Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cardiac muscle thin filament assembly	NRAP NEBL	1.59e-05	3	48	2	GO:0071691
GeneOntologyCellularComponent	postsynaptic density, intracellular component	TNIK GRIN2B NR3C1	1.94e-04	49	48	3	GO:0099092
GeneOntologyCellularComponent	postsynaptic specialization, intracellular component	TNIK GRIN2B NR3C1	2.89e-04	56	48	3	GO:0099091
HumanPheno	Bruising susceptibility	FGB NR3C1 RUNX1 AEBP1 ITGB3 NBEAL2 GGCX	8.63e-06	178	23	7	HP:0000978
HumanPheno	Impaired collagen-induced platelet aggregation	RUNX1 ITGB3 NBEAL2	4.33e-05	16	23	3	HP:0008320
HumanPheno	Impaired thrombin-induced platelet aggregation	ITGB3 NBEAL2	5.84e-05	3	23	2	HP:0011872
HumanPheno	Prolonged bleeding time	RUNX1 MAP2K2 ITGB3 NBEAL2	6.34e-05	50	23	4	HP:0003010
HumanPheno	Subcutaneous hemorrhage	FGB NR3C1 RUNX1 AEBP1 ITGB3 NBEAL2 GGCX	9.60e-05	258	23	7	HP:0001933
HumanPheno	Epistaxis	FGB RUNX1 ITGB3 NBEAL2 GGCX	9.69e-05	108	23	5	HP:0000421
HumanPheno	Ecchymosis	NR3C1 RUNX1 ITGB3 GGCX	1.14e-04	58	23	4	HP:0031364
HumanPheno	Menometrorrhagia	FGB ITGB3	1.93e-04	5	23	2	HP:0400008
HumanPheno	Abnormal alpha granules	RUNX1 NBEAL2	1.93e-04	5	23	2	HP:0012483
MousePheno	decreased erythroid progenitor cell number	NR3C1 RUNX1 KAT6A SON	1.77e-05	58	38	4	MP:0008973
MousePheno	decreased cardiac muscle relaxation	MICU2 NEBL	7.16e-05	5	38	2	MP:0020419
MousePheno	abnormal cardiac muscle relaxation	MICU2 NEBL ITGB3	7.90e-05	31	38	3	MP:0004084
MousePheno	decreased immature B cell number	RUNX1 MTOR KAT6A SON	1.14e-04	93	38	4	MP:0008215
MousePheno	abnormal erythroid progenitor cell morphology	NR3C1 RUNX1 KAT6A SON	1.51e-04	100	38	4	MP:0008801
Domain	NEBU	NRAP NEBL	3.71e-05	4	47	2	SM00227
Domain	Nebulin	NRAP NEBL	3.71e-05	4	47	2	PF00880
Domain	Nebulin	NRAP NEBL	3.71e-05	4	47	2	IPR013998
Domain	NEBULIN	NRAP NEBL	3.71e-05	4	47	2	PS51216
Domain	Nebulin_repeat	NRAP NEBL	3.71e-05	4	47	2	IPR000900
Domain	ARM-like	ARFGEF2 FRYL AGBL1 MTOR NBEAL2	5.68e-04	270	47	5	IPR011989
Domain	CARBOXYPEPT_ZN_1	AEBP1 AGBL1	1.14e-03	20	47	2	PS00132
Domain	Peptidase_M14	AEBP1 AGBL1	1.52e-03	23	47	2	PF00246
Domain	Peptidase_M14	AEBP1 AGBL1	1.52e-03	23	47	2	IPR000834
Domain	ARM-type_fold	ARFGEF2 FRYL AGBL1 MTOR NBEAL2	1.57e-03	339	47	5	IPR016024
Pathway	REACTOME_MAP2K_AND_MAPK_ACTIVATION	FGB MAP2K2 ITGB3	1.10e-04	39	34	3	MM15272
Pathway	REACTOME_MAP2K_AND_MAPK_ACTIVATION	FGB MAP2K2 ITGB3	1.19e-04	40	34	3	M27557
Pathway	REACTOME_SIGNALING_BY_MODERATE_KINASE_ACTIVITY_BRAF_MUTANTS	FGB MAP2K2 ITGB3	1.70e-04	45	34	3	M27623
Pathway	KEGG_ACUTE_MYELOID_LEUKEMIA	RUNX1 MAP2K2 MTOR	3.43e-04	57	34	3	M19888
Pathway	WP_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION	RUNX1 CIITA ITGB3	4.61e-04	63	34	3	M39366
Pathway	REACTOME_SIGNALING_BY_BRAF_AND_RAF1_FUSIONS	FGB MAP2K2 ITGB3	5.06e-04	65	34	3	M38994
Pathway	WP_ACUTE_MYELOID_LEUKEMIA	RUNX1 MAP2K2 MTOR	5.77e-04	68	34	3	M48322
Pathway	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	FGB ITGB3	5.81e-04	15	34	2	M12101
Pathway	REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	FGB ITGB3	5.81e-04	15	34	2	M1262
Pathway	REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	FGB ITGB3	5.81e-04	15	34	2	MM14959
Pathway	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	FGB ITGB3	5.81e-04	15	34	2	MM14961
Pubmed	The mTOR-RUNX1 pathway regulates DC-SIGN expression in renal tubular epithelial cells.	RUNX1 MTOR	1.87e-06	2	48	2	31540687
Pubmed	The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation.	FGB ITGB3	1.87e-06	2	48	2	20538554
Pubmed	Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis.	SGPP1 RUNX1	1.87e-06	2	48	2	27869314
Pubmed	RUNX1 promotes proliferation and migration in non-small cell lung cancer cell lines via the mTOR pathway.	RUNX1 MTOR	1.87e-06	2	48	2	37801076
Pubmed	SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemia.	RUNX1 SON	1.87e-06	2	48	2	33247227
Pubmed	Tissue and zonal-specific expression of an olfactory receptor transgene.	OR10H4 OR10H3	1.87e-06	2	48	2	9412503
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	ARFGEF2 ZNF326 ESPL1 MTOR CNOT2 SON	2.80e-06	288	48	6	23383273
Pubmed	Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress.	MAP2K2 MTOR	5.59e-06	3	48	2	15292274
Pubmed	Association of CBFA2 mutation with decreased platelet PKC-theta and impaired receptor-mediated activation of GPIIb-IIIa and pleckstrin phosphorylation: proteins regulated by CBFA2 play a role in GPIIb-IIIa activation.	RUNX1 ITGB3	1.12e-05	4	48	2	14525764
Pubmed	ERK activation causes epilepsy by stimulating NMDA receptor activity.	GRIN2B RUNX1	1.12e-05	4	48	2	17972914
Pubmed	Anti-angiogenic effects of thioridazine involving the FAK-mTOR pathway.	ITGB3 MTOR	1.12e-05	4	48	2	23022044
Pubmed	Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis.	RUNX1 SON	1.12e-05	4	48	2	18952841
Pubmed	Analysis of plasminogen activator inhibitor-1, integrin beta3, beta fibrinogen, and methylenetetrahydrofolate reductase polymorphisms in Iranian women with recurrent pregnancy loss.	FGB ITGB3	1.12e-05	4	48	2	21241403
Pubmed	The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through αvβ3 integrin interaction.	ITGB3 MTOR	1.12e-05	4	48	2	26621838
Pubmed	The DEL-1/β3 integrin axis promotes regulatory T cell responses during inflammation resolution.	RUNX1 ITGB3	1.12e-05	4	48	2	32817592
Pubmed	Synthetic lethal interaction between PI3K/Akt/mTOR and Ras/MEK/ERK pathway inhibition in rhabdomyosarcoma.	MAP2K2 MTOR	1.12e-05	4	48	2	23684925
Pubmed	Silencing of ETV6/RUNX1 abrogates PI3K/AKT/mTOR signaling and impairs reconstitution of leukemia in xenografts.	RUNX1 MTOR	1.12e-05	4	48	2	22094587
Pubmed	Analysis of inherited thrombophilic mutations and natural anticoagulant deficiency in patients with idiopathic portal hypertension.	FGB ITGB3	1.86e-05	5	48	2	18685811
Pubmed	Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo.	FGB ITGB3	1.86e-05	5	48	2	16824188
Pubmed	Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways.	FGB ITGB3	1.86e-05	5	48	2	10605720
Pubmed	MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2.	RUNX1 KAT6A	1.86e-05	5	48	2	11965546
Pubmed	[Associations of hemostasis factors genes with early development of ischemic heart disease and manifestation of myocardial infarction in young age].	FGB ITGB3	1.86e-05	5	48	2	16353042
Pubmed	Platelet polymorphisms: frequency distribution and association with coronary artery disease in an Indian population.	FGB ITGB3	1.86e-05	5	48	2	21034162
Pubmed	Absence of association between polymorphisms in the hemostatic factor pathway genes and carotid intimal medial thickness: the Framingham Heart Study.	FGB ITGB3	1.86e-05	5	48	2	14963283
Pubmed	Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors.	MAP2K2 MTOR	1.86e-05	5	48	2	24011934
Pubmed	Spectrum and prevalence of prothrombotic single nucleotide polymorphism profiles in the Greek Cypriot population.	FGB ITGB3	2.79e-05	6	48	2	12518110
Pubmed	Comparison of thrombophilic gene mutations among patients experiencing recurrent miscarriage and deep vein thrombosis.	FGB ITGB3	2.79e-05	6	48	2	18803625
Pubmed	Connection between genetically determined blood coagulation factors and haemorheology.	FGB ITGB3	2.79e-05	6	48	2	18503143
Pubmed	MOZ is essential for maintenance of hematopoietic stem cells.	RUNX1 KAT6A	2.79e-05	6	48	2	16702405
Pubmed	Mutations and polymorphisms in genes affecting haemostasis components in children with thromboembolic events.	FGB ITGB3	2.79e-05	6	48	2	17230042
Pubmed	Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.	ZNF326 GRIN2B	2.79e-05	6	48	2	20197096
Pubmed	Role of thrombophilic gene polymorphisms in branch retinal vein occlusion.	FGB ITGB3	2.79e-05	6	48	2	16157382
Pubmed	Prothrombotic polymorphisms, mutations, and their association with pediatric non-cardioembolic stroke in Asian-Indian patients.	FGB ITGB3	3.90e-05	7	48	2	18836720
Pubmed	Mutations and polymorphisms in genes affecting hemostasis proteins and homocysteine metabolism in children with arterial ischemic stroke.	FGB ITGB3	3.90e-05	7	48	2	16567932
Pubmed	Multiple thrombophilic gene mutations rather than specific gene mutations are risk factors for recurrent miscarriage.	FGB ITGB3	3.90e-05	7	48	2	16635210
Pubmed	Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein.	RUNX1 KAT6A	3.90e-05	7	48	2	11742995
Pubmed	Early pregnancy loss in celiac women: The role of genetic markers of thrombophilia.	FGB ITGB3	3.90e-05	7	48	2	19395327
Pubmed	Physical and functional link of the leukemia-associated factors AML1 and PML.	RUNX1 KAT6A	3.90e-05	7	48	2	15331439
Pubmed	Polymorphisms in prothrombotic genes and their impact on ischemic stroke in a Sardinian population.	FGB ITGB3	3.90e-05	7	48	2	15968394
Pubmed	Thrombophilic gene polymorphisms are risk factors for unexplained infertility.	FGB ITGB3	3.90e-05	7	48	2	18930220
Pubmed	Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release.	FGB ITGB3	5.19e-05	8	48	2	27221710
Pubmed	COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway.	ITGB3 MTOR	5.19e-05	8	48	2	25792870
Pubmed	Impact of genetic polymorphisms on platelet function and aspirin resistance.	FGB ITGB3	6.67e-05	9	48	2	19923980
Pubmed	Candidate genetic markers and the risk of restenosis after coronary angioplasty.	FGB ITGB3	6.67e-05	9	48	2	12899665
Pubmed	Understanding the cell fate and behavior of progenitors at the origin of the mouse cardiac mitral valve.	ITGB3 ACLY	6.67e-05	9	48	2	38198889
Pubmed	Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity.	GRIN2B NR3C1	6.67e-05	9	48	2	16554481
Pubmed	A prospective case-control study analyzes 12 thrombophilic gene mutations in Turkish couples with recurrent pregnancy loss.	FGB ITGB3	8.33e-05	10	48	2	19906129
Pubmed	Prevalence of prothrombotic polymorphisms in Greece.	FGB ITGB3	8.33e-05	10	48	2	19072566
Pubmed	Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway.	ITGB3 MTOR	8.33e-05	10	48	2	19889638
Pubmed	The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to IIb/IIIa antagonists.	FGB ITGB3	8.33e-05	10	48	2	12082590
Pubmed	Vascular at-risk genotypes and disease severity in Lebanese sickle cell disease patients.	FGB ITGB3	8.33e-05	10	48	2	20425806
Pubmed	A comprehensive analysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel disease: data from Turkey.	FGB ITGB3	8.33e-05	10	48	2	17111197
Pubmed	Characterization of single-nucleotide polymorphisms in coding regions of human genes.	FGB NR3C1 ITGB3	1.11e-04	67	48	3	10391209
Pubmed	Genetic influences on lipid metabolism trait variability within the Stanislas Cohort.	FGB ITGB3	1.22e-04	12	48	2	11714857
Pubmed	Potential thrombophilic mutations/polymorphisms in patients with no flow-limiting stenosis after myocardial infarction.	FGB ITGB3	1.22e-04	12	48	2	12514663
Pubmed	Genetic influences on blood pressure within the Stanislas Cohort.	FGB ITGB3	1.44e-04	13	48	2	15076187
Pubmed	Genetic cardiovascular risk factors and age-related macular degeneration.	FGB ITGB3	1.44e-04	13	48	2	19860767
Pubmed	p130Cas: a versatile scaffold in signaling networks.	FGB ITGB3	1.68e-04	14	48	2	16581250
Pubmed	Integrins and Src: dynamic duo of adhesion signaling.	FGB ITGB3	1.68e-04	14	48	2	16005629
Pubmed	Gene polymorphisms in association with emerging cardiovascular risk markers in adult women.	FGB ITGB3	1.68e-04	14	48	2	20078877
Pubmed	Molecular variation at functional genes and the history of human populations--data on candidate genes for cardiovascular risk in the Mediterranean.	FGB ITGB3	1.94e-04	15	48	2	14746139
Pubmed	Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2-/- Mice.	GRIN2B MTOR	2.21e-04	16	48	2	30466882
Pubmed	Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis.	OR10H4 OR10H3	2.21e-04	16	48	2	17521568
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	ZNF326 MAP2K2 MTOR ACLY GPS1 SON	2.37e-04	638	48	6	33239621
Pubmed	Lp(a) and risk of recurrent cardiac events in obese postinfarction patients.	FGB ITGB3	2.50e-04	17	48	2	18927546
Pubmed	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.	GRIN2B IGSF21	2.81e-04	18	48	2	28864826
Pubmed	Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.	RUNX1 ITGB3	2.81e-04	18	48	2	20887958
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	CTH STX18 ESPL1 MTOR ACLY SEC62 GPS1	2.92e-04	942	48	7	31073040
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	AEBP1 PLEKHA7 ITGB3 ZKSCAN5 SON	3.12e-04	430	48	5	35044719
Pubmed	Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.	CNOT2 UNC13A	3.85e-04	21	48	2	22959728
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	TNIK ZNF326 STX18 MTOR GPS1 SON	4.01e-04	704	48	6	29955894
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZNF326 NR3C1 ZKSCAN5 ZFAND4 CNOT2 EVX2	4.16e-04	709	48	6	22988430
Pubmed	Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen.	FGB ITGB3	4.23e-04	22	48	2	12871600
Pubmed	B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS.	MAP2K2 MTOR	4.23e-04	22	48	2	24733831
Pubmed	Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.	CTH MTOR	4.23e-04	22	48	2	26166573
Pubmed	Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.	MAP2K2 MTOR	5.05e-04	24	48	2	32043969
Pubmed	mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.	MTOR GPS1	5.48e-04	25	48	2	30340022
Pubmed	Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994.	FGB ITGB3	5.93e-04	26	48	2	21054877
Pubmed	Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.	ZNF326 RUNX1 ACLY GPS1	6.30e-04	283	48	4	28533407
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ARFGEF2 RUNX1 ESPL1 MAP2K2 ACLY SON	6.60e-04	774	48	6	15302935
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ARFGEF2 FRYL MAN2B1 ESPL1 MTOR NBEAL2 KAT6A	7.57e-04	1105	48	7	35748872
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	FRYL RUNX1 GPS1	7.63e-04	129	48	3	23022380
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	ARFGEF2 FRYL CTH NR3C1 MAN2B1 MTOR ACLY GPS1	7.81e-04	1455	48	8	22863883
Pubmed	Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling.	GRIN2B IGSF21	8.45e-04	31	48	2	21300867
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ZNF326 STX18 MICU2 NEBL PLEKHA7 CNOT2 GGCX SON	9.39e-04	1497	48	8	31527615
Pubmed	Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA.	RUNX1 EVX2	9.58e-04	33	48	2	30917309
Pubmed	Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.	TNIK FRYL NEBL MAP2K2 ACLY	1.01e-03	558	48	5	35063084
Pubmed	The genomic basis of cerebral palsy: a HuGE systematic literature review.	FGB ITGB3	1.02e-03	34	48	2	19238444
Pubmed	New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.	FGB ITGB3	1.08e-03	35	48	2	18513389
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	TNIK ARFGEF2 PLEKHA7 MTOR NBEAL2	1.10e-03	569	48	5	30639242
Pubmed	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	CTH NR3C1 STX18 ITGB3	1.13e-03	331	48	4	20634891
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	TNIK FRYL STX18	1.20e-03	151	48	3	17043677
Pubmed	Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.	FGB NR3C1 CIITA	1.23e-03	152	48	3	19578796
Pubmed	Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.	FGB ITGB3	1.27e-03	38	48	2	16263699
Cytoband	1p22.2	ZNF326 BARHL2	3.98e-04	28	48	2	1p22.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	OR10H4 MAN2B1 OR10H3 MAP2K2 UNC13A	1.44e-03	797	48	5	chr19p13
Coexpression	ANDERSON_BLOOD_CN54GP140_ADJUVANTED_WITH_GLA_AF_AGE_18_45YO_1DY_DN	ACLY KAT6A SON SH2D3C	1.65e-05	85	47	4	M41085
Coexpression	GSE27786_CD4_VS_CD8_TCELL_UP	ZNF326 FRYL GRIN2B ITGB3 SON	2.91e-05	200	47	5	M4819
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZBTB37 GRIN2B NRAP ZKSCAN5	2.65e-05	160	48	4	f2cdee5a9e3b0eb125d6be7b5d239eb04333ae41
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSGA10 ARFGEF2 RUNX1 CIITA	3.14e-05	167	48	4	f5bffa77061baec0ba87bd688a047595f32534db
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC14A1 NKAIN3 AEBP1 PLEKHA7	5.18e-05	190	48	4	78cc6c28b31de041c24175a98f47da256ecc15a2
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC14A1 NKAIN3 AEBP1 PLEKHA7	5.18e-05	190	48	4	3a55cc5dc2549788bfe55f649686887b21a1fdd2
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC14A1 NKAIN3 AEBP1 PLEKHA7	5.18e-05	190	48	4	e67d9400467b438592690b23d681e6c2fb8f09fd
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC14A1 NKAIN3 AEBP1 PLEKHA7	5.18e-05	190	48	4	b56c55f608b30f7379941ac7d5f0f5200f305fca
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC14A1 NKAIN3 AEBP1 PLEKHA7	5.18e-05	190	48	4	1c3d601422efa60fad8565f9ccd9032b847e4a91
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC14A1 NKAIN3 AEBP1 PLEKHA7	5.40e-05	192	48	4	f7e4509003d71f805b9d4587098e90d2897b6739
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC14A1 NKAIN3 AEBP1 PLEKHA7	5.40e-05	192	48	4	43beaac1de99b9c1a6dab4a450b4e81286987b64
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC14A1 NKAIN3 AEBP1 PLEKHA7	5.40e-05	192	48	4	705ce805cb00a53793b57bcf466d0fbec590a83c
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC14A1 NKAIN3 AEBP1 PLEKHA7	5.51e-05	193	48	4	b03d908d4b8940927f72c76a1b0f237d13f39056
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC14A1 NKAIN3 AEBP1 PLEKHA7	5.51e-05	193	48	4	40edc07b6e7f19f6ee885fa5af0b63ef1b0f2468
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TNIK ZBTB37 FRYL SLC14A1	5.51e-05	193	48	4	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	Control_saline-Endothelial-Endothelial-Activated_Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	CTH NR3C1 KAT6A SH2D3C	6.33e-05	200	48	4	be55cef682ba87250dad97689332c8820b3a7420
Disease	Adenoid Cystic Carcinoma	ESPL1 MAP2K2 KAT6A SON	1.82e-05	100	46	4	C0010606
Disease	response to selective serotonin reuptake inhibitor	ARFGEF2 GRIN2B AGBL1	2.88e-04	82	46	3	EFO_0005658
Disease	acute myeloid leukemia (is_implicated_in)	RUNX1 ITGB3 KAT6A	3.09e-04	84	46	3	DOID:9119 (is_implicated_in)
Disease	myocardial infarction (is_implicated_in)	FGB CIITA ITGB3	5.01e-04	99	46	3	DOID:5844 (is_implicated_in)
Disease	Barrett's esophagus	GRIN2B AGBL1	8.76e-04	28	46	2	EFO_0000280
Disease	Thrombocytopenia	RUNX1 ITGB3	9.40e-04	29	46	2	C0040034
Disease	Epileptic encephalopathy	GRIN2B MTOR	1.01e-03	30	46	2	C0543888
Disease	hypertension (implicated_via_orthology)	NR3C1 PLEKHA7 MTOR	1.06e-03	128	46	3	DOID:10763 (implicated_via_orthology)
Disease	androsterone sulfate measurement	MAP2K2 ZKSCAN5	1.22e-03	33	46	2	EFO_0021117
Disease	Bladder Neoplasm	ESPL1 IGSF21 MTOR	1.37e-03	140	46	3	C0005695
Disease	Malignant neoplasm of urinary bladder	ESPL1 IGSF21 MTOR	1.39e-03	141	46	3	C0005684

Protein segments in the cluster

Peptide	Gene	Start	Entry
AMRYGVESIYQAMTH	UNC13A	866	Q9UPW8
VMYTNGYEEMTFHGN	AEBP1	486	Q8IUX7
AYVMRYFESSGMTEH	CIITA	576	P33076
ADPSFYTYMMTHAAA	EVX2	256	Q03828
ETEDQGMYKYMSSQH	ARFGEF2	1596	Q9Y6D5
SMYSATKYMNGHSDV	CTH	206	P32929
EMGVSRSYTMESSYC	AGBL1	976	Q96MI9
DSMANSFVGTRSYMA	MAP2K2	221	P36507
PSAHGMMDDYTYVSV	NKAIN3	121	Q8N8D7
SYMHCNERMYRSGDA	NRAP	1471	Q86VF7
TMTIHNGMFFSTYDR	FGB	396	P02675
YVSADMHRMAAAFNT	GPS1	381	Q13098
HMMSLYSTHTYSRDC	FRYL	2146	O94915
TSGGQMYHYDMNTAS	NR3C1	326	P04150
GLHSMYSDALMATTY	OR10H3	266	O60404
GLHSMYSDALMATTY	OR10H4	266	Q8NGA5
MMYTGPSHHSYMNAA	KAT6A	1976	Q92794
DHMGMTASYTSNLAY	ESPL1	451	Q14674
DAMFSTNYSHMENYR	IGSF21	76	Q96ID5
FSSHYGSENSMSYTM	FBXL4	61	Q9UKA2
AAAAAAMYSSMYRTP	BARHL2	331	Q9NY43
YYRTNHTVMTMGSDF	MAN2B1	306	O00754
VGSDNHYSASTTMDY	ITGB3	301	P05106
TLTDDHSLYGGYMMS	KLF18	906	A0A0U1RQI7
TAMAGESYSRAYGAM	MTOR	1576	P42345
MSAMGSATRYHTYLP	RUNX1	341	Q01196
AHQMSLEGFTRYMDS	PLCZ1	126	Q86YW0
TMSQFEMDTYAKSHD	NBEAL2	1721	Q6ZNJ1
MQFSSLEHEGEYYMT	MICU2	91	Q8IYU8
GMRTYYFSADTQEDM	PLEKHA7	256	Q6IQ23
VFYNSEYSMPSTHAM	SGPP1	196	Q9BX95
RSAYDSTMETMNYAQ	ACLY	576	P53396
NMYYSQSSMFPHRSE	CNOT2	41	Q9NZN8
STHSQEMDSGTEYGM	TNIK	951	Q9UKE5
TNGLYGYSWDMMVHS	GGCX	391	P38435
YFRDHMSLNEMSTVS	ZBTB37	56	Q5TC79
STNMMGHRVDYFIAS	SEC62	36	Q99442
NAYSHTMSEYGRMTD	STX18	76	Q9P2W9
NMALSMYLSATGHYN	SLC14A1	181	Q13336
LAVYGASYHSMSSMA	TMEM208	61	Q9BTX3
ASYHSMSSMARAAFS	TMEM208	66	Q9BTX3
QNYSSNAYHMSSTMK	TSGA10	651	Q9BZW7
AYARSSDMYSHMGTM	SH2D3C	66	Q8N5H7
EHRMSGGSMYNSDTD	ZFAND4	186	Q86XD8
YSAADRSMMSSYSAA	SON	1096	P18583
SYSAADRSMMSSYTA	SON	1106	P18583
YGSITSMGYESRDNM	ZKSCAN5	251	Q9Y2L8
QRSMDSYLNQSYGMD	ZNF326	46	Q5BKZ1
YGYMHQTSVSSMRSM	NEBL	936	O76041
YAHMFEMSAGESTFA	GRIN2B	1336	Q13224