERF2	1.20e-05	2	121	2	15007108
Pubmed	Genetic variation in telomeric repeat binding factors 1 and 2 in aplastic anemia.	TERF1 TERF2	1.20e-05	2	121	2	16647572
Pubmed	How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures.	TERF1 TERF2	1.20e-05	2	121	2	15608617
Pubmed	The alpha(4) integrin subunit Tyr(187) has a key role in alpha(4)beta(7)-dependent cell adhesion.	ITGA4 MADCAM1	1.20e-05	2	121	2	10702270
Pubmed	In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2.	TERF1 TERF2	1.20e-05	2	121	2	36142374
Pubmed	Persistent telomere cohesion protects aged cells from premature senescence.	TERF1 TERF2	1.20e-05	2	121	2	32620872
Pubmed	Charge-based interaction conserved within histone H3 lysine 4 (H3K4) methyltransferase complexes is needed for protein stability, histone methylation, and gene expression.	SETD1A RBBP5	1.20e-05	2	121	2	22147691
Pubmed	The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human.	TERF1 TERF2	1.20e-05	2	121	2	8614633
Pubmed	Expression Analysis of the Stem Cell Marker Pw1/Peg3 Reveals a CD34 Negative Progenitor Population in the Hair Follicle.	FOXN1 PEG3	1.20e-05	2	121	2	27862634
Pubmed	The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats.	TERF1 TERF2	1.20e-05	2	121	2	21423270
Pubmed	Condensin II subunit NCAPH2 associates with shelterin protein TRF1 and is required for telomere stability.	NCAPH2 TERF1	1.20e-05	2	121	2	31026066
Pubmed	Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.	TERF1 TERF2	1.20e-05	2	121	2	9326950
Pubmed	Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters.	TERF1 TERF2	1.20e-05	2	121	2	28808664
Pubmed	Molecular Consequences of Depression Treatment: A Potential In Vitro Mechanism for Antidepressants-Induced Reprotoxic Side Effects.	TERF1 TERF2	1.20e-05	2	121	2	34769286
Pubmed	Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia.	TERF1 TERF2	1.20e-05	2	121	2	16786598
Pubmed	Compartmentalization of telomeres through DNA-scaffolded phase separation.	TERF1 TERF2	1.20e-05	2	121	2	35077681
Pubmed	Filamin-a increases the stability and plasma membrane expression of polycystin-2.	FLNA PKD2	1.20e-05	2	121	2	25861040
Pubmed	Expression of telomere repeat binding factor 1 and TRF2 in Alzheimer's disease and correlation with clinical parameters.	TERF1 TERF2	1.20e-05	2	121	2	30761946
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	USP34 WBP11 RBBP5 ANP32B RBM26 CHD4 SSRP1 WDR3 TRIM33 BTF3 NAE1 SAFB2 NUCKS1 EIF3B	1.23e-05	1014	121	14	32416067
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	ERCC4 RBM26 ZMYM2 NCAPH2 TERF2 TRIM33 SPTY2D1	1.34e-05	222	121	7	37071664
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	FLII FLNA WBP11 RBBP5 RBM26 SSRP1 USO1 TIMM50 SAFB2 NUCKS1 EIF3B	1.86e-05	653	121	11	33742100
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	AMFR TRIM33 TRIM55 RNF216 HERC2	2.12e-05	95	121	5	29643511
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	SECISBP2L FLNA WBP11 TUT7 RBM26 ZNFX1 LARP1B SSRP1 UBE2O BTF3 SAFB2 NUCKS1	2.61e-05	807	121	12	22681889
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF143 ZBTB17 ZNF280D MYT1 TUT7 PEG3 RBM26 ZMYM2 SSRP1 TERF1 GTF2A1 TCF7L1	2.64e-05	808	121	12	20412781
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	WBP11 RBBP5 BUD13 TFIP11 SSRP1 SAFB2 SDC4	2.94e-05	251	121	7	28077445
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	FLNA WBP11 ZNF143 RBM26 ZMYM2 CHD4 SSRP1 PRDM2 TRIM33 ZBTB39 BTF3 NAE1 SAFB2 NUCKS1	3.11e-05	1103	121	14	34189442
Pubmed	Structure, dynamics, and regulation of TRF1-TIN2-mediated trans- and cis-interactions on telomeric DNA.	TERF1 TERF2	3.59e-05	3	121	2	34403696
Pubmed	The structurally similar TRFH domain of TRF1 and TRF2 dimers shows distinct behaviour towards TIN2.	TERF1 TERF2	3.59e-05	3	121	2	29428209
Pubmed	Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain.	SETD1A RASSF10	3.59e-05	3	121	2	29490266
Pubmed	Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers.	TERF1 TERF2	3.59e-05	3	121	2	12530079
Pubmed	BRM-SWI/SNF chromatin remodeling complex enables functional telomeres by promoting co-expression of TRF2 and TRF1.	TERF1 TERF2	3.59e-05	3	121	2	32502208
Pubmed	Modulation of telomere shelterin by TRF1 [corrected] and TRF2 interacts with telomerase to maintain the telomere length in non-small cell lung cancer.	TERF1 TERF2	3.59e-05	3	121	2	17681636
Pubmed	Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms.	ERCC4 TERF2	3.59e-05	3	121	2	18812185
Pubmed	Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.	TERF1 TERF2	3.59e-05	3	121	2	23604072
Pubmed	Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.	ADCY5 PKD2	3.59e-05	3	121	2	27826057
Pubmed	TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis.	ERCC4 TERF1	3.59e-05	3	121	2	19124610
Pubmed	Alpha4beta7/MAdCAM-1 interactions play an essential role in transitioning cryptopatches into isolated lymphoid follicles and a nonessential role in cryptopatch formation.	ITGA4 MADCAM1	3.59e-05	3	121	2	18768861
Pubmed	Telomeres and chromosomal instability in chronic lymphocytic leukemia.	TERF1 TERF2	3.59e-05	3	121	2	22878603
Pubmed	Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis.	TERF1 TERF2	3.59e-05	3	121	2	15632001
Pubmed	An integrin alpha4beta7•IgG heterodimeric chimera binds to MAdCAM-1 on high endothelial venules in gut-associated lymphoid tissue.	ITGA4 MADCAM1	3.59e-05	3	121	2	21430257
Pubmed	Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation.	TERF1 TERF2	3.59e-05	3	121	2	18178559
Pubmed	AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.	TERF1 TERF2	3.59e-05	3	121	2	26110528
Pubmed	AKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2.	CACNA1C ADCY5	3.59e-05	3	121	2	33082339
Pubmed	Telomere proteins POT1, TRF1 and TRF2 augment long-patch base excision repair in vitro.	TERF1 TERF2	3.59e-05	3	121	2	22336916
Pubmed	The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.	TERF1 TERF2	3.59e-05	3	121	2	15200954
Pubmed	Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.	ITGA4 MADCAM1	3.59e-05	3	121	2	7687523
Pubmed	Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇.	ITGA4 MADCAM1	3.59e-05	3	121	2	23986478
Pubmed	Heparin II domain of fibronectin uses alpha4beta1 integrin to control focal adhesion and stress fiber formation, independent of syndecan-4.	ITGA4 SDC4	3.59e-05	3	121	2	15572366
Pubmed	The CC' and DE loops in Ig domains 1 and 2 of MAdCAM-1 play different roles in MAdCAM-1 binding to low- and high-affinity integrin alpha4beta7.	ITGA4 MADCAM1	3.59e-05	3	121	2	21296888
Pubmed	Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2.	TERF1 TERF2	3.59e-05	3	121	2	15229185
Pubmed	Altered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma.	TERF1 TERF2	3.59e-05	3	121	2	20644899
Pubmed	The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.	TERF1 TERF2	3.59e-05	3	121	2	15314656
Pubmed	FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis.	TERF1 TERF2	3.59e-05	3	121	2	31724724
Pubmed	Defective stromal remodeling and neutrophil extracellular traps in lymphoid tissues favor the transition from autoimmunity to lymphoma.	FOXN1 SPARC	3.59e-05	3	121	2	24189145
Pubmed	Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.	RBBP5 TUT7 SHQ1 SPTY2D1	3.85e-05	54	121	4	26288249
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	FLII FLNA ZBTB17 ARID4A ZMYM2 CHD4 SSRP1 ZBTB39 TIMM50 EIF3B	3.88e-05	583	121	10	29844126
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	FLNA RBM26 ZMYM2 TFIP11 CHD4 SSRP1 WDR3	4.78e-05	271	121	7	32433965
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF280D ARID4A RBBP5 ZMYM2 CHD4 SSRP1 PRDM2 UBE2O SLC4A1AP HERC2	5.52e-05	608	121	10	36089195
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLII FLNA WBP11 OBSL1 CHD4 SSRP1 WDR3 GET3 TIMM50 SAFB2 EIF3B HERC2 SCIN	6.05e-05	1024	121	13	24711643
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	SETD1A ZNF280D RBBP5 ZMYM2 CHD4 UBE2O TIMM50 EIF3B FBXO33	6.16e-05	495	121	9	27705803
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RBBP5 RBM26 ZMYM2 GON4L BUD13 TFIP11 SSRP1 TERF2 WDR3 TRIM33 SLC4A1AP BTF3 EIF3B HERC2 SPTY2D1 SDC4	6.47e-05	1497	121	16	31527615
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	SECISBP2L RBM26 WDR81 ZNFX1 GIGYF1 SSRP1 CDC37L1 SYDE1 MKNK1 SHQ1 TRIM33 RNF216 BEGAIN	6.94e-05	1038	121	13	26673895
Pubmed	β7-Integrin exacerbates experimental DSS-induced colitis in mice by directing inflammatory monocytes into the colon.	ITGA4 MADCAM1	7.17e-05	4	121	2	26349655
Pubmed	Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases.	ADCY5 PKD2	7.17e-05	4	121	2	21670265
Pubmed	XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening.	ERCC4 TERF2	7.17e-05	4	121	2	17055345
Pubmed	Structural interaction and functional regulation of polycystin-2 by filamin.	FLNA PKD2	7.17e-05	4	121	2	22802962
Pubmed	Arginine methylation regulates telomere length and stability.	TERF1 TERF2	7.17e-05	4	121	2	19596784
Pubmed	Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.	TERF1 TERF2	7.17e-05	4	121	2	24120135
Pubmed	Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.	CACNA1C PDE4D	7.17e-05	4	121	2	21670503
Pubmed	Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells.	DRD5 ADCY5	7.17e-05	4	121	2	25049074
Pubmed	Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells.	TERF2 GTF2A1	7.17e-05	4	121	2	10570139
Pubmed	Antagonizing functions of BARD1 and its alternatively spliced variant BARD1δ in telomere stability.	TERF1 TERF2	7.17e-05	4	121	2	28030839
Interaction	TMSB4Y interactions	WBP11 BUD13 TERF1 SAFB2 SPTY2D1	3.37e-06	39	120	5	int:TMSB4Y
Interaction	MCM7 interactions	SETD1A OBSL1 RASSF10 TFIP11 ITGA4 SSRP1 TERF1 TERF2 TRIM33 BTF3 TRIM55 NUCKS1	6.88e-06	414	120	12	int:MCM7
Interaction	H2BC8 interactions	ERCC4 ZNF280D ARID4A RBBP5 ZMYM2 GON4L BUD13 CHD4 ITGA4 SSRP1 TERF2 UBE2O SLC4A1AP NUCKS1	8.60e-06	576	120	14	int:H2BC8
Interaction	MYH10 interactions	FLII AMFR CHD4 ITGA4 TERF2 WDR3 TRIM33 UBE2O BTF3 EIF3B HERC2	1.01e-05	359	120	11	int:MYH10
Interaction	PRKDC interactions	FLII SETD1A FLNA OBSL1 LMTK2 CHD4 ITGA4 SSRP1 TERF1 MKNK1 TRIM33 UBE2O BTF3 NUCKS1 FGFR3	1.65e-05	695	120	15	int:PRKDC
Interaction	H2BC21 interactions	ZNF280D ARID4A RBBP5 FNBP4 OBSL1 ZMYM2 ARHGAP30 CHD4 SSRP1 TERF2 PRDM2 BTF3 SAFB2 NUCKS1 HCLS1	1.67e-05	696	120	15	int:H2BC21
Interaction	H4C12 interactions	OBSL1 CHD4 ITGA4 SSRP1 SPTY2D1	1.72e-05	54	120	5	int:H4C12
Interaction	RAD18 interactions	SETD1A ANP32B RBM26 ZMYM2 BUD13 TFIP11 CHD4 SSRP1 SLC4A1AP TIMM50 SAFB2 SPTY2D1	1.85e-05	457	120	12	int:RAD18
Interaction	NUP43 interactions	USP34 SETD1A FLNA ZNF280D ARID4A RBBP5 RBM26 ZMYM2 GON4L BUD13 SSRP1 TERF2 PRDM2 WDR3	2.14e-05	625	120	14	int:NUP43
Interaction	LINC02910 interactions	WBP11 RBM26 BUD13 TFIP11 TERF1 SAFB2	2.22e-05	95	120	6	int:LINC02910
Interaction	H3C15 interactions	WBP11 ANP32B OBSL1 CHD4 ITGA4 SSRP1 BTF3 NUCKS1	3.40e-05	207	120	8	int:H3C15
Interaction	MDC1 interactions	AMFR FLNA ERCC4 OBSL1 CHD4 TERF1 TERF2 TRIM33 SLC4A1AP NUCKS1 HERC2	3.76e-05	414	120	11	int:MDC1
Interaction	RBBP4 interactions	FLII SETD1A FLNA ARID4A RBBP5 OBSL1 ZMYM2 RASSF10 CHD4 SSRP1 BTF3 NUCKS1 FAM43A	3.76e-05	573	120	13	int:RBBP4
Interaction	THOC1 interactions	RBM26 OBSL1 TFIP11 CHD4 SSRP1 TRIM33 UBE2O SLC4A1AP	3.77e-05	210	120	8	int:THOC1
Interaction	H3C14 interactions	SETD1A ARID4A RBBP5 OBSL1 CHD4 ITGA4 PKN1	4.16e-05	156	120	7	int:H3C14
Interaction	CDC25C interactions	MAGI1 FLNA LMTK2 GIGYF1 SYDE1 PKN1 HERC2	4.16e-05	156	120	7	int:CDC25C
Interaction	KDM1A interactions	USP34 FLII FLNA ZNF280D RBBP5 MYT1 OBSL1 ZMYM2 TFIP11 CHD4 TERF1 RBM20 PRDM2 ZBTB39 SLC4A1AP USO1 TIMM50	4.23e-05	941	120	17	int:KDM1A
Interaction	SUMO2 interactions	FLNA ERCC4 SEM1 ANP32B ZMYM2 CHD4 NCAPH2 SSRP1 ABCA8 TRIM33 ZBTB39 SAFB2 RNF216	5.16e-05	591	120	13	int:SUMO2
Interaction	DISC1 interactions	FLII FLNA TRAF3IP1 RBBP5 PPM1E TFIP11 COLGALT2 RBSN GET3 PKN1 HERC2	5.19e-05	429	120	11	int:DISC1
Interaction	EIF3A interactions	SEM1 OBSL1 TFIP11 CHD4 GIGYF1 ITGA4 SSRP1 TRIM33 EIF3B HERC2	5.29e-05	355	120	10	int:EIF3A
Interaction	H4C6 interactions	OBSL1 CHD4 ITGA4 SSRP1 SPTY2D1	5.71e-05	69	120	5	int:H4C6
Interaction	MTA2 interactions	FLII SETD1A RBBP5 OBSL1 ZMYM2 BUD13 CHD4 SSRP1 BTF3 NUCKS1 FAM43A	5.88e-05	435	120	11	int:MTA2
Interaction	KPNA2 interactions	FLII SETD1A RBBP5 OBSL1 CHD4 ITGA4 TERF1 TERF2 SYDE1 UBE2O SLC4A1AP NUCKS1	6.35e-05	519	120	12	int:KPNA2
Interaction	ACTC1 interactions	FLII FLNA WBP11 TRAF3IP1 FNBP4 OBSL1 TFIP11 CHD4 ITGA4 UBE2O SLC4A1AP NUCKS1 EIF3B SCIN	6.67e-05	694	120	14	int:ACTC1
Interaction	DNAJC9 interactions	ANP32B FNBP4 OBSL1 LMTK2 SSRP1 WDR3 UBE2O BTF3 FGFR3	7.09e-05	296	120	9	int:DNAJC9
Interaction	ILF3 interactions	SPARC ZNF143 OBSL1 GON4L BUD13 CHD4 ITGA4 LARP1B SSRP1 WDR3 TRIM33 BTF3 TRIM55 NUCKS1 FGFR3 SPTY2D1	8.31e-05	896	120	16	int:ILF3
Interaction	DCAF4 interactions	SECISBP2L USP34 SETD1A FLNA RBBP5 TUT7 LARP1B SSRP1 UBE2O ARHGEF40	8.91e-05	378	120	10	int:DCAF4
Interaction	CSNK2B interactions	RBBP5 OBSL1 RASSF10 APLP1 TFIP11 CHD4 ITGA4 SSRP1 TERF1 TERF2 UBE2O USO1 BTF3	9.09e-05	625	120	13	int:CSNK2B
Interaction	SIRT6 interactions	SETD1A FLNA ERCC4 RBBP5 TUT7 FNBP4 LMTK2 CHD4 SSRP1 WDR3 CELSR2 HERC2 ANKS1A	9.53e-05	628	120	13	int:SIRT6
Interaction	SRRM2 interactions	FLNA WBP11 RBBP5 OBSL1 RASSF10 CHD4 SSRP1 TERF2 UBE2O BTF3 EIF3B	1.00e-04	462	120	11	int:SRRM2
Interaction	ARHGAP10 interactions	SETD1A ARHGAP30 PKN1 ANKS1A	1.02e-04	41	120	4	int:ARHGAP10
Interaction	EED interactions	FLII FLNA WBP11 ANP32B PEG3 ZMYM2 TFIP11 CHD4 ITGA4 SSRP1 PRDM2 WDR3 USO1 GET3 TIMM50 TRIM55 SAFB2 NUCKS1 SAMM50 EIF3B HERC2	1.17e-04	1445	120	21	int:EED
Interaction	ATN1 interactions	MAGI1 SETD1A RBBP5 GIGYF1 TERF1 TERF2 MEGF6	1.30e-04	187	120	7	int:ATN1
Interaction	GMEB1 interactions	ZMYM2 SSRP1 TRIM55 SDC4	1.48e-04	45	120	4	int:GMEB1
Interaction	ZNF460 interactions	USP34 ZMYM2 CHD4 TRIM33 UBE2O TRIM55	1.78e-04	138	120	6	int:ZNF460
Interaction	NUP50 interactions	SETD1A WBP11 RBM26 FNBP4 TFIP11 WDR3 TRIM33 GTF2A1 SLC4A1AP	2.06e-04	341	120	9	int:NUP50
Interaction	FBXO47 interactions	TERF1 TERF2	2.09e-04	4	120	2	int:FBXO47
Interaction	HHIPL2 interactions	UBE2O ALOX5	2.09e-04	4	120	2	int:HHIPL2
Interaction	LRRC31 interactions	FLII FLNA PDE4D TUT7 ZNFX1 ARHGEF40 HERC2	2.29e-04	205	120	7	int:LRRC31
Interaction	EMSY interactions	RBBP5 NCAPH2 AIDA UBE2O GET3 NUCKS1	2.33e-04	145	120	6	int:EMSY
Interaction	DDX17 interactions	WBP11 FNBP4 OBSL1 TFIP11 CHD4 ITGA4 SSRP1 TRIM33 UBE2O BTF3	2.35e-04	426	120	10	int:DDX17
Interaction	TOP1 interactions	RBBP5 SEM1 OBSL1 BUD13 CHD4 ITGA4 SSRP1 TERF2 UBE2O BTF3 SAFB2 HERC2 SPTY2D1	2.62e-04	696	120	13	int:TOP1
Interaction	DDB1 interactions	SETD1A FLNA RBBP5 OBSL1 WDR81 RASSF10 TFIP11 SSRP1 TERF1 TERF2 WDR3 UBE2O NUCKS1	2.65e-04	697	120	13	int:DDB1
Interaction	FGFRL1 interactions	SETD1A TERF2 UBE2O CELSR2	2.79e-04	53	120	4	int:FGFRL1
Interaction	PARP1 interactions	MAGI1 FLII SETD1A ASRGL1 ERCC4 ANP32B OBSL1 LMTK2 CHD4 ITGA4 SSRP1 PRDM2 WDR3 TRIM33 UBE2O USO1 BTF3 GET3 NUCKS1	2.81e-04	1316	120	19	int:PARP1
Interaction	SMC5 interactions	FLNA WBP11 ZNF143 ARID4A RBM26 FNBP4 ZMYM2 BUD13 TFIP11 CHD4 SSRP1 TERF2 WDR3 TRIM33 SLC4A1AP SAFB2	2.91e-04	1000	120	16	int:SMC5
Interaction	PYHIN1 interactions	WBP11 RBBP5 ZMYM2 BUD13 TFIP11 CHD4 SSRP1 SAFB2 SDC4	2.95e-04	358	120	9	int:PYHIN1
Interaction	H4C2 interactions	OBSL1 CHD4 ITGA4 SSRP1	3.00e-04	54	120	4	int:H4C2
Interaction	RAI1 interactions	CHD4 SSRP1 NUCKS1 HERC2 MAPK8IP2	3.30e-04	100	120	5	int:RAI1
Interaction	PHF14 interactions	GON4L CHD4 SSRP1 NUCKS1 EIF3B	3.30e-04	100	120	5	int:PHF14
Interaction	SMARCB1 interactions	FOXN1 FLII RBBP5 TFIP11 CHD4 SSRP1 NUCKS1 SAMM50 MAPK8IP2	3.33e-04	364	120	9	int:SMARCB1
Interaction	RBM15B interactions	RBBP5 SEM1 CHD4 TERF1 TERF2	3.46e-04	101	120	5	int:RBM15B
Interaction	NXNL1 interactions	TERF1 TERF2	3.48e-04	5	120	2	int:NXNL1
Interaction	WDR82P1 interactions	SETD1A RBBP5	3.48e-04	5	120	2	int:WDR82P1
Interaction	HNRNPUL2 interactions	OBSL1 LMTK2 TFIP11 CHD4 LARP1B SSRP1 SAFB2 FGFR3	3.57e-04	291	120	8	int:HNRNPUL2
Interaction	DHX8 interactions	FLNA WBP11 RBM26 FNBP4 OBSL1 BUD13 TFIP11 CHD4	3.65e-04	292	120	8	int:DHX8
Interaction	H2AZ1 interactions	RBBP5 ANP32B OBSL1 ZMYM2 CHD4 SSRP1 BTF3 NUCKS1 SDC4	3.83e-04	371	120	9	int:H2AZ1
Interaction	RYR2 interactions	CACNA1C TERF1 TERF2 RBM20	3.96e-04	58	120	4	int:RYR2
Interaction	H4C13 interactions	OBSL1 CHD4 ITGA4 SSRP1	3.96e-04	58	120	4	int:H4C13
Interaction	PELO interactions	FLNA ITGA4 TRIM33 UBE2O TIMM50 TRIM55	4.09e-04	161	120	6	int:PELO
Interaction	XRCC6 interactions	SPARC RBM26 OBSL1 TFIP11 CHD4 ITGA4 SSRP1 TERF2 CAVIN4 GTF2A1 UBE2O BTF3 NAE1 TIMM50 SAFB2	4.10e-04	928	120	15	int:XRCC6
Interaction	SNRNP40 interactions	FLNA WBP11 ZNF280D OBSL1 GON4L BUD13 TFIP11 SSRP1 RBM20 WDR3 SLC4A1AP SPTY2D1	4.22e-04	637	120	12	int:SNRNP40
Interaction	FBL interactions	TUT7 OBSL1 CHD4 ITGA4 LARP1B SSRP1 TERF2 WDR3 UBE2O ARHGEF40 BTF3 SPTY2D1	4.34e-04	639	120	12	int:FBL
Interaction	TBC1D25 interactions	MAGI1 GIGYF1 LARP1B SYDE1	4.51e-04	60	120	4	int:TBC1D25
Interaction	ARPC4 interactions	FLNA TUT7 ITGA4 UBE2O BTF3 HERC2	4.65e-04	165	120	6	int:ARPC4
Interaction	H4C9 interactions	OBSL1 CHD4 ITGA4 SSRP1 SPTY2D1	4.71e-04	108	120	5	int:H4C9
Interaction	DDX41 interactions	OBSL1 TFIP11 CHD4 AIDA UBE2O HERC2	4.81e-04	166	120	6	int:DDX41
Interaction	GTF2A2 interactions	TERF1 TERF2 GTF2A1	4.84e-04	26	120	3	int:GTF2A2
Interaction	ACTR3 interactions	FLII FLNA ANP32B OBSL1 SYDE1 UBE2O BTF3 HCLS1	4.87e-04	305	120	8	int:ACTR3
Interaction	BRCA2 interactions	FLNA SEM1 PPM1E CHD4 NCAPH2 SSRP1 TERF1 TERF2 DMC1	4.91e-04	384	120	9	int:BRCA2
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	WBP11 RBM26 WDR81 LMTK2 PPP1R3G PPP1R1C	1.73e-04	181	82	6	694
GeneFamily	Myb/SANT domain containing\|Shelterin complex	TERF1 TERF2	3.01e-04	6	82	2	1334
GeneFamily	Gelsolin/villins	FLII SCIN	5.59e-04	8	82	2	950
GeneFamily	Doublecortin superfamily	DCDC2C RP1L1	8.93e-04	10	82	2	1369
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	GON4L TERF1 TERF2	1.79e-03	53	82	3	532
GeneFamily	RNA binding motif containing	SETD1A RBM26 RBM20 SAFB2 EIF3B	2.83e-03	213	82	5	725
Coexpression	GSE16385_MONOCYTE_VS_12H_IL4_TREATED_MACROPHAGE_UP	CACNA1C ZNF280D BMF COLGALT2 ADCY5 PKN1 SDC4 FAM43A	4.30e-06	200	121	8	M7903
Coexpression	TABULA_MURIS_SENIS_BRAIN_NON_MYELOID_NEURON_AGEING	FLNA SPARC OBSL1 CHD4 GIGYF1 TERF1 ADCY5 RNF157 SHQ1 UBE2O ARHGEF40 GET3 SAFB2 SDC4 BEGAIN ANKS1A	8.37e-06	954	121	16	MM3689
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	SECISBP2L CACNA1C PDE4D ARID4A MYT1 PEG3 RBM26 APLP1 GIGYF1 LARP1B FAM43B PCDH17 RNF157 PRDM2 MEGF6 SCIN MAPK8IP2	1.33e-05	1106	121	17	M39071
Coexpression	RIGGI_EWING_SARCOMA_PROGENITOR_UP	PEG3 COLGALT2 ITGA4 FAM43B CDC37L1 PCDH17 SCIN TCF7L1 FAM43A ANKS1A	3.65e-05	437	121	10	M15981
Coexpression	GSE25088_IL4_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_DAY10_UP	SECISBP2L BMF ARHGAP30 RNF157 GTF2A1 NUCKS1 TXNDC16	4.11e-05	200	121	7	M7981
Coexpression	GSE36009_UNSTIM_VS_LPS_STIM_DC_DN	ANP32B WDR81 ZMYM2 ARHGAP30 TERF1 TRIM33 HCLS1	4.11e-05	200	121	7	M8774
ToppCell	facs-Lung-EPCAM-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA TMEM51 ARHGAP30 ITGA4 ALOX5 HCLS1 IL27	3.08e-07	162	121	7	484ea4ac40de672dcbd2583a52cb7f385c918814
ToppCell	facs-Lung-EPCAM-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA TMEM51 ARHGAP30 ITGA4 ALOX5 HCLS1 IL27	3.08e-07	162	121	7	bba144ac5332bab9eba2ccf599703c781a7f88f1
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 SPARC TUT7 PEG3 PCDH17 PRDM2 FAM43A	1.04e-06	194	121	7	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D122\|Adult / Lineage, Cell type, age group and donor	SECISBP2L MAGI1 PDE4D OBSL1 PPP1R1C FGFR3	4.53e-06	157	121	6	31d1bd9138c60e8485664ec4144f987226e3eef9
ToppCell	facs-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNA TMEM51 ARHGAP30 ITGA4 HCLS1 IL27	4.70e-06	158	121	6	121d63b8e2e37107467b170e5b2c798a7dbf6325
ToppCell	facs-Lung-18m-Hematologic-myeloid-non-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNA TMEM51 ARHGAP30 ITGA4 HCLS1 IL27	5.05e-06	160	121	6	bc4a93dc5f37829799c37877e751ff3bc122e4ab
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM51 PPM1E WDR81 ZNFX1 LARP1B RNF216	7.90e-06	173	121	6	0a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPARC ABCA8 PCDH17 CELSR2 MEGF6 KCNS3	1.02e-05	181	121	6	3aa81ac64d0cc9a74fbfa71e2176740548e7cd06
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature-Adult_Glia\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPARC ABCA8 PCDH17 CELSR2 MEGF6 KCNS3	1.02e-05	181	121	6	997ba1be2824b00d684f2163d0114656ed11fa53
ToppCell	10x3'2.3-week_12-13-Mesenchymal_myocytic\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	MAGI1 SPARC TUB RBM20 SCIN TCF7L1	1.02e-05	181	121	6	47dce04db3392333eb2f7b9b24c32e6740d2d02f
ToppCell	10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	MAGI1 SPARC TUB RBM20 SCIN TCF7L1	1.02e-05	181	121	6	19103221c3a5a16b16378348004b2c50caee4f01
ToppCell	5'-Adult-Appendix-Neuronal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPARC ABCA8 PCDH17 CELSR2 MEGF6 KCNS3	1.02e-05	181	121	6	e6b7e8dd5c13cc10ba22f2f5a8c669486f934bdc
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	USP34 TRAF3IP1 ARID4A TRIM33 GTF2A1 SPTY2D1	1.19e-05	186	121	6	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI1 SEMA4B PDE4D TMEM51 TRIM55 SCIN	1.43e-05	192	121	6	f7e7491426bbd6ed29a465b58bf67acb93dbb90a
ToppCell	facs-Marrow-B-cells-18m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ISLR2 SEMA4B PPM1E MINDY2 RNF157 FAM43A	1.51e-05	194	121	6	ad1aacff97beb76f4211942676e1d5e84087d44e
ToppCell	facs-Marrow-B-cells-18m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ISLR2 SEMA4B PPM1E MINDY2 RNF157 FAM43A	1.51e-05	194	121	6	fdd59b1e036b2d6d8877e1a920a0e56a91a2a882
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-early_osteoblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SPARC APLP1 RBM20 SYDE1 FGFR3 SCIN	1.65e-05	197	121	6	2ca5ebb708935a90b12b8e98a22ae2d664ed002e
ToppCell	Frontal_cortex-Neuronal\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	USP34 PEG3 UBE2O CELSR2 FBXO33 MAPK8IP2	1.75e-05	199	121	6	f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
Drug	Mepenzolate bromide [76-90-4]; Down 200; 9.6uM; PC3; HT_HG-U133A	AMFR PDE4D ERCC4 RBBP5 ZMYM2 CHD4 PRDM2 SCIN	7.86e-06	189	121	8	4304_DN
Drug	Spiramycin [8025-81-8]; Down 200; 4.8uM; PC3; HT_HG-U133A	AMFR RBBP5 ZMYM2 TFIP11 CHD4 NCAPH2 ENTPD4 GTF2A1	9.51e-06	194	121	8	4319_DN
Drug	Naringenine [480-41-1]; Down 200; 14.6uM; PC3; HT_HG-U133A	TRAF3IP1 PEG3 GON4L GTF2A1 ARHGEF40 CELSR2 SAFB2 MAPK8IP2	9.88e-06	195	121	8	4597_DN
Drug	Lactobionic acid [96-82-2]; Up 200; 11.2uM; HL60; HT_HG-U133A	USP34 FLII SETD1A AMFR CHD4 NCAPH2 PRDM2 SAFB2	1.06e-05	197	121	8	1309_UP
Drug	Enilconazole [35554-44-0]; Down 200; 13.4uM; MCF7; HT_HG-U133A	SECISBP2L AMFR ARID4A NCAPH2 SYDE1 PRDM2 GTF2A1 SAFB2	1.14e-05	199	121	8	5538_DN
Disease	uridine measurement	ERCC4 NCAPH2 FAM43B RBM20 PKD2	1.73e-07	32	118	5	EFO_0010546
Disease	age-related hearing impairment	MAGI1 FOXN1 ADGRB2 NCAPH2 FAM43B TUB WDR3 NUCKS1	4.98e-05	324	118	8	EFO_0005782
Disease	response to bronchodilator, FEV/FEC ratio	MAGI1 CACNA1C SPARC PDE4D ERCC4 PPM1E BUD13 ITGA4 RP1L1 NUCKS1 PKN1 FBXO33	5.95e-05	766	118	12	EFO_0004713, GO_0097366
Disease	erythrocyte measurement	USP34 RBBP5 BUD13 NCAPH2 ITGA4 RP1L1 ALOX5	8.12e-05	257	118	7	EFO_0005047
Disease	alcohol consumption measurement	SECISBP2L MAGI1 CACNA1C SETD1A ERCC4 ZNF280D ARID4A FNBP4 ITGA4 DMC1 NUCKS1 FBXO33 IL27 ANKS1A	4.49e-04	1242	118	14	EFO_0007878
Disease	1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4) measurement	BUD13 MINDY2	5.60e-04	9	118	2	EFO_0800409
Disease	cervix carcinoma (is_implicated_in)	SPARC FGFR3	6.99e-04	10	118	2	DOID:2893 (is_implicated_in)
Disease	craniosynostosis (is_implicated_in)	FLNA FGFR3	1.02e-03	12	118	2	DOID:2340 (is_implicated_in)
Disease	FEV/FEC ratio	USP34 TRAF3IP1 RBBP5 TUT7 BMF RASSF10 AIDA TRIM33 MEGF6 KCNS3 FGFR3 TCF7L1 SDC4	1.28e-03	1228	118	13	EFO_0004713
Disease	Testicular Germ Cell Tumor	FGFR3 ALOX5	1.40e-03	14	118	2	C1336708
Disease	cholesterol in medium HDL measurement	BUD13 ABCA8 CELSR2	1.72e-03	59	118	3	EFO_0021903
Disease	free cholesterol in IDL measurement	BUD13 CELSR2 RRN3	1.89e-03	61	118	3	EFO_0022181
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	BUD13 ABCA8 CELSR2 RRN3 SAMM50	2.15e-03	225	118	5	EFO_0008317, EFO_0020947
Disease	lipid measurement, high density lipoprotein cholesterol measurement	OBSL1 BUD13 ABCA8 CELSR2 RP1L1 ALOX5	2.16e-03	330	118	6	EFO_0004529, EFO_0004612
Disease	Bladder Neoplasm	AMFR ERCC4 PRDM2 FGFR3	2.45e-03	140	118	4	C0005695
Disease	Malignant neoplasm of urinary bladder	AMFR ERCC4 PRDM2 FGFR3	2.52e-03	141	118	4	C0005684
Disease	alkaline phosphatase measurement	USP34 SEMA4B SEM1 WDR81 LARP1B FAM43B ADCY5 SLC4A1AP RP1L1 PKD2 NUCKS1	2.54e-03	1015	118	11	EFO_0004533
Disease	facial height measurement	TERF1 PCDH17 SCIN ANKS1A	2.58e-03	142	118	4	EFO_0007856
Disease	osteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty	COLGALT2 FGFR3	3.17e-03	21	118	2	EFO_0004616, EFO_0010726, EFO_1000786
Disease	non-small cell lung carcinoma	SECISBP2L BEGAIN ANKS1A	3.41e-03	75	118	3	EFO_0003060
Disease	depressive disorder (implicated_via_orthology)	PDE4D DRD5	3.48e-03	22	118	2	DOID:1596 (implicated_via_orthology)
Disease	urate measurement, bone density	ERCC4 SEM1 ENTPD4 ABCA8 PCDH17 USO1 KCNS3 TCF7L1	3.49e-03	619	118	8	EFO_0003923, EFO_0004531
Disease	Disproportionate short stature	FLNA OBSL1 FGFR3	3.68e-03	77	118	3	C0878659
Disease	obsolete Mendelian syndromes with cleft lip/palate	TXNDC16 PKN1	3.80e-03	23	118	2	MONDO_0015335

Protein segments in the cluster

Peptide	Gene	Start	Entry
VEDDDDDEPIFVGEI	ZNF280D	36	Q6N043
AESEVGRPEEEEAEA	ADGRB2	121	O60241
VGEEQELEAPETFSE	ERICH6	61	Q7L0X2
EEDDGDLPVVAEFVD	BUD13	71	Q9BRD0
LDANEAEPVFDEREG	SLC4A2	1216	P04920
DDDEVPDLVENFDEA	BTF3	186	P20290
DGEAEVEAEAELAPV	C16orf86	211	Q6ZW13
PEDFVDDVSEEELLG	EIF3B	156	P55884
QAIEELEGAAEPEEE	ARHGEF40	696	Q8TER5
EVPEEELDPEERDNF	ARID4A	301	P29374
AAEEEEEAEAAAFPA	BEGAIN	266	Q9BUH8
DAVEGAVVALEDDPE	ASRGL1	46	Q7L266
EPEEEEEEQAASQGG	CCDC96	46	Q2M329
AAPEAETERVEGEEE	CCDC96	156	Q2M329
RVEGAEDEEEEESFP	APLP1	236	P51693
LAPGEEENLEFEEDE	AIDA	121	Q96BJ3
EDQEAPDSDAEVDGV	ANP32B	151	Q92688
ELIIDFDANAEEEGP	ANKS1A	346	Q92625
EEEEEEEAAFPGEQG	CELSR2	2746	Q9HCU4
AQESANPEDEVDEFL	ADCY5	706	O95622
VVAEEPGFQDEEESL	DMC1	6	Q14565
NQEEDDDDIFDPPVD	CAVIN4	156	Q5BKX8
EGEEAEDQILADPAE	ISLR2	441	Q6UXK2
GEEPEEVAAEAEEAA	RASSF10	291	A6NK89
VDEVGEEEDFIVEPD	RBM20	911	Q5T481
EVEPDEEEFQEESLV	RBM26	971	Q5T8P6
EIVDGNDDHLFEIDP	PCDH17	626	O14917
EEDEEEEAVAGNPFI	RBSN	666	Q9H1K0
GNREVDNDEEEGPFD	DRD5	421	P21918
VGSEEEQEEEDEAPF	NUCKS1	111	Q9H1E3
EVEESDFVVLENEGP	OBSL1	846	O75147
SDNEEDDQFVVEAAP	TRAF3IP1	501	Q8TDR0
EATAEAEEKQPEEDF	FLII	966	Q13045
EEEEPQGDEDVLFRV	MADCAM1	171	Q13477
AGIVHAENEEEDDVP	MAGI1	231	Q96QZ7
EQELDFQGLEEEEEP	GIGYF1	326	O75420
FQGLEEEEEPSEGLE	GIGYF1	331	O75420
AAVPFLASDNEEEED	HERC2	2921	O95714
EEDDAEEQEGGVPQR	FAM43B	271	Q6ZT52
PAAEGEDDEEEVAAA	KIAA2026	21	Q5HYC2
DVDDPVLVEAEEDDF	MAPK8IP2	626	Q13387
DFDQGELADQDVDPV	FBXO33	496	Q7Z6M2
EEAVGEEEESQPEAC	PDE4D	786	Q08499
DNFDDEIDFTPPAED	LMTK2	81	Q8IWU2
QNEDGEVDDPVLEGV	KCNS3	211	Q9BQ31
GIEDPEEGEDQEIQV	PEG3	1486	Q9GZU2
EPEQTGADAAEDEEV	RBBP5	361	Q15291
AEAAEASVEEPGEEA	PPM1E	56	Q8WY54
QEQDPEPEEEAAVEG	PPM1E	81	Q8WY54
DEIQVDSEEPVFEAV	KLHL12	186	Q53G59
ITQAEDIDPENEDEG	CACNA1C	441	Q13936
EDEEIHENTPDFEGN	DCDC2C	326	A8MYV0
PDGSEVDVDVVENED	FLNA	1691	P21333
LAAGFNLPEEEEEEE	IL27	156	Q8NEV9
DGFEEVALPDVEEEE	GON4L	1801	Q3T8J9
CVEELEDDVFQPEDG	BMF	6	Q96LC9
AAEGDPAEEEAEAQR	FAM43A	286	Q8N2R8
DGFEDVAIGAPQEDD	ITGA4	381	P13612
EAEEFEDAPDVEPLE	GET3	11	O43681
VLPAEEELVEADEAG	FGFR3	356	P22607
AERDSEDDGEEPVVF	COLGALT2	31	Q8IYK4
SGEGPEFVEEEEEVA	CHD4	86	Q14839
GLGEEAEFVEVEPEA	SAMM50	21	Q9Y512
EDVVGPGQESDDFEL	SDC4	46	P31431
AEGEAEEESDFDVFP	CDC37L1	16	Q7L3B6
PEQEELDFLFDEEIE	LARP1B	406	Q659C4
NGEDNPEIAAAIEEE	PRDM2	141	Q13029
ENDSIEAAEGEQEPE	ARHGAP30	361	Q7Z6I6
EAAEGEQEPEAEALG	ARHGAP30	366	Q7Z6I6
EENELAEEPEALADG	MKNK1	416	Q9BUB5
LPQLFQDDDVGADEE	MEGF6	481	O75095
FNSEEGAENRVPEEE	MINDY2	191	Q8NBR6
VEDEDDDFLKGEVPQ	RRN3	601	Q9NYV6
EDEEVGEPRVTGDFE	SYDE1	686	Q6ZW31
GHPVEEEDELESGDQ	USO1	931	O60763
FAPLPEFEQEEDDGE	TRIM33	1086	Q9UPN9
PAGEQDAEGNDVIEE	RNF157	581	Q96PX1
FPDGEEEEEESQAQE	FNBP4	626	Q8N3X1
RHEQEDEPEGDYEEV	HCLS1	386	P14317
GDQVVEEDPELQDFV	ALOX5	496	P09917
IPGEFTQDDLAEDDV	SCIN	631	Q9Y6U3
EAFEEIPVDVAEAEA	FOXN1	156	O15353
SAFPEEEEGTNEREE	PPP1R1C	91	Q8WVI7
EDDDEAVVEVNIPGS	ENTPD4	241	Q9Y227
CPEVVEDGVADQTDE	SEMA4B	671	Q9NPR2
GLLEEDDEFEEFPAE	SEM1	11	P60896
GASEIPEEVVDDEEF	SHQ1	111	Q6PI26
EQSGEEEAEAPEVLE	SECISBP2L	1046	Q93073
QPEDEEDADERGVAV	PPP1R3G	311	B7ZBB8
EFEDQQLASDDEEPG	RNF216	241	Q9NWF9
PGDDEEEVFDSIVND	PKN1	816	Q16512
MEDFIEDEGEPQEEI	SPTY2D1	601	Q68D10
EEEEAEPGTEVDLAV	SETD1A	1241	O15047
SFNPGEEEEDVAEEF	SSRP1	481	Q08945
KEQELGDFEEDFDPS	ABCA8	1596	O94911
EETLDFGEVEVEPSE	AMFR	546	Q9UKV5
FGEVEVEPSEVEDFE	AMFR	551	Q9UKV5
GEDEDAEEAVELPEA	NCAPH2	256	Q6IBW4
DGQVEEEPLNSEDDV	GTF2A1	306	P52655
GPDIDVQDDEVAETV	TXNDC16	366	Q9P2K2
VDENGAKIPDEFDND	TIMM50	91	Q3ZCQ8
NDTEPIEEEQEAFFE	ZNF143	441	P52747
VEEVENVQTEFPGED	TRIM55	356	Q9BYV6
VEAPEAEGDAQEAEG	RP1L1	1851	Q8IWN7
QEAEGEAQPESEDVE	RP1L1	1861	Q8IWN7
EVEVETQEAEGEAQP	RP1L1	1981	Q8IWN7
EAEEEAQPESDGVEA	RP1L1	2011	Q8IWN7
ESDGVEAPEAEEEAQ	RP1L1	2051	Q8IWN7
EAEGEVQEAEGEAHP	RP1L1	2066	Q8IWN7
VQEAEGEAHPESEDV	RP1L1	2071	Q8IWN7
EAEGEAQPESEGVEA	RP1L1	2136	Q8IWN7
EGVEAQDAEGEAQPE	RP1L1	2146	Q8IWN7
EAQPESEGIEAQEAE	RP1L1	2156	Q8IWN7
SEGIEAQEAEEEAQP	RP1L1	2161	Q8IWN7
AQEAEEEAQPELEGV	RP1L1	2166	Q8IWN7
ELEGVEAPEAEGEAQ	RP1L1	2176	Q8IWN7
EEQEQDVEKEPEGGA	SMTNL1	251	A8MU46
DELIPFQDEGGEEQE	TCF7L1	36	Q9HCS4
NPVQVEVGEFDDGAE	SPARC	46	P09486
PSGDDVELIGEEEDV	UBE2O	626	Q9C0C9
AGPHAQEEDSQEEEE	TMEM51	106	Q9NW97
ECQVQVGAPEEEEEE	TERF1	46	P54274
EEGQDPDEIGIELEA	SAFB2	66	Q14151
NPGFEAEEEEEEVEG	PKD2	91	Q13563
GPENTAQAEGDEEEE	ZNFX1	801	Q9P2E3
DDDLQFEDPAEDIGT	ZBTB39	301	O15060
NSSVEDDDDVVFIEP	ZMYM2	51	Q9UBW7
EQEEQEEEGAGPAEV	ZBTB17	236	Q13105
PEELEEEGDVEEGYR	ERCC4	501	Q92889
NPQVEVLSEEEGEEE	USP34	2481	Q70CQ2
EDGAFETDEAPEDRI	WDR3	251	Q9UNX4
EIPEEGREVEEFSED	WBP11	341	Q9Y2W2
EENEQDGDLEGPVID	TUT7	191	Q5VYS8
NGAPEDEENFEEAIK	NAE1	256	Q13564
EQPVDVEVQDLEEFA	TUB	241	P50607
VEEDELFQVQAAPDE	TERF2	466	Q15554
PVVDSEEEAEEEFQK	TFIP11	206	Q9UBB9
EDENEEAPVARDEAG	WDR81	311	Q562E7
GEDAVEDDAEENPIV	SLC4A1AP	341	Q9BWU0
EEEEEEAAPDVIFQE	MYT1	301	Q01538