Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	VN1R2 VN1R5 OR2F2 MAS1 OR1S1 OR1S2 GPR182 GPR82 OR10H4 GPR101 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 ACKR3 MRGPRX1 OR10AC1 OR1D5 MRGPRX3 ADGRE5 OR56B4 ADGRD1	5.71e-10	884	162	28	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	VN1R2 EPHB6 VN1R5 OR2F2 MAS1 HLA-DQB1 HLA-DQB2 OR1S1 OR1S2 GPR182 GPR82 OR10H4 GRIA4 GPR101 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 ACKR3 MRGPRX1 OR10AC1 OR1D5 MRGPRX3 ADGRE5 OR56B4 ADGRD1	3.61e-08	1353	162	32	GO:0004888
GeneOntologyMolecularFunction	olfactory receptor activity	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 OR10AC1 OR1D5 OR56B4	8.57e-08	431	162	17	GO:0004984
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNHD1 DNAH2 SPTBN5 DNAAF5	2.24e-04	37	162	4	GO:0045505
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	AKAP6 VN1R2 VN1R5 OR2F2 MAS1 OR1S1 OR1S2 GPR182 GPR82 OR10H4 GPR101 F2 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR12D1 OR10H3 OR10A4 RAPGEF3 OR51M1 ACKR3 MRGPRX1 OR10AC1 OR1D5 MRGPRX3 ADGRE5 CCL24 OR56B4 ADGRD1	3.48e-08	1395	162	32	GO:0007186
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 OR10AC1 OR1D5 OR56B4	5.60e-08	432	162	17	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	VN1R2 VN1R5 OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 OR10AC1 OR1D5 OR56B4	6.38e-08	547	162	19	GO:0007606
GeneOntologyBiologicalProcess	sensory perception of smell	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 OR10AC1 OR1D5 OR56B4	1.60e-07	465	162	17	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 OR10AC1 OR1D5 OR56B4	2.90e-07	485	162	17	GO:0050907
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 EYS OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 OR10AC1 OR1D5 OR56B4	7.90e-07	582	162	18	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 OR10AC1 OR1D5 OR56B4	8.50e-07	524	162	17	GO:0009593
GeneOntologyBiologicalProcess	sensory perception	VN1R2 VN1R5 OR2F2 OR1S1 OR1S2 LAMB2 OR10H4 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 EYS OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 USH1G OR10AC1 OR1D5 ALOXE3 NLGN2 RIMS1 OR56B4	1.01e-06	1072	162	25	GO:0007600
GeneOntologyBiologicalProcess	detection of stimulus	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR1D4 OR10Z1 OR9G9 PITPNM1 OR51L1 EYS OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 OR10AC1 OR1D5 OR56B4	4.15e-06	722	162	19	GO:0051606
Domain	G_PROTEIN_RECEP_F1_1	VN1R2 VN1R5 OR2F2 MAS1 OR1S1 OR1S2 GPR182 GPR82 OR10H4 GPR101 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR10H3 OR10A4 OR51M1 ACKR3 MRGPRX1 OR1D5 MRGPRX3 OR56B4	3.93e-09	685	159	24	PS00237
Domain	G_PROTEIN_RECEP_F1_2	VN1R2 VN1R5 OR2F2 MAS1 OR1S1 OR1S2 GPR182 GPR82 OR10H4 GPR101 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR10H3 OR10A4 OR51M1 ACKR3 MRGPRX1 OR1D5 MRGPRX3 OR56B4	4.65e-09	691	159	24	PS50262
Domain	GPCR_Rhodpsn	VN1R2 VN1R5 OR2F2 MAS1 OR1S1 OR1S2 GPR182 GPR82 OR10H4 GPR101 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR10H3 OR10A4 OR51M1 ACKR3 MRGPRX1 OR1D5 MRGPRX3 OR56B4	4.79e-09	692	159	24	IPR000276
Domain	GPCR_Rhodpsn_7TM	VN1R2 OR2F2 MAS1 OR1S1 OR1S2 GPR182 GPR82 OR10H4 GPR101 OR2F1 OR10Z1 OR9G9 OR51L1 OR12D2 OR10H3 OR10A4 OR51M1 ACKR3 MRGPRX1 OR1D5 MRGPRX3 OR56B4	5.89e-08	670	159	22	IPR017452
Domain	7tm_1	OR2F2 MAS1 OR1S1 OR1S2 GPR182 GPR82 OR10H4 GPR101 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR10H3 OR10A4 OR51M1 ACKR3 MRGPRX1 OR1D5 MRGPRX3 OR56B4	7.07e-08	677	159	22	PF00001
Domain	ARM-type_fold	MON2 STK36 TRPC4AP ATR NBEAL1 APC FRYL FOCAD ARFGEF3 DNAAF5 AP2A1 ARID2 UTP20 MMS19	1.27e-06	339	159	14	IPR016024
Domain	Olfact_rcpt	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR10H3 OR10A4 OR51M1 OR1D5 OR56B4	1.39e-06	393	159	15	IPR000725
Domain	HEAT	STK36 ATR DNAAF5 UTP20 MMS19	5.35e-05	48	159	5	PF02985
Domain	Cell_morpho_N	FRYL FRY	7.20e-05	2	159	2	IPR025614
Domain	CXorf40	EOLA1 EOLA2	7.20e-05	2	159	2	IPR033615
Domain	Cell_Morphogen_C	FRYL FRY	7.20e-05	2	159	2	IPR025481
Domain	MOR2-PAG1_mid	FRYL FRY	7.20e-05	2	159	2	IPR029473
Domain	MOR2-PAG1_mid	FRYL FRY	7.20e-05	2	159	2	PF14228
Domain	MOR2-PAG1_C	FRYL FRY	7.20e-05	2	159	2	PF14225
Domain	MOR2-PAG1_N	FRYL FRY	7.20e-05	2	159	2	PF14222
Domain	MRGPCRFAMILY	MAS1 MRGPRX1 MRGPRX3	9.50e-05	11	159	3	IPR026234
Domain	ARM-like	MON2 STK36 ATR APC FRYL DNAAF5 AP2A1 ARID2 UTP20 MMS19	1.09e-04	270	159	10	IPR011989
Domain	-	MON2 STK36 ATR APC FRYL DNAAF5 AP2A1 UTP20 MMS19	1.23e-04	222	159	9	1.25.10.10
Domain	HEAT	STK36 ATR DNAAF5 UTP20 MMS19	1.34e-04	58	159	5	IPR000357
Domain	SPEC	AKAP6 SYNE1 SPTBN5 SYNE3	1.51e-04	32	159	4	SM00150
Domain	Spectrin/alpha-actinin	AKAP6 SYNE1 SPTBN5 SYNE3	1.51e-04	32	159	4	IPR018159
Domain	ASCH_domain	EOLA1 EOLA2	2.15e-04	3	159	2	IPR007374
Domain	ASCH	EOLA1 EOLA2	2.15e-04	3	159	2	SM01022
Domain	KASH	SYNE1 SYNE3	4.27e-04	4	159	2	IPR012315
Domain	KASH	SYNE1 SYNE3	4.27e-04	4	159	2	PS51049
Domain	DCB_dom	MON2 ARFGEF3	4.27e-04	4	159	2	IPR032629
Domain	KASH	SYNE1 SYNE3	4.27e-04	4	159	2	SM01249
Domain	Sec7_C	MON2 ARFGEF3	4.27e-04	4	159	2	IPR015403
Domain	DUF1981	MON2 ARFGEF3	4.27e-04	4	159	2	PF09324
Domain	KASH	SYNE1 SYNE3	4.27e-04	4	159	2	PF10541
Domain	DCB	MON2 ARFGEF3	4.27e-04	4	159	2	PF16213
Domain	Ank_2	ANK2 ANKRD20A2P ANKRD20A3P ANKRD20A4P USH1G ANKRD28 TANC1 POTEA	5.19e-04	215	159	8	PF12796
Domain	TF_AP2	TFAP2B TFAP2C	7.08e-04	5	159	2	IPR004979
Domain	Groucho_enhance	TLE2 TLE4	7.08e-04	5	159	2	IPR009146
Domain	TF_AP2_C	TFAP2B TFAP2C	7.08e-04	5	159	2	IPR013854
Domain	TLE_N	TLE2 TLE4	7.08e-04	5	159	2	PF03920
Domain	Vmron_rcpt_1	VN1R2 VN1R5	7.08e-04	5	159	2	IPR004072
Domain	V1R	VN1R2 VN1R5	7.08e-04	5	159	2	PF03402
Domain	TF_AP-2	TFAP2B TFAP2C	7.08e-04	5	159	2	PF03299
Domain	Groucho/TLE_N	TLE2 TLE4	7.08e-04	5	159	2	IPR005617
Domain	Ank	ANK2 ANKRD20A2P ANKRD20A3P ANKRD20A4P USH1G ANKRD28 TANC1 POTEA	7.62e-04	228	159	8	PF00023
Domain	Spectrin	SYNE1 SPTBN5 SYNE3	9.46e-04	23	159	3	PF00435
Domain	LipOase_mml	ALOXE3 ALOX12B	1.06e-03	6	159	2	IPR001885
Domain	LIPOXYGENASE_1	ALOXE3 ALOX12B	1.06e-03	6	159	2	PS00711
Domain	LipOase_C	ALOXE3 ALOX12B	1.06e-03	6	159	2	IPR013819
Domain	LIPOXYGENASE_2	ALOXE3 ALOX12B	1.06e-03	6	159	2	PS00081
Domain	LipOase_Fe_BS	ALOXE3 ALOX12B	1.06e-03	6	159	2	IPR020833
Domain	LipOase_CS	ALOXE3 ALOX12B	1.06e-03	6	159	2	IPR020834
Domain	Lipoxygenase	ALOXE3 ALOX12B	1.06e-03	6	159	2	PF00305
Domain	LIPOXYGENASE_3	ALOXE3 ALOX12B	1.06e-03	6	159	2	PS51393
Domain	LipOase	ALOXE3 ALOX12B	1.06e-03	6	159	2	IPR000907
Domain	-	ANK2 ANKRD20A2P ANKRD20A3P ANKRD20A4P USH1G ANKRD28 TANC1 POTEA	1.31e-03	248	159	8	1.25.40.20
Domain	ANK	ANK2 ANKRD20A2P ANKRD20A3P ANKRD20A4P USH1G ANKRD28 TANC1 POTEA	1.41e-03	251	159	8	SM00248
Domain	ANK_REPEAT	ANK2 ANKRD20A2P ANKRD20A3P ANKRD20A4P USH1G ANKRD28 TANC1 POTEA	1.49e-03	253	159	8	PS50088
Domain	Ankyrin_rpt-contain_dom	ANK2 ANKRD20A2P ANKRD20A3P ANKRD20A4P USH1G ANKRD28 TANC1 POTEA	1.52e-03	254	159	8	IPR020683
Domain	ANK_REP_REGION	ANK2 ANKRD20A2P ANKRD20A3P ANKRD20A4P USH1G ANKRD28 TANC1 POTEA	1.52e-03	254	159	8	PS50297
Domain	Ankyrin_rpt	ANK2 ANKRD20A2P ANKRD20A3P ANKRD20A4P USH1G ANKRD28 TANC1 POTEA	1.85e-03	262	159	8	IPR002110
Domain	Spectrin_repeat	SYNE1 SPTBN5 SYNE3	1.88e-03	29	159	3	IPR002017
Domain	MHC_II_b_N	HLA-DQB1 HLA-DQB2	1.95e-03	8	159	2	PD000328
Domain	MHC_II_b_N	HLA-DQB1 HLA-DQB2	2.49e-03	9	159	2	IPR000353
Domain	MHC_II_beta	HLA-DQB1 HLA-DQB2	2.49e-03	9	159	2	SM00921
Domain	MHC_II_beta	HLA-DQB1 HLA-DQB2	2.49e-03	9	159	2	PF00969
Domain	RFX_DNA_binding	RFX4 ARID2	2.49e-03	9	159	2	PF02257
Domain	DNA-bd_RFX	RFX4 ARID2	2.49e-03	9	159	2	IPR003150
Domain	RFX_DBD	RFX4 ARID2	2.49e-03	9	159	2	PS51526
Domain	HEAT_REPEAT	ATR DNAAF5 UTP20 MMS19	3.00e-03	70	159	4	PS50077
Domain	IPPc	INPP5B OCRL	3.10e-03	10	159	2	IPR000300
Domain	IPPc	INPP5B OCRL	3.10e-03	10	159	2	SM00128
Domain	Ephrin_rec_like	EPHB6 SCUBE2	3.77e-03	11	159	2	PF07699
Domain	HlyIII	PAQR8 PAQR5	3.77e-03	11	159	2	PF03006
Domain	AdipoR/HlyIII-related	PAQR8 PAQR5	3.77e-03	11	159	2	IPR004254
Domain	MHC_II_a/b_N	HLA-DQB1 HLA-DQB2	6.13e-03	14	159	2	IPR014745
Domain	Dynein_HC_stalk	DNHD1 DNAH2	6.13e-03	14	159	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH2	6.13e-03	14	159	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH2	6.13e-03	14	159	2	PF08393
Domain	MT	DNHD1 DNAH2	6.13e-03	14	159	2	PF12777
Domain	-	HLA-DQB1 HLA-DQB2	6.13e-03	14	159	2	3.10.320.10
Domain	DHC_fam	DNHD1 DNAH2	7.03e-03	15	159	2	IPR026983
Domain	BAR	ARHGEF38 SH3GLB1	7.03e-03	15	159	2	SM00721
Domain	Dynein_heavy	DNHD1 DNAH2	7.03e-03	15	159	2	PF03028
Domain	Dynein_heavy_dom	DNHD1 DNAH2	7.03e-03	15	159	2	IPR004273
Domain	BAR_dom	ARHGEF38 SH3GLB1	7.99e-03	16	159	2	IPR004148
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR10H3 OR10A4 OR51M1 OR10AC1 OR1D5 OR56B4	4.27e-07	417	119	16	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR1D4 OR10Z1 OR51L1 OR12D2 OR10H3 OR10A4 OR51M1 OR1D5 OR56B4	5.00e-06	389	119	14	M14091
Pathway	WP_GPCRS_ODORANT	VN1R5 GPR182 GPR82 OR10H4 GPR101 OR10H3 MRGPRX1 MRGPRX3 ADGRD1	7.13e-06	157	119	9	MM15872
Pathway	REACTOME_SENSORY_PERCEPTION	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR1D4 OR10Z1 OR9G9 OR51L1 OR12D2 OR10H3 OR10A4 OR51M1 USH1G OR10AC1 OR1D5 OR56B4	2.38e-05	636	119	17	M41834
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR10Z1 OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 OR10AC1 OR1D5 OR56B4	1.25e-09	340	167	14	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR10Z1 OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 OR10AC1 OR1D5 OR56B4	1.40e-09	343	167	14	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR10Z1 OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 OR10AC1 OR1D5 OR56B4	1.56e-09	346	167	14	14611657
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR10Z1 OR12D2 OR12D1 OR10H3 OR10A4 OR51M1 OR1D5 OR56B4	1.20e-08	340	167	13	11875048
Pubmed	The human olfactory receptor gene family.	OR2F2 OR1S1 OR1S2 OR10H4 OR2F1 OR1D4 OR10Z1 OR51L1 OR12D2 OR10H3 OR10A4 OR51M1 OR10AC1 OR1D5 OR56B4	6.26e-08	541	167	15	14983052
Pubmed	Regulation of AP-2 and apoptosis in developing eye in a vitamin A-deficiency model.	TFAP2B TFAP2C AP2A1	4.33e-07	4	167	3	12749383
Pubmed	Identification of G protein-coupled receptor genes from the human genome sequence.	VN1R2 VN1R5 GPR82 GPR101 MRGPRX1	2.81e-06	46	167	5	12044878
Pubmed	Expression of testicular germ cell genes identified by differential display analysis.	ANKRD20A3P ANKRD20A8P ANKRD20A4P	5.98e-06	8	167	3	12634303
Pubmed	Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes.	MAS1 MRGPRX1 MRGPRX3	5.98e-06	8	167	3	24583173
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TRPC4AP UBE4B FRMPD2 ARHGEF38 PAQR5 NAPA FRYL ZSWIM1 SSPOP PCNX2 ZNF462 ARFGEF3 DNAAF5 TECPR2 ACKR3 SNTG2 NLGN2 TANC1 RIMS1 ADGRD1 NLK	1.02e-05	1489	167	21	28611215
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	AKAP6 MAST4 TECPR2 ZBTB5 ANKRD28 RIMS1	1.15e-05	104	167	6	9205841
Pubmed	Loss of the EPH receptor B6 contributes to colorectal cancer metastasis.	EPHB6 APC	2.29e-05	2	167	2	28262839
Pubmed	Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.	ALOXE3 ALOX12B	2.29e-05	2	167	2	11773004
Pubmed	X-inactivation analysis of embryonic lethality in Ocrl wt/-; Inpp5b-/- mice.	INPP5B OCRL	2.29e-05	2	167	2	20195868
Pubmed	Knockdown of REV3 synergizes with ATR inhibition to promote apoptosis induced by cisplatin in lung cancer cells.	ATR REV3L	2.29e-05	2	167	2	28075014
Pubmed	Cytoskeletal interactions at the nuclear envelope mediated by nesprins.	SYNE1 SYNE3	2.29e-05	2	167	2	22518138
Pubmed	Tissue and zonal-specific expression of an olfactory receptor transgene.	OR10H4 OR10H3	2.29e-05	2	167	2	9412503
Pubmed	Disrupted sperm function and fertilin beta processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b.	INPP5B OCRL	2.29e-05	2	167	2	11784089
Pubmed	Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice.	INPP5B OCRL	2.29e-05	2	167	2	9593760
Pubmed	Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.	ALOXE3 ALOX12B	2.29e-05	2	167	2	15629692
Pubmed	EphB6 overexpression and Apc mutation together promote colorectal cancer.	EPHB6 APC	2.29e-05	2	167	2	27145271
Pubmed	OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells.	INPP5B OCRL	2.29e-05	2	167	2	25305077
Pubmed	The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier.	ALOXE3 ALOX12B	2.29e-05	2	167	2	24021977
Pubmed	Kidney Tubular Ablation of Ocrl/Inpp5b Phenocopies Lowe Syndrome Tubulopathy.	INPP5B OCRL	2.29e-05	2	167	2	27895154
Pubmed	Mouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy.	INPP5B OCRL	2.29e-05	2	167	2	21183592
Pubmed	GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro.	GPR182 MRGPRX3	2.29e-05	2	167	2	29408502
Pubmed	Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B.	ALOXE3 ALOX12B	2.29e-05	2	167	2	19131948
Pubmed	12R-lipoxygenase deficiency disrupts epidermal barrier function.	ALOXE3 ALOX12B	2.29e-05	2	167	2	17403930
Pubmed	Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase.	INPP5B OCRL	2.29e-05	2	167	2	19700499
Pubmed	Meta-Analysis of Mutations in ALOX12B or ALOXE3 Identified in a Large Cohort of 224 Patients.	ALOXE3 ALOX12B	2.29e-05	2	167	2	33435499
Pubmed	Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope.	ALOXE3 ALOX12B	2.29e-05	2	167	2	21558561
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 STK36 UBE4B MED14 LAMB2 FRYL REV3L PCNX2 FOCAD SYNE3 AP2A1 ZBED4 PLEKHM2 NLGN2 TANC1 TTC38 PKN3	2.57e-05	1105	167	17	35748872
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	MON2 TBRG4 ATR ARFGEF3 DNAAF5 AP2A1 MMS19	3.10e-05	183	167	7	23956138
Pubmed	Personal receptor repertoires: olfaction as a model.	OR1S1 OR2F1 OR12D2 OR12D1	3.33e-05	38	167	4	22908908
Pubmed	Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis.	OR10H4 OR10H3 OR10A4	5.82e-05	16	167	3	17521568
Pubmed	The role of lipoxygenases in epidermis.	ALOXE3 ALOX12B	6.85e-05	3	167	2	23954555
Pubmed	Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation.	MRGPRX1 MRGPRX3	6.85e-05	3	167	2	28768771
Pubmed	The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms.	MRGPRX1 MRGPRX3	6.85e-05	3	167	2	26022362
Pubmed	Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways.	MRGPRX1 MRGPRX3	6.85e-05	3	167	2	27215903
Pubmed	OCRL deficiency impairs endolysosomal function in a humanized mouse model for Lowe syndrome and Dent disease.	INPP5B OCRL	6.85e-05	3	167	2	30590522
Pubmed	Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.	ALOXE3 ALOX12B	6.85e-05	3	167	2	17139268
Pubmed	Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs.	MRGPRX1 MRGPRX3	6.85e-05	3	167	2	11850634
Pubmed	TRIM37 Augments AP-2γ Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression.	TFAP2B TFAP2C	6.85e-05	3	167	2	35864973
Pubmed	cDNA cloning, genomic structure, and chromosomal localization of a novel murine epidermis-type lipoxygenase.	ALOXE3 ALOX12B	6.85e-05	3	167	2	10366447
Pubmed	A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism.	INPP5B OCRL	6.85e-05	3	167	2	19536138
Pubmed	The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis.	APC MSH3	6.85e-05	3	167	2	11691815
Pubmed	Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions.	MRGPRX1 MRGPRX3	6.85e-05	3	167	2	18250432
Pubmed	Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events.	PAQR8 PAQR5	6.85e-05	3	167	2	21761364
Pubmed	Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation.	ALOXE3 ALOX12B	6.85e-05	3	167	2	22832496
Pubmed	Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes.	PAQR8 PAQR5	6.85e-05	3	167	2	12574519
Pubmed	Comprehensive analysis of the expression and prognosis for TFAP2 in human lung carcinoma.	TFAP2B TFAP2C	6.85e-05	3	167	2	32462520
Pubmed	The effect of EBV on WIF1, NLK, and APC gene methylation and expression in gastric carcinoma and nasopharyngeal cancer.	APC NLK	6.85e-05	3	167	2	28543390
Pubmed	Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients.	ALOXE3 ALOX12B	6.85e-05	3	167	2	19890349
Pubmed	Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.	INPP5B OCRL	6.85e-05	3	167	2	24704254
Pubmed	A novel alternative spliced variant of the transcription factor AP2alpha is expressed in the murine ocular lens.	TFAP2B TFAP2C	6.85e-05	3	167	2	9758708
Pubmed	Developmental regulation and overexpression of the transcription factor AP-2, a potential regulator of the timing of Schwann cell generation.	TFAP2B TFAP2C	6.85e-05	3	167	2	11553286
Pubmed	bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells.	MRGPRX1 MRGPRX3	6.85e-05	3	167	2	10662793
Pubmed	CXCR7/CXCR4 heterodimer-induced histone demethylation: a new mechanism of colorectal tumorigenesis.	APC ACKR3	6.85e-05	3	167	2	30337690
Pubmed	Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.	APC SESN2	6.85e-05	3	167	2	26913956
Pubmed	OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring.	INPP5B OCRL	6.85e-05	3	167	2	33987909
Pubmed	cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning.	RAPGEF3 RIMS1	6.85e-05	3	167	2	37159499
Pubmed	Mas-related G protein-coupled receptor C11 (Mrgprc11) induces visceral hypersensitivity in the mouse colon: A novel target in gut nociception?	MRGPRX1 MRGPRX3	6.85e-05	3	167	2	31119828
Pubmed	Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor.	PAQR8 PAQR5	6.85e-05	3	167	2	12601167
Pubmed	Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors.	TFAP2B TFAP2C	6.85e-05	3	167	2	8661133
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	TTC28 APC DENND4C ARFGEF3 MAST4 ANKRD28 TANC1	7.19e-05	209	167	7	36779422
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	MON2 KIF21B OR2F2 UBE4B RBBP7 INPP5B SPG11 VARS2 OLA1 TFAP2C ACSL3 TADA1 ALKBH8 ZBED4 ARID2 HELZ SESN2 FITM2	7.51e-05	1327	167	18	32694731
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	MON2 TBRG4 MED14 NAPA TMEM214 MSH3 ACSL3 INTS10 AP2A1 ANKRD28 MMS19	9.01e-05	560	167	11	35241646
Pubmed	TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination.	TLE2 TLE4	1.37e-04	4	167	2	8645603
Pubmed	Transcription factor AP-2gamma regulates murine adenosine deaminase gene expression during placental development.	TFAP2B TFAP2C	1.37e-04	4	167	2	9765260
Pubmed	Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.	HLA-DQB1 HLA-DQB2	1.37e-04	4	167	2	3036828
Pubmed	β-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminals.	RAPGEF3 RIMS1	1.37e-04	4	167	2	24036110
Pubmed	Novel human vomeronasal receptor-like genes reveal species-specific families.	VN1R2 VN1R5	1.37e-04	4	167	2	12123587
Pubmed	Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	33727332
Pubmed	Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	35882236
Pubmed	Molecular Signature of Pruriceptive MrgprA3+ Neurons.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	32234460
Pubmed	The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.	AKAP6 RAPGEF3	1.37e-04	4	167	2	16177794
Pubmed	Overlap of direct and indirect alloreactive T-cell repertoires when MHC polymorphism is limited to the peptide binding groove.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	11821156
Pubmed	Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	23074220
Pubmed	Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	33358893
Pubmed	USP48 alleviates bone cancer pain and regulates MrgC stabilization in spinal cord neurons of male mice.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	36864656
Pubmed	Low maternal care enhances the skin barrier resistance of offspring in mice.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	31295326
Pubmed	Mammalian sperm head formation involves different polarization of two novel LINC complexes.	SYNE1 SYNE3	1.37e-04	4	167	2	20711465
Pubmed	The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation.	TFAP2B TFAP2C	1.37e-04	4	167	2	19115315
Pubmed	MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	29064954
Pubmed	A fraction of mouse sperm chromatin is organized in nucleosomal hypersensitive domains enriched in retroposon DNA.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	10504302
Pubmed	A mechanically activated ion channel is functionally expressed in the MrgprB4 positive sensory neurons, which detect stroking of hairy skin in mice.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	28545921
Pubmed	Substance P activates Mas-related G protein-coupled receptors to induce itch.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	28219706
Pubmed	130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus.	EOLA1 EOLA2	1.37e-04	4	167	2	8717057
Pubmed	Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	17975009
Pubmed	Characterization of new G protein-coupled adenine receptors in mouse and hamster.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	23608776
Pubmed	The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	21775281
Pubmed	Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons.	MRGPRX1 MRGPRX3	1.37e-04	4	167	2	26874069
Pubmed	A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression.	ALOXE3 ALOX12B	1.37e-04	4	167	2	11350124
Pubmed	The expression of epidermal lipoxygenases and transglutaminase-1 is perturbed by NIPAL4 mutations: indications of a common metabolic pathway essential for skin barrier homeostasis.	ALOXE3 ALOX12B	1.37e-04	4	167	2	22622417
Pubmed	A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.	HLA-DQB1 HLA-DQB2	1.37e-04	4	167	2	21750111
Pubmed	Multiple new and isolated families within the mouse superfamily of V1r vomeronasal receptors.	VN1R2 VN1R5	1.37e-04	4	167	2	11802169
Pubmed	Unraveling genetic modifiers in the gria4 mouse model of absence epilepsy.	GRIA4 PCNX2	1.37e-04	4	167	2	25010494
Pubmed	Expression of Tfap2d, the gene encoding the transcription factor Ap-2 delta, during mouse embryogenesis.	TFAP2B TFAP2C	1.37e-04	4	167	2	12711551
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	AKAP6 EPHB6 ANK2 TTC28 UBE4B SYNE1 APC NAPA BRCC3 MSH3 REV3L FOCAD FRY AP2A1 ZNF334 SLF2 ZBTB5	1.62e-04	1285	167	17	35914814
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MON2 TTC28 UBE4B SYNE1 FOCAD ARFGEF3 ZBED4 PLEKHM2 TLE4	1.66e-04	407	167	9	12693553
Cytoband	6p22.2-p21.31	OR12D2 OR12D1	1.31e-04	5	167	2	6p22.2-p21.31
Cytoband	12p13.31	FOXJ2 DDX12P PLEKHG6 CLEC4D	2.15e-04	80	167	4	12p13.31
Cytoband	11p15.4	DNHD1 OR51L1 OR10A4 OR51M1 OR56B4	8.60e-04	200	167	5	11p15.4
Cytoband	17p13.1	DNAH2 ALOXE3 NLGN2 ALOX12B	9.39e-04	118	167	4	17p13.1
Cytoband	7q35	OR2F2 OR2F1 OR10AC1	1.08e-03	55	167	3	7q35
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	DNHD1 OR51L1 SCUBE2 OR10A4 OR51M1 MRGPRX1 MRGPRX3 OR56B4	1.14e-03	564	167	8	chr11p15
Cytoband	20q13.12	ZSWIM1 ZNF334 FITM2	1.39e-03	60	167	3	20q13.12
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	DNAH2 OR1D4 OR1D5 ALOXE3 NLGN2 ALOX12B	1.75e-03	346	167	6	chr17p13
Cytoband	Ensembl 112 genes in cytogenetic band chr7q35	OR2F2 OR2F1 OR10AC1	1.83e-03	66	167	3	chr7q35
GeneFamily	G protein-coupled receptors, Class A orphans	MAS1 GPR182 GPR82 GPR101 MRGPRX1 MRGPRX3	1.31e-05	78	120	6	262
GeneFamily	Olfactory receptors, family 10	OR10H4 OR10Z1 OR10H3 OR10A4 OR10AC1	7.66e-05	66	120	5	157
GeneFamily	Olfactory receptors, family 12	OR12D2 OR12D1	1.30e-04	3	120	2	160
GeneFamily	Olfactory receptors, family 1	OR1S1 OR1S2 OR1D4 OR1D5	1.40e-04	40	120	4	147
GeneFamily	Ankyrin repeat domain containing	ANK2 ANKRD20A2P ANKRD20A3P ANKRD20A4P USH1G ANKRD28 TANC1 POTEA	2.13e-04	242	120	8	403
GeneFamily	Spectrin repeat containing nuclear envelope family	SYNE1 SYNE3	2.60e-04	4	120	2	1252
GeneFamily	Arachidonate lipoxygenases	ALOXE3 ALOX12B	6.44e-04	6	120	2	407
GeneFamily	Progestin and adipoQ receptor family	PAQR8 PAQR5	2.31e-03	11	120	2	930
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_k-means-cluster#4_top-relative-expression-ranked_500	NBEAL1 MED14 APC MSH3 REV3L TFAP2B CHPT1 ARID2	1.42e-05	163	142	8	gudmap_developingKidney_e15.5_cortic collect duct_500_k4
ToppCell	LPS-antiTNF-Endothelial-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TFAP2C PLEKHG6 ZNF334 UTP20 ALOXE3 ABCC2 RNF207	1.18e-06	144	166	7	75b16adfbe84f69376e6566d531ba7919d5c5192
ToppCell	NS-critical-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ANK2 ZSCAN31 LAMB2 TOP6BL ZNF462 ARFGEF3 SCUBE2	5.37e-06	181	166	7	cfc3ed541d93158ce26641ea30b7573d93600a11
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	INPP5B COL27A1 ARHGEF38 TFAP2C FRY TLE4 ALOX12B	7.64e-06	191	166	7	54f07e4de61735051498846afb44b1798bed8144
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	AKAP6 ANK2 GREB1L FRY MAST4 CHPT1 TANC1	7.90e-06	192	166	7	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
Disease	ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 2	ALOXE3 ALOX12B	2.67e-05	2	153	2	242100
Disease	Autosomal recessive congenital ichthyosis 2	ALOXE3 ALOX12B	2.67e-05	2	153	2	cv:C3888093
Disease	ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL, NONBULLOUS, 1	ALOXE3 ALOX12B	2.67e-05	2	153	2	C1855792
Disease	Self-Healing Collodion Baby	ALOXE3 ALOX12B	7.99e-05	3	153	2	C1855789
Disease	Colorectal Neoplasms	CALCOCO2 ABCA13 SYNE1 APC ACKR3 ZKSCAN3 SESN2 ABCC2	1.04e-04	277	153	8	C0009404
Disease	Ichthyosis Congenita I	ALOXE3 ALOX12B	1.59e-04	4	153	2	C4551630
Disease	Harlequin Fetus	ALOXE3 ALOX12B	1.59e-04	4	153	2	C0239849
Disease	Ichthyosis Congenita II	ALOXE3 ALOX12B	1.59e-04	4	153	2	C3536797
Disease	Collodion Fetus	ALOXE3 ALOX12B	1.59e-04	4	153	2	C3543867
Disease	type 1 diabetes mellitus, latent autoimmune diabetes in adults	HLA-DQB1 HLA-DQB2	1.59e-04	4	153	2	EFO_0009706, MONDO_0005147
Disease	Congenital ichthyosis	ALOXE3 ALOX12B	2.64e-04	5	153	2	C0020758
Disease	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase measurement	LRR1 CHPT1	2.64e-04	5	153	2	EFO_0801370
Disease	narcolepsy-cataplexy syndrome, age at onset	HLA-DQB1 HLA-DQB2	2.64e-04	5	153	2	EFO_0004847, MONDO_0016158
Disease	HPV seropositivity	HLA-DQB1 HLA-DQB2	2.64e-04	5	153	2	EFO_0004510
Disease	level of coiled-coil domain-containing protein 134 in blood serum	HLA-DQB1 HLA-DQB2	2.64e-04	5	153	2	OBA_2044258
Disease	Varicella zoster virus seropositivity	HLA-DQB1 HLA-DQB2	2.64e-04	5	153	2	EFO_0009340
Disease	Colorectal Carcinoma	AKAP6 CALCOCO2 EPHB6 ANK2 ABCA13 SYNE1 FRMPD2 APC ACKR3 ZKSCAN3 SESN2 ABCC2	3.13e-04	702	153	12	C0009402
Disease	rheumatoid arthritis, COVID-19	ZSCAN31 INPP5B FRYL ZKSCAN3	3.47e-04	64	153	4	EFO_0000685, MONDO_0100096
Disease	antibody measurement, Epstein-Barr virus infection	HLA-DQB1 HLA-DQB2	3.95e-04	6	153	2	EFO_0000769, EFO_0004556
Disease	pneumocystosis (biomarker_via_orthology)	HLA-DQB1 HLA-DQB2	3.95e-04	6	153	2	DOID:11339 (biomarker_via_orthology)
Disease	pemphigus	HLA-DQB1 HLA-DQB2	3.95e-04	6	153	2	EFO_1000749
Disease	grip strength measurement	HLA-DQB1 HLA-DQB2 ZNF322 OCRL OLA1 TFAP2B SCUBE2 TECPR2	5.04e-04	350	153	8	EFO_0006941
Disease	antinuclear antibody measurement	HLA-DQB1 HLA-DQB2	5.51e-04	7	153	2	EFO_0005949
Disease	Anti-Helicobacter pylori IgG measurement	HLA-DQB1 HLA-DQB2	5.51e-04	7	153	2	EFO_0009352
Disease	nephrosis (implicated_via_orthology)	LAMB2 F2	5.51e-04	7	153	2	DOID:2527 (implicated_via_orthology)
Disease	bullous pemphigoid	HLA-DQB1 HLA-DQB2 MAST4	7.27e-04	34	153	3	EFO_0007187
Disease	IgG index	HLA-DQB1 HLA-DQB2	7.33e-04	8	153	2	EFO_0006929
Disease	PAX-interacting protein 1 measurement	HLA-DQB1 HLA-DQB2	7.33e-04	8	153	2	EFO_0801868
Disease	soluble CD163 measurement	HLA-DQB1 HLA-DQB2	7.33e-04	8	153	2	EFO_0020072
Disease	gdnf family receptor alpha-1 measurement	HLA-DQB1 HLA-DQB2	7.33e-04	8	153	2	EFO_0020400
Disease	pulmonary function measurement, forced expiratory volume	ZSCAN31 ARHGEF38 ZKSCAN3	9.33e-04	37	153	3	EFO_0003892, EFO_0004314
Disease	zinc fingers and homeoboxes protein 3 measurement	HLA-DQB1 HLA-DQB2	9.39e-04	9	153	2	EFO_0803299
Disease	Epstein Barr virus nuclear antigen 1 IgG measurement	HLA-DQB1 HLA-DQB2	9.39e-04	9	153	2	EFO_0007790
Disease	inclusion body myositis	HLA-DQB1 HLA-DQB2	9.39e-04	9	153	2	EFO_0007323
Disease	head and neck malignant neoplasia	HLA-DQB1 HLA-DQB2	9.39e-04	9	153	2	EFO_0006859
Disease	HLA class II histocompatibility antigen, DQ alpha 2 chain measurement	HLA-DQB1 HLA-DQB2	9.39e-04	9	153	2	EFO_0801686
Disease	seropositivity measurement	HLA-DQB1 HLA-DQB2	9.39e-04	9	153	2	EFO_0007034
Disease	latent autoimmune diabetes in adults, type 2 diabetes mellitus	HLA-DQB1 HLA-DQB2	9.39e-04	9	153	2	EFO_0009706, MONDO_0005148
Disease	celiac disease (is_implicated_in)	HLA-DQB1 F2	1.17e-03	10	153	2	DOID:10608 (is_implicated_in)
Disease	peptidoglycan recognition protein 1 measurement	HLA-DQB1 HLA-DQB2	1.17e-03	10	153	2	EFO_0020624
Disease	CCL19 measurement	HLA-DQB1 HLA-DQB2	1.17e-03	10	153	2	EFO_0009415
Disease	cervical carcinoma, Cervical Intraepithelial Neoplasia Grade 2/3	HLA-DQB1 HLA-DQB2	1.17e-03	10	153	2	EFO_0001061, EFO_1000166
Disease	secreted and transmembrane protein 1 measurement	HLA-DQB1 HLA-DQB2	1.17e-03	10	153	2	EFO_0021852
Disease	chronic bronchitis	HLA-DQB1 HLA-DQB2	1.42e-03	11	153	2	EFO_0006505
Disease	apolipoprotein M measurement	HLA-DQB1 HLA-DQB2	1.42e-03	11	153	2	EFO_0021945
Disease	cAMP-specific 3',5'-cyclic phosphodiesterase 4D measurement	HLA-DQB1 HLA-DQB2	1.42e-03	11	153	2	EFO_0020224
Disease	Congenital Nonbullous Ichthyosiform Erythroderma	ALOXE3 ALOX12B	1.42e-03	11	153	2	C0079154
Disease	head and neck squamous cell carcinoma	HLA-DQB1 HLA-DQB2	1.42e-03	11	153	2	EFO_0000181
Disease	sleep disorder (implicated_via_orthology)	TFAP2B TFAP2C	1.42e-03	11	153	2	DOID:535 (implicated_via_orthology)
Disease	colon cancer (implicated_via_orthology)	ATR APC	1.42e-03	11	153	2	DOID:219 (implicated_via_orthology)
Disease	Congenital ichthyosis of skin	ALOXE3 ALOX12B	1.42e-03	11	153	2	cv:C0020758
Disease	uveitis (implicated_via_orthology)	HLA-DQB1 HLA-DQB2	1.42e-03	11	153	2	DOID:13141 (implicated_via_orthology)
Disease	endometrial carcinoma (is_implicated_in)	APC MSH3	1.70e-03	12	153	2	DOID:2871 (is_implicated_in)
Disease	rac GTPase-activating protein 1 measurement	HLA-DQB1 HLA-DQB2	1.70e-03	12	153	2	EFO_0801985
Disease	Alzheimer disease, dementia	RFX4 ZNF334	1.70e-03	12	153	2	MONDO_0001627, MONDO_0004975
Disease	squamous cell lung carcinoma	HLA-DQB2 ZNF322 VARS2 FRY RIMS1	1.73e-03	165	153	5	EFO_0000708
Disease	oropharynx cancer	HLA-DQB1 HLA-DQB2 ACSL3	1.76e-03	46	153	3	EFO_1001931
Disease	rheumatoid arthritis, smoking status measurement, ACPA-positive rheumatoid arthritis	HLA-DQB1 HLA-DQB2	2.01e-03	13	153	2	EFO_0000685, EFO_0006527, EFO_0009459
Disease	Genetic chronic primary adrenal insufficiency	HLA-DQB1 HLA-DQB2	2.01e-03	13	153	2	Orphanet_101960
Disease	autoimmune hepatitis (is_implicated_in)	HLA-DQB1 F2	2.01e-03	13	153	2	DOID:2048 (is_implicated_in)
Disease	oral cavity cancer	HLA-DQB1 HLA-DQB2	2.33e-03	14	153	2	EFO_0005570
Disease	C-C motif chemokine 19 measurement	HLA-DQB1 HLA-DQB2	2.33e-03	14	153	2	EFO_0008047
Disease	oligoclonal band measurement, multiple sclerosis	HLA-DQB1 HLA-DQB2	2.33e-03	14	153	2	EFO_0005206, MONDO_0005301
Disease	lung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma	HLA-DQB1 HLA-DQB2 FRY	2.51e-03	52	153	3	EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575
Disease	liver neoplasm	HLA-DQB1 HLA-DQB2	2.68e-03	15	153	2	EFO_1001513
Disease	Non-steroidal anti-inflammatory and antirheumatic product use measurement	HLA-DQB1 HLA-DQB2	2.68e-03	15	153	2	EFO_0009935
Disease	Churg-Strauss syndrome	HLA-DQB1 HLA-DQB2	2.68e-03	15	153	2	EFO_0007208
Disease	pemphigus vulgaris	HLA-DQB1 HLA-DQB2	3.06e-03	16	153	2	EFO_0004719
Disease	gastroparesis	HLA-DQB1 HLA-DQB2	3.06e-03	16	153	2	EFO_1000948
Disease	Polyposis, Adenomatous Intestinal	APC MSH3	3.06e-03	16	153	2	C2713442
Disease	Familial Intestinal Polyposis	APC MSH3	3.06e-03	16	153	2	C2713443
Disease	refractive error, age at onset, Myopia	AKAP6 FRMPD2 GRIA4 TFAP2B ARID2	3.41e-03	193	153	5	EFO_0004847, HP_0000545, MONDO_0004892
Disease	Benign neoplasm of stomach	ATR APC	3.45e-03	17	153	2	C0153943
Disease	Antihistamine use measurement	HLA-DQB1 HLA-DQB2	3.45e-03	17	153	2	EFO_0009943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ATR APC	3.45e-03	17	153	2	C0496905
Disease	high altitude adaptation	HLA-DQB1 HLA-DQB2	3.45e-03	17	153	2	EFO_0009105
Disease	Carcinoma in situ of stomach	ATR APC	3.45e-03	17	153	2	C0154060
Disease	response to interferon-beta, anti-drug antibody measurement	HLA-DQB1 HLA-DQB2	3.45e-03	17	153	2	EFO_0010559, GO_0035456
Disease	Graves disease, thyrotoxic periodic paralysis	HLA-DQB1 HLA-DQB2	3.45e-03	17	153	2	EFO_0004237, MONDO_0019201
Disease	Moyamoya Disease	HLA-DQB1 BRCC3	3.45e-03	17	153	2	C0026654
Disease	Adenomatous Polyposis Coli	APC MSH3	3.45e-03	17	153	2	C0032580
Disease	lung carcinoma	ZSCAN31 HLA-DQB1 HLA-DQB2 ZNF322 FRY PLEKHG6 SLF2 RIMS1	3.77e-03	482	153	8	EFO_0001071
Disease	neuroimaging measurement	KIF21B NBEAL1 HLA-DQB1 HLA-DQB2 APC FRYL REV3L DENND4C ZNF462 FBXL7 MAST4 ACKR3 TLE4	3.86e-03	1069	153	13	EFO_0004346
Disease	serum IgG measurement	HLA-DQB1 HLA-DQB2	3.87e-03	18	153	2	EFO_0004565
Disease	tropical spastic paraparesis	HLA-DQB1 HLA-DQB2	3.87e-03	18	153	2	EFO_0007527
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	HLA-DQB1 HLA-DQB2 SPG11	3.95e-03	61	153	3	EFO_0008317, EFO_0008596, EFO_0020946
Disease	age at diagnosis, type 1 diabetes mellitus	HLA-DQB1 HLA-DQB2 EYS	4.13e-03	62	153	3	EFO_0004918, MONDO_0005147
Disease	Pancreatic carcinoma	APC ALOX12B	4.31e-03	19	153	2	C0235974
Disease	hepatitis B virus infection	HLA-DQB1 HLA-DQB2	4.31e-03	19	153	2	EFO_0004197
Disease	angiopoietin-1 receptor measurement	HLA-DQB1 HLA-DQB2	4.31e-03	19	153	2	EFO_0010600
Disease	sarcoidosis	HLA-DQB1 HLA-DQB2 CCL24	4.52e-03	64	153	3	MONDO_0019338
Disease	uric acid measurement	SWT1 HLA-DQB1 HLA-DQB2 TOP6BL TFAP2B STC1 ANKRD28 SESN2 TANC1	4.68e-03	610	153	9	EFO_0004761
Disease	white matter integrity	NBEAL1 HLA-DQB1 HLA-DQB2 FBXL7	4.76e-03	130	153	4	EFO_0004641
Disease	anti-Mullerian hormone measurement	TTC28 OR56B4	4.77e-03	20	153	2	EFO_0004769
Disease	end stage renal disease (implicated_via_orthology)	F2 ABCC2	4.77e-03	20	153	2	DOID:783 (implicated_via_orthology)
Disease	neoplasm of mature B-cells	HLA-DQB1 HLA-DQB2	4.77e-03	20	153	2	EFO_0000096
Disease	polymyositis	HLA-DQB1 HLA-DQB2	4.77e-03	20	153	2	EFO_0003063
Disease	magnesium measurement	TTC28 G3BP2 PRMT7	4.93e-03	66	153	3	EFO_0004845
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	HLA-DQB1 HLA-DQB2 SPG11	5.14e-03	67	153	3	EFO_0008595, EFO_0020946

Protein segments in the cluster

Peptide	Gene	Start	Entry
LAASNGHLHCLSFLV	USH1G	71	Q495M9
LSSQRNCTIAVHIAH	EOLA1	31	Q8TE69
LSSQRNCTIAVHIAH	EOLA2	31	Q96DE9
TIVTSLLFLGVCAHH	CCL24	6	O00175
DCHLQAFVLHLAQRS	CCL27	61	Q9Y4X3
LHLACASGHVQVVTL	ANKRD20A8P	71	Q5CZ79
IQNCLSHFSLITHGF	TFAP2C	386	Q92754
TTEACHHTRLIFVFS	LINC00269	111	Q8N2A0
HQDCLLFATSHLISL	ADGRD1	451	Q6QNK2
ACISIAVIHHFATAE	ALKBH8	466	Q96BT7
LHLACASGHVQVVTL	ANKRD20A4P	71	Q4UJ75
NSCHDFASHLQRLIL	ARHGEF38	406	Q9NXL2
LQHFELANSLCHSLK	FAM220BP	241	B1ANY3
TIHLHLCICLFVGST	ADGRE5	581	P48960
TCLRFLLLSAHSHFI	ARID2	311	Q68CP9
VQFSLLHSKFHLCSV	AP2A1	521	O95782
AFTDHVECLQLLLSH	ANKRD28	831	O15084
SSDCKHQLVSTVIFH	ABCA13	611	Q86UQ4
ITLASSICQAHFFHL	DNHD1	2901	Q96M86
QLSAACSHSHFVRLF	CDAN1	491	Q8IWY9
IQSCLTHFSLITHGF	TFAP2B	391	Q92481
SSLHQTCAENLIAIH	NBEAL1	501	Q6ZS30
LNHLCQASRTVIHSA	RFX4	326	Q33E94
LSHISACDGIFHLTR	OLA1	111	Q9NTK5
EHQRALIQLATCHFA	INTS10	491	Q9NVR2
GHSHQLFHVCVILAT	PAQR5	251	Q9NXK6
LHLACASGHVQVVTL	ANKRD20A2P	71	Q5SQ80
VTLDYLTALHVAAHC	ANK2	361	Q01484
HHLATVDCIFSLAKV	MSH3	826	P20585
THTLLLIQLLFCNHN	OR1S1	171	Q8NH92
AASTCALHLAVTFLH	OR10AC1	241	Q8NH08
HIYLSHLVTANLLVC	GPR82	51	Q96P67
ELCTHHGALRSIFSQ	GPN2	116	Q9H9Y4
LHHISLLFSTINSSA	MAS1	261	P04201
NHSISVHGLCLALSH	EYS	611	Q5T1H1
IHTHCNNLFTTLVIL	KIAA0825	726	Q8IV33
LAACTSDFVIHGIIH	METRN	181	Q9UJH8
HLESFSVALCHSTLQ	LRR1	211	Q96L50
DSFLSNILQDCRHHL	MMS19	346	Q96T76
RHLCCLQALSAVSTH	MMS19	551	Q96T76
LVHENNTHFLCTHLL	ALOXE3	401	Q9BYJ1
RTEALNHHNLLVCSV	HLA-DQB2	136	P05538
RSVHTLTSFCSALHI	GRIA4	101	P48058
SVLAAALLHAVCFSA	PCNX2	1006	A6NKB5
LSHAFCLHQDVLRLS	OR51L1	176	Q8NGJ5
LSHSFCLHQEVIQLA	OR51M1	186	Q9H341
IHAADVTQTVHCFLL	PDE1B	226	Q01064
EHHLSEVALQTALSC	FRYL	1806	O94915
QSSRSHAIFTIHLCQ	KIF21B	221	O75037
HTHTLSLTDINELVC	LAMB2	1396	P55268
NEFAHCTVITIAHRL	ABCC2	1481	Q92887
CHVHLVSIFLSALNS	MRGPRX3	251	Q96LB0
HHIANLCDSLNHFLT	FOXJ2	461	Q9P0K8
LCDSLNHFLTQTGHV	FOXJ2	466	Q9P0K8
SHFCTALVSLTHLFA	GPR101	101	Q96P66
DDVSLHHLINALCSL	MON2	761	Q7Z3U7
TLSSQATHEAVHLLC	NLK	391	Q9UBE8
THKAISFLGCISQLH	OR12D2	86	P58182
KAFHTCASHLTVVAL	OR2F1	236	Q13607
KAFHTCASHLTVVAL	OR2F2	236	O95006
NSTLIVLICNDSHLH	OR9G9	41	P0C7N8
SRCHVHDFILLNTDL	GREB1L	1686	Q9C091
RFIALCHENSSLHGI	HELZ	1066	P42694
HLVDAHTAEVNCLSF	RBBP7	266	Q16576
LHSFCLSLQLEVLHS	MED14	296	O60244
GSNVIHHFLCHVLSL	OR10H3	171	O60404
LLSTHHSITFVACAN	OR10H4	86	Q8NGA5
THTLLLIQLLFCDHN	OR1S2	171	Q8NGQ3
LVIFHLSFCSSHEIQ	OR10Z1	161	Q8NGY1
HQAFSTCSAHLLVVS	OR10A4	236	Q9H209
AHKAISFLGCISQLH	OR12D1	86	P0DN82
DISLHHECFNSTVLR	RIMS1	1081	Q86UR5
LQTLEHLCSNHSVIL	METTL21A	156	Q8WXB1
TCSSHLILILFHTGI	OR56B4	246	Q8NH76
GHQIFHAFLSICTLS	PAQR8	281	Q8TEZ7
HLTEFQCVSSALLVH	PLEKHG6	476	Q3KR16
SRTEALNHHNLLVCS	HLA-DQB1	136	P01920
LHLACASGHVQVVTL	ANKRD20A3P	71	Q5VUR7
AFSQLISRICHSHDE	ATR	2141	Q13535
LCVSDGSLLSVLAHH	PRMT7	406	Q9NVM4
HTIAAHCTQLTHLYL	FBXL7	291	Q9UJT9
SHCLHTAITTLVVAL	FITM2	181	Q8N6M3
TLTHSHCSLLVNRAL	FRMPD2	251	Q68DX3
IHHKVLSLNFSECHT	G3BP2	61	Q9UN86
SCELVVEHIQSFLHS	ARFGEF3	1536	Q5TH69
CSRTHSQLAQFVHEV	DDX12P	251	Q92771
LLHIARTHSFENVSC	DENND4C	1091	Q5VZ89
HALFTALHVTQCLSL	ACKR3	291	P25106
SAVLLDHCHFSQVIF	CALCOCO2	11	Q13137
VLSLCSHRVNHAFLF	COL27A1	101	Q8IZC6
IAHLLETHLIAEAFC	ALOX12B	396	O75342
NLHCSQQEHFVLSAL	ESCO2	46	Q56NI9
LSFTHHQIIELARDC	MAST4	411	O15021
NTSICVVNSHLAAHI	INPP5B	471	P32019
LHLLIALSCNSNFHS	FRY	1691	Q5TBA9
HLAAIATELAQAHIC	DNAAF5	471	Q86Y56
CVHDSTVHSRVFQIL	FAM135B	61	Q49AJ0
IGNHLFSTISVFCHL	DNAH2	896	Q9P225
FLRCHSGIHLSSDVT	SCUBE2	471	Q9NQ36
AGASCVNLLILSHHS	NLGN2	266	Q8NFZ4
CSSSIHLLEHSVELL	FOCAD	286	Q5VW36
HFHQLLCLLNSQIAS	TBRG4	126	Q969Z0
CLTSIAAHAFHGLTA	LINGO4	311	Q6UY18
FLLSLLACFQTSSHA	PKN3	621	Q6P5Z2
AVSSHHSIICQLLSD	POTEA	271	Q6S8J7
KNALVCSHDHLTLFL	PLEKHM2	126	Q8IWE5
CSHDHLTLFLTLVSG	PLEKHM2	131	Q8IWE5
NTHIIHTALIATGCF	OR1D4	191	P47884
NTHIIHTALIATGCF	OR1D5	191	P58170
CFSHLSGRLTLSAQH	SND1-IT1	31	Q9HBX3
DLHLSVSEVQSCRHF	VARS2	731	Q5ST30
QALVLLTHCHSLSSF	SESN2	196	P58004
SISLASCHQLHSKFL	UTP20	2531	O75691
QVHLVICSSFLSLAN	RNF207	291	Q6ZRF8
ALVAQACHAATAALH	PTRHD1	46	Q6GMV3
CLHAISVSLEDTHIQ	SSPOP	616	A2VEC9
AILHSSVFQECHRLV	SSPOP	761	A2VEC9
LHTTSHLHSDFVECQ	TRPC4AP	81	Q8TEL6
HQANALHCVTTVASA	TOP6BL	46	Q8N6T0
ALSHLAEFLQSHASL	SYNE1	1866	Q8NF91
SVQEHCTFSHQLLEL	SYNE3	646	Q6ZMZ3
VHSHNDFLLAILTRC	TADA1	56	Q96BN2
HIHLQQLTCFSITCS	KRT34	26	O76011
LSAHSVLVNSHLVCK	EPHB6	796	O15197
FNHTLSECHVELSQS	GPR182	36	O15218
ISSTHAHHLRCLNDF	SH3GLB1	216	Q9Y371
FVHSIAALLCRSHQL	TANC1	521	Q9C0D5
QDLRAVLHCIHSFIA	SNTG2	501	Q9NY99
VLHCIHSFIAAKVAS	SNTG2	506	Q9NY99
LHLQLQSKHDAATCF	NAPA	71	P54920
ILLHLVGEVSCSHSF	SLF2	1091	Q8IX21
CHVHLVSIFLSALNS	MRGPRX1	251	Q96LB2
SAELLHLSLNTDVCH	SWT1	531	Q5T5J6
NTTFCIVNSHLAAHV	OCRL	366	Q01968
FTHSHVVSLVSAAAC	STK36	791	Q9NRP7
LQASVELHQFCHLSN	SPTBN5	1516	Q9NRC6
ASLFHILQTDHCAQT	STC1	191	P52823
AVHLESDAFLVCLNH	BRCC3	11	P46736
THLSFKLNVDSHCAL	AKAP6	821	Q13023
AHVLELSAELVCLSH	ACSL3	331	O95573
IVSSLHQAAAAACLS	APC	2111	P25054
LSVCFIASCLVTHHN	CLEC4D	31	Q8WXI8
FSALCLQISRHLHLN	CHPT1	366	Q8WUD6
SNLSEIHVAFHLCVD	C12orf4	421	Q9NQ89
IFCLIVLSLSTFHIH	C11orf87	71	Q6NUJ2
TELLILAHHCFTLTC	SPG11	2116	Q96JI7
AEACAVHALFLILHS	PITPNM1	421	O00562
SAQLCAALLHHFHVE	RAPGEF3	431	O95398
AFSQLSCLIVHQRIH	ZNF35	426	P13682
LAASHLHLNSVVKAC	ZBTB5	101	O15062
AFLLSSCLVQHQRIH	ZSCAN31	331	Q96LW9
FFCQSALTAHQRIHT	ZNF334	386	Q9HCZ1
FLCTKSALIAHQITH	ZNF334	441	Q9HCZ1
TFQCKHTSALSSHVL	REV3L	576	O60673
QLHLHESCVLSLKFA	TLE4	696	Q04727
ECFFLTLHAHHLSIL	UBE4B	756	O95155
ATVSFLSAHCASHLA	TMEM214	571	Q6NUQ4
SFNCSSDLIVHQRIH	ZNF322	301	Q6U7Q0
AFNHCSLLTIHERTH	ZNF682	321	O95780
AFRTCSDLTAHLLIH	ZNF534	431	Q76KX8
QCSLFQTIIHATHSV	TECPR2	1036	O15040
VLASLAVSCAQHSRH	nan	151	Q6ZWC4
LLIHAALNCTSSVHK	TTC38	421	Q5R3I4
ALTQAECVHFATHIS	TTC28	1536	Q96AY4
FLTKSHLICHQTVHT	ZNF547	361	Q8IVP9
SSVCHTALFLFAHEL	VN1R5	196	Q7Z5H4
IVNLIGICAFSHAHS	SLC30A5	531	Q8TAD4
TFSQSCSLLEHHRIH	ZKSCAN3	406	Q9BRR0
TSHLVSHTVFRCQLC	ZNF462	1651	Q96JM2
AALCSLVHSQHVFLA	F2	16	P00734
LVESHIQHSLNAICT	ZSWIM1	321	Q9BR11
QLHLHESCVLSLKFA	TLE2	666	Q04725
FSDCSALVQHQRIHT	ZNF79	286	Q15937
EHSSVQCFSHTVNLI	ZBED4	821	O75132
LCLVSLFLHSLVSAH	VN1R2	66	Q8NFZ6