Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoabnormal lung morphology

ATMIN RGPD2 SPEG RGPD1 NPAS3 FZR1 NF1 MLH1 KCNQ2 NR1H2 RXFP1 GCN1 HCK CUX1 DNAH11

3.96e-057678315MP:0001175
MousePhenoincreased respiratory system tumor incidence

RGPD2 RGPD1 FZR1 NF1 MLH1 HCK

4.09e-05107836MP:0010298
MousePhenoincreased lung tumor incidence

RGPD2 RGPD1 FZR1 NF1 MLH1 HCK

4.09e-05107836MP:0008014
MousePhenoabnormal parturition

KALRN NRK NR1H2 RXFP1

4.15e-0533834MP:0002907
MousePhenoabnormal respiratory system morphology

ATMIN RGPD2 SPEG RGPD1 NPAS3 FZR1 NF1 SCGB3A2 MLH1 KCNQ2 NR1H2 RXFP1 GCN1 HCK CUX1 RAI1 DNAH11

9.21e-0510278317MP:0002132
MousePhenoincreased lung carcinoma incidence

RGPD2 RGPD1 NF1 MLH1 HCK

9.82e-0578835MP:0008714
MousePhenoincreased carcinoma incidence

RGPD2 IQGAP2 RGPD1 FZR1 NF1 MLH1 HCK

1.67e-04197837MP:0002038
DomainLeu-rich_rpt

NLRP11 LRRN1 LRRC37A3 LRRC37A2 RSU1 AMIGO1 LRRC37A CEP78 LRRC27 XRRA1 RXFP1

8.42e-0727111411IPR001611
DomainLRRC37AB_C

LRRC37A3 LRRC37A2 LRRC37A

8.82e-0741143PF14914
DomainLRRC37_N

LRRC37A3 LRRC37A2 LRRC37A

8.82e-0741143IPR032754
DomainLRRC37AB_C

LRRC37A3 LRRC37A2 LRRC37A

8.82e-0741143IPR029423
DomainLRRC37

LRRC37A3 LRRC37A2 LRRC37A

8.82e-0741143PF15779
DomainLRRC37A/B-like

LRRC37A3 LRRC37A2 LRRC37A

8.82e-0741143IPR015753
DomainLeu-rich_rpt_typical-subtyp

LRRN1 LRRC37A3 LRRC37A2 RSU1 AMIGO1 LRRC37A LRRC27 XRRA1 RXFP1

1.39e-061771149IPR003591
DomainLRR_TYP

LRRN1 LRRC37A3 LRRC37A2 RSU1 AMIGO1 LRRC37A LRRC27 XRRA1 RXFP1

1.39e-061771149SM00369
DomainLRR

LRRN1 LRRC37A3 LRRC37A2 RSU1 AMIGO1 LRRC37A LRRC27 XRRA1 RXFP1

3.96e-062011149PS51450
Domain-

NLRP11 LRRN1 LRRC37A3 LRRC37A2 RSU1 AMIGO1 LRRC37A CEP78 LRRC27 XRRA1 RXFP1

4.34e-06321114113.80.10.10
DomainL_dom-like

NLRP11 LRRN1 LRRC37A3 LRRC37A2 RSU1 AMIGO1 LRRC37A CEP78 LRRC27 XRRA1 RXFP1

5.33e-0632811411IPR032675
DomainLRR_1

LRRN1 LRRC37A3 LRRC37A2 RSU1 AMIGO1 LRRC37A LRRC27 XRRA1 RXFP1

7.94e-062191149PF00560
DomainLRR_8

LRRN1 LRRC37A3 LRRC37A2 RSU1 AMIGO1 LRRC37A LRRC27 RXFP1

1.01e-051711148PF13855
DomainSTPPase_N

PPP1CA PPP1CC

1.10e-0431142IPR031675
DomainSTPPase_N

PPP1CA PPP1CC

1.10e-0431142PF16891
DomainTPR

RGPD2 RGPD1 TTC3 TTC7B TTC23 TTC12

1.40e-041291146SM00028
DomainTPR_repeat

RGPD2 RGPD1 TTC3 TTC7B TTC23 TTC12

1.66e-041331146IPR019734
DomainSEC14

TRIO KALRN NF1

4.62e-04251143SM00516
DomainTPR_REGION

RGPD2 RGPD1 TTC3 TTC7B TTC23 TTC12

5.27e-041651146PS50293
DomainTPR

RGPD2 RGPD1 TTC3 TTC7B TTC23 TTC12

5.27e-041651146PS50005
DomainTPR-like_helical_dom

RGPD2 RGPD1 TTC3 TTC7B TTC23 TTC12 TRAPPC10

5.71e-042331147IPR011990
DomainCRAL_TRIO

TRIO KALRN NF1

5.82e-04271143PS50191
DomainDH_1

TRIO KALRN ARHGEF11 VAV1

5.94e-04631144PS00741
DomainCRAL-TRIO_dom

TRIO KALRN NF1

6.49e-04281143IPR001251
DomainGCC2_Rab_bind

RGPD2 RGPD1

7.60e-0471142IPR032023
DomainCUT

CUX2 CUX1

7.60e-0471142PS51042
DomainCUT

CUX2 CUX1

7.60e-0471142PF02376
DomainRab_bind

RGPD2 RGPD1

7.60e-0471142PF16704
DomainCUT_dom

CUX2 CUX1

7.60e-0471142IPR003350
DomainCUT

CUX2 CUX1

7.60e-0471142SM01109
DomainRhoGEF

TRIO KALRN ARHGEF11 VAV1

7.94e-04681144SM00325
DomainRhoGEF

TRIO KALRN ARHGEF11 VAV1

8.85e-04701144PF00621
DomainDH_2

TRIO KALRN ARHGEF11 VAV1

8.85e-04701144PS50010
DomainDH-domain

TRIO KALRN ARHGEF11 VAV1

9.34e-04711144IPR000219
Domain-

TRIO KALRN ARHGEF11 VAV1

9.34e-047111441.20.900.10
DomainARM-type_fold

USP34 IPO4 CWC22 NF1 TTC12 IPO13 GCN1 UNC79

1.13e-033391148IPR016024
DomainRGS

RGSL1 RGS9 ARHGEF11

1.37e-03361143PS50132
Domain-

RGPD2 RGPD1

1.61e-031011421.10.220.60
Domain-

RGPD2 RGPD1 TTC3 TTC7B TTC23 TTC12

1.70e-0320711461.25.40.10
DomainGDS_CDC24_CS

TRIO ARHGEF11 VAV1

1.72e-03391143IPR001331
DomainRGS

RGSL1 RGS9 ARHGEF11

1.72e-03391143IPR016137
DomainGrip

RGPD2 RGPD1

1.96e-03111142SM00755
DomainGRIP

RGPD2 RGPD1

1.96e-03111142PF01465
DomainPROTEIN_KINASE_ATP

CDK16 TRIO KALRN SPEG STK32A NEK5 NRK FES HCK

2.01e-034591149PS00107
DomainCadherin_C

PCDHGA7 PCDHGA5 PCDHB7

2.14e-03421143IPR032455
DomainCadherin_C_2

PCDHGA7 PCDHGA5 PCDHB7

2.14e-03421143PF16492
DomainTPR_1

RGPD1 TTC3 TTC7B TTC12

2.25e-03901144PF00515
DomainTPR_1

RGPD1 TTC3 TTC7B TTC12

2.25e-03901144IPR001440
DomainProtein_kinase_ATP_BS

CDK16 KALRN SPEG STK32A NEK5 NRK FES HCK

2.27e-033791148IPR017441
DomainTPR-contain_dom

RGPD2 RGPD1 TTC3 TTC7B TTC12

2.27e-031501145IPR013026
DomainRan_BP1

RGPD2 RGPD1

2.34e-03121142PF00638
DomainGRIP_dom

RGPD2 RGPD1

2.34e-03121142IPR000237
DomainGRIP

RGPD2 RGPD1

2.34e-03121142PS50913
DomainRANBD1

RGPD2 RGPD1

2.34e-03121142PS50196
DomainSer/Thr-sp_prot-phosphatase

PPP1CA PPP1CC

2.76e-03131142IPR006186
DomainRanBD

RGPD2 RGPD1

2.76e-03131142SM00160
DomainSER_THR_PHOSPHATASE

PPP1CA PPP1CC

2.76e-03131142PS00125
DomainPP2Ac

PPP1CA PPP1CC

2.76e-03131142SM00156
DomainRan_bind_dom

RGPD2 RGPD1

2.76e-03131142IPR000156
DomainProt_kinase_dom

CDK16 TRIO KALRN SPEG STK32A NEK5 NRK FES HCK

3.07e-034891149IPR000719
DomainRasGAP

IQGAP2 NF1

3.20e-03141142SM00323
DomainIMPORTIN_B_NT

IPO4 IPO13

3.20e-03141142PS50166
DomainCNH

VPS39 NRK

3.20e-03141142SM00036
DomainRasGAP_CS

IQGAP2 NF1

3.20e-03141142IPR023152
DomainPROTEIN_KINASE_DOM

CDK16 TRIO KALRN SPEG STK32A NEK5 NRK FES HCK

3.24e-034931149PS50011
DomainSH2

FES SHE HCK VAV1

3.41e-031011144PF00017
DomainTPR_2

TTC3 TTC7B TTC12

3.52e-03501143PF07719
DomainTPR_2

TTC3 TTC7B TTC12

3.52e-03501143IPR013105
DomainRasGAP

IQGAP2 NF1

3.68e-03151142PF00616
DomainRAS_GTPASE_ACTIV_1

IQGAP2 NF1

3.68e-03151142PS00509
DomainIBN_N

IPO4 IPO13

3.68e-03151142PF03810
DomainCNH

VPS39 NRK

3.68e-03151142PF00780
DomainRAS_GTPASE_ACTIV_2

IQGAP2 NF1

3.68e-03151142PS50018
DomainCNH

VPS39 NRK

3.68e-03151142PS50219
DomainCNH_dom

VPS39 NRK

3.68e-03151142IPR001180
DomainIBN_N

IPO4 IPO13

4.19e-03161142SM00913
DomainPH_dom-like

RGPD2 TRIO KALRN RGPD1 ARHGEF11 DOK4 FRMPD3 VAV1

4.61e-034261148IPR011993
DomainSH2

FES SHE HCK VAV1

4.63e-031101144SM00252
DomainHEAT_type_2

IPO4 GCN1

4.73e-03171142IPR021133
DomainImportin-beta_N

IPO4 IPO13

4.73e-03171142IPR001494
DomainSH2

FES SHE HCK VAV1

4.78e-031111144PS50001
DomainSH2

FES SHE HCK VAV1

4.93e-031121144IPR000980
Domain-

FES SHE HCK VAV1

4.93e-0311211443.30.505.10
DomainRasGAP_dom

IQGAP2 NF1

5.30e-03181142IPR001936
DomainHEAT

IPO4 IPO13 GCN1

5.35e-03581143IPR000357
DomainKinase-like_dom

CDK16 TRIO KALRN SPEG STK32A NEK5 NRK FES HCK

5.98e-035421149IPR011009
Pubmed

Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.

LRRC37A3 LRRC37A2 LRRC37A

1.52e-074118322419166
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RGPD2 TRIO IQGAP2 KALRN RGPD1 IPO4 ARHGEF11 TTC3 PPP1CA PPP1CC NF1 GIGYF2 FRMPD3 UNC79 CUX1 RAI1

1.76e-079631181628671696
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ATMIN USP34 ARSJ TRIO KALRN VPS39 MTHFD1L SPEG MAML1 ARHGEF11 TTC3 DHX30 FZR1 DOK4 KCNQ2 GCN1 RAI1

2.08e-0711051181735748872
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

SERPINA3 TRIO KALRN TTC3 RSU1 FAF1 PPP1CC GSE1 ITGB1BP2 ANKRD1 COL14A1

1.10e-064971181123414517
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

USP34 MTHFD1L IPO4 DHX30 PPP1CA PPP1CC NF1 UTP4 ACIN1 GIGYF2 GCN1 RAI1

2.42e-066531181222586326
Pubmed

Evolutionary dynamism of the primate LRRC37 gene family.

LRRC37A3 LRRC37A2 LRRC37A

4.49e-0610118323064749
Pubmed

Cux1 and Cux2 selectively target basal and apical dendritic compartments of layer II-III cortical neurons.

CUX2 CUX1

1.14e-052118225059644
Pubmed

Cux-1 and Cux-2 control the development of Reelin expressing cortical interneurons.

CUX2 CUX1

1.14e-052118218327765
Pubmed

A unique variant of a homeobox gene related to Drosophila cut is expressed in mouse testis.

CUX2 CUX1

1.14e-05211828879483
Pubmed

Bacterial LPS and IFN-gamma trigger the tyrosine phosphorylation of vav in macrophages: evidence for involvement of the hck tyrosine kinase.

HCK VAV1

1.14e-05211829400828
Pubmed

CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate.

CUX2 CUX1

1.14e-052118235581205
Pubmed

PP-1α and PP-1γ display antagonism and differential roles in tumorigenicity of lung cancer cells.

PPP1CA PPP1CC

1.14e-052118223176181
Pubmed

NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control.

RGS9 NF1

1.14e-052118231600280
Pubmed

Expression of a cut-related homeobox gene in developing and polycystic mouse kidney.

CUX2 CUX1

1.14e-05211828840273
Pubmed

Cux1 Enables Interhemispheric Connections of Layer II/III Neurons by Regulating Kv1-Dependent Firing.

CUX2 CUX1

1.14e-052118226804994
Pubmed

NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum.

RGS9 NF1

1.14e-052118227773571
Pubmed

Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene.

PPP1CA PPP1CC

1.14e-05211829882500
Pubmed

Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP.

TRIO KALRN

1.14e-052118226858404
Pubmed

Mlh1 deficiency accelerates myeloid leukemogenesis in neurofibromatosis 1 (Nf1) heterozygous mice.

NF1 MLH1

1.14e-052118212881715
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

IQGAP2 VPS39 IPO4 DHX30 GTPBP2 NF1 CEP78 GCN1

1.22e-05313118838270169
Pubmed

Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.

TRIO KALRN

3.42e-053118231801062
Pubmed

The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis.

LBP NR1H2

3.42e-053118224671012
Pubmed

Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network.

PPP1CA PPP1CC

3.42e-053118219074462
Pubmed

Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target.

ARL4C NR1H2

3.42e-053118221187453
Pubmed

1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.

PPP1CA PPP1CC

3.42e-053118225073485
Pubmed

Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.

PPP1CA PPP1CC

3.42e-053118221712997
Pubmed

NOM1 targets protein phosphatase I to the nucleolus.

PPP1CA PPP1CC

3.42e-053118217965019
Pubmed

The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.

PPP1CA PPP1CC

3.42e-053118212138106
Pubmed

Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization.

PPP1CA PPP1CC

3.42e-05311827857673
Pubmed

Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.

PPP1CA PPP1CC

3.42e-053118211739654
Pubmed

Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1.

PPP1CA PPP1CC

3.42e-053118211588169
Pubmed

Characterization of protein phosphatases in mouse oocytes.

PPP1CA PPP1CC

3.42e-05311829882488
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

CDK16 RGPD2 RGPD1 BSDC1 TUBGCP5 CWC22 DSN1 DHX30 PPP1CA PPP1CC FZR1 CEP78 CCDC15 GCN1

3.86e-0511551181420360068
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

LRRC37A3 RGPD1 MAML1 DSN1 NF1 GSE1 SYPL1 CUX1 RAI1 DNAH11

6.64e-056381181031182584
Pubmed

Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.

PPP1CA PPP1CC

6.82e-054118223499489
Pubmed

Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein.

PPP1CA PPP1CC

6.82e-054118216131488
Pubmed

Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.

PPP1CA PPP1CC

6.82e-054118210194355
Pubmed

Biochemical characterization of the mammalian Cux2 protein.

CUX2 CUX1

6.82e-054118215656993
Pubmed

NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1.

PPP1CA PPP1CC

6.82e-054118210880350
Pubmed

Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis.

PPP1CA PPP1CC

6.82e-054118215226296
Pubmed

Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1.

PPP1CA PPP1CC

6.82e-054118222768081
Pubmed

Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif.

PPP1CA PPP1CC

6.82e-054118210807923
Pubmed

Mouse mutagenesis identifies novel roles for left-right patterning genes in pulmonary, craniofacial, ocular, and limb development.

ATMIN DNAH11

6.82e-054118219235720
Pubmed

Nuclear protein phosphatase-1 regulates HIV-1 transcription.

PPP1CA PPP1CC

6.82e-054118212788939
Pubmed

Cux1 and Cux2 regulate dendritic branching, spine morphology, and synapses of the upper layer neurons of the cortex.

CUX2 CUX1

6.82e-054118220510857
Pubmed

Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx.

PPP1CA PPP1CC

6.82e-054118223277204
Pubmed

The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits.

PPP1CA PPP1CC

6.82e-054118212016225
Pubmed

Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.

PPP1CA PPP1CC

6.82e-054118212221103
Pubmed

Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.

PPP1CA PPP1CC

6.82e-054118212226088
Pubmed

Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation.

PPP1CA PPP1CC

6.82e-054118217202132
Pubmed

A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand.

PPP1CA PPP1CC

6.82e-054118212036952
Pubmed

N-CoR controls differentiation of neural stem cells into astrocytes.

PPP1CA PPP1CC

6.82e-054118212410313
Pubmed

Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues.

FES HCK

6.82e-05411828955135
Pubmed

Synphilin-1A is a phosphoprotein phosphatase 1-interacting protein and affects PPP1 sorting to subcellular compartments.

PPP1CA PPP1CC

6.82e-054118224902662
Pubmed

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

CDK16 RSU1 DSN1 PPP1CA PPP1CC CCNE2 FES GCN1

7.07e-05401118825852190
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

USP34 SFSWAP IQGAP2 ARL11 MAML1 BSDC1 IPO4 ARL4C GTPBP2 GCN1 CUX1

7.07e-057771181135844135
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

RGPD2 SFSWAP RGPD1 GIGYF2 GCN1 CUX1

9.64e-05215118635973513
Pubmed

Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.

KALRN NPAS3 SGMS1 CCDC15 COL14A1

9.72e-05134118524324551
Pubmed

Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions.

PPP1CA PPP1CC

1.13e-045118223197154
Pubmed

Assembly of high order G alpha q-effector complexes with RGS proteins.

TRIO KALRN

1.13e-045118218936096
Pubmed

Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.

PPP1CA PPP1CC

1.13e-045118219581931
Pubmed

Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.

PPP1CA PPP1CC

1.13e-045118222801782
Pubmed

The heterotrimeric G protein Gβ1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets.

PPP1CA PPP1CC

1.13e-045118228615442
Pubmed

Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220.

PPP1CA PPP1CC

1.13e-045118210209101
Pubmed

A PP1-PP2A phosphatase relay controls mitotic progression.

PPP1CA PPP1CC

1.13e-045118225487150
Pubmed

SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.

PPP1CA PPP1CC

1.13e-045118220424263
Pubmed

Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to Drosophila cut.

CUX2 CUX1

1.13e-04511828798433
Pubmed

Initiation factor 2B activity is regulated by protein phosphatase 1, which is activated by the mitogen-activated protein kinase-dependent pathway in insulin-like growth factor 1-stimulated neuronal cells.

PPP1CA PPP1CC

1.13e-045118212624094
Pubmed

The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.

PPP1CA PPP1CC

1.13e-045118212016208
Pubmed

Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle.

PPP1CA PPP1CC

1.13e-045118211551964
Pubmed

The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype.

CUX2 CUX1

1.13e-04511827910552
Pubmed

The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.

PPP1CA PPP1CC

1.13e-045118217511879
Pubmed

The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.

PPP1CA PPP1CC

1.13e-045118224116158
Pubmed

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.

FES SHE HCK VAV1

1.14e-0473118424728074
Pubmed

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.

MAN1A1 MTHFD1L IPO4 CEP78 NEK5 ALG8 VAV1 RAI1

1.16e-04431118833660365
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

USP34 CIB1 TRIO KALRN VPS39 TTC3 TUBGCP5 FAF1 DHX30 TTC7B CCDC15 KCNQ2 NR1H2 CUX1

1.20e-0412851181435914814
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

RGSL1 LBP TTC3 CEP78 NEK5 STARD9 SYPL1 XRRA1 RXFP1 ANKRD40

1.20e-046861181029987050
Pubmed

Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.

FES SHE HCK VAV1

1.41e-0477118422973453
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

CDK16 IQGAP2 MAML1 IPO4 DHX30 PPP1CA PPP1CC NF1 NEK5 TRAPPC10 IPO13 GIGYF2 COL14A1 GCN1

1.60e-0413211181427173435
Pubmed

MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7.

ARL4C NR1H2

1.70e-046118222673513
Pubmed

Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins.

PPP1CA PPP1CC

1.70e-046118223088536
Pubmed

Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex.

CUX2 CUX1

1.70e-046118215452856
Pubmed

SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1.

PPP1CA PPP1CC

1.70e-046118214640981
Pubmed

Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).

PPP1CA PPP1CC

1.70e-046118225785436
Pubmed

Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.

PPP1CA PPP1CC

1.70e-046118221998301
Pubmed

Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3.

PPP1CA PPP1CC

1.70e-046118218641122
Pubmed

The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling.

AMIGO1 KCNQ2 CUX1

1.76e-0432118331315048
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

LRRN1 TRIO KALRN SPEG AMIGO1

2.36e-04162118525826454
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD2 RGPD1

2.37e-047118221205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD2 RGPD1

2.37e-047118218949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD2 RGPD1

2.37e-047118225187515
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD2 RGPD1

2.37e-04711829037092
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD2 RGPD1

2.37e-04711828603673
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD2 RGPD1

2.37e-047118215710750
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD2 RGPD1

2.37e-047118226632511
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD2 RGPD1

2.37e-047118224403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD2 RGPD1

2.37e-047118223818861
Pubmed

A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.

PPP1CA PPP1CC

2.37e-047118212147701
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD2 RGPD1

2.37e-047118211353387
Pubmed

Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex.

PPP1CA PPP1CC

2.37e-047118210637318
Cytoband5q31

PCDHGA7 PCDHGA5 PCDHB7 SLC4A9

2.38e-0411511945q31
Cytoband16q23.2

ATMIN BCO1

3.61e-0411119216q23.2
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD2 RGPD1 TTC3 TTC7B TTC23 TTC12

8.84e-06115766769
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TRIO KALRN ARHGEF11 VAV1

1.71e-0466764722
GeneFamilyCUT class homeoboxes and pseudogenes

CUX2 CUX1

6.16e-049762527
GeneFamilySH2 domain containing

FES SHE HCK VAV1

8.65e-04101764741
GeneFamilyProtein phosphatase catalytic subunits|EF-hand domain containing

PPP1CA PPP1CC

1.32e-0313762693
GeneFamilyClustered protocadherins

PCDHGA7 PCDHGA5 PCDHB7

2.47e-036476320
GeneFamilyArmadillo repeat containing|Importins

IPO4 IPO13

2.55e-0318762596
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

LRRN1 TRIO KALRN SPEG

4.73e-03161764593
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

ARL11 ARL4C

7.49e-0331762357
CoexpressionGSE9946_IMMATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP

VPS39 PCDHB7 AMIGO1 MYO15B UTP4 GCN1 CUX1

5.05e-061511167M421
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARSJ IQGAP2 INPP4B CEP78 SLC4A9 DNAH11

8.05e-06178118651d2188406f04329311b2efd1108fc36617a860e
ToppCellControl-Fibroblasts-Airway_smooth_muscle|Control / group, cell type (main and fine annotations)

KALRN MTHFD1L SPEG INPP4B COL14A1 ASB2

8.58e-061801186d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ARHGEF11 DSN1 DHX30 DGUOK FES HCK

9.13e-061821186d486b0213bd3cf20965cb4e38e95981c4aaff259
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KALRN TRPM3 NRK KCNQ2 UNC79 DNAH11

9.72e-0618411862cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KALRN TRPM3 NRK KCNQ2 UNC79 DNAH11

9.72e-061841186ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KALRN TRPM3 NRK KCNQ2 UNC79 DNAH11

9.72e-0618411862b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellCOVID-19-kidney-CD-IC-B|kidney / Disease (COVID-19 only), tissue and cell type

ARSJ IQGAP2 INPP4B CEP78 SLC4A9 DNAH11

1.07e-051871186ce05b89860573fe0356102e2998d1ef6d1968034
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KALRN MTHFD1L SPEG INPP4B COL14A1 ASB2

1.43e-051971186bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
ToppCellsevere-unassigned|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LRRN1 IQGAP2 DSN1 DOK4 CCNE2 UBE2W

1.43e-05197118670704b149b2820b8601d2495b7cd9cbe91eda262
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KALRN MTHFD1L SPEG INPP4B COL14A1 ASB2

1.47e-051981186bd42c03e384e64f61b02618cf1a5440033bb04b2
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KALRN MTHFD1L SPEG INPP4B COL14A1 ASB2

1.52e-051991186b1753474152b82a0b811b9878c890a359e14919a
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KALRN MTHFD1L SPEG INPP4B COL14A1 ASB2

1.56e-052001186a66449b22b39dd6987fc2c3ed160d24564234ced
DrugDoxylamine succinate [562-10-7]; Down 200; 10.2uM; MCF7; HT_HG-U133A

CDK16 ZC3H12A TRIO VPS39 BSDC1 DOK4 TTC12 IPO13 NR1H2

8.01e-0719611794819_DN
Diseaseplatelet measurement

IQGAP2 KALRN RSU1 INPP4B GSE1 TRPM3 VAV1 CUX1

3.19e-053151148EFO_0005036
Diseaseimmature platelet fraction

IQGAP2 KALRN TRPM3 VAV1 CUX1

8.27e-051141145EFO_0009187
Diseaseimmature platelet measurement

IQGAP2 KALRN GSE1 TRPM3 VAV1

1.01e-041191145EFO_0803541
DiseaseIntellectual Disability

CDK16 CUX2 TRIO GTPBP2 NF1 TRPM3 ACIN1 RAI1

3.54e-044471148C3714756
DiseaseAutistic behavior

CUX2 TRPM3

4.08e-0481142C0856975
DiseaseNeurodevelopmental Disorders

TRIO DHX30 KCNQ2 GIGYF2

4.73e-04931144C1535926
Diseasealcoholic pancreatitis

NPAS3 DENND10 TTC12 FRMPD3

5.77e-04981144EFO_1002013
Diseasecancer (implicated_via_orthology)

CUX2 VPS25 PPP1CA PPP1CC HCK CUX1

6.24e-042681146DOID:162 (implicated_via_orthology)
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

FES MLH1 COL14A1

7.08e-04451143DOID:3748 (is_implicated_in)
Diseasecoffee consumption measurement

CUX2 NPAS3 LRRC27 FES RAI1

7.21e-041821145EFO_0006781
Diseaseimmature platelet count

IQGAP2 KALRN TRPM3 CUX1

7.75e-041061144EFO_0803544
Diseasemicrophthalmia (implicated_via_orthology)

TRPM3 IPO13

9.52e-04121142DOID:10629 (implicated_via_orthology)
Diseasealcohol and nicotine codependence

RGPD2 RGPD1

1.12e-03131142EFO_0004776
Diseasehematologic cancer (implicated_via_orthology)

CUX2 CUX1

1.12e-03131142DOID:2531 (implicated_via_orthology)
DiseaseDyskinesia, Drug-Induced

PENK RGS9

1.50e-03151142C0013386
DiseaseDyskinesia, Medication-Induced

PENK RGS9

1.50e-03151142C0751088
DiseaseMAJOR AFFECTIVE DISORDER 2

CUX2 KCNQ2

1.94e-03171142C1839839
Diseaseacute pancreatitis

STK32A SCGB3A2

2.17e-03181142EFO_1000652
DiseaseMalignant neoplasm of endometrium

MLH1 CUX1

2.17e-03181142C0007103
DiseaseCarcinoma in situ of endometrium

MLH1 CUX1

2.17e-03181142C0346191
Diseaseplatelet component distribution width

IQGAP2 KALRN RSU1 INPP4B GSE1 TRPM3 MLH1 VAV1 CUX1

2.67e-037551149EFO_0007984
DiseaseSarcosine measurement

PCDHGA7 PCDHGA5

3.55e-03231142EFO_0021668
Diseaseresponse to antiviral drug, cirrhosis of liver

MAN1A1 KCNQ2

3.86e-03241142EFO_0001422, EFO_0010123

Protein segments in the cluster

PeptideGeneStartEntry
AQPLPLKIEELALAK

ACIN1

526

Q9UKV3
EKLAALLPEPLKVIF

AGXT2

151

Q9BYV1
VLNLEALKQKRFPPA

DENND10P1

326

Q6NSW5
KELGVPKDPLLFIQL

SLC4A9

46

Q96Q91
DLSSNKLKNLPLPDL

AMIGO1

191

Q86WK6
ELLNTEAPLKLVNPL

ACTL7B

101

Q9Y614
PLLVIANKQDLPKSL

ARL4C

121

P56559
PEARVLPKDLSQKLL

BSDC1

296

Q9NW68
LKAPDKNVIFSPLSI

SERPINA3

66

P01011
VPTFLKAALENKLPV

ANKRD1

121

Q15327
SQLAPADPLIKAIKD

ASB2

101

Q96Q27
PEDLRKQVAPLLKSF

CUX1

46

P39880
RSDQPLIDPKLLLEK

FAM47DP

326

A6NHR8
SPNLEDFQKRKLLDP

GSDMC

126

Q9BYG8
KVFLNILPPLTNSKE

GTPBP2

386

Q9BX10
KELLAAKALEPSFLP

GSE1

396

Q14687
NIFLEKNAPLRVKIP

ARHGEF11

366

O15085
LQVDALKDAPKVLLP

CCNE2

251

O96020
VQLEPFPEKLLQARK

DGUOK

121

Q16854
LKDPEFNPNLIRTKS

DNAH11

3276

Q96DT5
DNLPQLKKESELPFV

ANKRD40

106

Q6AI12
APLLSTLKINKDLPL

CEP78

56

Q5JTW2
LLKEFPQPKNLLNSV

DHX30

46

Q7L2E3
QKFLLEKPSLLASPE

CUX2

406

O14529
LSLLQEKNPAFKPVL

MTHFD1L

86

Q6UB35
PLQKDKLPENLLSDL

RAI1

416

Q7Z5J4
IPENLPFKLEKSIDN

PCDHGA7

386

Q9Y5G6
LQDPKNLILKPDGSL

RGS9

86

O75916
IPRNLPFKLEKSVDN

PCDHGA5

386

Q9Y5G8
KELLQLSKPELPQDG

PENK

66

P01210
ANKQEAPDALPLLKI

ARL11

121

Q969Q4
ESFPLSLNKELKQEP

MAML1

206

Q92585
NLDVKSLLLPFIKLP

LRRC37A3

1131

O60309
NDKLAEGFPLPLLKR

LBP

441

P18428
NLDVKSLLLPFIKLP

LRRC37A2

1131

A6NM11
NLDVKSLLLPFIKLP

LRRC37A

1131

A6NMS7
KSELPLKLLPLNISQ

ITGB1BP2

106

Q9UKP3
QAPIADILSDPKKLL

NLRP11

211

P59045
NCLPLDNATLPQKLK

ARSJ

151

Q5FYB0
KDNLPFLNSVLKNPV

INPP4B

221

O15327
LPKLNARLKDETLQP

CWC22

596

Q9HCG8
PPLNQLELLRNLKSK

KCNQ2

386

O43526
NSILKRPFLENLIPK

NEK5

251

Q6P3R8
DLIKPLLKTLQEAFP

KALRN

106

O60229
FLNAPLPSIKEIKTD

TUBGCP5

91

Q96RT8
DPQAIKPILKALLDN

GCN1

2586

Q92616
LQKPLLKFVSDQAPR

MYO15B

591

Q96JP2
FLSQPILLELEAPLK

PPP1CA

46

P62136
EFKFLKPIIPNLLPQ

PCDHB7

761

Q9Y5E2
ISKIPFKVLDAPELQ

FZR1

171

Q9UM11
SLKESLPLFKIANPI

ATMIN

361

O43313
SKQPLPKLIDFSAQI

HCK

351

P08631
NKIPSDLLDKEFLPI

GIGYF2

56

Q6Y7W6
FDKRPLSPALNALKQ

CCDC81

411

Q6ZN84
LEKLTLNSPIFDKPL

CDK16

131

Q00536
NNLLLKPLLPDTEYK

COL14A1

791

Q05707
FLPPSLLQVIKEKNL

FRMPD3

341

Q5JV73
QQLDPSPARKLLKLQ

DSN1

326

Q9H410
KLDLLPSSLKLSNEP

ANKMY1

626

Q9P2S6
FNSEAHLLPILPKDK

MAN1A1

631

P33908
QLDPNKSLLEVKLFP

FAF1

626

Q9UNN5
VLNLEALKQKRFPPA

DENND10

326

Q8TCE6
LEKLAEEIPNPSNKL

IPO13

621

O94829
LADNKIPPDTKAALL

IPO4

1031

Q8TEX9
DLLNRFILLKPKPSQ

DOK4

301

Q8TEW6
DDQLVVLFPVQKPKL

PRAP1

56

Q96NZ9
KVPNLKFLDLNKNPI

LRRN1

261

Q6UXK5
LPELTKLEATNNPKL

LRRN1

311

Q6UXK5
LLDLRQKFPPKFVQL

MED6

181

O75586
RSLELNPPQKDLVLK

RGPD1

76

P0DJD0
NPPQKDLVLKIAELL

RGPD1

81

P0DJD0
NLDPVDKFSKLRPLI

PGBD3

236

Q8N328
LPPDLKAKFLQEARI

FES

596

P07332
PDELLHLLKLKVFPT

NRK

1391

Q7Z2Y5
FEILPPDIGKLTKLQ

RSU1

146

Q15404
LNPLKEPLGFIKVLE

SYPL1

26

Q16563
IIDKSLPLPNDKTLL

UTP4

606

Q969X6
IIQKLFLNSDIPPKL

RGSL1

921

A5PLK6
KAALFLQTLKNPLPE

SFSWAP

686

Q12872
AFLINKVPLPVDKLA

SCGB3A2

21

Q96PL1
ELPPNLKAALNIEKE

LRRC27

286

Q9C0I9
QLEPNNFPKKPKLDL

PUS7L

61

Q9H0K6
NFPKKPKLDLQNLSL

PUS7L

66

Q9H0K6
LELNPPQKDLVLKIA

RGPD2

86

P0DJD1
NTLLALKKPEAQLPA

IQGAP2

321

Q13576
SVFKLEENPKPALIL

MARCOL

26

A0A1B0GUY1
EQVFALRLQDKKLPP

NR1H2

436

P55055
KLLPLPAAITSQLDK

NPAS3

76

Q8IXF0
KQLSPNLDLDPLELI

RHOBTB1

546

O94844
SPQKQLSLLPNKDLF

STARD9

4281

Q9P2P6
LLKKLLEPNPDQRFS

STK32A

256

Q8WU08
QKLDAFLQPLSKPLS

MLH1

391

P40692
TDPQKLPFLLILDAK

BCO1

481

Q9HAY6
LKLKFLDPNNIPKAS

ALG8

301

Q9BVK2
LPLALNPLKSKDVLA

CCDC15

16

Q0P6D6
EQILSLPELKANPFK

CIB1

56

Q99828
KPHLPTKEFLLSLLQ

CLN5

296

O75503
ESPLFNNVKLQRKLP

VPS25

56

Q9BRG1
PSLDNFLRKKPLTLE

ZC3H12A

286

Q5D1E8
IKPDNLLLAPDNALK

SPEG

3086

Q15772
LPPSILSLEFKNKDD

TRPM3

806

Q9HCF6
LKPLQRFLKPQDIEI

VAV1

221

P15498
KLNILPSKRDLAAEP

ZBTB18

166

Q99592
SPLTLPADLKNILEK

TTC3

456

P53804
IALTKLQPLLNKDSP

NF1

2296

P21359
PPLIFKDLKELSQLN

RXFP1

311

Q9HBX9
LINLTQEDFKKPPLC

SGMS1

36

Q86VZ5
VALLNPIENPDLKLA

STIMATE

181

Q86TL2
FQDLKLPPIKELNEE

nan

496

Q6ZUG5
FLSQPILLELEAPLK

PPP1CC

46

P36873
LKPDDATIPLLAAKL

TTC7B

426

Q86TV6
KNLLETLSKPDQIPL

TTC12

246

Q9H892
KLLQTALFQPPREKL

TTC23

31

Q5W5X9
KRLQKELLALQNDPP

UBE2W

6

Q96B02
GLDKLEEKLPFLQQP

PLIN5

96

Q00G26
STLLKFLPDAQALKP

USP34

1701

Q70CQ2
LFLLPSLKDRQQPKC

USP34

1821

Q70CQ2
ELLPKEGNKALLTFP

TRAPPC10

71

P48553
SKDPLVKALQLLDSP

SHE

246

Q5VZ18
PPKKTRAQLLDDIFI

XRRA1

681

Q6P2D8
DSIKPLLKILQESFP

TRIO

136

O75962
TEKDLIPKLFQVLAP

MRPL17

81

Q9NRX2
PIKLELLEPKANLQA

VPS39

756

Q96JC1
LLQALKLKSPLPDTN

UNC79

2266

Q9P2D8