Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	ADGRG7 HCAR3 XCR1 HCAR2 DRD3 OR4K1 RXFP2 ADGRL1 PTAFR ADGRL2 OR4K15 PTGDR2 OR1J2 GNRHR2	2.73e-06	884	72	14	GO:0004930
GeneOntologyMolecularFunction	latrotoxin receptor activity	ADGRL1 ADGRL2	1.28e-05	2	72	2	GO:0016524
GeneOntologyMolecularFunction	nicotinic acid receptor activity	HCAR3 HCAR2	1.28e-05	2	72	2	GO:0070553
GeneOntologyMolecularFunction	protein-hormone receptor activity	RXFP2 EXTL3 GNRHR2	6.59e-05	22	72	3	GO:0016500
GeneOntologyMolecularFunction	nucleotide receptor activity	HCAR3 HCAR2 PTAFR	6.59e-05	22	72	3	GO:0016502
GeneOntologyMolecularFunction	purinergic nucleotide receptor activity	HCAR3 HCAR2 PTAFR	6.59e-05	22	72	3	GO:0001614
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	ADGRG7 HCAR3 XCR1 HCAR2 DRD3 OR4K1 RXFP2 ADGRL1 PTAFR ADGRL2 OR4K15 PTGDR2 OR1J2 GNRHR2	2.93e-04	1353	72	14	GO:0004888
Domain	HCAR2/3_rcpt	HCAR3 HCAR2	1.35e-05	2	69	2	IPR028017
Domain	7tm_1	HCAR3 XCR1 HCAR2 DRD3 OR4K1 RXFP2 PTAFR OR4K15 PTGDR2 OR1J2 GNRHR2	3.52e-05	677	69	11	PF00001
Domain	G_PROTEIN_RECEP_F1_1	HCAR3 XCR1 HCAR2 DRD3 OR4K1 RXFP2 PTAFR OR4K15 PTGDR2 OR1J2 GNRHR2	3.92e-05	685	69	11	PS00237
Domain	Latrophilin	ADGRL1 ADGRL2	4.03e-05	3	69	2	PF02354
Domain	GPCR_2_latrophilin_rcpt_C	ADGRL1 ADGRL2	4.03e-05	3	69	2	IPR003334
Domain	G_PROTEIN_RECEP_F1_2	HCAR3 XCR1 HCAR2 DRD3 OR4K1 RXFP2 PTAFR OR4K15 PTGDR2 OR1J2 GNRHR2	4.24e-05	691	69	11	PS50262
Domain	GPCR_Rhodpsn	HCAR3 XCR1 HCAR2 DRD3 OR4K1 RXFP2 PTAFR OR4K15 PTGDR2 OR1J2 GNRHR2	4.29e-05	692	69	11	IPR000276
Domain	GPCR_2_latrophilin	ADGRL1 ADGRL2	1.34e-04	5	69	2	IPR003924
Domain	Lectin_gal-bd_dom	ADGRL1 ADGRL2	1.34e-04	5	69	2	IPR000922
Domain	Gal_Lectin	ADGRL1 ADGRL2	1.34e-04	5	69	2	PF02140
Domain	SUEL_LECTIN	ADGRL1 ADGRL2	1.34e-04	5	69	2	PS50228
Domain	GPCR_Rhodpsn_7TM	HCAR3 XCR1 HCAR2 DRD3 OR4K1 RXFP2 PTAFR OR4K15 PTGDR2 OR1J2	1.66e-04	670	69	10	IPR017452
Domain	GPS	ADGRG7 ADGRL1 ADGRL2	2.66e-04	34	69	3	SM00303
Domain	GPS	ADGRG7 ADGRL1 ADGRL2	2.90e-04	35	69	3	PF01825
Domain	GPS	ADGRG7 ADGRL1 ADGRL2	3.16e-04	36	69	3	PS50221
Domain	GPS	ADGRG7 ADGRL1 ADGRL2	3.43e-04	37	69	3	IPR000203
Domain	GAIN_dom_N	ADGRL1 ADGRL2	7.24e-04	11	69	2	IPR032471
Domain	GAIN	ADGRL1 ADGRL2	7.24e-04	11	69	2	PF16489
Domain	G_PROTEIN_RECEP_F2_2	ADGRG7 ADGRL1 ADGRL2	8.35e-04	50	69	3	PS00650
Domain	7tm_2	ADGRG7 ADGRL1 ADGRL2	8.35e-04	50	69	3	PF00002
Domain	OLF	ADGRL1 ADGRL2	1.02e-03	13	69	2	PS51132
Domain	Olfac-like_dom	ADGRL1 ADGRL2	1.02e-03	13	69	2	IPR003112
Domain	OLF	ADGRL1 ADGRL2	1.02e-03	13	69	2	SM00284
Domain	OLF	ADGRL1 ADGRL2	1.02e-03	13	69	2	PF02191
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DNAH6	1.19e-03	14	69	2	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DNAH6	1.19e-03	14	69	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DNAH6	1.19e-03	14	69	2	IPR013602
Domain	DHC_N2	DNAH10 DNAH6	1.19e-03	14	69	2	PF08393
Domain	MT	DNAH10 DNAH6	1.19e-03	14	69	2	PF12777
Domain	AAA_8	DNAH10 DNAH6	1.19e-03	14	69	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH10 DNAH6	1.19e-03	14	69	2	IPR011704
Domain	AAA_5	DNAH10 DNAH6	1.19e-03	14	69	2	PF07728
Domain	DHC_fam	DNAH10 DNAH6	1.37e-03	15	69	2	IPR026983
Domain	Dynein_heavy_dom	DNAH10 DNAH6	1.37e-03	15	69	2	IPR004273
Domain	Dynein_heavy	DNAH10 DNAH6	1.37e-03	15	69	2	PF03028
Domain	GPCR_2_secretin-like	ADGRG7 ADGRL1 ADGRL2	1.42e-03	60	69	3	IPR000832
Domain	GPCR_2-like	ADGRG7 ADGRL1 ADGRL2	1.42e-03	60	69	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	ADGRG7 ADGRL1 ADGRL2	1.49e-03	61	69	3	PS50261
Domain	IQ	MYO7A IQCF3 IQCF6	2.30e-03	71	69	3	PF00612
Domain	Spectrin	SPTB MCF2L	3.24e-03	23	69	2	PF00435
Domain	HormR	ADGRL1 ADGRL2	3.82e-03	25	69	2	SM00008
Domain	IQ_motif_EF-hand-BS	MYO7A IQCF3 IQCF6	4.51e-03	90	69	3	IPR000048
Domain	HRM	ADGRL1 ADGRL2	4.78e-03	28	69	2	PF02793
Domain	IQ	MYO7A IQCF3 IQCF6	4.94e-03	93	69	3	PS50096
Domain	Spectrin_repeat	SPTB MCF2L	5.12e-03	29	69	2	IPR002017
Domain	Spectrin/alpha-actinin	SPTB MCF2L	6.21e-03	32	69	2	IPR018159
Domain	SPEC	SPTB MCF2L	6.21e-03	32	69	2	SM00150
Domain	GPCR_2_secretin-like_CS	ADGRL1 ADGRL2	6.99e-03	34	69	2	IPR017983
Pathway	WP_GPCRS_NONODORANT	HCAR3 XCR1 HCAR2 DRD3 RXFP2 ADGRL1 PTAFR ADGRL2	1.07e-05	266	57	8	MM15843
Pubmed	Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization.	HCAR3 HCAR2	4.35e-06	2	73	2	28186140
Pubmed	The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation.	HCAR3 HCAR2	4.35e-06	2	73	2	30154797
Pubmed	The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.	HCAR3 HCAR2	4.35e-06	2	73	2	24371223
Pubmed	High dietary niacin may increase prostaglandin formation but does not increase tumor formation in ApcMin/+ mice.	HCAR3 HCAR2	4.35e-06	2	73	2	21774590
Pubmed	The role of HCA2 (GPR109A) in regulating macrophage function.	HCAR3 HCAR2	4.35e-06	2	73	2	23882124
Pubmed	Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.	HCAR3 HCAR2	4.35e-06	2	73	2	36891315
Pubmed	GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes.	HCAR3 HCAR2	4.35e-06	2	73	2	36208084
Pubmed	Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a.	HCAR3 HCAR2	4.35e-06	2	73	2	38007572
Pubmed	The role of the C-terminus of the human hydroxycarboxylic acid receptors 2 and 3 in G protein activation using Gα-engineered yeast cells.	HCAR3 HCAR2	4.35e-06	2	73	2	26656756
Pubmed	Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.	HCAR3 HCAR2	4.35e-06	2	73	2	37597514
Pubmed	The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism.	HCAR3 HCAR2	4.35e-06	2	73	2	33924461
Pubmed	Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE.	HCAR3 HCAR2	4.35e-06	2	73	2	24691444
Pubmed	Ketone Body 3-Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a-Mediated Calcium Influx.	HCAR3 HCAR2	4.35e-06	2	73	2	33977048
Pubmed	Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms.	HCAR3 HCAR2	4.35e-06	2	73	2	31347703
Pubmed	PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily.	HCAR3 HCAR2	4.35e-06	2	73	2	11745392
Pubmed	Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis.	HCAR3 HCAR2	4.35e-06	2	73	2	30659164
Pubmed	Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets.	HCAR3 HCAR2	4.35e-06	2	73	2	25622782
Pubmed	GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice.	HCAR3 HCAR2	4.35e-06	2	73	2	33420329
Pubmed	Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium.	HCAR3 HCAR2	4.35e-06	2	73	2	19223991
Pubmed	Molecular identification of nicotinic acid receptor.	HCAR3 HCAR2	4.35e-06	2	73	2	12646212
Pubmed	PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.	HCAR3 HCAR2	4.35e-06	2	73	2	12563315
Pubmed	Identification of predicted human outer dynein arm genes: candidates for primary ciliary dyskinesia genes.	DNAH10 DNAH6	4.35e-06	2	73	2	15937072
Pubmed	Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.	HCAR3 HCAR2	4.35e-06	2	73	2	23967184
Pubmed	Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice.	HCAR3 HCAR2	4.35e-06	2	73	2	26371038
Pubmed	Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease.	HCAR3 HCAR2	4.35e-06	2	73	2	34653248
Pubmed	Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G).	HCAR3 HCAR2	4.35e-06	2	73	2	19136666
Pubmed	G Protein-Coupled Receptor 109A Maintains the Intestinal Integrity and Protects Against ETEC Mucosal Infection by Promoting IgA Secretion.	HCAR3 HCAR2	4.35e-06	2	73	2	33488584
Pubmed	Lactate-induced activation of HCA2 improves survival in mice with sepsis.	HCAR3 HCAR2	4.35e-06	2	73	2	30951370
Pubmed	Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet.	HCAR3 HCAR2	4.35e-06	2	73	2	31858105
Pubmed	Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock.	HCAR3 HCAR2	4.35e-06	2	73	2	30625381
Pubmed	Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice.	RXFP2 INPP4B	4.35e-06	2	73	2	32413098
Pubmed	Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy.	HCAR3 HCAR2	4.35e-06	2	73	2	32068460
Pubmed	The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.	HCAR3 HCAR2	4.35e-06	2	73	2	30657794
Pubmed	Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.	HCAR3 HCAR2	4.35e-06	2	73	2	30085883
Pubmed	Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation.	HCAR3 HCAR2	4.35e-06	2	73	2	21655214
Pubmed	Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.	HCAR3 HCAR2	4.35e-06	2	73	2	34092246
Pubmed	(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.	HCAR3 HCAR2	4.35e-06	2	73	2	15929991
Pubmed	Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.	HCAR3 HCAR2	4.35e-06	2	73	2	36991440
Pubmed	Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages.	HCAR3 HCAR2	4.35e-06	2	73	2	25320346
Pubmed	Molecular identification of high and low affinity receptors for nicotinic acid.	HCAR3 HCAR2	4.35e-06	2	73	2	12522134
Pubmed	Nicotinic acid inhibits glucose-stimulated insulin secretion via the G protein-coupled receptor PUMA-G in murine islet β cells.	HCAR3 HCAR2	4.35e-06	2	73	2	21441844
Pubmed	G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis.	HCAR3 HCAR2	4.35e-06	2	73	2	30271409
Pubmed	Niacin fine-tunes energy homeostasis through canonical GPR109A signaling.	HCAR3 HCAR2	4.35e-06	2	73	2	30596513
Pubmed	The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.	HCAR3 HCAR2	4.35e-06	2	73	2	35320002
Pubmed	GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing.	HCAR3 HCAR2	4.35e-06	2	73	2	16322797
Pubmed	BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease.	HCAR3 HCAR2	4.35e-06	2	73	2	31914599
Pubmed	Nicotinic acid receptor agonists.	HCAR3 HCAR2	4.35e-06	2	73	2	18983141
Pubmed	Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms.	HCAR3 HCAR2	4.35e-06	2	73	2	31366236
Pubmed	Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes.	HCAR3 HCAR2	4.35e-06	2	73	2	20655299
Pubmed	Evidence for constitutive dimerization of niacin receptor subtypes.	HCAR3 HCAR2	4.35e-06	2	73	2	20380810
Pubmed	GPR109A Expression in the Murine Min6 Pancreatic Beta Cell Line, and Its Relation with Glucose Metabolism and Inflammation.	HCAR3 HCAR2	4.35e-06	2	73	2	26116596
Pubmed	Expression and activation of the ketone body receptor HCAR2/GPR109A promotes preservation of retinal endothelial cell barrier function.	HCAR3 HCAR2	4.35e-06	2	73	2	35649469
Pubmed	GPR109A expressed on medullary thymic epithelial cells affects thymic Treg development.	HCAR3 HCAR2	4.35e-06	2	73	2	37595951
Pubmed	The hypophagic response to heat stress is not mediated by GPR109A or peripheral β-OH butyrate.	HCAR3 HCAR2	4.35e-06	2	73	2	26936786
Pubmed	Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response.	HCAR3 HCAR2	4.35e-06	2	73	2	34084164
Pubmed	GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice.	HCAR3 HCAR2	4.35e-06	2	73	2	35489706
Pubmed	Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis.	HCAR3 HCAR2	4.35e-06	2	73	2	19561068
Pubmed	A family of heptahelical receptors with adhesion-like domains: a marriage between two super families.	ADGRL1 ADGRL2	1.30e-05	3	73	2	10994649
Pubmed	Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth.	HCAR3 HCAR2	1.30e-05	3	73	2	23579073
Pubmed	Short-chain fatty acids directly exert anti-inflammatory responses in podocytes and tubular epithelial cells exposed to high glucose.	HCAR3 HCAR2	1.30e-05	3	73	2	37215085
Pubmed	Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8.	HCAR3 HCAR2	1.30e-05	3	73	2	20033346
Pubmed	The multiple actions of black widow spider toxins and their selective use in neurosecretion studies.	ADGRL1 ADGRL2	1.30e-05	3	73	2	15066411
Pubmed	Niacin stimulates adiponectin secretion through the GPR109A receptor.	HCAR3 HCAR2	1.30e-05	3	73	2	19141678
Pubmed	International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B).	HCAR3 HCAR2	1.30e-05	3	73	2	21454438
Pubmed	Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.	HCAR3 HCAR2	1.30e-05	3	73	2	20664170
Pubmed	Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.	HCAR3 HCAR2	1.30e-05	3	73	2	24226773
Pubmed	Activation of microglial GPR109A alleviates thermal hyperalgesia in female lupus mice by suppressing IL-18 and glutamatergic synaptic activity.	HCAR3 HCAR2	1.30e-05	3	73	2	34919284
Pubmed	Induction of the cystine/glutamate exchanger SLC7A11 in retinal pigment epithelial cells by the antipsoriatic drug monomethylfumarate.	HCAR3 HCAR2	1.30e-05	3	73	2	23404113
Pubmed	Niacin receptor GPR109A inhibits insulin secretion and is down-regulated in type 2 diabetic islet beta-cells.	HCAR3 HCAR2	1.30e-05	3	73	2	27570060
Pubmed	The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages.	HCAR3 HCAR2	1.30e-05	3	73	2	24845831
Pubmed	Oral Dimethyl Fumarate Targets HCA2-Expressing Skin Cells in the Imiquimod Mouse Model.	HCAR3 HCAR2	1.30e-05	3	73	2	35189149
Pubmed	The Butyrate-Producing Bacterium Clostridium butyricum Suppresses Clostridioides difficile Infection via Neutrophil- and Antimicrobial Cytokine-Dependent but GPR43/109a-Independent Mechanisms.	HCAR3 HCAR2	1.30e-05	3	73	2	33597149
Pubmed	Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells.	HCAR3 HCAR2	1.30e-05	3	73	2	17008386
Pubmed	Effects of high fat diet on GPR109A and GPR81 gene expression.	HCAR3 HCAR2	1.30e-05	3	73	2	22842580
Pubmed	Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression.	HCAR3 HCAR2	1.30e-05	3	73	2	22914621
Pubmed	Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide.	HCAR3 HCAR2	1.30e-05	3	73	2	31710686
Pubmed	Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease.	HCAR3 HCAR2	1.30e-05	3	73	2	32093510
Pubmed	Rare and potentially pathogenic variants in hydroxycarboxylic acid receptor genes identified in breast cancer cases.	HCAR3 HCAR2	1.30e-05	3	73	2	34852802
Pubmed	Dietary Fiber Protects against Diabetic Nephropathy through Short-Chain Fatty Acid-Mediated Activation of G Protein-Coupled Receptors GPR43 and GPR109A.	HCAR3 HCAR2	1.30e-05	3	73	2	32358041
Pubmed	Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells.	HCAR3 HCAR2	1.30e-05	3	73	2	21317532
Pubmed	alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.	ADGRL1 ADGRL2	1.30e-05	3	73	2	11520923
Pubmed	Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways.	HCAR3 HCAR2	2.60e-05	4	73	2	27332875
Pubmed	Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation.	HCAR3 HCAR2	2.60e-05	4	73	2	29514953
Pubmed	Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.	HCAR3 HCAR2	2.60e-05	4	73	2	24412617
Pubmed	The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.	HCAR3 HCAR2	2.60e-05	4	73	2	25686106
Pubmed	Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.	ARFGEF2 FKBP2	2.60e-05	4	73	2	12606707
Pubmed	Clostridium butyricum upregulates GPR109A/AMPK/PGC-1α and ameliorates acute pancreatitis-associated intestinal barrier injury in mice.	HCAR3 HCAR2	2.60e-05	4	73	2	38761195
Pubmed	Niacin activates the PI3K/Akt cascade via PKC- and EGFR-transactivation-dependent pathways through hydroxyl-carboxylic acid receptor 2.	HCAR3 HCAR2	2.60e-05	4	73	2	25375133
Pubmed	TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.	PIWIL4 TASOR2	2.60e-05	4	73	2	32719317
Pubmed	Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81).	HCAR3 HCAR2	2.60e-05	4	73	2	19633298
Pubmed	Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes.	DNAH10 DNAH6	2.60e-05	4	73	2	11175280
Pubmed	The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.	ADGRG7 ADGRL1 ADGRL2	3.12e-05	29	73	3	15203201
Pubmed	Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.	HCAR3 HCAR2	4.33e-05	5	73	2	25828455
Pubmed	C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line.	PIWIL4 SPOCD1	4.33e-05	5	73	2	38359823
Pubmed	Two-factor authentication underpins the precision of the piRNA pathway.	PIWIL4 SPOCD1	4.33e-05	5	73	2	39294378
Pubmed	GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.	HCAR3 HCAR2	4.33e-05	5	73	2	22427566
Pubmed	Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81.	HCAR3 HCAR2	4.33e-05	5	73	2	19047060
Pubmed	β-Hydroxybutyrate suppresses colorectal cancer.	HCAR3 HCAR2	4.33e-05	5	73	2	35477756
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	ADGRG7 ADGRL1 ADGRL2	4.63e-05	33	73	3	25713288
Pubmed	Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.	HCAR3 HCAR2	6.48e-05	6	73	2	19502010
Cytoband	12q24.31	HCAR3 HCAR2 DNAH10	2.90e-04	80	73	3	12q24.31
Cytoband	3p21.2	IQCF3 IQCF6	4.19e-04	19	73	2	3p21.2
GeneFamily	Hydroxy-carboxylic acid receptors	HCAR3 HCAR2	2.52e-05	3	53	2	200
GeneFamily	Adhesion G protein-coupled receptors, subfamily L	ADGRL1 ADGRL2	5.04e-05	4	53	2	918
GeneFamily	Dyneins, axonemal	DNAH10 DNAH6	1.11e-03	17	53	2	536
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGW PIGO	1.71e-03	21	53	2	680
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	MYO7A ARFGEF2	3.25e-03	29	53	2	396
Coexpression	DCA_UP.V1_DN	RNPEPL1 NXF2 SLC35F6 STARD3 NR5A1 ATP10D	1.12e-05	185	71	6	M2760
Coexpression	BROWNE_HCMV_INFECTION_14HR_DN	ASL SPTB SPAG9 REV3L ADGRL2 MAP2K5 INPP4B	1.37e-05	290	71	7	M13251
Computational	Genes in the cancer module 289.	HCAR3 DRD3 ADGRL1 PTAFR ADGRL2	6.97e-05	124	38	5	MODULE_289
Computational	GPCR signaling pathways (immune and neuro).	HCAR3 DRD3 ADGRL1 PTAFR	2.73e-04	90	38	4	MODULE_375
Disease	Hyperphosphatasia-intellectual disability syndrome	PIGW PIGO	8.03e-05	6	69	2	cv:C1855923
Disease	Hyperphosphatasia with Mental Retardation	PIGW PIGO	1.12e-04	7	69	2	C1855923
Disease	Disorder of amino acid metabolism	ASL DBT	1.50e-04	8	69	2	cv:C0002514
Disease	HDL cholesterol change measurement, physical activity	HCAR3 HCAR2 STARD3	4.19e-04	62	69	3	EFO_0003940, EFO_0007805
Disease	Body Weight	PCSK1 MAP2K5	5.55e-04	15	69	2	C0005910
Disease	bilirubin measurement	UBR1 PIEZO1 SPTB REV3L ADGRL2 ARMC6	5.90e-04	442	69	6	EFO_0004570
Disease	Infiltrating duct carcinoma of female breast	SMG1 PKN1	1.10e-03	21	69	2	C3165106
Disease	visual epilepsy (biomarker_via_orthology)	PCSK1 DRD3 WFS1	1.24e-03	90	69	3	DOID:11832 (biomarker_via_orthology)
Disease	attention deficit hyperactivity disorder (implicated_via_orthology)	ADGRL1 ADGRL2	1.96e-03	28	69	2	DOID:1094 (implicated_via_orthology)
Disease	corpus callosum central volume measurement	SLC9A2 PIGO	1.96e-03	28	69	2	EFO_0010296
Disease	Oral ulcer	HCAR3 XCR1 HCAR2	2.04e-03	107	69	3	HP_0000155
Disease	Autosomal dominant nonsyndromic hearing loss	MYO7A WFS1	2.10e-03	29	69	2	cv:C5779548

Protein segments in the cluster

Peptide	Gene	Start	Entry
VQLWAICMLRVALAT	CALR3	6	Q96L12
MARLAAVLWNLCVTA	ADGRL1	1	O94910
TDVVREACWALRVMT	ARMC6	236	Q6NXE6
RWMVIQTLTRICADA	ARFGEF2	496	Q9Y6D5
CRMRSLWFIIVISFL	ADGRL2	6	O95490
MASCRAWNLRVLVAV	ADGRG7	1	Q96K78
RRANTDVLWCVMLLV	ATP10D	316	Q9P241
RIRALRWVTPQMLCV	RABGEF1	241	Q9UJ41
VRITALMVSCNRLWV	SPAG9	1146	O60271
MLRTWSRNAGKLICV	DBT	6	P11182
MREELCVFLVAVSWI	OR1J2	136	Q8NGS2
LSCSWTLQVERLAVM	MYLK	496	Q15746
MRLSWFRVLTVLSIC	FKBP2	1	P26885
FCSARIIWSLRQRQM	HCAR2	206	Q8TDS4
QVVTDLRLWMRQTCS	ASL	116	P04424
VEIMWLAATICRKLN	INPP4B	821	O15327
ARCLTDMRWLRNQVI	RCE1	156	Q9Y256
SMWVCRALEERRSQQ	MAP2K5	431	Q13163
MNRRLCVIFVSISWA	OR4K1	136	Q8NGD4
MSRRVCVVLVLISWF	OR4K15	136	Q8NH41
ALQMTTDRRWIHVIC	KDM4B	806	O94953
RTLLVAALRAWMIQC	IQCF3	51	P0C7M6
MVRRTLLQAALRAWV	IQCF6	1	A8MYZ5
VVGCRMRQTVVTTWV	PTGDR2	56	Q9Y5Y4
RVQNRVKSMLLCLAW	OOEP	101	A6NGQ2
ILTVSQIMWCRDLTE	DNAH6	1321	Q9C0G6
LRTMSCSDKILRWNV	ADAR	1031	P55265
GQTCMLRWSNRIRLT	EXTL3	16	O43909
CARSWVTALQLMERN	MAN2C1	276	Q9NTJ4
RWLCQRTAIESFALM	MCF2L	226	O15068
WIVLREPICISERQM	CA7	211	P43166
LWMVLQRSLVTVRRD	EXOC3	191	O60645
MAARCSTRWLLVVVG	DNAJA3	1	Q96EY1
TVAQMVRVWRNECLR	DNAH10	2676	Q8IVF4
VLRWRSCAMLVVNFS	SLC22A11	341	Q9NSA0
SCVIMQNWARIEARL	SART3	471	Q15020
TLCWSRFTQIRAELM	PRAMEF26	331	H0Y7S4
SNLTRIWAMCIRLLS	CPT1B	146	Q92523
SCRRVALMITAVWVL	DRD3	146	P35462
LSSILVDVWCQTERM	NXF2	481	Q9GZY0
NMLVAICRHSWRVVA	MROH5	191	Q6ZUA9
RKTRTALWCALQMTL	MEIOC	896	A2RUB1
SMNAEIRIRWLQIVV	RNPEPL1	596	Q9HAU8
QTFISIVDWARRCMV	NR5A1	271	Q13285
VKRRALWMVCTVLAV	PTAFR	226	P25105
FCSARIIWSLRQRQM	HCAR3	206	P49019
TVQWLAVDIACRTLM	GNRHR2	16	Q96P88
QTCQDWLTRIRLSIM	SMG1	1021	Q96Q15
ITRWFSRCILQRTMT	PIWIL4	646	Q7Z3Z4
RQTSVILICIWMAGF	RXFP2	536	Q8WXD0
RQMNIDVATWVRLLR	PKN1	506	Q16512
QWMVVRNCSSFLIKR	RPL28	6	P46779
RMVLWNKTVTACQIL	STARD3	306	Q14849
RRMANLAFCIWIVAS	PIGW	366	Q7Z7B1
WRMLTDLRAVNAVIQ	ERVK-9	1006	P63128
PTLRCRVLVTMAVWV	XCR1	141	P46094
RITLNLWRIMRNEVA	REV3L	2461	O60673
CLMWRALGVFVLTQV	SLC9A2	401	Q9UBY0
TVVRSMQEVLWTRLR	SPOCD1	611	Q6ZMY3
RCLVLVAQVVAEMWR	UBR1	651	Q8IWV7
CEWMIQVARDRTLSL	STH	36	Q8IWL8
RWERLRMLLEVCQFS	SPTB	2001	P11277
TRMVLDSLRTVVIWA	SLC35F6	291	Q8N357
FCVVMWRFLEVISRV	XKR3	236	Q5GH77
CWMASRFSRVVLVLI	PIGO	61	Q8TEQ8
IVQDRMLCDIALWST	TASOR2	26	Q5VWN6
CLIWTVRSRHQLAML	PIEZO1	451	Q92508
WNRSTLQCIRTMTCE	WDR3	441	Q9UNX4
VSLCISWRRRVGTQM	TRANK1	2686	O15050
AILLTRWARCKQSEM	TSBP1	21	Q5SRN2
RAWKETNMARTQILC	WFS1	676	O76024
IMAVSSSRECRVWLS	MYO7A	1516	Q13402
MERRAWSLQCTAFVL	PCSK1	1	P29120