Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionfloppase activity

ATP11C ATP11A ABCA2

4.06e-0716193GO:0140328
GeneOntologyMolecularFunctionpeptide lactyltransferase (CoA-dependent) activity

CREBBP EP300

8.58e-072192GO:0120300
GeneOntologyMolecularFunctionhistone H3K27 acetyltransferase activity

CREBBP EP300

8.58e-072192GO:0044017
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ATP11C ATP11A ABCA2

2.36e-0628193GO:0140326
GeneOntologyMolecularFunctionhistone H3K18 acetyltransferase activity

CREBBP EP300

2.57e-063192GO:0043993
GeneOntologyMolecularFunctionphosphatidylserine flippase activity

ATP11C ATP11A

8.56e-065192GO:0140346
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ATP11C ATP11A ABCA2

1.48e-0551193GO:0140303
GeneOntologyMolecularFunctionphosphatidylethanolamine flippase activity

ATP11C ATP11A

1.80e-057192GO:0090555
GeneOntologyMolecularFunctionaminophospholipid flippase activity

ATP11C ATP11A

1.80e-057192GO:0015247
GeneOntologyMolecularFunctionphosphatidylserine floppase activity

ATP11C ATP11A

3.08e-059192GO:0090556
GeneOntologyMolecularFunctionglycerophospholipid flippase activity

ATP11C ATP11A

7.75e-0514192GO:0140333
GeneOntologyMolecularFunctionhistone H3 acetyltransferase activity

CREBBP EP300

8.94e-0515192GO:0010484
GeneOntologyMolecularFunctionflippase activity

ATP11C ATP11A

1.16e-0417192GO:0140327
GeneOntologyMolecularFunctionperoxisome proliferator activated receptor binding

CREBBP EP300

1.78e-0421192GO:0042975
GeneOntologyMolecularFunctionbHLH transcription factor binding

CREBBP EP300

5.60e-0437192GO:0043425
GeneOntologyMolecularFunctionlipid transporter activity

ATP11C ATP11A ABCA2

8.04e-04196193GO:0005319
GeneOntologyMolecularFunctionnon-membrane spanning protein tyrosine kinase activity

MELK BMX

8.66e-0446192GO:0004715
GeneOntologyMolecularFunctionhistone acetyltransferase activity

CREBBP EP300

1.06e-0351192GO:0004402
GeneOntologyMolecularFunctiontranscription coactivator binding

CREBBP EP300

1.19e-0354192GO:0001223
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

CREBBP EP300

1.24e-0355192GO:0061733
GeneOntologyMolecularFunctionhistone modifying activity

CREBBP EP300 PRDM2

1.26e-03229193GO:0140993
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

CREBBP EP300

1.47e-0360192GO:0034212
GeneOntologyMolecularFunctionphospholipid transporter activity

ATP11C ATP11A

2.22e-0374192GO:0005548
GeneOntologyMolecularFunctionp53 binding

CREBBP EP300

2.41e-0377192GO:0002039
GeneOntologyMolecularFunctionN-acetyltransferase activity

CREBBP EP300

2.47e-0378192GO:0008080
GeneOntologyMolecularFunctiondamaged DNA binding

CREBBP EP300

2.85e-0384192GO:0003684
GeneOntologyMolecularFunctionSMAD binding

CREBBP EP300

2.99e-0386192GO:0046332
GeneOntologyMolecularFunctionN-acyltransferase activity

CREBBP EP300

4.17e-03102192GO:0016410
GeneOntologyMolecularFunctionacetyltransferase activity

CREBBP EP300

4.34e-03104192GO:0016407
GeneOntologyMolecularFunctiontranscription coregulator binding

CREBBP EP300

7.72e-03140192GO:0001221
GeneOntologyMolecularFunctionATP hydrolysis activity

ATP11C ATP11A ABCA2

7.97e-03441193GO:0016887
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

MELK BMX

8.26e-03145192GO:0004713
GeneOntologyMolecularFunctionchromatin DNA binding

CREBBP EP300

1.08e-02167192GO:0031490
GeneOntologyMolecularFunctionserine-type endopeptidase activity

PCSK4 PCSK6

1.38e-02190192GO:0004252
GeneOntologyMolecularFunctionheparin binding

PCSK6 LXN

1.41e-02192192GO:0008201
GeneOntologyMolecularFunctionendopeptidase regulator activity

ABCA2 LXN

1.54e-02201192GO:0061135
GeneOntologyMolecularFunctionserine-type peptidase activity

PCSK4 PCSK6

1.63e-02207192GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

PCSK4 PCSK6

1.70e-02212192GO:0017171
GeneOntologyMolecularFunctionATP-dependent activity

ATP11C ATP11A ABCA2

1.94e-02614193GO:0140657
GeneOntologyBiologicalProcessN-terminal peptidyl-lysine acetylation

CREBBP EP300

4.82e-064192GO:0018076
GeneOntologyBiologicalProcessaminophospholipid translocation

ATP11C ATP11A

1.68e-057192GO:0140331
GeneOntologyBiologicalProcesslipid translocation

ATP11C ATP11A ABCA2

2.19e-0560193GO:0034204
GeneOntologyBiologicalProcessregulation of membrane lipid distribution

ATP11C ATP11A ABCA2

2.79e-0565193GO:0097035
GeneOntologyBiologicalProcessaminophospholipid transport

ATP11C ATP11A

2.88e-059192GO:0015917
GeneOntologyBiologicalProcessN-terminal protein amino acid acetylation

CREBBP EP300

9.57e-0516192GO:0006474
GeneOntologyBiologicalProcessregulation of cellular response to heat

CREBBP EP300

9.57e-0516192GO:1900034
GeneOntologyBiologicalProcessstimulatory C-type lectin receptor signaling pathway

CREBBP EP300

2.01e-0423192GO:0002223
GeneOntologyBiologicalProcesscellular response to lectin

CREBBP EP300

2.01e-0423192GO:1990858
GeneOntologyBiologicalProcessresponse to lectin

CREBBP EP300

2.01e-0423192GO:1990840
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

HOXA13 CREBBP EP300 PCSK6

2.50e-04347194GO:0090092
GeneOntologyBiologicalProcesspeptidyl-lysine acetylation

CREBBP EP300

3.00e-0428192GO:0018394
GeneOntologyBiologicalProcessN-terminal protein amino acid modification

CREBBP EP300

3.22e-0429192GO:0031365
GeneOntologyBiologicalProcesspositive regulation of cellular response to transforming growth factor beta stimulus

CREBBP EP300

4.70e-0435192GO:1903846
GeneOntologyBiologicalProcesspositive regulation of transforming growth factor beta receptor signaling pathway

CREBBP EP300

4.70e-0435192GO:0030511
GeneOntologyBiologicalProcessphospholipid metabolic process

NOTUM BMX ABCA2 ALOX15B

4.71e-04410194GO:0006644
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

HOXA13 CREBBP EP300 PCSK6

4.79e-04412194GO:0090287
GeneOntologyBiologicalProcesspositive regulation of glycoprotein biosynthetic process

EP300 ABCA2

4.97e-0436192GO:0010560
GeneOntologyBiologicalProcesspositive regulation of glycoprotein metabolic process

EP300 ABCA2

6.14e-0440192GO:1903020
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

HOXA13 CREBBP EP300 PCSK6

6.41e-04445194GO:0141091
GeneOntologyBiologicalProcessface morphogenesis

CREBBP EP300

6.45e-0441192GO:0060325
GeneOntologyBiologicalProcesspeptide hormone processing

PCSK4 PCSK6

6.45e-0441192GO:0016486
GeneOntologyBiologicalProcessmacrophage derived foam cell differentiation

EP300 ALOX15B

6.45e-0441192GO:0010742
GeneOntologyBiologicalProcessfoam cell differentiation

EP300 ALOX15B

7.10e-0443192GO:0090077
GeneOntologyBiologicalProcesssignaling receptor ligand precursor processing

PCSK4 PCSK6

8.12e-0446192GO:0140448
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

HOXA13 CREBBP EP300 PCSK6

8.64e-04482194GO:0007178
GeneOntologyBiologicalProcessresponse to temperature stimulus

CREBBP EP300 LXN

8.69e-04208193GO:0009266
GeneOntologyBiologicalProcesshead morphogenesis

CREBBP EP300

8.84e-0448192GO:0060323
GeneOntologyBiologicalProcessphospholipid translocation

ATP11C ATP11A

1.16e-0355192GO:0045332
GeneOntologyBiologicalProcessprotein destabilization

CREBBP EP300

1.20e-0356192GO:0031648
GeneOntologyBiologicalProcessprotein deacylation

NOTUM EP300

1.29e-0358192GO:0035601
GeneOntologyBiologicalProcessprostate gland development

HOXA13 ALOX15B

1.47e-0362192GO:0030850
GeneOntologyBiologicalProcessmacromolecule deacylation

NOTUM EP300

1.52e-0363192GO:0098732
GeneOntologyBiologicalProcessface development

CREBBP EP300

1.52e-0363192GO:0060324
GeneOntologyBiologicalProcessbody morphogenesis

CREBBP EP300

1.57e-0364192GO:0010171
GeneOntologyBiologicalProcessprotein acetylation

CREBBP EP300

1.77e-0368192GO:0006473
GeneOntologyBiologicalProcesspositive regulation of striated muscle cell differentiation

EP300 ATP11A

1.77e-0368192GO:0051155
GeneOntologyBiologicalProcessregulation of glycoprotein biosynthetic process

EP300 ABCA2

1.82e-0369192GO:0010559
GeneOntologyCellularComponentphospholipid-translocating ATPase complex

ATP11C ATP11A

7.08e-0514192GO:1990531
HumanPhenoAortic isthmus hypoplasia

CREBBP EP300

1.16e-06262HP:0034227
HumanPhenoPlantar crease between first and second toes

CREBBP EP300

1.16e-06262HP:0008107
HumanPhenoHigh axial triradius

CREBBP EP300

1.16e-06262HP:0001042
HumanPhenoHumoral immunodeficiency

CREBBP EP300

3.47e-06362HP:0005363
HumanPhenoProminent nasal septum

CREBBP EP300

3.47e-06362HP:0005322
HumanPhenoRadial deviation of thumb terminal phalanx

CREBBP EP300

3.47e-06362HP:0005895
HumanPhenoLaryngeal cartilage malformation

CREBBP EP300

3.47e-06362HP:0008752
HumanPhenoPhobia

CREBBP EP300

3.47e-06362HP:5200232
HumanPhenoAgoraphobia

CREBBP EP300

3.47e-06362HP:0000756
HumanPhenoTrichiasis

CREBBP EP300

6.93e-06462HP:0001128
HumanPhenoWidened distal phalanges

CREBBP EP300

6.93e-06462HP:0006200
HumanPhenoVisceral hemangioma

CREBBP EP300

6.93e-06462HP:0410266
HumanPhenoTalon cusp

CREBBP EP300

6.93e-06462HP:0011087
HumanPhenoVascular ring

CREBBP EP300

6.93e-06462HP:0010775
HumanPhenoHepatic hemangioma

CREBBP EP300

6.93e-06462HP:0031207
HumanPhenoPapillary cystadenoma of the epididymis

CREBBP EP300

1.15e-05562HP:0009715
HumanPhenoSupernumerary cusp

CREBBP EP300

1.15e-05562HP:0033777
HumanPhenoEpididymal neoplasm

CREBBP EP300

1.15e-05562HP:0030421
HumanPhenoShort first metatarsal

HOXA13 EP300

1.15e-05562HP:0010105
HumanPhenoAbnormal hallux phalanx morphology

HOXA13 CREBBP EP300

1.35e-054663HP:0010057
HumanPhenoLarge foramen magnum

CREBBP EP300

1.73e-05662HP:0002700
HumanPhenoAbnormal proximal phalanx morphology of the hand

HOXA13 CREBBP EP300

1.96e-055263HP:0009834
HumanPhenoDeviated nasal septum

CREBBP EP300

2.42e-05762HP:0004411
HumanPhenoAplasia/hypoplasia of the 1st metatarsal

HOXA13 EP300

3.23e-05862HP:0010067
HumanPhenoAplasia/hypoplasia of proximal toe phalanx

HOXA13 EP300

3.23e-05862HP:0010203
HumanPhenoShort phalanx of hallux

HOXA13 EP300

3.23e-05862HP:0010111
HumanPhenoPilomatrixoma

CREBBP EP300

4.15e-05962HP:0030434
HumanPhenoCervical cord compression

CREBBP EP300

4.15e-05962HP:0002341
HumanPhenoFrontal hirsutism

CREBBP EP300

5.18e-051062HP:0011335
HumanPhenoAbnormal subclavian artery morphology

CREBBP EP300

6.33e-051162HP:0031251
HumanPhenoHypoplasia of the phalanges of the toes

HOXA13 EP300

7.59e-051262HP:0010746
HumanPhenoFacial grimacing

CREBBP EP300

8.97e-051362HP:0000273
HumanPhenoAbnormality of the first metatarsal bone

HOXA13 EP300

8.97e-051362HP:0010054
HumanPhenoAplasia/Hypoplasia of the phalanges of the hallux

HOXA13 EP300

8.97e-051362HP:0010058
HumanPhenoKeloids

CREBBP EP300

8.97e-051362HP:0010562
HumanPhenoDeviation of the hallux

HOXA13 CREBBP EP300

9.60e-058863HP:0010051
HumanPhenoParietal foramina

CREBBP EP300

1.05e-041462HP:0002697
HumanPhenoDuplication of phalanx of hallux

CREBBP EP300

1.05e-041462HP:0010066
HumanPhenoAbnormality of toe proximal phalanx

HOXA13 EP300

1.05e-041462HP:0010184
HumanPhenoHypoplastic aortic arch

CREBBP EP300

1.05e-041462HP:0012304
HumanPhenoSocial and occupational deterioration

CREBBP EP300

1.21e-041562HP:0007086
HumanPhenoDuplication of phalanx of toe

CREBBP EP300

1.21e-041562HP:0010181
HumanPhenoSquare face

CREBBP EP300

1.38e-041662HP:0000321
HumanPhenoPremature thelarche

CREBBP EP300

1.56e-041762HP:0010314
HumanPhenoFacial hirsutism

CREBBP EP300

1.75e-041862HP:0009937
HumanPhenoSkin appendage neoplasm

CREBBP EP300

1.75e-041862HP:0012842
HumanPhenoAbsent earlobe

CREBBP EP300

2.18e-042062HP:0000387
HumanPhenoDeviation of toes

HOXA13 CREBBP EP300

2.30e-0411863HP:0100498
HumanPhenoLocalized hirsutism

CREBBP EP300

2.40e-042162HP:0009889
HumanPhenoDeep plantar creases

CREBBP EP300

2.40e-042162HP:0001869
HumanPhenoCorneal scarring

CREBBP EP300

2.40e-042162HP:0000559
HumanPhenoShort thumb

HOXA13 CREBBP EP300

2.87e-0412763HP:0009778
HumanPhenoAbnormal foramen magnum morphology

CREBBP EP300

2.89e-042362HP:0002699
HumanPhenoAgenesis of permanent teeth

CREBBP EP300

2.89e-042362HP:0006349
HumanPhenoAbnormal toe phalanx morphology

HOXA13 CREBBP EP300

3.07e-0413063HP:0010161
HumanPhenoSimple ear

CREBBP EP300

3.15e-042462HP:0020206
HumanPhenoBroad hallux phalanx

CREBBP EP300

3.15e-042462HP:0010059
HumanPhenoShawl scrotum

CREBBP EP300

3.43e-042562HP:0000049
HumanPhenoMinor feet anomalies

CREBBP EP300

3.71e-042662HP:0010613
HumanPhenoAbnormal feet morphology

CREBBP EP300

3.71e-042662HP:0010611
HumanPhenoPhonophobia

CREBBP EP300

3.71e-042662HP:0002183
HumanPhenoPerimembranous ventricular septal defect

CREBBP EP300

3.71e-042662HP:0011682
HumanPhenoFlared iliac wing

CREBBP EP300

4.01e-042762HP:0002869
HumanPhenoBroad distal phalanx of finger

CREBBP EP300

4.01e-042762HP:0009836
HumanPhenoAbnormal scrotum morphology

HOXA13 CREBBP EP300

4.07e-0414363HP:0000045
HumanPhenoShort columella

CREBBP EP300

4.63e-042962HP:0002000
HumanPhenoAbnormal parietal bone morphology

CREBBP EP300

4.63e-042962HP:0002696
HumanPhenoBroad eyebrow

CREBBP EP300

4.63e-042962HP:0011229
HumanPhenoAplasia/Hypoplasia of the thumb

HOXA13 CREBBP EP300

4.69e-0415063HP:0009601
HumanPhenoAvascular necrosis of the capital femoral epiphysis

CREBBP EP300

4.96e-043062HP:0005743
HumanPhenoAbnormal epididymis morphology

CREBBP EP300

4.96e-043062HP:0009714
HumanPhenoPreaxial foot polydactyly

CREBBP EP300

4.96e-043062HP:0001841
HumanPhenoHypoplastic iliac wing

CREBBP EP300

5.30e-043162HP:0002866
HumanPhenoRecurrent urinary tract infections

HOXA13 CREBBP EP300

5.37e-0415763HP:0000010
HumanPhenoUrinary tract infections

HOXA13 CREBBP EP300

5.57e-0415963HP:0000094
HumanPhenoUrinary bladder inflammation

HOXA13 CREBBP EP300

5.57e-0415963HP:0100577
HumanPhenoAbnormal pulmonary valve physiology

CREBBP EP300 ATP11A

5.99e-0416363HP:0031654
HumanPhenoFrontal upsweep of hair

CREBBP EP300

6.01e-043362HP:0002236
HumanPhenoSyringomyelia

CREBBP EP300

6.01e-043362HP:0003396
HumanPhenoAbnormal branching pattern of the aortic arch

CREBBP EP300

6.01e-043362HP:0011587
HumanPhenoAspiration

CREBBP EP300

6.38e-043462HP:0002835
HumanPhenoAbnormal number of permanent teeth

CREBBP EP300

6.76e-043562HP:0011044
HumanPhenoHydrocele testis

CREBBP EP300

7.16e-043662HP:0000034
HumanPhenoDisturbance of facial expression

CREBBP EP300

7.16e-043662HP:0005324
HumanPhenoAbnormality of the distal phalanx of the thumb

CREBBP EP300

7.16e-043662HP:0009617
HumanPhenoAplasia/Hypoplasia of the phalanges of the toes

HOXA13 EP300

7.16e-043662HP:0010173
HumanPhenoNasolacrimal duct obstruction

CREBBP EP300

7.16e-043662HP:0000579
HumanPhenoAbnormal distal phalanx morphology of finger

HOXA13 CREBBP EP300

7.26e-0417463HP:0009832
HumanPhenoAuditory sensitivity

CREBBP EP300

7.56e-043762HP:0025112
HumanPhenoAccessory spleen

CREBBP EP300

7.56e-043762HP:0001747
HumanPhenoAuditory hypersensitivity

CREBBP EP300

7.56e-043762HP:5200060
HumanPhenoNasogastric tube feeding in infancy

CREBBP EP300

7.56e-043762HP:0011470
HumanPhenoNatal tooth

CREBBP EP300

7.98e-043862HP:0000695
HumanPhenoShort hallux

HOXA13 EP300

7.98e-043862HP:0010109
HumanPhenoCapillary hemangioma

CREBBP EP300

8.40e-043962HP:0005306
HumanPhenoCellular immunodeficiency

CREBBP EP300

8.40e-043962HP:0005374
HumanPhenoPoor coordination

CREBBP EP300

8.40e-043962HP:0002370
HumanPhenoAbnormal hair whorl

CREBBP EP300

9.75e-044262HP:0010721
HumanPhenoJuvenile aseptic necrosis

CREBBP EP300

1.02e-034362HP:0100323
HumanPhenoAplasia/Hypoplasia of the hallux

HOXA13 EP300

1.02e-034362HP:0008362
MousePhenothin myocardium compact layer

CREBBP EP300 ATP11A

2.20e-0546173MP:0004057
MousePhenoabnormal myocardium compact layer morphology

CREBBP EP300 ATP11A

6.82e-0567173MP:0004056
MousePhenoincreased organ/body region tumor incidence

CREBBP ATP11C ATP11A PCSK6 PRDM2

8.21e-05395175MP:0010274
MousePhenoabnormal organ/body region tumor incidence

CREBBP ATP11C ATP11A PCSK6 PRDM2

8.82e-05401175MP:0013152
MousePhenolethality throughout fetal growth and development, incomplete penetrance

HOXA13 CREBBP EP300 PCSK6

9.74e-05208174MP:0011109
MousePhenoabnormal respiratory system morphology

NOTUM CREBBP EP300 ATP11A PCSK6 ALOX15B PRDM2

1.14e-041027177MP:0002132
MousePhenoabnormal heart atrium morphology

CREBBP EP300 ATP11A PCSK6

1.48e-04232174MP:0003105
MousePhenoatrial septal defect

CREBBP EP300 PCSK6

1.54e-0488173MP:0010403
MousePhenoperimembraneous ventricular septal defect

CREBBP EP300 ATP11A

1.75e-0492173MP:0010418
MousePhenoabnormal interventricular septum membranous part morphology

CREBBP EP300 ATP11A

1.81e-0493173MP:0008823
MousePhenoabnormal lung morphology

NOTUM CREBBP EP300 PCSK6 ALOX15B PRDM2

1.96e-04767176MP:0001175
MousePhenoventricular septal defect

CREBBP EP300 ATP11A PCSK6

2.33e-04261174MP:0010402
MousePhenothin ventricle myocardium compact layer

CREBBP EP300

2.61e-0420172MP:0010556
MousePhenoabnormal interatrial septum morphology

CREBBP EP300 PCSK6

2.74e-04107173MP:0000282
MousePhenoincreased tumor incidence

CREBBP ATP11C ATP11A PCSK6 PRDM2

3.26e-04530175MP:0002020
MousePhenoanemia

NOTUM CREBBP ATP11C EP300

4.28e-04306174MP:0001577
MousePhenoabnormal umbilical cord blood vessel morphology

HOXA13 ATP11A

4.45e-0426172MP:0012300
MousePhenoabnormal interventricular septum morphology

CREBBP EP300 ATP11A PCSK6

6.51e-04342174MP:0000281
MousePhenoabnormal tumor incidence

CREBBP ATP11C ATP11A PCSK6 PRDM2

7.47e-04635175MP:0002019
MousePhenoabnormal tumor susceptibility

CREBBP ATP11C ATP11A PCSK6 PRDM2

8.30e-04650175MP:0002166
MousePhenooligodactyly

HOXA13 CREBBP

1.00e-0339172MP:0000565
MousePhenoabnormal heart septum morphology

CREBBP EP300 ATP11A PCSK6

1.04e-03388174MP:0006113
MousePhenoincreased megakaryocyte cell number

CREBBP EP300

1.34e-0345172MP:0008254
MousePhenoabnormal umbilical cord morphology

HOXA13 ATP11A

1.40e-0346172MP:0001725
MousePhenoincreased nervous system tumor incidence

ATP11A PRDM2

1.40e-0346172MP:0010281
MousePhenoneoplasm

CREBBP ATP11C ATP11A PCSK6 PRDM2

1.55e-03747175MP:0002006
MousePhenolethality throughout fetal growth and development

HOXA13 CREBBP EP300 PCSK6

1.59e-03435174MP:0006208
MousePhenoabnormal nose morphology

CREBBP ATP11A PCSK6

1.72e-03201173MP:0002233
Domain-

CREBBP EP300

9.80e-0721921.10.246.20
Domainzf-TAZ

CREBBP EP300

9.80e-072192PF02135
DomainZF_TAZ

CREBBP EP300

9.80e-072192PS50134
DomainNuc_rcpt_coact_CREBbp

CREBBP EP300

9.80e-072192IPR014744
DomainHAT_KAT11

CREBBP EP300

9.80e-072192PF08214
DomainKIX

CREBBP EP300

9.80e-072192PS50952
DomainZnF_TAZ

CREBBP EP300

9.80e-072192SM00551
DomainCBP_P300_HAT

CREBBP EP300

9.80e-072192IPR031162
DomainHistone_AcTrfase_Rtt109/CBP

CREBBP EP300

9.80e-072192IPR013178
DomainDUF902

CREBBP EP300

9.80e-072192PF06001
Domain-

CREBBP EP300

9.80e-0721921.20.1020.10
DomainRING_CBP-p300

CREBBP EP300

9.80e-072192IPR010303
DomainKAT11

CREBBP EP300

9.80e-072192SM01250
Domain-

CREBBP EP300

9.80e-0721921.10.1630.10
DomainZnf_TAZ

CREBBP EP300

9.80e-072192IPR000197
DomainKIX_dom

CREBBP EP300

9.80e-072192IPR003101
DomainCreb_binding

CREBBP EP300

9.80e-072192PF09030
DomainKIX

CREBBP EP300

9.80e-072192PF02172
DomainCBP_P300_HAT

CREBBP EP300

9.80e-072192PS51727
DomainNuc_rcpt_coact

CREBBP EP300

1.47e-056192IPR009110
DomainPeptidase_S8_Asp-AS

PCSK4 PCSK6

1.47e-056192IPR023827
DomainPrprotnconvertsP

PCSK4 PCSK6

2.05e-057192IPR002884
DomainP_proprotein

PCSK4 PCSK6

2.05e-057192PF01483
DomainS8_pro-domain

PCSK4 PCSK6

2.05e-057192IPR032815
Domain-

PCSK4 PCSK6

2.05e-0571923.30.70.850
DomainS8_pro-domain

PCSK4 PCSK6

2.05e-057192PF16470
DomainPeptidase_S8_His-AS

PCSK4 PCSK6

3.51e-059192IPR022398
DomainPeptidase_S8_Ser-AS

PCSK4 PCSK6

3.51e-059192IPR023828
DomainPeptidase_S8_subtilisin-rel

PCSK4 PCSK6

4.39e-0510192IPR015500
DomainSUBTILASE_ASP

PCSK4 PCSK6

4.39e-0510192PS00136
DomainSUBTILASE_HIS

PCSK4 PCSK6

4.39e-0510192PS00137
DomainSUBTILASE_SER

PCSK4 PCSK6

4.39e-0510192PS00138
DomainPeptidase_S8

PCSK4 PCSK6

5.36e-0511192PF00082
Domain-

PCSK4 PCSK6

5.36e-05111923.40.50.200
DomainPeptidase_S8/S53_dom

PCSK4 PCSK6

5.36e-0511192IPR000209
DomainP_typ_ATPase_c

ATP11C ATP11A

8.86e-0514192IPR032630
DomainP-type_ATPase_N

ATP11C ATP11A

8.86e-0514192IPR032631
DomainP-type_ATPase_IV

ATP11C ATP11A

8.86e-0514192IPR006539
DomainPhoLip_ATPase_C

ATP11C ATP11A

8.86e-0514192PF16212
DomainPhoLip_ATPase_N

ATP11C ATP11A

8.86e-0514192PF16209
DomainPropept_inh

PCSK4 PCSK6

1.32e-0417192IPR009020
DomainZF_ZZ_2

CREBBP EP300

1.49e-0418192PS50135
DomainFurin_repeat

PCSK4 PCSK6

1.49e-0418192IPR006212
DomainZF_ZZ_1

CREBBP EP300

1.49e-0418192PS01357
DomainZZ

CREBBP EP300

1.49e-0418192PF00569
DomainFU

PCSK4 PCSK6

1.49e-0418192SM00261
DomainZnf_ZZ

CREBBP EP300

1.66e-0419192IPR000433
DomainZnF_ZZ

CREBBP EP300

1.66e-0419192SM00291
DomainBromodomain_CS

CREBBP EP300

3.14e-0426192IPR018359
Domain-

ATP11C ATP11A

4.78e-04321922.70.150.10
Domain-

ATP11C ATP11A

4.78e-04321923.40.1110.10
DomainATPase_P-typ_cyto_domN

ATP11C ATP11A

5.72e-0435192IPR023299
DomainATPase_P-typ_P_site

ATP11C ATP11A

6.05e-0436192IPR018303
DomainP_typ_ATPase

ATP11C ATP11A

6.05e-0436192IPR001757
DomainATPASE_E1_E2

ATP11C ATP11A

6.05e-0436192PS00154
DomainATPase_P-typ_transduc_dom_A

ATP11C ATP11A

6.39e-0437192IPR008250
DomainE1-E2_ATPase

ATP11C ATP11A

6.39e-0437192PF00122
DomainBROMODOMAIN_1

CREBBP EP300

6.39e-0437192PS00633
DomainBromodomain

CREBBP EP300

6.74e-0438192PF00439
DomainBROMODOMAIN_2

CREBBP EP300

7.85e-0441192PS50014
DomainBROMO

CREBBP EP300

8.24e-0442192SM00297
DomainBromodomain

CREBBP EP300

8.24e-0442192IPR001487
Domain-

CREBBP EP300

8.24e-04421921.20.920.10
Domain-

ATP11C ATP11A

1.90e-03641923.40.50.1000
Domain-

PCSK4 PCSK6

2.47e-03731922.60.120.260
DomainHAD-like_dom

ATP11C ATP11A

2.88e-0379192IPR023214
DomainGalactose-bd-like

PCSK4 PCSK6

4.05e-0394192IPR008979
PathwayBIOCARTA_PELP1_PATHWAY

CREBBP EP300

7.84e-065132MM1575
PathwayREACTOME_NFE2L2_REGULATING_INFLAMMATION_ASSOCIATED_GENES

CREBBP EP300

7.84e-065132M48020
PathwayREACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION

CREBBP EP300

7.84e-065132M27228
PathwayREACTOME_NFE2L2_REGULATING_ER_STRESS_ASSOCIATED_GENES

CREBBP EP300

7.84e-065132M48023
PathwayBIOCARTA_PELP1_PATHWAY

CREBBP EP300

1.18e-056132M22062
PathwayBIOCARTA_PPARG_PATHWAY

CREBBP EP300

1.64e-057132MM1573
PathwayBIOCARTA_PPARG_PATHWAY

CREBBP EP300

2.19e-058132M22058
PathwayREACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES

CREBBP EP300

2.19e-058132M48022
PathwayREACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION

CREBBP EP300

2.19e-058132M48024
PathwayREACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES

CREBBP EP300

2.19e-058132M46443
PathwayKEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY

CREBBP EP300

2.82e-059132M47451
PathwayREACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION

CREBBP EP300

3.52e-0510132M27945
PathwayBIOCARTA_CARM1_PATHWAY

CREBBP EP300

4.30e-0511132MM1521
PathwayREACTOME_NFE2L2_REGULATING_TUMORIGENIC_GENES

CREBBP EP300

4.30e-0511132M48021
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR

CREBBP EP300

4.30e-0511132M26924
PathwayBIOCARTA_CARM1_PATHWAY

CREBBP EP300

5.15e-0512132M7968
PathwayREACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS

CREBBP EP300

5.15e-0512132M27765
PathwayREACTOME_RUNX3_REGULATES_NOTCH_SIGNALING

CREBBP EP300

7.10e-0514132M27808
PathwayBIOCARTA_RELA_PATHWAY

CREBBP EP300

8.19e-0515132MM1339
PathwayBIOCARTA_RELA_PATHWAY

CREBBP EP300

8.19e-0515132M10183
PathwayBIOCARTA_PITX2_PATHWAY

CREBBP EP300

8.19e-0515132MM1439
PathwayREACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY

CREBBP EP300

8.19e-0515132M953
PathwayBIOCARTA_IL7_PATHWAY

CREBBP EP300

9.35e-0516132M1296
PathwayBIOCARTA_IL7_PATHWAY

CREBBP EP300

9.35e-0516132MM1420
PathwayBIOCARTA_PITX2_PATHWAY

CREBBP EP300

9.35e-0516132M8516
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS

CREBBP EP300

9.35e-0516132M27121
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES

CREBBP EP300

9.35e-0516132M27940
PathwayWP_IL6_SIGNALING_PATHWAY

CREBBP EP300 BMX

9.41e-05100133MM15826
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP EP300

1.06e-0417132MM1509
PathwayREACTOME_ZYGOTIC_GENOME_ACTIVATION_ZGA

CREBBP EP300

1.06e-0417132M48025
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

CREBBP EP300

1.19e-0418132M26942
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP EP300

1.33e-0419132M18933
PathwayREACTOME_NFE2L2_REGULATING_ANTI_OXIDANT_DETOXIFICATION_ENZYMES

CREBBP EP300

1.33e-0419132M46442
PathwayREACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP EP300

1.48e-0420132M27881
PathwayWP_HEMATOPOIETIC_STEM_CELL_GENE_REGULATION_BY_GABP_ALPHABETA_COMPLEX

CREBBP EP300

1.63e-0421132M39593
PathwayREACTOME_CD209_DC_SIGN_SIGNALING

CREBBP EP300

1.63e-0421132M27485
PathwayBIOCARTA_NTHI_PATHWAY

CREBBP EP300

1.79e-0422132MM1443
PathwayBIOCARTA_VDR_PATHWAY

CREBBP EP300

1.79e-0422132MM1370
PathwayBIOCARTA_NTHI_PATHWAY

CREBBP EP300

1.96e-0423132M2821
PathwayBIOCARTA_VDR_PATHWAY

CREBBP EP300

2.14e-0424132M13404
PathwayREACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP EP300

2.33e-0425132M27880
PathwayBIOCARTA_CARM_ER_PATHWAY

CREBBP EP300

2.52e-0426132M2499
PathwayPID_HDAC_CLASSIII_PATHWAY

CREBBP EP300

2.52e-0426132M32
PathwayREACTOME_ATTENUATION_PHASE

CREBBP EP300

2.93e-0428132M27254
PathwayPID_RETINOIC_ACID_PATHWAY

CREBBP EP300

3.37e-0430132M207
PathwayREACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION

CREBBP EP300

3.37e-0430132M936
PathwayWP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR

CREBBP EP300

3.83e-0432132M39521
PathwayWP_TYPE_2_PAPILLARY_RENAL_CELL_CARCINOMA

CREBBP EP300

4.33e-0434132M39771
PathwayPID_HIF2PATHWAY

CREBBP EP300

4.33e-0434132M44
PathwayREACTOME_EVASION_BY_RSV_OF_HOST_INTERFERON_RESPONSES

CREBBP EP300

4.59e-0435132M48246
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS

CREBBP EP300

5.42e-0438132M27757
PathwayREACTOME_HSF1_DEPENDENT_TRANSACTIVATION

CREBBP EP300

5.42e-0438132M27255
PathwayPID_FOXM1_PATHWAY

CREBBP EP300

6.00e-0440132M176
PathwayPID_IFNG_PATHWAY

CREBBP EP300

6.00e-0440132M161
PathwayREACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT

CREBBP EP300

6.62e-0442132M17541
PathwayPID_HNF3A_PATHWAY

CREBBP EP300

7.27e-0444132M285
PathwayREACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS

CREBBP EP300

7.27e-0444132M27295
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

CREBBP EP300

8.29e-0447132M7946
PathwayPID_HES_HEY_PATHWAY

CREBBP EP300

8.65e-0448132M288
PathwayREACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP EP300

8.65e-0448132M611
PathwayPID_FOXO_PATHWAY

CREBBP EP300

9.01e-0449132M136
PathwayREACTOME_HEME_SIGNALING

CREBBP EP300

9.01e-0449132M41832
PathwayREACTOME_SIGNALING_BY_NOTCH3

CREBBP EP300

9.01e-0449132M618
PathwayBIOCARTA_PPARA_PATHWAY

CREBBP EP300

1.01e-0352132M2404
PathwayPID_NFAT_3PATHWAY

CREBBP EP300

1.05e-0353132M113
PathwayPID_AR_TF_PATHWAY

CREBBP EP300

1.05e-0353132M151
PathwayWP_TGFBETA_SIGNALING_PATHWAY

CREBBP EP300

1.05e-0353132MM15880
PathwayWP_TGFBETA_RECEPTOR_SIGNALING

CREBBP EP300

1.13e-0355132M39351
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP11C ATP11A

1.13e-0355132M971
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP11C ATP11A

1.22e-0357132MM15643
PathwayREACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER

CREBBP EP300

1.26e-0358132M29616
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

CREBBP EP300

1.30e-0359132M39886
PathwayPID_P53_REGULATION_PATHWAY

CREBBP EP300

1.30e-0359132M261
PathwayREACTOME_CYTOSOLIC_SENSORS_OF_PATHOGEN_ASSOCIATED_DNA

CREBBP EP300

1.53e-0364132M27046
PathwayWP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA

CREBBP EP300

1.58e-0365132M39682
PathwayPID_RB_1PATHWAY

CREBBP EP300

1.58e-0365132M279
PathwayPID_HIF1_TFPATHWAY

CREBBP EP300

1.63e-0366132M255
PathwayPID_HDAC_CLASSI_PATHWAY

CREBBP EP300

1.63e-0366132M101
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION

CREBBP EP300

1.63e-0366132M27938
PathwayWP_UROTENSINIIMEDIATED_SIGNALING

CREBBP EP300

1.78e-0369132M48052
PathwayREACTOME_FORMATION_OF_PARAXIAL_MESODERM

CREBBP EP300

1.78e-0369132M46439
PathwayKEGG_LONG_TERM_POTENTIATION

CREBBP EP300

1.83e-0370132M3115
PathwayKEGG_RENAL_CELL_CARCINOMA

CREBBP EP300

1.83e-0370132M13266
PathwayREACTOME_CIRCADIAN_CLOCK

CREBBP EP300

1.83e-0370132M938
PathwayPID_E2F_PATHWAY

CREBBP EP300

1.99e-0373132M40
PathwayKEGG_ADHERENS_JUNCTION

CREBBP EP300

1.99e-0373132M638
PathwayREACTOME_SIGNALING_BY_NOTCH1

CREBBP EP300

2.04e-0374132M616
PathwayREACTOME_CELLULAR_RESPONSE_TO_HYPOXIA

CREBBP EP300

2.10e-0375132M641
PathwayWP_ESTROGEN_SIGNALING

CREBBP EP300

2.21e-0377132MM15934
PathwayPID_MYC_ACTIV_PATHWAY

CREBBP EP300

2.32e-0379132M66
PathwayREACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA

CREBBP EP300

2.50e-0382132M1002
PathwayREACTOME_SIGNALING_BY_NOTCH4

CREBBP EP300

2.50e-0382132M594
PathwayPID_REG_GR_PATHWAY

CREBBP EP300

2.50e-0382132M115
PathwayPID_SMAD2_3NUCLEAR_PATHWAY

CREBBP EP300

2.50e-0382132M2
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION

CREBBP EP300

2.62e-0384132M1008
PathwayPID_CMYB_PATHWAY

CREBBP EP300

2.62e-0384132M195
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

ATP11C ATP11A ABCA2 PCSK6

2.72e-03681134MM14985
PathwayWP_CLEAR_CELL_RENAL_CELL_CARCINOMA_PATHWAYS

CREBBP EP300

2.75e-0386132M39375
PathwayKEGG_TGF_BETA_SIGNALING_PATHWAY

CREBBP EP300

2.75e-0386132M2642
PathwayKEGG_PROSTATE_CANCER

CREBBP EP300

2.94e-0389132M13191
Pubmed

Loss of p300 accelerates MDS-associated leukemogenesis.

CREBBP EP300

2.83e-07219227881875
Pubmed

Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissue.

CREBBP EP300

2.83e-07219211963968
Pubmed

Molecular characterization of the histone acetyltransferase CREBBP/EP300 genes in myeloid neoplasia.

CREBBP EP300

2.83e-07219234845315
Pubmed

p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.

CREBBP EP300

2.83e-07219234813504
Pubmed

p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.

CREBBP EP300

2.83e-07219219729597
Pubmed

Endogenous CCAAT/enhancer binding protein beta and p300 are both regulated by growth hormone to mediate transcriptional activation.

CREBBP EP300

2.83e-07219215860545
Pubmed

Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.

CREBBP EP300

2.83e-0721929528808
Pubmed

Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines.

CREBBP EP300

2.83e-07219212696060
Pubmed

Further delineation of an entity caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome.

CREBBP EP300

2.83e-07219229460469
Pubmed

Rubinstein-Taybi Syndrome

CREBBP EP300

2.83e-07219220301699
Pubmed

Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer.

CREBBP EP300

2.83e-07219224551300
Pubmed

CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain.

CREBBP EP300

2.83e-07219236109165
Pubmed

Potential biomarker of metformin action.

CREBBP EP300

2.83e-07219224639469
Pubmed

The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.

CREBBP EP300

2.83e-07219237816914
Pubmed

Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300.

CREBBP EP300

2.83e-07219212242694
Pubmed

Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma.

CREBBP EP300

2.83e-07219233911074
Pubmed

The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.

CREBBP EP300

2.83e-0721929018065
Pubmed

Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure.

CREBBP EP300

2.83e-07219224648406
Pubmed

CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.

CREBBP EP300

2.83e-07219230135524
Pubmed

Binding of p300/CBP co-activators by polyoma large T antigen.

CREBBP EP300

2.83e-07219211438528
Pubmed

Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators.

CREBBP EP300

2.83e-07219210918613
Pubmed

CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms.

CREBBP EP300

2.83e-07219231182547
Pubmed

Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.

CREBBP EP300

2.83e-07219235502657
Pubmed

CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.

CREBBP EP300

2.83e-07219239287984
Pubmed

Rubinstein-Taybi syndrome in a Saudi boy with distinct features and variants in both the CREBBP and EP300 genes: a case report.

CREBBP EP300

2.83e-07219230635043
Pubmed

p300 and cAMP response element-binding protein-binding protein in skeletal muscle homeostasis, contractile function, and survival.

CREBBP EP300

2.83e-07219231898871
Pubmed

Distribution of co-activators CBP and p300 during mouse oocyte and embryo development.

CREBBP EP300

2.83e-07219216596650
Pubmed

Phenotype and genotype in 52 patients with Rubinstein-Taybi syndrome caused by EP300 mutations.

CREBBP EP300

2.83e-07219227648933
Pubmed

Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity.

CREBBP EP300

2.83e-07219230888860
Pubmed

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.

CREBBP EP300

2.83e-07219227881443
Pubmed

The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation.

CREBBP EP300

2.83e-07219229217654
Pubmed

Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts.

CREBBP EP300

2.83e-07219219272189
Pubmed

Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis.

CREBBP EP300

2.83e-07219210610021
Pubmed

Emerging roles of p300/CBP in autophagy and autophagy-related human disorders.

CREBBP EP300

2.83e-07219237314181
Pubmed

Exon deletions of the EP300 and CREBBP genes in two children with Rubinstein-Taybi syndrome detected by aCGH.

CREBBP EP300

2.83e-07219220717166
Pubmed

Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal.

CREBBP EP300

2.83e-07219212397173
Pubmed

Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP.

CREBBP EP300

2.83e-07219210049825
Pubmed

CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding.

CREBBP EP300

2.83e-07219215641773
Pubmed

Differential contribution of p300 and CBP to regulatory element acetylation in mESCs.

CREBBP EP300

2.83e-07219232690000
Pubmed

Interaction of human immunodeficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein.

CREBBP EP300

2.83e-0721929733868
Pubmed

CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.

CREBBP EP300

2.83e-07219230953353
Pubmed

Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.

CREBBP EP300

2.83e-07219221803292
Pubmed

HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.

CREBBP EP300

2.83e-0721929811832
Pubmed

CBP/p300 acetyltransferase activity in hematologic malignancies.

CREBBP EP300

2.83e-07219227380996
Pubmed

CREBBP and p300 lysine acetyl transferases in the DNA damage response.

CREBBP EP300

2.83e-07219229170789
Pubmed

Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells.

CREBBP EP300

2.83e-07219224089570
Pubmed

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.

CREBBP EP300

2.83e-07219225893291
Pubmed

Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300.

CREBBP EP300

2.83e-07219211559821
Pubmed

Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.

CREBBP EP300

2.83e-07219221555743
Pubmed

Rubinstein-Taybi syndrome in Chinese population with four novel mutations.

CREBBP EP300

2.83e-07219233063428
Pubmed

CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells.

CREBBP EP300

2.83e-07219212646247
Pubmed

EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling.

CREBBP EP300

2.83e-07219234506759
Pubmed

Lack of somatic mutations in the catalytic domains of CREBBP and EP300 genes implies a role for histone deacetylase inhibition in myeloproliferative neoplasms.

CREBBP EP300

2.83e-07219222177454
Pubmed

Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease.

CREBBP EP300

2.83e-07219215706485
Pubmed

CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.

CREBBP EP300

2.83e-07219232576962
Pubmed

Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology.

CREBBP EP300

2.83e-07219219822209
Pubmed

X-linked hypoparathyroidism region on Xq27 is evolutionarily conserved with regions on 3q26 and 13q34 and contains a novel P-type ATPase.

ATP11C ATP11A

2.83e-07219215533723
Pubmed

AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.

CREBBP EP300

2.83e-07219239266679
Pubmed

Two types of type IV P-type ATPases independently re-establish the asymmetrical distribution of phosphatidylserine in plasma membranes.

ATP11C ATP11A

2.83e-07219236162506
Pubmed

A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis.

CREBBP EP300

2.83e-07219224522976
Pubmed

A boy with classical Rubinstein-Taybi syndrome but no detectable mutation in the CREBBP and EP300 genes.

CREBBP EP300

2.83e-07219222303793
Pubmed

Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice.

CREBBP EP300

2.83e-07219211867645
Pubmed

CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.

CREBBP EP300

2.83e-07219221847097
Pubmed

Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.

CREBBP EP300

2.83e-07219234732714
Pubmed

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.

CREBBP EP300

2.83e-07219234019788
Pubmed

Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes.

CREBBP EP300

8.48e-07319215598887
Pubmed

Dendrite development regulated by CREST, a calcium-regulated transcriptional activator.

CREBBP EP300

8.48e-07319214716005
Pubmed

The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.

CREBBP EP300

8.48e-07319225689462
Pubmed

The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB.

CREBBP EP300

8.48e-07319218070920
Pubmed

Acetylation of beta-catenin by CREB-binding protein (CBP).

CREBBP EP300

8.48e-07319211973335
Pubmed

The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression.

CREBBP EP300

8.48e-07319221967847
Pubmed

Synergistic activation of transcription by CBP and p53.

CREBBP EP300

8.48e-0731929194564
Pubmed

Regulation of NF-kappaB action by reversible acetylation.

CREBBP EP300

8.48e-07319215171256
Pubmed

p300/CBP acts as a coactivator of the cone-rod homeobox transcription factor.

CREBBP EP300

8.48e-07319210708567
Pubmed

Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.

CREBBP EP300

8.48e-07319216428436
Pubmed

Histone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotype.

CREBBP EP300

8.48e-07319222523253
Pubmed

Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators.

CREBBP EP300

8.48e-07319211823864
Pubmed

CBP and p300 are essential for renin cell identity and morphological integrity of the kidney.

CREBBP EP300

8.48e-07319219252086
Pubmed

An essential role for p300/CBP in the cellular response to hypoxia.

CREBBP EP300

8.48e-0731928917528
Pubmed

Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8.

CREBBP EP300

8.48e-07319219948376
Pubmed

E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin κ locus.

CREBBP EP300

8.48e-07319222544934
Pubmed

Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP.

CREBBP EP300

8.48e-07319227903646
Pubmed

Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP.

CREBBP EP300

8.48e-07319210673499
Pubmed

Inhibition of p300/CBP by early B-cell factor.

CREBBP EP300

8.48e-07319212748286
Pubmed

Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein.

CREBBP EP300

8.48e-07319210347196
Pubmed

p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively.

CREBBP EP300

8.48e-07319210075656
Pubmed

CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein (CBP).

CREBBP EP300

8.48e-07319220452968
Pubmed

Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression.

CREBBP EP300

8.48e-07319224340053
Pubmed

The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300.

CREBBP EP300

8.48e-07319210487758
Pubmed

Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation.

CREBBP EP300

8.48e-07319219166313
Pubmed

Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor gamma.

CREBBP EP300

8.48e-07319211884404
Pubmed

HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses.

CREBBP EP300

8.48e-07319216001085
Pubmed

Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response.

CREBBP EP300

8.48e-07319219273602
Pubmed

p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300.

CREBBP EP300

8.48e-07319211782467
Pubmed

Transcription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expression.

CREBBP EP300

8.48e-07319223922782
Pubmed

CREB-binding protein/p300 are transcriptional coactivators of p65.

CREBBP EP300

8.48e-0731929096323
Pubmed

The antibiotic drug trimethoprim suppresses tumour growth and metastasis via targeting Snail.

CREBBP EP300

8.48e-07319234855201
Pubmed

Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling.

CREBBP EP300

8.48e-0731928986769
Pubmed

Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation.

CREBBP EP300

8.48e-07319215649887
Pubmed

Expression patterns of histone acetyltransferases p300 and CBP during murine tooth development.

CREBBP EP300

8.48e-07319222179676
InteractionHOXB3 interactions

CREBBP EP300

2.70e-059182int:HOXB3
InteractionARGFX interactions

CREBBP EP300

2.70e-059182int:ARGFX
InteractionTACC2 interactions

MAP4 CREBBP EP300

4.20e-0577183int:TACC2
InteractionKLF2 interactions

CREBBP EP300

7.86e-0515182int:KLF2
InteractionBRMS1 interactions

CREBBP MRC2 EP300

8.12e-0596183int:BRMS1
InteractionDYRK1A interactions

TMEM63B CREBBP EP300 ABCA2 PCSK6

9.65e-05552185int:DYRK1A
InteractionMAML2 interactions

CREBBP EP300

1.02e-0417182int:MAML2
InteractionNEUROG1 interactions

CREBBP EP300

1.28e-0419182int:NEUROG1
InteractionSPIB interactions

CREBBP EP300

1.42e-0420182int:SPIB
InteractionCITED4 interactions

CREBBP EP300

1.57e-0421182int:CITED4
InteractionHOXB4 interactions

CREBBP EP300

1.57e-0421182int:HOXB4
InteractionPLAGL1 interactions

CREBBP EP300

1.57e-0421182int:PLAGL1
InteractionKLF13 interactions

CREBBP EP300

1.57e-0421182int:KLF13
InteractionZDHHC12 interactions

TMEM63B ATP11C ABCA2

1.69e-04123183int:ZDHHC12
InteractionCITED2 interactions

CREBBP EP300

1.89e-0423182int:CITED2
InteractionHOXD10 interactions

CREBBP EP300

1.89e-0423182int:HOXD10
InteractionTBX21 interactions

CREBBP EP300

2.06e-0424182int:TBX21
InteractionCNTN2 interactions

CREBBP EP300

2.06e-0424182int:CNTN2
InteractionNR6A1 interactions

CREBBP EP300

2.06e-0424182int:NR6A1
InteractionALX1 interactions

CREBBP EP300

2.23e-0425182int:ALX1
InteractionHOXB7 interactions

CREBBP EP300

2.42e-0426182int:HOXB7
InteractionMAGEA8 interactions

MELK MRC2 LXN

2.81e-04146183int:MAGEA8
InteractionH4C16 interactions

CREBBP EP300 PRDM2

3.16e-04152183int:H4C16
InteractionHOXD4 interactions

CREBBP EP300

3.23e-0430182int:HOXD4
InteractionCRTC1 interactions

CREBBP EP300

3.45e-0431182int:CRTC1
InteractionNEUROD1 interactions

CREBBP EP300

3.68e-0432182int:NEUROD1
InteractionPIGH interactions

TMEM63B ATP11A ABCA2

3.74e-04161183int:PIGH
InteractionTRERF1 interactions

CREBBP EP300

3.91e-0433182int:TRERF1
InteractionSLC14A1 interactions

TMEM63B ATP11C

3.91e-0433182int:SLC14A1
InteractionRXRA interactions

CREBBP EP300 ALOX15B

4.31e-04169183int:RXRA
InteractionC3orf62 interactions

CREBBP EP300

4.41e-0435182int:C3orf62
InteractionATP11A interactions

ATP11C ATP11A

4.41e-0435182int:ATP11A
InteractionE2F5 interactions

CREBBP EP300

4.66e-0436182int:E2F5
InteractionHOXB2 interactions

CREBBP EP300

4.66e-0436182int:HOXB2
InteractionCITED1 interactions

CREBBP EP300

4.93e-0437182int:CITED1
InteractionKLF1 interactions

CREBBP EP300

4.93e-0437182int:KLF1
InteractionBBC3 interactions

CREBBP EP300

5.20e-0438182int:BBC3
InteractionSERTAD2 interactions

CREBBP EP300

5.47e-0439182int:SERTAD2
InteractionRORA interactions

CREBBP EP300

5.47e-0439182int:RORA
InteractionCCN2 interactions

CREBBP EP300

5.76e-0440182int:CCN2
InteractionHOXB1 interactions

CREBBP EP300

6.05e-0441182int:HOXB1
InteractionTFF1 interactions

CREBBP EP300

6.05e-0441182int:TFF1
InteractionPROX1 interactions

CREBBP EP300

6.05e-0441182int:PROX1
InteractionPABPN1 interactions

TMEM63B MAP4 EP300

6.25e-04192183int:PABPN1
InteractionNPAS2 interactions

CREBBP EP300

6.35e-0442182int:NPAS2
InteractionJDP2 interactions

CREBBP EP300

6.35e-0442182int:JDP2
InteractionPRDM2 interactions

EP300 PRDM2

6.66e-0443182int:PRDM2
InteractionE2F1 interactions

CREBBP EP300 PRDM2

7.04e-04200183int:E2F1
InteractionTMEM230 interactions

ATP11C ATP11A

7.62e-0446182int:TMEM230
InteractionNR3C2 interactions

CREBBP EP300

7.62e-0446182int:NR3C2
InteractionCNOT3 interactions

MAP4 CREBBP EP300

7.78e-04207183int:CNOT3
InteractionRXRG interactions

MAP4 CREBBP

7.95e-0447182int:RXRG
InteractionFOSB interactions

CREBBP EP300

8.64e-0449182int:FOSB
InteractionSLC34A2 interactions

TMEM63B ATP11C

9.00e-0450182int:SLC34A2
InteractionC1QTNF9B interactions

MRC2 PCSK6

9.36e-0451182int:C1QTNF9B
InteractionEID1 interactions

CREBBP EP300

9.36e-0451182int:EID1
InteractionRARA interactions

CREBBP EP300 ALOX15B

9.65e-04223183int:RARA
InteractionMEIS1 interactions

HOXA13 CREBBP

9.73e-0452182int:MEIS1
InteractionHES6 interactions

CREBBP EP300

9.73e-0452182int:HES6
InteractionELF3 interactions

CREBBP EP300

1.05e-0354182int:ELF3
InteractionIRF5 interactions

CREBBP EP300

1.05e-0354182int:IRF5
InteractionCIITA interactions

CREBBP EP300

1.09e-0355182int:CIITA
InteractionBCL3 interactions

CREBBP EP300

1.13e-0356182int:BCL3
InteractionLDB2 interactions

CREBBP EP300

1.13e-0356182int:LDB2
InteractionSMAD1 interactions

HOXA13 CREBBP EP300

1.24e-03243183int:SMAD1
InteractionHOXB6 interactions

CREBBP EP300

1.29e-0360182int:HOXB6
InteractionMAF interactions

CREBBP EP300

1.29e-0360182int:MAF
InteractionETS2 interactions

CREBBP EP300

1.34e-0361182int:ETS2
InteractionCEBPD interactions

CREBBP EP300

1.38e-0362182int:CEBPD
InteractionHOXA10 interactions

CREBBP EP300

1.38e-0362182int:HOXA10
InteractionRBPJ interactions

HOXA13 CREBBP EP300

1.40e-03254183int:RBPJ
InteractionDEAF1 interactions

CREBBP EP300

1.47e-0364182int:DEAF1
InteractionPAX5 interactions

CREBBP EP300

1.47e-0364182int:PAX5
InteractionNFYB interactions

CREBBP EP300

1.52e-0365182int:NFYB
InteractionNKAIN1 interactions

TMEM63B ATP11C

1.52e-0365182int:NKAIN1
GeneFamilyProprotein convertase subtilisin/kexin family

PCSK4 PCSK6

1.45e-059122973
GeneFamilyATPase phospholipid transporting

ATP11C ATP11A

4.22e-05151221210
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

CREBBP EP300

5.46e-0517122486
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

CREBBP EP300

6.14e-051812291
ToppCellAT2_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

TMEM63B MRC2 ATP11A ALOX15B

1.04e-0619718442e49a8ce3118db6c2fd620d70c480b75143c828
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MELK CREBBP BMX

3.34e-0515818391d265e95156f16459924d3e4dd11c180e164eee
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NOTUM ATP11A ALOX15B

3.73e-05164183b0ed8cb6000ce8bf94444307e4b7b3574fa3fab2
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NOTUM ATP11A ALOX15B

3.73e-051641833aea6207a011ad55a1aeb2ed9fb54d31b23694b5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HOXA13 ATP11C MRC2

3.73e-05164183b6df1e67a5ce5f2d86f4e1420f4ee931f760bf4d
ToppCellAT2_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

TMEM63B ATP11A ALOX15B

5.00e-05181183ed0ea67f0607073aedf153f8d1073b35e46127c3
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic-Megakaryocytic-Megakaryocyte|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PCSK4 MRC2 LXN

5.00e-05181183c5843b89f3d362e236ff76c3279518a2fdfc1f75
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic-Megakaryocytic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PCSK4 MRC2 LXN

5.00e-0518118314c2dd946e89ba578711c2d25935b6b3d319b701
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PCSK4 MRC2 LXN

5.00e-05181183fcefb5902416c004631f4f8dd5c8f99fe3bd90bc
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Hematopoietic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PCSK4 MRC2 LXN

5.00e-051811839dc0563453e24c9d1d975e2e0e1e272487e19908
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)-|367C / Donor, Lineage, Cell class and subclass (all cells)

TMEM63B ATP11A ALOX15B

5.25e-051841832a8338e94937686a148b5433515700ca0f674058
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)|367C / Donor, Lineage, Cell class and subclass (all cells)

TMEM63B ATP11A ALOX15B

5.25e-051841830ba243cbf69b4fe6ae100a7f0314317bec38026c
ToppCellAT2_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

TMEM63B ATP11A ALOX15B

5.33e-051851833b3268e3f99121124e33086cac88479808d31630
ToppCell367C-Epithelial_cells-Epithelial-E_(AT2)|367C / Donor, Lineage, Cell class and subclass (all cells)

TMEM63B ATP11A ALOX15B

5.51e-051871830277d4e54bd4d48f30241c2951a569209423fee8
ToppCell367C-Epithelial_cells-Epithelial-E_(AT2)-|367C / Donor, Lineage, Cell class and subclass (all cells)

TMEM63B ATP11A ALOX15B

5.51e-0518718311670a85db87cbb3e78022a589632173604b0940
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM63B ATP11A ALOX15B

5.51e-051871837c44cec1c26ca5907a495f2d7e633410e2e9728f
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC2 ATP11A ALOX15B

5.68e-05189183da014519d6eb21bc2dc2ed65eafe638b42a068ed
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM63B ATP11A ALOX15B

5.68e-05189183e90ba6f6d7ba0698d04d84278aa035c28803733e
ToppCellCOVID-19-lung-AT2|COVID-19 / Disease (COVID-19 only), tissue and cell type

TMEM63B ATP11A ALOX15B

5.77e-0519018327a1a86620fe9b5ee930d388b32352206485e6d0
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

TMEM63B ATP11A ALOX15B

5.86e-05191183276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell(7)_Epithelial-E_(AT2)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

TMEM63B ATP11A ALOX15B

5.86e-051911830fc8d109d5c50957ceef5b8b8b818b0c598b1bbe
ToppCellAT2|World / shred by cell class for parenchyma

TMEM63B ATP11A ALOX15B

6.14e-05194183e773f5ef3abce7113a6b7cc7cbe68de873d4a17f
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM63B ATP11A ALOX15B

6.14e-051941830db439a544cf8f918a77058fd70319ab0e8e645e
ToppCell(7)_Epithelial_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

TMEM63B ATP11A ALOX15B

6.14e-05194183413e8b9f1e15be363a7f4a8f727af3eeb9e9a928
ToppCellnormal_Lung-Epithelial_cells-AT2|Epithelial_cells / Location, Cell class and cell subclass

MRC2 ATP11A ALOX15B

6.24e-0519518381e13fe337f1d0a83d0deb86a0df797d306cd24d
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM63B ATP11A ALOX15B

6.24e-0519518337aa6e4123d37de4de42ca68d3020f2a7686ce02
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC2 ATP11A ALOX15B

6.33e-051961837e5addaa844e66f8160e05858c341866a80aed23
ToppCell10x5'v1-week_12-13-Hematopoietic-erythroid|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TMEM63B MRC2 LXN

6.33e-051961830aae78e73d53416d857bdf21f595a0a0a0ba7944
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM63B ATP11A ALOX15B

6.33e-0519618369f27c2668a9f412b2eb6ca83d11b44863209542
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC2 ATP11A ALOX15B

6.43e-05197183bf10727fbe90b71d2ac60a11711e5f0701b3799d
ToppCell356C-Epithelial_cells-Epithelial-B_(AT2)-|356C / Donor, Lineage, Cell class and subclass (all cells)

TMEM63B ATP11A ALOX15B

6.43e-0519718306ed8f293d4ee89f14dc2f43d6cae93bbc02508a
ToppCell356C-Epithelial_cells-Epithelial-B_(AT2)|356C / Donor, Lineage, Cell class and subclass (all cells)

TMEM63B ATP11A ALOX15B

6.43e-05197183c115d0a45545ed24259ad88872231bf4d4d389d2
ToppCellAT2_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

TMEM63B ATP11A ALOX15B

6.43e-051971838b5d4e1c33a57c899c51feb9a6f347232f8910a3
ToppCell367C-Epithelial_cells-Epithelial-E_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TMEM63B ATP11A ALOX15B

6.52e-0519818385215015bb86ada0e871c413a4ecdc903a3785ca
ToppCelldistal-1-Epithelial-Alveolar_Epithelial_Type_2|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TMEM63B ATP11A ALOX15B

6.52e-05198183ce9d6b2a93c7b304414ce1b8b1a09562cf581278
ToppCell367C-Epithelial_cells-Epithelial-E_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TMEM63B ATP11A ALOX15B

6.52e-0519818338349e42a3f1fb700ff6dfd89c4bf5ff97f1a3e9
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_alveolar|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TMEM63B ATP11A ALOX15B

6.62e-051991837ebd89dff457f57a549eecee288c7a4b515b4018
ToppCellBiopsy_Other_PF-Epithelial-AT2|Biopsy_Other_PF / Sample group, Lineage and Cell type

TMEM63B ATP11A ALOX15B

6.62e-051991839a65acfe9bf500db72142469cf17bf0973540001
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_alveolar-AT2|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TMEM63B ATP11A ALOX15B

6.62e-05199183fa5ddba3ac1ebe712cd4cdc3f20339f7c715d039
ToppCellBiopsy_IPF-Epithelial-AT2|Biopsy_IPF / Sample group, Lineage and Cell type

TMEM63B ATP11A ALOX15B

6.62e-05199183c841d475703d3489161fb7904526bd7563d5fb0f
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intermediate|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

EP300 ATP11A

3.39e-0468182f1cbc6d72489272c1eb6200f64b8b6444719acda
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4-POLYDENDROCYTE_(Rostral-�migratory_stream-�(RMS)_(Notum))|Striatum / BrainAtlas - Mouse McCarroll V32

NOTUM PCSK4

3.91e-047318250a8164d967f2706344adcdc1562dc08c9f16c8f
ToppCell367C-Epithelial_cells-Epithelial-B_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TMEM177 BMX

6.88e-0497182eab10b1af9cd0ce373cd4d0316e0d7b218630584
ToppCell367C-Epithelial_cells-Epithelial-B_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TMEM177 BMX

6.88e-049718204f571708f2487b0dbd70ee507de6bf75be5f5d9
ToppCellLA-12._Cytoplasmic_Cardiomyocyte_II|LA / Chamber and Cluster_Paper

ABCA2 ALOX15B

7.75e-04103182e457f25e65a62c94685b15cd73fd3278fb94bf9c
ToppCellcontrol-Myeloid-Monocyte-derived_DC|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MAP4 CREBBP

8.52e-04108182e74e73d89d78c8d59dfdd2bd30db54b366a49d23
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P5-P5_1-Sox4-POLYDENDROCYTE_(Neurogenesis.Sox4.Hist1h2al)|Hippocampus / BrainAtlas - Mouse McCarroll V32

MELK HOXA13

1.16e-031261826072996987f7b05949adb86c9433e3302c4441d2
ToppCellNS-control-d_0-4-Myeloid-Monocyte-derived_DC|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MAP4 CREBBP

1.17e-031271821f9039d2a9e418c41716c3608d4d03574b71904a
ToppCellcontrol-Myeloid-Monocyte-derived_DC|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MAP4 CREBBP

1.19e-031281824a1f7b76b64df06531db79e427eda084374ce7b5
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

NOTUM MRC2

1.21e-03129182856255fbfc7f95642000cfd7704141b2388f7c5c
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_STALK|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

NOTUM BMX

1.25e-03131182308ddb7fe113eac5dbeb9cb0b688d9e09275ce5e
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

NOTUM BMX

1.27e-0313218206e7337de35bd7120655a22b6020604ad004c4e1
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

NOTUM MRC2

1.31e-03134182b959899c89d3a0363a3cd2309155280e0fe5ba88
ToppCellMild/Remission-B_intermediate-10|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

HOXA13 PCSK6

1.34e-031361821b3c6edcbe0eb674d2d9c838e83ebe2b93e3eec1
ToppCellMS-CD4-CD4_Treg|MS / Condition, Cell_class and T cell subcluster

NOTUM PCSK6

1.44e-03141182df257dd4dcc45c1ace57340798e150a6e932531d
ToppCellMild/Remission-B_naive-13|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

NOTUM MRC2

1.46e-0314218249873a2d9b1ae4bdbf253d1c09bf8845cc0cc917
ToppCellMegakaryocytic-erythropoietic-Erythro-cells-Erythrocyte|Erythro-cells / Lineage, cell class and subclass

TMEM63B MRC2

1.51e-031441827fbedc65314cfb06bcc527d794b5de7858f7c5ec
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

NOTUM BMX

1.51e-031441821c118b22c2ff3a526a5207d6c9d772636ee065fd
ToppCellMild/Remission-B_naive-13|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

NOTUM MRC2

1.53e-031451827827aef87f834cd0d19780417757c9386e19b22e
ToppCellCOVID-19_Moderate-multiplets|COVID-19_Moderate / disease group, cell group and cell class

MRC2 ABCA2

1.57e-03147182baf15c773d7751bc6f64d4974a22738626f2b3ff
ToppCellCOVID-19-kidney-Lymphatic_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

BMX PCSK6

1.59e-03148182f777aa1674e898e2594b2b7c029d3d05dda04df9
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P5-P5_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

MELK HOXA13

1.59e-03148182b9d3421c2eb8e748e9508c1cbd1cb4f96e23db5a
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P5-P5_1-Sox4|Hippocampus / BrainAtlas - Mouse McCarroll V32

MELK HOXA13

1.59e-031481822a7671dc27afbdf6a92d976c5f2b728bd18dd609
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

NOTUM BMX

1.61e-03149182d9c47f523c75ddcd6131e45d2ffc24b970932cae
ToppCell3'_v3-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3|bone_marrow / Manually curated celltypes from each tissue

NOTUM MRC2

1.61e-03149182d7f1069f70f3cad6d3700ee2041ed1d4cb7c49ab
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HOXA13 ABCA2

1.63e-03150182afd651c654e715414eff64cf3a37378d057a56a2
ToppCellHealthy_donor-RBC|World / disease group, cell group and cell class (v2)

PCSK4 MRC2

1.63e-031501821e1a497ec4b048f7e9cc12dd5dd9aba7fedca9e1
ToppCellP03-Epithelial-epithelial_progenitor_cell-epi_progenitor|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ATP11A ABCA2

1.65e-03151182fce04bce66411c21cd5d4d41375f26f1f50f3348
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

NOTUM MRC2

1.72e-0315418265dbb60f636562eeba3dafadae9c0c7db2b27476
ToppCellHealthy_donor-RBC|Healthy_donor / disease group, cell group and cell class (v2)

PCSK4 MRC2

1.72e-03154182e080d5104fe6f3f6ef617bbcdccf1332ab7231e1
ToppCellmild_COVID-19_(asymptomatic)-CD8+_T_naive|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

TMEM177 MRC2

1.74e-03155182e2c901d5c9e42d25d7702e5e8fc19b06f7c817be
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TMEM177 MRC2

1.74e-03155182d76a0f99ec35560d18820f9c92b69364ef2250e3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM63B MRC2

1.74e-0315518282e602f31981c6b48abff2a04b2ab5d26d4462a2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM63B MRC2

1.74e-03155182979c1d53b435a82c57d16707eed8ba7346326866
ToppCellCOVID-19_Moderate-multiplets|World / disease group, cell group and cell class

MRC2 ABCA2

1.76e-03156182afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCellNS-moderate-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PCSK4 MELK

1.78e-03157182410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Col15a1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NOTUM MRC2

1.83e-0315918234c90711c5857cf6ada7b3acff99f1d48c7caf29
ToppCell18-Airway-Epithelial-Bud_tip_progenitor|Airway / Age, Tissue, Lineage and Cell class

NOTUM ATP11A

1.83e-03159182e715cadff8e7d5ebe4c2198dbdfd3ca41ecb8a6a
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

NOTUM MRC2

1.83e-0315918292049a8d8fc9997d8d0d76500c72596a9b2394e0
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CREBBP MRC2

1.85e-031601828bb873704895c3b35bba8af78fedbabf7df42e71
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOTUM PCSK6

1.85e-03160182c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HOXA13 ATP11C

1.88e-031611821b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CREBBP BMX

1.90e-0316218293bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCellP07-Endothelial-lymphatic_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK6 ALOX15B

1.92e-031631825cbab3d03bb1af9391ecad635d6eea1dd42c1337
ToppCellP07-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK6 ALOX15B

1.92e-03163182322ba94c3ec1e1859c2e2195ecb3f7dab8d190f6
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MELK LXN

1.92e-031631827864e966c228282b4b63c43164dba3faba21026d
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

TMEM63B ALOX15B

1.94e-03164182beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

TMEM63B ALOX15B

1.94e-03164182d005cfd821b87548b075120bffe65a0be9860463
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP11A PCSK6

1.99e-03166182575c325db88d6909cdf0d5e664bd9098b89d4401
ToppCell356C-Fibroblasts-Fibroblast-D-|356C / Donor, Lineage, Cell class and subclass (all cells)

BMX PCSK6

1.99e-031661827c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell356C-Fibroblasts-Fibroblast-D|356C / Donor, Lineage, Cell class and subclass (all cells)

BMX PCSK6

1.99e-031661827286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK4 LXN

2.02e-03167182b742558ca92985db0a67c88f530bc375f3d3bb98
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOTUM ATP11A

2.02e-03167182ed7e785dcd25777f64e0c2596ada4f5a5ea17121
ToppCellfacs-Aorta-Heart-24m-Endothelial-endocardial_endothelial_cells|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMX LXN

2.04e-03168182edbab94f14e16a1a76546a18fe777a183080d1de
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP|Hippocampus / BrainAtlas - Mouse McCarroll V32

NOTUM MRC2

2.04e-0316818226aa96b2b547d11941cb803995ea3d302ee0518c
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NOTUM MRC2

2.04e-031681829930bd63b60c03f0152838a79eef77da1c2dd8e5
ToppCellMild/Remission-B_naive-4|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CREBBP PRDM2

2.06e-03169182c3a6179a64589a370108fea809b157839347759c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MELK ALOX15B

2.06e-0316918254b13ab02b4c187f4754045ecfcf409749e7ccc0
ToppCelldroplet-Kidney-nan-18m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOTUM ATP11A

2.06e-03169182f00741203efa0b948db7223ee8c19bdd0918258a
ToppCellNS-critical-LOC-Epithelial-FOXN4+|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MELK PCSK6

2.09e-03170182f6a0162bb690dbc19ff1cec64cb933744ad3b496
DrugKarakoline [39089-30-0]; Down 200; 10.6uM; MCF7; HT_HG-U133A

MAP4 ATP11A ABCA2 PCSK6 PRDM2

3.43e-071951856059_DN
Drug3,4-dimethoxy-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-N-phenylbenzenesulfonamide

CREBBP EP300

5.89e-065182ctd:C575894
DrugCyclosporin A [59865-13-3]; Down 200; 3.4uM; MCF7; HT_HG-U133A

ATP11A ABCA2 PCSK6 PRDM2

1.42e-051941844411_DN
Drugfelodipine; Down 200; 10uM; MCF7; HT_HG-U133A_EA

MAP4 MRC2 EP300 PRDM2

1.48e-05196184848_DN
DrugIsosorbide dinitrate [87-33-2]; Down 200; 17uM; HL60; HT_HG-U133A

MAP4 MRC2 ABCA2 PCSK6

1.48e-051961842183_DN
DrugMethoxy-8-psoralen [298-81-7]; Down 200; 18.6uM; MCF7; HT_HG-U133A

MAP4 ATP11A PCSK6 PRDM2

1.48e-051961843302_DN
DrugRauwolscine hydrochloride [6211-32-1]; Up 200; 10.2uM; MCF7; HT_HG-U133A

MAP4 ATP11A PCSK6 PRDM2

1.48e-051961842778_UP
DrugAlprenolol hydrochloride [13707-88-5]; Up 200; 14uM; MCF7; HT_HG-U133A

MAP4 MRC2 BMX PCSK6

1.51e-051971843188_UP
DrugEserine sulfate, physostigmine sulfate [64-47-1]; Up 200; 6.2uM; MCF7; HT_HG-U133A

MAP4 CREBBP PCSK6 PRDM2

1.54e-051981842768_UP
DrugTrimethobenzamide hydrochloride [554-92-7]; Up 200; 9.4uM; MCF7; HT_HG-U133A

CREBBP MRC2 ABCA2 PCSK6

1.54e-051981841502_UP
DrugIobenguane sulfate; Down 200; 10.8uM; MCF7; HT_HG-U133A

MAP4 ATP11A ABCA2 PCSK6

1.57e-051991842878_DN
Drugtroglitazone

MAP4 TMEM177 MELK CREBBP EP300 PCSK6 LXN

4.09e-051329187ctd:C057693
Drug4,4'-DBP

CREBBP EP300

1.00e-0419182CID000007034
DrugArginylarginine

PCSK4 PCSK6 PRDM2

2.72e-04163183CID000151956
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

CREBBP EP300 ABCA2

3.13e-041711836879_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

CREBBP EP300 PCSK6

3.23e-041731832881_DN
DrugEthaverine hydrochloride [985-13-7]; Down 200; 9.2uM; HL60; HT_HG-U133A

MAP4 MRC2 PCSK6

3.29e-041741833037_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

MAP4 CREBBP EP300

3.57e-041791835822_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

MELK CREBBP EP300

3.63e-041801836886_DN
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; PC3; HT_HG-U133A

CREBBP EP300 PRDM2

3.63e-041801834541_DN
Drug17-AAG; Up 200; 1uM; PC3; HT_HG-U133A

CREBBP MRC2 ATP11A

4.06e-041871835958_UP
DrugGW8510; Down 200; 10uM; MCF7; HT_HG-U133A

TMEM177 CREBBP PRDM2

4.06e-041871837080_DN
DrugChlorambucil [305-03-3]; Down 200; 13.2uM; PC3; HT_HG-U133A

MAP4 ABCA2 PRDM2

4.19e-041891833788_DN
DrugCyclosporin A [59865-13-3]; Up 200; 3.4uM; HL60; HT_HG-U133A

MAP4 ABCA2 PCSK6

4.19e-041891831331_UP
DrugMethoxy-6-harmalan [3589-73-9]; Up 200; 18.6uM; MCF7; HT_HG-U133A

MAP4 ATP11A PCSK6

4.19e-041891835455_UP
DrugBenzethonium chloride [121-54-0]; Down 200; 9uM; HL60; HT_HG-U133A

MAP4 ABCA2 PCSK6

4.19e-041891832508_DN
DrugMianserine hydrochloride [21535-47-7]; Up 200; 13.2uM; MCF7; HT_HG-U133A

MAP4 ATP11A PCSK6

4.19e-041891832231_UP
DrugPNU-0230031 [267429-39-0]; Up 200; 10uM; MCF7; HT_HG-U133A

MRC2 ATP11A PCSK6

4.26e-041901833629_UP
DrugEllipticine [519-23-3]; Up 200; 16.2uM; MCF7; HT_HG-U133A

MAP4 ATP11A ABCA2

4.26e-041901836253_UP
DrugDisulfiram [97-77-8]; Up 200; 13.4uM; PC3; HT_HG-U133A

MRC2 PCSK6 PRDM2

4.32e-041911835729_UP
Drug17-AAG; Down 200; 1uM; HL60; HT_HG-U133A

MAP4 TMEM177 ATP11A

4.32e-041911832685_DN
DrugRicinine [524-40-3]; Down 200; 24.4uM; HL60; HT_HG-U133A

MAP4 MRC2 PRDM2

4.46e-041931832505_DN
DrugCimetidine [51481-61-9]; Down 200; 15.8uM; MCF7; HT_HG-U133A

MAP4 ATP11A ABCA2

4.46e-041931831464_DN
DrugFenbufen [36330-85-5]; Up 200; 15.8uM; HL60; HT_HG-U133A

MAP4 ABCA2 PCSK6

4.46e-041931832346_UP
DrugCalycanthine [595-05-1]; Up 200; 11.6uM; MCF7; HT_HG-U133A

ABCA2 PCSK6 PRDM2

4.46e-041931832764_UP
DrugRemoxipride Hydrochloride [73220-03-8]; Down 200; 9.8uM; HL60; HT_HG-U133A

MAP4 MRC2 PRDM2

4.46e-041931833124_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A

MAP4 PCSK6 PRDM2

4.46e-041931832721_DN
DrugGlycocholic acid [475-31-0]; Down 200; 8.6uM; MCF7; HT_HG-U133A

MAP4 MRC2 ABCA2

4.52e-041941835316_DN
DrugTetrandrine [518-34-3]; Down 200; 6.4uM; HL60; HT_HG-U133A

MAP4 MRC2 PRDM2

4.52e-041941832520_DN
DrugProglumide [6620-60-6]; Down 200; 12uM; MCF7; HT_HG-U133A

CREBBP ABCA2 PRDM2

4.52e-041941833861_DN
DrugPicrotoxinin [17617-45-7]; Up 200; 13.6uM; PC3; HT_HG-U133A

MRC2 ATP11A PRDM2

4.52e-041941834260_UP
DrugAlsterpaullone; Up 200; 10uM; MCF7; HT_HG-U133A

MAP4 MRC2 ABCA2

4.52e-041941837051_UP
DrugFenspiride hydrochloride [5053-08-7]; Up 200; 13.4uM; HL60; HG-U133A

MAP4 ABCA2 PRDM2

4.52e-041941831422_UP
DrugCinchonine [118-10-5]; Up 200; 13.6uM; MCF7; HT_HG-U133A

MAP4 MRC2 ABCA2

4.52e-041941832789_UP
DrugAcetylsalicylsalicylic acid [530-75-6]; Down 200; 13.4uM; HL60; HG-U133A

MAP4 MRC2 ABCA2

4.52e-041941831377_DN
DrugRanitidine hydrochloride [66357-59-3]; Up 200; 11.4uM; HL60; HG-U133A

MAP4 EP300 PRDM2

4.52e-041941831404_UP
Drugsemustine; Up 200; 100uM; MCF7; HT_HG-U133A

MAP4 CREBBP PCSK6

4.52e-041941837487_UP
DrugPiperacillin sodium salt [59703-84-3]; Down 200; 7.4uM; PC3; HT_HG-U133A

MAP4 ATP11A PRDM2

4.52e-041941834320_DN
DrugSkimmianine [83-95-4]; Up 200; 15.4uM; MCF7; HT_HG-U133A

MAP4 PCSK6 PRDM2

4.52e-041941836242_UP
DrugOxyphenbutazone [129-20-4]; Down 200; 12.4uM; HL60; HT_HG-U133A

MRC2 ABCA2 PCSK6

4.52e-041941836160_DN
DrugEbselen [60940-34-3]; Down 200; 14.6uM; MCF7; HT_HG-U133A

MAP4 ABCA2 PCSK6

4.59e-041951833458_DN
DrugXylazine [7361-61-7]; Up 200; 18.2uM; HL60; HT_HG-U133A

MAP4 ABCA2 PCSK6

4.59e-041951832132_UP
Drug5279552; Down 200; 22uM; MCF7; HT_HG-U133A_EA

CREBBP EP300 PRDM2

4.59e-04195183843_DN
DrugDeoxycorticosterone [64-85-7]; Down 200; 12.2uM; MCF7; HT_HG-U133A

MELK PCSK6 PRDM2

4.59e-041951835357_DN
DrugClomiphene citrate (Z,E) [50-41-9]; Up 200; 6.6uM; MCF7; HT_HG-U133A

CREBBP MRC2 PCSK6

4.59e-041951832624_UP
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A

ATP11A ABCA2 PCSK6

4.59e-041951832208_DN
DrugEthamsylate [2624-44-4]; Down 200; 15.2uM; MCF7; HT_HG-U133A

MAP4 PCSK6 PRDM2

4.59e-041951834399_DN
DrugEthopropazine hydrochloride [1094-08-2]; Down 200; 11.4uM; MCF7; HT_HG-U133A

ABCA2 PCSK6 PRDM2

4.59e-041951833376_DN
DrugFlutamide [13311-84-7]; Down 200; 14.4uM; HL60; HT_HG-U133A

MAP4 MRC2 LXN

4.59e-041951832358_DN
DrugTetrandrine [518-34-3]; Down 200; 6.4uM; MCF7; HT_HG-U133A

MAP4 ABCA2 PCSK6

4.59e-041951836082_DN
DrugPyrithyldione [77-04-3]; Down 200; 24uM; HL60; HT_HG-U133A

MAP4 ATP11A ABCA2

4.59e-041951832740_DN
DrugClorsulon [60200-06-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A

MAP4 ABCA2 PCSK6

4.66e-041961837025_UP
DrugCephalexin monohydrate [23325-78-2]; Up 200; 11uM; MCF7; HT_HG-U133A

ABCA2 PCSK6 PRDM2

4.66e-041961832628_UP
DrugLY 294002; Down 200; 10uM; HL60; HT_HG-U133A

MAP4 TMEM177 ATP11A

4.66e-041961832687_DN
DrugTrimetazidine dihydrochloride [13171-25-0]; Up 200; 11.8uM; MCF7; HT_HG-U133A

ATP11A ABCA2 PCSK6

4.66e-041961832876_UP
DrugPaclitaxel [33069-62-4]; Up 200; 4.6uM; MCF7; HT_HG-U133A

MAP4 ATP11A ABCA2

4.66e-041961835320_UP
DrugOxolinic acid [14698-29-4]; Down 200; 15.4uM; PC3; HT_HG-U133A

MAP4 ATP11A PRDM2

4.66e-041961832103_DN
DrugMethylergometrine maleate [113-42-8]; Down 200; 8.8uM; MCF7; HT_HG-U133A

MAP4 ATP11A ABCA2

4.66e-041961833222_DN
DrugHarpagoside [19210-12-9]; Down 200; 8uM; HL60; HT_HG-U133A

ATP11A PCSK6 PRDM2

4.66e-041961832935_DN
DrugRoxarsone [121-19-7]; Up 200; 15.2uM; HL60; HT_HG-U133A

MRC2 BMX PCSK6

4.66e-041961832950_UP
DrugChlorpromazine hydrochloride [69-09-0]; Down 200; 11.2uM; HL60; HT_HG-U133A

MAP4 TMEM177 PRDM2

4.66e-041961831864_DN
DrugThiamine hydrochloride [67-03-8]; Up 200; 11.8uM; MCF7; HT_HG-U133A

MAP4 PCSK6 PRDM2

4.66e-041961837479_UP
DrugMetyrapone [54-36-4]; Up 200; 17.6uM; HL60; HT_HG-U133A

MAP4 ABCA2 PCSK6

4.66e-041961833070_UP
DrugAcyclovir [59277-89-3]; Up 200; 17.8uM; PC3; HT_HG-U133A

MRC2 ATP11A PCSK6

4.66e-041961834683_UP
DrugCP-690334-01 [459212-38-5]; Up 200; 1uM; PC3; HT_HG-U133A

CREBBP ATP11A PCSK6

4.66e-041961833826_UP
DrugProparacaine hydrochloride [5875-06-9]; Down 200; 12uM; HL60; HT_HG-U133A

MAP4 MRC2 PRDM2

4.66e-041961833113_DN
DrugAdamantamine fumarate [80789-67-9]; Up 200; 9.6uM; HL60; HT_HG-U133A

MAP4 TMEM177 ATP11A

4.66e-041961831344_UP
DrugICI182,780; Down 200; 1uM; PC3; HT_HG-U133A

MRC2 ATP11A PRDM2

4.66e-041961837495_DN
DrugBetonicine [515-25-3]; Down 200; 25.2uM; HL60; HT_HG-U133A

MAP4 MRC2 ABCA2

4.66e-041961832207_DN
DrugFluvoxamine maleate [61718-82-9]; Down 200; 9.2uM; MCF7; HT_HG-U133A

MAP4 ATP11A ABCA2

4.66e-041961837333_DN
DrugGemfibrozil [25812-30-0]; Up 200; 16uM; MCF7; HT_HG-U133A

MRC2 ABCA2 PRDM2

4.66e-041961832277_UP
DrugHydroxytacrine maleate (R,S) [118909-22-1]; Up 200; 12.2uM; HL60; HT_HG-U133A

MAP4 MRC2 PCSK6

4.66e-041961832430_UP
DrugAdiphenine hydrochloride [50-42-0]; Up 200; 11.4uM; HL60; HT_HG-U133A

MAP4 MRC2 ATP11A

4.66e-041961831872_UP
Drugdaunorubicin HCl; Up 200; 1uM; PC3; HT_HG-U133A

MRC2 ABCA2 PRDM2

4.66e-041961837511_UP
DrugFlorfenicol [73231-34-2]; Up 200; 11.2uM; HL60; HT_HG-U133A

MAP4 MRC2 ATP11A

4.66e-041961833083_UP
DrugPhenylpropanolamine hydrochloride [154-41-6]; Up 200; 21.4uM; MCF7; HT_HG-U133A

MAP4 ATP11A ABCA2

4.66e-041961835298_UP
DrugSpironolactone [52-01-7]; Up 200; 9.6uM; PC3; HT_HG-U133A

MRC2 ABCA2 PRDM2

4.66e-041961835781_UP
DrugLincomycin hydrochloride [859-18-7]; Down 200; 9uM; MCF7; HT_HG-U133A

MAP4 MRC2 PCSK6

4.66e-041961837411_DN
DrugFlumequine [42835-25-6]; Up 200; 15.4uM; MCF7; HT_HG-U133A

MRC2 ABCA2 PCSK6

4.73e-041971832276_UP
DrugCefazolin sodium salt [27164-46-1]; Up 200; 8.4uM; HL60; HT_HG-U133A

MRC2 ABCA2 PCSK6

4.73e-041971832564_UP
DrugSulfamethizole [144-82-1]; Down 200; 14.8uM; HL60; HT_HG-U133A

MRC2 PCSK6 PRDM2

4.73e-041971832536_DN
DrugAmidopyrine [58-15-1]; Up 200; 17.2uM; MCF7; HT_HG-U133A

MRC2 ATP11A PCSK6

4.73e-041971832222_UP
DrugEpitiostanol [2363-58-8]; Down 200; 13uM; MCF7; HT_HG-U133A

MAP4 ATP11A PRDM2

4.73e-041971837342_DN
DrugEsculetin [305-01-1]; Up 200; 22.4uM; MCF7; HT_HG-U133A

MAP4 ATP11A PCSK6

4.73e-041971837459_UP
Drug0316684-0000 [391209-55-5]; Up 200; 10uM; MCF7; HT_HG-U133A

MAP4 ABCA2 PRDM2

4.73e-041971837052_UP
Drugprochlorperazine dimaleate salt; Down 200; 10uM; MCF7; HT_HG-U133A

MAP4 EP300 PCSK6

4.73e-041971831640_DN
DrugPropoxycaine hydrochloride [550-83-4]; Up 200; 12uM; HL60; HT_HG-U133A

MAP4 ATP11A PCSK6

4.73e-041971836161_UP
DrugMeclocycline sulfosalicylate [73816-42-9]; Down 200; 5.8uM; MCF7; HT_HG-U133A

MAP4 ATP11A ABCA2

4.73e-041971833277_DN
Drug17-DMAG; Down 200; 0.1uM; HL60; HT_HG-U133A

EP300 ATP11A PRDM2

4.73e-041971831154_DN
DrugAjmalicine hydrochloride [4373-34-6]; Up 200; 10.2uM; MCF7; HT_HG-U133A

CREBBP ATP11A ABCA2

4.73e-041971832898_UP
DiseaseRUBINSTEIN-TAYBI SYNDROME 1

CREBBP EP300

3.51e-072182C4551859
DiseaseMenke-Hennekam syndrome

CREBBP EP300

3.51e-072182cv:C5681632
DiseaseRubinstein-Taybi syndrome (is_implicated_in)

CREBBP EP300

3.51e-072182DOID:1933 (is_implicated_in)
DiseaseRubinstein-Taybi syndrome (implicated_via_orthology)

CREBBP EP300

3.51e-072182DOID:1933 (implicated_via_orthology)
DiseaseRUBINSTEIN-TAYBI SYNDROME 1

CREBBP EP300

3.51e-072182180849
DiseaseRubinstein-Taybi syndrome due to CREBBP mutations

CREBBP EP300

3.51e-072182cv:C4551859
DiseaseRubinstein-Taybi syndrome

CREBBP EP300

3.51e-072182cv:C0035934
DiseaseRubinstein-Taybi Syndrome

CREBBP EP300

3.51e-072182C0035934
DiseaseBladder Neoplasm

CREBBP EP300 PRDM2

8.10e-05140183C0005695
DiseaseMalignant neoplasm of urinary bladder

CREBBP EP300 PRDM2

8.27e-05141183C0005684
DiseaseCarcinoma, Transitional Cell

CREBBP EP300

2.84e-0441182C0007138
DiseaseSmall cell carcinoma of lung

CREBBP EP300

4.94e-0454182C0149925
DiseaseDiffuse Large B-Cell Lymphoma

CREBBP EP300

5.12e-0455182C0079744
DiseasePrecursor Cell Lymphoblastic Leukemia Lymphoma

CREBBP EP300

6.30e-0461182C1961102
DiseaseSquamous cell carcinoma of esophagus

CREBBP EP300

1.52e-0395182C0279626
DiseaseAdenoid Cystic Carcinoma

CREBBP EP300

1.68e-03100182C0010606
DiseaseSquamous cell carcinoma

CREBBP EP300

2.56e-03124182C0007137
DiseaseLeukemia, Myelocytic, Acute

CREBBP EP300

4.92e-03173182C0023467
Diseasealcohol use disorder (implicated_via_orthology)

CREBBP EP300

6.20e-03195182DOID:1574 (implicated_via_orthology)
DiseaseAdenocarcinoma of lung (disorder)

CREBBP EP300

6.89e-03206182C0152013
Diseaseobsolete_red blood cell distribution width

TMEM63B ATP11C EP300 ATP11A

7.92e-031347184EFO_0005192
Diseasemelanoma

EP300 LXN

9.85e-03248182C0025202

Protein segments in the cluster

PeptideGeneStartEntry
YQEPWQYVDDIWLMF

EP300

1111

Q09472
NMQYIPREDFPDWWQ

BMX

231

P51813
QYQEPWQYVDDVWLM

CREBBP

1146

Q92793
PWIMQDYNYPVEWQS

MELK

261

Q14680
EKMAYQEYPNSQNWP

MAP4

106

P27816
ENNIPWYQSMFNWNP

ERVS71-1

556

P61550
PWFSKQWYMNSEAQP

PCSK4

121

Q6UW60
QALYFNDPIWSNMWY

PCSK6

156

P29122
QWVEQEPLMYANWAP

MRC2

1046

Q9UBG0
PEENPYWWNANMVFI

NOTUM

166

Q6P988
NWTVSYAPDPQNIYW

TMEM63B

406

Q5T3F8
NPIIYWLANYVWDML

ABCA2

1831

Q9BZC7
WLANYVWDMLNYLVP

ABCA2

1836

Q9BZC7
NNVYMWEVYYPNLGW

PRDM2

71

Q13029
QEMYQWKAYNPGWPH

ALOX15B

146

O15296
EIIPWQMQVLWHPQY

LXN

191

Q9BS40
YQPWALPNGWNGQMY

HOXA13

276

P31271
YMWQSEPFRDEPWYN

ATP11A

316

P98196
WQSTPYNDEPWYNQK

ATP11C

316

Q8NB49
VVQWLYQYWPQGQPA

TMEM177

41

Q53S58