Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	perineuronal net	ACAN VCAN TNR	3.27e-05	10	138	3	GO:0072534
GeneOntologyCellularComponent	perisynaptic extracellular matrix	ACAN VCAN TNR	4.47e-05	11	138	3	GO:0098966
GeneOntologyCellularComponent	synapse-associated extracellular matrix	ACAN VCAN TNR	7.67e-05	13	138	3	GO:0099535
Domain	Ig-like_fold	FN1 HLA-B HLA-DMB HLA-H ESAM LINGO2 LRIT3 IGDCC4 PTPRD PTPRF AMIGO3 NFATC2 EPHA2 VCAN KIR2DL5A TNR CNTFR	9.09e-06	706	131	17	IPR013783
Domain	-	FN1 HLA-B HLA-DMB ESAM LINGO2 LRIT3 IGDCC4 PTPRD PTPRF AMIGO3 NFATC2 EPHA2 VCAN KIR2DL5A TNR CNTFR	1.66e-05	663	131	16	2.60.40.10
Domain	IG_LIKE	HLA-B HLA-DMB HLA-H ESAM LINGO2 LRIT3 IGDCC4 PTPRD PTPRF AMIGO3 VCAN KIR2DL5A CNTFR	4.22e-05	491	131	13	PS50835
Domain	FN3	FN1 LRIT3 IGDCC4 PTPRD PTPRF EPHA2 TNR CNTFR	4.88e-05	185	131	8	SM00060
Domain	Ig-like_dom	HLA-B HLA-DMB HLA-H ESAM LINGO2 LRIT3 IGDCC4 PTPRD PTPRF AMIGO3 VCAN KIR2DL5A CNTFR	5.40e-05	503	131	13	IPR007110
Domain	FN3	FN1 LRIT3 IGDCC4 PTPRD PTPRF EPHA2 TNR CNTFR	8.15e-05	199	131	8	PS50853
Domain	RanBD	RGPD8 ENAH RGPD5	9.16e-05	13	131	3	SM00160
Domain	Ran_bind_dom	RGPD8 ENAH RGPD5	9.16e-05	13	131	3	IPR000156
Domain	PTPc	PTPN3 PTPN14 PTPRD PTPRF	1.14e-04	36	131	4	SM00194
Domain	FN3_dom	FN1 LRIT3 IGDCC4 PTPRD PTPRF EPHA2 TNR CNTFR	1.15e-04	209	131	8	IPR003961
Domain	fn3	FN1 IGDCC4 PTPRD PTPRF EPHA2 TNR CNTFR	1.47e-04	162	131	7	PF00041
Domain	TYR_PHOSPHATASE_PTP	PTPN3 PTPN14 PTPRD PTPRF	1.57e-04	39	131	4	PS50055
Domain	PTPase_domain	PTPN3 PTPN14 PTPRD PTPRF	1.91e-04	41	131	4	IPR000242
Domain	Y_phosphatase	PTPN3 PTPN14 PTPRD PTPRF	1.91e-04	41	131	4	PF00102
Domain	IGc2	ESAM LINGO2 LRIT3 IGDCC4 PTPRD PTPRF AMIGO3 CNTFR	2.56e-04	235	131	8	SM00408
Domain	Ig_sub2	ESAM LINGO2 LRIT3 IGDCC4 PTPRD PTPRF AMIGO3 CNTFR	2.56e-04	235	131	8	IPR003598
Domain	FERM_CS	PTPN3 PTPN14 TLN1	6.13e-04	24	131	3	IPR019747
Domain	Prot-tyrosine_phosphatase-like	PTPN3 MTMR11 PTPN14 PTPRD PTPRF	6.64e-04	99	131	5	IPR029021
Domain	MHC_I_a_C	HLA-B HLA-H	7.19e-04	6	131	2	IPR010579
Domain	MHC_I_C	HLA-B HLA-H	7.19e-04	6	131	2	PF06623
Domain	IG	ESAM LINGO2 LRIT3 IGDCC4 PTPRD PTPRF AMIGO3 VCAN KIR2DL5A CNTFR	7.78e-04	421	131	10	SM00409
Domain	Ig_sub	ESAM LINGO2 LRIT3 IGDCC4 PTPRD PTPRF AMIGO3 VCAN KIR2DL5A CNTFR	7.78e-04	421	131	10	IPR003599
Domain	PTPc_motif	PTPN3 PTPN14 PTPRD PTPRF	7.81e-04	59	131	4	SM00404
Domain	Tyr_Pase_cat	PTPN3 PTPN14 PTPRD PTPRF	7.81e-04	59	131	4	IPR003595
Domain	PH_dom-like	RGPD8 PTPN3 MTMR11 PTPN14 RASAL3 TLN1 ENAH ARHGEF3 ARAP1 RGPD5	8.51e-04	426	131	10	IPR011993
Domain	FERM_N	PTPN3 PTPN14 TLN1	1.58e-03	33	131	3	IPR018979
Domain	FERM_N	PTPN3 PTPN14 TLN1	1.58e-03	33	131	3	PF09379
Domain	Tyr_Pase_AS	PTPN3 PTPN14 PTPRD PTPRF	1.73e-03	73	131	4	IPR016130
Domain	Ig_I-set	ESAM LINGO2 LRIT3 IGDCC4 PTPRD PTPRF	2.24e-03	190	131	6	IPR013098
Domain	I-set	ESAM LINGO2 LRIT3 IGDCC4 PTPRD PTPRF	2.24e-03	190	131	6	PF07679
Domain	Grip	RGPD8 RGPD5	2.58e-03	11	131	2	SM00755
Domain	GRIP	RGPD8 RGPD5	2.58e-03	11	131	2	PF01465
Domain	ARM-type_fold	USP34 GPRASP1 TTI2 INTS1 MROH5 SCYL1 CLASP2 BTAF1	2.72e-03	339	131	8	IPR016024
Domain	Ran_BP1	RGPD8 RGPD5	3.08e-03	12	131	2	PF00638
Domain	RANBD1	RGPD8 RGPD5	3.08e-03	12	131	2	PS50196
Domain	GRIP_dom	RGPD8 RGPD5	3.08e-03	12	131	2	IPR000237
Domain	GRIP	RGPD8 RGPD5	3.08e-03	12	131	2	PS50913
Domain	TYR_PHOSPHATASE_1	PTPN3 PTPN14 PTPRD PTPRF	3.15e-03	86	131	4	PS00383
Domain	TYR_PHOSPHATASE_dom	PTPN3 PTPN14 PTPRD PTPRF	3.28e-03	87	131	4	IPR000387
Domain	TYR_PHOSPHATASE_2	PTPN3 PTPN14 PTPRD PTPRF	3.28e-03	87	131	4	PS50056
Domain	Rho_GTPase_activation_prot	RASAL3 ARHGAP31 ARHGAP29 ARAP1	3.42e-03	88	131	4	IPR008936
Domain	PDZ	IL16 MAST2 PDLIM4 PTPN3 RHPN2	3.91e-03	148	131	5	SM00228
Domain	-	PTPN3 PTPN14 PTPRD PTPRF	4.01e-03	92	131	4	3.90.190.10
Domain	FERM_M	PTPN3 PTPN14 TLN1	4.11e-03	46	131	3	PF00373
Domain	-	IL16 MAST2 PDLIM4 PTPN3 RHPN2	4.14e-03	150	131	5	2.30.42.10
Domain	uDENN	DENND2A DENND4B	4.20e-03	14	131	2	SM00800
Domain	PDZ	IL16 MAST2 PDLIM4 PTPN3 RHPN2	4.25e-03	151	131	5	PS50106
Domain	PDZ	IL16 MAST2 PDLIM4 PTPN3 RHPN2	4.38e-03	152	131	5	IPR001478
Domain	HEAT	SCYL1 CLASP2 BTAF1	4.63e-03	48	131	3	PF02985
Domain	uDENN	DENND2A DENND4B	4.83e-03	15	131	2	PF03456
Domain	-	PTPN3 PTPN14 TLN1	4.91e-03	49	131	3	1.20.80.10
Domain	FERM_central	PTPN3 PTPN14 TLN1	4.91e-03	49	131	3	IPR019748
Domain	FERM_domain	PTPN3 PTPN14 TLN1	4.91e-03	49	131	3	IPR000299
Domain	FERM/acyl-CoA-bd_prot_3-hlx	PTPN3 PTPN14 TLN1	5.20e-03	50	131	3	IPR014352
Domain	FERM_1	PTPN3 PTPN14 TLN1	5.20e-03	50	131	3	PS00660
Domain	FERM_2	PTPN3 PTPN14 TLN1	5.20e-03	50	131	3	PS00661
Domain	FERM_3	PTPN3 PTPN14 TLN1	5.20e-03	50	131	3	PS50057
Domain	Band_41_domain	PTPN3 PTPN14 TLN1	5.20e-03	50	131	3	IPR019749
Domain	B41	PTPN3 PTPN14 TLN1	5.20e-03	50	131	3	SM00295
Domain	DENN	DENND2A DENND4B	5.49e-03	16	131	2	SM00799
Domain	DENN	DENND2A DENND4B	5.49e-03	16	131	2	PF02141
Domain	dDENN	DENND2A DENND4B	5.49e-03	16	131	2	PF03455
Domain	UDENN	DENND2A DENND4B	5.49e-03	16	131	2	PS50946
Domain	DDENN	DENND2A DENND4B	5.49e-03	16	131	2	PS50947
Domain	dDENN	DENND2A DENND4B	5.49e-03	16	131	2	SM00801
Domain	dDENN_dom	DENND2A DENND4B	5.49e-03	16	131	2	IPR005112
Domain	uDENN_dom	DENND2A DENND4B	5.49e-03	16	131	2	IPR005113
Domain	DENN	DENND2A DENND4B	5.49e-03	16	131	2	PS50211
Domain	DENN_dom	DENND2A DENND4B	5.49e-03	16	131	2	IPR001194
Domain	DUF1605	DHX38 DHX30	6.20e-03	17	131	2	IPR011709
Domain	OB_NTP_bind	DHX38 DHX30	6.20e-03	17	131	2	PF07717
Domain	-	RGPD8 PTPN3 PTPN14 RASAL3 TLN1 ENAH ARHGEF3 ARAP1	6.37e-03	391	131	8	2.30.29.30
Domain	C1-set	HLA-B HLA-DMB HLA-H	6.44e-03	54	131	3	PF07654
Domain	Lig_chan-Glu_bd	GRIN2C GRIN3A	6.94e-03	18	131	2	PF10613
Domain	Glu/Gly-bd	GRIN2C GRIN3A	6.94e-03	18	131	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIN2C GRIN3A	6.94e-03	18	131	2	SM00918
Domain	Iontro_rcpt	GRIN2C GRIN3A	6.94e-03	18	131	2	IPR001320
Domain	Iono_rcpt_met	GRIN2C GRIN3A	6.94e-03	18	131	2	IPR001508
Domain	HA2	DHX38 DHX30	6.94e-03	18	131	2	SM00847
Domain	HA2	DHX38 DHX30	6.94e-03	18	131	2	PF04408
Domain	Lig_chan	GRIN2C GRIN3A	6.94e-03	18	131	2	PF00060
Domain	Helicase-assoc_dom	DHX38 DHX30	6.94e-03	18	131	2	IPR007502
Domain	PBPe	GRIN2C GRIN3A	6.94e-03	18	131	2	SM00079
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP34 RNF223 RIN3 KMT2B PPRC1 WWP1 KSR2 INTS1 MED14 CLASP2 BTAF1 MAST2 DHX30 HIVEP3 PTPRF ADAMTS7 TLN1 HELZ2 LRRC56 ZC3H7B CHPF ARAP1	1.14e-09	1105	144	22	35748872
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	USP34 HLA-B DHX38 BTBD18 ZBTB22 SCYL1 BTAF1 MAST2 PRR14 MTMR11 EPHA2 ARHGAP29	2.03e-07	420	144	12	28065597
Pubmed	Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice.	FOXO1 TSC1 PCSK9	2.77e-07	4	144	3	22426206
Pubmed	Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla.	ADAMTS4 ACAN VCAN	2.77e-07	4	144	3	21584905
Pubmed	Protein tyrosine phosphatases expression during development of mouse superior colliculus.	NES PTPN14 PTPRD PTPRF	6.43e-07	17	144	4	19727691
Pubmed	The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding.	ACAN VCAN TNR	6.91e-07	5	144	3	11038354
Pubmed	Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule.	PTPRD PTPRF BSN	6.91e-07	5	144	3	22357843
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	FN1 OLFML2B SSC5D ADAMTS7 ACAN VCAN CPXM1 MSLN PCSK9	1.02e-06	248	144	9	24006456
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SCYL1 FAM186B KIAA1671 TMEM132C PRR14 RASAL3 ARHGAP31 TLN1 BSN NUP153 ARAP1	1.95e-06	430	144	11	35044719
Pubmed	Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors.	PTPRF ACAN VCAN	2.40e-06	7	144	3	21976490
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	ESAM LINGO2 LRIT3 IGDCC4 PTPRD PTPRF AMIGO3	5.38e-06	162	144	7	25826454
Pubmed	Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.	FN1 ACAN VCAN	1.12e-05	11	144	3	38750698
Pubmed	Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis.	ADAMTS4 ACAN CHPF	1.49e-05	12	144	3	36047655
Pubmed	Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5.	HLA-B ZBTB22 HLA-H MORC2	1.50e-05	36	144	4	15112104
Pubmed	ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain.	ADAMTS4 ADAMTS7	1.70e-05	2	144	2	15192113
Pubmed	Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B.	KIR2DL5B KIR2DL5A	1.70e-05	2	144	2	12185535
Pubmed	Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene.	KIR2DL5B KIR2DL5A	1.70e-05	2	144	2	11086080
Pubmed	Identification and characterization of versican/PG-M aggregates in cartilage.	ACAN VCAN	1.70e-05	2	144	2	16648631
Pubmed	Outcome of lumbar epidural steroid injection is predicted by assay of a complex of fibronectin and aggrecan from epidural lavage.	FN1 ACAN	1.70e-05	2	144	2	21224775
Pubmed	Cleavage of the carboxyl tail from the G3 domain of aggrecan but not versican and identification of the amino acids involved in the degradation.	ACAN VCAN	1.70e-05	2	144	2	11932252
Pubmed	Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments.	ADAMTS4 ACAN	1.70e-05	2	144	2	16188468
Pubmed	A heart segmental defect in the anterior-posterior axis of a transgenic mutant mouse.	FN1 VCAN	1.70e-05	2	144	2	9188753
Pubmed	The mouse gene Ptprf encoding the leukocyte common antigen-related molecule LAR: cloning, characterization, and chromosomal localization.	PTPRD PTPRF	1.70e-05	2	144	2	7665159
Pubmed	Association of KIR2DL5B gene with celiac disease supports the susceptibility locus on 19q13.4.	KIR2DL5B KIR2DL5A	1.70e-05	2	144	2	17215859
Pubmed	Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4).	ADAMTS4 ACAN	1.70e-05	2	144	2	10751421
Pubmed	FoxM1, a critical regulator of oxidative stress during oncogenesis.	FOXM1 FOXO1	1.70e-05	2	144	2	19696738
Pubmed	Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.	ADAMTS4 VCAN	1.70e-05	2	144	2	28955046
Pubmed	Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression.	FN1 VCAN	1.70e-05	2	144	2	23201264
Pubmed	Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis.	WWP1 PTPN14	1.70e-05	2	144	2	25814387
Pubmed	ADAMTS-4_v1 is a splice variant of ADAMTS-4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain.	ADAMTS4 ACAN	1.70e-05	2	144	2	23897278
Pubmed	ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.	FN1 ADAMTS4	1.70e-05	2	144	2	15161923
Pubmed	MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover.	ADAMTS4 ACAN	1.70e-05	2	144	2	22670872
Pubmed	Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.	FN1 ADAMTS4 ACAN VCAN	1.86e-05	38	144	4	29743679
Pubmed	Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth.	ADAMTS4 ACAN VCAN	1.93e-05	13	144	3	32909945
Pubmed	Muscleblind-like 1 is required for normal heart valve development in vivo.	FN1 ACAN VCAN	3.05e-05	15	144	3	26472242
Pubmed	Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation.	FN1 ACAN VCAN	3.05e-05	15	144	3	38018454
Pubmed	A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.	TSC1 CLASP2 MAST2 PTPN14 KIF1C	3.19e-05	87	144	5	17979178
Pubmed	Link protein has greater affinity for versican than aggrecan.	ACAN VCAN	5.09e-05	3	144	2	14724283
Pubmed	Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development.	ACAN VCAN	5.09e-05	3	144	2	19669783
Pubmed	Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan oligosaccharides.	ACAN VCAN	5.09e-05	3	144	2	15590670
Pubmed	LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.	PTPRD PTPRF	5.09e-05	3	144	2	31985401
Pubmed	Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.	PTPRD PTPRF	5.09e-05	3	144	2	20139422
Pubmed	FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis.	FOXO1 ACAN	5.09e-05	3	144	2	33199631
Pubmed	Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.	PTPRD PTPRF	5.09e-05	3	144	2	33656439
Pubmed	Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma.	ADAMTS4 VCAN	5.09e-05	3	144	2	28323982
Pubmed	The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety.	VCAN TNR	5.09e-05	3	144	2	9294172
Pubmed	Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican.	ACAN VCAN	5.09e-05	3	144	2	10400671
Pubmed	Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress.	ACAN TNR	5.09e-05	3	144	2	24625978
Pubmed	Distinct interaction of versican/PG-M with hyaluronan and link protein.	ACAN VCAN	5.09e-05	3	144	2	12888576
Pubmed	In situ hybridization and immunohistochemistry of versican, aggrecan and link protein, and histochemistry of hyaluronan in the developing mouse limb bud cartilage.	ACAN VCAN	5.09e-05	3	144	2	14620382
Pubmed	Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR and RPTPσ and Modulation of the Rho/ROCK Pathway.	PTPRD PTPRF	5.09e-05	3	144	2	25703008
Pubmed	Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and RPTPsigma in the mouse.	PTPRD PTPRF	5.09e-05	3	144	2	9784606
Pubmed	Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration.	PTPRF EPHA2	5.09e-05	3	144	2	23358419
Pubmed	Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection.	ACAN VCAN	5.09e-05	3	144	2	29515038
Pubmed	Immunolocalization of nestin, mesothelin and epithelial membrane antigen (EMA) in developing and adult serous membranes and mesotheliomas.	NES MSLN	5.09e-05	3	144	2	22113177
Pubmed	Expression of nestin, mesothelin and epithelial membrane antigen (EMA) in developing and adult human meninges and meningiomas.	NES MSLN	5.09e-05	3	144	2	20943257
Pubmed	Hyperglycemia affects neuronal differentiation and Nestin, FOXO1, and LMO3 mRNA expression of human Wharton's jelly mesenchymal stem cells of children from diabetic mothers.	FOXO1 NES	5.09e-05	3	144	2	36413852
Pubmed	Promoter variants of KIR2DL5 add to diversity and may impact gene expression.	KIR2DL5B KIR2DL5A	5.09e-05	3	144	2	18461314
Pubmed	Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.	TSC1 GRIN2C	5.09e-05	3	144	2	25081057
Pubmed	Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.	ADAMTS4 VCAN	5.09e-05	3	144	2	11278559
Pubmed	TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis.	FN1 TNR	5.09e-05	3	144	2	1696875
Pubmed	Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes.	HLA-B KIR2DL5B KIR2DL5A	5.42e-05	18	144	3	20200544
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	USP34 ATP10B MAST2 MICAL2 ARAP1	6.53e-05	101	144	5	9872452
Pubmed	A novel common variant in DCST2 is associated with length in early life and height in adulthood.	MTMR11 ACAN SPAG17	7.53e-05	20	144	3	25281659
Pubmed	BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response.	NES FN1 ACAN	7.53e-05	20	144	3	29483282
Pubmed	Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay.	HLA-B KIR2DL5B KIR2DL5A	7.53e-05	20	144	3	20193031
Pubmed	HLA and KIR frequencies in Sicilian Centenarians.	HLA-B KIR2DL5B KIR2DL5A	7.53e-05	20	144	3	20426625
Pubmed	Colinearity of novel genes in the class II regions of the MHC in mouse and human.	HLA-B HLA-DMB HLA-H	8.75e-05	21	144	3	1855816
Pubmed	Distribution of KIR genes in the population of unrelated individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3).	HLA-B KIR2DL5B KIR2DL5A	1.01e-04	22	144	3	20492596
Pubmed	Genome-wide association analysis identifies 20 loci that influence adult height.	ACAN UQCC1 SPAG17	1.01e-04	22	144	3	18391952
Pubmed	Characterisation of the expression of NMDA receptors in human astrocytes.	GRIN2C GRIN3A	1.02e-04	4	144	2	21152063
Pubmed	Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.	FOXO1 TSC1	1.02e-04	4	144	2	17077083
Pubmed	ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.	ADAMTS4 ACAN	1.02e-04	4	144	2	14701864
Pubmed	Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections.	KIR2DL5B KIR2DL5A	1.02e-04	4	144	2	22652695
Pubmed	The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1.	PTPRD PTPRF	1.02e-04	4	144	2	8524829
Pubmed	Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.	WWP1 HIVEP3	1.02e-04	4	144	2	16728642
Pubmed	KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains.	KIR2DL5B KIR2DL5A	1.02e-04	4	144	2	10820258
Pubmed	Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associations.	FN1 VCAN	1.02e-04	4	144	2	9676579
Pubmed	Nef-arious goings-on at the Golgi.	HLA-B AP1M1	1.02e-04	4	144	2	22767237
Pubmed	NFAT restricts osteochondroma formation from entheseal progenitors.	NFATC2 ACAN	1.02e-04	4	144	2	27158674
Pubmed	ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.	ADAMTS4 ACAN	1.02e-04	4	144	2	11854269
Pubmed	FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis.	FOXO1 ACAN	1.02e-04	4	144	2	31980519
Pubmed	Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef.	HLA-B AP1M1	1.02e-04	4	144	2	22705789
Pubmed	Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin.	FN1 TLN1	1.02e-04	4	144	2	12867986
Pubmed	The neuronal extracellular matrix restricts distribution and internalization of aggregated Tau-protein.	ACAN TNR	1.02e-04	4	144	2	26621125
Pubmed	Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.	RGPD8 RGPD5	1.02e-04	4	144	2	9480752
Pubmed	FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration.	FOXO1 ACAN	1.02e-04	4	144	2	29963746
Pubmed	Lecticans: organizers of the brain extracellular matrix.	ACAN VCAN	1.02e-04	4	144	2	10766023
Pubmed	Proteolytic cleavage of versican during limb joint development.	ADAMTS4 VCAN	1.02e-04	4	144	2	20101710
Pubmed	Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5.	KIR2DL5B KIR2DL5A	1.02e-04	4	144	2	18498296
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	FN1 ACAN VCAN	1.69e-04	26	144	3	34189436
Pubmed	Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.	PTPRD PTPRF KIR2DL5A	1.69e-04	26	144	3	36178190
Pubmed	Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.	GRIN2C PLA2G4F GRIN3A	1.69e-04	26	144	3	9745929
Pubmed	Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) alpha and membrane-distal protein-tyrosine phosphatase domains of various RPTPs.	PTPRD PTPRF	1.69e-04	5	144	2	10777529
Pubmed	Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes.	ADAMTS4 ACAN	1.69e-04	5	144	2	28081267
Pubmed	FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis.	FOXO1 TSC1	1.69e-04	5	144	2	21075312
Pubmed	Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1.	FN1 ACAN	1.69e-04	5	144	2	16061471
Pubmed	IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ.	PTPRD BSN	1.69e-04	5	144	2	21940441
Pubmed	Disruption of the talin gene arrests mouse development at the gastrulation stage.	FN1 TLN1	1.69e-04	5	144	2	11084655
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	FOXM1 FOXO1 USP34 RGPD8 DHX38 DTL TSC1 KIAA1671 PTPN14 BSN	1.79e-04	588	144	10	38580884
GeneFamily	Fibronectin type III domain containing	FN1 IGDCC4 PTPRD PTPRF EPHA2 TNR CNTFR	3.62e-05	160	103	7	555
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	ACAN VCAN	1.91e-04	4	103	2	574
GeneFamily	Glutamate ionotropic receptor NMDA type subunits	GRIN2C GRIN3A	6.63e-04	7	103	2	1201
GeneFamily	PDZ domain containing	IL16 MAST2 PDLIM4 PTPN3 RHPN2	1.78e-03	152	103	5	1220
GeneFamily	Histocompatibility complex\|C1-set domain containing	HLA-B HLA-DMB HLA-H	2.01e-03	44	103	3	588
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	LINGO2 LRIT3 IGDCC4 PTPRD PTPRF	2.28e-03	161	103	5	593
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PTPN3 PTPN14 TLN1	2.90e-03	50	103	3	1293
GeneFamily	DEAH-box helicases	DHX38 DHX30	3.66e-03	16	103	2	500
GeneFamily	Protein tyrosine phosphatases, non-receptor type	PTPN3 PTPN14	4.63e-03	18	103	2	812
GeneFamily	WD repeat domain containing\|DDB1 and CUL4 associated factors	DTL PHIP	4.63e-03	18	103	2	498
GeneFamily	CD molecules\|Killer cell immunoglobulin like receptors	KIR2DL5B KIR2DL5A	4.63e-03	18	103	2	620
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS4 ADAMTS7	5.16e-03	19	103	2	50
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRD PTPRF	6.29e-03	21	103	2	813
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	TEX13A NUP153	6.29e-03	21	103	2	89
Coexpression	ZENG_GU_ICB_CONTROL_METAGENE_3_PRECICTIVE_ICB_RESPONSE	FN1 HLA-B HLA-H ZNF831 MTMR11 DENND4B PVRIG TXN2 MSLN	2.51e-06	211	143	9	MM17081
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES CPAMD8 FN1 ESAM PDLIM4 PTPN14 ARHGAP31 CLEC14A ARHGAP29	1.56e-08	198	142	9	58508a8df2714d769f137794c29441a7bd38b350
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES FN1 ESAM PDLIM4 PTPN14 ARHGAP31 CLEC14A ARHGAP29	1.88e-07	191	142	8	adb2e3efcad02889d8229325080da5e7830fd3ae
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NES ESAM TNFRSF4 KIAA1671 CLEC14A ARHGAP29 ARHGEF3 TNR	1.96e-07	192	142	8	7197e401e563441ab94815f7619e032ebef9e586
ToppCell	5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES FN1 ESAM PDLIM4 PTPN14 ARHGAP31 CLEC14A ARHGAP29	2.38e-07	197	142	8	61b1b10a017cbeb17f8529fcae66cba77ee2f115
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuroepithelial-Proteoglycan-expressing_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	FN1 OLFML2B IGDCC4 TMEM132C MTMR11 ARHGAP29 MSLN PCSK9	2.67e-07	200	142	8	07d2133c85e0a4eb8bef653ee15ecd0f1b2bbd44
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuroepithelial\|10w / Sample Type, Dataset, Time_group, and Cell type.	FN1 OLFML2B IGDCC4 TMEM132C MTMR11 ARHGAP29 MSLN PCSK9	2.67e-07	200	142	8	ff0b2675c68e9fc1fa16b3276431f199f3642eac
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Fibroblasts-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KSR2 ZBTB22 GRIN2C HIVEP3 OTUD7A CNTFR PCSK9	7.70e-07	158	142	7	7f5426585d0d299d2b48e5fcb349950feffdef33
ToppCell	P07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FN1 HIVEP3 PTPRD VCAN ENAH CPXM1 ARAP1	8.74e-07	161	142	7	b19f82dd98a3064581793711bb70373f18abecd9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LVRN FN1 DTL TMEM132C SSC5D MICAL2 TNR	1.03e-06	165	142	7	e2aebb2fe197151e019371b8960f76f0c2386f08
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LVRN FN1 DTL TMEM132C SSC5D MICAL2 TNR	1.03e-06	165	142	7	b087771499aeb31cc4a338d2d0a9392a4ec1ac45
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LVRN FN1 DTL TMEM132C SSC5D MICAL2 TNR	1.03e-06	165	142	7	d8f8b088fd28a6b9dbd6b51bcaee42000e963321
ToppCell	Monocytes-IFN-activated_Monocytes\|Monocytes / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	FN1 HLA-B NLGN4Y FHAD1 VCAN HELZ2 TNNT1	1.59e-06	176	142	7	6a4b403ee3e4dc4f23fbd7a154011e41fd429a9e
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DENND2A BEST3 ATP10B TMEM132C ARHGAP31 VCAN TNR	1.98e-06	182	142	7	8a8b08ac4bb3cba3541dbe234e088703842285b9
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HLA-B BEST3 ATP10B TMEM132C ARHGAP31 VCAN TNR	1.98e-06	182	142	7	a05e5978ef5f7fac7eeb2ba1c0103ea90d5e9136
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DENND2A BEST3 ATP10B TMEM132C ARHGAP31 VCAN TNR	1.98e-06	182	142	7	e36766309c4d96a90d213ce37d3acef1029a3fdc
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HLA-B BEST3 ATP10B TMEM132C ARHGAP31 VCAN TNR	1.98e-06	182	142	7	831b5ce46b41efe01c4db6016c2f43148611373d
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTS4 OLFML2B IL17D IGDCC4 CPXM1 GRIN3A CNTFR	2.21e-06	185	142	7	1b990e3089772be2b38c6d7ea0d1bf22461ae3ea
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CA12 DENND2A NLGN4Y DNER LINGO2 HIVEP3 SORCS3	2.37e-06	187	142	7	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNER IL17D ACAN VCAN CPXM1 GRIN3A TNR	2.46e-06	188	142	7	7471c194276161422326647f09022e94f3d1640c
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNER IL17D ACAN VCAN CPXM1 GRIN3A TNR	2.46e-06	188	142	7	053c251d3ddbeb866f34565aefca4535517b4387
ToppCell	LAM-Endothelial-VasEndo-1\|LAM / Condition, Lineage and Cell class	NES HLA-B ESAM TNFRSF4 CLEC14A ARHGAP29 TNR	2.55e-06	189	142	7	454e64b1ee93edebbc1576fbf7c3a6db332fa927
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND2A IGDCC4 TMEM132C HIVEP3 PTPRD VCAN SORCS3	2.64e-06	190	142	7	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 OLFML2B TMEM132C PTPRF VCAN CHPF ARAP1	2.73e-06	191	142	7	9214655dca96d766737c9f30b624d7fe7050342e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DENND2A NLGN4Y HIVEP3 PTPN3 PTPN14 ARHGAP29 ARHGEF3	2.73e-06	191	142	7	5717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DENND2A NLGN4Y HIVEP3 PTPN3 PTPN14 ARHGAP29 ARHGEF3	2.73e-06	191	142	7	9032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DTL ESAM KIAA1671 ARHGAP31 CLEC14A ARHGAP29 ARHGEF3	2.82e-06	192	142	7	c07d7b40b2aa4eb27ac85801c014a656e2fd01dc
ToppCell	LPS-IL1RA+antiTNF-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DTL ESAM KIAA1671 ARHGAP31 CLEC14A ARHGAP29 ARHGEF3	2.82e-06	192	142	7	04f5a2e3dd6beff027b89d66eefdd92036e041af
ToppCell	LPS-antiTNF-Endothelial-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DTL ESAM KIAA1671 ARHGAP31 CLEC14A ARHGAP29 ARHGEF3	2.92e-06	193	142	7	02f633b016ab19bfa65bfd0cf32f000549a62148
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DTL ESAM KIAA1671 ARHGAP31 CLEC14A ARHGAP29 ARHGEF3	2.92e-06	193	142	7	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	LPS-antiTNF-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DTL ESAM KIAA1671 ARHGAP31 CLEC14A ARHGAP29 ARHGEF3	2.92e-06	193	142	7	5122b1ffba42de190061be34ecdc6176f84e56a3
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NES HLA-B ESAM TNFRSF4 ANKRD33 CLEC14A ARHGAP29	2.92e-06	193	142	7	aaf681f16f310168e4719464814a1fc0a2f8431a
ToppCell	LPS-IL1RA-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DTL ESAM KIAA1671 ARHGAP31 CLEC14A ARHGAP29 ARHGEF3	3.02e-06	194	142	7	43f92b0533e26633dc94cce554045d641ef8fd76
ToppCell	LPS-IL1RA-Endothelial-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DTL ESAM KIAA1671 ARHGAP31 CLEC14A ARHGAP29 ARHGEF3	3.02e-06	194	142	7	1d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_capillary_(2)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	HLA-B ESAM TNFRSF4 KIAA1671 CLEC14A ARHGAP29 ARHGEF3	3.02e-06	194	142	7	3c31ac44e8cf4eca3ba7b8bfc05ad3e96a970956
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NES HLA-B ESAM TNFRSF4 CLEC14A ARHGAP29 TNR	3.13e-06	195	142	7	e8992c549dad9a88d2b8d01039a8d02a950b29b4
ToppCell	11.5-Distal-Endothelial\|Distal / Age, Tissue, Lineage and Cell class	FOXO1 HLA-B ESAM TNFRSF4 KIAA1671 CLEC14A ARHGAP29	3.13e-06	195	142	7	efdede0f476883ffddd247fa7bc6449e7932613e
ToppCell	11.5-Distal-Endothelial-Endothelial\|Distal / Age, Tissue, Lineage and Cell class	FOXO1 HLA-B ESAM TNFRSF4 KIAA1671 CLEC14A ARHGAP29	3.13e-06	195	142	7	1e9b52b201ab6c78f536609e2afe1d680c71a6e7
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BEST3 ATP10B TMEM132C ACAN VCAN SORCS3 TNR	3.24e-06	196	142	7	f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BEST3 ATP10B TMEM132C ACAN VCAN SORCS3 TNR	3.24e-06	196	142	7	671c380b58d7f634b4fbec38c357d357ea4f3535
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-osteoblast_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	NES FN1 OLFML2B ACAN ENAH OTUD7A CHPF	3.35e-06	197	142	7	2f72fd9a5b6d62c24a95ed2246194ea7458c0f12
ToppCell	5'-Adult-Distal_Rectal-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES FN1 ESAM PDLIM4 PTPN14 CLEC14A ARHGAP29	3.46e-06	198	142	7	8d6b0b9da7c1e64155cbcbb04ad38d129a29030c
ToppCell	5'-Adult-Appendix-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS4 ESAM PDLIM4 PTPN14 ARHGAP31 CLEC14A ARHGAP29	3.46e-06	198	142	7	90e85fe7a0ab376a41666dfff6c0e95b7f1c9475
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES CPAMD8 FN1 ESAM PDLIM4 PTPN14 CLEC14A	3.46e-06	198	142	7	8a55589b9244283e4b0b423a4a6d6202e8e0fec9
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES FN1 ESAM PDLIM4 PTPN14 CLEC14A ARHGAP29	3.46e-06	198	142	7	d1f54ed3ef5e05ebda7da999e172d168dc6802cd
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NES HLA-B ESAM TNFRSF4 CLEC14A ARHGAP29 TNR	3.46e-06	198	142	7	9ecf944984aade1bf902e3a92ea4d46a3696822f
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 OLFML2B SSC5D NFATC2 ACAN CHPF CNTFR	3.46e-06	198	142	7	524305c5d7b1d53e86ec0af775efefa3e0955e47
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	FN1 TMEM132C PTPRD VCAN ENAH SORCS3 CNTFR	3.58e-06	199	142	7	c2c42ecf20d1924edc2f899c01dfa5fcf3c210b9
ToppCell	10x3'2.3-week_14-16-Endothelial-stroma-tip_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	NES FN1 ADAMTS4 ESAM KIAA1671 CLEC14A ARHGAP29	3.58e-06	199	142	7	1c69395c9305b6ecb0a826d46c8e8ec95795ad6d
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DENND2A IGDCC4 TMEM132C HIVEP3 PTPRD VCAN SORCS3	3.58e-06	199	142	7	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	NES FN1 OLFML2B IGDCC4 ACAN ENAH CHPF	3.58e-06	199	142	7	bf138cc692df727e087d140c014149ee5da00d9d
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	NES FN1 OLFML2B IGDCC4 ACAN ENAH CHPF	3.58e-06	199	142	7	d65ee89d5c7e8ed693d58e6a6de09565840e11c5
ToppCell	Control_saline-Mesenchymal_fibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	FN1 TMEM132C PTPRD VCAN ENAH SORCS3 CNTFR	3.70e-06	200	142	7	64ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCell	Bronchial-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FOXO1 CPAMD8 IL16 FN1 DNER ACAN CNTFR	3.70e-06	200	142	7	b7b9441fa7ab0d43741a2ebd5ec1a48d537c6d47
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NES HLA-B ESAM TNFRSF4 CLEC14A ARHGAP29 TNR	3.70e-06	200	142	7	16a70cc07dcfb4eba4385b712f27010c6629ff67
ToppCell	Bronchial-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FOXO1 CPAMD8 IL16 FN1 DNER ACAN CNTFR	3.70e-06	200	142	7	7c673ad0ea503ebd196579684d25d5f9e6a41030
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts\|Control_saline / Treatment groups by lineage, cell group, cell type	FN1 TMEM132C PTPRD VCAN ENAH SORCS3 CNTFR	3.70e-06	200	142	7	a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A IL16 ADAMTS4 IGDCC4 TMEM132C VCAN CNTFR	3.70e-06	200	142	7	74e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	CPAMD8 FN1 TMEM132C PTPRD VCAN SORCS3 CNTFR	3.70e-06	200	142	7	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RUSC1 MON1A MTMR11 ADAMTS7 CHPF MTX1	1.22e-05	159	142	6	c8b42ebc25ebcc450832096fbffaa5c5f5fe88e7
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RUSC1 MON1A MTMR11 ADAMTS7 CHPF MTX1	1.22e-05	159	142	6	9f6607e395bcca9cb1c83199bdbbaaa62a93938d
ToppCell	10x3'2.3-week_12-13-Myeloid_DC-DC-DC3\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	HLA-B HLA-DMB MTMR11 ANKRD33 VCAN MSLN	1.31e-05	161	142	6	39030380e04f57f8e7de231577ec3177e1b6490d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DENND2A NLGN4Y DNER TMEM132C HIVEP3 SORCS3	1.31e-05	161	142	6	4bb7bae54ba3bdf46b525c01f5ad3db8e49819cb
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	ADAMTS4 OLFML2B IGDCC4 SSC5D VCAN CPXM1	1.67e-05	168	142	6	aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCell	droplet-Skin-nan-18m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NES TMEM132C SSC5D PTPRD VCAN CPXM1	1.78e-05	170	142	6	10e0912dd0beab5d0bbe2bd49e477b5962687925
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FOXM1 FN1 DTL MICAL2 ACAN VCAN	1.84e-05	171	142	6	b0373ed8283ee1792b6a490bff93906546978593
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FOXM1 FN1 DTL MICAL2 ACAN VCAN	1.84e-05	171	142	6	b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NLGN4Y DNER PPM1J IGDCC4 RHPN2 SORCS3	1.90e-05	172	142	6	eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NLGN4Y DNER PPM1J IGDCC4 RHPN2 SORCS3	1.90e-05	172	142	6	0c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCell	343B-Fibroblasts-Fibroblast-H\|343B / Donor, Lineage, Cell class and subclass (all cells)	ADAMTS4 IGDCC4 SSC5D PRR19 CPXM1 CNTFR	2.03e-05	174	142	6	507a33e58f62e2b72f0bcc743e84dbd0bf705a15
ToppCell	343B-Fibroblasts-Fibroblast-H-\|343B / Donor, Lineage, Cell class and subclass (all cells)	ADAMTS4 IGDCC4 SSC5D PRR19 CPXM1 CNTFR	2.03e-05	174	142	6	2627c3983009839fedbc5e3f628739dc026447f4
ToppCell	RSV-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	IL16 HLA-B ADAMTS4 KIAA1671 HELZ2 TOR1AIP1	2.10e-05	175	142	6	ff3a27f512a3a710ebc863b7b75cce8167d5440b
ToppCell	RSV-Healthy-1\|RSV / Virus stimulation, Condition and Cluster	IL16 HLA-B ADAMTS4 KIAA1671 HELZ2 TOR1AIP1	2.10e-05	175	142	6	ca52b99b03535a5b3a2751d6981708dc5b255b91
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FN1 DTL HIVEP3 PTPRD VCAN CPXM1	2.17e-05	176	142	6	cb8fd56a4f935cdda19d7ab43382cdda7c307667
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	FN1 ADAMTS4 OLFML2B SSC5D ARHGAP31 VCAN	2.31e-05	178	142	6	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGDCC4 TMEM132C HIVEP3 PTPRD ENAH SORCS3	2.46e-05	180	142	6	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS4 ESAM TNFRSF4 ADAMTS7 CLEC14A ARHGAP29	2.46e-05	180	142	6	efc4c5a4dea456527526bbfd88cf70d803893671
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ESAM LINGO2 BRWD3 PTPN14 RHPN2 CLEC14A	2.46e-05	180	142	6	2d608b9394d28d19cfc85c6ac94003d5177c8a92
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ESAM LINGO2 BRWD3 PTPN14 RHPN2 CLEC14A	2.46e-05	180	142	6	baa5825e6ce23a98d9c21d024a4b0ab8ba353d0c
ToppCell	368C-Endothelial_cells-Endothelial-E\|368C / Donor, Lineage, Cell class and subclass (all cells)	RGPD8 DTL ESAM PTPN14 CLEC14A ARHGAP29	2.46e-05	180	142	6	8ab16a0b9053bffc07b569a4f9e71749f56dde7e
ToppCell	368C-Endothelial_cells-Endothelial-E-\|368C / Donor, Lineage, Cell class and subclass (all cells)	RGPD8 DTL ESAM PTPN14 CLEC14A ARHGAP29	2.46e-05	180	142	6	394cd465b88429b70eebb2957480dffcbc51cfe7
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ESAM LINGO2 BRWD3 PTPN14 RHPN2 CLEC14A	2.46e-05	180	142	6	0f9b27054358c4737eed06c8ea01987cccc3cb55
ToppCell	COPD-Endothelial-VE_Capillary_A\|World / Disease state, Lineage and Cell class	NES CPAMD8 ESAM TNFRSF4 CLEC14A ARHGAP29	2.54e-05	181	142	6	61608123959483ff60f07d8467996853c4371b6a
ToppCell	facs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND2A FN1 DTL TNFRSF4 SSC5D VCAN	2.54e-05	181	142	6	c7f5aedcb74c21fb587a95a16d700e2a38a380ee
ToppCell	facs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND2A FN1 DTL TNFRSF4 SSC5D VCAN	2.54e-05	181	142	6	0ec9621a078d004bbd25a587757d24b5cf162959
ToppCell	10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	NES ESAM CLEC14A EPHA2 ARHGAP29 TNR	2.62e-05	182	142	6	997d37ca2af661c92a56add888762724dfccc890
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BEST3 ATP10B TMEM132C ARHGAP31 VCAN TNR	2.62e-05	182	142	6	3cc61f5f7ad4a81eba3daf65e122880b5af3adc0
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BEST3 ATP10B TMEM132C ARHGAP31 VCAN TNR	2.62e-05	182	142	6	5d909e4b5f662905bf1be9c686bbddc3e87d2be9
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-Treg\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL16 HLA-B ZNF831 TNFRSF4 HIVEP3 RASAL3	2.70e-05	183	142	6	450c30d2e389fcb17825394c27f9ccc4f33022e3
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES DTL ESAM TNFRSF4 CLEC14A ARHGAP29	2.78e-05	184	142	6	fa38d6a8709f520a027ad7e3ff783c84187ec467
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	FOXO1 PTPRD NFATC2 MICAL2 VCAN ARHGEF3	2.78e-05	184	142	6	d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCell	(2)_5-FU-(4)_COL2.3+_osteoblasts\|World / Stress and Cell class	FN1 OLFML2B IGDCC4 PDLIM4 MICAL2 CPXM1	2.78e-05	184	142	6	684d05340a3dfb8aa08b881516a37f9627a10448
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BEST3 ATP10B TMEM132C ARHGAP31 VCAN TNR	2.87e-05	185	142	6	2e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BEST3 ATP10B TMEM132C ARHGAP31 VCAN TNR	2.87e-05	185	142	6	7aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BEST3 ATP10B TMEM132C ARHGAP31 VCAN TNR	2.87e-05	185	142	6	fba2dc46cd98ab9c78e788959c2121aa10d148b2
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BEST3 ATP10B TMEM132C ARHGAP31 VCAN TNR	2.87e-05	185	142	6	efc5d564f8793c751ba640aef60f761e4b081d3f
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXO1 PTOV1 PTPN14 PTPRF TLN1 KIF1C	2.96e-05	186	142	6	bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCell	10x3'2.3-week_12-13-Mesenchymal_adipo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	OLFML2B IL17D IGDCC4 TMEM132C ACAN ENAH	3.05e-05	187	142	6	f1d0fc625e0e7881b3f290742fd7148d995eb71e
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES FN1 PTPN14 NFATC2 ARHGAP31 CLEC14A	3.05e-05	187	142	6	37d8ee5c8bd6324749e5a2adef1d0482c75da80c
ToppCell	3'-Adult-Appendix-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES FN1 PTPN14 NFATC2 ARHGAP31 CLEC14A	3.05e-05	187	142	6	ec98d5e480b08854dfd0ba6b1dc6610455f90640
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BEST3 ATP10B TMEM132C VCAN CPXM1 TNR	3.05e-05	187	142	6	5b7a1edee602e55d3400dc17dbb6b8aaa26defc0
Disease	protein O-glucosyltransferase 1 measurement	ARHGAP31 ARHGEF3	6.31e-05	3	136	2	EFO_0801955
Disease	anterior segment dysgenesis (implicated_via_orthology)	CPAMD8 TSC1	6.31e-05	3	136	2	DOID:0060648 (implicated_via_orthology)
Disease	parental longevity	ZNF704 HLA-B KSR2 ZBTB22 FAM186B PTPRD PROX2 OTUD7A BSN PHIP	1.02e-04	494	136	10	EFO_0007796
Disease	nuclear protein MDM1 measurement	ZFAND2B ARHGEF3	1.26e-04	4	136	2	EFO_0802822
Disease	regulator of microtubule dynamics protein 1 measurement	WWP1 ARHGEF3	2.09e-04	5	136	2	EFO_0801998
Disease	splicing factor 3B subunit 4 measurement	MTMR11 ARHGEF3	2.09e-04	5	136	2	EFO_0803100
Disease	Antihypertensive use measurement	SEM1 ZNF831 NFATC2 SORCS3 ARHGEF3 PHIP CNTFR	2.37e-04	265	136	7	EFO_0009927
Disease	angina pectoris	HLA-B DHX38 BRWD3 ADAMTS7 PCSK9	2.91e-04	125	136	5	EFO_0003913
Disease	Calcium channel blocker use measurement	USP34 HLA-B ZNF831 NFATC2 SORCS3 MTX1	4.75e-04	213	136	6	EFO_0009930
Disease	attention function measurement	KSR2 ZNF831 PTPN3 PTPRD ARHGEF3	6.30e-04	148	136	5	EFO_0007636
Disease	basophil count, eosinophil count	FOXO1 RIN3 HLA-B HIVEP3 NFATC2 ZC3H7B	9.06e-04	241	136	6	EFO_0004842, EFO_0005090
Disease	non-receptor tyrosine-protein kinase TYK2 measurement	HLA-B ARHGEF3	9.26e-04	10	136	2	EFO_0008251
Disease	degenerative disc disease (biomarker_via_orthology)	ADAMTS4 ACAN	1.13e-03	11	136	2	DOID:90 (biomarker_via_orthology)
Disease	endometriosis	RIN3 FN1 KSR2 MROH5 PTPN14 BSN	1.14e-03	252	136	6	EFO_0001065
Disease	gastroesophageal reflux disease	HLA-B MON1A VCAN SORCS3	1.25e-03	101	136	4	EFO_0003948
Disease	visceral adipose tissue measurement	HLA-B WWP1 DNER LINGO2 MON1A MAST2 HIVEP3 ARHGEF3	1.80e-03	481	136	8	EFO_0004765
Disease	pulse pressure measurement	USP34 RIN3 FN1 HLA-B TTI2 H1-7 ZNF831 MAST2 FAM186B HIVEP3 PTPRD NFATC2 CPXM1 SORCS3 UQCC1	1.94e-03	1392	136	15	EFO_0005763
Disease	lung disease severity measurement	TSC1 CLASP2 KIAA1671 TMEM132C	2.21e-03	118	136	4	EFO_0007744
Disease	mean arterial pressure	ZNF831 HIVEP3 PTPRD NFATC2 PROX2 ARHGEF3 MTX1 PHIP	2.26e-03	499	136	8	EFO_0006340
Disease	ferritin measurement	FN1 DHX38 DACT2 PTPRD	2.28e-03	119	136	4	EFO_0004459
Disease	urate measurement, bone density	SEM1 DNER CLASP2 GRIN2C PTPRD HELZ2 DMBT1 NUP153 JPH3	2.35e-03	619	136	9	EFO_0003923, EFO_0004531
Disease	endoplasmic reticulum resident protein 29 measurement	HLA-B ARHGEF3	2.43e-03	16	136	2	EFO_0020346
Disease	breast carcinoma	ZNF704 RIN3 PPRC1 HLA-H MAST2 HIVEP3 MTMR11 PTPRD SORCS3 ZC3H7B SPAG17 PHIP	2.72e-03	1019	136	12	EFO_0000305
Disease	RS-warfarin measurement	CA12 TMEM132C PTPN3 PHIP	2.96e-03	128	136	4	EFO_0803325
Disease	pulmonary surfactant-associated protein d measurement	HLA-B ARHGEF3	3.07e-03	18	136	2	EFO_0020693
Disease	lymphocyte count	IL16 FN1 HLA-B DNER ZNF831 PDLIM4 PRR14 RASAL3 NFATC2 ARHGAP31 TLN1 AP1M1 ARHGEF3 DMBT1 ZC3H7B	3.14e-03	1464	136	15	EFO_0004587
Disease	serum IgE measurement	HLA-H TMEM132C TLN1	3.25e-03	64	136	3	EFO_0004579
Disease	susceptibility to cold sores measurement	HLA-B HLA-H MICAL2	3.40e-03	65	136	3	EFO_0008402
Disease	comparative body size at age 10, self-reported	HLA-B KSR2 LINGO2 ZDHHC1 MTMR11 ACAN ZC3H7B	3.42e-03	420	136	7	EFO_0009819
Disease	exercise test	LRIT3 PTPRD	3.79e-03	20	136	2	EFO_0004328
Disease	cerebellum white matter volume change measurement, age at assessment	LINGO2 ADAMTS7	3.79e-03	20	136	2	EFO_0008007, EFO_0021498
Disease	myeloid white cell count	USP34 RIN3 FN1 HLA-B MAST2 HIVEP3 MICAL2 ENAH ARHGEF3 SPAG17 TNR	4.16e-03	937	136	11	EFO_0007988
Disease	gestational age, birth measurement	OLFML2B PTPRD	4.18e-03	21	136	2	EFO_0005112, EFO_0006921
Disease	proprotein convertase subtilisin/kexin type 9 measurement	KSR2 PCSK9	4.59e-03	22	136	2	EFO_0009312
Disease	ubiquitin carboxyl-terminal hydrolase 25 measurement	HLA-B ARHGEF3	4.59e-03	22	136	2	EFO_0021881

Protein segments in the cluster

Peptide	Gene	Start	Entry
LERWSPSVSRSTSPP	nan	111	A8MUN3
LDVPSRNPPRASPTW	BEST3	436	Q8N1M1
SPPAQRPWSSSGVQR	CCDC187	566	A0A096LP49
ILAPRPWSRNAAPSS	ARHGEF3	81	Q9NR81
VPWLSPQTSERPTLS	VCAN	2991	P13611
APRPPATVTNAVSWR	AP1M1	146	Q9BXS5
TRTPWAARELTPTPD	CPXM1	511	Q96SM3
QWILDTIPRRSPFVP	BRWD3	926	Q6RI45
PVTGTSIRRLTWPSL	FAM186B	636	Q8IYM0
IRNWVTRTPSSSPPI	DTL	501	Q9NZJ0
CRRWPQTPSPLQELS	AMIGO3	416	Q86WK7
RELAVTTTPSNWRPP	LVRN	76	Q6Q4G3
PPTSWRQLNPESIRP	DHX30	161	Q7L2E3
IQSWRSRQRPAPVPE	ATP10B	1346	O94823
DSQSQLPPPWRDRTN	ADAMTS7	1201	Q9UKP4
SSPNPSDIRVAWLPL	IGDCC4	536	Q8TDY8
DSASLPRKPSVPWQR	RASAL3	856	Q86YV0
WLQPRDSTSPRPQVP	ANKRD33	386	Q7Z3H0
SPETPPRWTEDRNSL	RGPD5	796	Q99666
SPETPPRWTEDRNSL	RGPD8	796	O14715
KSLPSRSPPITPNWR	PTPN3	366	P26045
PEPLTLRWEPSSQPT	HLA-H	291	P01893
RSPIEWSAPSNPLVI	KIR2DL5A	101	Q8N109
RNSAPESILLVPPTW	NFATC2	361	Q13469
ERPLQQVSPVASVPW	KIAA1671	1481	Q9BY89
SRPARSLQPQVTWQP	IL17REL	316	Q6ZVW7
PRWQSSSPRPVALAL	INTS1	1366	Q8N201
RARTLSVSPNLWVPP	NUDT17	111	P0C025
VRVPDTLTFLRNTPW	MTMR11	466	A4FU01
SFTPSSRAPTAWVRP	LINC02693	31	A8MQB3
PRIWPQVTPTGRSAS	KCNJ5-AS1	36	Q8TAV5
EPTPWIRTHLSQSPR	KSR2	186	Q6VAB6
NTLSVPRWSPQIPRR	KSR2	391	Q6VAB6
EVPSRASPPVWHAVR	EZHIP	391	Q86X51
TPHRPSTPRLVWQES	BSN	1536	Q9UPA5
TTPPCNPTVLWTVFR	CA12	226	O43570
RSPIEWSAPSNPLVI	KIR2DL5B	101	Q8NHK3
AQSIPWNLERITPPR	PCSK9	151	Q8NBP7
TARVTLTSPWPRPLP	GHDC	151	Q8N2G8
EPGWRRASPVTQTSP	IL16	676	Q14005
RSPTSPRWDPTGEQR	NES	1306	P48681
ARPPSPPLSSWERVS	KIF1C	911	O43896
GDPQPVISWVTPRRR	LINGO2	436	Q7L985
RFRPPTNLRSVSPWA	IL17D	81	Q8TAD2
ELSSVPPSSIWAVRP	MSLN	456	Q13421
EPTFRWTSLTRELPP	KMT2B	606	Q9UMN6
SRWASPPLKTSPQLR	KMT2B	1926	Q9UMN6
PTPQITWTRSDSSPV	LRIT3	281	Q3SXY7
TWIRIPSETRAPLAQ	OTUD7A	441	Q8TE49
LWLPTASPSPAQTRI	PLA2G4F	71	Q68DD2
TRAPWRTPAAPRSSR	H1-7	141	Q75WM6
PKPLTLRWEPSSQST	HLA-B	291	P01889
ARSWLSPRVSPPASP	MMACHC	266	Q9Y4U1
TTAPSTAPLAPRIKW	ACAN	61	P16112
PRKLPQRSWAASIPT	MED14	1161	O60244
PLPTWNARTREPVTD	MORC2	146	Q9Y6X9
QPWTTAPRAASRAPD	GRIN3A	56	Q8TCU5
AVRSRSWPASPRGPQ	PTOV1	31	Q86YD1
RHPSSEPALRPWRTT	PROX2	371	Q3B8N5
PDTLTPPWVRQRAVT	MON1A	66	Q86VX9
RRFQPPESPSSWTGI	NLGN4Y	86	Q8NFZ3
PVRAPRTLQPQHWTT	ARHGAP29	1151	Q52LW3
SSSVPATPGRRLWRQ	BTBD18	286	B2RXH4
TPSTPRPTPQDWLHR	ADAMTS4	806	O75173
TQPFWGSLTNRTRPP	HLA-DMB	101	P28068
RSWSQAFPRPTVVLP	FHAD1	146	B1AJZ9
RSCTWPLPRPEFSQS	FOXO1	21	Q12778
PRSVDETTVPAWRPQ	DACT2	176	Q5SW24
WNPVPRTRQEPTSES	BTAF1	76	O14981
PPPSSVNRRLWTGRQ	DENND2A	311	Q9ULE3
TPNSLLVSWQPPRAR	FN1	2006	P02751
SLSVSWSIPPPQQSR	EPHA2	451	P29317
SNESVIVAWTLPRPP	CPAMD8	1056	Q8IZJ3
PSNPRRLEVTWQTPS	CNTFR	216	P26992
APRTLPWPKSSDTIS	ESAM	291	Q96AP7
RRQPQEGIWVLTPPS	MAST2	951	Q6P0Q8
PSPTRPLQRQTTWAG	DENND4B	931	O75064
TPSKSVLPRTPESWR	FOXM1	611	Q08050
STSTPEPTRKPWERT	ENAH	486	Q8N8S7
STPSVRQPDPSAWLS	C1orf127	501	Q8N9H9
TRTVTPLRWQPAPRS	HELZ2	1546	Q9BYK8
LPRSQATVTLPTWQP	DNER	166	Q8NFT8
PQSTLRPESWPVRIS	DMBT1	206	Q9UGM3
TPRPDTWLTTNLPAL	DMBT1	1616	Q9UGM3
ETSSPKLPSWRPPRS	PPRC1	216	Q5VV67
AKRITTEQPPPRSWI	CNOT6	161	Q9ULM6
ASPLPSEWTSVRISP	MICAL2	1136	O94851
TTVRVSWVPPPADSR	PTPRF	621	P10586
PESETSILLSWTPPR	PTPRD	526	P23468
SDATSPTSRWAPRRP	RIN3	266	Q8TB24
SPQTWPRRTRPRSPE	MTX1	31	Q13505
RSRPIRWSLPSSSPK	MROH5	351	Q6ZUA9
SVEQEPDPSRRPQSW	GPRASP1	1031	Q5JY77
RPSSWLPPTVSVLAL	RUSC1	806	Q9BVN2
RPPELPARATATWFS	HHLA1	286	C9JL84
EQLRARSAWLPPSQP	TNNT1	201	P13805
DEAVVSVPQPRSPRW	TMEM132C	741	Q8N3T6
SVPQPRSPRWPVVVA	TMEM132C	746	Q8N3T6
TLSARPSTQPRPDSW	SCYL1	741	Q96KG9
SLPETQSRASRPWPF	LRRC56	281	Q8IYG6
LSPLSPRAVASQWPE	SORCS3	56	Q9UPU3
LTLSVSRPEGRSWPS	PDLIM4	76	P50479
ASVSPRPPIRQWRTQ	PRR14	301	Q9BWN1
SSVPTRPRTPNRDSW	FAM120AOS	26	Q5T036
PPIRRQPTWSRSSLP	PTPN14	316	Q15678
VQSPPDTGRRLPWST	PPM1J	91	Q5JR12
AAWTSSRPARPAPLS	SHISA8	326	B8ZZ34
PSIRSPAQRARGPWI	SEM1	31	Q6ZVN7
TLPWRTTRRPGSSSP	SSC5D	906	A1L4H1
ARTAPWSSALPQPST	OLFML2B	366	Q68BL8
PLSVFSANKRWTPPR	RHPN2	501	Q8IUC4
PPNLRSRSWETFPSV	SPAG17	1711	Q6Q759
IWPQEEPAIRPRSSQ	TDGF1	51	P13385
WPSEPSRVSRAVPEV	ARAP1	1401	Q96P48
RVPWLSVQTAAPSPL	CHPF	581	Q8IZ52
ATVITTRRPRPWQKP	CSNK1G2-AS1	16	Q8NCQ2
TSPVPQRTWPIRVDE	CLEC14A	311	Q86T13
RPTPRSPANWSSPLT	CLASP2	896	O75122
QVWHTAVPPPRRSSS	RNF223	6	E7ERA6
SRKPSQGQWPPLTSR	TXN2	16	Q99757
LVSWQRAFVDRTPPP	TJAP1	411	Q5JTD0
EGRAWPLPSSSRPQR	TJAP1	516	Q5JTD0
RLITEPPQATLWSPS	TSC1	336	Q92574
TPQEWAPQTARIRTR	TOR1AIP1	286	Q5JTV8
LPSTWITDTIPRRCP	PHIP	941	Q8WWQ0
PSQSTVPRSPDWKRS	SRRM5	641	B3KS81
VPRSPDWKRSPTRTS	SRRM5	646	B3KS81
QPSSPLLPRTSVLDW	PRR19	311	A6NJB7
QPWTTPRSREVAREV	TTI2	161	Q6NXR4
TARALAVNPRDPPSW	TLN1	1616	Q9Y490
EVTRQSALISWQPPR	TNR	1051	Q92752
PPRAWATRSPSTASL	nan	146	Q9UF83
TRTPSRASLTRWPPR	nan	161	Q9UF83
RASLTRWPPRASPTR	nan	166	Q9UF83
QSWSPRLESPRAPTN	HIVEP3	2326	Q5T1R4
RRSQWESPSPTPSYR	DHX38	226	Q92620
SFPAPVSTPLEVWTR	ARHGAP31	706	Q2M1Z3
QWVPVCSRLIPVSPT	UQCC1	16	Q9NVA1
VPRRIWVTASVTPSP	nan	96	A1L4Q6
NTSLPPLWSPEAERS	NUP153	201	P49790
VPWRNLTSSPTRPLA	nan	31	Q6Q795
PITVQPTEAWPRTSQ	TNFRSF4	186	P43489
PTEAWPRTSQGPSTR	TNFRSF4	191	P43489
RSPPVRPNESLSGSW	ZNF704	101	Q6ZNC4
TNPWSRASSEPLPVQ	TEX13A	281	Q9BXU3
SPWTPAAQARVRDAP	ZNF16	21	P17020
ELRRTAPSPWSPAAS	USP34	506	Q70CQ2
EPRDPWSRTQKPLSP	ZNF831	521	Q5JPB2
RATTRSPSWTAPPVI	ZFAND2B	176	Q8WV99
NTRTTTWERPQPLPP	WWP1	371	Q9H0M0
PSSRPRLLWQTPTTQ	PRSS50	66	Q9UI38
PSRTSPQAPRARAWA	PVRIG	206	Q6DKI7
TPTPRPLTTDWRILS	nan	16	Q6ZTI0
IWPQEEPAIRPRSSQ	TDGF1P3	51	P51864
ATPPSSRRVWSPPRV	ZBTB22	606	O15209
NRTTPVWPIPRSSLE	THEG	211	Q9P2T0
LPAPTTRRRQSPWTR	ZDHHC1	436	Q8WTX9
RWPRPLTTLATAVTG	TMEM198	166	Q66K66
WVSVRPLPSIRNFPQ	ZC3H7B	741	Q9UGR2
LQEPAPTWTPRTTRT	GARIN5B	156	Q8N5Q1
PRERRTESPPVFTWT	JPH3	571	Q8WXH2
PPLSDVSRVSRRPAW	GRIN2C	986	Q14957